phenobarbital has been researched along with clotrimazole in 18 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (11.11) | 18.7374 |
| 1990's | 4 (22.22) | 18.2507 |
| 2000's | 5 (27.78) | 29.6817 |
| 2010's | 7 (38.89) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Beck, WT; Schuetz, EG; Schuetz, JD | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Sen, S; Sinha, N | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Franklin, MR; Ritter, JK | 2 |
| Hänninen, O; Kaliste-Korhonen, E; Kärenlampi, S; Laaksonen, M | 1 |
| Hirata, M; Nishibe, Y | 1 |
| Chabot, GG; Hanstein, WG; Mahnke, A; Roos, PH | 1 |
| Chirulli, V; Fiorio, R; Gervasi, PG; Longo, V; Marini, S; Mazzaccaro, A | 1 |
| Jemnitz, K; Török, G; Tóth, E; Vereczkey, L; Veres, Z | 1 |
| Kojima, K; Matsubara, T; Nagata, K; Yamazoe, Y | 1 |
| Imai, J; Yamazoe, Y; Yoshinari, K | 1 |
1 review(s) available for phenobarbital and clotrimazole
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
17 other study(ies) available for phenobarbital and clotrimazole
| Article | Year |
|---|---|
Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells.
Topics: Adenocarcinoma; ATP Binding Cassette Transporter, Subfamily B, Member 1; Base Sequence; Blotting, Northern; Cell Line; Clotrimazole; Colonic Neoplasms; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Dexamethasone; DNA Primers; Doxorubicin; Gene Expression Regulation, Neoplastic; Humans; Midazolam; Mixed Function Oxygenases; Molecular Sequence Data; Multigene Family; Phenobarbital; Phenytoin; Polymerase Chain Reaction; Rifampin; Tumor Cells, Cultured; Verapamil | 1996 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship | 2011 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Induction of hepatic oxidative and conjugative drug metabolism in the hamster by N-substituted imidazoles.
Topics: Animals; Body Weight; Clotrimazole; Cricetinae; Cytochrome P-450 Enzyme System; Female; Glucuronates; Imidazoles; Ketoconazole; Male; Mesocricetus; Miconazole; Microsomes, Liver; Organ Size; Oxidation-Reduction; Phenobarbital; Sex Factors | 1987 |
High magnitude hepatic cytochrome P-450 induction by an N-substituted imidazole antimycotic, clotrimazole.
Topics: Animals; Biotransformation; Clotrimazole; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Activation; Imidazoles; Male; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains | 1987 |
P450 enzyme CYP2B catalyzes the detoxification of diisopropyl fluorophosphate.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cell Line; Clotrimazole; Cricetinae; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Inactivation, Metabolic; Isoflurophate; Isoquinolines; Male; Metyrapone; Microsomes, Liver; NADP; Oxidoreductases; Phenobarbital; Rats; Rats, Wistar; Steroid Hydroxylases | 1995 |
Induction of cytochrome P450 3A (CYP 3A) by E 5110, a non-steroidal anti-inflammatory agent (NSAID), and typical CYP 3A inducers in primary cultures of dog hepatocytes.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbamazepine; Cells, Cultured; Clofibrate; Clotrimazole; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Dogs; Drug Interactions; Enzyme Induction; Liver; Male; Mixed Function Oxygenases; Omeprazole; Phenobarbital; Phenytoin; Pyrrolidinones; Rifampin; Steroid Hydroxylases | 1995 |
In vivo induction of cytochrome P450 CYP3A expression in rat leukocytes using various inducers.
Topics: Animals; Blotting, Western; Clotrimazole; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Female; Leukocytes; Liver; Male; Microsomes; Mixed Function Oxygenases; Phenobarbital; Pregnenolone Carbonitrile; Rabbits; Rats; Rats, Sprague-Dawley | 1996 |
CAR and PXR expression and inducibility of CYP2B and CYP3A activities in rat and rabbit lungs.
Topics: Air Pollutants; Animals; Aryl Hydrocarbon Hydroxylases; Biomarkers; Calcium-Binding Proteins; Clotrimazole; Cytochrome P-450 CYP3A; Dexamethasone; Enzyme Induction; Eye Proteins; Isoenzymes; Lipoproteins; Lung; Male; Organ Specificity; Oxidoreductases, N-Demethylating; Pharmaceutical Preparations; Phenobarbital; Pregnane X Receptor; Rabbits; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Recoverin; Rifampin; Species Specificity | 2005 |
The spectrum of enzymes involved in activation of 2-aminoanthracene varies with the metabolic system applied.
Topics: Animals; Anthracenes; Benzoflavones; beta-Naphthoflavone; Clotrimazole; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Hepatocytes; Liver; Male; Mutagenesis; Mutagenicity Tests; Mutagens; Phenobarbital; Rats; Rats, Wistar; Salmonella typhimurium | 2005 |
Broad but distinct role of pregnane x receptor on the expression of individual cytochrome p450s in human hepatocytes.
Topics: Adenoviridae; Cells, Cultured; Clotrimazole; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Gene Expression Regulation, Enzymologic; Genetic Vectors; Hepatocytes; Humans; In Vitro Techniques; Isoenzymes; Lac Operon; Middle Aged; Phenobarbital; Pregnane X Receptor; Receptors, Steroid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering | 2007 |
Novel cell-based reporter assay system using epitope-tagged protein for the identification of agonistic ligands of constitutive androstane receptor (CAR).
Topics: Androstanols; Animals; Aryl Hydrocarbon Hydroxylases; Biological Assay; Clotrimazole; Constitutive Androstane Receptor; Cytochrome P-450 CYP2B6; Epitopes; Hep G2 Cells; Humans; Ligands; Liver; Mice; Phenobarbital; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Species Specificity | 2013 |