phenobarbital and cimetidine

phenobarbital has been researched along with cimetidine in 70 studies

Research

Studies (70)

Timeframe	Studies, this research(%)	All Research%
pre-1990	38 (54.29)	18.7374
1990's	11 (15.71)	18.2507
2000's	12 (17.14)	29.6817
2010's	9 (12.86)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET	1
Topliss, JG; Yoshida, F	1
Andricopulo, AD; Moda, TL; Montanari, CA	1
Lombardo, F; Obach, RS; Waters, NJ	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Glen, RC; Lowe, R; Mitchell, JB	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Kajfez, F; Rendić, S; Ruf, HH; Sunjić, V; Toso, R	1
Chen, SM; Hou, SJ; Lin, SY; Perng, RI; Young, TK	1
Hsieh, CY; Huang, JD	1
Hermans, JJ; Thijssen, HH	1
Fentem, JH; Fry, JR	1
Howells, RE; Ndifor, AM; Ward, SA	1
Kari, PH; Lu, AY; Vyas, KP; Wang, RW	1
Amouzadeh, HR; Nossaman, BC; Sangiah, S	1
Buscher, G; Dierdorf, HD; Greb, WH; Köster, FE; Mellows, G; Wolf, D	1
Desager, JP; Harvengt, C; Horsmans, Y; Leclercq, V; Van Nieuwenhuyze, Y	1
Babany, G; Babany, I; Kates, RE; Morris, RE; Shepherd, S	1
Evans, PC; Hardy, JR; Paxton, JW	1
Breimer, DD; Brugman, M; Schellens, JH; van der Wart, JH	1
Bellward, GD; Chang, T; Levine, M	1
Haasio, K; Männistö, PT; Schultz, E	1
Imai, Y; Inada, M; Kawata, S; Minami, Y; Noda, S; Tamura, S; Tarui, S	1
Argenbright, LS; Lu, AY; Miwa, GT; Wang, RW	1
Karvonen, I; Saarni, HU; Sotaniemi, EA; Stenbäck, F; Stengård, JH	1
Baciewicz, AM	1
Debreczeni, LA; Herjavecz, I; Szeitz, A	1
Eksymä, S; Gachalyi, B; Hämäläinen, A; Lahtela, JT; Sotaniemi, EA	1
Haataja, H; Männistö, PT; Saijonmaa, O	1
Døssing, M; Jørgensen, BG; Loft, S; Petersen, KT; Poulsen, HE; Sonne, J	1
Døssing, M; Loft, S; Pilsgaard, H; Poulsen, HE; Rasmussen, B; Sonne, J	1
Gachályi, B; Káldor, A; Vas, A	1
Duddy, SK; Hsia, MT	1
Benner, KE; Bennett, WM; Houghton, DC; Sasaki, AW; Schwass, DE	1
Foote, SE; Paxton, JW; Singh, RM	1
Amezcua, JL; Girón, E; Martinez-Tabche, L; Mourelle, M	1
Dixon, PA; Ogundahunsi, A; Okereke, NO	1
Boisset, M; Boudene, C; Cluet, JL	1
Bast, A; Kroes, BH; Savenije-Chapel, EM	1
Darvey, DL; Sorkin, EM	1
Williams, KM	1
Buchheit, WA; Rosenwasser, RH; Truex, RC	1
Goodman, AI; Ibraham, NG; Levere, RD; Lutton, JD; Solangi, KB; Svogun, JA	1
Døssing, M; Pilsgaard, H; Poulsen, HE; Rasmussen, B	1
Back, DJ; Sutcliffe, F; Tjia, JF	1
Alberts, DS; Dorr, RT	1
Glade, G; Pereira, GR; Saccar, CL	1
Gugler, R; Somogyi, A; Thielscher, S	1
Veng-Pedersen, P	1
Drew, R; Grygiel, JJ; Rowell, J	1
Combes, RD; Faux, SP	1
Amabeoku, GJ; Chikuni, O	1
Bellward, GD; Levine, M	1
Aijima, K; Inoue, C; Kaburagi, T; Nakamura, Y; Okuyama, M; Shigematsu, A	1
Andreeva, EM; Baimak, TY; Galyamova, MR; Kaledin, VI; Nikolin, VP; Popova, NA	1
BANKER, GS; WOLFSON, BB	1
Gonzalez Ortíz, R; Martínez-Tabche, L; Terrón, SO	1
Cho, HY; Lee, YB; Park, EJ	1
Barczyński, B; Czuczwar, SJ; Świąder, K; Świąder, MJ; Tomaszewski, M	1

Reviews

3 review(s) available for phenobarbital and cimetidine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Carbamazepine drug interactions. Therapeutic drug monitoring, 1986, Volume: 8, Issue:3 Topics: Carbamazepine; Cimetidine; Dextropropoxyphene; Drug Interactions; Erythromycin; Humans; Isoniazid; Lithium; Phenobarbital; Phenytoin; Primidone; Protein Binding; Troleandomycin; Valproic Acid; Warfarin	1986
Review of cimetidine drug interactions. Drug intelligence & clinical pharmacy, 1983, Volume: 17, Issue:2 Topics: Adrenergic beta-Antagonists; Animals; Anti-Anxiety Agents; Anti-Bacterial Agents; Benzodiazepines; Cimetidine; Diet; Drug Interactions; Glucose; Guanidines; Histamine H1 Antagonists; Humans; Imidazoles; Insulin; Ketoconazole; Metoclopramide; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Phenytoin; Piperazines; Propantheline	1983

Trials

2 trial(s) available for phenobarbital and cimetidine

Article	Year
The effect of liver enzyme inhibition by cimetidine and enzyme induction by phenobarbitone on the pharmacokinetics of paroxetine. Acta psychiatrica Scandinavica. Supplementum, 1989, Volume: 350 Topics: Adult; Antidepressive Agents; Biological Availability; Cimetidine; Clinical Trials as Topic; Enzyme Induction; Enzymes; Half-Life; Humans; Male; Microsomes, Liver; Paroxetine; Phenobarbital; Piperidines; Serotonin Antagonists	1989
The effect of liver microsomal enzyme inducing and inhibiting drugs on insulin mediated glucose metabolism in man. British journal of clinical pharmacology, 1986, Volume: 21, Issue:1 Topics: Adult; Antipyrine; Benzhydryl Compounds; Cimetidine; Enzyme Induction; Enzyme Inhibitors; Female; Glucose; Humans; Insulin; Kinetics; Male; Microsomes, Liver; Phenobarbital	1986

Article

Year

The effect of liver enzyme inhibition by cimetidine and enzyme induction by phenobarbitone on the pharmacokinetics of paroxetine.

Acta psychiatrica Scandinavica. Supplementum, 1989, Volume: 350

Topics: Adult; Antidepressive Agents; Biological Availability; Cimetidine; Clinical Trials as Topic; Enzyme Induction; Enzymes; Half-Life; Humans; Male; Microsomes, Liver; Paroxetine; Phenobarbital; Piperidines; Serotonin Antagonists

1989

The effect of liver microsomal enzyme inducing and inhibiting drugs on insulin mediated glucose metabolism in man.

British journal of clinical pharmacology, 1986, Volume: 21, Issue:1

Topics: Adult; Antipyrine; Benzhydryl Compounds; Cimetidine; Enzyme Induction; Enzyme Inhibitors; Female; Glucose; Humans; Insulin; Kinetics; Male; Microsomes, Liver; Phenobarbital

1986

Other Studies

65 other study(ies) available for phenobarbital and cimetidine

Article	Year
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs. Journal of medicinal chemistry, 1985, Volume: 28, Issue:3 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium	1985
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Hologram QSAR model for the prediction of human oral bioavailability. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Predicting phospholipidosis using machine learning. Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5 Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Interaction of cimetidine with liver microsomes. Xenobiotica; the fate of foreign compounds in biological systems, 1979, Volume: 9, Issue:9 Topics: Animals; Binding, Competitive; Cimetidine; Coumarins; Cytochrome P-450 Enzyme System; Guanidines; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Phenobarbital; Rats	1979
Effect of traditional Chinese herbal medicines on the pharmacokinetics of western drugs in Sprague-Dawley rats of different ages (II): Aminophylline-huan shao tan and aminophylline-pu chung yi chi tang. Mechanisms of ageing and development, 1992, Volume: 66, Issue:1 Topics: Aging; Aminophylline; Animals; Biological Availability; Cimetidine; Cytochrome P-450 Enzyme System; Drug Interactions; Drugs, Chinese Herbal; Phenobarbital; Rats; Rats, Sprague-Dawley; Theophylline	1992
Two-dimensional high-performance liquid chromatographic method to assay p-hydroxyphenylphenylhydantoin enantiomers in biological fluids and stereoselectivity of enzyme induction in phenytoin metabolism. Journal of chromatography, 1992, Mar-13, Volume: 575, Issue:1 Topics: Acetone; Animals; Aroclors; Chlorodiphenyl (54% Chlorine); Chromatography, High Pressure Liquid; Cimetidine; Dexamethasone; Diazepam; Enzyme Induction; Female; Ketoconazole; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Phenytoin; Rats; Safrole; Sex Characteristics; Stereoisomerism; Sulfaphenazole	1992
Comparison of the rat liver microsomal metabolism of the enantiomers of warfarin and 4'-nitrowarfarin (acenocoumarol). Xenobiotica; the fate of foreign compounds in biological systems, 1991, Volume: 21, Issue:3 Topics: Acenocoumarol; Animals; Chromatography, High Pressure Liquid; Cimetidine; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains; Spectrophotometry, Ultraviolet; Stereoisomerism; Warfarin	1991
Effect of cimetidine on the metabolism of coumarin by rat, gerbil and human liver microsomes. Biochemical pharmacology, 1991, Sep-12, Volume: 42, Issue:7 Topics: Animals; Cimetidine; Coumarins; Drug Interactions; Gerbillinae; Humans; Male; Microsomes, Liver; Models, Biological; Phenobarbital; Rats; Rats, Inbred Strains; Umbelliferones	1991
Cytochrome P-450 activity in malarial parasites and its possible relationship to chloroquine resistance. Molecular and biochemical parasitology, 1990, Volume: 41, Issue:2 Topics: 7-Alkoxycoumarin O-Dealkylase; Aminopyrine N-Demethylase; Animals; Chloroquine; Cimetidine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Resistance; Enzyme Induction; Kinetics; Phenobarbital; Plasmodium berghei; Plasmodium falciparum; Spectrum Analysis	1990
Biotransformation of lovastatin--III. Effect of cimetidine and famotidine on in vitro metabolism of lovastatin by rat and human liver microsomes. Biochemical pharmacology, 1990, Jan-01, Volume: 39, Issue:1 Topics: Animals; Biotransformation; Cimetidine; Cytochrome P-450 Enzyme System; Famotidine; Female; Humans; Lovastatin; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains	1990
Effects of chloramphenicol, cimetidine and phenobarbital on and tolerance to xylazine-ketamine anesthesia in dogs. Veterinary and human toxicology, 1990, Volume: 32, Issue:3 Topics: Anesthesia; Animals; Behavior, Animal; Chloramphenicol; Cimetidine; Consciousness; Dogs; Dose-Response Relationship, Drug; Drug Combinations; Drug Tolerance; Ketamine; Male; Phenobarbital; Reflex; Thiazines; Xylazine	1990
Influence of rifampicin, phenobarbital and cimetidine on mixed function monooxygenase in extensive and poor metabolizers of debrisoquine. International journal of clinical pharmacology, therapy, and toxicology, 1989, Volume: 27, Issue:12 Topics: Adult; Antipyrine; Biotransformation; Cimetidine; Debrisoquin; Half-Life; Humans; Hydroxylation; Isoquinolines; Male; Mixed Function Oxygenases; Phenobarbital; Phenotype; Rifampin	1989
In vivo evaluation of the effects of altered cyclosporine metabolism on its immunosuppressive potency. The Journal of pharmacology and experimental therapeutics, 1989, Volume: 248, Issue:3 Topics: Animals; Body Weight; Cimetidine; Cyclosporins; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Graft Survival; Heart Transplantation; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Phenobarbital	1989
The effect of cimetidine, phenobarbitone and buthionine sulphoximine on the disposition of N-5-dimethyl-9-[(2-methoxy-4-methyl-sulphonylamino)phenylamino]- 4-acridinecarboxamide (CI-921) in the rabbit. Cancer chemotherapy and pharmacology, 1989, Volume: 23, Issue:5 Topics: Amsacrine; Animals; Antimetabolites; Antineoplastic Agents; Buthionine Sulfoximine; Cimetidine; Dose-Response Relationship, Drug; Drug Interactions; Female; Glutathione; Male; Methionine Sulfoximine; Phenobarbital; Rabbits; Time Factors	1989
Influence of enzyme induction and inhibition on the oxidation of nifedipine, sparteine, mephenytoin and antipyrine in humans as assessed by a "cocktail" study design. The Journal of pharmacology and experimental therapeutics, 1989, Volume: 249, Issue:2 Topics: Adult; Antipyrine; Cimetidine; Enzyme Induction; Female; Humans; Hydantoins; Male; Mephenytoin; Metabolic Clearance Rate; Nifedipine; Oxidation-Reduction; Phenobarbital; Smoking; Sparteine	1989
Attenuation of low dose phenobarbital induction of hepatic microsomal aminopyrine N-demethylase activity in rats by cimetidine. Biochemical and biophysical research communications, 1989, Aug-15, Volume: 162, Issue:3 Topics: Aminopyrine N-Demethylase; Animals; Cimetidine; Dose-Response Relationship, Drug; Enzyme Induction; Male; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains	1989
Effects of phenobarbital and cimetidine on the blood glucose concentration and hepatic enzyme activities of congenitally obese mice. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1987, Volume: 8, Issue:5 Topics: Animals; Blood Glucose; Cimetidine; Diabetes Mellitus, Type 2; Female; Glucose-6-Phosphatase; Glucuronosyltransferase; Liver; Male; Mice; Mice, Obese; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Phenobarbital	1987
Interaction of famotidine with rat liver microsomes, a study showing less inhibition of drug metabolism than with cimetidine. Pharmacological research communications, 1986, Volume: 18, Issue:7 Topics: Aminopyrine N-Demethylase; Animals; Cimetidine; Cytochrome P-450 Enzyme System; Famotidine; Histamine H2 Antagonists; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Thiazoles	1986
In vitro studies on the interaction of famotidine with liver microsomal cytochrome P-450. Biochemical pharmacology, 1988, Aug-01, Volume: 37, Issue:15 Topics: Animals; Cimetidine; Cytochrome P-450 Enzyme System; Famotidine; Histamine H2 Antagonists; Humans; Male; Methylcholanthrene; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Rats; Rats, Inbred Strains; Spectrum Analysis; Thiadiazoles; Thiazoles	1988
Hepatic mixed function oxidase system and enzymatic glucose metabolism in rats. Diabetes research (Edinburgh, Scotland), 1987, Volume: 4, Issue:4 Topics: Animals; Carbon Tetrachloride; Cimetidine; Female; Glucokinase; Glucose; Glucose-6-Phosphatase; Hexokinase; Liver; Microsomes, Liver; Mixed Function Oxygenases; Muscles; Phenobarbital; Rats; Rats, Inbred Strains	1987
Effects of drugs on aminophylline elimination in rats. Arzneimittel-Forschung, 1988, Volume: 38, Issue:12 Topics: Aminophylline; Animals; Behavior, Animal; Carbamazepine; Cimetidine; Drug Combinations; Drug Interactions; Erythromycin; Female; Half-Life; Phenobarbital; Phenytoin; Rats; Rats, Inbred Strains; Rifampin; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination	1988
Effect of enzyme induction and inhibition on the fate of metronidazole and tinidazole in the rat. Pharmacology & toxicology, 1987, Volume: 60, Issue:1 Topics: Animals; Bile; Biotransformation; Chromatography, High Pressure Liquid; Cimetidine; Enzyme Induction; Enzyme Inhibitors; Male; Metronidazole; Nitroimidazoles; Phenobarbital; Rats; Rats, Inbred Strains; Tinidazole	1987
Inhibition and induction of metronidazole and antipyrine metabolism. European journal of clinical pharmacology, 1987, Volume: 32, Issue:1 Topics: Adult; Antipyrine; Cimetidine; Drug Interactions; Female; Humans; Hydroxylation; Kinetics; Male; Metronidazole; Phenobarbital	1987
Effect of concomitant administration of cimetidine and phenobarbital on antipyrine elimination and metabolite formation. International journal of clinical pharmacology, therapy, and toxicology, 1987, Volume: 25, Issue:4 Topics: Adult; Antipyrine; Biotransformation; Cimetidine; Female; Humans; Male; Phenobarbital	1987
Simultaneous microsomal monooxygenase enzyme system induction and inhibition, and the influence of the pharmacogenetic background: potential hazards in multi-drug therapy? International journal of clinical pharmacology, therapy, and toxicology, 1987, Volume: 25, Issue:7 Topics: Acetylation; Cimetidine; Drug Interactions; Humans; Phenobarbital	1987
Cytoprotective effects of modulators of oxidative xenobiotic metabolism in precocene II-induced hepatotoxicity. Fundamental and applied toxicology : official journal of the Society of Toxicology, 1987, Volume: 9, Issue:2 Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Benzopyrans; Cell Survival; Chemical and Drug Induced Liver Injury; Cimetidine; Dose-Response Relationship, Drug; Insecticides; Male; Methylcholanthrene; Oxidation-Reduction; Pharmaceutical Preparations; Phenobarbital; Plants; Proadifen; Rats; Rats, Inbred Strains	1987
Effect of phenobarbital and cimetidine on experimental cyclosporine nephrotoxicity: preliminary observations. Clinical nephrology, 1986, Volume: 25 Suppl 1 Topics: Animals; Cimetidine; Creatinine; Cyclosporins; Cytochrome P-450 Enzyme System; Drug Interactions; Inulin; Kidney Diseases; Kidney Tubules; Liver; Phenobarbital; Rats; Rats, Inbred F344; Urea	1986
The effect of buthionine sulphoximine, cimetidine and phenobarbitone on the disposition of amsacrine in the rabbit. Cancer chemotherapy and pharmacology, 1986, Volume: 18, Issue:3 Topics: Amsacrine; Animals; Buthionine Sulfoximine; Cimetidine; Erythrocytes; Glutathione; Kinetics; Liver; Methionine Sulfoximine; Mixed Function Oxygenases; Phenobarbital; Rabbits	1986
Cimetidine enhances and phenobarbital decreases parathion toxicity. Journal of applied toxicology : JAT, 1986, Volume: 6, Issue:6 Topics: Animals; Cimetidine; Drug Synergism; Liver; Male; Parathion; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains	1986
Influence of species and drug pretreatment on the metabolic oxidation of cimetidine and metiamide. Biochemical pharmacology, 1985, Jun-01, Volume: 34, Issue:11 Topics: Animals; Cats; Cimetidine; Ethanol; Male; Metiamide; Oxidation-Reduction; Phenobarbital; Rabbits; Rats; Species Specificity; Thiourea	1985
Effect of pretreatment with cimetidine or phenobarbital on lipoperoxidation in carbon tetrachloride- and trichloroethylene-dosed rats. Toxicology, 1986, Volume: 38, Issue:1 Topics: Alkanes; Animals; Carbon Tetrachloride; Cimetidine; Dose-Response Relationship, Drug; In Vitro Techniques; Lipid Peroxides; Liver; Male; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Thiobarbiturates; Trichloroethylene	1986
Inhibition of mono-oxygenase and oxidase activity of rat-hepatic cytochrome P-450 by H2-receptor blockers. Xenobiotica; the fate of foreign compounds in biological systems, 1984, Volume: 14, Issue:5 Topics: Animals; Cimetidine; Cytochrome P-450 Enzyme Inhibitors; Imidazoles; Male; Methylcholanthrene; Microsomes, Liver; Oxidoreductases; Phenobarbital; Ranitidine; Rats; Rats, Inbred Strains; Safrole	1984
Kinetics of misonidazole enantiomers. Clinical pharmacology and therapeutics, 1984, Volume: 36, Issue:6 Topics: Administration, Oral; Adult; Cimetidine; Drug Interactions; Female; Half-Life; Humans; Kinetics; Male; Misonidazole; Nitroimidazoles; Phenobarbital; Phenytoin; Stereoisomerism	1984
Management of subarachnoid hemorrhage. Pennsylvania medicine, 1984, Volume: 87, Issue:12 Topics: Adolescent; Adult; Aminocaproic Acid; Antihypertensive Agents; Child; Cimetidine; Dexamethasone; Humans; Intracranial Pressure; Ischemic Attack, Transient; Phenobarbital; Phenytoin; Subarachnoid Hemorrhage	1984
Pharmacologic toxicity of cimetidine on hepatic and renal drug metabolism. Research communications in chemical pathology and pharmacology, 1984, Volume: 45, Issue:1 Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Cimetidine; Cytochrome P-450 Enzyme System; Heme Oxygenase (Decyclizing); Kidney; Liver; Male; Pharmaceutical Preparations; Phenobarbital; Rats; Rats, Inbred Strains	1984
Time course of phenobarbital and cimetidine mediated changes in hepatic drug metabolism. European journal of clinical pharmacology, 1983, Volume: 25, Issue:2 Topics: Adult; Aminopyrine; Antipyrine; Biotransformation; Breath Tests; Cimetidine; Female; Half-Life; Humans; Liver; Male; Phenobarbital	1983
Tolbutamide as a model drug for the study of enzyme induction and enzyme inhibition in the rat. British journal of pharmacology, 1984, Volume: 81, Issue:3 Topics: Animals; Chloroquine; Cimetidine; Drug Interactions; Enzyme Induction; Enzyme Inhibitors; Kinetics; Male; Phenobarbital; Primaquine; Rats; Rats, Inbred Strains; Substrate Specificity; Tolbutamide	1984
Cimetidine enhancement of cyclophosphamide antitumour activity. British journal of cancer, 1982, Volume: 45, Issue:1 Topics: Animals; Cimetidine; Cyclophosphamide; Drug Synergism; Drug Therapy, Combination; Guanidines; Leukemia P388; Leukemia, Experimental; Male; Mice; Mice, Inbred DBA; Phenobarbital; Sleep	1982
Cimetidine in pregnancy: apparent transient liver impairment in the newborn. American journal of diseases of children (1960), 1980, Volume: 134, Issue:1 Topics: Adolescent; Adult; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Cimetidine; Female; Guanidines; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Infant, Small for Gestational Age; Male; Peptic Ulcer; Phenobarbital; Pregnancy; Pregnancy Complications; Respiratory Distress Syndrome, Newborn	1980
Influence of phenobarbital treatment on cimetidine kinetics. European journal of clinical pharmacology, 1981, Volume: 19, Issue:5 Topics: Adult; Biological Availability; Cimetidine; Drug Interactions; Female; Guanidines; Humans; Intestinal Absorption; Kinetics; Male; Metabolic Clearance Rate; Phenobarbital	1981
An algorithm and computer program for deconvolution in linear pharmacokinetics. Journal of pharmacokinetics and biopharmaceutics, 1980, Volume: 8, Issue:5 Topics: Absorption; Cimetidine; Computers; Kinetics; Mathematics; Pharmaceutical Preparations; Phenobarbital	1980
Cimetidine: a specific inhibitor of hepatic aryl hydrocarbon hydroxylase (AHH) in the rat. Research communications in chemical pathology and pharmacology, 1981, Volume: 33, Issue:1 Topics: Aniline Hydroxylase; Animals; Aryl Hydrocarbon Hydroxylases; Cimetidine; Guanidines; Hexobarbital; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Rats; Sleep	1981
Interaction of cimetidine with cytochrome P450 and effect on mixed-function oxidase activities of liver microsomes. Human & experimental toxicology, 1993, Volume: 12, Issue:2 Topics: Animals; Cimetidine; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; In Vitro Techniques; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Oxidoreductases; Phenobarbital; Rats; Rats, Wistar	1993
Cimetidine-induced seizures in mice. Antagonism by some GABAergic agents. Biochemical pharmacology, 1993, Dec-14, Volume: 46, Issue:12 Topics: Aminobutyrates; Aminooxyacetic Acid; Animals; Baclofen; Bicuculline; Cimetidine; Diazepam; Female; Mice; Muscimol; Phenobarbital; Phenytoin; Picrotoxin; Receptors, GABA; Seizures; Strychnine	1993
Effect of cimetidine on hepatic cytochrome P450: evidence for formation of a metabolite-intermediate complex. Drug metabolism and disposition: the biological fate of chemicals, 1995, Volume: 23, Issue:12 Topics: Animals; Cimetidine; Cytochrome P-450 Enzyme System; Histamine H2 Antagonists; Liver; Male; NADP; Phenobarbital; Rats; Rats, Wistar; Spectrometry, Fluorescence	1995
In vitro method for assessing hepatic drug metabolism. Biological & pharmaceutical bulletin, 1997, Volume: 20, Issue:1 Topics: Animals; Biopsy; Cimetidine; Cytochrome P-450 Enzyme System; Female; Liver; Male; Pharmaceutical Preparations; Phenobarbital; Rats; Rats, Wistar; Sex Factors	1997
Phenobarbital modifies antitumor effect of cyclophosphamide depending on the type of tumor cell death caused by it. Bulletin of experimental biology and medicine, 2003, Volume: 135, Issue:3 Topics: Animals; Anticonvulsants; Antineoplastic Agents, Alkylating; Apoptosis; Cell Line, Tumor; Cimetidine; Cyclophosphamide; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Humans; Mice; Mice, Inbred Strains; Neoplasm Transplantation; Neoplasms; Phenobarbital	2003
SOLUBILIZATION AND EVALUATION OF POLY-N-VINYL-5-METHYL-2-OXAZOLIDINONE BARBITURATE SYSTEMS. Journal of pharmaceutical sciences, 1965, Volume: 54 Topics: Barbiturates; Chemistry, Pharmaceutical; Cimetidine; Diphenhydramine; Drug Combinations; Ibuprofen; Ketanserin; Methylprednisolone; Oxazoles; Oxazolidinones; Phenobarbital; Povidone; Research; Solubility	1965
Effects of cimetidine and phenobarbital on methylparathion metabolism in Hyalella azteca. Bulletin of environmental contamination and toxicology, 2004, Volume: 72, Issue:6 Topics: Amphipoda; Animals; Cimetidine; Drug Interactions; Enzyme Inhibitors; Hypnotics and Sedatives; Insecticides; Lipid Peroxidation; Methyl Parathion; Phenobarbital; Water Pollutants, Chemical	2004
Effect of Cimetidine and Phenobarbital on metabolite kinetics of Omeprazole in rats. Archives of pharmacal research, 2005, Volume: 28, Issue:10 Topics: Algorithms; Animals; Area Under Curve; Chromatography, High Pressure Liquid; Cimetidine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Injections, Intraperitoneal; Injections, Intravenous; Male; Models, Biological; Omeprazole; Phenobarbital; Rats; Rats, Sprague-Dawley; Time Factors	2005
The effects of cimetidine chronic treatment on conventional antiepileptic drugs in mice. Pharmacological reports : PR, 2016, Volume: 68, Issue:2 Topics: Animals; Anticonvulsants; Brain; Carbamazepine; Cimetidine; Drug Interactions; Electroshock; Male; Memory, Long-Term; Mice; Phenobarbital; Phenytoin; Seizures; Valproic Acid	2016