phenobarbital has been researched along with chloroform in 86 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 68 (79.07) | 18.7374 |
| 1990's | 13 (15.12) | 18.2507 |
| 2000's | 4 (4.65) | 29.6817 |
| 2010's | 1 (1.16) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Caron, G; Ermondi, G | 1 |
| Abraham, MH; Acree, WE; Ibrahim, A | 1 |
| Abellán Guillén, A; Cordeiro, MN; Garrido Escudero, A; Morales Helguera, A; Pérez-Garrido, A | 1 |
| Glen, RC; Lowe, R; Mitchell, JB | 1 |
| Uehleke, H; Werner, T | 1 |
| Cascorbi, HF; Gesinski, RM; Komar, MK | 1 |
| Hook, JB; Kluwe, WM; McCormack, KM | 1 |
| Benthe, HF; Haberland, G; Schmoldt, A | 1 |
| Ford, JH; Gopinath, C | 1 |
| Frimmer, M; Homann, J; Rufeger, U | 1 |
| Barth, ML; Cornish, HH; Ling, B | 1 |
| Krishna, G; Pohl, LR | 1 |
| Batt, AM; Khodjet el Khil, R; Siest, G; Tridon, P; Weber, M | 1 |
| Fubini, B; Molinengo, L | 1 |
| Docks, EL; Krishna, G | 1 |
| Daniel, FB; Lin, EL; Olson, GR; Reddy, TV; Stober, JA | 1 |
| De Biasi, A; Keizer, J; Sbraccia, M; Testai, E; Vittozzi, L | 1 |
| Khan, S; O'Brien, PJ; Quan, Z | 1 |
| Goodman, JI; Vorce, RL | 1 |
| Cai, Z; Mehendale, HM | 1 |
| Borzelleca, JF; Clarke, EC; Condie, LW; Gennings, C; O'Hara, TM; Sheppard, MA | 1 |
| Cousins, MJ; Hall, PM; Ilsley, AH; Jenner, MA; Plummer, JL | 1 |
| Fox, TR; Maher, VM; McCormick, JJ; Schumann, AM; Watanabe, PG; Yano, BL | 1 |
| Tampo, Y; Yonaha, M | 1 |
| Lockard, VG; Mehendale, HM; Purushotham, KR | 2 |
| DeAngelo, AB; Guion, C; Pereira, MA; Savage, RE | 1 |
| Enosawa, S; Nakazawa, Y | 1 |
| Herren-Freund, SL; Knutsen, GL; Pereira, MA | 1 |
| el-Bakry, MS; Hebieshy, NA; Sheta, E | 1 |
| Clitherow, JW; Marlow, W; Smith, JC | 1 |
| Bailey, DN; Jatlow, PI | 1 |
| Kyogoku, Y; Yu, NT | 1 |
| Fink, BR; Kenny, GE; Simpson, WE | 1 |
| Brown, BR | 1 |
| Brown, BR; Sagalyn, AM; Sipes, IG | 1 |
| Ackerman, SJ; Brooks, SM; Sullivan, I; Thrasher, K; Werk, EE | 1 |
| Van Dyke, RA | 1 |
| Doyle, TD; Proctor, JB | 1 |
| Doctor, BP; Kullberg, MP; McGowan, FJ; Miller, WL | 1 |
| Brodin, A; Nilsson, MI | 1 |
| Korten, K; Van Dyke, RA | 1 |
| Ilett, KF; Krishna, G; Reid, WD; Sipes, IG | 1 |
| Barth, ML; Cornish, HH; Ling, BP | 1 |
| Burdino, E; Gabriel, L; Torrielli, MV; Ugazio, G | 1 |
| Niessing, J; Schaude, G; Siess, M; Vogell, W | 1 |
| Berry, DJ; Grove, J; Toseland, PA | 1 |
| Fiereck, EA; Tietz, NW | 1 |
| Kaser, MM; Milewski, KN; Rosenthal, WA | 1 |
| Buckmaster, HS; Shelley, LL; Van Meter, JC | 1 |
| McLean, AE | 1 |
| Dain, DW; Trainer, TD | 1 |
| Scholler, KL | 2 |
| Müller, E; Scholler, KL; von Plehwe, U | 1 |
| Clauberg, G | 1 |
| Heyndrickx, A; Okkerse, E; Van Hoof, F | 1 |
| Harasymiv, I; Hensley, WJ; Sampson, D | 1 |
| Sinnema, YA | 1 |
| Dickerson, G | 1 |
| Esplin, DW; Miyahara, JT; Zablocka, B | 1 |
| Bartels, E; Rosenberg, P | 1 |
| Blaustein, MP | 1 |
| Moore, L | 1 |
| Masuda, Y; Murano, T; Yano, I | 1 |
| Ahmadizadeh, M; Echt, R; Hook, JB; Kuo, CH | 1 |
| Branchflower, RV; George, JW; Pohl, LR; Schulick, RD | 1 |
| Bailie, MB; Hook, JB; Newton, JF; Smith, JH | 1 |
| Anders, MW; Harris, RN | 1 |
| Abdelsalam, EB; Adam, SE; Tartour, G | 1 |
| Bechtold, MM; Bruenner, U; Gee, DL; Tappel, AL | 1 |
| Kaminsky, LS; McMartin, DN; O'Connor, JA | 1 |
| Anders, MW; Stevens, JL | 2 |
| Carlson, GP | 1 |
| Buckiová, D; Musil, J; Nováková, V; Sollová, H; Táborský, O; Výborný, P | 1 |
| Ekström, T; Högberg, J | 1 |
| Anders, MW; Kubic, VL | 1 |
| Aoyama, T; Elovaara, E; Gelboin, HV; Klockars, M; Nakajima, T; Okino, T; Riihimäki, V; Vainio, H | 1 |
| Gemma, S; Sbraccia, M; Testai, E; Vittozzi, L | 1 |
| De Curtis, V; Fabrizi, L; Gemma, S; Gervasi, P; Testai, E; Vittozzi, L | 1 |
| Awe, SO; Makinde, JM; Olajide, OA | 1 |
| Finch, RA; Fort, DJ; Paul, RR; Rogers, RL; Stover, EL | 1 |
| HAMMANN, B; KURTZ, D; MANTZ, JM; METAIS, P; WARTER, J | 1 |
| BRECKENRIDGE, BM; GATFIELD, PD; MAYMAN, CI | 1 |
| SEKIYA, A; VAUGHANWILLIAMS, EM | 1 |
1 review(s) available for phenobarbital and chloroform
| Article | Year |
|---|---|
Biotransformation of volatile anaesthetics with special emphasis on the role of metabolism in the toxicity of anaesthetics.
Topics: Anesthesia, Inhalation; Anesthetics; Animals; Biotransformation; Chloroform; Cytochrome P-450 Enzyme System; Enzyme Induction; Ethyl Ethers; Halothane; Humans; Kidney; Liver; Liver Circulation; Methoxyflurane; Oxalates; Phenobarbital; Rats | 1973 |
1 trial(s) available for phenobarbital and chloroform
| Article | Year |
|---|---|
Adverse effects of phenobarbital on corticosteroid metabolism in patients with bronchial asthma.
Topics: Acetates; Adolescent; Adrenal Cortex Hormones; Adult; Asthma; Chloroform; Clinical Trials as Topic; Dexamethasone; Eosinophils; Female; Half-Life; Humans; Hydrocortisone; Hydroxycorticosteroids; Hydroxylation; Kinetics; Leukocyte Count; Male; Middle Aged; Phenobarbital; Placebos; Prednisone; Spirometry; Tritium | 1972 |
84 other study(ies) available for phenobarbital and chloroform
| Article | Year |
|---|---|
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water | 2005 |
Air to lung partition coefficients for volatile organic compounds and blood to lung partition coefficients for volatile organic compounds and drugs.
Topics: Air; Animals; Humans; Lung; Organic Chemicals; Probability; Rats; Tissue Distribution; Volatilization | 2008 |
Convenient QSAR model for predicting the complexation of structurally diverse compounds with beta-cyclodextrins.
Topics: beta-Cyclodextrins; Hydrophobic and Hydrophilic Interactions; Organic Chemicals; Quantitative Structure-Activity Relationship | 2009 |
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine | 2010 |
A comparative study on the irreversible binding of labeled halothane trichlorofluoromethane, chloroform, and carbon tetrachloride to hepatic protein and lipids in vitro and in vivo.
Topics: 1-Propanol; Aerobiosis; Age Factors; Anaerobiosis; Animals; Carbon Tetrachloride; Chloroform; Cobalt; Cytochrome P-450 Enzyme System; Endoplasmic Reticulum; Halothane; Humans; In Vitro Techniques; Lipid Metabolism; Liver; Methylcholanthrene; Mice; Microsomes, Liver; Mitochondria, Liver; NADP; Phenobarbital; Protein Binding; Rabbits; Rats; Species Specificity | 1975 |
Biotransformation, sex hormones, and toxicity of two volatile anesthetics in mice.
Topics: Animals; Biotransformation; Chloroform; Estradiol; Ethers; Female; Male; Mice; Mice, Inbred DBA; Phenobarbital; Testosterone | 1976 |
Selective modification of the renal and the hepatic toxicities of chloroform by induction of drug-metabolizing enzyme systems in kidney and liver.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Chloroform; Enzyme Induction; Inactivation, Metabolic; Kidney; Liver; Male; Methylcholanthrene; Mice; Oxidoreductases; Phenobarbital; Polychlorinated Biphenyls; Polychlorinated Dibenzodioxins | 1978 |
Impaired biliary excretion of digitoxin and its metabolites after treatment with polychlorinated biphenyls.
Topics: Animals; Bile; Biotransformation; Chloroform; Digitoxin; Drug Interactions; Male; Phenobarbital; Polychlorinated Biphenyls; Rats; Solubility; Water | 1979 |
The role of microsomal hydroxylases in the modification of chloroform hepatotoxicity in rats.
Topics: Animals; Carbon Disulfide; Chemical and Drug Induced Liver Injury; Chloroform; Chlorpromazine; DDT; Ditiocarb; Drug Interactions; Enzyme Induction; Female; Hexobarbital; Liver; Male; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Phenobarbital; Phenylbutazone; Proadifen; Rats; Sleep | 1975 |
[Inhibition by diethyldithiocarbamate (DEDTC) of acute hepatotoxic effects induced by polyhalogenated hydrocarbons (PHHC)].
Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Chloroform; Ditiocarb; Glutathione; Halothane; Hydrocarbons, Halogenated; Liver Diseases; Male; Microcirculation; Perfusion; Phenobarbital; Rats; Thiocarbamates; Trichloroethylene | 1976 |
Influence of aliphatic alcohols on the hepatic response to halogenated olefins.
Topics: Alcohols; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chloroform; Drug Synergism; Environmental Exposure; Ethanol; Hydrocarbons, Chlorinated; Liver; Phenobarbital; Rats; Trichloroethylene | 1977 |
Deuterium isotope effect in bioactivation and hepatotoxicity of chloroform.
Topics: Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Chloroform; Cysteine; Cytochrome P-450 Enzyme System; Deuterium; Male; Microsomes, Liver; Phenobarbital; Rats; Thiazoles | 1978 |
Method for diphenylhydantoin and phenobarbital assay by gas chromatography.
Topics: Buffers; Chloroform; Chromatography, Gas; Chromatography, Thin Layer; Colorimetry; Epilepsy; Humans; Methaqualone; Phenobarbital; Phenytoin | 1975 |
[Use of the principle of aspecificity in depressants of the central nervous system].
Topics: Alcohols; Animals; Barbital; Chloral Hydrate; Chloroform; Chlorpromazine; Depression, Chemical; Meprobamate; Phenobarbital; Procaine; Reflex; Spinal Nerves | 1975 |
The role of glutathione in chloroform-induced hepatotoxicity.
Topics: Acetone; Alkanes; Animals; Carbon Tetrachloride; Chloroform; Cysteamine; Cysteine; Dose-Response Relationship, Drug; Glutathione; Kidney; Lens, Crystalline; Liver; Male; Maleates; Methylcholanthrene; Phenobarbital; Propranolol; Rats | 1976 |
Chloroform inhibits the development of diethylnitrosamine-initiated, phenobarbital-promoted gamma-glutamyltranspeptidase and placental form glutathione S-transferase-positive foci in rat liver.
Topics: Analysis of Variance; Animals; Body Weight; Chloroform; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Dose-Response Relationship, Drug; Drinking; gamma-Glutamyltransferase; Glutathione Transferase; Humans; Liver; Male; Microsomes, Liver; Organ Size; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred F344 | 1992 |
The regioselective binding of CHCl3 reactive intermediates to microsomal phospholipids.
Topics: Animals; Biotransformation; Carbon Radioisotopes; Cell Hypoxia; Chloroform; Drug Synergism; Hydrolysis; Kinetics; Male; Methylation; Mice; Mice, Inbred Strains; Microsomes, Liver; Phenobarbital; Phospholipids; Rats; Rats, Sprague-Dawley | 1992 |
Role of cytochrome P-450IIE1 in N-nitroso-N-methylaniline induced hepatocyte cytotoxicity.
Topics: Alcohols; Animals; Aryl Hydrocarbon Hydroxylases; Cell Survival; Chloroform; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Liver; Male; Nitrosamines; Oxidoreductases, N-Demethylating; Phenobarbital; Pyrazoles; Rats; Rats, Inbred Strains; Steroid Hydroxylases | 1992 |
Hypomethylation of ras oncogenes in chemically induced and spontaneous B6C3F1 mouse liver tumors.
Topics: Animals; Carcinoma, Hepatocellular; Chloroform; DNA, Neoplasm; Gene Expression Regulation, Neoplastic; Genes, ras; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Methylation; Mice; Phenobarbital; Restriction Mapping; Rodent Diseases | 1991 |
Hepatotoxicity and lethality of halomethanes in Mongolian gerbils pretreated with chlordecone, phenobarbital or mirex.
Topics: Animals; Bromotrichloromethane; Carbon Tetrachloride; Chlordecone; Chloroform; DNA; Dose-Response Relationship, Drug; Gerbillinae; Lethal Dose 50; Liver; Male; Mirex; Phenobarbital; Species Specificity | 1991 |
A CCl4/CHCl3 interaction study in isolated hepatocytes: non-induced and phenobarbital-pretreated cells.
Topics: Animals; Carbon Tetrachloride; Cell Survival; Chloroform; Cytochrome P-450 Enzyme System; Drug Synergism; Enzyme Induction; In Vitro Techniques; L-Lactate Dehydrogenase; Liver; Phenobarbital; Potassium; Rats | 1991 |
Influence of enzyme induction and exposure profile on liver injury due to chlorinated hydrocarbon inhalation.
Topics: Administration, Inhalation; Animals; Biotransformation; Butylene Glycols; Carbon Tetrachloride; Chloroform; Dichloroethylenes; Enzyme Induction; Liver; Male; Phenobarbital; Rats; Rats, Inbred Strains; Time Factors | 1990 |
Mutational analysis of the H-ras oncogene in spontaneous C57BL/6 x C3H/He mouse liver tumors and tumors induced with genotoxic and nongenotoxic hepatocarcinogens.
Topics: Animals; Base Sequence; Benzidines; Chloroform; Clofibric Acid; Codon; DNA Mutational Analysis; DNA, Neoplasm; Fibric Acids; Gene Amplification; Genes, ras; Liver Neoplasms; Male; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Phenobarbital | 1990 |
Vitamin E and glutathione are required for preservation of microsomal glutathione S-transferase from oxidative stress in microsomes.
Topics: Animals; Antioxidants; Bromotrichloromethane; Chloroform; Glutathione; Glutathione Transferase; Kinetics; Lipid Peroxidation; Male; Microsomes, Liver; NADP; Phenobarbital; Rats; Rats, Inbred Strains; Sulfobromophthalein; Vitamin E | 1990 |
Amplification of chloroform hepatotoxicity and lethality by dietary chlordecone (kepone) in mice.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Body Weight; Chlordecone; Chloroform; Drug Synergism; Insecticides; Lethal Dose 50; Liver; Male; Mice; Mice, Inbred Strains; Mirex; Organ Size; Phenobarbital | 1988 |
The time course of liver injury and [3H]thymidine incorporation in chlordecone-potentiated CHCl3 hepatotoxicity.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Cell Nucleus; Chemical and Drug Induced Liver Injury; Chlordecone; Chloroform; DNA; Drug Synergism; Insecticides; Mice; Mirex; Phenobarbital; Time Factors | 1989 |
Studies on the mechanism of action of chloroform stimulation of rat hepatic ornithine decarboxylase (ODC).
Topics: Animals; Aroclors; Chlorodiphenyl (54% Chlorine); Chloroform; Cytosol; Female; Indomethacin; Injections, Intravenous; Liver; Male; Maleates; Ornithine Decarboxylase; Phenobarbital; Propranolol; Rats; Rats, Inbred F344; Reserpine; Stimulation, Chemical | 1987 |
Changes in cytochrome P450 molecular species in rat liver in chloroform intoxication.
Topics: Animals; Carbon Tetrachloride; Chloroform; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Liver; Male; Methylcholanthrene; Phenobarbital; Rats; Rats, Inbred Strains | 1986 |
Effect of subsequent treatment of chloroform or phenobarbital on the incidence of liver and lung tumors initiated by ethylnitrosourea in 15 day old mice.
Topics: Animals; Chloroform; Cocarcinogenesis; Dose-Response Relationship, Drug; Ethylnitrosourea; Female; Liver Neoplasms, Experimental; Lung Neoplasms; Male; Mice; Mice, Inbred Strains; Nitrosourea Compounds; Phenobarbital; Sex Factors | 1985 |
Hepatic histochemistry after chloroform effects of pretreatment with an enzyme inducer.
Topics: Acid Phosphatase; Animals; Chloroform; Dogs; Enzyme Induction; Esterases; Female; Histocytochemistry; Liver; Male; Phenobarbital; Succinate Dehydrogenase | 1985 |
An infrared study of the association between some 2,6-diamino-8,9-disubstituted purines and phenobarbitone in chloroform.
Topics: Chloroform; Phenobarbital; Purines; Spectrophotometry, Infrared; Structure-Activity Relationship | 1972 |
Methaqualone overdose: analytical methodology, and the significance of serum drug concentrations.
Topics: Alcohol Drinking; Alkanes; Chloroform; Chromatography, Gas; Chromatography, Thin Layer; Consciousness; Dextroamphetamine; Dose-Response Relationship, Drug; Drug Synergism; Histamine H1 Antagonists; Humans; Methadone; Methaqualone; Phenobarbital; Salicylamides; Scopolamine; Solubility; Spectrophotometry, Ultraviolet; Substance-Related Disorders | 1973 |
Specific H-bonding of glutarimides and hydantoins to derivatives of RNA bases in chloroform solution.
Topics: Bemegride; Chemical Phenomena; Chemistry; Chloroform; Cycloheximide; Ethosuximide; Glutethimide; Hydantoins; Pemoline; Phenobarbital; Phenytoin; Piperidines; Piperidones; Primidone; RNA; Spectrophotometry, Infrared; Thalidomide | 1973 |
Anesthetic potency compared with intensity of effect on oxygen consumption in monolayer cultures.
Topics: Amobarbital; Anesthetics; Anesthetics, Local; Animals; Barbiturates; Chloroform; Culture Techniques; Dibucaine; Ethers; Ethyl Ethers; Halothane; Lidocaine; Methohexital; Methoxyflurane; Mice; Oxygen Consumption; Phenobarbital; Prilocaine; Procaine; Secobarbital; Tetracaine; Thiamylal; Thiopental | 1968 |
Hepatic microsomal lipoperoxidation and inhalation anesthetics: a biochemical and morphologic study in the rat.
Topics: Animals; Chloroform; Ethers; Ethyl Ethers; Female; Halothane; In Vitro Techniques; Lipid Metabolism; Liver; Male; Microsomes, Liver; NADP; Phenobarbital; Rats | 1972 |
Mechanisms of acute hepatic toxicity: chloroform, halothane, and glutathione.
Topics: Acute Disease; Anesthesia, Inhalation; Aniline Compounds; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Chloroform; Chromatography, Gas; Cytochrome Reductases; Enzyme Induction; Glutathione; Halothane; Hexobarbital; Liver; Male; Maleates; Microsomes, Liver; Phenobarbital; Rats | 1974 |
Effects of solvent composition on the partition of barbiturates.
Topics: Amobarbital; Barbiturates; Chloroform; Chromatography; Ethers; Indicator Dilution Techniques; Mathematics; Pentobarbital; Phenobarbital; Secobarbital; Solvents; Temperature; Water | 1973 |
Studies in the single extraction of amphetamine and phenobarbital from urine using XAD-2 resin.
Topics: Acetates; Amphetamine; Butanols; Carbon Isotopes; Chlorine; Chloroform; Humans; Hydrocarbons, Halogenated; Hydrogen-Ion Concentration; Hydrolysis; Ion Exchange Resins; Male; Methods; Morphine; Phenobarbital; Solvents | 1973 |
Rates of transfer of organic protolytic solutes between an aqueous and an organic phase. II. Rates of mass transfer between water and different organic liquids.
Topics: Alprenolol; Benzene; Chloroform; Cyclohexanes; Ephedrine; Hydrogen-Ion Concentration; Methods; Nortriptyline; Pentobarbital; Phenobarbital; Phenylbutazone; Promazine; Solubility; Solvents; Water | 1973 |
Acute interaction of drugs. I. The effect of volatile anesthetics on the kinetics of aniline hydroxylase and aminopyrine demethylase in rat hepatic microsomes.
Topics: Aminopyrine N-Demethylase; Anesthetics; Aniline Compounds; Animals; Chloroform; Enzyme Induction; Ethyl Ethers; Halothane; In Vitro Techniques; Kinetics; Male; Methoxyflurane; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Phenobarbital; Rats | 1973 |
Chloroform toxicity in mice: correlation of renal and hepatic necrosis with covalent binding of metabolites to tissue macromolecules.
Topics: Animals; Binding Sites; Carbon Radioisotopes; Chloroform; Cytochrome P-450 Enzyme System; Female; Histocytochemistry; Kidney; Kidney Cortex; Liver; Male; Mice; Microsomes, Liver; Necrosis; Organ Specificity; Phenobarbital; Piperonyl Butoxide; Sex Factors | 1973 |
Phenobarbital and organic solvent toxicity.
Topics: Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chloroform; Drug Synergism; Environmental Exposure; Ethane; Hydrocarbons, Chlorinated; Hydrocarbons, Halogenated; Injections, Intraperitoneal; Liver; Male; Methane; Methyl Chloride; Phenobarbital; Rats; Solvents; Tetrachloroethylene; Trichloroethylene | 1973 |
Effect of drug pretreatment on CBrCl3-induced liver injury.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Bromine; Chemical and Drug Induced Liver Injury; Chloroform; Drug Interactions; Fatty Liver; Hydrocarbons, Halogenated; Lipid Metabolism; Male; Microsomes, Liver; Necrosis; Peroxides; Phenobarbital; Phenylenediamines; Proadifen; Rats; Spectrophotometry, Ultraviolet; Time Factors; Triglycerides | 1974 |
[Histological, histochemical and electron microscopical findings in foreign substance induced liver hypertrophy in white mice].
Topics: Animals; Chemical and Drug Induced Liver Injury; Chloroform; Endoplasmic Reticulum; Halothane; Hypertrophy; Liver Diseases; Liver Glycogen; Male; Mice; Microscopy, Electron; Mitochondria, Liver; Phenobarbital; Thiopental | 1967 |
An isothermal GLC determination of the plasma levels of carbamazepine, diphenylhydantoin, phenobarbitone and primidone.
Topics: Benzyl Compounds; Carbamazepine; Chloroform; Chromatography, Gas; Humans; Methods; Phenobarbital; Phenytoin; Phthalic Acids; Primidone; Solubility; Spectrophotometry; Ultraviolet Rays | 1972 |
A gas-chromatographic method for separating and measuring barbiturates and glutethimide in blood.
Topics: Amobarbital; Barbiturates; Blood Chemical Analysis; Chloroform; Chromatography, Gas; Evaluation Studies as Topic; Glass; Glutethimide; Hexobarbital; Humans; Hydrogen-Ion Concentration; Mathematics; Mephobarbital; Methods; Methohexital; Methylation; Pentobarbital; Phenobarbital; Secobarbital; Solubility; Spectrophotometry; Time Factors; Ultraviolet Rays | 1971 |
Separation and identification of barbiturates and glutethimide by thin-layer chromatography.
Topics: Amobarbital; Barbiturates; Chemistry, Clinical; Chloroform; Chromatography, Thin Layer; Glutethimide; Hydroxides; Methods; Pentobarbital; Phenobarbital; Secobarbital; Spectrophotometry | 1971 |
Concurrent assay of phenobarbital and diphenylhydantoin in plasma by vapor-phase chromatography.
Topics: Chloroform; Chromatography, Gas; Humans; Hydrogen-Ion Concentration; Methods; Phenobarbital; Phenytoin; Primidone; Solubility; Time Factors | 1970 |
The effect of protein deficiency and microsomal enzyme induction by DDT and phenobarbitone on the acute toxicity of chloroform and a pyrrolizidine alkaloid, retrorsine.
Topics: Alkaloids; Animals; Carbon Tetrachloride; Chloroform; DDT; Enzyme Induction; Heterocyclic Compounds; Liver; Male; Microsomes; Phenobarbital; Protein Deficiency; Rats | 1970 |
Simultaneous spectrophotometric determination of glutethimide and barbiturates.
Topics: Amobarbital; Barbiturates; Chloroform; Glutethimide; Humans; Hydrogen-Ion Concentration; Methods; Pentobarbital; Phenobarbital; Secobarbital; Solubility; Spectrophotometry; Thiopental; Time Factors; Ultraviolet Rays | 1970 |
Modification of the effects of chloroform on the rat liver.
Topics: Animals; Chemical and Drug Induced Liver Injury; Chloroform; Disulfiram; Enzyme Induction; Microsomes, Liver; Necrosis; Phenobarbital; Preanesthetic Medication; Rats; Thiopental; Transaminases | 1970 |
[Stimulation and depression of toxicity of chloroform for the liver by drugs].
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Chloroform; Depression, Chemical; Disulfiram; Drug Synergism; Female; Liver; Liver Diseases; Necrosis; Phenobarbital; Rats; Stimulation, Chemical | 1970 |
[Studies on the influence of inhalation anesthesia and surgery on liver function with special reference to halothane].
Topics: Anesthesia, Inhalation; Anesthetics; Animals; Chloroform; Enzyme Activation; Enzyme Induction; Halothane; Humans; Liver; Liver Diseases; Liver Function Tests; Phenobarbital; Rats; Sulfobromophthalein; Trichloroethylene | 1970 |
The importance of gastric lavage in the treatment of poisoning.
Topics: Amobarbital; Barbiturates; Chloroform; Chromatography, Thin Layer; Forensic Medicine; Gastric Lavage; Humans; Phenobarbital; Phenytoin; Poisoning; Primidone; Secobarbital | 1970 |
[Potentiation and inhibition of chloroform liver toxicity by drugs].
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chloroform; Disulfiram; Drug Antagonism; Drug Synergism; Liver; Necrosis; Phenobarbital; Preanesthetic Medication; Rats | 1971 |
Gas chromatographic assay of underivatized 5,5-diphenylhydantoin (dilantin) in plasma extracts.
Topics: Carbamazepine; Chloroform; Chromatography, Gas; Coma; Epilepsy; Humans; Hydrogen-Ion Concentration; Methods; Phenobarbital; Phenytoin; Primidone | 1971 |
The identification and determination of barbiturates in serum.
Topics: Barbiturates; Buffers; Chloroform; Diagnosis, Differential; Humans; Hydrogen-Ion Concentration; Phenobarbital; Phosphates; Poisoning; Spectrophotometry | 1967 |
Effect of anaesthetics on mature infections of Schistosoma mansoni in the white mouse.
Topics: Amobarbital; Animals; Barbiturates; Chloroform; Ethyl Ethers; Halothane; Hexobarbital; In Vitro Techniques; Liver Circulation; Mesenteric Arteries; Mesenteric Veins; Mice; Pentobarbital; Phenobarbital; Schistosoma; Schistosomiasis; Secobarbital | 1965 |
Differential effects of depressant drugs on presynaptic inhibition.
Topics: Animals; Anticonvulsants; Carbon Dioxide; Cats; Chloral Hydrate; Chloroform; Ethanol; Ethers; Magnesium Sulfate; Mephenesin; Nitrous Oxide; Pentobarbital; Phenobarbital; Procaine; Spinal Cord | 1966 |
Drug effects on the spontaneous electrical activity of the squid giant axon.
Topics: Acetylcholine; Action Potentials; Animals; Anticonvulsants; Atropine; Axons; Barbiturates; Bromides; Chloroform; Chlorpheniramine; Chlorpromazine; Curare; Dopamine; Electrophysiology; Ethanol; Ethers; Evoked Potentials; Hydantoins; Mollusca; Muscles; Nortropanes; Parasympatholytics; Pentylenetetrazole; Phenobarbital; Phenytoin; Picrotoxin; Procaine; Serotonin; Strychnine; Tetracaine; Tremorine; Trihexyphenidyl; Trimethadione | 1967 |
Phospholipids as ion exchangers: implications for a possible role in biological membrane excitability and anesthesia.
Topics: Anesthesia; Binding Sites; Calcium; Chloroform; Hydrogen-Ion Concentration; Ion Exchange; Membranes, Artificial; Metals; Methanol; Models, Biological; Pentobarbital; Phenobarbital; Phenytoin; Phosphatidylethanolamines; Phospholipids; Procaine; Sulfhydryl Compounds | 1967 |
Inhibition of liver-microsome calcium pump by in vivo administration of CCl4, CHCl3 and 1,1-dichloroethylene (vinylidene chloride).
Topics: Animals; Biological Transport, Active; Calcium; Carbon Tetrachloride; Chloroform; Dichloroethylenes; Glucose-6-Phosphatase; Hydrocarbons, Chlorinated; Lipid Peroxides; Male; Microsomes, Liver; Phenobarbital; Rats | 1980 |
Comparative studies on the hepatotoxic actions of chloroform and related halogenomethanes in normal and phenobarbital-pretreated animals.
Topics: Animals; Carbon Tetrachloride; Chloroform; Ditiocarb; Drug Synergism; Hydrocarbons, Halogenated; In Vitro Techniques; Lipid Peroxides; Liver; Male; Methane; Mice; Microsomes, Liver; Phenobarbital; Rats; Transaminases; Triglycerides | 1980 |
Effect of polybrominated biphenyls, beta-naphthoflavone and phenobarbital on arylhydrocarbon hydroxylase activities and chloroform-induced nephrotoxicity and hepatotoxicity in male C57BL/6J and DBA/2J mice.
Topics: Alanine Transaminase; Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; beta-Naphthoflavone; Blood Urea Nitrogen; Chloroform; Dose-Response Relationship, Drug; Enzyme Induction; Flavonoids; Kidney; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Phenobarbital; Polybrominated Biphenyls; Species Specificity | 1984 |
Comparison of the effects of methyl-N-butyl ketone and phenobarbital on rat liver cytochromes P-450 and the metabolism of chloroform to phosgene.
Topics: Animals; Benzphetamine; Chloroform; Chromatography, Ion Exchange; Cytochrome P-450 Enzyme System; Ketones; Male; Methyl n-Butyl Ketone; Microsomes, Liver; Phenobarbital; Phosgene; Rats; Rats, Inbred Strains | 1983 |
Mechanism of chloroform nephrotoxicity. IV. Phenobarbital potentiation of in vitro chloroform metabolism and toxicity in rabbit kidneys.
Topics: Animals; Chloroform; Cytochrome P-450 Enzyme System; Drug Synergism; Enzyme Induction; In Vitro Techniques; Kidney; Kidney Cortex; Kidney Diseases; Male; Microsomes; p-Aminohippuric Acid; Phenobarbital; Phosgene; Pyrrolidonecarboxylic Acid; Rabbits; Tetraethylammonium; Tetraethylammonium Compounds; Thiazoles; Thiazolidines | 1984 |
Phosgene: a possible role in the potentiation of carbon tetrachloride hepatotoxicity by 2-propanol.
Topics: 1-Propanol; Animals; Carbon Dioxide; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Chloroform; Male; Microsomes, Liver; Phenobarbital; Phosgene; Rats | 1981 |
Modification of the hepatotoxicity of carbon tetrachloride and chloroform in goats by pre-treatment with dieldrin and phenobarbitone.
Topics: Animals; Carbon Tetrachloride; Chloroform; Dieldrin; Enzyme Induction; Goats; Liver; Male; Microsomes, Liver; Phenobarbital | 1982 |
Carbon tetrachloride-mediated expiration of pentane and chloroform by the intact rat: the effects of pretreatment with diethyl maleate, SKF-525A and phenobarbital.
Topics: Animals; Carbon Tetrachloride; Chloroform; Drug Interactions; Glutathione; Lipid Peroxides; Male; Maleates; Pentanes; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains | 1982 |
Effects of differential changes in rat hepatic and renal cytochrome P-450 concentrations on hepatotoxicity and nephrotoxicity of chloroform.
Topics: Animals; Cadmium; Chloroform; Cytochrome P-450 Enzyme System; Fasting; Kidney; Liver; Male; Necrosis; Phenobarbital; Rats | 1981 |
Effect of cysteine, diethyl maleate, and phenobarbital treatments on the hepatotoxicity of [1H]chloroform.
Topics: Alanine Transaminase; Animals; Biotransformation; Chloroform; Cysteine; Liver; Male; Maleates; Phenobarbital; Phosgene; Rats; Rats, Inbred Strains | 1981 |
Metabolism of haloforms to carbon monoxide. IV. studies on the reaction mechanism in vivo.
Topics: Animals; Carbon Monoxide; Carcinogens; Chloroform; Cysteine; Deuterium; Hydrocarbons, Brominated; Male; Maleates; Phenobarbital; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Thiazoles; Thiazolidines; Trihalomethanes | 1981 |
Effects of alterations in drug metabolism on chloroform-induced cardiac arrhythmias in rabbits.
Topics: Animals; Arrhythmias, Cardiac; Biphenyl Compounds; Chloroform; Cytochrome P-450 Enzyme System; Diethylamines; Drug Interactions; Epinephrine; Male; Phenobarbital; Proadifen; Rabbits | 1981 |
Effect of tetrachloromethane and other chlorinated hydrocarbons on the hepatic metabolism in the isolated perfused rat liver.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chloroform; Hydrocarbons, Chlorinated; L-Iditol 2-Dehydrogenase; Liver; Male; Methylene Chloride; Phenobarbital; Rats; Rats, Inbred Strains; Trichloroethanes; Trichloroethylene | 1981 |
Chloroform-induced glutathione depletion and toxicity in freshly isolated hepatocytes.
Topics: Alkylation; Animals; Cell Membrane Permeability; Chloroform; Glutathione; In Vitro Techniques; Lipid Peroxides; Liver; Male; Phenobarbital; Protein Binding; Proteins; Rats | 1980 |
Mechanism of the microsomal reduction of carbon tetrachloride and halothane.
Topics: Animals; Benzopyrenes; Biotransformation; Carbon Tetrachloride; Chloroform; Deuterium; Gas Chromatography-Mass Spectrometry; Halothane; Hydrogen; Male; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Rats | 1981 |
Different contributions of cytochrome P450 2E1 and P450 2B1/2 to chloroform hepatotoxicity in rat.
Topics: Alanine Transaminase; Animals; Antibodies, Monoclonal; Antibody Formation; Aryl Hydrocarbon Hydroxylases; Benzyl Alcohol; Benzyl Alcohols; Body Weight; Chloroform; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Hexanes; Immunoblotting; Liver; Male; Methyl n-Butyl Ketone; Microsomes, Liver; Organ Size; Oxidoreductases, N-Demethylating; Phenobarbital; Rats; Rats, Wistar; Steroid Hydroxylases; Toluene | 1995 |
In vivo production of different chloroform metabolites: effect of phenobarbital and buthionine sulfoximine pretreatment.
Topics: Animals; Buthionine Sulfoximine; Chloroform; Injections, Intraperitoneal; Male; Methionine Sulfoximine; Microsomes, Liver; Phenobarbital; Phospholipids; Rats; Rats, Sprague-Dawley | 1994 |
The role of different cytochrome P450 isoforms in in vitro chloroform metabolism.
Topics: Acetone; Animals; Aryl Hydrocarbon Hydroxylases; beta-Naphthoflavone; Biotransformation; Chloroform; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Dexamethasone; Drug Synergism; Enzyme Induction; Isoenzymes; Male; Microsomes, Liver; Phenobarbital; Pyrazoles; Rats; Rats, Sprague-Dawley; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases | 1996 |
Central nervous system depressant effect of Hoslundia opposita vahl.
Topics: Animals; Anticonvulsants; Behavior, Animal; Central Nervous System Depressants; Chloroform; Drug Synergism; Hypnotics and Sedatives; Lamiaceae; Male; Mice; Nigeria; Phenobarbital; Plant Extracts; Plant Roots; Plants, Medicinal; Solvents | 1999 |
Optimization of an exogenous metabolic activation system for FETAX. II. Preliminary evaluation.
Topics: Abnormalities, Drug-Induced; Animals; beta-Naphthoflavone; Biotransformation; Carbon Tetrachloride; Chloroform; Coculture Techniques; Embryo, Mammalian; Embryo, Nonmammalian; Isoniazid; Microsomes, Liver; Parathion; Phenacetin; Phenobarbital; Rats; Toxicity Tests; Urethane; Xenopus laevis | 2001 |
[Prolonged coma (10 days) due to massive phenobarbital (25 g) poisoning: prolonged apnea (4 days); artificial respiration. Recovery].
Topics: Apnea; Barbiturates; Cardiac Glycosides; Cell Respiration; Chloroform; Coma; Humans; Phenobarbital; Respiration; Respiration, Artificial | 1963 |
THE GLUCOSE CONTENT OF BRAIN IN ANAESTHESIA.
Topics: Anesthesia; Animals; Blood Glucose; Brain; Chloroform; Chlorpromazine; Ether; Glucose; Lactates; Mice; Pharmacology; Phenobarbital; Research | 1964 |
CENTRAL AND PERIPHRAL ACTIONS OF PRONETHALOL.
Topics: Arrhythmias, Cardiac; Blood Pressure; Chloroform; Electrocardiography; Epinephrine; Ethanolamines; Ethers; Guinea Pigs; Heart Rate; Hypotension; Isoproterenol; Pentobarbital; Pharmacology; Phenobarbital; Phentolamine; Pituitary Hormones; Pituitary Hormones, Posterior; Pressoreceptors; Reflex; Research; Sympatholytics; Toxicology; Urethane; Vasomotor System | 1965 |