phenobarbital has been researched along with carbon tetrachloride in 251 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 179 (71.31) | 18.7374 |
| 1990's | 49 (19.52) | 18.2507 |
| 2000's | 16 (6.37) | 29.6817 |
| 2010's | 6 (2.39) | 24.3611 |
| 2020's | 1 (0.40) | 2.80 |
| Authors | Studies |
|---|---|
| Abellán Guillén, A; Cordeiro, MN; Garrido Escudero, A; Morales Helguera, A; Pérez-Garrido, A | 1 |
| Glen, RC; Lowe, R; Mitchell, JB | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Uehleke, H; Werner, T | 1 |
| Cascorbi, HF; Gorsky, BH; Redford, JE | 1 |
| Tappel, AL; Taylor, SL | 1 |
| Fujita, H | 1 |
| Feuer, G; Kellen, JA; Kovacs, K | 1 |
| Nakayama, S | 1 |
| Head, B; Moody, DE; Smuckler, EA | 1 |
| Castro, JA; Diaz Gomez, MI | 1 |
| Acheampong-Mensah, D; Feuer, G | 1 |
| Chopra, P; Das, PK; Dhar, A; Nayak, NC | 1 |
| Cascorbi, HF; Gorsky, BH | 1 |
| Conney, AH; Kuntzman, R; Levin, W | 1 |
| Baich, A; Chen, PC | 1 |
| Barth, ML; Cornish, HH; Ling, B | 1 |
| Anders, MW; Lindstrom, TD | 1 |
| de la Iglesia, FA; Feuer, G; Ilyas, MS | 2 |
| Andersen, ME; Jenkins, LJ; Jones, RA | 1 |
| Endo, M; Ishi, A; Mineura, K; Oishi, T | 1 |
| King, LJ; Mallett, AK; Walker, R | 1 |
| Lopez-Novoa, JM; Rengel, MA | 1 |
| Gans, JH; Herman, J; Korson, R | 1 |
| Hornbrook, KR; McCay, PB; Weddle, CC | 1 |
| Kamath, SA; Rubin, E | 3 |
| Hasumura, Y; Lieber, CS; Teschke, R | 1 |
| Bianco, AR; Budillon, G; Mazzacca, G; Perillo, N | 1 |
| Hes, J; Sternson, LA | 1 |
| Drew, RT; Fouts, JR; Lo, RJ; Roth, RP | 1 |
| Torrielli, MV; Ugazio, G | 1 |
| Carlson, GP; Fuller, GC; Suarez, KA | 1 |
| Moslen, MT; Reynolds, ES | 1 |
| Docks, EL; Krishna, G | 1 |
| Faroon, OM; Kodavanti, PR; Kodavanti, UP; Mehendale, HM | 1 |
| Columbano, A; Coni, P; Curto, M; Faa, G; Giacomini, L; Ledda-Columbano, GM; Sarma, DS | 1 |
| Jeney, A; Kovalszky, I; Lapis, K; Szeberenyi, S; Vincze, I; Zalatnai, A | 1 |
| Amanuma, T; Denda, A; Konishi, Y; Maruyama, H; Nakae, D; Takashima, Y; Tsujiuchi, T; Tsutsumi, M; Yoshiji, H | 1 |
| Awad, JA; Badr, KF; Burk, RF; Kato, T; Morrow, JD; Roberts, LJ; Takahashi, K | 1 |
| Belgiorno, J; Dagenais, M; Giroux, L; Huet, PM | 1 |
| Min, KS; Onosaka, S; Tanaka, K; Terano, Y | 1 |
| Faulkner, M; Ingleton, PM; Parsons, MA; Rodgers, GR | 1 |
| Buters, JT; Reichen, J; Roos, FJ; Sojcic, Z | 1 |
| Cai, ZW; Mehendale, HM | 1 |
| Kodavanti, PR; Kodavanti, UP; Mehendale, HM | 1 |
| Cai, Z; Mehendale, HM | 1 |
| Cope, BC; McGowan, LT; Payne, E; Smith, JF | 1 |
| Benbrahim, N; Dubé, C; Ethier, C; Gascon-Barré, M; Tremblay, C; Vallières, S | 1 |
| Ahren, B; Alumets, J; Bengmark, S; Foss, A; Jeppsson, B; Rozga, J | 1 |
| Fischer-Nielsen, A; Hage, E; Hansen, BA; Keiding, S; Poulsen, HE | 1 |
| Lapis, K; Lapsis, K; Rot, A; Sárosi, I; Zalatnai, A | 1 |
| Nadkarni, GD; Noronha, OP; Shimpi, HH | 1 |
| Borzelleca, JF; Clarke, EC; Condie, LW; Gennings, C; O'Hara, TM; Sheppard, MA | 1 |
| Cousins, MJ; Hall, PM; Ilsley, AH; Jenner, MA; Plummer, JL | 1 |
| Jayatilaka, KA; Perera, DJ; Thabrew, MI | 1 |
| Biasi, F; Chiarpotto, E; Cottalasso, D; Domenicotti, C; Marinari, UM; Melloni, E; Poli, G; Pronzato, MA; Viotti, P | 1 |
| Masuda, Y; Nakamura, Y | 1 |
| James, JL; Moody, DE; Smuckler, EA | 1 |
| Advani, SV; Bidlack, WR; Riebow, JF; Tortoriello, P | 1 |
| Bell, AN; Mehendale, HM | 1 |
| Büsser, MT; Lutz, WK | 1 |
| Klingensmith, JS; Mehendale, HM | 3 |
| Berndt, WO; Christenson, WR; Davis, ME | 1 |
| Chibowski, D; Pawłowska-Wakowicz, B; Siezieniewska, Z; Tryksza, J | 1 |
| Buschmann, RJ; Ryoo, JW | 2 |
| Hughes, H; Mitchell, JR; Smith, CV; Tsokos-Kuhn, JO | 1 |
| Jikkoh, A; Kamiyama, Y; Morimoto, T; Ozawa, K; Taki, Y; Tanaka, J; Tobe, T; Yokoo, N | 1 |
| Karvonen, I; Saarni, HU; Sotaniemi, EA; Stenbäck, F; Stengård, JH | 1 |
| Davies, HW; Pohl, LR; Thomas, PE | 1 |
| Entman, ML; Mitchell, JR; Smith, CV; Tate, CA; Tsokos-Kuhn, JO | 1 |
| Button, J; Clawson, GA; Geller, DA; Hammock, BD; Loury, DN; Moody, DE; Smuckler, EA; Taylor, LA | 1 |
| Alam, SM; Qazi, FM | 1 |
| Divald, A; Jeney, A; Lapis, K; Paku, S; Schaff, Z; Simon, K; Szende, B; Timár, F; Timár, J | 1 |
| Degawa, M; Miura, S; Namiki, M; Ohta, A; Ueno, H | 1 |
| Egger, B; Ohara, N; Reichen, J; Zeltner, TB; Zimmermann, A; Zysset, T | 1 |
| Benediktova, SA; Devichensky, VM; Izotov, MV; Lugovaja, LV; Shcherbakov, VM; Spiridonova, SM | 1 |
| Hoffmann, P; Ponsold, W; Rosenfeld, E | 1 |
| Mori, H; Tanaka, T; Williams, GM | 1 |
| Giraldi, T; Lassiani, L; Perissin, L; Sava, G; Zorzet, S | 1 |
| Burk, RF; Hill, KE; Lane, JM | 1 |
| Becker, E; Berndt, J; Messner, B | 1 |
| Alwmark, A; Greeley, GH; Mamlok, V; Santos, A; Thompson, JC | 1 |
| Ryan, MP; Wosilait, WD | 1 |
| Enosawa, S; Nakazawa, Y | 1 |
| Head, B; James, JL; Moody, DE; Smuckler, EA; Woo, CH | 1 |
| Chiang, HJ; Kuroiwa, Y; Suzuki, T; Yanaura, S; Yoshida, T | 1 |
| Alp, MH; Hickman, R | 1 |
| Fel', VIa; Khodosova, IA; Zakharova, NV | 1 |
| Brunden, MN; Kaluzny, M; Merritt, MV; Rush, B; Ruwart, M; Van Schoick, T | 1 |
| Breimer, DD; de Bree, H; Heij, P; van der Graaff, M; Vermeulen, NP | 1 |
| de Gerlache, J; Lans, M; Préat, V; Roberfroid, M; Taper, H | 1 |
| Bien, E; Witt, M | 1 |
| Nakajima, T; Sato, A | 1 |
| Fel', VIa; Khodosova, IA; Kudriatsev, BN; Zakharova, NV | 1 |
| Boisset, M; Boudene, C; Cluet, JL | 1 |
| Ito, M; Kikuchi, S; Matsumoto, H; Yachi, A | 1 |
| de Gerlache, J; Deleener, A; Kirsch-Volders, M; Lans, M | 1 |
| Bardou, LG; Gentric, E; Lauransan, J; Menez, JF; Saumagne, P | 1 |
| Loeser, W; Siegers, CP | 1 |
| Brown, BR; Gandolfi, AJ; Lind, RC; Sipes, IG | 1 |
| Anders, MW; Aniya, Y | 1 |
| Siegers, CP; Younes, M | 1 |
| Lombardi, B; Ove, P; Reddy, TV | 1 |
| Hochstrate, C; Oberdisse, E | 1 |
| Davis, DC; Gillette, JR; Sasame, HA | 1 |
| Cooper, SD; De la Iglesia, FA; Feuer, G; Lumb, G | 1 |
| Adam, SE; Ford, EJ; Gopinath, C | 1 |
| Busuttil, A; Horne, CH; MacSween, RN; Thompson, WD | 1 |
| Burgison, RM; Dietz, AJ | 1 |
| Castro, JA; Gomez, MI | 1 |
| Rösen, P; Stier, A | 1 |
| Feuer, G; Granda, V | 1 |
| Heni, N; Remmer, H | 2 |
| Delaney, VB; Slater, TF | 1 |
| Cooper, SD; Feuer, G | 2 |
| Castro, JA; D'Acosta, N; De Castro, CR; De Ferreyra, EC; Diaz Gomez, MI | 1 |
| Schnitger, F; Uehleke, H | 1 |
| Gillette, JR | 1 |
| Davis, DC; Gillette, JR; Gram, TE; Reagan, RL; Schroeder, DH | 1 |
| Brodie, BB; Cho, AK; Krishna, G; Reid, WD | 1 |
| Heni, N | 1 |
| McIntosh, DA; Topham, JC | 1 |
| Cascorbi, HF; Singh-Amaranath, AV | 1 |
| Jenkins, LJ; Murphy, SD; Trabulus, MJ | 1 |
| Kamm, JJ; Szuna, A | 1 |
| Grant, DL; Hatina, GV; Mendoza, CE; Panopio, LG; Phillips, WE; Villeneuve, DC | 1 |
| Klinger, W; Müller, D | 1 |
| Kew, MC; Kilroe-Smith, TA; Serebro, LH | 1 |
| Papacharalampous, NX; Tsironis, A | 1 |
| Wirtz, KW | 1 |
| Alston, WC; Busuttil, A; Horne, CH; MacSween, RN | 1 |
| Alvin, J; Breen, KJ; Henderson, GI; Hoyumpa, AM; Schenker, S; Shaw, J | 1 |
| Farber, TM; Litterst, CL; Van Loon, EJ | 1 |
| Castro, JA; D'Acosta, N; de Castro, CR; de Fenos, OM; de Ferreyra, EC; Díaz Gòmez, MI | 1 |
| Barth, ML; Cornish, HH; Ling, BP | 1 |
| Filippich, LJ; Seawright, AA; Steele, DP | 1 |
| Cohen, G; Lieberman, M; Riely, CA | 1 |
| Hickman, R; Saunders, SJ; Terblanche, J; van Leenhoff, JA | 1 |
| Arcasoy, M; Smuckler, EA | 1 |
| Oester, YT; Prabhu, VG; Rise, NL | 1 |
| Dixon, JR; Moffitt, AE; Phipps, FC; Stokinger, HE | 1 |
| Hurwitz, A | 1 |
| Bishop, R; Mudie, AW; Seawright, AA; Steele, DP | 1 |
| Heath, D; Kay, JM; Khaliq, SU | 1 |
| Mirvish, SS; Sidransky, H | 1 |
| Prabhu, VG | 1 |
| Kato, R | 1 |
| Wirtz, KW; Zilversmit, DB | 1 |
| McLean, AE; McLean, EK; Sutton, PM | 1 |
| Marshall, WJ; McLean, AE; McLean, EK; Sutton, PM | 1 |
| McLean, AE | 1 |
| Marchand, C; McLean, S; Plaa, GL | 1 |
| Miller, RA; Stenger, RJ; Williamson, JN | 1 |
| Fowler, JS | 1 |
| Gillette, JR; Kamm, JJ; Sasame, HA | 1 |
| Garner, RC | 1 |
| McLean, AE; Seawright, AA | 1 |
| Kobayashi, M; Nagashima, H; Nakatsukasa, H; Watanabe, A | 1 |
| Bernacchi, AS; Castro, JA; de Castro, CR; Fernández, G; Villarruel, MC | 1 |
| Davis, ME; Mehendale, HM | 1 |
| Klingensmith, JS; Lockard, V; Mehendale, HM | 1 |
| Agarwal, AK; Mehendale, HM | 2 |
| Moore, L | 1 |
| Masuda, Y; Murano, T; Yano, I | 1 |
| Fander, U; Haas, W; Kröner, H | 1 |
| Hagiwara, A; Hasegawa, R; Ito, N; Shirai, T; Tatematsu, M; Tsuda, H | 1 |
| Mowat, AP; Trivedi, P | 1 |
| Gadeholt, G | 1 |
| Jess, U; Siegers, CP; Younes, M | 1 |
| Alley, MC; Appel, PL; Kooistra, KL; Lieber, MM; Powis, G | 1 |
| Farrell, GC; Murray, M | 1 |
| Hietanen, E; Koivusaari, U; Lang, M | 1 |
| Hobara, N; Watanabe, A | 1 |
| Boyd, MR; Burka, LT; Sastry, BV; Wilson, BJ | 1 |
| Anders, MW; Harris, RN | 2 |
| Abdelsalam, EB; Adam, SE; Tartour, G | 1 |
| Ahotupa, M; Heikelä, A; Hietanen, E; Laitinen, M | 1 |
| Gans, JH; Mulcahy, LS | 1 |
| Ahotupa, M; Heikelä, A; Hietanen, E; Laitinen, M; Nienstedt, W | 1 |
| Kusek, JC | 1 |
| Gordon, AS; Hjelle, JJ; Petersen, DR | 1 |
| Alexander, SS; Fong, KL; King, MM; Lai, EK; McCay, PB; Noguchi, T; Olson, L; Poyer, JL | 1 |
| Frank, H; Haussmann, HJ; Remmer, H | 1 |
| Bechtold, MM; Bruenner, U; Gee, DL; Tappel, AL | 1 |
| Chatamra, K; Proctor, E | 2 |
| Anderson, RJ; Berl, T; Guggenheim, SJ; Linas, SL; Robertson, GL | 1 |
| Jones, DH; Kim, HL | 1 |
| Buckiová, D; Musil, J; Nováková, V; Sollová, H; Táborský, O; Výborný, P | 1 |
| Awazu, S; Hanano, M; Hayashi, M; Sawada, Y | 1 |
| Buckiová, D; Musil, J; Nováková, O | 1 |
| Morita, I; Murota, S | 1 |
| Advani, SV; Andresen, JW; Bidlack, WR | 1 |
| Anders, MW; Kubic, VL | 1 |
| Marti, U; Oguey, D; Reichen, J | 1 |
| Branch, RA; Sabra, R; Wensing, G | 1 |
| Ding, WG; Kimura, H; Kuriyama, K; Tooyama, I | 1 |
| Lapis, K; Zalatnai, A | 2 |
| Brauer, M; Locke, SJ; Lu, W | 1 |
| Aisen, AM; Doi, K; Swanson, SD | 1 |
| Kuwabara, Y; Watanabe, A | 1 |
| Brazier, JL; Géloën, A; Minaire, Y; Mion, F; Rousseau, M | 1 |
| Bosio, A; Burdino, E; Dacasto, M; Nebbia, C; Ugazio, G; van't Klooster, G | 1 |
| Buters, JT; Reichen, J; Zysset, T | 1 |
| Castelain, P; Ghahroudi, MA; Kirsch-Volders, M; Van Goethem, F | 1 |
| Masuda, Y; Ozaki, M | 1 |
| Ding, WG; Kimura, H; Kuriyama, K; Ochi, J; Tooyama, I | 1 |
| Cattley, RC; Glover, SE; Miller, RT; Murkofsky, RL; Popp, JA | 1 |
| Atuchá, NM; Garcia-Estañ, J; Quesada, T | 1 |
| Huang, R; Inoue, K; Okuno, H; Shiozaki, Y; Takasu, M | 1 |
| Timbrell, JA; Waterfield, CJ | 1 |
| Gunawardhana, L; Hill, DA; Sauer, JM; Sipes, IG; Stine, ER | 1 |
| Fujiwara, K; Ogata, I; Tomiya, T | 1 |
| Kaneko, H; Masuda, Y; Oguma, T | 1 |
| Hashimoto, M; Kothary, PC; Raper, SE | 1 |
| Brault, D; Guffroy, M; Périn, F; Renault, D; Thybaud, V; Tombolan, F | 1 |
| Dufour, JF; Forestier, M; Lüthi, M; Magnino, F | 1 |
| Fölsch, UR; Gallwitz, B; Klöppel, G; Reinecke-Lüthge, A; Schmidt, WE; Schmitz, F; Seidenstücker, A; Siegel, EG | 1 |
| Ciliberto, G; DeAngelis, RA; Furth, EE; Kovalovich, K; Li, W; Taub, R | 1 |
| Cai, J; Fox, IJ; Gao, C; Hammel, JM; Ito, M; Kobayashi, N; Nakamura, J | 1 |
| Castilla-Cortázar, I; Cemborain, A; Delgado, G; Díaz-Sánchez, M; García, M; Muguerza, B; Picardi, A | 1 |
| Cai, J; Cao, C; Fox, IJ; Hammel, JM; Ito, M; Kobayashi, N; Nakamura, J | 1 |
| Menger, MD; Mücke, I; Richter, S; Vollmar, B | 1 |
| Finch, RA; Fort, DJ; Paul, RR; Rogers, RL; Stover, EL | 1 |
| Anand, M; Das, M; Khanna, RN | 1 |
| Akagi, R; Fujii, H; Maeshima, K; Morita, K; Nakahira, K; Nakatsuka, H; Shimizu, H; Takahashi, T; Uehara, K; Yokoyama, M | 1 |
| FUJIMOTO, JM; PLAA, GL | 1 |
| Bornstein, SR; Fölsch, UR; Kloehn, S; Mönig, H; Otte, C; Otte, JM; Strodthoff, D | 1 |
| Horiguchi, N; Kakizaki, S; Mori, M; Negishi, M; Takagi, H; Yamazaki, Y | 1 |
| Ferencz, V; Folhoffer, A; Gaál, J; Hegedus, D; Horváth, A; Horváth, C; Kári, B; Mészáros, S; Szalay, F; Wolf, Z | 1 |
| Alavaikko, M; Arvela, P; Vorne, M | 1 |
| Ali, MS; Bepary, S; Chowdhury, AA; Das, BK; Datta, BK; Rouf, AS | 1 |
| Girish, C; Jayanthi, S; Koner, BC; Pradhan, SC; Rajesh, B; Rao, KR | 1 |
| Chan, PK; Chan, WH; Chou, CP; Liao, JW; Ueng, TH; Wei, CF | 1 |
| Chen, YH; Du, BQ; Liu, XB; Mai, G; Xiang, GM; Zheng, ZJ | 1 |
| Bellance, N; Bing, H; Damm, A; Fox, IJ; Handa, K; Moss, TJ; Nagrath, D; Nishikawa, T; Oertel, M; Pipinos, II; Ram, PT; Sehgal, V; Soto-Gutierrez, A; Yovchev, MI; Zhu, Z | 1 |
| Berardis, S; El Taghdouini, A; El-Kehdy, H; Evraerts, J; Henriet, P; Lombard, C; Najimi, M; Rosseels, V; Sokal, EM; van Grunsven, L | 1 |
| Bosch, J; Boyer-Diaz, Z; Gracia-Sancho, J; Lozano, JJ; Maeso-Díaz, R; Ortega-Ribera, M; Peralta, C | 1 |
| Fujino, C; Hayashi, K; Katsura, T; Kubo, Y; Kuzu, T; Ueshima, S | 1 |
6 review(s) available for phenobarbital and carbon tetrachloride
| Article | Year |
|---|---|
Cytochrome P-450 and its role in drug metabolism.
Topics: Adrenalectomy; Animals; Carbon Tetrachloride; Cytochromes; Dealkylation; Deamination; Enzyme Induction; Female; Glucocorticoids; Hydroxylation; Male; Mice; Microsomes, Liver; NADP; Oxidation-Reduction; Oxidoreductases; Oxygen Consumption; Pharmaceutical Preparations; Phenobarbital; Phospholipids; Polycyclic Compounds; Pseudomonas; Rats; Sex Factors; Spectrum Analysis; Spironolactone; Ultraviolet Rays | 1972 |
Transfer of phospholipids between membranes.
Topics: Amino Acids; Animals; Biological Transport; Brain; Carbon Tetrachloride; Cell Membrane; Cytosol; Dogs; Erythrocytes; Humans; Kinetics; Lipoproteins; Liver; Membranes; Microsomes, Liver; Mitochondria; Mitochondria, Liver; Phenobarbital; Phospholipids; Phosphorus Radioisotopes; Receptors, Drug; Tritium; Ultracentrifugation | 1974 |
Microsomes, metabolism and toxicity.
Topics: Animals; Barbiturates; Biotransformation; Carbon Tetrachloride; DDT; Enzyme Induction; Female; Hexobarbital; Male; Methylcholanthrene; Mice; Microsomes, Liver; Pesticides; Phenobarbital; Pituitary Hormones, Anterior; Protein Deficiency; Rabbits; Rats; Steroids; Toxicology | 1969 |
Structural and functional changes of the endoplasmic reticulum of hepatic parenchymal cells.
Topics: Animals; Azo Compounds; Carbon Tetrachloride; Carcinogens; Cattle; Dogs; Endoplasmic Reticulum; Ethionine; Fetus; Glycogen; Guinea Pigs; Haplorhini; Hormones; Humans; Lipid Metabolism; Liver; Mice; Microscopy, Electron; Microsomes; Nutrition Disorders; Phenobarbital; Protein Biosynthesis; Rabbits; Rats; Ribosomes; RNA; Sex Factors; Species Specificity; Ultracentrifugation | 1969 |
Immunohistochemical localization of taurine-conjugated bile acids in the liver of mouse, rat, monkey and human.
Topics: Animals; Bile Acids and Salts; Carbon Tetrachloride; Haplorhini; Humans; Immunohistochemistry; Liver; Mice; Phenobarbital; Rats; Species Specificity; Taurine; Tissue Distribution | 1994 |
The liver as a target for chemical-chemical interactions.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chlorobenzenes; Drug Antagonism; Drug Interactions; Drug Synergism; Drug-Related Side Effects and Adverse Reactions; Humans; Naphthalenes; Phenobarbital | 1997 |
245 other study(ies) available for phenobarbital and carbon tetrachloride
| Article | Year |
|---|---|
Convenient QSAR model for predicting the complexation of structurally diverse compounds with beta-cyclodextrins.
Topics: beta-Cyclodextrins; Hydrophobic and Hydrophilic Interactions; Organic Chemicals; Quantitative Structure-Activity Relationship | 2009 |
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
A comparative study on the irreversible binding of labeled halothane trichlorofluoromethane, chloroform, and carbon tetrachloride to hepatic protein and lipids in vitro and in vivo.
Topics: 1-Propanol; Aerobiosis; Age Factors; Anaerobiosis; Animals; Carbon Tetrachloride; Chloroform; Cobalt; Cytochrome P-450 Enzyme System; Endoplasmic Reticulum; Halothane; Humans; In Vitro Techniques; Lipid Metabolism; Liver; Methylcholanthrene; Mice; Microsomes, Liver; Mitochondria, Liver; NADP; Phenobarbital; Protein Binding; Rabbits; Rats; Species Specificity | 1975 |
Sex differences in anaesthetic toxicity: fluroxene and trifluoroethanol in mice.
Topics: Animals; Carbon Tetrachloride; Estradiol; Ethanol; Ethers; Female; Male; Mice; Phenobarbital; Preanesthetic Medication; Sex; Testosterone; Trifluoroethanol | 1976 |
Effect of dietary antioxidants and phenobarbital pretreatment on microsomal lipid peroxidation and activation by carbon tetrachloride.
Topics: Animals; Carbon Tetrachloride; Cytochrome P-450 Enzyme System; Diet; Fatty Acids; Kinetics; Lipid Metabolism; Male; Microsomes, Liver; NADP; NADPH-Ferrihemoprotein Reductase; Peroxidases; Phenobarbital; Rats; Selenium; Vitamin E | 1976 |
Anticancer agents and glutathione--from the standpoint of their pharmacokinetics.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Bleomycin; Carbon Tetrachloride; Chloramphenicol; Cyclophosphamide; Drug Interactions; Drug Synergism; Glutathione; Humans; Mitomycins; Phenobarbital | 1977 |
Is there any association between the pharmacologic control of prolactin release and its action on mammary carcinogenesis in the rat?
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carbon Tetrachloride; Coumarins; Female; Mammary Neoplasms, Experimental; Phenobarbital; Prolactin; Rats | 1977 |
[Effects of diispropyl 1, 3-dithiol-2-ylidene malonate (NKK-105) on the drug-metabolizing enzymes and fine structure of rat liver (author's transl)].
Topics: Aminopyrine N-Demethylase; Animals; Carbon Tetrachloride; Cytochrome P-450 Enzyme System; Ethionine; Lipid Peroxides; Liver; Male; Malonates; Microscopy, Electron; Microsomes, Liver; Mitochondria, Liver; Organ Size; Phenobarbital; Rats; Thiophenes | 1979 |
Reduction in hepatic microsomal cytochromes P-450 and b5 in rats exposed to 1,2-dibromo-3-chloropropane and carbon tetrachloride: enhancement of effect by pretreatment with phenobarbital.
Topics: Animals; Carbon Tetrachloride; Cytochrome P-450 Enzyme System; Cytochromes; Cytochromes b5; Hydrocarbons, Halogenated; Liver; Male; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Organ Size; Phenobarbital; Propane; Proteins; Rats; Spectrophotometry | 1979 |
Further studies on the mechanism of the carbon tetrachloride induced polysome breakdown.
Topics: Age Factors; Amitrole; Animals; Carbon Tetrachloride; Cycloheximide; In Vitro Techniques; Liver; Male; Malonates; Methylcholanthrene; Mice; Mice, Inbred A; Niacinamide; Phenobarbital; Polyribosomes; Proadifen; Pyrazoles; Rats | 1976 |
Action of phenobarbital and carbon tetrachloride on hepatic microsomal inosine diphosphatase in the rat.
Topics: Animals; Carbon Tetrachloride; In Vitro Techniques; Inosine; Male; Membranes; Microsomes, Liver; Phenobarbital; Phospholipids; Phosphoric Monoester Hydrolases; Polyethylene Glycols; Proteins; Rats | 1975 |
Diverse mechanisms of hepatocellular injuries due to chemicals: evidence in rats administered carbon tetrachloride or dimethylnitrosamine.
Topics: Age Factors; Animals; Animals, Newborn; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Fetus; Glucose-6-Phosphatase; Hepatectomy; Liver; Liver Diseases; Necrosis; Nitrosamines; Phenobarbital; Rats; Triglycerides | 1975 |
Halothane hepatotoxicity and fluoride production in mice and rats.
Topics: Animals; Biotransformation; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Fluorides; Halothane; Hypoxia; Male; Mice; Oxygen; Phenobarbital; Rats; Species Specificity; Thiopental | 1979 |
Stimulatory effect of phenobarbital on the metabolism of the oral contraceptive 17 alpha-ethynylestradiol-3-methyl ether (mestranol) by rat liver microsomes.
Topics: Animals; Carbon Tetrachloride; Dealkylation; Female; In Vitro Techniques; Male; Mestranol; Microsomes, Liver; Phenobarbital; Rats; Stimulation, Chemical; Uterine Contraction | 1979 |
Cirrhosis and the synthesis of proline and glycine in rat liver.
Topics: Animals; Carbon Tetrachloride; Collagen; Drug Interactions; Glycine; Liver; Liver Cirrhosis, Experimental; Male; Phenobarbital; Pigments, Biological; Proline; Rats | 1979 |
Influence of aliphatic alcohols on the hepatic response to halogenated olefins.
Topics: Alcohols; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chloroform; Drug Synergism; Environmental Exposure; Ethanol; Hydrocarbons, Chlorinated; Liver; Phenobarbital; Rats; Trichloroethylene | 1977 |
Effect of agents known to alter carbon tetrachloride hepatotoxicity and cytochrome P-450 levels on carbon tetrachloride-stimulated lipid peroxidation and ethane expiration in the intact rat.
Topics: 1-Propanol; Animals; Breath Tests; Carbon Tetrachloride; Cobalt; Drug Interactions; Ethane; Ethanol; Lipid Metabolism; Male; Maleates; Methylcholanthrene; Peroxides; Phenobarbital; Rats | 1978 |
The effect of phenobarbital and carbon tetrachloride on fatty acid content and composition of phospholipids from the endoplasmic reticulum of rat liver.
Topics: Animals; Carbon Tetrachloride; Endoplasmic Reticulum; Fatty Acids; Liver; Male; Microsomes, Liver; Phenobarbital; Phospholipids; Rats | 1978 |
The effect of phenobarbital and carbon tetrachloride on fatty acid content and composition of phospholipids from rat liver.
Topics: Animals; Carbon Tetrachloride; Chromatography, Gas; Fatty Acids; Liver; Male; Phenobarbital; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipids; Rats | 1978 |
The acute toxicity of single, oral doses of 1,1-dichloroethylene in the fasted, male rat: effect of induction and inhibition of microsomal enzyme activities on mortality.
Topics: Animals; Bromobenzenes; Carbon Tetrachloride; Dichloroethylenes; Hydrocarbons, Chlorinated; Male; Microsomes, Liver; Phenobarbital; Proadifen; Pyrazoles; Rats | 1978 |
[Metabolism of glybuzole(2-benzenesulfonamido-5-tert-butyl-1-thia-3,4-diazole) in rats after pretreatment of phenobarbital, SKF 525A and carbon tetrachloride (author's transl)].
Topics: Administration, Oral; Animals; Carbon Tetrachloride; Male; Phenobarbital; Proadifen; Rabbits; Rats; Sulfonamides; Thiadiazoles | 1978 |
The apparent non-identity of cytochrome c reductase and flavin-dependent azoreductase activities [proceedings].
Topics: Animals; Azo Compounds; Carbon Tetrachloride; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Flavins; Male; Microsomes, Liver; NADH, NADPH Oxidoreductases; Phenobarbital; Rats; Trypsin | 1978 |
A micropuncture study of salt and water retention in chronic experimental cirrhosis.
Topics: Animals; Carbon Tetrachloride; Diuresis; Glomerular Filtration Rate; Inulin; Kidney; Liver Cirrhosis, Experimental; Male; Phenobarbital; Potassium; Rats; Regional Blood Flow; Sodium | 1977 |
Enhancement by phenobarbital of some effects of carbon tetrachloride on mouse liver.
Topics: Animals; Carbon Tetrachloride; DNA; Drug Synergism; Lipids; Liver; Male; Mice; Organ Size; Phenobarbital; Phenylalanine; Protein Biosynthesis; Pyruvates | 1976 |
Lipid peroxidation and alteration of membrane lipids in isolated hepatocytes exposed to carbon tetrachloride.
Topics: Animals; Carbon Tetrachloride; In Vitro Techniques; Kinetics; Lipid Metabolism; Liver; Male; Malondialdehyde; Peroxides; Phenobarbital; Rats | 1976 |
The use of cation-bound microsomes for studies of protein synthesis.
Topics: Animals; Calcium; Carbon Tetrachloride; Cations, Divalent; Centrifugation, Density Gradient; Cycloheximide; Leucine; Liver; Magnesium; Microsomes, Liver; Phenobarbital; Polyribosomes; Protein Biosynthesis; Rats; Ribosomes; Sucrose | 1975 |
Hepatic microsomal ethanol-oxidizing system (MEOS): dissociation from reduced nicotinamide adenine dinucleotide phosphate oxidase and possible role of form I of cytochrome P-450.
Topics: Animals; Carbon Tetrachloride; Cytochrome P-450 Enzyme System; Ethanol; Female; In Vitro Techniques; Microsomes, Liver; NADH, NADPH Oxidoreductases; Oxidation-Reduction; Phenobarbital; Rats; Stimulation, Chemical | 1975 |
The source of ascitic fluid in experimental cirrhosis in the rat.
Topics: Animals; Ascitic Fluid; Carbon Tetrachloride; Fluoresceins; Fluoroscopy; Liver Cirrhosis; Male; Peritoneum; Phenobarbital; Rats | 1975 |
Species variations in the metabolism of acetophenone oxime by hepatic enzymes.
Topics: Acetophenones; Amines; Animals; Carbon Tetrachloride; Cricetinae; Cytosol; Depression, Chemical; Hydroxylamines; Liver; Male; Methylcholanthrene; Mice; Microsomes, Liver; Oxidoreductases; Oximes; Phenobarbital; Rabbits; Rats; Species Specificity; Stimulation, Chemical | 1975 |
Dichloromethane inhalation, carboxyhemoglobin concentrations, and drug metabolizing enzymes in rabbits.
Topics: Animals; Carbon Tetrachloride; Carboxyhemoglobin; Hemoglobins; Hydrocarbons, Chlorinated; Male; Methylcholanthrene; Methylene Chloride; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Pregnenolone Carbonitrile; Proadifen; Rabbits | 1975 |
Biochemical aspects of the protective action of propyl gallate on liver injury in rats poisoned with carbon tetrachloride.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Body Temperature; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Fatty Acids, Nonesterified; Gallic Acid; Hexobarbital; Isocitrate Dehydrogenase; Lipid Metabolism; Male; Palmitic Acids; Peroxides; Phenobarbital; Propyl Gallate; Rats; Sleep; Time Factors; Triglycerides | 1975 |
Effect of phenobarbital or 3-methylcholanthrene pretreatment on carbon tetrachloride-induced lipid peroxidation in rat liver.
Topics: Animals; Carbon Tetrachloride; In Vitro Techniques; Lipid Metabolism; Liver; Male; Malondialdehyde; Methylcholanthrene; Microsomes, Liver; Peroxides; Phenobarbital; Rats | 1975 |
Metabolism of (14C-1)-halothane in vivo--effects of multiple halothane anesthesia, phenobarbital and carbon tetrachloride pretreatment.
Topics: Anesthesia; Animals; Carbon Tetrachloride; Halothane; Liver; Male; Microsomes, Liver; Phenobarbital; Protein Binding; Rats; Respiration; Time Factors | 1975 |
The role of glutathione in chloroform-induced hepatotoxicity.
Topics: Acetone; Alkanes; Animals; Carbon Tetrachloride; Chloroform; Cysteamine; Cysteine; Dose-Response Relationship, Drug; Glutathione; Kidney; Lens, Crystalline; Liver; Male; Maleates; Methylcholanthrene; Phenobarbital; Propranolol; Rats | 1976 |
Pivotal role of hepatocellular regeneration in the ultimate hepatotoxicity of CCl4 in chlordecone-, mirex-, or phenobarbital-pretreated rats.
Topics: Animals; Autoradiography; Carbon Tetrachloride; Cell Size; Chemical and Drug Induced Liver Injury; Chlordecone; DNA; Drug Synergism; Liver; Liver Diseases; Liver Regeneration; Male; Mirex; Mitosis; Phenobarbital; Rats; Rats, Sprague-Dawley; Thymidine; Time Factors; Tritium | 1992 |
Mitogen-induced liver hyperplasia does not substitute for compensatory regeneration during promotion of chemical hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Cell Division; Diethylnitrosamine; gamma-Glutamyltransferase; Hyperplasia; Lead; Liver; Liver Neoplasms, Experimental; Liver Regeneration; Male; Nitrates; Orotic Acid; Phenobarbital; Rats; Rats, Inbred Strains | 1992 |
Modification of DENA-induced hepatocarcinogenesis by CCl4 cirrhosis. Comparison of the marker enzyme patterns.
Topics: Animals; Carbon Tetrachloride; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Drug Administration Schedule; gamma-Glutamyltransferase; Glucosephosphate Dehydrogenase; Liver Cirrhosis, Experimental; Liver Neoplasms, Experimental; Male; Phenobarbital; Rats; Rats, Inbred F344 | 1992 |
Possible enhancing effect of the immunosuppressive agent, 6-mercaptopurine(6-MP) on focal lesion development in cirrhotic liver induced by carbon tetrachloride but not furfural in F344 rats.
Topics: Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Drug Synergism; Furaldehyde; gamma-Glutamyltransferase; Glutathione Transferase; Liver; Liver Cirrhosis, Experimental; Liver Neoplasms; Male; Mercaptopurine; Phenobarbital; Precancerous Conditions; Rats; Rats, Inbred F344 | 1992 |
Formation of novel non-cyclooxygenase-derived prostanoids (F2-isoprostanes) in carbon tetrachloride hepatotoxicity. An animal model of lipid peroxidation.
Topics: Acetaminophen; Alanine Transaminase; Animals; Carbon Tetrachloride; Indomethacin; Isoniazid; Lipid Peroxides; Male; Phenobarbital; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Thioacetamide | 1992 |
The effect of alcohol-induced hepatomegaly on portal hypertension in cirrhotic rats.
Topics: Animals; Blood Pressure; Carbon Tetrachloride; Collagen; Ethanol; Hemodynamics; Hepatomegaly; Hypertension, Portal; Liver; Liver Cirrhosis, Experimental; Male; Organ Size; Phenobarbital; Rats; Rats, Inbred Strains; Statistics as Topic | 1992 |
Induction of metallothionein synthesis by menadione or carbon tetrachloride is independent of free radical production.
Topics: Animals; Carbon Tetrachloride; Free Radicals; Lipid Peroxidation; Liver; Male; Metallothionein; Mice; Phenobarbital; Vitamin E; Vitamin K | 1992 |
The pituitary in cirrhosis: ultrastructure, growth hormone, and prolactin concentrations.
Topics: Animals; Carbon Tetrachloride; Cell Nucleus; Golgi Apparatus; Growth Hormone; Immunohistochemistry; Liver; Liver Cirrhosis, Experimental; Male; Microscopy, Electron; Phenobarbital; Pituitary Gland; Prolactin; Rats; Rats, Inbred Strains; Receptors, Prolactin; Receptors, Somatotropin | 1992 |
Abnormal lipid composition of microsomes from cirrhotic rat liver--does it contribute to decreased microsomal function?
Topics: Animals; Bile Ducts; Carbon Tetrachloride; Cholesterol; Endoplasmic Reticulum; Fatty Acids; Fluorescence Polarization; Intracellular Membranes; Ligation; Lipid Metabolism; Liver Cirrhosis, Experimental; Male; Microsomes, Liver; Phenobarbital; Phospholipids; Rats; Rats, Inbred Strains | 1992 |
Lethal effects of CCl4 and its metabolism by Mongolian gerbils pretreated with chlordecone, phenobarbital, or mirex.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Dioxide; Carbon Tetrachloride; Chlordecone; Cytochrome P-450 Enzyme System; Gerbillinae; Insecticides; Lethal Dose 50; Lipid Peroxidation; Liver; Male; Mirex; Phenobarbital | 1990 |
Altered hepatic energy status in chlordecone (Kepone)-potentiated CCl4 hepatotoxicity.
Topics: Adenosine Triphosphate; Animals; Ca(2+) Mg(2+)-ATPase; Carbon Tetrachloride; Chlordecone; Energy Metabolism; Insecticides; Lipid Peroxidation; Liver; Male; Mirex; Phenobarbital; Rats; Rats, Inbred Strains | 1990 |
Hepatotoxicity and lethality of halomethanes in Mongolian gerbils pretreated with chlordecone, phenobarbital or mirex.
Topics: Animals; Bromotrichloromethane; Carbon Tetrachloride; Chlordecone; Chloroform; DNA; Dose-Response Relationship, Drug; Gerbillinae; Lethal Dose 50; Liver; Male; Mirex; Phenobarbital; Species Specificity | 1991 |
Studies on the role of liver cytochrome P-450 and oestradiol metabolism in the effects of nutrition and phenobarbital on ovulation rate in the ewe.
Topics: Animal Nutritional Physiological Phenomena; Animals; Carbon Tetrachloride; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Estradiol; Female; Liver; Ovulation; Oxidoreductases, N-Demethylating; Phenobarbital; Sheep; Troleandomycin | 1991 |
In micronodular cirrhosis, hepatocytes retain a normal C-25 hydroxylation capacity toward vitamin D3: a study using the rat carbon tetrachloride-induced cirrhotic model.
Topics: Animals; Calcifediol; Carbon Tetrachloride; Cholecalciferol; Cytochrome P-450 Enzyme System; Hydroxylation; Liver; Liver Cirrhosis, Experimental; Male; Methylcholanthrene; Phenobarbital; Rats; Rats, Inbred Strains | 1991 |
Liver cirrhosis in rats: regeneration and assessment of the role of phenobarbital.
Topics: Animals; Carbon Tetrachloride; Hepatectomy; Liver; Liver Cirrhosis, Experimental; Liver Regeneration; Male; Phenobarbital; Prohibitins; Rats; Rats, Inbred Strains | 1991 |
CCl4 cirrhosis in rats: irreversible histological changes and differentiated functional impairment.
Topics: Animals; Antipyrine; Carbon Tetrachloride; Galactose; Liver; Liver Cirrhosis, Experimental; Male; Phenobarbital; Rats; Rats, Inbred Strains; Urea | 1991 |
Inhibitory and promoting effects of carbon tetrachloride-induced liver cirrhosis on the diethylnitrosamine hepatocarcinogenesis in rats.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Diethylnitrosamine; Liver; Liver Cirrhosis, Experimental; Liver Neoplasms, Experimental; Male; Phenobarbital; Rats; Rats, Inbred F344 | 1991 |
Biokinetics of 99mTc-labelled liver-imaging agents in an animal model of liver cirrhosis.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Liver; Liver Cirrhosis, Experimental; Male; Organotechnetium Compounds; Phenobarbital; Phytic Acid; Radionuclide Imaging; Rats; Rats, Inbred Strains; Technetium Tc 99m Sulfur Colloid | 1991 |
A CCl4/CHCl3 interaction study in isolated hepatocytes: non-induced and phenobarbital-pretreated cells.
Topics: Animals; Carbon Tetrachloride; Cell Survival; Chloroform; Cytochrome P-450 Enzyme System; Drug Synergism; Enzyme Induction; In Vitro Techniques; L-Lactate Dehydrogenase; Liver; Phenobarbital; Potassium; Rats | 1991 |
Influence of enzyme induction and exposure profile on liver injury due to chlorinated hydrocarbon inhalation.
Topics: Administration, Inhalation; Animals; Biotransformation; Butylene Glycols; Carbon Tetrachloride; Chloroform; Dichloroethylenes; Enzyme Induction; Liver; Male; Phenobarbital; Rats; Rats, Inbred Strains; Time Factors | 1990 |
Effect of Melothria maderaspatana on carbon tetrachloride-induced changes in rat hepatic microsomal drug-metabolizing enzyme activity.
Topics: Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Glutathione; In Vitro Techniques; Kinetics; Lipid Peroxidation; Liver; Male; Malondialdehyde; Microsomes, Liver; Mixed Function Oxygenases; Pharmaceutical Preparations; Phenobarbital; Plant Extracts; Rats; Rats, Inbred Strains; Sleep | 1990 |
Inactivation of hepatocyte protein kinase C by carbon tetrachloride: involvement of drug's metabolic activation and prooxidant effect.
Topics: Animals; Antioxidants; Biotransformation; Carbon Tetrachloride; Cells, Cultured; Chromans; Kinetics; Liver; Male; Microsomes, Liver; Phenobarbital; Protein Kinase C; Rats; Rats, Inbred Strains | 1990 |
Effects of oxygen deficiency and calcium omission on carbon tetrachloride hepatotoxicity in isolated perfused livers from phenobarbital-pretreated rats.
Topics: Animals; Calcium; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; In Vitro Techniques; Liver; Liver Diseases; Male; Oxygen; Perfusion; Phenobarbital; Phenylenediamines; Promethazine; Rats; Rats, Inbred Strains | 1990 |
Phenobarbital pretreatment alters the localization of CCl4-induced changes in rat liver microsomal fatty acids.
Topics: Animals; Carbon Tetrachloride; Cytochrome P-450 Enzyme System; Fatty Acids; Lipid Peroxidation; Male; Microsomes, Liver; Phenobarbital; Phospholipids; Rats; Rats, Inbred Strains | 1990 |
Microsomal metabolism of carbon tetrachloride: participation of pyridine nucleotide synergism.
Topics: Animals; Carbon Tetrachloride; In Vitro Techniques; Lipid Peroxidation; Male; Microsomes, Liver; NAD; NADP; Phenobarbital; Pyridines; Rats; Rats, Inbred Strains | 1990 |
Comparative changes in hepatic DNA, RNA, protein, lipid, and glycogen induced by a subtoxic dose of CCl4 in chlordecone, mirex, and phenobarbital pretreated rats.
Topics: Animals; Carbon Tetrachloride; Chlordecone; DNA; Insecticides; Lipids; Liver; Liver Glycogen; Male; Mirex; Phenobarbital; Proteins; Rats; Rats, Inbred Strains; RNA | 1987 |
Stimulation of DNA synthesis in rat and mouse liver by various tumor promoters.
Topics: Adipates; Aflatoxin B1; Aflatoxins; Aldrin; Animals; Benzidines; Biological Availability; Carbon Tetrachloride; Carcinogens; Cell Division; Circadian Rhythm; DDT; Diethylhexyl Phthalate; DNA; DNA Replication; Female; Hexachlorocyclohexane; Isomerism; Liver; Liver Neoplasms; Male; Mice; Phenobarbital; Polychlorinated Dibenzodioxins; Rats; Thioacetamide | 1987 |
In vivo metabolism of CCl4 by rats pretreated with chlordecone, mirex, or phenobarbital.
Topics: Animals; Carbon Dioxide; Carbon Radioisotopes; Carbon Tetrachloride; Chlordecone; Cytochrome P-450 Enzyme System; Drug Synergism; Insecticides; Lipid Peroxides; Liver; Male; Mirex; Phenobarbital; Rats; Rats, Inbred Strains; Transaminases | 1988 |
Effect in the rat of the interaction of dichloromaleic acid and carbon tetrachloride on renal and hepatic function.
Topics: Animals; Blood Urea Nitrogen; Carbon Tetrachloride; Drinking; Female; Kidney; Kidney Function Tests; Liver; Liver Function Tests; Male; Maleates; Methylcholanthrene; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Water Pollutants; Water Pollutants, Chemical | 1989 |
[Effect of phenobarbital on morphological, histochemical and ultrastructural image of rat liver damaged by carbon tetrachloride. I. Histological and histochemical studies].
Topics: Animals; Carbon Tetrachloride; Liver; Male; Phenobarbital; Rats; Rats, Wistar | 1988 |
Hepatic structural correlates of liver fibrosis: a morphometric analysis.
Topics: Animals; Carbon Tetrachloride; Cell Nucleus; Female; Liver; Liver Cirrhosis, Experimental; Mitochondria, Liver; Phenobarbital; Rats; Rats, Inbred WF | 1989 |
Alkylating toxins and the liver plasma membrane calcium pump/calcium atpase.
Topics: Acetaminophen; Animals; Bromobenzenes; Calcium; Calcium-Transporting ATPases; Carbon Tetrachloride; Cell Membrane; Homeostasis; Kinetics; Liver; Male; Methylcholanthrene; Phenobarbital; Rats; Rats, Inbred Strains | 1988 |
Changes in coenzyme Q level in mitochondria of cirrhotic rat liver.
Topics: Animals; Carbon Tetrachloride; Electron Transport Complex IV; Liver Cirrhosis; Mitochondria, Liver; Oxygen Consumption; Phenobarbital; Rats; Rats, Inbred Strains; Ubiquinone | 1985 |
Hepatic mixed function oxidase system and enzymatic glucose metabolism in rats.
Topics: Animals; Carbon Tetrachloride; Cimetidine; Female; Glucokinase; Glucose; Glucose-6-Phosphatase; Hexokinase; Liver; Microsomes, Liver; Mixed Function Oxygenases; Muscles; Phenobarbital; Rats; Rats, Inbred Strains | 1987 |
Activation of cytochrome P-450 heme in vivo.
Topics: Animals; Carbon Radioisotopes; Carbon Tetrachloride; Cytochrome P-450 Enzyme System; Enzyme Activation; Heme; Immunodiffusion; Isoenzymes; Male; Microsomes, Liver; Molecular Weight; Phenobarbital; Rats; Rats, Inbred Strains; Tritium | 1986 |
Evidence for increased membrane permeability of plasmalemmal vesicles from livers of phenobarbital-induced CCl4-intoxicated rats.
Topics: Animals; Calcimycin; Calcium; Carbon Tetrachloride; Cell Membrane; Cell Membrane Permeability; Egtazic Acid; Liver; Male; Octoxynol; Phenobarbital; Polyethylene Glycols; Potassium; Rats; Rats, Inbred Strains | 1986 |
Sodium cholate extraction of rat liver nuclear xenobiotic-metabolizing enzymes.
Topics: Animals; Carbon Tetrachloride; Cell Nucleus; Cholic Acid; Cholic Acids; Cytochrome P-450 Enzyme System; Cytosol; Liver; Male; Methylcholanthrene; NAD(P)H Dehydrogenase (Quinone); NADP; NADPH-Ferrihemoprotein Reductase; Pharmaceutical Preparations; Phenobarbital; Propane; Quinone Reductases; Rats; Rats, Inbred Strains | 1988 |
Potentiating effects of phenobarbitone on the induction of cirrhosis in rats by carbon tetrachloride.
Topics: Animals; Carbon Tetrachloride; Drug Synergism; Female; Liver; Liver Cirrhosis, Experimental; Necrosis; Phenobarbital; Rats | 1988 |
Glycosaminoglycan containing fat-storing cells in hepatic fibrogenesis.
Topics: Animals; Carbon Tetrachloride; Glycosaminoglycans; Lipid Metabolism; Lipids; Liver; Liver Cirrhosis; Male; Microscopy, Electron; Microscopy, Fluorescence; Phenobarbital; Rats; Rats, Inbred F344 | 1988 |
A simple method for assessment of rat cytochrome P-448 isozymes responsible for the mutagenic activation of carcinogenic chemicals.
Topics: Amines; Animals; Biotransformation; Carbon Tetrachloride; Carcinogens; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; Isoenzymes; Methylcholanthrene; Microsomes, Liver; Mutagenicity Tests; Phenobarbital; Rats | 1988 |
Determinants of hepatic function in liver cirrhosis in the rat. Multivariate analysis.
Topics: Animals; Carbon Tetrachloride; Galactose; Hemodynamics; Liver; Liver Cirrhosis, Experimental; Liver Function Tests; Male; Phenobarbital; Rats; Rats, Inbred Strains; Statistics as Topic; Xenobiotics | 1988 |
The ratio of two isozyme groups in microsomal cytochrome P-450 under exogenous influence of carbon tetrachloride and cyclophosphamide.
Topics: Animals; Carbon Tetrachloride; Cyclophosphamide; Cytochrome P-450 Enzyme System; Isoenzymes; Male; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred F344; Rats, Inbred Strains | 1988 |
[Effect of metabolic changes in the liver on the cytotoxic activity of cyclophosphamide in the incisor of rats].
Topics: Animals; Carbon Tetrachloride; Cyclophosphamide; Dentin; Incisor; Liver; Male; Phenobarbital; Rats; Rats, Inbred Strains; Reference Values | 1988 |
Enhancement of dimethylnitrosamine-initiated hepatocarcinogenesis in hamsters by subsequent administration of carbon tetrachloride but not phenobarbital or p,p'-dichlorodiphenyltrichloroethane.
Topics: Animals; Carbon Tetrachloride; Cocarcinogenesis; Cricetinae; DDT; Dimethylnitrosamine; Liver Neoplasms, Experimental; Male; Mesocricetus; Phenobarbital; Species Specificity | 1987 |
Effects of an inducer and an inhibitor of hepatic metabolism on the antitumor action of dimethyltriazenes.
Topics: Animals; Antineoplastic Agents; Biotransformation; Carbon Tetrachloride; Carcinoma; Liver; Lung Neoplasms; Mice; Neoplasm Metastasis; Phenobarbital; Triazenes | 1988 |
Inhibition of CCl4 metabolism by oxygen varies between isoenzymes of cytochrome P-450.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cytochrome P-450 Enzyme System; Isoenzymes; Isoniazid; Male; Microsomes, Liver; Oxygen; Phenobarbital; Rats; Rats, Inbred Strains | 1988 |
Two mechanisms of CCl4-induced fatty liver: lipid peroxidation or covalent binding studied in cultured rat hepatocytes.
Topics: Animals; Binding, Competitive; Carbon Tetrachloride; Cells, Cultured; Fatty Liver; Female; Lipid Peroxidation; Lipoproteins, HDL; Lipoproteins, VLDL; Liver; Malondialdehyde; Phenobarbital; Piperonyl Butoxide; Rats; Rats, Inbred Strains; Vitamin E | 1987 |
Insulin and glucagon production in experimental cirrhosis.
Topics: Animals; Carbon Tetrachloride; Glucagon; In Vitro Techniques; Insulin; Liver Cirrhosis, Experimental; Male; Phenobarbital; Rats; Rats, Inbred Strains | 1987 |
Drug interactions affecting the elimination of doxorubicin in the rat.
Topics: Animals; Bile; Carbon Tetrachloride; Doxorubicin; Drug Interactions; Kinetics; Male; Phenobarbital; Rats; Rats, Inbred Strains; Rifampin; Sulfobromophthalein; Tissue Distribution | 1987 |
Changes in cytochrome P450 molecular species in rat liver in chloroform intoxication.
Topics: Animals; Carbon Tetrachloride; Chloroform; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Liver; Male; Methylcholanthrene; Phenobarbital; Rats; Rats, Inbred Strains | 1986 |
NADPH-dependent and -independent loss of cytochrome P-450 in control and phenobarbital-induced rat hepatic microsomes incubated with carbon tetrachloride.
Topics: Animals; Carbon Tetrachloride; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Male; Microsomes, Liver; NADP; Phenobarbital; Rats; Rats, Inbred Strains | 1986 |
Studies on the mechanism of interaction between methamphetamine and quinine in rats.
Topics: Animals; Carbon Tetrachloride; Drug Interactions; Hydroxylation; Male; Methamphetamine; Phenobarbital; Proadifen; Quinine; Rats; Rats, Inbred Strains; Stereotyped Behavior | 1986 |
A predictable pathophysiological model of porcine hepatic failure.
Topics: Amino Acids; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Disease Models, Animal; Hepatic Artery; Hepatic Encephalopathy; Ligation; Necrosis; Phenobarbital; Swine | 1986 |
[Detection of cells resistant to the cytotoxic action of CCl4 in rat hepatocyte populations following a single exposure to diethylnitrosamine and subsequent injections of phenobarbital].
Topics: Animals; Carbon Tetrachloride; Diethylnitrosamine; Drug Resistance; Histocytochemistry; Liver; Male; Mitochondria, Liver; Phenobarbital; Rats; Succinate Dehydrogenase; Time Factors | 1986 |
Studies on the mechanism of the protective action of 16,16-dimethylPGE2 in carbon tetrachloride induced acute hepatic injury in the rat.
Topics: 16,16-Dimethylprostaglandin E2; Animals; Body Temperature; Breath Tests; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cytochrome P-450 Enzyme System; Lipid Metabolism; Liver; Male; Phenobarbital; Prostaglandins E, Synthetic; Rats; Rats, Inbred Strains | 1986 |
Correlation between the metabolism of hexobarbital and aminopyrine in vivo in rats.
Topics: Administration, Oral; Aminopyrine; Animals; Aroclors; Carbon Tetrachloride; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Induction; Hexobarbital; Isoenzymes; Liver; Male; Metabolic Clearance Rate; Methylcholanthrene; Phenobarbital; Rats; Rats, Inbred Strains | 1986 |
Influence of the duration and the delay of administration of phenobarbital on its modulating effect on rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Carcinogens; Drug Administration Schedule; Liver Neoplasms; Liver Neoplasms, Experimental; Phenobarbital; Rats | 1987 |
Influence of pyrazolones on hepatic glutathione in rats.
Topics: 1-Propanol; Acetaminophen; Aminopyrine; Animals; Antipyrine; Carbon Tetrachloride; Cobalt; Female; Glutathione; Liver; Phenobarbital; Propanols; Pyrazoles; Rats; Rats, Inbred Strains; Thioacetamide | 1985 |
Enhanced metabolism of volatile hydrocarbons in rat liver following food deprivation, restricted carbohydrate intake, and administration of ethanol, phenobarbital, polychlorinated biphenyl and 3-methylcholanthrene: a comparative study.
Topics: Animals; Carbon Tetrachloride; Cytochrome P-450 Enzyme System; Dietary Carbohydrates; Ethanol; Food Deprivation; Hydrocarbons; Liver; Male; Methylcholanthrene; Phenobarbital; Polychlorinated Biphenyls; Proteins; Rats; Rats, Inbred Strains; Volatilization | 1985 |
[Detection of cells resistant to the cytotoxic action of CCl4 in the hepatocyte populations of rats following a single exposure to 4-dimethylaminoazobenzene combined with subsequent injections of the tumor promoter phenobarbital].
Topics: Animals; Carbon Tetrachloride; Carcinogens; Cell Separation; Drug Resistance; Histocytochemistry; Liver; Male; p-Dimethylaminoazobenzene; Phenobarbital; Rats; Succinate Dehydrogenase; Time Factors | 1985 |
Effect of pretreatment with cimetidine or phenobarbital on lipoperoxidation in carbon tetrachloride- and trichloroethylene-dosed rats.
Topics: Alkanes; Animals; Carbon Tetrachloride; Cimetidine; Dose-Response Relationship, Drug; In Vitro Techniques; Lipid Peroxides; Liver; Male; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Thiobarbiturates; Trichloroethylene | 1986 |
[A comparative study of free amino acid levels in the serum and cerebral cortex in hepatic failure rats].
Topics: Acute Disease; Amino Acids; Ammonia; Animals; Blood-Brain Barrier; Carbon Tetrachloride; Cerebral Cortex; Chemical and Drug Induced Liver Injury; Chronic Disease; Hepatic Encephalopathy; Male; Phenobarbital; Rats; Rats, Inbred Strains | 1986 |
Nucleolar changes during the first steps of experimental hepatocarcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Cell Nucleolus; Cell Transformation, Neoplastic; Cocarcinogenesis; Diethylnitrosamine; Hepatectomy; Histocytochemistry; Liver; Liver Neoplasms; Male; Phenobarbital; Precancerous Conditions; Rats; Rats, Inbred Strains | 1985 |
Heteroassociation of O- and N-isopropyl derivatives of barbital and phenobarbital with 9-ethyladenine.
Topics: Adenine; Barbital; Barbiturates; Carbon Tetrachloride; Chemical Phenomena; Chemistry; Computers; Mephobarbital; Phenobarbital; Spectrophotometry, Infrared; Uracil | 1985 |
Effects of phenobarbital, phorone and carbon tetrachloride pretreatment on the biliary excretion of acetaminophen in rats.
Topics: Acetaminophen; Animals; Bile; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Glucuronates; Glutathione; Ketones; Male; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Sulfates | 1985 |
Comparison of the requirements for hepatic injury with halothane and enflurane in rats.
Topics: Anesthesia, Inhalation; Animals; Biotransformation; Body Temperature; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Enflurane; Fluorides; Halothane; Hot Temperature; Hypoxia; Liver; Male; Models, Biological; Oxygen; Phenobarbital; Rats; Rats, Inbred Strains; Time Factors; Trifluoroacetic Acid | 1985 |
Alteration of hepatic glutathione S-transferases and release into serum after treatment with bromobenzene, carbon tetrachloride, or N-nitrosodimethylamine.
Topics: Animals; Bromobenzenes; Carbon Tetrachloride; Cytochrome P-450 Enzyme System; Cytosol; Dimethylnitrosamine; Ethanol; Glutathione Transferase; Liver; Male; Phenobarbital; Rats; Rats, Inbred Strains | 1985 |
The role of iron in the paracetamol- and CCl4-induced lipid peroxidation and hepatotoxicity.
Topics: Acetaminophen; Animals; Breath Tests; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Deferoxamine; Enzyme Induction; Ethane; Iron; Lipid Peroxides; Male; Mice; Phenobarbital; Rats; Rats, Inbred Strains | 1985 |
Endogenous hepatic growth-modulating factors and effects of a choline-devoid diet and of phenobarbital on hepatocarcinogenesis in the rat.
Topics: Animals; Carbon Tetrachloride; Choline; Diet; DNA; Ethionine; Growth Substances; Liver; Liver Neoplasms, Experimental; Male; Phenobarbital; Prohibitins; Rats; Rats, Inbred Strains; Thymidine | 1985 |
[Biochemical change in rat serum following combined application of liver-enlarging and hepatotoxic drugs].
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Drug Synergism; Enzyme Induction; Hexachlorocyclohexane; L-Lactate Dehydrogenase; Liver; Microsomes, Liver; Phenobarbital; Praseodymium; Rats; Succinate Dehydrogenase | 1970 |
Microsomal phospholipids and drug action--quantitative biochemical and electron microscopic studies.
Topics: Animals; Carbon Tetrachloride; Choline; Coumarins; Dactinomycin; Endoplasmic Reticulum; Ethanol; Ethionine; Female; Glucose-6-Phosphatase; Hexobarbital; Histocytochemistry; In Vitro Techniques; Male; Methylcholanthrene; Microscopy, Electron; Microsomes, Liver; Nitrosamines; Phenobarbital; Phosphatidylethanolamines; Phospholipases; Phospholipids; Rats | 1972 |
Hepatic amidopyrine N-demethylase activity in the calf.
Topics: Aminopyrine; Animals; Arginase; Aspartate Aminotransferases; Bilirubin; Carbon Tetrachloride; Cattle; Centrifugation; Deoxyribonucleases; Female; Halothane; Liver; Naphthalenes; Oxidoreductases; Phenobarbital; Staining and Labeling; Time Factors | 1972 |
Long-term effects of carbon tetrachloride and sodium phenobarbitone administration on rat serum proteins.
Topics: Alpha-Globulins; Animals; Blood Proteins; Body Weight; Carbon Tetrachloride; gamma-Globulins; Immunodiffusion; Liver; Liver Cirrhosis; Male; Phenobarbital; Rats; Serum Albumin; Time Factors; Transferrin | 1973 |
The biotransformation of 8-ethylthio-6-thiotheophylline sodium in vivo.
Topics: Amines; Animals; Carbon Tetrachloride; Chromatography, Thin Layer; Dactinomycin; Depression, Chemical; Hypnotics and Sedatives; Male; Methylcholanthrene; Oils; Phenobarbital; Proadifen; Rats; Sleep; Stimulation, Chemical; Theophylline; Time Factors | 1968 |
Studies on the irreversible binding of 14 C-CCl 4 to microsomal lipids in rats under varying experimental conditions.
Topics: Adrenal Glands; Adrenalectomy; Aminopyrine; Animals; Carbon Isotopes; Carbon Tetrachloride; Castration; Centrifugation, Density Gradient; Edetic Acid; Ethylamines; Gonads; Hydroxylation; Lipid Metabolism; Liver; Male; Malonates; Microsomes, Liver; Niacinamide; Phenobarbital; Phenols; Proadifen; Rats; Sleep; Sucrose | 1972 |
Effects of carbon tetrachloride and phenobarbital on plasma membranes. Enzymes and phospholipid transfer.
Topics: Adenosine Triphosphatases; Animals; Carbon Tetrachloride; Cell Membrane; Centrifugation; Liver; Microscopy, Electron; Microsomes, Liver; Mitochondria, Liver; Monoamine Oxidase; N-Glycosyl Hydrolases; Oxidoreductases; Phenobarbital; Phospholipids; Rats; Succinate Dehydrogenase | 1974 |
Proceedings: Kinetics of the binding of carbon monoxide and oxygen to microsomal cytochrome P450 and the influence of substrates.
Topics: Animals; Binding Sites; Carbon Monoxide; Carbon Tetrachloride; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Halothane; Hexobarbital; In Vitro Techniques; Kinetics; Ligands; Metyrapone; Microsomes, Liver; Oxygen Consumption; Phenobarbital; Photolysis; Rats; Spectrophotometry; Temperature; Tetrachloroethylene; Trichloroethylene | 1974 |
Antagonistic effect of foreign compounds on microsomal enzymes of the liver of the rat.
Topics: Acetates; Amides; Animals; Carbon Tetrachloride; Coumarins; Drug Antagonism; Enzymes; Ethionine; Female; Hexobarbital; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Phosphoric Monoester Hydrolases; Rats; Toluene | 1970 |
[Effect of increasing doses of carbon tetrachloride on rat microsomal enzymes with and without phenobarbital pretreatment].
Topics: Aniline Compounds; Animals; Carbon Tetrachloride; Cholinesterases; Cytochromes; Glucose-6-Phosphatase; Male; Microsomes, Liver; Oxidoreductases; Phenobarbital; Rats | 1970 |
[Effect of carbon tetrachloride on endoplasmic enzymes in rat liver].
Topics: Aminopyrine; Aniline Compounds; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cholinesterases; Cytochromes; Endoplasmic Reticulum; Formaldehyde; Glucose-6-Phosphatase; Hexobarbital; Male; Membranes; Microsomes, Liver; Oxidation-Reduction; Oxidoreductases; Phenobarbital; Protein Binding; Rabbits; Rats; Spectrophotometry | 1971 |
The effects of various drugs and toxic agents on bile flow rate and composition in the rat.
Topics: Adenosine Triphosphate; Animals; Bile; Bile Acids and Salts; Bilirubin; Body Temperature; Body Weight; Carbon Tetrachloride; Dinitrophenols; Ethionine; Female; Hydrogen-Ion Concentration; Liver; Male; Malonates; NAD; Nitrosamines; Organ Size; Phenobarbital; Rats; Succinates; Time Factors | 1971 |
Relation between drug-metabolizing activity and phospholipids in hepatic microsomes. I. Effects of phenobarbital, carbon tetrachloride, and actinomycin D.
Topics: Animals; Carbon Tetrachloride; Chromatography, Thin Layer; Coumarins; Dactinomycin; Enzyme Induction; Female; Glucose-6-Phosphatase; Lysophosphatidylcholines; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Phosphatidylethanolamines; Phospholipids; Proteins; Rats; Stimulation, Chemical | 1972 |
Carbon tetrachloride activation in liver microsomes from rats induced with 3-methylcholantrene.
Topics: Animals; Carbon Isotopes; Carbon Tetrachloride; Cytochrome P-450 Enzyme System; Enzyme Induction; Glucose-6-Phosphatase; In Vitro Techniques; Lipid Metabolism; Male; Methylcholanthrene; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Rats | 1973 |
Effects of drugs or hepatotoxins on the relation between drug-metabolizing activity and phospholipids in hepatic microsomes during choline deficiency.
Topics: Animals; Carbon Tetrachloride; Choline; Coumarins; Diet; Female; Germ-Free Life; Glucose-6-Phosphatase; Guanine Nucleotides; Inosine; Lysophosphatidylcholines; Male; Methyltransferases; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipids; Phosphoric Monoester Hydrolases; Proteins; Rats; Time Factors | 1973 |
[Influence of diethylnitrosamine, carbon tetrachloride, butter yellow and cyclophosphamide on amino acid incorporation into fractions of liver homogenates after metabolic activation in vitro. Possibilities for the detection of hepatotoxic effects].
Topics: Amino Acids; Aniline Compounds; Animals; Carbon Isotopes; Carbon Tetrachloride; Cyclophosphamide; Leucine; Liver; Male; Microsomes; Models, Biological; NADP; Nitrosamines; p-Dimethylaminoazobenzene; Phenobarbital; Protein Biosynthesis; Rats | 1969 |
Significance of mixed oxygenases and nitroreductase in drug metabolism.
Topics: Animals; Anthelmintics; Carbon Monoxide; Carbon Tetrachloride; Chemical Phenomena; Chemistry; Cytochromes; Haplorhini; Imidazoles; Microsomes, Liver; NADP; Nitrogen; Oxidation-Reduction; Oxidoreductases; Oxygenases; Pharmaceutical Preparations; Phenobarbital | 1969 |
A comparison of the effects of halothane and CCl 4 on the hepatic drug metabolizing system.
Topics: Aniline Compounds; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cytochromes; Dealkylation; Halothane; Liver; Male; Microscopy, Electron; Microsomes, Liver; Mixed Function Oxygenases; Morphinans; NADP; Organ Size; Oxidoreductases; Phenobarbital; Rats | 1971 |
Drug metabolism in man: past, present, and future.
Topics: Aerobiosis; Alkylating Agents; Allyl Compounds; Animals; Autoradiography; Bromine; Carbon Isotopes; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemistry; Chlorine; Chromatography, Paper; Ethers, Cyclic; Glutathione; Hydrocarbons, Halogenated; Iodine; Liver; Male; Mice; Microsomes, Liver; Models, Biological; NADP; Necrosis; Phenobarbital; Rats; Sheep; Sulfur Isotopes | 1971 |
[Extraction of cytochrome P450 after incubation with CCl 4 in an NADPH-regenerating system and partial transformation into cytochrome P420].
Topics: Animals; Carbon Tetrachloride; Cytochromes; Drug Interactions; Male; Microsomes; NADP; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred Strains | 1971 |
A comparison of mouse and rat liver enzymes and their response to treatment with various compounds.
Topics: Aminopyrine; Animals; Carbon Tetrachloride; Chlorpromazine; Clofibrate; Cytochromes; DDT; Germ-Free Life; Glucose-6-Phosphatase; Glucosephosphate Dehydrogenase; Griseofulvin; L-Lactate Dehydrogenase; Liver; Mice; NAD; NADP; Organ Size; Oxidoreductases; Phenobarbital; Phosphogluconate Dehydrogenase; Rats; Species Specificity | 1972 |
Fluroxene toxicity in mice.
Topics: Animals; Biotransformation; Carbon Tetrachloride; Drug Interactions; Enzyme Induction; Ethanol; Ethers; Fluorine; Halothane; Male; Mice; Mice, Inbred Strains; Phenobarbital; Time Factors | 1972 |
Biochemical effects of 1,1-dichloroethylene in rats: comparison with carbon tetrachloride and 1,2-dichloroethylene.
Topics: Administration, Oral; Alanine Transaminase; Alkaline Phosphatase; Animals; Carbon Tetrachloride; Chlorine; Ethylenes; Glucose-6-Phosphatase; Hydrocarbons, Halogenated; Lethal Dose 50; Liver; Phenobarbital; Rats; Structure-Activity Relationship; Time Factors; Tyrosine Transaminase | 1972 |
Studies on an unusual N-dealkylation reaction. II. Characteristics of the enzyme system and a proposed pathway for the reaction.
Topics: Anaerobiosis; Animals; Butanes; Carbon Tetrachloride; Cytoplasm; Decarboxylation; Histamine H1 Antagonists; Hydroxylation; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; NAD; NADP; Oxidation-Reduction; Oxides; Oxygen; Phenobarbital; Piperazines; Rats; Subcellular Fractions | 1973 |
The effects of phenobarbital and carbon tetrachloride on the rate of decline of body burdens of hexachlorobenzene in the rat.
Topics: Aminopyrine N-Demethylase; Aniline Compounds; Animals; Body Burden; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chlorobenzenes; Cholinesterases; Diet; Drug Synergism; Enzyme Induction; Female; Kinetics; Liver; Male; Microsomes, Liver; Mixed Function Oxygenases; Organ Size; Pesticide Residues; Phenobarbital; Rats; Time Factors | 1974 |
The influence of age, phenobarbital and carbontetrachloride on the bromsulphthaleine binding to cytosol of various organs and on the bromsulphthaleine elimination from blood.
Topics: Age Factors; Animals; Binding Sites; Brain; Carbon Tetrachloride; Cytosol; Kidney; Liver; Muscles; Phenobarbital; Rats; Sulfobromophthalein | 1974 |
Hepatic zinc concentrations in experimental cirrhosis induced with carbon tetrachloride and phenobarbitone.
Topics: Animals; Carbon Tetrachloride; Liver; Liver Cirrhosis, Experimental; Male; Phenobarbital; Rats; Spectrophotometry, Atomic; Time Factors; Zinc | 1974 |
[The induction of liver cirrhosis in rats by simultaneous administration of carbon tetrachloride and phenobarbitone (author's transl)].
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Drug Synergism; Liver Cirrhosis; Male; Phenobarbital; Rats; Time Factors | 1973 |
Effect of the production of experimental cirrhosis in rats on serum aminotransferase levels.
Topics: Alanine; Animals; Aspartic Acid; Carbon Tetrachloride; Drug Synergism; Kinetics; Liver Cirrhosis; Phenobarbital; Rats; Transaminases | 1972 |
Effect of experimental hepatic injury on the clearance of phenobarbital and paraldehyde.
Topics: Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bilirubin; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Common Bile Duct; Creatinine; False Positive Reactions; Kidney; L-Lactate Dehydrogenase; Ligation; Liver; Male; Nephrectomy; Paraldehyde; Phenobarbital; Rats; Time Factors | 1973 |
Potentiation of CCl4-induced hepatotoxicity in the dog by chronic exposure to phenobarbital.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Dogs; Drug Synergism; Fluorometry; In Vitro Techniques; Liver; Microsomes, Liver; Peroxides; Phenobarbital; Time Factors; Triglycerides | 1973 |
Role of cytochrome P-450 in carbon tetrachloride activation and CCl 4-induced necrosis. Effect of inhibitors of heme synthesis. I. 3-Amino-1,2,4 triazole.
Topics: Animals; Carbon Isotopes; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Activation; Female; Heme; Lipid Metabolism; Liver; Male; Microsomes, Liver; Necrosis; Organ Size; Phenobarbital; Triazoles | 1973 |
Phenobarbital and organic solvent toxicity.
Topics: Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chloroform; Drug Synergism; Environmental Exposure; Ethane; Hydrocarbons, Chlorinated; Hydrocarbons, Halogenated; Injections, Intraperitoneal; Liver; Male; Methane; Methyl Chloride; Phenobarbital; Rats; Solvents; Tetrachloroethylene; Trichloroethylene | 1973 |
The effect of carbon disulphide used in combination with carbon tetrachloride on the toxicity of the latter drug for sheep.
Topics: Aminopyrine; Animals; Biopsy; Carbon Disulfide; Carbon Radioisotopes; Carbon Tetrachloride; DDT; Diet; Drug Combinations; Fasciola hepatica; Liver; Male; Microsomes, Liver; Phenobarbital; Proadifen; Sheep | 1973 |
Ethane evolution: a new index of lipid peroxidation.
Topics: Aldehydes; Animals; Antioxidants; Brain; Carbon Tetrachloride; Depression, Chemical; Ethane; In Vitro Techniques; Lipid Metabolism; Liver; Malonates; Mice; Oxidation-Reduction; Phenobarbital; Stimulation, Chemical; Vitamin E | 1974 |
Alterations in the rate of phospholipid exchange between cell membranes.
Topics: Animals; Carbon Tetrachloride; Cations, Divalent; Cell Membrane; Ethanol; Liver; Male; Microsomes, Liver; Mitochondria, Liver; Phenobarbital; Phospholipids; Phosphorus Radioisotopes; Protein Denaturation; Rats | 1974 |
Massive liver cell necrosis induced in the pig with carbon tetrachloride.
Topics: Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Synergism; Exchange Transfusion, Whole Blood; Female; Hepatic Artery; Hepatic Encephalopathy; Injections, Intra-Arterial; Injections, Intravenous; Liver; Liver Diseases; Male; Necrosis; Phenobarbital; Portal Vein; Swine | 1974 |
The effect of experimental local inflammation on the action of barbiturates in rat.
Topics: Animals; Barbiturates; Carbon Tetrachloride; Carrageenan; Charcoal; Chlordan; Enzyme Induction; Gossypium; Hexobarbital; Inflammation; Injections, Subcutaneous; Male; Microsomes, Liver; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Sleep; Time Factors; Yeasts | 1972 |
The effect of benzpyrene, phenobarbital, and carbon tetrachloride on subcellular metal distribution and microsomal enzyme activity.
Topics: Animals; Benzopyrenes; Carbon Tetrachloride; Chromium; Copper; Liver; Lung; Manganese; Metals; Microsomes; Microsomes, Liver; Nickel; Nitrogen; Phenobarbital; Rats; Subcellular Fractions; Time Factors; Zinc | 1972 |
Effects of microsomal enzyme inducers on animals poisoned with hepatotoxins.
Topics: Alanine Transaminase; Animals; Barbiturates; Blood Proteins; Body Weight; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Enzyme Induction; Hydrocarbons, Halogenated; Intubation, Gastrointestinal; Male; Methylcellulose; Mice; Mice, Inbred Strains; Microsomes, Liver; Phenobarbital; Phosphorus; Rats; Rats, Inbred Strains; Sulfobromophthalein; Time Factors | 1972 |
The effect of diet and drugs on hepatic microsomal aminopyrine N-demethylase activity in vitro and susceptibility to carbon tetrachloride in sheep.
Topics: Aminopyrine; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; DDT; Diet; Dietary Proteins; Food Deprivation; Freezing; Liver; Male; Microsomes, Liver; Oxidoreductases; Phenobarbital; Sheep; Sheep Diseases; Water Deprivation | 1972 |
Porta-pulmonary venous anastomoses in experimental cirrhosis of the liver in rats.
Topics: Animals; Arteries; Barium Sulfate; Carbon Tetrachloride; Coronary Vessels; Esophagus; Hypoxia; Liver Cirrhosis; Liver Cirrhosis, Experimental; Male; Mediastinum; Oxygen; Phenobarbital; Pleura; Portal Vein; Pulmonary Alveoli; Pulmonary Veins; Radiography; Rats; Stomach | 1972 |
Labeling in vivo of rat liver proteins by tritium-labeled dimethylnitrosamine. Effect of prior treatment with 3-methylcholanthrene, phenobarbitone, dimethylformamide, diethyl-formamide, aminoacetonitrile, ethionine and carbon tetrachloride.
Topics: Amides; Animals; Carbon Tetrachloride; Carcinogens; Dimethylformamide; Endoplasmic Reticulum; Ethionine; Female; Formamides; Liver; Liver Neoplasms; Male; Methylcholanthrene; Neoplasms, Experimental; Nitriles; Nitrosamines; Phenobarbital; Protein Biosynthesis; Rats; Tritium | 1971 |
The effect of microsomal enzyme stimulants and depressants on amphetamine aggregation toxicity in mice.
Topics: Amphetamine; Animals; Benzopyrenes; Carbon Tetrachloride; Chlordan; Enzyme Repression; Male; Methylcholanthrene; Mice; Microsomes; Phenobarbital; Proadifen | 1969 |
Contrastic effects of ethionine and carbontetrachloride on ascorbic acid metabolism and on the activity of microsomal drug-metabolizing enzymes in rats.
Topics: Analysis of Variance; Animals; Ascorbic Acid; Carbon Tetrachloride; Chlorobutanol; Ethionine; Female; Injections, Intraperitoneal; Kidney; Liver; Meprobamate; Methylcholanthrene; Microsomes; Phenobarbital; Rats; Zoxazolamine | 1967 |
The use of phenobarbital and carbon tetrachloride to examine liver phospholipid exchange in intact rats.
Topics: Adenine Nucleotides; Animals; Carbon Tetrachloride; Female; Liver; Microsomes, Liver; Mitochondria, Liver; Organ Size; Phenobarbital; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipids; Phosphorus Isotopes; Rats | 1969 |
Instant cirrhosis. An improved method for producing cirrhosis of the liver in rats by simultaneous administration of carbon tetrachloride and phenobarbitone.
Topics: Animals; Ascites; Carbon Tetrachloride; Gases; Hypertension, Portal; Liver Cirrhosis, Experimental; Male; Methods; Phenobarbital; Rats; Splenomegaly; Testicular Diseases; Time Factors | 1969 |
A rapid method for producing cirrhosis of the liver in rats and its effect on microsomal enzyme activity.
Topics: Animals; Carbon Tetrachloride; Liver Cirrhosis, Experimental; Methods; Microsomes, Liver; Phenobarbital; Rats | 1970 |
The effect of protein deficiency and microsomal enzyme induction by DDT and phenobarbitone on the acute toxicity of chloroform and a pyrrolizidine alkaloid, retrorsine.
Topics: Alkaloids; Animals; Carbon Tetrachloride; Chloroform; DDT; Enzyme Induction; Heterocyclic Compounds; Liver; Male; Microsomes; Phenobarbital; Protein Deficiency; Rats | 1970 |
The effect of SKF 525A on the distribution of carbon tetrachloride in rats.
Topics: Adipose Tissue; Administration, Oral; Animals; Brain Chemistry; Carbon Isotopes; Carbon Tetrachloride; Injections, Intraperitoneal; Injections, Subcutaneous; Intestinal Absorption; Liver; Male; Muscles; Phenobarbital; Proadifen; Rats; Solubility; Time Factors; Toluene | 1970 |
Effects of phenobarbital pretreatment on the hepatotoxicity of carbon tetrachloride.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Drug Synergism; Injections, Intraperitoneal; Liver; Liver Diseases; Male; Necrosis; Phenobarbital; Rats; Sleep; Time Factors | 1970 |
Toxicity of carbon tetrachloride and other fasciocidal drugs in sheep and chickens.
Topics: Administration, Oral; Alcohol Oxidoreductases; Animals; Anthelmintics; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chickens; DDT; Fascioliasis; Female; Glutamate Dehydrogenase; Hydrocarbons, Halogenated; Injections, Intraperitoneal; Kidney; Lethal Dose 50; Liver; Male; Muscles; Nitriles; Nitrophenols; Ornithine Carbamoyltransferase; Peritonitis; Phenobarbital; Sheep; Sorbitol | 1971 |
Mechanism of p-nitrobenzoate reduction in liver: the possible role oc cytochrome P-450 in liver microsomes.
Topics: Animals; Benzoates; Carbon Tetrachloride; Cytochromes; Liver; Male; Mice; Microsomes; Nitrobenzenes; Oxidoreductases; Phenobarbital; Rabbits; Rats | 1968 |
Toxicity of carbon tetrachloride.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Liver; Phenobarbital; Phenylbutazone; Rats | 1969 |
Induced susceptibility of sheep to carbon tetrachloride intoxication.
Topics: Animals; Bilirubin; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Liver; Male; Phenobarbital; Sheep; Sheep Diseases | 1967 |
Potentiation of carbon tetrachloride hepatotoxicity by beta-phenethyl alcohol.
Topics: Acetaminophen; Alanine Transaminase; Alcohols; Animals; Carbon Tetrachloride; Drug Synergism; Ethanol; Liver; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Phenylethyl Alcohol; Rats; Rats, Inbred Strains | 1984 |
Carbon tetrachloride activation by highly purified liver mitochondrial preparations.
Topics: Animals; Biotransformation; Carbon Tetrachloride; Cyanides; Glucose-6-Phosphatase; In Vitro Techniques; Male; Microscopy, Electron; Microsomes, Liver; Mitochondria, Liver; NADP; Phenobarbital; Rats; Rats, Inbred Strains | 1984 |
Functional and biochemical correlates of chlordecone exposure and its enhancement of CCl4 hepatotoxicity.
Topics: Animals; Bile; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chlordecone; Drug Interactions; Enzyme Induction; Glutathione; Insecticides; Kidney; Lipid Metabolism; Lipid Peroxides; Liver; Liver Function Tests; Male; Mixed Function Oxygenases; Pentobarbital; Phenobarbital; Protein Binding; Rats; Sleep; Time Factors | 1980 |
Potentiation of CCl4 lethality by chlordecone.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chlordecone; Drug Synergism; Insecticides; Lethal Dose 50; Liver; Male; Mixed Function Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains | 1982 |
Acute hepatotoxicity and lethality of CCl4 in chlordecone-pretreated rats.
Topics: Acute Disease; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chlordecone; Insecticides; Isocitrate Dehydrogenase; Lethal Dose 50; Liver; Male; Mirex; Phenobarbital; Rats; Rats, Inbred Strains | 1983 |
Destruction of hepatic mixed-function oxygenase parameters by CCl4 in rats following acute treatment with chlordecone, Mirex, and phenobarbital.
Topics: Alanine Transaminase; Aminopyrine N-Demethylase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chlordecone; Cytochrome P-450 Enzyme System; Drug Synergism; Glucose-6-Phosphatase; Insecticides; Isocitrate Dehydrogenase; Male; Microsomes, Liver; Mirex; Mixed Function Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains | 1983 |
CCl4-induced alterations in Ca++ homeostasis in chlordecone and phenobarbital pretreated animals.
Topics: Animals; Calcium; Carbon Tetrachloride; Chlordecone; Cytochrome P-450 Enzyme System; Insecticides; Liver; Male; Microsomes, Liver; Mitochondria, Liver; Phenobarbital; Rats; Rats, Inbred Strains | 1984 |
Perturbation of calcium homeostasis by CCl4 in rats pretreated with chlordecone and phenobarbital.
Topics: Animals; Calcium; Carbon Tetrachloride; Chlordecone; Cytochrome P-450 Enzyme System; Cytosol; Diet; Drug Synergism; Homeostasis; Insecticides; Male; Microsomes, Liver; Mitochondria, Liver; Phenobarbital; Rats; Rats, Inbred Strains | 1984 |
Inhibition of liver-microsome calcium pump by in vivo administration of CCl4, CHCl3 and 1,1-dichloroethylene (vinylidene chloride).
Topics: Animals; Biological Transport, Active; Calcium; Carbon Tetrachloride; Chloroform; Dichloroethylenes; Glucose-6-Phosphatase; Hydrocarbons, Chlorinated; Lipid Peroxides; Male; Microsomes, Liver; Phenobarbital; Rats | 1980 |
Comparative studies on the hepatotoxic actions of chloroform and related halogenomethanes in normal and phenobarbital-pretreated animals.
Topics: Animals; Carbon Tetrachloride; Chloroform; Ditiocarb; Drug Synergism; Hydrocarbons, Halogenated; In Vitro Techniques; Lipid Peroxides; Liver; Male; Methane; Mice; Microsomes, Liver; Phenobarbital; Rats; Transaminases; Triglycerides | 1980 |
The damage of the hepatic mixed functional oxygenase system by CCl4: significance of incorporation of 14CCl4 metabolites in vivo.
Topics: Animals; Carbon Radioisotopes; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cholecalciferol; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Cytochromes; Cytochromes b5; Female; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred Strains | 1982 |
Induction of hyperplastic liver nodules in hepatectomized rats treated with 3'-methyl-4-dimethylaminoazobenzene, benzo[a]pyrene or phenobarbital before or after exposure to N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Animals; Benzo(a)pyrene; Benzopyrenes; Carbon Tetrachloride; Hepatectomy; Hyperplasia; Liver; Liver Neoplasms; Male; Methyldimethylaminoazobenzene; p-Dimethylaminoazobenzene; Phenobarbital; Rats; Rats, Inbred F344 | 1982 |
Carbon tetrachloride-induced hepatic fibrosis and cirrhosis in the developing rat: an experimental model of cirrhosis in childhood.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Collagen; Disease Models, Animal; Hydroxyproline; Liver; Liver Cirrhosis, Experimental; Male; Phenobarbital; Procollagen-Proline Dioxygenase; Rats; Rats, Inbred Strains; Time Factors | 1983 |
Ethanol-inducible cytochrome P-450 is more susceptible to in vitro carbon tetrachloride-mediated destruction than phenobarbital-inducible and beta-naphthoflavone-inducible cytochromes P-450.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Benzoflavones; beta-Naphthoflavone; Biotransformation; Carbon Tetrachloride; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Ethanol; Free Radicals; Male; Microsomes, Liver; NADP; Nitroanisole O-Demethylase; Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains | 1984 |
A morphometric analysis of the hypertrophy of experimental liver cirrhosis.
Topics: Animals; Bile Ducts, Intrahepatic; Carbon Tetrachloride; Connective Tissue; Hepatomegaly; Hypertrophy; Kupffer Cells; Liver; Liver Cirrhosis, Experimental; Male; Microscopy, Electron; Phenobarbital; Rats | 1983 |
Effects of phenobarbital, GSH-depletors, CCl4 and ethanol on the biliary efflux of glutathione in rats.
Topics: Acetaminophen; Animals; Bile; Carbon Tetrachloride; Dichloroethylenes; Ethanol; Glutathione; Ketones; Male; Phenobarbital; Rats; Rats, Inbred Strains | 1983 |
Activation and inactivation of cancer chemotherapeutic agents by rat hepatocytes cocultured with human tumor cell lines.
Topics: Animals; Antineoplastic Agents; Carbon Tetrachloride; Cell Survival; Colony-Forming Units Assay; Cyclophosphamide; Freezing; Humans; Liver; Lung Neoplasms; Phenobarbital; Rats; Rhabdomyosarcoma; Tissue Preservation; Tumor Stem Cell Assay | 1984 |
Different effects of carbon tetrachloride toxicity and cirrhosis on substrate binding to rat hepatic microsomal cytochrome P-450.
Topics: Animals; Carbon Tetrachloride; Cytochrome P-450 Enzyme System; Ethylmorphine; Liver Cirrhosis; Male; Metyrapone; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains | 1984 |
Differences in the response of hepatic and intestinal drug metabolizing enzymes in rats following carbon tetrachloride and/or phenobarbital treatment.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Carbon Tetrachloride; Endoplasmic Reticulum; Epoxide Hydrolases; Glucuronosyltransferase; Injections, Intraperitoneal; Injections, Subcutaneous; Intestinal Mucosa; Intestine, Small; Male; Microsomes, Liver; Phenobarbital; Phospholipids; Proteins; Rats | 1980 |
Altered pharmacodynamics of 1-(2-tetrahydrofuryl)-5-fluorouracil by pretreatment of rats with phenobarbital, indomethacin, diclofenac sodium and carbon tetrachloride.
Topics: Animals; Carbon Tetrachloride; Diclofenac; Female; Fluorouracil; Indomethacin; Microsomes, Liver; Phenobarbital; Phenylacetates; Rats; Tegafur; Time Factors | 1980 |
Development of tolerance to the pulmonary toxin, 4-ipomeanol.
Topics: Animals; Carbon Tetrachloride; Drug Resistance; Drug Tolerance; Enzyme Induction; Furans; Lung; Male; Mice; Naphthalenes; Phenobarbital; Proadifen; Rabbits; Rats; Terpenes; Thiourea; Time Factors; Toxins, Biological | 1981 |
Phosgene: a possible role in the potentiation of carbon tetrachloride hepatotoxicity by 2-propanol.
Topics: 1-Propanol; Animals; Carbon Dioxide; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Chloroform; Male; Microsomes, Liver; Phenobarbital; Phosgene; Rats | 1981 |
Modification of the hepatotoxicity of carbon tetrachloride and chloroform in goats by pre-treatment with dieldrin and phenobarbitone.
Topics: Animals; Carbon Tetrachloride; Chloroform; Dieldrin; Enzyme Induction; Goats; Liver; Male; Microsomes, Liver; Phenobarbital | 1982 |
Dietary cholesterol-induced changes of xenobiotic metabolism in liver. II. Effects of phenobarbitone and carbon tetrachloride on activities of drug-metabolizing enzymes.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Benzopyrene Hydroxylase; Carbon Tetrachloride; Cholesterol, Dietary; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Enzyme Induction; Epoxide Hydrolases; Glucuronosyltransferase; Glutathione Transferase; Liver; Male; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Oxidoreductases; Oxygenases; Phenobarbital; Rats | 1982 |
The fidelity of mouse liver mitochondrial DNA polymerase following long-term administration of carbon tetrachloride, diethylnitrosamine, or phenobarbital.
Topics: Animals; Carbon Tetrachloride; Chromatography, DEAE-Cellulose; Diethylnitrosamine; DNA-Directed DNA Polymerase; Male; Mice; Mitochondria, Liver; Nitrosamines; Phenobarbital | 1983 |
Dietary cholesterol-induced changes of xenobiotic metabolism in liver. I. Influence of xenobiotic administration on hepatic membrane structure.
Topics: 1-Naphthylamine; Anilino Naphthalenesulfonates; Animals; Body Weight; Carbon Tetrachloride; Cholesterol, Dietary; Fluorescent Dyes; Intracellular Membranes; Liver; Male; Membrane Fluidity; Membrane Lipids; Membrane Proteins; Microsomes, Liver; Organ Size; Phenobarbital; Phospholipids; Rats; Rats, Inbred Strains; Spectrometry, Fluorescence | 1982 |
Lidocaine metabolism and toxicity: a laboratory experiment for dental students.
Topics: Anesthesia, Dental; Anesthesiology; Animals; Carbon Tetrachloride; Lidocaine; Liver; Male; Phenobarbital; Rats; Seizures | 1980 |
Studies on carbon tetrachloride-ethanol interactions in mice.
Topics: Acetaldehyde; Animals; Carbon Tetrachloride; Drug Interactions; Ethanol; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Phenobarbital | 1982 |
Specificity of a phenobarbital-induced cytochrome P-450 for metabolism of carbon tetrachloride to the trichloromethyl radical.
Topics: Animals; Carbon Tetrachloride; Cytochrome P-450 Enzyme System; Enzyme Induction; Free Radicals; Lipid Peroxides; Male; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains | 1982 |
Metabolic activation of carbon tetrachloride: induction of cytochrome P-450 with phenobarbital or 3-methylcholanthrene and its effect on covalent binding.
Topics: Anaerobiosis; Animals; Biotransformation; Carbon Tetrachloride; Cytochrome P-450 Enzyme System; Enzyme Induction; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains | 1982 |
Carbon tetrachloride-mediated expiration of pentane and chloroform by the intact rat: the effects of pretreatment with diethyl maleate, SKF-525A and phenobarbital.
Topics: Animals; Carbon Tetrachloride; Chloroform; Drug Interactions; Glutathione; Lipid Peroxides; Male; Maleates; Pentanes; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains | 1982 |
High yield micronodular cirrhosis in the rat.
Topics: Animals; Ascites; Body Weight; Carbon Tetrachloride; Dose-Response Relationship, Drug; Liver; Liver Cirrhosis, Experimental; Male; Phenobarbital; Rats; Rats, Inbred Strains | 1982 |
Phenobarbitone-induced enlargement of the liver in the rat: its relationship to carbon tetrachloride-induced cirrhosis.
Topics: Animals; Body Weight; Carbon Tetrachloride; Dose-Response Relationship, Drug; Hepatomegaly; Liver; Liver Cirrhosis, Experimental; Male; Organ Size; Phenobarbital; Rats | 1981 |
Role of vasopressin in impaired water excretion in conscious rats with experimental cirrhosis.
Topics: Animals; Arginine Vasopressin; Blood Volume; Body Water; Carbon Tetrachloride; Diabetes Insipidus; Kidney; Liver Cirrhosis, Experimental; Male; Phenobarbital; Rats; Rats, Inbred Strains; Rats, Mutant Strains; Renal Circulation; Sodium; Vasopressins | 1981 |
Toxicity of hymenoxon in Swiss white mice following pretreatment with microsomal enzyme inducers, inhibitors and carbon tetrachloride.
Topics: Animals; Aroclors; Carbon Tetrachloride; Chloramphenicol; Chlorodiphenyl (54% Chlorine); Drug Interactions; Enzyme Induction; In Vitro Techniques; Lethal Dose 50; Liver; Mice; Microsomes, Liver; Phenobarbital; Sesquiterpenes | 1981 |
Effect of tetrachloromethane and other chlorinated hydrocarbons on the hepatic metabolism in the isolated perfused rat liver.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chloroform; Hydrocarbons, Chlorinated; L-Iditol 2-Dehydrogenase; Liver; Male; Methylene Chloride; Phenobarbital; Rats; Rats, Inbred Strains; Trichloroethanes; Trichloroethylene | 1981 |
Significance of 17-hydroxycorticosteroid glucuronide in urine as an index of salicylamide glucuronidation in guinea pigs.
Topics: 17-Hydroxycorticosteroids; Alloxan; Animals; Carbon Tetrachloride; Ethionine; Galactosamine; Glucuronates; Guinea Pigs; Hydrocortisone; Male; Phenobarbital; Salicylamides | 1981 |
Effect of 2-propanol treatment on carbon tetrachloride metabolism and toxicity.
Topics: 1-Propanol; Alanine Transaminase; Animals; Biotransformation; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cytochrome P-450 Enzyme System; Kinetics; Liver; Male; Microsomes, Liver; Phenobarbital; Rats | 1981 |
The effect of dibutyl sulphide on hepatocytes studied by means of the isolated rat liver perfusion after preceding exposure to tetrachloromethane and phenobarbital in vivo.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Liver; Liver Diseases; Perfusion; Phenobarbital; Rats; Sulfides | 1981 |
Prostaglandin-synthesizing system in rat liver: changes with aging and various stimuli.
Topics: Aging; Animals; Arachidonic Acids; Carbon Tetrachloride; Cytosol; Liver; Liver Regeneration; Male; Microsomes, Liver; Phenobarbital; Phospholipids; Prostaglandins; Rats; Tissue Distribution | 1980 |
Carbon tetrachloride-altered binding of carbon monoxide to reduced cytochrome P-450 in phenobarbital microsomes.
Topics: Animals; Carbon Monoxide; Carbon Tetrachloride; Cytochrome P-450 Enzyme System; Male; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Rats | 1980 |
Mechanism of the microsomal reduction of carbon tetrachloride and halothane.
Topics: Animals; Benzopyrenes; Biotransformation; Carbon Tetrachloride; Chloroform; Deuterium; Gas Chromatography-Mass Spectrometry; Halothane; Hydrogen; Male; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Rats | 1981 |
Differential effect of micronodular and biliary cirrhosis on epidermal growth factor receptor expression in the rat.
Topics: Animals; Blotting, Northern; Blotting, Western; Carbon Tetrachloride; ErbB Receptors; Liver; Liver Cirrhosis, Biliary; Liver Cirrhosis, Experimental; Male; Osmolar Concentration; Phenobarbital; Rats; Rats, Sprague-Dawley | 1994 |
Relationship between oxidative hepatic metabolism, urinary sodium excretion and sympathetic nerve activity in experimental cirrhosis in the rat.
Topics: Aminopyrine; Animals; Blood Pressure; Breath Tests; Carbon Tetrachloride; Glomerular Filtration Rate; Liver; Liver Cirrhosis, Experimental; Male; Natriuresis; Norepinephrine; Oxidation-Reduction; Phenobarbital; Rats; Rats, Sprague-Dawley; Sympathetic Nervous System; Water-Electrolyte Balance | 1995 |
Simultaneous induction of liver cirrhosis and hepatocellular carcinomas in F-344 rats: establishment of a short hepatocarcinogenesis model.
Topics: Animals; Carbon Tetrachloride; Carcinogenicity Tests; Carcinogens; Diethylnitrosamine; Hepatectomy; Liver Cirrhosis, Experimental; Liver Neoplasms, Experimental; Male; Phenobarbital; Rats; Rats, Inbred F344; Time Factors | 1994 |
In vivo and in vitro 31P magnetic resonance spectroscopic studies of the hepatic response of healthy rats and rats with acute hepatic damage to fructose loading.
Topics: Adenosine Triphosphate; Animals; Antioxidants; Bromobenzenes; Carbon Tetrachloride; Chromans; Fructose; Fructose-Bisphosphate Aldolase; Fructosephosphates; Glucose-6-Phosphate; Glucosephosphates; Glycerophosphates; Hydrogen-Ion Concentration; In Vitro Techniques; Liver; Magnetic Resonance Spectroscopy; Male; Organophosphates; Phenobarbital; Phosphorus; Phosphorylcholine; Rats; Rats, Wistar; Time Factors; Vitamin E | 1994 |
Detection of liver fibrosis with magnetic cross-relaxation.
Topics: Animals; Body Water; Carbon Tetrachloride; Hydroxyproline; Image Enhancement; Liver; Liver Cirrhosis, Experimental; Magnetic Resonance Imaging; Magnetics; Organ Size; Phenobarbital; Protons; Rats; Rats, Sprague-Dawley | 1994 |
Hyperammonemia induced in rats by inhalation anesthesia with ether.
Topics: Ammonia; Anesthesia, Inhalation; Animals; Carbon Tetrachloride; Ether; Indomethacin; Liver; Male; Phenobarbital; Rats; Rats, Wistar | 1994 |
Decreased hepatocarcinogenic effect of diethylnitrosamine in experimentally induced liver cirrhosis in rat: delay or inhibition?
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Diethylnitrosamine; Liver; Liver Cirrhosis, Experimental; Liver Neoplasms, Experimental; Male; Phenobarbital; Precancerous Conditions; Rats; Rats, Inbred F344; Time Factors | 1994 |
Mechanism of carbon tetrachloride autoprotection: an in vivo study based on 13C-aminopyrine and 13C-galactose breath tests.
Topics: Alanine Transaminase; Aminopyrine; Animals; Aspartate Aminotransferases; Carbon Isotopes; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cytochrome P-450 Enzyme Inhibitors; Galactose; Liver; Liver Function Tests; Male; Phenobarbital; Rats; Rats, Sprague-Dawley; Respiration; Time Factors | 1994 |
Induction of hepatic drug metabolizing enzymes and interaction with carbon tetrachloride in rats after a single oral exposure to atrazine.
Topics: Animals; Atrazine; Carbon Tetrachloride; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Enzyme Induction; Glutathione; Liver; Male; Oxidoreductases; Phenobarbital; Rats; Rats, Wistar | 1993 |
Metabolism of antipyrine in vivo in two rat models of liver cirrhosis. Its relationship to intrinsic clearance in vitro and microsomal membrane lipid composition.
Topics: Animals; Antipyrine; Bile Acids and Salts; Breath Tests; Carbon Tetrachloride; Lipids; Liver Cirrhosis, Biliary; Liver Cirrhosis, Experimental; Male; Membrane Fluidity; Microsomes, Liver; Models, Biological; Organ Size; Phenobarbital; Rats; Rats, Sprague-Dawley; Saliva | 1993 |
Frequency and DNA content of micronuclei in rat parenchymal liver cells during experimental hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Cell Nucleus; Diethylnitrosamine; DNA; Liver; Liver Neoplasms, Experimental; Male; Micronuclei, Chromosome-Defective; Micronucleus Tests; Mitotic Index; Phenobarbital; Rats; Rats, Wistar | 1993 |
Carbon tetrachloride-induced cell death in perfused livers from phenobarbital-pretreated rats under hypoxic conditions and various ionic milieu. Further evidence for calcium-dependent irreversible changes.
Topics: Animals; Calcium; Carbon Tetrachloride; Cell Death; Cell Hypoxia; Cytochrome P-450 Enzyme System; Electrolytes; Fructose; L-Lactate Dehydrogenase; Liver; Male; Necrosis; Perfusion; Phenobarbital; Rats; Rats, Sprague-Dawley; Thiobarbituric Acid Reactive Substances | 1993 |
Distribution of taurine-like immunoreactivity in the mouse liver during ontogeny and after carbon tetrachloride or phenobarbital intoxication.
Topics: Animals; Antibody Specificity; Carbon Tetrachloride; Immunohistochemistry; Liver; Mice; Mice, Inbred ICR; Microscopy, Immunoelectron; Phenobarbital; Taurine | 1993 |
Effect of regeneration and hyperplasia on levels of DNA base oxidation in rat liver.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Carbon Tetrachloride; Cell Division; Deoxyguanosine; Hyperplasia; Liver; Liver Regeneration; Male; Oxidation-Reduction; Phenobarbital; Pyrimidines; Rats; Rats, Inbred F344 | 1993 |
Reduced renal papillary plasma flow in non-ascitic cirrhotic rats.
Topics: Animals; Body Fluids; Carbon Tetrachloride; Diuresis; Hemodynamics; Kidney Medulla; Liver Cirrhosis, Experimental; Male; Natriuresis; Phenobarbital; Rats; Rats, Sprague-Dawley; Renal Circulation | 1993 |
Protective effect of rifampicin against acute liver injury induced by carbon tetrachloride in mice.
Topics: Animals; Carbon Tetrachloride; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Lipid Peroxidation; Liver Diseases; Male; Mice; Mice, Inbred Strains; Phenobarbital; Rifampin; Transaminases | 1995 |
Changes in taurine as an indicator of hepatic dysfunction and biochemical perturbations. Studies in vivo and in vitro.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cells, Cultured; Clenbuterol; Galactosamine; Glutathione; Ketones; Liver; Liver Diseases; Male; Maleates; Necrosis; Phenobarbital; Rats; Rats, Sprague-Dawley; Taurine; Thioacetamide | 1996 |
Transforming growth factor alpha levels in liver and blood correlate better than hepatocyte growth factor with hepatocyte proliferation during liver regeneration.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Cell Division; Dimethylnitrosamine; Disease Models, Animal; Hepatocyte Growth Factor; Liver; Liver Regeneration; Male; Mitotic Index; Necrosis; Phenobarbital; Rats; Rats, Sprague-Dawley; Transforming Growth Factor alpha | 1998 |
Intrahepatic flow disturbance as detected by in vivo acridine orange staining in endothelin-1-treated and cirrhotic rats.
Topics: Acridine Orange; Animals; Carbon Tetrachloride; Endothelin-1; Femoral Vein; Liver; Liver Circulation; Liver Cirrhosis, Experimental; Male; Microcirculation; Microscopy, Fluorescence; Phenobarbital; Portal Pressure; Rats; Rats, Sprague-Dawley | 1998 |
Phenobarbital in comparison with carbon tetrachloride and phenobarbital-induced cirrhosis in rat liver regeneration.
Topics: Animals; Body Weight; Carbon Tetrachloride; Cell Division; DNA; Hepatectomy; Kinetics; Liver; Liver Cirrhosis, Experimental; Liver Regeneration; Male; Organ Size; Phenobarbital; Rats; Rats, Wistar; Reference Values; Thymidine; Time Factors | 1999 |
Effect of mitogenic or regenerative cell proliferation on lacz mutant frequency in the liver of MutaTMMice treated with 5, 9-dimethyldibenzo[c,g]carbazole.
Topics: Animals; Carbazoles; Carbon Tetrachloride; Cell Division; DNA Mutational Analysis; Gene Frequency; Lac Operon; Liver; Liver Regeneration; Male; Mice; Mice, Transgenic; Mitogens; Mutagenicity Tests; Mutation; Organ Size; Phenobarbital | 1999 |
Expression of inositol 1,4,5-trisphosphate receptor isoforms in rat cirrhosis.
Topics: Animals; Bile Ducts; Calcium Channels; Carbon Tetrachloride; Immunohistochemistry; Inositol 1,4,5-Trisphosphate Receptors; Ligation; Liver Cirrhosis, Experimental; Male; Phenobarbital; Protein Isoforms; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; RNA, Messenger | 1999 |
Insulin secretion defects in liver cirrhosis can be reversed by glucagon-like peptide-1.
Topics: Analysis of Variance; Animals; Carbon Tetrachloride; Culture Techniques; Dose-Response Relationship, Drug; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Insulin; Insulin Secretion; Islets of Langerhans; Liver Cirrhosis, Experimental; Liver Function Tests; Male; Peptide Fragments; Phenobarbital; Protein Precursors; Rats; Rats, Inbred Lew | 2000 |
Increased toxin-induced liver injury and fibrosis in interleukin-6-deficient mice.
Topics: Actins; Animals; Apoptosis; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; DNA; DNA-Binding Proteins; Interleukin-6; Kinetics; Liver Cirrhosis, Experimental; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitosis; NF-kappa B; Phenobarbital; STAT3 Transcription Factor; Trans-Activators | 2000 |
Hepatocyte transplantation in rats with decompensated cirrhosis.
Topics: Animals; Bone Marrow Transplantation; Carbon Tetrachloride; Cell Transplantation; Graft Survival; Liver; Liver Cirrhosis, Experimental; Liver Transplantation; Male; Phenobarbital; Rats; Rats, Inbred Lew; Serum Albumin; Spleen; Weight Loss | 2000 |
Effects of IGF-I treatment on osteopenia in rats with advanced liver cirrhosis.
Topics: Animals; Bone and Bones; Bone Density; Bone Diseases, Metabolic; Carbon Tetrachloride; Densitometry; Insulin-Like Growth Factor I; Liver; Liver Cirrhosis, Experimental; Male; Phenobarbital; Random Allocation; Rats; Rats, Wistar | 2000 |
The role of hepatocyte transplantation to treat chronic liver failure.
Topics: Ammonia; Animals; Bilirubin; Carbon Tetrachloride; Cell Transplantation; Chronic Disease; Hepatocytes; Liver Cirrhosis, Experimental; Liver Failure; Male; Phenobarbital; Prothrombin Time; Rats; Rats, Inbred Lew; Serum Albumin | 2000 |
Significance of hepatic arterial responsiveness for adequate tissue oxygenation upon portal vein occlusion in cirrhotic livers.
Topics: Animals; Blood Flow Velocity; Carbon Tetrachloride; Erythrocytes; Female; Liver; Liver Cirrhosis; Male; Microcirculation; Microscopy, Fluorescence; Models, Biological; Oxygen; Oxygen Consumption; Phenobarbital; Portal Vein; Rats; Rats, Sprague-Dawley; Tourniquets | 2000 |
Optimization of an exogenous metabolic activation system for FETAX. II. Preliminary evaluation.
Topics: Abnormalities, Drug-Induced; Animals; beta-Naphthoflavone; Biotransformation; Carbon Tetrachloride; Chloroform; Coculture Techniques; Embryo, Mammalian; Embryo, Nonmammalian; Isoniazid; Microsomes, Liver; Parathion; Phenacetin; Phenobarbital; Rats; Toxicity Tests; Urethane; Xenopus laevis | 2001 |
Influence of phenobarbital and carbon tetrachloride on the modulation of tissue retention profile of hexachlorocyclohexane in rats.
Topics: Animals; Carbon Tetrachloride; Hexachlorocyclohexane; Inactivation, Metabolic; Liver; Liver Function Tests; Male; Organ Size; Phenobarbital; Rats; Tissue Distribution | 2002 |
Protective role of heme oxygenase-1 induction in carbon tetrachloride-induced hepatotoxicity.
Topics: 5-Aminolevulinate Synthetase; Animals; Carbon Tetrachloride; Cytochrome P-450 Enzyme System; Enzyme Induction; Gene Expression; Heme; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hemin; Hepatocytes; Male; Phenobarbital; Protective Agents; Rats; Rats, Sprague-Dawley; Respiratory Distress Syndrome; RNA, Messenger | 2003 |
Effect of ethionine and carbon tetrachloride on urethan and phenobarbital induced changes in hexobarbital action.
Topics: Carbon Tetrachloride; Ethionine; Hexobarbital; Phenobarbital; Urethane | 1961 |
Expression of leptin and leptin receptor during the development of liver fibrosis and cirrhosis.
Topics: Animals; Blotting, Western; Carbon Tetrachloride; Gene Expression Regulation; Immunohistochemistry; Leptin; Liver Cirrhosis; Liver Cirrhosis, Experimental; Male; Phenobarbital; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, Leptin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2004 |
Role of nuclear receptor CAR in carbon tetrachloride-induced hepatotoxicity.
Topics: Androstanols; Animals; Base Sequence; Carbon Tetrachloride; Coxsackie and Adenovirus Receptor-Like Membrane Protein; Cytochrome P-450 Enzyme System; DNA, Complementary; Glutathione; Liver; Mice; Mice, Inbred C3H; Mice, Knockout; Phenobarbital; Receptors, Virus; RNA, Messenger | 2005 |
Bone disorders in experimentally induced liver disease in growing rats.
Topics: Animals; Biomechanical Phenomena; Bone and Bones; Bone Density; Bone Diseases, Metabolic; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Liver Diseases; Male; Phenobarbital; Rats; Rats, Inbred F344 | 2005 |
Effect of phenobarbital on hepatic injury induced by chronic carbon tetrachloride treatment.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drug Synergism; Excitatory Amino Acid Antagonists; Hexobarbital; Liver; Liver Diseases; Male; Phenobarbital; Rats; Rats, Sprague-Dawley | 1981 |
Hepatoprotective activity of Phyllanthus reticulatus.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Euphorbiaceae; Hypnotics and Sedatives; Liver; Liver Diseases; Male; Necrosis; Phenobarbital; Plant Components, Aerial; Protective Agents; Rats; Rats, Long-Evans; Sleep | 2008 |
Hepatoprotective activity of six polyherbal formulations in CCl4-induced liver toxicity in mice.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Liver; Liver Diseases; Mice; Phenobarbital; Phytotherapy; Plant Extracts; Protective Agents; Sleep; Time Factors | 2009 |
Induction of CYP1A1, 2B, 2E1 and 3A in rat liver by organochlorine pesticide dicofol.
Topics: Animals; Blotting, Western; Carbon Tetrachloride; Catalysis; Chemical and Drug Induced Liver Injury; Cyclophilins; Cytochrome P-450 Enzyme System; Dicofol; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Insecticides; Isoenzymes; Liver; Male; Phenobarbital; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sleep | 2009 |
Effect of recombinant human growth hormone and interferon gamma on hepatic collagen synthesis and proliferation of hepatic stellate cells in cirrhotic rats.
Topics: Animals; Carbon Tetrachloride; Cell Proliferation; Cells, Cultured; Collagen Type I; Collagen Type IV; Dose-Response Relationship, Drug; Fluorescent Antibody Technique; Hepatic Stellate Cells; Human Growth Hormone; Humans; Injections, Subcutaneous; Interferon-gamma; Liver; Liver Cirrhosis, Experimental; Male; Phenobarbital; Rats; Rats, Wistar; Recombinant Proteins; Time Factors | 2012 |
A switch in the source of ATP production and a loss in capacity to perform glycolysis are hallmarks of hepatocyte failure in advance liver disease.
Topics: Adenosine Triphosphate; Amino Acids; Animals; Anticonvulsants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cyclooxygenase 1; Cyclooxygenase 2; Disease Models, Animal; Glucose; Glycolysis; Hepatocytes; Humans; Liver Cirrhosis, Experimental; Membrane Proteins; Mitochondria; Oxygen Consumption; Phenobarbital; Rats, Inbred Lew; Severity of Illness Index | 2014 |
Human liver mesenchymal stem/progenitor cells inhibit hepatic stellate cell activation: in vitro and in vivo evaluation.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Cell Proliferation; Coculture Techniques; Culture Media, Conditioned; Disease Models, Animal; Hepatic Stellate Cells; Humans; Liver Cirrhosis; Liver Regeneration; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Phenobarbital; Rats; Rats, Wistar; Time Factors | 2017 |
New Rat Model of Advanced NASH Mimicking Pathophysiological Features and Transcriptomic Signature of The Human Disease.
Topics: Animals; Carbon Tetrachloride; Diet, High-Fat; Disease Models, Animal; Disease Progression; Fatty Liver; Inflammation; Liver; Liver Cirrhosis; Male; Metabolic Syndrome; Non-alcoholic Fatty Liver Disease; Phenobarbital; Rats; Rats, Wistar; Transcriptome | 2019 |
Attenuation of phenobarbital-induced cytochrome P450 expression in carbon tetrachloride-induced hepatitis in mice models.
Topics: Animals; Carbon Tetrachloride; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Gene Expression Regulation, Enzymologic; Hepatitis; Humans; Inflammation; Liver; Mice; Phenobarbital; RNA, Messenger | 2023 |