phenobarbital has been researched along with beta-naphthoflavone in 380 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 182 (47.89) | 18.7374 |
| 1990's | 141 (37.11) | 18.2507 |
| 2000's | 49 (12.89) | 29.6817 |
| 2010's | 8 (2.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Strassburg, CP; Tukey, RH | 1 |
| Choudhuri, S; Guo, GL; Klaassen, CD | 1 |
| Guengerich, FP; Mimura, M; Shimada, T; Yamazaki, H | 1 |
| Bend, JR; Knickle, LC | 2 |
| Goeptar, AR; Neve, EP; Te Koppele, JM; Vermeulen, NP | 1 |
| Bienioszek, M; Plewka, A; Plewka, D | 1 |
| Abou-Donia, MB; Gupta, RP | 1 |
| Banton, MI; Flory, W; Winston, GW | 1 |
| Beaune, PH; Carrière, V; Courtois, YA; de Waziers, I; Leroux, JP | 1 |
| Alldrick, AJ; Brennan-Craddock, WE; Lake, BG; Rowland, IR | 1 |
| Breckenridge, AM; Kitteringham, NR; Park, BK; Pirmohamed, M | 1 |
| Horie, T; Tanaka, S; Yoshimura, T | 1 |
| Kanetoshi, A; May, BK; Rifkind, AB; Ward, AM | 1 |
| Florence, R; McDonnell, WM; Traber, PG; Wang, W | 1 |
| Gannon, M; Nakai, K; Rifkind, AB; Ward, AM | 1 |
| Shimada, T; Yamazaki, H | 1 |
| Castro-Maderal, L; Sullivan, PD | 1 |
| Fujita, S; Hirobe, M; Masubuchi, Y; Narimatsu, S; Ohta, S; Suzuki, T; Tachibana, M | 1 |
| Harbison, RD; James, RC; Roberts, SM; Roth, L; Tobin, T | 1 |
| Harbison, RD; James, RC; Roberts, SM; Roth, L | 1 |
| Combes, RD; Elcombe, CR; Elliott, BM; Gatehouse, DG; Gibson, GG; Mackay, JM; Wolf, RC | 1 |
| Kato, R; Kawanishi, T; Kawano, S; Ohno, Y; Omori, Y; Takanaka, A; Yamazoe, Y | 1 |
| Nakanishi, S; Nishiguchi, K; Serasinghe, P; Serasinghe, S; Yamazaki, H | 1 |
| Sipes, IG; Weber, GL | 1 |
| Friis, C; Nielsen, P; Thomsen, MK | 1 |
| Groh, T; Müller, D; Splinter, FK | 1 |
| Koleva, M; Staneva-Stoytcheva, D | 1 |
| Blaauboer, BJ; de Kruif, CA; Falke, HE; Noordhoek, J; van Iersel, AA; Wortelboer, HM | 1 |
| Boiadzhieva, N; Nedzhar, A; Stoĭchev, Ts | 1 |
| Jefcoate, C; Marcus, C; Otto, S; Pidgeon, C; Stevens, J | 1 |
| Rosenberg, DW | 1 |
| Ariyoshi, T; Arizono, K; Hasegawa, H; Matsumoto, H | 1 |
| Brambilla, G; Mattioli, F; Robbiano, L | 1 |
| Barrueco, C; de la Peña, E; Herrera, A | 1 |
| Foth, H; Kahl, GF; Looschen, H; Neurath, H | 1 |
| Mizutani, T; Nakanishi, K; Nomura, H; Satoh, K | 1 |
| Czekaj, P; Nowaczyk-Dura, G; Plewka, A | 1 |
| Chambers, MA; Gelboin, HV; Gerber, N; Hilliard, JB; Mays, DC; Park, SS; Wong, DD | 1 |
| Manning, RO; Marks, HL; Wyatt, RD | 1 |
| Di Folco, S; Stammati, A; Vittozzi, L; Zucco, F | 1 |
| Bennett, BM; McDonald, BJ | 1 |
| Hänninen, O; Kaliste-Korhonen, E; Törrönen, R; Ylitalo, P | 1 |
| Abou-Donia, MB; Gupta, RP; Lapadula, DM | 1 |
| Bui, QD; Weisz, J; Wrighton, SA | 1 |
| Marks, GS; Riddick, DS | 1 |
| Bend, JR; Woodcroft, KJ | 1 |
| Larson, RE; Stolzenbach, JC | 1 |
| Chambers, HW; Chambers, JE | 1 |
| Kitteringham, NR; Park, BK; Riley, RJ; Roberts, P | 1 |
| Capdevila, JH; Falck, JR; Guenguerich, FP; Karara, A; Martin, MV; Waxman, DJ | 1 |
| Gibson, GG; MacNicoll, AD; Sutcliffe, FA | 1 |
| Fry, JR; Hammond, AH | 1 |
| Etoh, H; Misawa, S; Tanaka, E | 1 |
| Jahn, F; Karge, E; Klinger, W | 1 |
| Gelboin, HV; Marks, GS; Park, SS; Riddick, DS | 2 |
| Forkert, PG; Gelboin, HV; Mirehouse-Brown, P; Park, SS | 1 |
| Becket, G; Hu, GT; Koh, OS; Lee, EJ; Moochhala, SM | 1 |
| Bidgood, J; Kirkland, DJ; Marshall, RR; McEnaney, S; Mullineux, S; Rutter, A | 1 |
| Elskus, AA; Stegeman, JJ | 1 |
| Gerber, N; Hilliard, JB; Mays, DC; Wong, DD | 1 |
| Delaforge, M; Mansuy, D; Sartori, E | 1 |
| Brock, KH; Moore, MM; Oglesby, LA | 1 |
| Alexander, J; Becher, G; Holme, JA; Wallin, H | 1 |
| Chambers, JE; Forsyth, CS | 1 |
| Batt, AM; Gielen, J; Kremers, P; Siest, G; Totis, M; Van Cantfort, J | 1 |
| Bars, RG; Elcombe, CR; Mitchell, AM; Wolf, CR | 1 |
| Brun-Pascaud, M; Gougerot-Pocidalo, MA; Hakim, J; Mansour, H; Marquetty, C; Pocidalo, JJ | 1 |
| Blumer, JL; Frank, DM | 1 |
| Dalich, GM; Larson, RE | 1 |
| Chenery, RJ; Norman, SJ; Oldham, HG | 1 |
| Brindley, WA; Hincks, JR | 2 |
| Bawden, MJ; Hansen, AJ; May, BK; Srivastava, G | 1 |
| Bend, JR; Foureman, GL; Guengerich, FP; Harris, C | 1 |
| Fry, JR; Warren, M | 1 |
| Conolly, RB; Osimitz, TG | 1 |
| Hook, JB; Rush, GF; Smith, JH | 1 |
| Cantelli-Forti, G; Grilli, S; Hrelia, P; Paolini, M; Sapigni, E | 1 |
| Koliada, AIu | 1 |
| Brun-Pascaud, M; Gougerot-Pocidalo, MA; Mansour, H; Pocidalo, JJ | 1 |
| Levine, WG; Raza, H | 1 |
| Bauer, C; Bronzetti, G; Corsi, C; Paolini, M; Tonelli, F | 1 |
| Oshinsky, RJ; Strobel, HW | 1 |
| Bachmann, KA; Jahn, D; Schwartz, J; Yang, C | 1 |
| Buffoni, F; Cintelli, A; Ignesti, G; Perretti, M | 1 |
| De Matteis, F; Lock, EA; Reed, CJ | 1 |
| Haasch, ML; Kleinow, KM; Lech, JJ | 1 |
| Cantrill, E; Farrell, GC; Murray, M | 1 |
| Azoulay-Dupuis, E; Gougerot-Pocidalo, MA; Levacher, M; Mansour, H; Marquetty, C; Moreau, J | 1 |
| Benjamin, T; Grantham, PH; Ramanathan, R; Reddy, TV; Weisburger, EK | 1 |
| Meneguz, A; Michalek, H | 1 |
| Hänninen, O; Lindström-Seppä, P | 1 |
| Andersson, T; Förlin, L; Goksøyr, A; Hansson, T; Klungsøyr, J; Zhang, Y | 1 |
| Belinsky, SA; Kari, FW; Kauffman, FC; Thurman, RG | 1 |
| Boobis, AR; Davies, DS; Elcombe, CR; Foster, JR; Hayward, C; Lock, EA; McQuade, J; Robson, RT; Sesardic, D | 1 |
| Francis, JE; Smith, AG | 1 |
| Karge, E; Klinger, W | 1 |
| Abbruzzi, R; Bastone, A; Bianchi, M; Bonati, M; Catalani, P; Guaitani, A; Latini, R; Pantarotto, C; Szczawinska, K | 1 |
| Chen, IW; Duggan, DE; Lin, JH; Ulm, EH | 1 |
| Foth, H; Kahl, GF; Rüdell, U | 1 |
| Bonfils, C; Dalet, C; Daujat, M; Guzelian, PS; Larroque, C; Li, D; Maurel, P; Pichard, L; Pompon, D | 1 |
| Ardies, CM; Lasker, JM; Lieber, CS | 1 |
| Matsubara, T; Touchi, A; Yamada, N | 1 |
| Saitoh, T; Sudoh, A; Umezu, K; Yuasa, S | 1 |
| Gram, TE; Okine, LK | 1 |
| Aranda, JV; Beharry, K; Clozel, M | 1 |
| Lau, PP; Strobel, HW; Sun, JQ | 1 |
| De Matteis, F; Gibbs, AH | 1 |
| Gilmour, SK; Kalf, GF; Snyder, R | 1 |
| Chism, JP; Kedderis, GL; Rickert, DE | 1 |
| Buhler, DR; Kedzierski, B | 1 |
| Degawa, M; Hashimoto, Y; Kojima, M; Sato, Y | 1 |
| Clarke, L; Frey, AB; Kreibich, G; Wadhera, AB; Waxman, DJ | 1 |
| Flory, W; Henk, WG; Turk, MA | 1 |
| Brandt, I; Klasson-Wehler, E; Lund, BO | 1 |
| De Matteis, F; Harvey, C; Martin, SR | 1 |
| Topp, RJ; van Bladeren, PJ | 1 |
| Kleeberg, U; Klinger, W; Sommer, M | 1 |
| Hetnarski, K; Murray, M; Wilkinson, CF | 2 |
| Klinger, W; Müller, D | 1 |
| Heinemeyer, G; Hildebrandt, AG; Nau, H; Roots, I | 1 |
| Glaumann, H; Gustafsson, JA; Haaparanta, T; Haglund, L; Norgård, M | 1 |
| Malejka-Giganti, D; Ryzewski, CN | 1 |
| Kamataki, T; Kato, R; Kawano, S; Maeda, K; Mizoguchi, I; Nakao, T | 1 |
| McKillop, D | 1 |
| Ozols, J | 1 |
| Decker, RW; Malejka-Giganti, D; Polovina, MR; Ritter, CL | 1 |
| Billings, RE; Dankovic, D; Seifert, W; Stillwell, WG | 1 |
| Buhler, DR; Carpenter, HM; Williams, DE | 1 |
| Kappas, A; Rosenberg, DW; Sardana, MK | 1 |
| Juchau, MR; Namkung, MJ; Nelson, SD; Porubek, DJ | 1 |
| Fischbach, T; Lenk, W | 1 |
| Ahmed, AE; Gad-el-Karim, MM; Legator, MS; Ramanujam, VM | 1 |
| Alworth, WL; Gan, LS; Hershkowitz, DM; Lu, JY | 1 |
| Elcombe, CR; Houston, JB; Taylor, G | 1 |
| Balfour, C; Dunbar, D; Halpert, J; Kaminsky, LS; Miller, NE; Morgan, ET | 1 |
| Matsubara, T; Nishiyama, S; Touchi, A; Yamada, N | 1 |
| Dietz, D; Kornbrust, D | 1 |
| Greiling, H; Greiling, K; Klinger, W; Müller, D | 1 |
| Hook, JB; Kuo, CH | 1 |
| Bradshaw, JJ; Ivanetich, KM; Ziman, MR | 1 |
| Lech, JJ; Rau, LA; Vodicnik, MJ | 1 |
| Fujino, T; Gelboin, HV; Guengerich, FP; Park, SS; West, D | 1 |
| Ashworth, A; Phillips, IR; Pike, SF; Rabin, BR; Shephard, EA | 1 |
| Buhler, DR; Williams, DE | 1 |
| Murphy, SD; Shao, M; Sultatos, LG | 1 |
| Wang, IY | 1 |
| Gelboin, HV; Gozukara, EM; Guengerich, FP; Miller, H | 1 |
| Bösterling, B; Stier, A | 1 |
| Abdel-Tawab, GA; El-Bassiouni, EA; El-Sebae, AH; El-Sewedy, SM; El-Zoghby, SM; Mostafa, MH; Ramadan, M | 1 |
| Atuma, S; Blanck, A; Hällstöm, I | 1 |
| Shertzer, HG | 2 |
| Davis, M; Smith, HM; Tredger, JM; Williams, R | 1 |
| Ahmadizadeh, M; Echt, R; Hook, JB; Kuo, CH | 1 |
| Gadeholt, G | 1 |
| Busk, L; Gustafsson, JA; Söderkvist, P; Toftgård, R | 1 |
| Chopy, C; Lequesne, N; Mayet, MJ; Shahin, MM | 1 |
| Masaki, R; Matsuura, S; Tashiro, Y | 1 |
| Desai, CD; Sitar, DS | 1 |
| Bloom, SE; Denison, MS; Hamilton, JW | 1 |
| Chiang, JY; DiLella, AG; Steggles, AW | 1 |
| Bayney, RM; Phillips, IR; Pike, SF; Rabin, BR; Shephard, EA | 1 |
| De Verneuil, H; Kappas, A; Sassa, S | 1 |
| Glaumann, H; Gustafsson, JA; Haaparanta, T; Halpert, J | 1 |
| Guengerich, FP; Shiraki, H | 1 |
| Bender, RC; Buhler, DR; Carpenter, HM; Henderson, MC; Williams, DE | 1 |
| Bradshaw, JJ; Ivanetich, KM | 1 |
| Fagan, J; Gelboin, HV; Gozukara, EM; Guengerich, FP; Pastewka, JV | 1 |
| Acebo, AL; Alworth, WL; Gan, LS | 1 |
| Gerber, N; Guiler, RC; Hecht, S; Mays, DC; Rogers, SL; Sharp, DE | 1 |
| Bursian, SJ; Calabrese, LF | 1 |
| Fry, JR; Horner, SA; Paterson, P | 1 |
| Bäärnhielm, C; Borg, KO; Skånberg, I | 1 |
| Ashworth, A; Phillips, IR; Shephard, EA | 1 |
| McDanell, RE; McLean, AE | 1 |
| Della Porta, G; Dragani, TA; Sozzi, G | 1 |
| Kappas, A; Sassa, S; Schneider, J | 1 |
| Matsubara, T; Otsubo, S; Yoshihara, E | 1 |
| Mostafa, MH; Ruchirawat, M; Weisburger, EK | 1 |
| Murray, M; Ryan, AJ | 1 |
| Lake, BG; Paine, AJ | 1 |
| Jahn, F; Kadiiska, M; Klinger, W; Stoytchev, T | 1 |
| Ashworth, A; Phillips, IR; Rabin, BR; Shephard, EA | 1 |
| Dannan, GA; Guengerich, FP; Kaminsky, LS | 1 |
| Murray, M; Wilkinson, CF | 1 |
| Dannan, GA; Guengerich, FP; Kaminsky, LS; Martin, MV; Wright, ST | 1 |
| Cazer, FD; Hart, RW; Sheikh, YM; Witiak, DT | 1 |
| Muta, E; Tsuji, H; Ullrich, V | 1 |
| Guengerich, FP; Martin, MV | 1 |
| Guengerich, FP; Kaminsky, LS; Kennedy, MW | 1 |
| Davis, M; Powell-Jackson, PR; Smith, HM; Tredger, JM; Williams, R | 1 |
| Notley, BA; Rikans, LE | 2 |
| Dunbar, DA; Guengerich, FP; Kaminsky, LS; Murphy, MJ | 1 |
| Batt, AM; Martin, N; Siest, G | 1 |
| Bock, KW; Lilienblum, W; Walli, AK | 1 |
| Clark, JD; Hatch, RC; Jain, AV; Mahaffey, EA; Weiss, R | 1 |
| Hansson, R; Wikvall, K | 1 |
| Bryant, BJ; Easterling, R; Nesnow, S; Rudo, K | 1 |
| Dubé, CE; Murray, M; Wilkinson, CF | 1 |
| Steggles, AW; Vlasuk, GP; Walz, FG | 1 |
| Highet, RJ; Jerina, DM; Levin, W; Ryan, DE; Shibata, T; Thomas, PE; Vyas, KP; Yeh, HJ | 1 |
| Nesnow, S | 1 |
| Battershill, JM; Gibson, GG; Ioannides, C; Masson, HA; Steele, CM | 1 |
| De Matteis, F; Gibbs, AH; Hollands, C | 1 |
| Bayney, RM; Carter, N; Heath, R; Phillips, IR; Pike, SF; Rabin, BR; Shephard, EA | 1 |
| Columelli, S; Cresteil, T; le Provost, E; Leroux, JP | 1 |
| Bauer, C; Bronzetti, G; Corsi, C; Del Carratore, R; Nieri, R; Paolini, M | 1 |
| Franklin, MR; Pershing, LK | 1 |
| Aune, T; Dybing, E; Nelson, SD | 1 |
| Hales, BF; Jain, R | 1 |
| Hales, BF | 1 |
| Gray, RD | 1 |
| Baron, J; Guengerich, FP; Redick, JA | 1 |
| Bush, ED; Trager, WF | 1 |
| Kurogochi, Y; Nakashima, T; Nakayama, H | 1 |
| Gustafsson, JA; Söderkvist, P; Toftgard, R | 1 |
| Clark, JD; Hatch, RC; Jain, AV; Weiss, R | 1 |
| Bornheim, LM; Franklin, MR | 1 |
| Atias, A; Morello, A; Repetto, Y | 1 |
| Bauer, C; Bronzetti, G; Corsi, C; Del Carratore, R; Morelli, M; Nieri, R; Paolini, M | 1 |
| Hajek, KK; Novak, RF | 1 |
| Matsubara, T; Ogawa, A; Touchi, A | 1 |
| Duvivier, J; Gielen, JE; Van Cantfort, J | 1 |
| Garattini, E; Gazzotti, G; Salmona, M | 1 |
| Bergman, H; Nesnow, S | 1 |
| Lau, SS; Zannoni, VG | 1 |
| Althaus, FR; Meyer, UA | 1 |
| Porter, WR; Trager, WF; Wheeler, C | 1 |
| Jonen, HG; Kaufmann, I | 1 |
| Hudson, P; Kao, J | 1 |
| Gordon, ER; Sitar, DS | 1 |
| Jensen, NM; Nebert, DW; Oka, T; Perry, JW | 1 |
| Fasco, MJ; Kaminsky, LS; McMartin, DN; O'Connor, JA | 1 |
| Boone, JS; Chambers, HW; Chambers, JE; Ma, T | 1 |
| Bracken, W; Bullock, P; Draper, A; Parkinson, A; Pearce, R; Podval, J; Thomas, P; Veltman, J | 1 |
| McNamara, PJ; Small, DS | 1 |
| Barrenscheen, M; Doehmer, J; Glatt, HR; Goeptar, AR; Groot, EJ; Seidel, A; te Koppele, JM; Vermeulen, NP; Wölfel, C | 1 |
| Brouwer, A; Klasson Wehler, E; Morse, DC; Van Bladeren, PJ | 1 |
| Brown, PI; Lo, HH; Rankin, GO; Valentovic, MA | 1 |
| Boersma, MG; Koerts, J; Rietjens, IM; Vervoort, J | 1 |
| Kamiński, M; Plewka, A; Plewka, D | 1 |
| Konishi, H; Morita, K; Yamaji, A | 1 |
| Koleva, MR; Stoychev, TS | 1 |
| Albano, E; Clot, P; Comoglio, A; Iannone, A; Ingelman-Sundberg, M; Tomasi, A | 1 |
| Omiecinski, CJ; Sidhu, JS | 1 |
| Hirata, M; Nishibe, Y | 2 |
| Carlson, GP | 2 |
| Adamo, D; Bassi, AM; Castell, JV; Donato, MT; Ferro, M; Gómez-Lechón, MJ; Herrero, E; Penco, S | 1 |
| Carlson, GP; Gadberry, MG | 1 |
| Allentoff, AJ; Correia, MA; Thompson, JA; Wrighton, SA; Yao, K | 1 |
| Bauer, C; Corsi, C; Paolini, M | 1 |
| Bend, JR; Knickle, LC; Philpot, RM | 1 |
| Cresteil, T; Gonzalez, FJ; Kersual, J; Marie, S; Sonnier, M | 1 |
| Jenner, AM; Timbrell, JA | 1 |
| Johnson, S; McKillop, D; Miller, J; Smith, IK | 1 |
| Martini, R; Murray, M | 1 |
| Bienioszek, M; Plewka, A | 1 |
| Schenkman, JB; Voznesensky, AI | 1 |
| Kupfer, D; Lee, CA; Mani, C; Rifkind, AB | 1 |
| Pearson, WR; Sisk, SC | 1 |
| Crankshaw, D; Reicks, MM | 1 |
| Blouin, RA; Chaudhary, IP; Cibull, M; Robertson, LW; Tuntaterdtum, S | 1 |
| Hamilton, SM; Miller, CH; Teel, RW; Zhang, Z | 1 |
| Blain, PG; McCracken, NW; Williams, FM | 1 |
| Jaw, S; Jeffery, EH | 1 |
| Leff, T; Rosenberg, DW | 1 |
| Blaauboer, BJ; Horbach, GJ; Natsuhori, M; Noordhoek, J; van Miert, AS; van't Klooster, GA | 1 |
| Brouland, JP; Descotes, J; Patriarca, C; Verdier, F | 1 |
| Blaauboer, BJ; Luijckx, NB; Mennes, WC; Noordhoek, J; Wortelboer, HM | 1 |
| Kharasch, ED; Thummel, KE | 1 |
| Albano, E; Biocca, ME; Cheeseman, KH; Dianzani, MU; Gilmore, KS; Ketterer, B; Leonarduzzi, G; Meyer, DJ; Parola, M; Slater, TF | 1 |
| Hodgson, AV; Strobel, HW; White, JW; White, TB | 1 |
| Beamand, JA; Davies, S; Japenga, AC; Lake, BG; Price, RJ; Renwick, A | 1 |
| Guzelian, PS; Kocarek, TA; Schuetz, EG | 1 |
| Bronzetti, G; Del Carratore, R; Della Croce, C; Morichetti, E | 1 |
| Jansson, I; Schenkman, JB | 1 |
| Gorrod, JW; Sai, Y | 1 |
| Callander, RD; Clay, P; Elcombe, CR; Elliott, BM; Mackay, JM | 1 |
| Kimmett, SM; Marks, GS; Whitney, RA | 1 |
| Franklin, MR; Moody, DE; Slawson, MH | 1 |
| Commandeur, JN; Ploemen, JH; van Bladeren, P; van Ommen, B; Vermeulen, NP; Wormhoudt, LW | 1 |
| Buzukov, AA; Degterev, IA; Il'asova, VB; Meirelles, NC; Tabak, M | 1 |
| Cvrk, T; Hodek, P; Strobel, HW | 1 |
| Carlson, GP; DeNicola, DB; Gadberry, MG | 1 |
| Castonguay, A; Miller, C; Teel, RW | 1 |
| Galloway, SM; Johnson, TE; Umbenhauer, DR | 1 |
| Beamand, JA; Charzat, C; Lake, BG; Price, RJ; Renwick, AB; Tredger, JM | 1 |
| Bos, RP; de Roos, JH; Noordhoek, J; Sessink, PJ; Vaes, WH; van den Broek, PH | 1 |
| Baba, T; Eguchi, K; Nishibe, Y; Ohno, K | 1 |
| Bend, JR; Krug, P; McCallum, GP; Weedon, AC | 1 |
| Fry, JR; Garle, MJ; Giurnazi, AM; Lal, K | 1 |
| Bergh, AF; Strobel, HW | 1 |
| Cantoni, L; Carelli, M; Porras, MC; Rizzardini, M | 1 |
| Batzias, J; Horbach, GJ; Maas, RF; van Miert, AS; Witkamp, RF; Zweers-Zeilmaker, WM | 1 |
| Blain, PG; Crosbie, SJ; Williams, FM | 1 |
| De Curtis, V; Fabrizi, L; Gemma, S; Gervasi, P; Testai, E; Vittozzi, L | 1 |
| Altuntas, TG; Gorrod, JW | 1 |
| Iwersen, S; Schmoldt, A | 1 |
| Amacher, DE; Schomaker, SJ | 1 |
| Carlson, GP; DeNicola, DB; Felten, RK | 1 |
| Avadhani, NG; Bhagwat, SV; Mullick, J; Raza, H | 1 |
| Danz, M; Hänninen, O; Klinger, W; Koponen, K; Lindström-Seppa, P; Lucas, N; Lupp, A | 1 |
| Hänninen, O; Kaliste-Korhonen, E; Tuovinen, K | 1 |
| Bergman, A; Brouwer, A; Legger, FF; Moonen, MJ; Schuur, AG; van Leeuwen-Bol, I; van Meeteren, ME; Visser, TJ | 1 |
| Chui, YC; He, SX; Law, FC | 1 |
| De Matteis, F; Frosini, M; Palmi, M; Sgaragli, G; Valoti, M | 1 |
| Carmichael, N; Debruyne, E; Lassere, D; Nicod, L; Richert, L; Viollon-Abadie, C | 1 |
| Klinger, W; Krausse, T; Lau, K; Lupp, A; Trautmann, AK | 1 |
| Chikaoka, Y; Tamura, M | 1 |
| Carroll, K; DeHaan, R; LeCluyse, E; Madan, A; Mudra, D; Parkinson, A | 1 |
| Carletti, M; Ceppa, L; Dacasto, M; Nebbia, C | 1 |
| Carlile, DJ; Hakooz, N; Houston, JB | 1 |
| Melancon, MJ; Renauld, AE; Sordillo, LM | 1 |
| Gibson, GG; Goldfarb, PS; Gray, TJ; Ogg, MS; Tarbit, M; Williams, JM | 1 |
| Domínguez, G; García Franco, S; Pico, JC | 1 |
| Burke, MD; Dickins, M; Weaver, RJ | 1 |
| Matsui, H; Ohhira, S; Watanabe, K | 1 |
| Bani, M; Brogin, G; Hengstler, JG; Oesch, F; Strolin-Benedetti, M | 1 |
| Kamiński, M; Nowaczyk, G; Plewka, A; Plewka, D | 1 |
| Murray, M; Trieu, L | 1 |
| Frosini, M; Fusi, F; Pessina, F; Sgaragli, GP; Tipton, KF; Valoti, M | 1 |
| Ahlgren-Beckendorf, JA; Carroll, K; Johnson, J; LeCluyse, EL; Parkinson, A | 1 |
| Fleig, WE; Jäger, D; Köhler, C; Kostrubsky, VE; Lehmann, T; May, U; Michalopoulos, GK; Runge, D; Runge, DM; Stolz, DB; Strom, SC | 1 |
| Anderson, LM; Grady, JJ; Jones, AB; Josyula, S; Lu, LJ; Nerurkar, PV; Salazar, JJ; Snyderwine, EG | 1 |
| Berger, Y; Bourrié, M; Fabre, G; Guillou, F; Julian, B; Marti, E; Meunier, V | 1 |
| Kagayama, A; Mitani, Y; Niwa, T; Shiraga, T; Terakawa, M; Tokuma, Y | 1 |
| Amato, G; Gervasi, PG; Giorgi, M; Longo, V; Marini, S; Mazzaccaro, A | 1 |
| Bigot-Lasserre, D; Carmichael, N; Nicod, L; Richert, L; Viollon-Abadie, C | 1 |
| Evans, DC; Lake, BG; Meneses-Lorente, G; Price, RJ; Renwick, AB; Surry, D | 1 |
| Danz, M; Lupp, A; Müller, D | 3 |
| Finch, RA; Fort, DJ; Rogers, RL; Stover, EL | 1 |
| Finch, RA; Fort, DJ; Paul, RR; Rogers, RL; Stover, EL | 1 |
| Kuhn, UD; Müller, D; Rost, M | 1 |
| Dusatti, F; Ferro, M; Gelardi, A; Morini, F; Penco, S | 1 |
| Backes, WL; Cawley, GF; Kelley, RW; Zhang, S | 1 |
| Danz, M; Klinger, W; Lupp, A; Müller, D | 1 |
| Antonian, L; Burton, LA; Carroll, KM; Czerwinski, M; Downey, AD; Forster, J; Gan, LS; Graham, RA; Koch, P; Krueger, LA; LeCluyse, EL; Madan, A; Mudra, DR; Parkinson, A; Ribadeneira, MD; Robertson, P; Wagner, G; Yu, L; Zech, K | 1 |
| Lake, BG; Meredith, C; Price, RJ; Renwick, AB; Scott, MP | 1 |
| Siegmund, W; Thummler, D; Ullmann, C; Walter, R | 1 |
| Myers, S; Robertson, LW; Tampal, N | 1 |
| Danz, M; Hugenschmidt, S; Lupp, A; Müller, D | 1 |
| Brown, D; Scott, JG; Wen, Z; Zhang, L | 1 |
| Fiala-Beer, E; Murray, M; Sutton, D | 1 |
| Miyazawa, M; Shimada, T; Sugie, A | 1 |
| Donald, S; Gescher, AJ; Greaves, P; Jimeno, J; Orr, S; Verschoyle, RD | 1 |
| Hu, YZ; Yao, TW | 1 |
| Hugenschmidt, S; Lupp, A; Müller, D; Rost, M | 1 |
| Angelucci, S; Bucci, S; Gervasi, PG; Longo, V; Marini, S; Salvetti, A | 1 |
| Damani, LA; Nnane, IP | 1 |
| de Kanter, R; Grossi, P; Mahnke, A; Martignoni, M; Monshouwer, M; Saturno, G | 1 |
| Bass, AE; Bruce, G; Bylov, IE; Fry, JR; Hammond, AH; Jassi, KL; Kovalenko, SM; Laughton, C; Shaw, PN | 1 |
| Amin, S; Desai, D; Lin, JM; Sharma, AK | 1 |
| Jemnitz, K; Török, G; Tóth, E; Vereczkey, L; Veres, Z | 1 |
| Barbaria, E; de Kanter, R; Grossi, P; Martignoni, M; Monshouwer, M; Saturno, G | 1 |
| Ashby, CA; Ayrton, AD; Baldwin, SJ; Bramhall, JL; Clarke, SE; Hood, SR; Murdock, PR; Yue, L | 1 |
| Banks, T; Chen, L; Clark, P; Graham, RA; Krol, WL; LeCluyse, EL; Silver, IS; Tyler, LO; Webster, LO | 1 |
| Adam, G; Fleck, C; Karge, E; Kuhn, UD; Lupp, A | 1 |
| Commandeur, JN; Irth, H; Kool, J; van Elswijk, DA; van Liempd, SM; van Rossum, H; Vermeulen, NP | 1 |
| Coelho-Palermo Cunha, G; van Ravenzwaay, B | 1 |
| Etzrodt, J; Glöckner, R; Lupp, A; Müller, D | 1 |
| Hayashi, M; Kishida, T; Kuroda, J; Murakami, M; Muto, S; Tanaka, S; Tsutsui, M | 1 |
| Chu, I; Gu, YZ; Kumari, P; Lin, X; Mandakas, G; Palamanda, J; Smith, RJ; Snyder, RD; Soares, A; Wang, EJ | 1 |
| Abadie-Viollon, C; Alexandre, E; Bachellier, P; Blanchard, N; Coassolo, P; Heyd, B; Mantion, G; Martin, H; Pekthong, D; Richert, L; Schuler, F | 1 |
| Grubbs, CJ; Lubet, RA; Wang, Y; Yao, R; You, M | 1 |
| Callendrello, AL; Crespi, CL; Ho, T; Stresser, DM; Zhang, JG | 1 |
| Correa-Basurto, J; Mendieta-Wejebe, JE; Rosales-Hernández, MC; Trujillo-Ferrara, JG | 1 |
| Hanafusa, H; Hanioka, N; Iwabu, H; Nakada, S; Narimatsu, S | 1 |
| Chatuphonprasert, W; Jarukamjorn, K; Lao-ong, T; Rermraksakul, P; Udomsuk, L | 1 |
| Batheja, A; Chattopadhyay, S; Dallas, S; Sensenhauser, C; Silva, J; Singer, M | 1 |
| Cheng, Y; Dong, Z; Liu, S; Rao, M; Tang, M | 1 |
| Arakawa, S; Hasegawa, T; Kishino, Y; Mori, K; Shibaya, Y; Yamoto, T | 1 |
3 review(s) available for phenobarbital and beta-naphthoflavone
| Article | Year |
|---|---|
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic | 2000 |
[Effects of age and selected inductors of aromatic hydrocarbon hydroxylase (AHH) activity in the rat liver].
Topics: Aging; Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; beta-Naphthoflavone; Dexamethasone; Enzyme Induction; Male; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains | 1990 |
[Induced modifications of liver cytochrome P-450 levels as a function of age in rats].
Topics: Aging; Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Dexamethasone; Liver; Phenobarbital; Rats | 1994 |
377 other study(ies) available for phenobarbital and beta-naphthoflavone
| Article | Year |
|---|---|
Induction profile of rat organic anion transporting polypeptide 2 (oatp2) by prototypical drug-metabolizing enzyme inducers that activate gene expression through ligand-activated transcription factor pathways.
Topics: Animals; Blotting, Northern; DNA Probes; Enzyme Induction; Gene Expression Regulation, Enzymologic; Ligands; Liver; Liver-Specific Organic Anion Transporter 1; Male; Membranes; Pharmaceutical Preparations; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription Factors; Transcription, Genetic | 2002 |
Rat pulmonary microsomal cytochrome P-450 enzymes involved in the activation of procarcinogens.
Topics: Aflatoxins; Animals; Benzoflavones; beta-Naphthoflavone; Biotransformation; Carcinogenicity Tests; Carcinogens; Cytochrome P-450 Enzyme System; DNA; DNA Damage; In Vitro Techniques; Lung; Male; Microsomes; Microsomes, Liver; Phenobarbital; Pregnenolone; Rats; Rats, Sprague-Dawley; Safrole; SOS Response, Genetics; Sterigmatocystin | 1992 |
Dose-dependent, mechanism-based inactivation of cytochrome P450 monooxygenases in vivo by 1-aminobenzotriazole in liver, lung, and kidney of untreated, phenobarbital-treated, and beta-naphthoflavone-treated guinea pigs.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Guinea Pigs; Isoenzymes; Kidney; Liver; Lung; Male; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Triazoles | 1992 |
Reductase and oxidase activity of rat liver cytochrome P450 with 2,3,5,6-tetramethylbenzoquinone as substrate.
Topics: Animals; Benzoflavones; Benzoquinones; beta-Naphthoflavone; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Electron Spin Resonance Spectroscopy; Enzyme Induction; Hydrogen Peroxide; Male; Microsomes, Liver; Oxidoreductases; Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains; Spin Labels; Superoxides; Xanthine Oxidase | 1992 |
[Effect of age and inductors on UDP-glucuronyltransferase activity].
Topics: Aging; Animals; Benzoflavones; beta-Naphthoflavone; Dexamethasone; Glucuronosyltransferase; Male; Microsomes, Liver; Phenobarbital; Rats; Rats, Wistar | 1992 |
Ethanol-inducible microsomal aniline hydroxylase activity and cytochrome P-450 isozymes in adult hen liver.
Topics: Aniline Hydroxylase; Animals; Benzoflavones; beta-Naphthoflavone; Catalysis; Chickens; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Enzyme Induction; Ethanol; Female; Isoenzymes; Kinetics; Metyrapone; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital | 1992 |
Liver microsomal alkoxyphenoxazone O-dealkylases of white Leghorn chickens: response to mixed function oxidase inducers.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Chickens; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Enzyme Induction; Male; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Rats; Rats, Sprague-Dawley | 1992 |
Cytochrome P450 induction and mutagenicity of 2-aminoanthracene (2AA) in rat liver and gut.
Topics: Acetone; Animals; Anthracenes; Benzoflavones; beta-Naphthoflavone; Biotransformation; Blotting, Western; Colon; Cytochrome P-450 Enzyme System; Dexamethasone; Intestine, Small; Liver; Male; Mutagenicity Tests; Mutagens; Phenobarbital; Rats; Rats, Inbred Strains; Salmonella typhimurium | 1992 |
Effect of hepatic cytochrome P-450 inducing agents on mutagen activity in the host-mediated assay.
Topics: Aflatoxins; Analysis of Variance; Animals; Benzoflavones; beta-Naphthoflavone; Carcinogens; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Liver; Mice; Mice, Inbred BALB C; Mutagenesis; Mutagenicity Tests; Mutagens; Phenobarbital; Quinoxalines; Salmonella typhimurium | 1992 |
The effect of enzyme induction on the cytochrome P450-mediated bioactivation of carbamazepine by mouse liver microsomes.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Biotransformation; Carbamazepine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Hydrocortisone; Immunoblotting; Male; Mice; Mice, Inbred CBA; Microsomes, Liver; Norpregnenes; Phenobarbital | 1992 |
Species difference and tissue distribution of uridine diphosphate-glucuronyltransferase activities toward E6080, 1-naphthol and 4-hydroxybiphenyl.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Biphenyl Compounds; Dogs; Enzyme Induction; Glucuronosyltransferase; Guinea Pigs; Intestinal Mucosa; Kidney; Lung; Macaca mulatta; Male; Methylcholanthrene; Microsomes; Microsomes, Liver; Naphthols; Phenobarbital; Rats; Rats, Sprague-Dawley; Species Specificity; Thiazoles; Tissue Distribution | 1992 |
Immunochemical identity of the 2,3,7,8-tetrachlorodibenzo-p-dioxin- and beta-naphthoflavone-induced cytochrome P-450 arachidonic acid epoxygenases in chick embryo liver: distinction from the omega-hydroxylase and the phenobarbital-induced epoxygenase.
Topics: Animals; Arachidonic Acid; Benzoflavones; beta-Naphthoflavone; Blotting, Western; Chick Embryo; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Immunohistochemistry; Microsomes, Liver; Mixed Function Oxygenases; Oxygenases; Phenobarbital; Polychlorinated Dibenzodioxins | 1992 |
Expression and regulation of cytochrome P-450I genes (CYP1A1 and CYP1A2) in the rat alimentary tract.
Topics: Animals; Base Sequence; Benzoflavones; beta-Naphthoflavone; Blotting, Northern; Cell Nucleus; Cytochrome P-450 Enzyme System; DNA Probes; Enzyme Induction; Esophagus; Gastric Mucosa; Gene Expression; Gene Expression Regulation, Enzymologic; Intestinal Mucosa; Liver; Male; Methylcholanthrene; Molecular Sequence Data; Mucous Membrane; Oligodeoxyribonucleotides; Phenobarbital; Polymerase Chain Reaction; Rats; Rats, Inbred F344; Reference Values; RNA, Messenger; Transcription, Genetic | 1992 |
Beta-naphthoflavone induction of a cytochrome P-450 arachidonic acid epoxygenase in chick embryo liver distinct from the aryl hydrocarbon hydroxylase and from phenobarbital-induced arachidonate epoxygenase.
Topics: Amino Acid Sequence; Animals; Arachidonic Acid; Aryl Hydrocarbon Hydroxylases; Benzoflavones; beta-Naphthoflavone; Chick Embryo; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Cytochromes b5; Enzyme Induction; Liver; Microsomes, Liver; Mixed Function Oxygenases; Molecular Sequence Data; Oxygenases; Phenobarbital; Polychlorinated Dibenzodioxins | 1992 |
Activation of 6-aminochrysene to genotoxic products by different forms of rat liver cytochrome P450 in an O-acetyltransferase-overexpressing Salmonella typhimurium strain (NM2009).
Topics: Acetyltransferases; Animals; Benzoflavones; beta-Naphthoflavone; Biotransformation; Chrysenes; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Dose-Response Relationship, Drug; Gene Expression; Male; Microsomes, Liver; Mutagenicity Tests; Pentachlorophenol; Phenobarbital; Rats; Rats, Inbred Strains; Salmonella typhimurium | 1992 |
Proton NMR study of the interaction of benzo(a)pyrene with rat liver microsomal cytochrome P-450.
Topics: Animals; Benzo(a)pyrene; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Magnetic Resonance Spectroscopy; Male; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains | 1992 |
Cytochrome P450 isozymes catalyzing 4-hydroxylation of parkinsonism-related compound 1,2,3,4-tetrahydroisoquinoline in rat liver microsomes.
Topics: Amino Acid Sequence; Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Debrisoquin; Female; Isoenzymes; Isoquinolines; Kinetics; Male; Microsomes, Liver; Mixed Function Oxygenases; Molecular Sequence Data; NADPH-Ferrihemoprotein Reductase; Naphthols; Phenobarbital; Propranolol; Rabbits; Rats; Rats, Inbred Strains; Sex Characteristics; Species Specificity; Tetrahydroisoquinolines | 1992 |
Cocaine hepatotoxicity: influence of hepatic enzyme inducing and inhibiting agents on the site of necrosis.
Topics: Alanine Transaminase; Animals; Benzoflavones; beta-Naphthoflavone; Cocaine; Liver; Male; Necrosis; Norisoprenoids; Phenobarbital; Rats; Rats, Inbred Strains; Terpenes | 1992 |
Cocaethylene hepatotoxicity in mice.
Topics: Alanine Transaminase; Animals; Benzoflavones; beta-Naphthoflavone; Cocaine; Diazinon; Glutathione; Liver; Male; Mice; Mice, Inbred ICR; Necrosis; Phenobarbital | 1992 |
Alternatives to Aroclor 1254-induced S9 in in vitro genotoxicity assays.
Topics: Aroclors; Benzoflavones; beta-Naphthoflavone; Chlorodiphenyl (54% Chlorine); Liver Extracts; Mutagenicity Tests; Phenobarbital; United Kingdom | 1992 |
N-nitrosodialkylamine dealkylation in reconstituted systems containing cytochrome P-450 purified from phenobarbital- and beta-naphthoflavone-treated rats.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Cytochromes b5; Dealkylation; In Vitro Techniques; Isoenzymes; Liver; Male; Microsomes, Liver; Nitrosamines; Phenobarbital; Rats; Rats, Inbred Strains; Substrate Specificity | 1992 |
Intralobular localization of different cytochrome P-450 form dependent monooxygenase activities in the liver of normal and inducer-treated rats.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cells, Cultured; Cytochrome P-450 Enzyme System; Enzyme Induction; Liver; Male; Oxygenases; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains | 1992 |
Covalent interactions of 1,2,3-trichloropropane with hepatic macromolecules: studies in the male F-344 rat.
Topics: Analysis of Variance; Animals; Antimetabolites; Benzoflavones; beta-Naphthoflavone; Buthionine Sulfoximine; DNA; Dose-Response Relationship, Drug; Liver; Male; Methionine Sulfoximine; Phenobarbital; Propane; Proteins; Pyridines; Rats; Rats, Inbred F344; RNA; Time Factors | 1990 |
Purification and characterization of hepatic microsomal cytochrome P-450 in phenobarbital- and beta-naphthoflavone-treated pigs.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Chromatography, Ion Exchange; Cross Reactions; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Female; Immunodiffusion; Isoenzymes; Male; Microsomes, Liver; Molecular Weight; Organ Size; Phenobarbital; Rats; Rats, Inbred Strains; Swine | 1991 |
Influence of inducers of cytochrome P-450 on dealkylation of 7-alkoxycoumarins.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Coumarins; Cytochrome P-450 Enzyme System; Dealkylation; Enzyme Induction; Male; Phenobarbital; Rats | 1991 |
Effect of nifedipine on the enzyme-inducing activity of phenobarbital and beta-naphthoflavone.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Cytochromes b5; Enzyme Induction; Hexobarbital; Liver; Male; Mixed Function Oxygenases; Nifedipine; Phenobarbital; Rats; Rats, Inbred Strains; Sleep | 1991 |
Comparison of cytochrome P450 isoenzyme profiles in rat liver and hepatocyte cultures. The effects of model inducers on apoproteins and biotransformation activities.
Topics: Animals; Apoproteins; Aryl Hydrocarbon Hydroxylases; Benzoflavones; beta-Naphthoflavone; Biotransformation; Blotting, Western; Cells, Cultured; Clofibrate; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Dexamethasone; Enzyme Induction; Isoenzymes; Isoniazid; Liver; Male; Microsomes, Liver; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred Strains; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases | 1991 |
[The mixed-function oxidase activity in male rats with a pancreatectomy].
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Diabetes Mellitus, Experimental; Enzyme Induction; Male; Microsomes, Liver; Mixed Function Oxygenases; Pancreas; Pancreatectomy; Phenobarbital; Rats; Rats, Inbred Strains; Time Factors | 1991 |
Immobilized artificial membrane chromatography: rapid purification of functional membrane proteins.
Topics: Adrenal Glands; Animals; Benzoflavones; beta-Naphthoflavone; Chromatography; Cytochrome P-450 Enzyme System; Detergents; Kidney; Male; Membrane Proteins; Membranes, Artificial; Microsomes; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Osmolar Concentration; Phenobarbital; Rats; Rats, Inbred Strains | 1991 |
Tissue-specific induction of the carcinogen inducible cytochrome P450 isoform, P450IAI, in colonic epithelium.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Benzoflavones; beta-Naphthoflavone; Blotting, Western; Colon; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Enzyme Induction; Epithelium; Intestinal Mucosa; Intestine, Small; Liver; Male; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred Strains | 1991 |
Effects of surfactants on the contents of metallothionein, heme and hemoproteins and on the activities of heme oxygenase and drug-metabolizing enzymes in rats pretreated with phenobarbital or beta-naphthoflavone.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Heme; Heme Oxygenase (Decyclizing); Hemeproteins; Liver; Male; Metallothionein; Mixed Function Oxygenases; Phenobarbital; Proteins; Rats; Rats, Inbred Strains; Surface-Active Agents; Zinc | 1991 |
DNA fragmentation by 2-nitropropane in rat tissues, and effects of the modulation of biotransformation processes.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Biotransformation; Bone Marrow; Brain; Carcinogens; Cytochrome P-450 Enzyme System; DNA Damage; Glutathione; Kidney; Liver; Lung; Male; Nitroparaffins; Organ Specificity; Phenobarbital; Propane; Rats; Rats, Inbred Strains | 1991 |
Mutagenic evaluation of trichlorfon using different assay methods with Salmonella typhimurium.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Biotransformation; Microsomes, Liver; Mutagenicity Tests; Mutation; Phenobarbital; Rats; Rats, Inbred Strains; Salmonella typhimurium; Trichlorfon | 1991 |
Nicotine metabolism in isolated perfused lung and liver of phenobarbital- and benzoflavone-treated rats.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Drug Interactions; In Vitro Techniques; Liver; Lung; Male; Nicotine; Perfusion; Phenobarbital; Rats; Rats, Inbred Strains | 1991 |
Hepatotoxicity of eugenol in mice depleted of glutathione by treatment with DL-buthionine sulfoximine.
Topics: Alanine Transaminase; Animals; Antimetabolites; Benzoflavones; beta-Naphthoflavone; Buthionine Sulfoximine; Chemical and Drug Induced Liver Injury; Eugenol; Glutathione; Liver; Liver Circulation; Male; Methionine Sulfoximine; Mice; Mice, Inbred Strains; Organ Size; Phenobarbital | 1991 |
Bioactivation of 8-methoxypsoralen and irreversible inactivation of cytochrome P-450 in mouse liver microsomes: modification by monoclonal antibodies, inhibition of drug metabolism and distribution of covalent adducts.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Antibodies, Monoclonal; Benzoflavones; beta-Naphthoflavone; Binding Sites; Cells, Cultured; Cysteine; Cytochrome P-450 Enzyme System; Flavonoids; Lysine; Male; Methoxsalen; Mice; Microsomes, Liver; Phenobarbital | 1990 |
Effects of phenobarbital and beta-naphthoflavone on the in vivo toxicity and in vitro metabolism of aflatoxin in an aflatoxin-resistant and control line of chickens.
Topics: Aflatoxins; Animals; Benzoflavones; beta-Naphthoflavone; Chickens; Chromatography, High Pressure Liquid; Drug Resistance; Female; Glucuronosyltransferase; Glutathione Transferase; Liver; Male; Microsomes, Liver; Mycotoxicosis; Organ Size; Phenobarbital | 1990 |
Studies of cytotoxicity and metabolic competence with the rat intestinal cell line IEC-17.
Topics: 7-Alkoxycoumarin O-Dealkylase; 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzoflavones; beta-Naphthoflavone; Cell Differentiation; Cell Line; Cell Survival; Cyclophosphamide; Epithelial Cells; Intestinal Mucosa; Intestines; Phenobarbital; Rats; Xenobiotics | 1990 |
Cytochrome P-450 mediated biotransformation of organic nitrates.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Biotransformation; Chromatography, Gas; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; In Vitro Techniques; Isosorbide Dinitrate; Kinetics; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Nitrates; Nitroglycerin; Oxygen; Phenobarbital; Rats; Rats, Inbred Strains; Stereoisomerism | 1990 |
Inhibition of cholinesterases by DRP and induction of organophosphate-detoxicating enzymes in rats.
Topics: Acetylcholinesterase; Animals; Aryldialkylphosphatase; Benzoflavones; beta-Naphthoflavone; Carboxylic Ester Hydrolases; Cholinesterase Inhibitors; Cholinesterases; Cytochrome P-450 Enzyme System; Enzyme Induction; Esterases; Glutathione Transferase; Hydrolases; Inactivation, Metabolic; Isoflurophate; Male; Microsomes; Microsomes, Liver; Phenobarbital; Phosphoric Monoester Hydrolases; Phosphoric Triester Hydrolases; Rats; Rats, Inbred Strains | 1990 |
Purification and characterization of cytochrome P450 isozymes from beta-naphthoflavone-induced adult hen liver.
Topics: Amino Acid Sequence; Animals; Benzoflavones; beta-Naphthoflavone; Chickens; Chromatography; Chromatography, Affinity; Chromatography, DEAE-Cellulose; Chromatography, Ion Exchange; Cytochrome P-450 Enzyme System; Cytochromes b5; Durapatite; Enzyme Induction; Female; Hydroxyapatites; Isoenzymes; Microsomes, Liver; Molecular Sequence Data; Molecular Weight; Peptide Fragments; Phenobarbital; Substrate Specificity | 1990 |
Hepatic catecholestrogen synthases: differential effect of sex, inducers of cytochromes P-450 and of antibody to the glucocorticoid inducible cytochrome P-450 on NADPH-dependent estrogen-2-hydroxylase and on organic hydroperoxide-dependent estrogen-2/4-hy
Topics: Animals; Antibodies; Benzoflavones; beta-Naphthoflavone; Clofibrate; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Estradiol; Estrogens, Catechol; Female; Isoniazid; Kinetics; Male; Microsomes, Liver; NADP; Phenobarbital; Rats; Rats, Inbred Strains; Sex Factors | 1990 |
Irreversible binding of heme to microsomal protein during inactivation of cytochrome P450 by 4-alkyl analogues of 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Dexamethasone; Dicarbethoxydihydrocollidine; Enzyme Induction; Heme; Isoenzymes; Male; Microsomes, Liver; NADP; Phenobarbital; Proteins; Rats; Rats, Inbred Strains | 1990 |
N-aralkylated derivatives of 1-aminobenzotriazole as isozyme-selective, mechanism-based inhibitors of guinea pig hepatic cytochrome P-450 dependent monooxygenase activity.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Female; Guinea Pigs; Isoenzymes; Kinetics; Liver; Male; Microsomes, Liver; Oxidoreductases; Oxidoreductases, N-Demethylating; Phenobarbital; Triazoles | 1990 |
BCNU-induced quantitative and qualitative changes in hepatic cytochrome P-450 can be correlated with cholestasis.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Carmustine; Cholestasis; Cytochrome P-450 Enzyme System; Electrophoresis, Disc; Endoplasmic Reticulum; Liver; Male; Microsomes, Liver; Mixed Function Oxygenases; Molecular Weight; Organ Size; Phenobarbital; Rats; Rats, Inbred Strains | 1990 |
Time course of inhibition of acetylcholinesterase and aliesterases following parathion and paraoxon exposures in rats.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Brain; Carboxylesterase; Carboxylic Ester Hydrolases; Cholinesterase Inhibitors; Cytochrome P-450 Enzyme System; Environmental Exposure; Enzyme Induction; Female; Liver; Paraoxon; Parathion; Phenobarbital; Piperonyl Butoxide; Poisoning; Rats; Rats, Inbred Strains; Time Factors | 1990 |
Formation of cytotoxic metabolites from phenytoin, imipramine, desipramine, amitriptyline and mianserin by mouse and human hepatic microsomes.
Topics: 7-Alkoxycoumarin O-Dealkylase; Amitriptyline; Animals; Benzoflavones; beta-Naphthoflavone; Biotransformation; Desipramine; Dibenzoxazepines; Enzyme Induction; Humans; Imipramine; Injections, Intraperitoneal; Male; Mianserin; Mice; Mice, Inbred CBA; Microsomes, Liver; Phenobarbital; Phenytoin | 1990 |
Cytochrome P-450 enzyme-specific control of the regio- and enantiofacial selectivity of the microsomal arachidonic acid epoxygenase.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Male; Microsomes, Liver; Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains; Stereoisomerism; Substrate Specificity | 1990 |
Hepatic microsomal warfarin metabolism in warfarin-resistant and susceptible mouse strains: influence of pretreatment with cytochrome P-450 inducers.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Clofibrate; Cytochrome P-450 Enzyme System; Drug Resistance; Enzyme Induction; Female; Male; Mice; Microsomes, Liver; Phenobarbital; Sex Factors; Species Specificity; Stereoisomerism; Warfarin | 1990 |
The in vivo induction of rat hepatic cytochrome P450-dependent enzyme activities and their maintenance in culture.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; beta-Naphthoflavone; Cells, Cultured; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Isoniazid; Liver; Male; Mixed Function Oxygenases; Oxidoreductases; Oxidoreductases, N-Demethylating; Phenobarbital; Rats; Rats, Inbred Strains | 1990 |
The effects of selective cytochrome P-450 inducing agents on trimethadione metabolism as an indicator of hepatic drug-oxidizing capacity in rats.
Topics: Animals; Aroclors; Benzoflavones; beta-Naphthoflavone; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Liver; Male; Methylcholanthrene; Oxazoles; Phenobarbital; Rats; Rats, Inbred Strains; Safrole; Trimethadione | 1990 |
Influence of age, phenobarbital and beta-naphthoflavone on hepatic microsomal lipid peroxidation in rats.
Topics: Aging; Animals; Animals, Newborn; Benzoflavones; beta-Naphthoflavone; Flavonoids; Lipid Peroxidation; Male; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains | 1990 |
Effects of 4-alkyl analogues of 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine on hepatic cytochrome P-450 heme, apoproteins, and catalytic activities following in vivo administration to rats.
Topics: Animals; Apoproteins; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Dexamethasone; Dicarbethoxydihydrocollidine; Dihydropyridines; Enzyme Induction; Heme; Immunologic Techniques; Male; Microsomes, Liver; Phenobarbital; Rats; Structure-Activity Relationship; Time Factors | 1990 |
Distribution and induction sites of phenobarbital- and 3-methylcholanthrene-inducible cytochromes P-450 in murine liver: immunohistochemical localization with monoclonal antibodies.
Topics: Animals; Antibodies, Monoclonal; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Enzyme Activation; Epitopes; Immunoenzyme Techniques; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Phenobarbital | 1988 |
Effects of bromocriptine on hepatic cytochrome P-450 monooxygenase system.
Topics: Aminopyrine N-Demethylase; Animals; Benzoflavones; beta-Naphthoflavone; Bromocriptine; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Male; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred Strains | 1989 |
Aroclor-1254-induced rat-liver S9 causes chromosomal aberrations in CHO cells but not human lymphocytes: a role for active oxygen?
Topics: Animals; Aroclors; Benzoflavones; beta-Naphthoflavone; Biotransformation; Catalase; Cell Line; Chromosome Aberrations; Cricetinae; Cricetulus; Female; Humans; Liver; Lymphocytes; Male; Mutagenicity Tests; Oxygen; Phenobarbital; Polychlorinated Biphenyls; Rats; Rats, Inbred Strains; Vitamin E | 1989 |
Further consideration of phenobarbital effects on cytochrome P-450 activity in the killifish, Fundulus heteroclitus.
Topics: Animals; Antibodies, Monoclonal; Benzoflavones; beta-Naphthoflavone; Blotting, Western; Cyprinodontiformes; Cytochrome P-450 Enzyme System; Female; Killifishes; Male; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital | 1989 |
Effects of a series of 4-alkyl analogues of 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine on the major inducible cytochrome P-450 isozymes of rat liver.
Topics: Animals; Antibodies, Monoclonal; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Dexamethasone; Dicarbethoxydihydrocollidine; Dihydropyridines; Enzyme Induction; Heme; Isoenzymes; Male; NADP; Phenobarbital; Rats; Rats, Inbred Strains | 1989 |
Activation of 8-methoxypsoralen by cytochrome P-450. Enzyme kinetics of covalent binding and influence of inhibitors and inducers of drug metabolism.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Biotransformation; Cytochrome P-450 Enzyme System; Kinetics; Methoxsalen; Microsomes, Liver; Phenobarbital; Protein Binding; Pyridines; Rats; Rats, Inbred Strains | 1989 |
In vitro interaction of rat liver cytochromes P-450 with erythromycin, oleandomycin and erythralosamine derivatives. Importance of structural factors.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome b Group; Cytochrome P-450 Enzyme System; Cytochromes b5; Erythromycin; Kinetics; Magnetic Resonance Spectroscopy; Male; Microsomes, Liver; Oleandomycin; Phenobarbital; Protein Binding; Rats; Rats, Inbred Strains; Reference Values; Structure-Activity Relationship | 1989 |
Induced hepatocytes as a metabolic activation system for the mouse-lymphoma assay.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Biotransformation; Cells, Cultured; Enzyme Activation; In Vitro Techniques; Liver; Lymphoma; Mice; Mutagenicity Tests; Mutagens; Phenobarbital; Thymidine Kinase | 1989 |
4-(2-amino-1-methylimidazo[4,5-b]pyrid-6-yl)phenyl sulfate--a major metabolite of the food mutagen 2-amino-1-methyl-6- phenylimidazo[4,5-b]pyridine (PhIP) in the rat.
Topics: Animals; Aroclors; Benzoflavones; beta-Naphthoflavone; Biotransformation; Cells, Cultured; Chlorodiphenyl (54% Chlorine); Chromatography, High Pressure Liquid; Imidazoles; Liver; Magnetic Resonance Spectroscopy; Microsomes, Liver; Mutagens; Phenobarbital; Pyridines; Rats; Sulfates; Sulfur Radioisotopes | 1989 |
Lack of inducibility of brain monooxygenase activities including parathion desulfuration.
Topics: Aminopyrine N-Demethylase; Animals; Benzoflavones; beta-Naphthoflavone; Biotransformation; Brain; Enzyme Induction; Female; In Vitro Techniques; Male; Mixed Function Oxygenases; Parathion; Phenobarbital; Rats; Rats, Inbred Strains; Sulfur | 1989 |
Induction of liver microsomal cytochrome P-450 isozymes by 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinoline carboxamide.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Blotting, Western; Cytochrome P-450 Enzyme System; Cytochromes b5; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Female; Immunochemistry; Isoenzymes; Isoquinolines; Male; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains | 1989 |
Induction of cytochrome P-450 in cultured rat hepatocytes. The heterogeneous localization of specific isoenzymes using immunocytochemistry.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cells, Cultured; Clofibric Acid; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Activation; Isoenzymes; Isomerism; Liver; Male; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Safrole | 1989 |
Protection of rat from oxygen toxicity by inducers of cytochrome P-450 system.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Hydrogen Peroxide; Lung; Male; Malondialdehyde; Methylcholanthrene; Microsomes; Oxygen; Phenobarbital; Pulmonary Edema; Random Allocation; Rats; Rats, Inbred Strains; Superoxides | 1988 |
Alteration of methylcholanthrene-mediated suppression of cutaneous delayed hypersensitivity by benzoflavone treatment of C57BL/6J mice.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dinitrofluorobenzene; Dose-Response Relationship, Drug; Drug Hypersensitivity; Enzyme Induction; Female; Flavonoids; Hypersensitivity, Delayed; Immunosuppressive Agents; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Phenobarbital; Polycyclic Compounds; Receptors, Aryl Hydrocarbon; Receptors, Drug | 1988 |
A comparative study of the hepatotoxicity of monochlorobenzene in the rainbow trout (Salmo gairdnerii) and the Sprague-Dawley rat.
Topics: Alanine Transaminase; Animals; Benzoflavones; beta-Naphthoflavone; Chlorobenzenes; Glutathione; Liver; Male; Maleates; Necrosis; Neurons; Phenobarbital; Protein Binding; Rats; Rats, Inbred Strains; Salmonidae; Species Specificity; Time Factors; Trout | 1985 |
Primary cultures of adult rat hepatocytes--a model for the toxicity of histamine H2-receptor antagonists.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cells, Cultured; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Energy Metabolism; Histamine H2 Antagonists; Imidazoles; L-Lactate Dehydrogenase; Liver; Male; Oxygen Consumption; Phenobarbital; Protein Biosynthesis; Rats; Rats, Inbred Strains | 1985 |
Effects of varying inducer type and dose on hepatic monooxygenase activities in the mountain vole Microtus montanus.
Topics: Aniline Hydroxylase; Animals; Aroclors; Arvicolinae; Aryl Hydrocarbon Hydroxylases; Benzoflavones; beta-Naphthoflavone; Chlorodiphenyl (54% Chlorine); Female; Flavonoids; Kinetics; Microsomes, Liver; Nitroanisole O-Demethylase; Oxidoreductases; Phenobarbital; Polychlorinated Biphenyls | 1986 |
Effects of inducer pretreatment on liver function and morphology in the mountain vole Microtus montanus.
Topics: Alanine Transaminase; Animals; Aroclors; Arvicolinae; Benzoflavones; beta-Naphthoflavone; Carboxylic Ester Hydrolases; Chlorodiphenyl (54% Chlorine); Flavonoids; Liver; Phenobarbital; Polychlorinated Biphenyls | 1987 |
Heme may not be a positive regulator of cytochrome-P450 gene expression.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Benzoflavones; beta-Naphthoflavone; Clofibrate; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Gene Expression Regulation; Genes; Heme; Humans; Liver; Male; Phenobarbital; Rats; Rats, Inbred Strains; Reference Values; RNA, Messenger; Transcription, Genetic | 1989 |
Stereoselectivity of styrene oxidation in microsomes and in purified cytochrome P-450 enzymes from rat liver.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Glutathione; Liver; Male; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Rats; Rats, Inbred Strains; Stereoisomerism; Styrene; Styrenes | 1989 |
Influence of medium composition on 7-alkoxycoumarin O-dealkylase activities of rat hepatocytes in primary maintenance culture.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Benzoflavones; beta-Naphthoflavone; Cells, Cultured; Culture Media; Dexamethasone; Liver; Male; Niacinamide; Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains; Umbelliferones | 1988 |
Mixed-function oxidase system induction and propylene hepatotoxicity.
Topics: Alkenes; Aminopyrine N-Demethylase; Analysis of Variance; Aniline Hydroxylase; Animals; Aroclors; Atmosphere Exposure Chambers; Benzoflavones; beta-Naphthoflavone; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Induction; Glucose-6-Phosphatase; Male; Microsomes, Liver; Mixed Function Oxygenases; Organ Size; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains | 1985 |
Induction of renal and hepatic mixed function oxidases in the hamster and guinea pig.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cricetinae; Cytochrome P-450 Enzyme System; Electron Transport; Enzyme Induction; Flavonoids; Guinea Pigs; Kidney; Male; Mesocricetus; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Organ Size; Phenobarbital; Polybrominated Biphenyls; Species Specificity | 1986 |
Isolation of S9 fractions from mouse and rat with increased enzyme activities after repeated administration of cytochrome P-450 and P-448 inducers.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; Enzyme Induction; Female; Flavonoids; Liver; Male; Mice; Mice, Inbred Strains; Mixed Function Oxygenases; Mutagenicity Tests; Phenobarbital; Rats; Rats, Inbred Strains; Saccharomyces cerevisiae; Sex Factors; Subcellular Fractions | 1988 |
[Cytochrome P-450 isoforms in the liver of rats treated with phenobarbital, 3-methylcholanthrene and Aroclor 1254 studied by monoclonal antibodies].
Topics: Animals; Antibodies, Monoclonal; Aroclors; Benzoflavones; beta-Naphthoflavone; Chlorodiphenyl (54% Chlorine); Clone Cells; Cytochrome P-450 Enzyme System; Imidazoles; Immunization; Isoenzymes; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred BALB C; Phenobarbital; Polychlorinated Biphenyls; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains | 1986 |
[Protection of the pulmonary toxic effects of normobaric oxygen by inducers of cytochrome P450-linked monooxygenases].
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Enzyme Induction; Methylcholanthrene; Oxygen; Oxygenases; Phenobarbital; Pulmonary Edema; Rats; Rats, Inbred Strains | 1986 |
Effect of phenobarbital and beta-naphthoflavone on oxidative metabolism of N,N-dimethyl-4-aminoazobenzene by regenerating rat-liver microsomes and its response to sulphydryl compounds.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Enzyme Induction; Flavonoids; Hepatectomy; Kinetics; Liver Regeneration; Male; Microsomes, Liver; Oxidation-Reduction; p-Aminoazobenzene; p-Dimethylaminoazobenzene; Phenobarbital; Rats; Rats, Inbred Strains; Sulfhydryl Compounds | 1986 |
Stability of drug metabolizing enzymes during the incubation conditions of the liver microsomal assay with non-induced and induced mouse liver S-9 fractions.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Enzyme Induction; Epoxide Hydrolases; Female; Glutathione Transferase; Lipid Peroxides; Male; Mice; Microsomes, Liver; Mutagenicity Tests; NADPH-Ferrihemoprotein Reductase; Pharmaceutical Preparations; Phenobarbital | 1987 |
Distributions and properties of cytochromes P-450 and cytochrome P-450 reductase from rat colon mucosal cells.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Colon; Cytochrome P-450 Enzyme System; Female; Intestinal Mucosa; Kinetics; Microsomes; Molecular Weight; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Rats; Rats, Inbred Strains | 1987 |
The use of single sample clearance estimates to probe hepatic drug metabolism in rats. II.
Topics: Animals; Antipyrine; Benzoflavones; beta-Naphthoflavone; Clofibrate; Drug Interactions; Liver; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Phenobarbital; Rats; Rats, Inbred Strains; Safrole; Theophylline; Valproic Acid; Warfarin | 1988 |
Induction and quail liver diamine oxidase (histaminase). Part II: Different responses to the inducers.
Topics: Amine Oxidase (Copper-Containing); Animals; Aroclors; Benzoflavones; beta-Naphthoflavone; Chlorodiphenyl (54% Chlorine); Clofibrate; Enzyme Induction; Histamine; In Vitro Techniques; Microsomes, Liver; Phenobarbital; Putrescine; Quail; Substrate Specificity | 1988 |
Olfactory cytochrome P-450. Studies with suicide substrates of the haemoprotein.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Benzoflavones; beta-Naphthoflavone; Cricetinae; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Dicarbethoxydihydrocollidine; Epithelium; Liver; Male; Mesocricetus; NADH Dehydrogenase; Olfactory Mucosa; Oxidoreductases; Oxygenases; Peroxidases; Phenobarbital | 1988 |
Induction of cytochrome P-450 mRNA in rainbow trout: in vitro translation and immunodetection.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Immunosorbent Techniques; Isoenzymes; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Protein Biosynthesis; Reference Values; RNA, Messenger; Salmonidae; Time Factors; Trout | 1988 |
Hepatic microsomal metabolism of androst-4-ene-3,17-dione: relative importance of ring hydroxylation and aromatization in control and induced rat liver.
Topics: Androstenedione; Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Estradiol; Estrone; Hydroxylation; Male; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Reference Values | 1988 |
Genetic differences in response to pulmonary cytochrome P-450 inducers and oxygen toxicity.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Enzyme Induction; Flavonoids; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Microsomes, Liver; Oxygen; Phenobarbital; Pulmonary Edema; Species Specificity | 1988 |
Effect of microsomal enzyme inducers on the urinary excretion pattern of mutagenic metabolites of the carcinogen 2,4-toluenediamine.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Biotransformation; Carcinogens; Male; Methylcholanthrene; Microsomes, Liver; Mutagenicity Tests; Mutagens; Phenobarbital; Phenylenediamines; Rats; Rats, Inbred F344 | 1986 |
Induction of hepatic microsomal mixed function oxidase system by ethylenethiourea in mice.
Topics: Aniline Hydroxylase; Animals; Benzoflavones; beta-Naphthoflavone; Dactinomycin; Enzyme Induction; Ethylenethiourea; Imidazoles; Male; Mice; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital | 1986 |
Induction of cytochrome P-450 mediated mono-oxygenase reactions and conjugation activities in freshwater crayfish (Astacus astacus).
Topics: Animals; Aroclors; Astacoidea; Benzoflavones; beta-Naphthoflavone; Biotransformation; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Liver; Male; Oxygenases; Pancreas; Phenobarbital | 1986 |
Species characteristics of the hepatic xenobiotic and steroid biotransformation systems of two teleost fish, Atlantic cod (Gadus morhua) and rainbow trout (Salmo gairdneri).
Topics: 7-Alkoxycoumarin O-Dealkylase; Androstenedione; Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; beta-Naphthoflavone; Biotransformation; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Enzyme Induction; Ethylmorphine-N-Demethylase; Female; Fishes; Liver; Male; Microsomes, Liver; Oxidoreductases; Oxygenases; Phenobarbital; Salmonidae; Species Specificity; Steroids; Trout | 1987 |
Effect of beta-naphthoflavone on mitochondrial supply of reducing equivalents for monooxygenation in periportal and pericentral regions of the liver lobule.
Topics: 6-Aminonicotinamide; 7-Alkoxycoumarin O-Dealkylase; Ammonia; Animals; Benzoflavones; beta-Naphthoflavone; Corn Oil; Cyanides; Cytochrome P-450 Enzyme System; Fasting; Flavonoids; Liver; Mitochondria; Oxidation-Reduction; Oxygenases; Pentose Phosphate Pathway; Phenobarbital; Rats | 1987 |
Immunocytochemical localization of cytochrome P-450 in hepatic and extra-hepatic tissues of the rat with a monoclonal antibody against cytochrome P-450 c.
Topics: Adrenal Glands; Animals; Antibodies, Monoclonal; Benzoflavones; beta-Naphthoflavone; Clofibrate; Cytochrome P-450 Enzyme System; Enzyme Induction; Histocytochemistry; Immunoenzyme Techniques; Intestine, Small; Isoenzymes; Kidney; Liver; Lung; Male; Mice; Olfactory Mucosa; Phenobarbital; Rats; Rats, Inbred Strains; Testis | 1986 |
Polycyclic aromatic hydrocarbons cause hepatic porphyria in iron-loaded C57BL/10 mice: comparison of uroporphyrinogen decarboxylase inhibition with induction of alkoxyphenoxazone dealkylations.
Topics: Animals; Benz(a)Anthracenes; Benzo(a)pyrene; Benzoflavones; beta-Naphthoflavone; Carboxy-Lyases; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Enzyme Induction; Iron; Male; Mice; Mice, Inbred C57BL; Oxidoreductases; Phenobarbital; Polycyclic Compounds; Porphyrias; Safrole; Uroporphyrinogen Decarboxylase | 1987 |
Interaction of induction, ontogenetic development and liver regeneration on the monooxygenase level.
Topics: Age Factors; Aging; Animals; Benzoflavones; beta-Naphthoflavone; Body Weight; Coumarins; Cytochrome P-450 Enzyme System; Enzyme Induction; Ethylmorphine; Hepatectomy; Liver; Liver Regeneration; Male; Phenobarbital; Rats; Rats, Inbred Strains | 1987 |
Metabolism of caffeine to 6-amino-5-[N-methylformylamino]-1,3-dimethyluracil in the isolated, perfused liver from control or phenobarbital-, beta-naphthoflavone- and 3-methylcholanthrene-pretreated rats.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Biotransformation; Caffeine; Chromatography, High Pressure Liquid; Drug Interactions; Kinetics; Liver; Male; Methylcholanthrene; Phenobarbital; Rats; Uracil | 1987 |
Differential effects of phenobarbital on ester and ether glucuronidation of diflunisal in rats.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Bile; Diflunisal; Esters; Ethers; Glucuronates; Hydrogen-Ion Concentration; Male; Metabolic Clearance Rate; Methylcholanthrene; Phenobarbital; Protein Binding; Rats; Rats, Inbred Strains; Salicylates | 1987 |
Eightfold induction of nicotine elimination in perfused rat liver by pretreatment with phenobarbital.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; Enzyme Induction; Kinetics; Liver; Male; Nicotine; Phenobarbital; Rats; Rats, Inbred Strains | 1987 |
Expression of five forms of microsomal cytochrome P-450 in primary cultures of rabbit hepatocytes treated with various classes of inducers.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cells, Cultured; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Female; Male; Microsomes, Liver; Phenobarbital; Rabbits; Rifampin; RNA, Messenger | 1987 |
Characterization of the cytochrome P-450 monooxygenase system of hamster liver microsomes. Effects of prior treatment with ethanol and other xenobiotics.
Topics: Animals; Benzoflavones; Benzphetamine; beta-Naphthoflavone; Cricetinae; Cytochrome P-450 Enzyme System; Ethanol; Isoniazid; Male; Mesocricetus; Microsomes, Liver; Molecular Weight; Oxidation-Reduction; Oxygenases; Phenobarbital; Species Specificity | 1987 |
Effect of change of hepatic drug-metabolizing activity on plasma concentrations of major metabolites of the new sleep inducer 450191-S, a 1H-1,2,4-triazolyl benzophenone derivative.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Chromatography, High Pressure Liquid; Enzyme Induction; Hypnotics and Sedatives; Liver; Male; Mixed Function Oxygenases; Pharmaceutical Preparations; Phenobarbital; Rats; Rats, Inbred Strains; Time Factors; Triazoles | 1987 |
[Effect of tritoqualine (TRQ) on bile secretion in rats].
Topics: Administration, Oral; Alkaloids; Animals; Benzoflavones; Benzofurans; beta-Naphthoflavone; Bile; Cholagogues and Choleretics; Injections, Intravenous; Isoquinolines; Liver; Male; Phenobarbital; Rats; Rats, Inbred Strains; Tetrahydroisoquinolines | 1986 |
In vitro studies on the metabolism and covalent binding of [14C]1,1-dichloroethylene by mouse liver, kidney and lung.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Carbon Monoxide; Cytochrome P-450 Enzyme System; Dichloroethylenes; Enzyme Induction; Glutathione; Hot Temperature; Hydrocarbons, Chlorinated; In Vitro Techniques; Kidney; Liver; Lung; Methylcholanthrene; Mice; Mice, Inbred C57BL; NADP; Phenobarbital; Piperonyl Butoxide; Pregnenolone Carbonitrile; Proadifen; Subcellular Fractions | 1986 |
Indomethacin metabolism in liver microsomes during postnatal development in the rat.
Topics: Aging; Animals; Benzoflavones; beta-Naphthoflavone; Chromatography, High Pressure Liquid; Enzyme Induction; In Vitro Techniques; Indomethacin; Kinetics; Male; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains | 1986 |
Aging modifies the expression of hepatic microsomal cytochromes P-450 after pretreatment of rats with beta-naphthoflavone or phenobarbital.
Topics: Aging; Animals; Benzoflavones; beta-Naphthoflavone; Biotransformation; Cytochrome P-450 Enzyme System; Enzyme Induction; Flavonoids; Isoenzymes; Male; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains | 1986 |
Isomeric composition of N-alkylated protoporphyrins produced by substituted dihydropyridines in vivo and in vitro.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Dihydropyridines; In Vitro Techniques; Kinetics; Mice; Mice, Inbred Strains; Microsomes, Liver; Phenobarbital; Porphyrins; Protoporphyrins; Pyridines; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1986 |
Comparison of the metabolism of benzene and its metabolite phenol in rat liver microsomes.
Topics: Animals; Benzene; Benzoflavones; beta-Naphthoflavone; Biotransformation; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Kinetics; Male; Microsomes, Liver; Phenobarbital; Phenol; Phenols; Rats; Rats, Inbred Strains; Spectrophotometry | 1986 |
Metabolism and carcinogenicity of nitrotoluenes.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Bile; Biotransformation; Carcinogens; Female; Gallbladder; Liver; Male; Microsomes, Liver; Phenobarbital; Rats; Sex Factors; Toluene | 1986 |
Biological reactive intermediates of pyrrolizidine alkaloids.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Chromatography, High Pressure Liquid; Male; Mass Spectrometry; Microsomes, Liver; Phenobarbital; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1986 |
Induction of a high spin form of microsomal cytochrome P-448 in rat liver by 4-aminoazobenzene derivatives.
Topics: Animals; Azo Compounds; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 CYP1A2; Cytochromes; Dose-Response Relationship, Drug; Male; Methylcholanthrene; Microsomes, Liver; p-Aminoazobenzene; Phenobarbital; Polychlorinated Dibenzodioxins; Rats; Rats, Inbred Strains; Safrole | 1986 |
3-(Trifluoromethyl)-3-(m-[125I]iodophenyl)diazirine photolabels a substrate-binding site of rat hepatic cytochrome P-450 form PB-4.
Topics: Animals; Azirines; Benzoflavones; beta-Naphthoflavone; Binding Sites; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Iodine Radioisotopes; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Photochemistry; Rats | 1986 |
Chemical modulation of 3-methylindole toxicosis in mice: effect on bronchiolar and olfactory mucosal injury.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Bronchi; Epithelium; Female; Flavonoids; Glutathione; Indoles; Male; Maleates; Mice; Mice, Inbred C57BL; Mixed Function Oxygenases; Nasal Mucosa; Phenobarbital; Piperonyl Butoxide; Proadifen; Sex Factors; Skatole | 1986 |
o,p'-DDD in the mouse lung: selective uptake, covalent binding and effect on drug metabolism.
Topics: Adipose Tissue; Adrenal Glands; Aminopyrine; Animals; Autoradiography; Benzoflavones; beta-Naphthoflavone; DDT; Dose-Response Relationship, Drug; Isomerism; Liver; Lung; Maleates; Metyrapone; Mice; Mice, Inbred C57BL; Mitotane; Phenobarbital; Pulmonary Alveoli | 1986 |
N-alkylation of exogenous haem analogues caused by drugs in isolated hepatocytes. Structural isomerism and chirality of the resulting porphyrins.
Topics: Acetamides; Allylisopropylacetamide; Animals; Benzoflavones; beta-Naphthoflavone; Chromatography, High Pressure Liquid; Deuteroporphyrins; Dicarbethoxydihydrocollidine; In Vitro Techniques; Liver; Male; Mesoporphyrins; Phenobarbital; Porphyrins; Pyridines; Rats; Rats, Inbred Strains; Stereoisomerism | 1986 |
Oxidative biotransformation in primary cultures of chick embryo hepatocytes: induction of cytochrome P-450 and the metabolism of benzo(a)pyrene.
Topics: Animals; Aroclors; Benzo(a)pyrene; Benzoflavones; beta-Naphthoflavone; Cells, Cultured; Chick Embryo; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Enzyme Induction; Liver; Oxidoreductases; Phenobarbital; Porphyrins | 1986 |
Increased response of cytochrome P-450 dependent biotransformation reactions in rat liver to repeated administration of inducers.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; beta-Naphthoflavone; Biotransformation; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Enzyme Induction; Flavonoids; Liver; Male; Methylcholanthrene; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred Strains | 1985 |
Cytochrome P-450 and monooxygenase activity in hepatic microsomes from N-phenylimidazole-treated rats.
Topics: 7-Alkoxycoumarin O-Dealkylase; Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Benzoflavones; Benzopyrene Hydroxylase; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Enzyme Induction; Imidazoles; Male; Microsomes, Liver; Mixed Function Oxygenases; Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains; Spectrophotometry | 1985 |
Influence of temperature on basal and induced hepatic monooxygenase activity in rats of different ages.
Topics: 7-Alkoxycoumarin O-Dealkylase; Age Factors; Animals; Benzoflavones; beta-Naphthoflavone; Ethylmorphine-N-Demethylase; Female; In Vitro Techniques; Liver; Male; Oxidoreductases, N-Demethylating; Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains; Temperature; Thermodynamics | 1985 |
Oxidation and glucuronidation of valproic acid in male rats--influence of phenobarbital, 3-methylcholanthrene, beta-naphthoflavone and clofibrate.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Clofibrate; Enzyme Induction; Flavonoids; Glucuronates; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Rats; Rats, Inbred Strains; Valproic Acid | 1985 |
Immunohistochemical localization of cytochrome P-450 and reduced nicotinamide adenine dinucleotide phosphate:cytochrome P-450 reductase in the rat ventral prostate.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Immunoenzyme Techniques; Male; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Prostate; Rats; Rats, Inbred Strains | 1985 |
Microsomal metabolism of the carcinogen, N-2-fluorenyl-acetamide, by the mammary gland and liver of female rats. II. Glucuronidation of ring- and N-hydroxylated metabolites of N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Animals; Benzoflavones; beta-Naphthoflavone; Carbon Radioisotopes; Female; Glucuronates; Glucuronosyltransferase; Hydroxylation; In Vitro Techniques; Lactation; Mammary Glands, Animal; Microsomes; Microsomes, Liver; Nitrophenols; Phenobarbital; Pregnancy; Rats; Rats, Inbred Strains | 1985 |
Activation and inactivation of a variety of mutagenic compounds by the reconstituted system containing highly purified preparations of cytochrome P-450 from rat liver.
Topics: Aflatoxin B1; Aflatoxins; Amino Acids; Animals; Azo Compounds; Benzoflavones; beta-Naphthoflavone; Biotransformation; Carcinogens; Cytochrome P-450 Enzyme System; In Vitro Techniques; Inactivation, Metabolic; Liver; Male; Mutagens; NADPH-Ferrihemoprotein Reductase; Nitro Compounds; Phenobarbital; Polycyclic Compounds; Rats; Rats, Inbred Strains | 1985 |
Effects of phenobarbitone and beta-naphthoflavone on hepatic microsomal drug metabolising enzymes of the male beagle dog.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Dogs; Enzyme Induction; Flavonoids; Male; Microsomes, Liver; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Organ Size; Oxidoreductases; Oxygenases; Phenobarbital; Rats | 1985 |
Complete amino acid sequence of a cytochrome P-450 isolated from beta-naphthoflavone-induced rabbit liver microsomes. Comparison with phenobarbital-induced and constitutive isozymes and identification of invariant residues.
Topics: Amino Acid Sequence; Animals; Benzoflavones; beta-Naphthoflavone; Chromatography, Gel; Chromatography, High Pressure Liquid; Cyanogen Bromide; Cytochrome P-450 Enzyme System; Enzyme Induction; Flavonoids; Isoenzymes; Microsomes, Liver; Phenobarbital; Rabbits; Rats | 1986 |
Microsomal metabolism of the carcinogen, N-2-fluorenylacetamide, by the mammary gland and liver of female rats. I. Ring- and N-hydroxylations of N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome b Group; Cytochrome P-450 Enzyme System; Cytochromes b5; Enzyme Induction; Female; Hydroxylation; In Vitro Techniques; Lactation; Mammary Glands, Animal; Methylcholanthrene; Microsomes; Microsomes, Liver; Phenobarbital; Pregnancy; Rats; Rats, Inbred Strains | 1985 |
Bromobenzene metabolism in isolated rat hepatocytes. 18O2 incorporation studies.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Bromobenzenes; Catechols; In Vitro Techniques; Liver; Male; Oxygen Isotopes; Phenobarbital; Rats; Rats, Inbred Strains | 1985 |
A comparison of the effects of hexachlorobenzene, beta-naphthoflavone, and phenobarbital on cytochrome P-450 and mixed-function oxidases in Japanese quail.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Body Weight; Chemical and Drug Induced Liver Injury; Chlorobenzenes; Coturnix; Electrophoresis, Polyacrylamide Gel; Female; Flavonoids; Hexachlorobenzene; Injections, Intraperitoneal; Liver Diseases; Microsomes, Liver; Mixed Function Oxygenases; Organ Size; Oxygenases; Phenobarbital; Porphyrias | 1985 |
Altered induction response of hepatic cytochrome P-450 to phenobarbital, 3-methylcholanthrene, and beta-naphthoflavone in organotin-treated animals.
Topics: 5-Aminolevulinate Synthetase; Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Environmental Exposure; Enzyme Induction; Flavonoids; Liver; Male; Methylcholanthrene; Organotin Compounds; Phenobarbital; Proteins; Rats; Rats, Inbred Strains | 1985 |
Regulation of aromatic oxidation of estradiol-17 beta in maternal hepatic, fetal hepatic and placental tissues: comparative effects of a series of inducing agents.
Topics: Animals; Aroclors; Benzoflavones; beta-Naphthoflavone; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 CYP1A1; Estradiol; Ethanol; Female; Liver; Male; Methylcholanthrene; Phenobarbital; Placenta; Polychlorinated Dibenzodioxins; Pregnancy; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Safrole; Steroid Hydroxylases | 1985 |
Additional routes in the metabolism of phenacetin.
Topics: Acetylation; Animals; Benzoflavones; beta-Naphthoflavone; Biotransformation; Chromatography, Thin Layer; Cytochrome P-450 Enzyme System; Cytosol; Enzyme Induction; Female; Hydroxylation; In Vitro Techniques; Liver; Magnetic Resonance Spectroscopy; Male; Methylcholanthrene; Microsomes, Liver; Oxidation-Reduction; Phenacetin; Phenobarbital; Rabbits; Rats; Rats, Inbred Strains | 1985 |
Benzene myeloclastogenicity: a function of its metabolism.
Topics: Animals; Benzene; Benzoflavones; beta-Naphthoflavone; Bone Marrow; Catechols; Chromosome Aberrations; Enzyme Induction; Female; Germ-Free Life; Hydroquinones; Male; Methylcholanthrene; Mice; Mixed Function Oxygenases; Phenobarbital; Phenol; Phenols; Sex Factors | 1985 |
Effects of acetylenic and olefinic pyrenes upon cytochrome P-450 dependent benzo[a]pyrene hydroxylase activity in liver microsomes.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; Benzopyrene Hydroxylase; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; In Vitro Techniques; Microsomes, Liver; Phenobarbital; Pyrenes; Rats; Structure-Activity Relationship | 1985 |
Effect of promethazine and isosafrole on rat-hepatic microsomal mono-oxygenase activity: comparison with classic inducers phenobarbitone and beta-naphthoflavone.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Body Weight; Dioxoles; Enzyme Induction; Flavonoids; Male; Microsomes, Liver; Organ Size; Oxygenases; Phenobarbital; Promethazine; Rats; Rats, Inbred Strains; Safrole | 1985 |
Isozyme selectivity of the inhibition of rat liver cytochromes P-450 by chloramphenicol in vivo.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Chloramphenicol; Clofibrate; Cytochrome P-450 Enzyme Inhibitors; Isoenzymes; Lauric Acids; Liver; Male; Mixed Function Oxygenases; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Safrole; Steroid 16-alpha-Hydroxylase; Substrate Specificity; Testosterone; Warfarin | 1985 |
Selective inhibitory interactions of alkoxymethylenedioxybenzenes towards mono-oxygenase activity in rat-hepatic microsomes.
Topics: Aminopyrine N-Demethylase; Animals; Benzoflavones; Benzopyrene Hydroxylase; beta-Naphthoflavone; Carbon Monoxide; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Dioxoles; Enzyme Induction; Isoenzymes; Male; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1985 |
[Effect of a new sleep inducer, 1H-1,2,4-triazolyl benzophenone derivative 450191-S on rat liver drug-metabolizing enzyme system].
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Drug Interactions; Hypnotics and Sedatives; Liver; Male; Microsomes, Liver; Nitrazepam; Pentobarbital; Phenobarbital; Rats; Rats, Inbred Strains; Triazoles | 1985 |
Effects of pretreatment with pyrazole and inducers of mixed function oxidases on DNA repair elicited by dimethylnitrosamine in rat hepatocytes in vivo and in vitro.
Topics: Animals; Aroclors; Benzoflavones; beta-Naphthoflavone; Cells, Cultured; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 CYP2E1; DDT; Diethylnitrosamine; Dimethylnitrosamine; DNA Repair; Enzyme Induction; Liver; Male; Methyl Methanesulfonate; Methylcholanthrene; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Phenobarbital; Pyrazoles; Rats; Rats, Inbred Strains | 1985 |
The influence of triiodothyronine (T3) and inducers on hepatic drug metabolism in rats of different ages.
Topics: Age Factors; Animals; Benzoflavones; beta-Naphthoflavone; Biotransformation; Coumarins; Cytochrome P-450 Enzyme System; Ethylmorphine; Liver; Male; Phenobarbital; Rats; Rats, Inbred Strains; Triiodothyronine | 1985 |
Effects of drug-metabolizing enzyme inducers on cephaloridine toxicity in Fischer 344 rats.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cephaloridine; Drug Interactions; Enzyme Induction; Kidney; Phenobarbital; Piperonyl Butoxide; Polybrominated Biphenyls; Rabbits; Rats; Rats, Inbred F344; Rats, Inbred Strains; Stilbenes | 1982 |
1,1,1-Trichloropropene-2,3-oxide: an alternate mechanism for its inhibition of cytochrome P-450.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme Inhibitors; Ethers; Heme; Hydrocarbons, Chlorinated; In Vitro Techniques; Male; Microsomes, Liver; Mixed Function Oxygenases; NADP; Phenobarbital; Rats; Trichloroepoxypropane | 1982 |
The effect of monooxygenase inducing agents on the incorporation of [35S]methionine into hepatic microsomal protein of rainbow trout (Salmo gairdneri).
Topics: Animals; Autoradiography; Benzoflavones; beta-Naphthoflavone; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Methionine; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Polychlorinated Biphenyls; Rosaniline Dyes; Salmonidae; Time Factors; Trout | 1984 |
Monoclonal antibodies that inhibit enzyme activity of 3-methylcholanthrene-induced cytochrome P-450.
Topics: Animals; Antibodies, Monoclonal; Antibody Specificity; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzoflavones; Benzopyrenes; beta-Naphthoflavone; Binding Sites; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Epitopes; Humans; Hybridomas; Immunization; Methylcholanthrene; Mice; Microsomes, Liver; Phenobarbital; Protein Binding; Rabbits; Rats | 1982 |
Differential effect of phenobarbital and beta-naphthoflavone on the mRNAs coding for cytochrome P450 and NADPH cytochrome P450 reductase.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Flavonoids; Genetic Variation; Liver; Male; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Poly A; Polyribosomes; Protein Biosynthesis; Rats; Rats, Inbred Strains; RNA; RNA, Messenger | 1982 |
Comparative properties of purified cytochrome P-448 from beta-naphthoflavone treated rats and rainbow trout.
Topics: Animals; Benzo(a)pyrene; Benzoflavones; Benzopyrene Hydroxylase; Benzopyrenes; beta-Naphthoflavone; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; Epitopes; Flavonoids; Microsomes, Liver; Phenobarbital; Rats; Salmonidae; Species Specificity; Spectrophotometry; Substrate Specificity; Testosterone; Trout | 1983 |
The role of hepatic biotransformation in mediating the acute toxicity of the phosphorothionate insecticide chlorpyrifos.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Biotransformation; Chlorpyrifos; Hydrolysis; In Vitro Techniques; Inactivation, Metabolic; Kinetics; Male; Metabolic Clearance Rate; Mice; Microsomes, Liver; Oxidation-Reduction; Phenobarbital | 1984 |
Effects of phenobarbital, 3-methylcholanthrene and beta-naphthoflavone pretreatment on mouse liver microsomal enzymes and on metabolite patterns of benzo[a]pyrene.
Topics: Animals; Benzo(a)pyrene; Benzoflavones; Benzopyrenes; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Dihydroxydihydrobenzopyrenes; Flavonoids; In Vitro Techniques; Male; Methylcholanthrene; Mice; Mice, Inbred Strains; Microsomes, Liver; Phenobarbital; Proteins | 1981 |
Different patterns of benzo[a]pyrene metabolism of purified cytochromes P-450 from methylcholanthrene, beta-naphthoflavone and phenobarbital treated rats.
Topics: Animals; Benzo(a)pyrene; Benzoflavones; Benzopyrenes; beta-Naphthoflavone; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Enzyme Induction; Flavonoids; Inactivation, Metabolic; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains | 1982 |
Specificity in the interaction of phospholipids and fatty acids with vesicle reconstituted cytochrome P-450. A spin label study.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Electron Spin Resonance Spectroscopy; Fatty Acids; Kinetics; Microsomes, Liver; Phenobarbital; Phospholipids; Rabbits; Spin Labels | 1983 |
Effect of some xenobiotics on kynurenine hydrolase and kynurenine aminotransferase of mouse liver.
Topics: Animals; Aroclors; Benzo(a)pyrene; Benzoflavones; Benzopyrenes; beta-Naphthoflavone; Carcinogens; Chlorodiphenyl (54% Chlorine); Chlorpromazine; Female; Hydrolases; Liver; Lyases; Methylcholanthrene; Mice; Phenobarbital; Pyrazoles; Transaminases | 1983 |
Comparison of cytochrome P-450-dependent metabolism in different developmental stages of Drosophila melanogaster.
Topics: Animals; Benzo(a)pyrene; Benzoflavones; Benzopyrenes; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Drosophila melanogaster; Kinetics; Larva; Microsomes; Mutagens; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Spectrophotometry | 1983 |
Indole-3-carbinol protects against covalent binding of benzo[a]pyrene and N-nitrosodimethylamine metabolites to mouse liver macromolecules.
Topics: Animals; Aroclors; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzoflavones; Benzopyrenes; beta-Naphthoflavone; Chlorodiphenyl (54% Chlorine); Dimethylnitrosamine; DNA; Indoles; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred ICR; Phenobarbital; Rats | 1984 |
Use of a direct high performance liquid chromatography method for multiple testosterone hydroxylations in studies of microsomal monooxygenase activities.
Topics: Acetanilides; Aldrin; Animals; Benzo(a)pyrene; Benzoflavones; Benzopyrenes; beta-Naphthoflavone; Chromatography, High Pressure Liquid; Cricetinae; Cytochrome P-450 Enzyme System; Ethylmorphine; Male; Mesocricetus; Microsomes, Liver; Oxygenases; Phenobarbital; Pregnenolone Carbonitrile; Rifampin; Testosterone | 1984 |
Effect of polybrominated biphenyls, beta-naphthoflavone and phenobarbital on arylhydrocarbon hydroxylase activities and chloroform-induced nephrotoxicity and hepatotoxicity in male C57BL/6J and DBA/2J mice.
Topics: Alanine Transaminase; Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; beta-Naphthoflavone; Blood Urea Nitrogen; Chloroform; Dose-Response Relationship, Drug; Enzyme Induction; Flavonoids; Kidney; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Phenobarbital; Polybrominated Biphenyls; Species Specificity | 1984 |
Ethanol-inducible cytochrome P-450 is more susceptible to in vitro carbon tetrachloride-mediated destruction than phenobarbital-inducible and beta-naphthoflavone-inducible cytochromes P-450.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Benzoflavones; beta-Naphthoflavone; Biotransformation; Carbon Tetrachloride; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Ethanol; Free Radicals; Male; Microsomes, Liver; NADP; Nitroanisole O-Demethylase; Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains | 1984 |
Metabolic activation of promutagens, detectable in Ames' Salmonella assay, by 5000 X g supernatant of rat ventral prostate.
Topics: Animals; Aroclors; Aryl Hydrocarbon Hydroxylases; Benzoflavones; beta-Naphthoflavone; Biotransformation; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 CYP1A1; Enzyme Induction; Kinetics; Male; Microsomes; Mutagenicity Tests; Mutagens; Mutation; Oxidoreductases; Phenobarbital; Prostate; Rats; Rats, Inbred Strains; Salmonella typhimurium | 1983 |
Mutagenicity of structurally related aromatic amines in the Salmonella/mammalian microsome test with various S-9 fractions.
Topics: Amines; Animals; Aroclors; Benzoflavones; beta-Naphthoflavone; Biotransformation; Chlorodiphenyl (54% Chlorine); Enzyme Induction; In Vitro Techniques; Male; Microsomes; Mutagens; Phenobarbital; Rats; Rats, Inbred Strains; Salmonella typhimurium; Structure-Activity Relationship; Subcellular Fractions | 1983 |
A biochemical and electron microscopic study of changes in the content of cytochrome P-450 in rat livers after cessation of treatment with phenobarbital, beta-naphtoflavone or 3-methylcholanthrene.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Endoplasmic Reticulum; Flavonoids; Immunosorbent Techniques; Kinetics; Liver; Male; Methylcholanthrene; Microscopy, Electron; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains | 1984 |
Effect of aging on response to induction and metabolizing activity of the hepatic mixed-function oxidase system of male Sprague-Dawley rats.
Topics: Aging; Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome b Group; Cytochrome P-450 Enzyme System; Cytochromes b5; Enzyme Induction; Kinetics; Liver; Male; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred Strains | 1983 |
Development of basal and induced aryl hydrocarbon (benzo[a]pyrene) hydroxylase activity in the chicken embryo in ovo.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; Benzopyrene Hydroxylase; beta-Naphthoflavone; Cell Differentiation; Chick Embryo; Chickens; Enzyme Induction; Kinetics; Liver; Methylcholanthrene; Microsomes; Microsomes, Liver; Phenobarbital; Polychlorinated Biphenyls; Polychlorinated Dibenzodioxins | 1983 |
Effect of inducers and aging on rabbit liver microsomal drug-metabolizing enzymes.
Topics: Aging; Animals; Benzoflavones; beta-Naphthoflavone; Cholesterol; Cholestyramine Resin; Cytochrome b Group; Cytochrome P-450 Enzyme System; Cytochromes b5; Enzyme Induction; Female; Inactivation, Metabolic; Isoenzymes; Male; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Pregnancy; Rabbits | 1983 |
Quantification of NADPH: cytochrome P-450 reductase in liver microsomes by a specific radioimmunoassay technique.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Immune Sera; Immunodiffusion; In Vitro Techniques; Intracellular Membranes; Male; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Radioimmunoassay; Rats; Rats, Inbred Strains | 1983 |
Effects of polychlorinated biphenyl compounds, 2,3,7,8-tetrachlorodibenzo-p-dioxin, phenobarbital and iron on hepatic uroporphyrinogen decarboxylase. Implications for the pathogenesis of porphyria.
Topics: 5-Aminolevulinate Synthetase; Animals; Benzoflavones; beta-Naphthoflavone; Carboxy-Lyases; Cells, Cultured; Chick Embryo; Chromatography, High Pressure Liquid; Dioxins; Iron; Liver; Phenobarbital; Polychlorinated Biphenyls; Polychlorinated Dibenzodioxins; Porphyrias; Porphyrins; Uroporphyrinogen Decarboxylase | 1983 |
Immunochemical detection and quantitation of microsomal cytochrome P-450 and reduced nicotinamide adenine dinucleotide phosphate:cytochrome P-450 reductase in the rat ventral prostate.
Topics: Animals; Antigen-Antibody Complex; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Histocytochemistry; Immune Sera; Kinetics; Male; Microsomes; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Organ Specificity; Oxidation-Reduction; Phenobarbital; Prostate; Rats; Rats, Inbred Strains | 1983 |
Turnover of membrane proteins: kinetics of induction and degradation of seven forms of rat liver microsomal cytochrome P-450, NADPH-cytochrome P-450 reductase, and epoxide hydrolase.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Epoxide Hydrolases; Kinetics; Male; Membrane Proteins; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Rats; Rats, Inbred Strains | 1984 |
Hexachlorobenzene-induced porphyria in Japanese quail. Effect of pretreatment with phenobarbital or beta-naphthoflavone.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Benzoflavones; beta-Naphthoflavone; Chlorobenzenes; Coturnix; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Flavonoids; Glutathione Transferase; Hexachlorobenzene; Liver; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Oxidoreductases; Oxygenases; Phenobarbital; Porphyrias | 1984 |
Isoflurane: a comparison of its metabolism by human and rat hepatic cytochrome P-450.
Topics: Adult; Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Female; Fluorine; Humans; In Vitro Techniques; Isoflurane; Male; Microsomes, Liver; Middle Aged; Phenobarbital; Pregnenolone Carbonitrile; Rats; Species Specificity | 1984 |
Induction of cytochrome P-450 mRNAs quantitated by in vitro translation and immunoprecipitation.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Autoradiography; Benzoflavones; beta-Naphthoflavone; Chemical Precipitation; Cytochrome P-450 Enzyme System; Densitometry; Electrophoresis, Polyacrylamide Gel; Female; Immunochemistry; Kinetics; Male; Methylcholanthrene; Phenobarbital; Photofluorography; Protein Biosynthesis; Rats; Rats, Inbred Strains; RNA, Messenger; Sex Characteristics | 1984 |
1-Ethynylpyrene, a suicide inhibitor of cytochrome P-450 dependent benzo[a]pyrene hydroxylase activity in liver microsomes.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzoflavones; Benzopyrene Hydroxylase; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Kinetics; Male; Microsomes, Liver; NADP; Phenobarbital; Pyrenes; Rats; Rats, Inbred Strains; Spectrometry, Fluorescence | 1984 |
In vitro metabolism of 8-methoxypsoralen.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; In Vitro Techniques; Kinetics; Male; Methoxsalen; Mice; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains | 1984 |
The effect of hepatic mixed-function oxidase enzyme inducers on the development of tri-o-tolyl phosphate-induced delayed neurotoxicity.
Topics: Animals; Ataxia; Benzoflavones; beta-Naphthoflavone; Biotransformation; Carboxylic Ester Hydrolases; Chickens; Cresols; Enzyme Induction; Female; Liver; Mixed Function Oxygenases; Nervous System; Phenobarbital; Tritolyl Phosphates | 1984 |
Influence of cytochrome P-450 type on the pattern of conjugation of 7-hydroxycoumarin generated from 7-alkoxycoumarins.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Coumarins; Cytochrome P-450 Enzyme System; Dealkylation; Enzyme Induction; Ethanol; In Vitro Techniques; Kinetics; Male; Metyrapone; Microsomes, Liver; Oxazoles; Phenobarbital; Rats; Rats, Inbred Strains; Substrate Specificity; Umbelliferones | 1984 |
Cytochrome P-450-dependent oxidation of felodipine--a 1,4-dihydropyridine--to the corresponding pyridine.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Biotransformation; Cytochrome P-450 Enzyme System; Felodipine; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Nifedipine; Oxidation-Reduction; Phenobarbital; Rats; Rats, Inbred Strains | 1984 |
Cloning of cDNA coding for a rat liver protein whose expression is subject to gender-specific regulation by xenobiotics.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cloning, Molecular; Cytochrome P-450 Enzyme System; DNA; Flavonoids; Liver; Phenobarbital; Protein Biosynthesis; Proteins; Rats; RNA, Messenger; Sex Factors | 1984 |
Differences between small and large intestine and liver in the inducibility of microsomal enzymes in response to stimulation by phenobarbitone and betanaphthoflavone in the diet.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Enzyme Induction; Flavonoids; Intestine, Large; Intestine, Small; Liver; Male; Microsomes; Mixed Function Oxygenases; Oxidoreductases; Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains | 1984 |
Comparison of urethane-induced sister-chromatid exchanges in various murine strains, and the effect of enzyme inducers.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Crossing Over, Genetic; Drug Interactions; Male; Mice; Mice, Inbred Strains; Phenobarbital; Sister Chromatid Exchange; Species Specificity; Urethane | 1983 |
Metabolism of estradiol in liver cell culture. Differential responses of C-2 and C-16 oxidations to drugs and other chemicals that induce selective species of cytochrome P-450.
Topics: Allylisopropylacetamide; Animals; Aroclors; Benzoflavones; beta-Naphthoflavone; Cell Count; Cells, Cultured; Chick Embryo; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Estradiol; Liver; Methylcholanthrene; Phenobarbital | 1983 |
Liver microsomal cytochrome P-450-dependent O-dealkylation reaction in various animals.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Dealkylation; Guinea Pigs; Hexobarbital; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Microsomes, Liver; Phenobarbital; Rabbits; Rats; Rats, Inbred Strains; Species Specificity | 1983 |
Effects of various microsomal enzyme inducers on M-demethylation of chlorpromazine.
Topics: Animals; Aroclors; Benzoflavones; beta-Naphthoflavone; Biotransformation; Chlorodiphenyl (54% Chlorine); Chlorpromazine; Male; Methylation; Microsomes, Liver; Oxidoreductases, N-Demethylating; Pharmacology; Phenobarbital; Rats | 1983 |
The interaction of arylalkybenzimidazoles and related compounds with microsomal oxidation.
Topics: Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Aryl Hydrocarbon Hydroxylases; Benzimidazoles; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme Inhibitors; Male; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1983 |
Induction of hepatic cytochrome P-450 and drug metabolism by metyrapone in the rat: relevance to its effects in rat-liver cell culture.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cells, Cultured; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Enzyme Induction; Ethylmorphine-N-Demethylase; Inactivation, Metabolic; Male; Metyrapone; Microsomes, Liver; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred Strains | 1983 |
Effect of cadmium in vitro on benzphetamine-N-demethylation and ethoxyresorufin-O-deethylation in rats of different age.
Topics: Aging; Animals; Benzoflavones; beta-Naphthoflavone; Cadmium; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Enzyme Induction; In Vitro Techniques; Kinetics; Male; Oxidoreductases; Oxidoreductases, N-Demethylating; Phenobarbital; Rats; Rats, Inbred Strains | 1983 |
Cloning and sequence analysis of a rat liver cDNA coding for a phenobarbital-inducible microheterogenous cytochrome P-450 variant: regulation of its messenger level by xenobiotics.
Topics: Animals; Base Sequence; Benzoflavones; beta-Naphthoflavone; Chromosome Mapping; Cloning, Molecular; Cytochrome P-450 Enzyme System; DNA; Male; Phenobarbital; Rats; Rats, Inbred Strains; RNA, Messenger | 1983 |
Composition of cytochrome P-450 isozymes from hepatic microsomes of C57BL/6 and DBA/2 mice assessed by warfarin metabolism, immunoinhibition, and immunoelectrophoresis with anti-(rat cytochrome P-450).
Topics: Animals; Antibodies; Benzoflavones; beta-Naphthoflavone; Catalysis; Cytochrome P-450 Enzyme System; Enzyme Induction; Immunochemistry; Immunoelectrophoresis; Isoenzymes; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Microsomes, Liver; Phenobarbital; Pregnenolone Carbonitrile; Rats; Stereoisomerism; Warfarin | 1984 |
Interactions of nitrogen heterocycles with cytochrome P-450 and monooxygenase activity.
Topics: Animals; Benzoflavones; Benzopyrene Hydroxylase; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Enzyme Induction; Heterocyclic Compounds; Imidazoles; In Vitro Techniques; Male; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Protein Binding; Pyridines; Rats; Rats, Inbred Strains; Spectrophotometry; Structure-Activity Relationship | 1984 |
Purification and characterization of liver microsomal cytochromes p-450: electrophoretic, spectral, catalytic, and immunochemical properties and inducibility of eight isozymes isolated from rats treated with phenobarbital or beta-naphthoflavone.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Flavonoids; Immunologic Techniques; Isoenzymes; Male; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Spectrophotometry; Substrate Specificity | 1982 |
Biotransformation of 7, 12-dimethylbenz(a)anthracene(DMBA): on the genesis of DMBA-trans-dihydrodiols and DMBA-7- and 12-methylhydroxylated metabolites.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Benzoflavones; beta-Naphthoflavone; Carbon Disulfide; Flavonoids; Liver; Male; Mass Spectrometry; Methylcholanthrene; Metyrapone; Phenobarbital; Proadifen; Rats; Structure-Activity Relationship | 1980 |
Separation and purification of liver microsomal monooxygenases from induced and untreated pigs.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Ethanol; Immunodiffusion; Male; Metyrapone; Microsomes, Liver; Phenobarbital; Spectrum Analysis; Swine | 1980 |
Purification of cytochrome P-450, NADPH-cytochrome P-450 reductase, and epoxide hydratase from a single preparation of rat liver microsomes.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Epoxide Hydrolases; Male; Methylcholanthrene; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Rats | 1980 |
Differences in the functional interaction of two purified cytochrome P-450 isozymes with epoxide hydrolase.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Epoxide Hydrolases; Isoenzymes; Liver; Naphthalenes; Phenobarbital; Polychlorinated Biphenyls; Rats | 1981 |
Effect of rifampicin on the mouse hepatic mixed-function oxidase system.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Male; Mice; Mice, Inbred C57BL; Microsomes, Liver; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Oxidoreductases; Phenobarbital; Pregnenolone Carbonitrile; Proadifen; Rifampin; Sodium Fluoride | 1981 |
Substrate specificity of age-related changes in the inducibility of hepatic microsomal monooxygenases in middle-aged rats.
Topics: Aging; Aniline Hydroxylase; Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Enzyme Induction; Male; Methyltestosterone; Microsomes, Liver; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Nitroanisole O-Demethylase; Oxidoreductases, N-Demethylating; Phenobarbital; Rats; Rats, Inbred F344 | 1981 |
Destruction of highly purified cytochromes P-450 associated with metabolism of fluorinated ether anesthetics.
Topics: Anesthetics; Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Ethers; Kinetics; Male; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1981 |
Induction of group-1 and group-2 UDP-glucuronosyltransferase in microsomes from the livers of C57 Bl/6 mice.
Topics: Animals; Aroclors; Benzoflavones; beta-Naphthoflavone; Chlorodiphenyl (54% Chlorine); Enzyme Induction; Glucuronosyltransferase; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Microsomes, Liver; Phenobarbital; Pregnenolone Carbonitrile; Safrole; Substrate Specificity | 1981 |
Differential induction of rat liver microsomal UDP-glucuronosyltransferase activites by various inducing agents.
Topics: Animals; Aroclors; Benzoflavones; Benzopyrene Hydroxylase; Benzopyrenes; beta-Naphthoflavone; Chlorodiphenyl (54% Chlorine); Clofibric Acid; DDT; Enzyme Induction; Glucuronosyltransferase; Male; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Stilbenes | 1982 |
Effect of some enzyme inducers, fluids, and methionine-thiosulfate on induced acute aflatoxicosis in goats.
Topics: Aflatoxin B1; Aflatoxins; Animals; Benzoflavones; beta-Naphthoflavone; Goats; Kidney; Liver; Male; Mortality; Phenobarbital; Phenylbutazone; Water | 1982 |
Hydroxylations in biosynthesis of bile acids. Cytochrome P-450 LM4 and 12alpha-hydroxylation of 5beta-cholestane-3alpha, 7alpha-diol.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Bile Acids and Salts; Catalysis; Cytochrome P-450 Enzyme System; Flavonoids; Hydroxylation; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Rabbits; Starvation | 1982 |
Differential effects of aging on hepatic microsomal monooxygenase induction by phenobarbital and beta-naphthoflavone.
Topics: Aging; Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Enzyme Induction; Flavonoids; Male; Microsomes, Liver; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Oxidoreductases; Phenobarbital; Proteins; Rats; Rats, Inbred F344 | 1982 |
Reanalysis and clarification of the structures of alpha-naphthoflavone dihydrodiols formed by uninduced and induced rat liver microsomes from Charles River CD and Sprague-Dawley rats.
Topics: Animals; Aroclors; Benzoflavones; beta-Naphthoflavone; Chlorodiphenyl (54% Chlorine); Flavonoids; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Species Specificity | 1983 |
Effects of dihydrosafrole on cytochromes P-450 and drug oxidation in hepatic microsomes from control and induced rats.
Topics: Aminopyrine N-Demethylase; Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Dioxoles; Enzyme Induction; In Vitro Techniques; Male; Microsomes, Liver; Oxidation-Reduction; Pharmaceutical Preparations; Phenobarbital; Rats; Rats, Inbred Strains; Safrole | 1983 |
Species differences in cytochromes P-450 and epoxide hydrolase: comparisons of xenobiotic-induced hepatic microsomal polypeptides in hamsters and rats.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cricetinae; Cytochrome P-450 Enzyme System; Enzyme Induction; Epoxide Hydrolases; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Pregnenolone Carbonitrile; Rats; Species Specificity; Stilbenes | 1983 |
Metabolism of alpha-naphthoflavone and beta-naphthoflavone by rat liver microsomes and highly purified reconstituted cytochrome P-450 systems.
Topics: Animals; Antibodies; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Flavonoids; Isoenzymes; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Spectrophotometry, Ultraviolet | 1983 |
Multiple effects and metabolism of alpha-naphthoflavone in induced and uninduced hepatic microsomes.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; Benzopyrene Hydroxylase; beta-Naphthoflavone; Cricetinae; Cytochrome P-450 Enzyme System; Flavonoids; Kinetics; Male; Mesocricetus; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rabbits; Rats; Species Specificity | 1983 |
Metabolic activation of paracetamol by highly purified forms of cytochrome P-450.
Topics: Acetaminophen; Animals; Benzoflavones; beta-Naphthoflavone; Biotransformation; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; Epoxide Hydrolases; Liver; Male; Phenobarbital; Rats; Rats, Inbred Strains | 1983 |
N-alkylation of the haem moiety of cytochrome P-450 caused by substituted dihydropyridines. Preferential attack of different pyrrole nitrogen atoms after induction of various cytochrome P-450 isoenzymes.
Topics: Alkylation; Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Dicarbethoxydihydrocollidine; Enzyme Induction; Heme; In Vitro Techniques; Isoenzymes; Liver; Male; Phenobarbital; Protoporphyrins; Pyridines; Rats; Rats, Inbred Strains | 1983 |
Induction and repression of the major phenobarbital-induced cytochrome P-450 measured by radioimmunoassay.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; In Vitro Techniques; Intracellular Membranes; Male; Microsomes, Liver; Phenobarbital; Radioimmunoassay; Rats; Rats, Inbred Strains | 1983 |
Immunological and enzymatic comparison of hepatic cytochrome P-450 fractions from phenobarbital-, 3-methylcholanthrene-, beta-naphthoflavone- and 2,3,7,8- tetrachlorodibenzo-p-dioxin-treated rats.
Topics: Animals; Antibodies; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dioxins; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Flavonoids; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Polychlorinated Dibenzodioxins; Rats; Rats, Inbred Strains | 1983 |
Stability of microsomal mono-oxygenase during incubations for the liver microsomal assay with S9 fractions of mouse liver under various inductions.
Topics: Aminopyrine N-Demethylase; Animals; Benzoflavones; beta-Naphthoflavone; Female; Lipid Peroxides; Male; Mice; Microsomes, Liver; Mutagenicity Tests; Nitroanisole O-Demethylase; Oxidoreductases; Phenobarbital; Styrene; Styrenes | 1983 |
Cytochrome P-450 metabolic-intermediate complex formation and induction by macrolide antibiotics; a new class of agents.
Topics: Animals; Anti-Bacterial Agents; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; In Vitro Techniques; Male; Microsomes, Liver; Phenobarbital; Proadifen; Rabbits; Rats; Rats, Inbred Strains; Species Specificity; Troleandomycin | 1982 |
Mutagenic activation of 2,4-diaminoanisole and 2-amino-fluorene by isolated rat liver nuclei and microsomes.
Topics: Animals; Anisoles; Benzoflavones; beta-Naphthoflavone; Cell Nucleus; Cobalt; Flavonoids; Fluorenes; In Vitro Techniques; Liver; Male; Microsomes, Liver; Mutagens; NADP; Phenobarbital; Phenylenediamines; Rats; Salmonella typhimurium | 1980 |
Effects of phenobarbital and beta-naphthoflavone on the activation of cyclophosphamide to mutagenic metabolites in vitro by liver and kidney from male and female rats.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Biotransformation; Cyclophosphamide; Cytochrome P-450 Enzyme System; Female; Flavonoids; In Vitro Techniques; Kidney; Liver; Male; Microsomes; Microsomes, Liver; Mutagens; Phenobarbital; Rats; Salmonella typhimurium; Sex Factors | 1980 |
Modification of the mutagenicity and teratogenicity of cyclophosphamide in rats with inducers of the cytochromes P-450.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Biotransformation; Cyclophosphamide; Cytochrome P-450 Enzyme System; Female; Flavonoids; Humans; Kidney; Liver; Mutagenicity Tests; Mutagens; Phenobarbital; Pregnancy; Rats; Salmonella typhimurium; Teratogens | 1981 |
Kinetics and mechanism of carbon monoxide binding to purified liver microsomal cytochrome P-450 isozymes.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Carbon Monoxide; Cytochrome P-450 Enzyme System; Isoenzymes; Kinetics; Male; Microsomes, Liver; Phenobarbital; Protein Binding; Rabbits; Rats; Rats, Inbred Strains; Spectrophotometry | 1982 |
Effects of 3-methylcholanthrene, beta-naphthoflavone, and phenobarbital on the 3-methylcholanthrene-inducible isozyme of cytochrome P-450 within centrilobular, midzonal, and periportal hepatocytes.
Topics: Animals; Antigen-Antibody Complex; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Enzyme Induction; Flavonoids; Immune Sera; Isoenzymes; Male; Methylcholanthrene; Microscopy, Fluorescence; Microsomes, Liver; Organ Specificity; Phenobarbital; Rats | 1982 |
Evidence against an abstraction or direct insertion mechanism for cytochrome P-450 catalysed meta hydroxylations.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Deuterium; Hydroxylation; Male; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Warfarin | 1982 |
Heterogeneity of hepatic nicotine oxidase.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; Isoenzymes; Liver; Male; Methylcholanthrene; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred Strains | 1982 |
Induction of cytochrome P-450 related metabolic activities in the rat ventral prostate.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; Benzopyrene Hydroxylase; beta-Naphthoflavone; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Enzyme Induction; Flavonoids; Male; Oxidoreductases; Phenobarbital; Prostate; Rats; Rats, Inbred Strains | 1982 |
Toxicologic study of carboxyatractyloside (active principle in cocklebur--Xanthium strumarium) in rats treated with enzyme inducers and inhibitors and glutathione precursor and depletor.
Topics: Animals; Atractyloside; Benzoflavones; beta-Naphthoflavone; Cobalt; Cysteine; Glycosides; Kidney Tubules; Lethal Dose 50; Liver; Male; Maleates; Phenobarbital; Phenylbutazone; Piperonyl Butoxide; Plants, Toxic; Rats; Rats, Inbred Strains; Stanozolol | 1982 |
Metabolic-intermediate complex formation reveals major changes in rat hepatic cytochrome P-450 subpopulations in addition to those forms previously purified after phenobarbital, beta-naphthoflavone, and isosafrole induction.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Dioxoles; Flavonoids; Male; Microsomes, Liver; Molecular Weight; Phenobarbital; Rats; Rats, Inbred Strains; Safrole | 1982 |
Indole-3-carbinol and indole-3-acetonitrile influence on hepatic microsomal metabolism.
Topics: Animals; Aroclors; Benzoflavones; beta-Naphthoflavone; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Enzyme Induction; Indoles; Male; Mice; Mice, Inbred Strains; Microsomes, Liver; Phenobarbital; Rabbits; Rats; Rats, Inbred Strains; Species Specificity | 1982 |
Characterization of glutathione S-transferase activity in Echinococcus granulosus.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Dinitrochlorobenzene; Echinococcus; Glutathione; Glutathione Transferase; Hydrogen-Ion Concentration; Phenobarbital; Spectrophotometry; Subcellular Fractions; Temperature | 1982 |
[Levels of xenobiotic metabolizing enzyme activities of xenobiotic tissue in different animal species].
Topics: Aminopyrine N-Demethylase; Animals; Benzoflavones; beta-Naphthoflavone; Female; Lipid Peroxides; Male; Mice; Microsomes, Liver; Nitroanisole O-Demethylase; Oxidoreductases; Phenobarbital; Species Specificity | 1982 |
Spectral and metabolic properties of liver microsomes from imidazole-pretreated rabbits.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Dimethylnitrosamine; Imidazoles; In Vitro Techniques; Male; Microsomes, Liver; Phenobarbital; Rabbits; Spectrophotometry | 1982 |
Heterogeneous distribution of the cytochrome P-450 monooxygenase system in rat liver lobes.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Fasting; Glucose; Liver; Male; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred Strains; Thyroxine | 1982 |
The influence of five monoxygenase inducers on liver cytosol estradiol receptor levels in the ovariectomized adult rat.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; Benzopyrenes; beta-Naphthoflavone; Castration; Cytosol; Enzyme Induction; Female; Liver; Methylcholanthrene; Oxygenases; Phenobarbital; Pregnenolone Carbonitrile; Rats; Receptors, Estradiol; Receptors, Estrogen | 1981 |
Induction of nuclear styrene monooxygenase and epoxide hydrolase in rat liver.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cell Nucleus; Enzyme Induction; Epoxide Hydrolases; Kinetics; Liver; Male; Oxygenases; Phenobarbital; Rats | 1981 |
Metabolism of alpha-naphthoflavone by rat liver microsomes.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Flavonoids; Male; Microsomes, Liver; NADP; Phenobarbital; Rats; Spectrum Analysis; Time Factors | 1981 |
Bromobenzene metabolism in the rabbit: specific forms of cytochrome P-450 involved in 2,3- and 3,4-epoxidation.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Bromobenzenes; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; In Vitro Techniques; Microsomes, Liver; Phenobarbital; Phenols; Rabbits | 1981 |
Effects of phenobarbital, beta-naphthoflavone, dexamethasone, and formamidoxime on the turnover of inducible microsomal proteins in cultured hepatocytes.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cells, Cultured; Chick Embryo; Dexamethasone; Flavonoids; Hydroxylamines; Kinetics; Microsomes, Liver; Molecular Weight; Oximes; Phenobarbital; Protein Biosynthesis | 1981 |
Changes in the metabolic profiles of R- and S-warfarin and R- and S-phenprocoumon as a probe to categorize the effect of inducing agents on microsomal hydroxylases.
Topics: 4-Hydroxycoumarins; Animals; Aroclors; Benzoflavones; beta-Naphthoflavone; Enzyme Induction; Male; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Phenprocoumon; Polychlorinated Dibenzodioxins; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Stereoisomerism; Warfarin | 1981 |
Enhanced biotransformation of nitrofurantoin in rats after induction with 3-methylcholanthrene or beta-naphthoflavone.
Topics: Aerobiosis; Animals; beta-Naphthoflavone; Biotransformation; Enzyme Induction; Flavonoids; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Nitrofurantoin; Phenobarbital; Rats | 1980 |
Induction of the hepatic cytochrome P-450-dependent mono-oxygenase system in young and geriatric rats.
Topics: Aging; Animals; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Enzyme Induction; Flavonoids; Male; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred F344 | 1980 |
Effect of diet and drugs on the qualitative and quantitative distribution of cytochromes P-450 in rat liver.
Topics: Animals; beta-Naphthoflavone; Body Weight; Cytochrome P-450 Enzyme System; Diet; Ethanol; Flavonoids; Male; Microsomes, Liver; Phenobarbital; Rats | 1980 |
Association between ornithine decarboxylase induction and the Ah locus in mice treated with polycyclic aromatic compounds.
Topics: Alleles; Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrenes; beta-Naphthoflavone; Carboxy-Lyases; Dioxins; Enzyme Induction; Flavonoids; Kidney; Liver; Methylcholanthrene; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Phenobarbital; Polychlorinated Dibenzodioxins; Protein Kinases; Species Specificity | 1980 |
Influence of aging and induction of rat liver and kidney microsomal mixed function oxidase systems.
Topics: Aging; Animals; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Enzyme Induction; Flavonoids; In Vitro Techniques; Kidney; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Rats; Warfarin | 1980 |
Role of detoxication pathways in acute toxicity levels of phosphorothionate insecticides in the rat.
Topics: Acetylcholinesterase; Animals; Benzoflavones; beta-Naphthoflavone; Calcium; Carboxylesterase; Carboxylic Ester Hydrolases; Cerebral Cortex; Chlorpyrifos; Cytochrome P-450 Enzyme System; Edetic Acid; Female; Glutathione; Inactivation, Metabolic; Male; Medulla Oblongata; Microsomes, Liver; Paraoxon; Parathion; Phenobarbital; Rats; Rats, Sprague-Dawley; Sex Factors | 1994 |
Induction of liver microsomal cytochrome P450 in cynomolgus monkeys.
Topics: Alkylation; Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzoflavones; beta-Naphthoflavone; Blotting, Western; Caffeine; Coumarins; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; Cytochromes b5; Dexamethasone; Enzyme Induction; Female; Hydroxylation; Isoenzymes; Macaca fascicularis; Male; Microsomes, Liver; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Oxazines; Oxidation-Reduction; Phenobarbital; Sex Factors; Species Specificity; Testosterone | 1995 |
Acitretin elimination in Sprague-Dawley rats pretreated with phenobarbital or beta-naphthoflavone.
Topics: Acitretin; Animals; Benzoflavones; beta-Naphthoflavone; Biotransformation; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Enzyme Induction; Liver; Male; Microsomes, Liver; Organ Size; Phenobarbital; Rats; Rats, Sprague-Dawley | 1995 |
The cytotoxicity of mitomycin C and adriamycin in genetically engineered V79 cell lines and freshly isolated rat hepatocytes.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cell Death; Cells, Cultured; Cricetinae; Cricetulus; Cyclophosphamide; Cytochrome P-450 Enzyme System; Dihydroxydihydrobenzopyrenes; Doxorubicin; Enzyme Induction; Enzyme Inhibitors; Fibroblasts; L-Lactate Dehydrogenase; Liver; Male; Maleates; Metyrapone; Mitomycin; Phenobarbital; Rats; Rats, Wistar; Transfection | 1995 |
beta-Naphthoflavone- and self-induced metabolism of 3,3',4,4'-tetrachlorobiphenyl in hepatic microsomes of the male, pregnant female and foetal rat.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Dexamethasone; Female; Gas Chromatography-Mass Spectrometry; Hydroxylation; Liver; Male; Microsomes, Liver; NADP; Oxidoreductases; Phenobarbital; Polychlorinated Biphenyls; Pregnancy; Rats; Rats, Wistar | 1995 |
3,5-Dichloroaniline toxicity in Fischer 344 rats pretreated with inhibitors and inducers of cytochrome P450.
Topics: Alanine Transaminase; Analysis of Variance; Aniline Compounds; Animals; Benzoflavones; beta-Naphthoflavone; Blood Urea Nitrogen; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Injections, Intraperitoneal; Kidney Cortex; Liver; Male; Organ Size; Oxazoles; p-Aminohippuric Acid; Phenobarbital; Piperonyl Butoxide; Pyridines; Rats; Rats, Inbred F344 | 1995 |
1H NMR T1 relaxation rate study on substrate orientation of fluoromethylanilines in the active sites of microsomal and purified cytochromes P450 1A1 and 2B1.
Topics: Aniline Compounds; Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; beta-Naphthoflavone; Binding Sites; Cytochrome P-450 Enzyme System; Enzyme Induction; Fluorine Compounds; Ligands; Magnetic Resonance Spectroscopy; Microsomes; Phenobarbital; Protons; Rats; Steroid Hydroxylases | 1995 |
Multiplicity of cytochrome P-450 species involved in theophylline metabolism in mouse hepatic microsomes.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Dealkylation; Hydroxylation; In Vitro Techniques; Isoenzymes; Male; Mice; Mice, Inbred Strains; Microsomes, Liver; Phenobarbital; Theophylline | 1995 |
Effect of nifedipine, verapamil and diltiazem on the enzyme-inducing activity of phenobarbital and beta-naphthoflavone.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Diltiazem; Enzyme Induction; Male; Nifedipine; Oxidoreductases; Phenobarbital; Rats; Rats, Wistar; Verapamil | 1995 |
Activation of alkylhydrazines to free radical intermediates by ethanol-inducible cytochrome P-4502E1 (CYP2E1).
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Electron Spin Resonance Spectroscopy; Enzyme Induction; Ethanol; Free Radicals; Humans; Hydrazines; Male; Microsomes, Liver; NADP; Nitrogen Oxides; Oxidoreductases, N-Demethylating; Phenobarbital; Pyridines; Rats; Rats, Sprague-Dawley; Spin Labels | 1995 |
cAMP-associated inhibition of phenobarbital-inducible cytochrome P450 gene expression in primary rat hepatocyte cultures.
Topics: Albumins; Animals; Aryl Hydrocarbon Hydroxylases; Base Sequence; Benzoflavones; beta-Naphthoflavone; Bucladesine; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; Dichlororibofuranosylbenzimidazole; Dose-Response Relationship, Drug; Enzyme Induction; Gene Expression Regulation, Enzymologic; Glucagon; Liver; Mixed Function Oxygenases; Molecular Sequence Data; Phenobarbital; Phosphodiesterase Inhibitors; Rats; Stereoisomerism; Steroid Hydroxylases; Thionucleotides; Transcriptional Activation | 1995 |
Induction of cytochrome P-450 isoenzymes in cultured monkey hepatocytes.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; beta-Naphthoflavone; Blotting, Western; Cells, Cultured; Coumarins; Cytochrome P-450 Enzyme System; Enzyme Induction; Isoenzymes; Liver; Male; Oxidoreductases, O-Demethylating; Phenobarbital; Rifampin; Saimiri; Steroid Hydroxylases | 1995 |
The effect of inducers and inhibitors of urethane metabolism on its in vitro and in vivo metabolism in rats.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Carbon Dioxide; Ditiocarb; Ethanol; In Vitro Techniques; Male; Phenobarbital; Pyridines; Rats; Rats, Sprague-Dawley; Urethane | 1994 |
Evaluation of the xenobiotic biotransformation capability of six rodent hepatoma cell lines in comparison with rat hepatocytes.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; beta-Naphthoflavone; Biotransformation; Cells, Cultured; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Liver; Liver Neoplasms, Experimental; Methylcholanthrene; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Rats; Testosterone; Tumor Cells, Cultured; Xenobiotics | 1994 |
2-Butanol metabolism by rat hepatic and pulmonary cytochromes P450.
Topics: Alcohol Oxidoreductases; Animals; Benzoflavones; beta-Naphthoflavone; Butanols; Cytochrome P-450 Enzyme System; Enzyme Induction; Ethanol; Isoenzymes; Lung; Male; Microsomes; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Rats; Rats, Sprague-Dawley | 1994 |
Interactions of peroxyquinols with cytochromes P450 2B1, 3A1, and 3A5: influence of the apoprotein on heterolytic versus homolytic O-O bond cleavage.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; Male; Microsomes, Liver; Mixed Function Oxygenases; Oxygen; Phenobarbital; Quinones; Rats; Rats, Sprague-Dawley; Steroid Hydroxylases | 1995 |
Stability of microsomal monooxygenases in murine liver S9 fractions derived from phenobarbital and beta-naphthoflavone induced animals under various long-term conditions of storage.
Topics: Aminopyrine N-Demethylase; Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Stability; Female; Male; Mice; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Sex Factors; Tissue Preservation | 1994 |
Bioactivation of arachidonic acid by the cytochrome P450 monooxygenases of guinea pig lung: the orthologue of cytochrome P450 2B4 is solely responsible for formation of epoxyeicosatrienoic acids.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Guinea Pigs; Lung; Male; Metyrapone; Microsomes; Microsomes, Liver; NADP; Phenobarbital; Proadifen; Triazoles | 1994 |
N-aralkylated derivatives of 1-aminobenzotriazole are potent isozyme- and lung-selective mechanism-based inhibitors of guinea pig cytochrome P-450 in vivo.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme Inhibitors; Enzyme Activation; Guinea Pigs; Isoenzymes; Liver; Lung; Male; Phenobarbital; Sensitivity and Specificity; Triazoles | 1994 |
Evidence for the transient expression of P-450 during the neonatal period in rat.
Topics: Amino Acid Sequence; Animals; Animals, Newborn; Benzoflavones; beta-Naphthoflavone; Blotting, Western; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Female; Kidney; Liver; Lung; Male; Microsomes, Liver; Molecular Sequence Data; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley | 1994 |
Influence of inducers and inhibitors of cytochrome P450 on the hepatotoxicity of hydrazine in vivo.
Topics: Acetone; Adenosine Triphosphate; Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Glutathione; Hydrazines; Isoniazid; Liver; Male; Phenobarbital; Piperonyl Butoxide; Rats; Rats, Sprague-Dawley; Triglycerides | 1994 |
The effects on rat thyroid function of an hepatic microsomal enzyme inducer.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Depression, Chemical; Enzyme Induction; Male; Microsomes, Liver; Mixed Function Oxygenases; Organ Size; Phenobarbital; Pituitary Gland; Rats; Rats, Inbred Strains; Thyroid Function Tests; Thyroid Gland; Thyroid Hormones; Thyrotropin; Thyroxine; Triiodothyronine | 1993 |
Retinal dehydrogenation and retinoic acid 4-hydroxylation in rat hepatic microsomes: developmental studies and effect of foreign compounds on the activities.
Topics: Aging; Aldehyde Oxidoreductases; Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Dexamethasone; Dimethyl Sulfoxide; Female; Hydrogenation; Hydroxylation; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Phenobarbital; Rats; Rats, Wistar; Retinal Dehydrogenase; Retinaldehyde; Tretinoin | 1994 |
Effects of age, phenobarbital, beta-naphthoflavone and dexamethasone on rat hepatic heme oxygenase.
Topics: Age Factors; Animals; Benzoflavones; beta-Naphthoflavone; Dexamethasone; Enzyme Induction; Heme Oxygenase (Decyclizing); Male; Microsomes, Liver; Phenobarbital; Rats; Rats, Wistar | 1994 |
Quantitative analyses of electrostatic interactions between NADPH-cytochrome P450 reductase and cytochrome P450 enzymes.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Electrochemistry; Enzyme Induction; Isoenzymes; Kinetics; Male; Mathematics; Microsomes, Liver; Models, Theoretical; NADPH-Ferrihemoprotein Reductase; Osmolar Concentration; Phenobarbital; Rabbits; Structure-Activity Relationship; Thermodynamics | 1994 |
Induction of tamoxifen-4-hydroxylation by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), beta-naphthoflavone (beta NF), and phenobarbital (PB) in avian liver: identification of P450 TCDDAA as catalyst of 4-hydroxylation induced by TCDD and beta NF.
Topics: Animals; Benzo(a)pyrene; Benzoflavones; beta-Naphthoflavone; Chick Embryo; Chickens; Cricetinae; Cytochrome P-450 Enzyme System; Enzyme Induction; Estrogen Antagonists; Female; Humans; Hydroxylation; Immunoglobulin G; Liver; Mesocricetus; Mice; Microsomes, Liver; Models, Biological; Phenobarbital; Polychlorinated Dibenzodioxins; Rats; Rats, Sprague-Dawley; Species Specificity; Tamoxifen | 1994 |
Effect of phenobarbital and other model inducers on cytochrome P450 isoenzymes in primary culture of dog hepatocytes.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Benzoflavones; beta-Naphthoflavone; Blotting, Western; Cells, Cultured; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Dogs; Enzyme Induction; Isoenzymes; Kinetics; Liver; Male; Microsomes, Liver; Omeprazole; Oxidoreductases; Phenobarbital; Rifampin; Steroid 16-alpha-Hydroxylase | 1993 |
Differences in induction by xenobiotics in murine tissues and the Hepa1c1c7 cell line of mRNAs encoding glutathione transferase, quinone reductase, and CYP1A P450s.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Butylated Hydroxyanisole; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Glutathione Transferase; Intestinal Mucosa; Liver; Mice; NAD(P)H Dehydrogenase (Quinone); Oxidoreductases; Phenobarbital; RNA, Messenger; Tumor Cells, Cultured; Xenobiotics | 1993 |
Effects of D-limonene on hepatic microsomal monooxygenase activity and paracetamol-induced glutathione depletion in mouse.
Topics: Acetaminophen; Acetone; Animals; Antineoplastic Agents; Benzoflavones; beta-Naphthoflavone; Cyclohexenes; Cytochrome P-450 Enzyme System; Glutathione; Limonene; Male; Mice; Microsomes, Liver; Oxygenases; Phenobarbital; Terpenes | 1993 |
Acetaminophen hepatotoxicity: influence of phenobarbital and beta-naphthoflavone treatment in obese and lean Zucker rats.
Topics: Acetaminophen; Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Enzyme Activation; Liver; Male; Mixed Function Oxygenases; Obesity; Phenobarbital; Rats; Rats, Zucker | 1993 |
Effects of capsaicin on liver microsomal metabolism of the tobacco-specific nitrosamine NNK.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Capsaicin; Carcinogens; Cricetinae; Enzyme Induction; Hydroxylation; In Vitro Techniques; Male; Mesocricetus; Microsomes, Liver; Nitrosamines; Oxidation-Reduction; Phenobarbital | 1993 |
Peripheral esterases in the rat: effects of classical inducers.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Clofibric Acid; Enzyme Induction; Esterases; Herbicides; Hydrolysis; Inactivation, Metabolic; Liver; Lung; Male; Paraoxon; Phenobarbital; Phenylacetates; Pyridines; Rats; Rats, Wistar; Skin | 1993 |
Interaction of caffeine with acetaminophen. 1. Correlation of the effect of caffeine on acetaminophen hepatotoxicity and acetaminophen bioactivation following treatment of mice with various cytochrome P450 inducing agents.
Topics: Acetaminophen; Acetone; Aminopyrine N-Demethylase; Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; Benzoquinones; beta-Naphthoflavone; Biotransformation; Caffeine; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; Drug Interactions; Enzyme Activation; Female; Imines; Isoenzymes; Kinetics; Liver Diseases; Mice; Microsomes, Liver; Oxidoreductases, N-Demethylating; Phenobarbital | 1993 |
Regulation of cytochrome P450 in cultured human colonic cells.
Topics: Adenocarcinoma; Animals; Benzo(a)pyrene; Benzoflavones; Benzopyrenes; beta-Naphthoflavone; Carcinoma, Hepatocellular; Colonic Neoplasms; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Enzyme Induction; Humans; Kinetics; Liver Neoplasms; Male; Methylcholanthrene; Microsomes; Microsomes, Liver; Oxidoreductases; Phenobarbital; Rats; Rats, Sprague-Dawley; Transcription, Genetic; Tumor Cells, Cultured | 1993 |
Hepatic cytochrome P450 induction in goats. Effects of model inducers on the metabolism of alkoxyresorufins, testosterone and ethylmorphine, and on apoprotein and mRNA levels.
Topics: Animals; Apolipoproteins; Aryl Hydrocarbon Hydroxylases; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Enzyme Induction; Ethylmorphine; Female; Goats; Isoenzymes; Liver; Male; Microsomes, Liver; Phenobarbital; Rats; RNA, Messenger; Steroid 16-alpha-Hydroxylase; Testosterone; Troleandomycin | 1993 |
Popliteal lymph node response to procainamide and isoniazid. Role of beta-naphthoflavone, phenobarbitone and S9-mix pretreatment.
Topics: Animals; Autoimmune Diseases; Benzoflavones; beta-Naphthoflavone; Biotransformation; Drug Evaluation, Preclinical; Enzyme Induction; Female; Isoniazid; Knee; Liver Extracts; Lymph Nodes; Male; Models, Biological; Phenobarbital; Procainamide; Rats; Rats, Inbred BN; Rats, Sprague-Dawley; Time Factors | 1993 |
Differences in the effects of model inducers of cytochrome P450 on the biotransformation of scoparone in rat and hamster liver.
Topics: Animals; Antihypertensive Agents; Benzoflavones; beta-Naphthoflavone; Biotransformation; Clofibrate; Coumarins; Cricetinae; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Guinea Pigs; Isoniazid; Liver; Male; Mesocricetus; Microsomes, Liver; Phenobarbital; Rats; Rats, Wistar; Species Specificity | 1993 |
Human alfentanil metabolism by cytochrome P450 3A3/4. An explanation for the interindividual variability in alfentanil clearance?
Topics: Alfentanil; Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Humans; In Vitro Techniques; Liver; Male; Microsomes, Liver; Phenobarbital; Pregnenolone Carbonitrile; Pyrazoles; Rats; Rats, Sprague-Dawley | 1993 |
Constitutive and inducible profile of glutathione S-transferase subunits in biliary epithelial cells and hepatocytes isolated from rat liver.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Bile; Cytosol; Enzyme Induction; Epithelium; Ethoxyquin; Glutathione Transferase; Liver; Male; Phenobarbital; Rats; Rats, Wistar | 1993 |
Expression analysis of the mixed function oxidase system in rat brain by the polymerase chain reaction.
Topics: Amitriptyline; Animals; Base Sequence; Benzoflavones; beta-Naphthoflavone; Brain; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Imipramine; Isoenzymes; Male; Mixed Function Oxygenases; Molecular Sequence Data; Nerve Tissue Proteins; Phenobarbital; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; RNA, Messenger; Safrole | 1993 |
Induction of cytochrome P-450-dependent enzyme activities in cultured rat liver slices.
Topics: Animals; Aroclors; Benzoflavones; beta-Naphthoflavone; Blotting, Western; Carcinogens; Cells, Cultured; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Enzyme Induction; Liver; Male; Mixed Function Oxygenases; Phenobarbital; Rats; Rats, Sprague-Dawley | 1993 |
Regulation of phenobarbital-inducible cytochrome P450 2B1/2 mRNA by lovastatin and oxysterols in primary cultures of adult rat hepatocytes.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cells, Cultured; Cholesterol; Clofibric Acid; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Fibric Acids; Hydroxycholesterols; Hypolipidemic Agents; L-Lactate Dehydrogenase; Liver; Lovastatin; Male; Mevalonic Acid; Phenobarbital; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1993 |
Effect of magnetic fields on rodent monooxygenase enzymes.
Topics: 7-Alkoxycoumarin O-Dealkylase; Aniline Hydroxylase; Animals; Benzoflavones; beta-Naphthoflavone; Blotting, Western; Cytochrome P-450 CYP2B1; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Electromagnetic Fields; Isoenzymes; Liver; Magnetics; Mice; Microsomes; Oxidoreductases; Oxidoreductases, N-Demethylating; Oxidoreductases, O-Demethylating; Phenobarbital; Rats; Rats, Wistar | 1995 |
Substrate influence on interaction between cytochrome P450 and cytochrome b5 in microsomes.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; beta-Naphthoflavone; Coumarins; Cross-Linking Reagents; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes b5; Ethyldimethylaminopropyl Carbodiimide; In Vitro Techniques; Microsomes, Liver; Oxidoreductases; Phenobarbital; Rabbits; Steroid Hydroxylases; Substrate Specificity | 1996 |
Metabolic interconversion of acid metabolites of cotinine in vitro.
Topics: Animals; Aroclors; Benzoflavones; beta-Naphthoflavone; Biotransformation; Chlorodiphenyl (54% Chlorine); Chromatography, High Pressure Liquid; Cotinine; Cricetinae; Guinea Pigs; In Vitro Techniques; Liver; Male; Mesocricetus; Oxidation-Reduction; Phenobarbital; Rabbits; Rats; Rats, Wistar; Spectrophotometry, Ultraviolet; Subcellular Fractions | 1995 |
Evaluation of phenobarbital/beta-naphthoflavone as an alternative S9-induction regime to Aroclor 1254 in the rat for use in in vitro genotoxicity assays.
Topics: Administration, Oral; Animals; Aroclors; Benzo(a)pyrene; Benzoflavones; beta-Naphthoflavone; Carcinogens; Chlorodiphenyl (54% Chlorine); Chromosome Aberrations; Cytochrome P-450 Enzyme System; Dimethylnitrosamine; Female; Humans; Liver Extracts; Lymphocytes; Male; Mutagenicity Tests; Phenobarbital; Rats; Salmonella typhimurium | 1995 |
Isolation of N-vinylprotoporphyrin IX after hepatic cytochrome P450 inactivation by 3-[(arylthio)ethyl]sydnone in chick embryos pretreated with phenobarbital, glutethimide, dexamethasone, and beta-naphthoflavone: differential inhibition of ferrochelatase
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Chick Embryo; Cytochrome P-450 Enzyme Inhibitors; Dexamethasone; Ferrochelatase; Glutethimide; Liver; Phenobarbital; Protoporphyrins; Stereoisomerism; Sydnones | 1996 |
Correlations of the induction of microsomal epoxide hydrolase activity with phase II drug conjugating enzyme activities in rat liver.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Clofibric Acid; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Epoxide Hydrolases; Ethanol; Glucuronosyltransferase; Glutathione Transferase; Male; Microsomes, Liver; Oxidoreductases; Phenobarbital; Rats; Rats, Sprague-Dawley; Safrole | 1996 |
Cytochrome P450 catalyzed metabolism of 1,2-dibromoethane in liver microsomes of differentially induced rats.
Topics: Acetaldehyde; Adenosine; Animals; Benzoflavones; beta-Naphthoflavone; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Ethylene Dibromide; Hydrogen-Ion Concentration; Hypnotics and Sedatives; Isoenzymes; Kinetics; Male; Microsomes, Liver; Molecular Structure; NADP; Phenobarbital; Pyrazoles; Rats; Rats, Wistar; Temperature | 1996 |
An ESR and spectrophotometric study of the denitration of nitroheterocyclic drugs by liver homogenates and their metabolic consumption by liver microsomes from cytochrome P-450-induced mice.
Topics: Aerobiosis; Anaerobiosis; Animals; Benzoflavones; beta-Naphthoflavone; Butylated Hydroxytoluene; Cytochrome P-450 Enzyme System; Electron Spin Resonance Spectroscopy; Enzyme Induction; Heterocyclic Compounds; Male; Mice; Microsomes, Liver; Nitracrine; Nitric Oxide; Phenobarbital; Polychlorinated Biphenyls; Quinolines | 1996 |
Identification and characterization of cytochrome P4501A1 amino acid residues interacting with a radiolabeled photoaffinity diazido-benzphetamine analogue.
Topics: 7-Alkoxycoumarin O-Dealkylase; Affinity Labels; Amino Acid Sequence; Animals; Azides; Benzoflavones; beta-Naphthoflavone; Binding Sites; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Heme; Microsomes, Liver; Molecular Sequence Data; NADPH-Ferrihemoprotein Reductase; Peptide Fragments; Phenobarbital; Photolysis; Rats; Tritium; Trypsin | 1996 |
Pneumotoxicity and hepatotoxicity of styrene and styrene oxide.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Bronchoalveolar Lavage Fluid; Buthionine Sulfoximine; Carcinogens; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Epoxy Compounds; gamma-Glutamyltransferase; Injections, Intraperitoneal; L-Iditol 2-Dehydrogenase; L-Lactate Dehydrogenase; Liver; Liver Diseases; Lung Diseases; Male; Methionine Sulfoximine; Mice; Phenobarbital; Pyridines; Styrene; Styrenes; Trichloroepoxypropane | 1996 |
Modulation of the mutagenicity and metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) by phenolic compounds.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Carcinogens, Environmental; Cricetinae; Cytochrome P-450 Enzyme System; Ellagic Acid; Male; Mesocricetus; Mutagens; Nitrosamines; Phenobarbital; Phenols | 1996 |
Human liver S-9 metabolic activation: proficiency in cytogenetic assays and comparison with phenobarbital/beta-naphthoflavone or aroclor 1254 induced rat S-9.
Topics: 2-Acetylaminofluorene; Aflatoxin B1; Animals; Aroclors; Benzo(a)pyrene; Benzoflavones; beta-Naphthoflavone; Biotransformation; Chlorodiphenyl (54% Chlorine); CHO Cells; Cricetinae; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Dimethylnitrosamine; Enzyme Induction; Humans; Liver; Mutagenicity Tests; Mutagens; Phenobarbital; Rats | 1996 |
Induction of cytochrome P450 isoenzymes in cultured precision-cut rat and human liver slices.
Topics: Animals; Aroclors; Benzoflavones; beta-Naphthoflavone; Chlorodiphenyl (54% Chlorine); Clofenapate; Clofibric Acid; Culture Techniques; Cytochrome P-450 Enzyme System; Enzyme Induction; Fibric Acids; Humans; Isoenzymes; Liver; Male; Microbodies; Phenobarbital; Pyrimidines; Rats; Rats, Sprague-Dawley | 1996 |
Influence of Aroclor 1254, phenobarbital, beta-naphthoflavone, and ethanol pretreatment on the biotransformation of cyclophosphamide in male and female rats.
Topics: Animals; Antineoplastic Agents, Alkylating; Aroclors; Benzoflavones; beta-Naphthoflavone; Biotransformation; Chlorodiphenyl (54% Chlorine); Chromatography, Gas; Cyclophosphamide; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Enzyme Induction; Ethanol; Female; Glutathione; Liver; Male; NAD; Oxidoreductases; Phenobarbital; Rats; Rats, Wistar | 1996 |
Quantitation of cytochrome P450 enzymes (CYP1A1/2, 2B11, 2C21 and 3A12) in dog liver microsomes by enzyme-linked immunosorbent assay.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; beta-Naphthoflavone; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Dogs; Enzyme-Linked Immunosorbent Assay; Female; Male; Microsomes, Liver; Phenobarbital; Rifampin; Steroid Hydroxylases | 1996 |
Microsomal cytochrome P450 peroxygenase metabolism of arachidonic acid in guinea pig liver.
Topics: Animals; Arachidonic Acid; Benzene Derivatives; beta-Naphthoflavone; Chromatography, High Pressure Liquid; Enzyme Induction; Ferric Compounds; Guinea Pigs; Hydroxyeicosatetraenoic Acids; Isoenzymes; Male; Microsomes, Liver; Mixed Function Oxygenases; NADP; Phenobarbital | 1996 |
7-Ethoxy-3,4-dimethylcoumarin: a substrate for a cytochrome P450-mediated mono-oxygenase activity that is highly induced by phenobarbitone and beta-naphthoflavone.
Topics: Animals; beta-Naphthoflavone; Coumarins; Cytochrome P-450 Enzyme System; Enzyme Induction; Male; Microsomes, Liver; Perfusion; Phenobarbital; Rats; Rats, Wistar | 1996 |
Anatomical distribution of NADPH-cytochrome P450 reductase and cytochrome P4502D forms in rat brain: effects of xenobiotics and sex steroids.
Topics: Animals; beta-Naphthoflavone; Brain; Cytochrome P-450 Enzyme System; DNA, Complementary; Estrogens; Female; Imipramine; NADH, NADPH Oxidoreductases; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; RNA, Messenger; Testosterone; Xenobiotics | 1996 |
Modulation of constitutive and inducible hepatic cytochrome(s) P-450 by interferon beta in mice.
Topics: Animals; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Enzyme Induction; Interferon-beta; Isoenzymes; Liver; Male; Mice; Phenobarbital | 1996 |
In vitro and in vivo oxidative biotransformation in the West-African dwarf goat (Caprus hircus aegagrus): substrate activities and effects of inducers.
Topics: Animals; Antipyrine; beta-Naphthoflavone; Biotransformation; Blotting, Western; Caffeine; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Goats; Isoniazid; Microsomes, Liver; Phenobarbital; Sulfamethazine; Troleandomycin | 1996 |
Metabolism of n-hexane by rat liver and extrahepatic tissues and the effect of cytochrome P-450 inducers.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; beta-Naphthoflavone; Brain; Cell Line; Corn Oil; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Ethanol; Hexanes; Hexanols; Humans; Liver; Lung; Male; Metyrapone; Microsomes; Microsomes, Liver; Muscle, Skeletal; Oxidoreductases, N-Demethylating; Phenobarbital; Random Allocation; Rats; Rats, Wistar | 1997 |
The role of different cytochrome P450 isoforms in in vitro chloroform metabolism.
Topics: Acetone; Animals; Aryl Hydrocarbon Hydroxylases; beta-Naphthoflavone; Biotransformation; Chloroform; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Dexamethasone; Drug Synergism; Enzyme Induction; Isoenzymes; Male; Microsomes, Liver; Phenobarbital; Pyrazoles; Rats; Rats, Sprague-Dawley; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases | 1996 |
Effects of inducers and inhibitors on the microsomal metabolism of styrene to styrene oxide in mice.
Topics: Animals; beta-Naphthoflavone; Carcinogens; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Ditiocarb; Enzyme Induction; Enzyme Inhibitors; Epoxy Compounds; Injections, Intraperitoneal; Lung; Male; Mice; Microsomes; Microsomes, Liver; Phenobarbital; Pyridines; Species Specificity; Styrene; Styrenes | 1997 |
Comutagenesis-III. In vitro metabolism of 2-amino-3-methylpyridine: the effect of various potential inhibitors, activators and inducers.
Topics: Amines; Aminopyridines; Animals; beta-Naphthoflavone; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Isoenzymes; Male; Microsomes, Liver; Mutagens; Oxidation-Reduction; Phenobarbital; Picolines; Polychlorinated Biphenyls; Proadifen; Rabbits | 1997 |
A specific hydroxysteroid UGT is responsible for the conjugation of aliphatic alcohols in rats: an estimation of the importance of glucuronidation versus oxidation.
Topics: Alcohols; Animals; beta-Naphthoflavone; Binding, Competitive; Enzyme Inhibitors; Ethanol; Glucuronates; Glucuronosyltransferase; Hydrogen-Ion Concentration; Hydroxysteroids; Male; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Rats; Rats, Wistar; Substrate Specificity | 1998 |
Ethylmorphine N-demethylase activity as a marker for cytochrome P450 CYP3A activity in rat hepatic microsomes.
Topics: Animals; Antibodies; Aryl Hydrocarbon Hydroxylases; beta-Naphthoflavone; Biomarkers; Clofibrate; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Enzyme Inhibitors; Ethylmorphine-N-Demethylase; Female; Isoniazid; Male; Microsomes, Liver; Oxidoreductases, N-Demethylating; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Sex Factors | 1998 |
Minimal effects of acrylonitrile on pulmonary and hepatic cell injury enzymes in rats with induced cytochrome P450.
Topics: Acetone; Acrylonitrile; Animals; beta-Naphthoflavone; Bronchoalveolar Lavage Fluid; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Ethanol; gamma-Glutamyltransferase; Isoenzymes; L-Iditol 2-Dehydrogenase; L-Lactate Dehydrogenase; Liver; Lung; Male; Phenobarbital; Pyridines; Rats; Rats, Sprague-Dawley | 1998 |
Differential response of cytosolic, microsomal, and mitochondrial glutathione S-transferases to xenobiotic inducers.
Topics: Animals; beta-Naphthoflavone; Blotting, Western; Brain; Cytosol; Dexamethasone; DNA Probes; Enzyme Induction; Glutathione Transferase; Isoenzymes; Liver; Lung; Male; Microsomes; Microsomes, Liver; Mitochondria; Mitochondria, Liver; Phenobarbital; Rats; Rats, Sprague-Dawley; RNA, Messenger; Subcellular Fractions | 1998 |
Transplantation of fetal liver tissue suspension into the spleens of adult syngenic rats: effects of beta-naphthoflavone, phenobarbital and dexamethasone on cytochrome P450 isoforms expression and on glycogen storage.
Topics: Animals; Anti-Inflammatory Agents; beta-Naphthoflavone; Cell Survival; Cell Transplantation; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Enzyme Inhibitors; Glycogen; Hypnotics and Sedatives; Isoenzymes; Liver; Male; Phenobarbital; Rats; Rats, Inbred F344; Spleen | 1998 |
Effect of phenobarbital and beta-naphthoflavone on activities of different rat esterases after paraoxon exposure.
Topics: Animals; beta-Naphthoflavone; Cholinesterase Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Esterases; Insecticides; Male; Paraoxon; Phenobarbital; Rats; Rats, Wistar | 1998 |
In vitro inhibition of thyroid hormone sulfation by hydroxylated metabolites of halogenated aromatic hydrocarbons.
Topics: Animals; Benzofurans; beta-Naphthoflavone; Biotransformation; Cytochrome P-450 Enzyme System; Diiodothyronines; Dioxins; Hydrocarbons, Halogenated; Hydroxylation; Isoenzymes; Male; Microsomes, Liver; Phenobarbital; Polychlorinated Biphenyls; Rats; Rats, Wistar; Structure-Activity Relationship; Sulfotransferases; Sulfur; Triiodothyronine | 1998 |
Biotransformation and elimination of 1-nitropyrene in the isolated perfused lung: effects of pretreating rats with phenobarbitone, beta-naphthoflavone, benz(A)anthracene or their mixtures.
Topics: Animals; Benz(a)Anthracenes; beta-Naphthoflavone; Biotransformation; Enzyme Inhibitors; In Vitro Techniques; Lung; Male; Mutagens; Perfusion; Phenobarbital; Pyrenes; Rats; Rats, Wistar | 1996 |
N-Dealkylation of chlorimipramine and chlorpromazine by rat liver microsomal cytochrome P450 isoenzymes.
Topics: Animals; Anticonvulsants; Antidepressive Agents, Tricyclic; Antipsychotic Agents; beta-Naphthoflavone; Chlorpromazine; Clomipramine; Cytochrome P-450 Enzyme System; Dealkylation; Drug Interactions; Enzyme Inhibitors; Isoenzymes; Male; Microsomes, Liver; Phenobarbital; Rats; Rats, Sprague-Dawley; Substrate Specificity | 1998 |
Phenobarbital, beta-naphthoflavone, clofibrate, and pregnenolone-16alpha-carbonitrile do not affect hepatic thyroid hormone UDP-glucuronosyl transferase activity, and thyroid gland function in mice.
Topics: Animals; beta-Naphthoflavone; Clofibrate; Cytochrome P-450 Enzyme System; Enzyme Induction; Glucuronosyltransferase; Liver; Male; Mice; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; Thyroid Gland; Thyroid Hormones | 1999 |
Transplantation of fetal liver tissue suspension into the spleens of adult syngenic rats: inducibility of cytochrome P450 dependent monooxygenase functions by beta-naphthoflavone, phenobarbital and dexamethasone.
Topics: Animals; beta-Naphthoflavone; Body Weight; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Female; Fetal Tissue Transplantation; Isoenzymes; Liver; Liver Transplantation; Male; Organ Size; Phenobarbital; Pregnancy; Rats; Rats, Inbred F344; Spleen; Time Factors | 1999 |
7-ethoxycoumarin deethylation activity in perfused isolated rat brain.
Topics: Animals; beta-Naphthoflavone; Brain; Coumarins; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Male; Perfusion; Phenobarbital; Rats; Rats, Wistar | 1999 |
Effect of cryopreservation on cytochrome P-450 enzyme induction in cultured rat hepatocytes.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; beta-Naphthoflavone; Cells, Cultured; Clofibric Acid; Cryopreservation; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Enzyme Inhibitors; Isoenzymes; Liver; Male; Phenobarbital; Rats; Rats, Sprague-Dawley | 1999 |
Triphenyltin acetate-mediated in vitro inactivation of rat liver cytochrome P-450.
Topics: Aminopyrine N-Demethylase; Animals; beta-Naphthoflavone; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytochromes; Dose-Response Relationship, Drug; Fungicides, Industrial; Male; Malondialdehyde; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Organotin Compounds; Phenobarbital; Rats; Rats, Wistar | 1999 |
Kinetics of drug metabolism in rat liver slices: IV. Comparison of ethoxycoumarin clearance by liver slices, isolated hepatocytes, and hepatic microsomes from rats pretreated with known modifiers of cytochrome P-450 activity.
Topics: Animals; beta-Naphthoflavone; Cell Separation; Coumarins; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Activation; Enzyme Inhibitors; In Vitro Techniques; Kinetics; Liver; Male; Microsomes, Liver; Phenobarbital; Rats; Rats, Sprague-Dawley; Triazoles | 1999 |
Identification of in vitro cytochrome P450 modulators to detect induction by prototype inducers in the mallard duckling (Anas platyrhynchos).
Topics: Animals; Benzimidazoles; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Ducks; Enzyme Induction; Microsomes, Liver; Oxazines; Oxidoreductases; Phenobarbital; Polychlorinated Biphenyls; Proadifen | 1999 |
A reporter gene assay to assess the molecular mechanisms of xenobiotic-dependent induction of the human CYP3A4 gene in vitro.
Topics: Alkaline Phosphatase; beta-Naphthoflavone; Caffeine; Carbamazepine; Carcinoma, Hepatocellular; Clofibrate; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Gene Expression Regulation; Genes, Reporter; Glucocorticoids; Hormone Antagonists; Humans; Isoniazid; Mifepristone; Mixed Function Oxygenases; Phenobarbital; Phenylbutazone; Phenytoin; Receptors, Glucocorticoid; Recombinant Proteins; Rifampin; Tumor Cells, Cultured; Xenobiotics | 1999 |
Alternatives in the induction and preparation of phenobarbital/naphthoflavone-induced S9 and their activation profiles.
Topics: Animals; beta-Naphthoflavone; Biotransformation; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Female; Liver; Mutagenicity Tests; Phenobarbital; Rats; Rats, Sprague-Dawley; Reproducibility of Results | 1999 |
A comparison of basal and induced hepatic microsomal cytochrome P450 monooxygenase activities in the cynomolgus monkey (Macaca fascicularis) and man.
Topics: Adult; Animals; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Female; Humans; Immunoblotting; Macaca fascicularis; Male; Microsomes, Liver; Middle Aged; Phenobarbital; Rifampin; Steroid Hydroxylases | 1999 |
Effects of pretreatment with cytochrome P-450 inducers, especially phenobarbital on triphenyltin metabolism and toxicity in hamsters.
Topics: Animals; Aspartate Aminotransferases; beta-Naphthoflavone; Blood Glucose; Carcinogens; Cricetinae; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Isoenzymes; Male; Mesocricetus; Methylcholanthrene; Microsomes, Liver; Organotin Compounds; Phenobarbital; Triglycerides | 1999 |
Association of cytochrome P450 induction with oxidative stress in vivo as evidenced by 3-hydroxylation of salicylate.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; beta-Naphthoflavone; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Enzyme Inhibitors; Gentisates; Hydroxybenzoates; Hydroxylation; Male; Oxidative Stress; Oxidoreductases, N-Demethylating; Phenobarbital; Proadifen; Rats; Rats, Sprague-Dawley; Salicylates | 1999 |
Glucose-6-phosphatase and age: biochemical and histochemical studies.
Topics: Aging; Animals; beta-Naphthoflavone; Dexamethasone; Enzyme Induction; Glucose-6-Phosphatase; Histocytochemistry; Liver; Male; Mixed Function Oxygenases; Phenobarbital; Rats; Rats, Wistar | 2000 |
Metabolite-intermediate complexation and inhibition of microsomal CYP3A in rat liver by diltiazem.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; beta-Naphthoflavone; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Desipramine; Dexamethasone; Diltiazem; Enzyme Inhibitors; Immunoblotting; Male; Microsomes, Liver; NADP; Oxidoreductases, N-Demethylating; Phenobarbital; Rats; Rats, Wistar; Spectrophotometry; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Testosterone | 2000 |
Cytochrome P450-dependent N-dealkylation of L-deprenyl in C57BL mouse liver microsomes: effects of in vivo pretreatment with ethanol, phenobarbital, beta-naphthoflavone and L-deprenyl.
Topics: Animals; beta-Naphthoflavone; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Disulfiram; Enzyme Induction; Enzyme Inhibitors; Ethanol; Fomepizole; In Vitro Techniques; Isoenzymes; Ketoconazole; Mice; Mice, Inbred C57BL; Microsomes, Liver; Monoamine Oxidase Inhibitors; NADH, NADPH Oxidoreductases; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Pyrazoles; Selegiline | 2000 |
Regulation of glutathione S-transferase enzymes in primary cultures of rat hepatocytes maintained under various matrix configurations.
Topics: Animals; beta-Naphthoflavone; Cells, Cultured; Chromatography, High Pressure Liquid; Cytosol; Dexamethasone; Enzyme Induction; Enzyme Inhibitors; Extracellular Space; Glutathione Transferase; Liver; Male; Phenobarbital; Rats; Rats, Sprague-Dawley | 2000 |
Induction of cytochrome P450 (CYP)1A1, CYP1A2, and CYP3A4 but not of CYP2C9, CYP2C19, multidrug resistance (MDR-1) and multidrug resistance associated protein (MRP-1) by prototypical inducers in human hepatocytes.
Topics: Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; beta-Naphthoflavone; Blotting, Western; Cell Size; Cells, Cultured; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Enzyme Induction; Epidermal Growth Factor; Hepatocyte Growth Factor; Humans; Isoenzymes; Liver; Methylcholanthrene; Mixed Function Oxygenases; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Phenobarbital; Rifampin; RNA, Messenger; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Vault Ribonucleoprotein Particles | 2000 |
DNA adducts of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in fetal tissues of patas monkeys after transplacental exposure.
Topics: Animals; beta-Naphthoflavone; Carcinogens; Cytochrome P-450 Enzyme System; DNA Adducts; Dose-Response Relationship, Drug; Erythrocebus; Female; Fetus; Liver; Maternal-Fetal Exchange; Mutagens; Organ Specificity; Phenobarbital; Placenta; Pregnancy; Quinolines | 2000 |
Expression and induction of CYP1A1/1A2, CYP2A6 and CYP3A4 in primary cultures of human hepatocytes: a 10-year follow-up.
Topics: Adult; Aged; beta-Naphthoflavone; Biotransformation; Blotting, Western; Cells, Cultured; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Female; Hepatocytes; Humans; Isoenzymes; Kinetics; Liver; Male; Microsomes, Liver; Middle Aged; Phenacetin; Phenobarbital; Time Factors | 2000 |
Stereoselective metabolism of cibenzoline, an antiarrhythmic drug, by human and rat liver microsomes: possible involvement of CYP2D and CYP3A.
Topics: Animals; Anti-Arrhythmia Agents; Aryl Hydrocarbon Hydroxylases; beta-Naphthoflavone; Cell Line; Chromatography, High Pressure Liquid; Clofibrate; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; Female; Humans; Imidazoles; Ketoconazole; Kinetics; Male; Microsomes; Microsomes, Liver; Oxidoreductases, N-Demethylating; Phenobarbital; Quinidine; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Sex Factors; Stereoisomerism | 2000 |
Cytochrome P450-dependent monooxygenase activities and their inducibility by classic P450 inducers in the liver, kidney, and nasal mucosa of male adult ring-necked pheasants.
Topics: Acetone; Animals; beta-Naphthoflavone; Birds; Clofibrate; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Kidney; Microsomes, Liver; Nasal Mucosa; Phenobarbital | 2000 |
Effects of model inducers on thyroxine UDP-glucuronosyl-transferase activity in vitro in rat and mouse hepatocyte cultures.
Topics: Animals; beta-Naphthoflavone; Cells, Cultured; Clofibric Acid; Enzyme Induction; Glucuronosyltransferase; Hepatocytes; Male; Mice; Mice, Inbred Strains; Monosaccharide Transport Proteins; Phenobarbital; Rats; Rats, Sprague-Dawley | 2000 |
CYP isoform induction screening in 96-well plates: use of 7-benzyloxy-4-trifluoromethylcoumarin as a substrate for studies with rat hepatocytes.
Topics: Animals; beta-Naphthoflavone; Clofenapate; Coumarins; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Glucocorticoids; Glucuronic Acid; Isoenzymes; Isoniazid; Kinetics; Liver; Male; Phenobarbital; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Substrate Specificity; Sulfates | 2000 |
Morphology and cytochrome P450 isoforms expression in precision-cut rat liver slices.
Topics: Animals; Anti-Inflammatory Agents; Anticonvulsants; beta-Naphthoflavone; Cells, Cultured; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Enzyme Inhibitors; Glycogen; Isoenzymes; Liver; Male; Phenobarbital; Rats | 2001 |
Optimization of an exogenous metabolic activation system for FETAX. I. Post-isolation rat liver microsome mixtures.
Topics: 2-Acetylaminofluorene; Abnormalities, Drug-Induced; Animals; beta-Naphthoflavone; Biotransformation; Chlorodiphenyl (54% Chlorine); Coumarins; Cyclophosphamide; Embryo, Mammalian; Embryo, Nonmammalian; Isoniazid; Microsomes, Liver; Phenobarbital; Rats; Toxicity Tests; Trichloroethylene; Xenopus laevis | 2001 |
Optimization of an exogenous metabolic activation system for FETAX. II. Preliminary evaluation.
Topics: Abnormalities, Drug-Induced; Animals; beta-Naphthoflavone; Biotransformation; Carbon Tetrachloride; Chloroform; Coculture Techniques; Embryo, Mammalian; Embryo, Nonmammalian; Isoniazid; Microsomes, Liver; Parathion; Phenacetin; Phenobarbital; Rats; Toxicity Tests; Urethane; Xenopus laevis | 2001 |
Para-nitrophenol glucuronidation and sulfation in rat and human liver slices.
Topics: Animals; beta-Naphthoflavone; Chromatography, High Pressure Liquid; Glucuronates; Humans; In Vitro Techniques; Liver; Male; Nitrophenols; Phenobarbital; Rats; Rats, Wistar; Species Specificity; Sulfates; Time Factors | 2001 |
Induction by xenobiotics of phase I and phase II enzyme activities in the human keratinocyte cell line NCTC 2544.
Topics: Benzoflavones; beta-Naphthoflavone; Cell Line; Dose-Response Relationship, Drug; Enzyme Induction; Humans; Inactivation, Metabolic; Keratinocytes; Methylcholanthrene; Metyrapone; Oxidoreductases; Phenobarbital; Xenobiotics | 2001 |
Evidence supporting the interaction of CYP2B4 and CYP1A2 in microsomal preparations.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzphetamine; beta-Naphthoflavone; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; In Vitro Techniques; Isoenzymes; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Rabbits; Steroid Hydroxylases | 2001 |
Expression and inducibility of cytochrome P450 isoforms in 1-year-old intrasplenic liver cell transplants in rats.
Topics: Animals; beta-Naphthoflavone; Cell Transplantation; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Isoenzymes; Liver; Liver Transplantation; Male; Phenobarbital; Rats; Rats, Inbred F344; Spleen; Time Factors; Transplantation, Heterologous | 2002 |
Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes.
Topics: Aryl Hydrocarbon Hydroxylases; beta-Naphthoflavone; Blotting, Western; Cells, Cultured; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Hepatocytes; Humans; Isoniazid; Liver; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Phenobarbital; Rifampin | 2003 |
Studies on the induction of rat hepatic CYP1A, CYP2B, CYP3A and CYP4A subfamily form mRNAs in vivo and in vitro using precision-cut rat liver slices.
Topics: Animals; beta-Naphthoflavone; Chlorodiphenyl (54% Chlorine); Clofenapate; Culture Techniques; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; DNA Primers; Enzyme Induction; Isoenzymes; Liver; Male; Oligonucleotide Probes; Organ Size; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2003 |
Influence of propiverine on hepatic microsomal cytochrome p450 enzymes in male rats.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzilates; beta-Naphthoflavone; Blotting, Western; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Dose-Response Relationship, Drug; Electrophoresis, Gel, Two-Dimensional; Enzyme Activation; Enzyme Inhibitors; Male; Microsomes, Liver; Phenobarbital; Rats | 2003 |
Binding of polychlorinated biphenyls/metabolites to hemoglobin.
Topics: Animals; Benzo(a)pyrene; beta-Naphthoflavone; Biomarkers; Biphenyl Compounds; Erythrocytes; Female; Globins; Hemoglobins; Humans; Mice; Mice, Inbred C57BL; Phenobarbital; Polychlorinated Biphenyls | 2003 |
Influence of recipient gender on cytochrome P450 isoforms expression in intrasplenic fetal liver tissue transplants in rats.
Topics: Animals; beta-Naphthoflavone; Body Weight; Cell Transplantation; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Female; Glucocorticoids; Immunohistochemistry; Isoenzymes; Liver; Liver Transplantation; Male; Organ Size; Phenobarbital; Rats; Rats, Inbred F344; Sex Factors; Spleen | 2003 |
Induction of P450 monooxygenases in the German cockroach, Blattella germanica L.
Topics: Acetone; Animals; Benzene Derivatives; beta-Naphthoflavone; Blattellidae; Cytochrome P-450 Enzyme System; Cytochromes b5; Enzyme Induction; Ethanol; Isoenzymes; Male; Methylcholanthrene; Mixed Function Oxygenases; Phenobarbital; RNA, Messenger | 2003 |
Upregulation of cytochromes P450 2B in rat liver by orphenadrine.
Topics: Animals; beta-Naphthoflavone; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Dimethyl Sulfoxide; Enzyme Induction; Gene Expression Regulation; Injections, Intraperitoneal; Male; Microsomes, Liver; Orphenadrine; Phenobarbital; Protein Biosynthesis; Rats; Rats, Wistar; Up-Regulation | 2003 |
Roles of human CYP2A6 and 2B6 and rat CYP2C11 and 2B1 in the 10-hydroxylation of (-)-verbenone by liver microsomes.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; beta-Naphthoflavone; Bicyclic Monoterpenes; Cell Line; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP2B1; Cytochrome P-450 CYP2B6; Cytochrome P450 Family 2; Enzyme Activation; Enzyme Induction; Female; Gene Expression; Humans; Hydroxylation; Male; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxidoreductases, N-Demethylating; Phenobarbital; Pregnenolone; Rats; Rats, Sprague-Dawley; Species Specificity; Stereoisomerism; Steroid 16-alpha-Hydroxylase; Terpenes | 2003 |
Evaluation of 2-year-old intrasplenic fetal liver tissue transplants in rats.
Topics: Animals; beta-Naphthoflavone; Biomarkers, Tumor; Cell Differentiation; Cell Transformation, Neoplastic; Choristoma; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Fetal Tissue Transplantation; Fetus; Glutathione Transferase; Graft Survival; Hepatocytes; Male; Phenobarbital; Protein Isoforms; Rats; Rats, Inbred F344; Spleen | 2003 |
Comparison of four modulators of drug metabolism as protectants against the hepatotoxicity of the novel antitumor drug yondelis (ET-743) in the female rat and in hepatocytes in vitro.
Topics: Acetylcysteine; Alkaline Phosphatase; Animals; Antineoplastic Agents, Alkylating; Aspartate Aminotransferases; beta-Naphthoflavone; Cell Survival; Chemical and Drug Induced Liver Injury; Dexamethasone; Dioxoles; Female; Hepatocytes; Inactivation, Metabolic; Isoquinolines; Liver; Phenobarbital; Rats; Rats, Wistar; Tetrahydroisoquinolines; Trabectedin | 2004 |
In vitro metabolism and inductive or inhibitive effect of DL111 on rat cytochrome P4501A enzyme.
Topics: Abortifacient Agents, Nonsteroidal; Animals; beta-Naphthoflavone; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A1; Dexamethasone; Dose-Response Relationship, Drug; Drug Therapy, Combination; Enzyme Induction; Enzyme Inhibitors; Female; Microsomes, Liver; Phenobarbital; Rats; Rats, Sprague-Dawley; Triazoles | 2004 |
Influence of recipient gender on intrasplenic fetal liver tissue transplants in rats: cytochrome P450-mediated monooxygenase functions.
Topics: Animals; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Female; Fetal Tissue Transplantation; Isoenzymes; Liver; Liver Transplantation; Male; Phenobarbital; Rats; Rats, Inbred F344; Sex Factors; Spleen | 2004 |
Effects of beta-naphthoflavone, phenobarbital and dichlobenil on the drug-metabolizing system of liver and nasal mucosa of Italian water frogs.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Aryl Hydrocarbon Hydroxylases; beta-Naphthoflavone; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; DNA Primers; Electrophoresis, Polyacrylamide Gel; Fresh Water; Immunoblotting; Immunohistochemistry; Italy; Liver; Mixed Function Oxygenases; Nasal Mucosa; Nitriles; Oxidoreductases; Phenobarbital; Rana esculenta; Reverse Transcriptase Polymerase Chain Reaction; RNA; Water Pollutants, Chemical | 2004 |
Determination of the sulphoxides and sulphones of three simple sulphides in rat urine: effects of phenobarbitone, beta-naphthoflavone and methimazole.
Topics: Animals; beta-Naphthoflavone; Chlorobenzenes; Chromatography, Gas; Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Male; Methimazole; Mixed Function Oxygenases; Oxidation-Reduction; Phenobarbital; Rats; Rats, Wistar; Sulfides; Sulfones; Sulfoxides | 2005 |
Histomorphological changes and cytochrome P450 isoforms expression and activities in precision-cut liver slices from neonatal rats.
Topics: Animals; Animals, Newborn; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Enzyme Inhibitors; Female; Hepatocytes; Histocytochemistry; Isoenzymes; Liver; Male; Mixed Function Oxygenases; Phenobarbital; Pregnenolone Carbonitrile; Rats | 2005 |
An in vivo and in vitro comparison of CYP induction in rat liver and intestine using slices and quantitative RT-PCR.
Topics: Animals; Base Sequence; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Dexamethasone; DNA Primers; Enzyme Induction; In Vitro Techniques; Intestines; Liver; Male; Phenobarbital; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2004 |
Selectivity of 7-alkoxycoumarins as probe substrates for rat hepatic cytochrome P450 forms is influenced by the substitution pattern on the coumarin nucleus.
Topics: 7-Alkoxycoumarin O-Dealkylase; Adolescent; Adult; Aged; Animals; beta-Naphthoflavone; Coumarins; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Female; Humans; In Vitro Techniques; Isoenzymes; Male; Microsomes, Liver; Middle Aged; Molecular Probes; Molecular Structure; Phenobarbital; Rats; Rats, Wistar; Selegiline; Substrate Specificity | 2004 |
Convenient syntheses of dibenzo[c,p]chrysene and its possible proximate and ultimate carcinogens: in vitro metabolism and DNA adduction studies.
Topics: Animals; beta-Naphthoflavone; Carcinogens, Environmental; Chrysenes; DNA Adducts; Liver; Molecular Structure; Neoplasms, Experimental; Phenobarbital; Rats; Rats, Sprague-Dawley | 2005 |
The spectrum of enzymes involved in activation of 2-aminoanthracene varies with the metabolic system applied.
Topics: Animals; Anthracenes; Benzoflavones; beta-Naphthoflavone; Clotrimazole; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Hepatocytes; Liver; Male; Mutagenesis; Mutagenicity Tests; Mutagens; Phenobarbital; Rats; Rats, Wistar; Salmonella typhimurium | 2005 |
An in vivo and in vitro comparison of CYP gene induction in mice using liver slices and quantitative RT-PCR.
Topics: Animals; beta-Naphthoflavone; Biological Assay; Cytochrome P-450 Enzyme System; Dexamethasone; Gene Expression Regulation, Enzymologic; In Vitro Techniques; Liver; Male; Mice; Mice, Inbred Strains; Phenobarbital; RNA, Messenger; Transcriptional Activation | 2006 |
Cytochrome P450 gene induction in rats ex vivo assessed by quantitative real-time reverse transcriptase-polymerase chain reaction (TaqMan).
Topics: Animals; Aryl Hydrocarbon Hydroxylases; beta-Naphthoflavone; Catalysis; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; Drug Evaluation, Preclinical; Enzyme Induction; Liver; Male; Phenobarbital; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Taq Polymerase | 2006 |
Temporal kinetics and concentration-response relationships for induction of CYP1A, CYP2B, and CYP3A in primary cultures of beagle dog hepatocytes.
Topics: Animals; beta-Naphthoflavone; Cells, Cultured; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dogs; Dose-Response Relationship, Drug; Enzyme Induction; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Hepatocytes; Kinetics; Male; Phenobarbital; Rifampin; RNA, Messenger; Species Specificity | 2006 |
In vitro investigations on the differential pro-oxidant and/or antioxidant properties of cyclosporin A and tacrolimus in human and rat liver microsomes.
Topics: Animals; Antioxidants; beta-Naphthoflavone; Cyclosporine; Cytochrome P-450 Enzyme System; Dexamethasone; Dose-Response Relationship, Drug; Enzyme Induction; Humans; Hydrogen Peroxide; Immunosuppressive Agents; In Vitro Techniques; Isoenzymes; Lipid Peroxidation; Liver; Male; Microsomes, Liver; Oxidants; Phenobarbital; Rats; Rats, Wistar; Tacrolimus | 2006 |
Development of three parallel cytochrome P450 enzyme affinity detection systems coupled on-line to gradient high-performance liquid chromatography.
Topics: Animals; beta-Naphthoflavone; Chromatography, High Pressure Liquid; Coumarins; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enzyme Induction; Enzyme Inhibitors; Flow Injection Analysis; Liver; Microsomes, Liver; Oxazines; Phenobarbital; Rats; Reproducibility of Results; Substrate Specificity; Time Factors | 2007 |
Standardization of the perchlorate discharge assay for thyroid toxicity testing in rats.
Topics: Animals; beta-Naphthoflavone; Chlorodiphenyl (54% Chlorine); Hyperplasia; Hypertrophy; Iodine Radioisotopes; Male; Perchlorates; Phenobarbital; Potassium Compounds; Potassium Iodide; Propylthiouracil; Rats; Rats, Wistar; Reproducibility of Results; Sensitivity and Specificity; Thyroid Function Tests; Thyroid Gland; Thyrotropin; Thyroxine; Toxicity Tests; Triiodothyronine | 2007 |
Precision-cut liver slices from rats of different ages: basal cytochrome P450-dependent monooxygenase activities and inducibility.
Topics: Aging; Animals; Anti-Inflammatory Agents; beta-Naphthoflavone; Coumarins; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Dexamethasone; Dimethyl Sulfoxide; Enzyme Induction; Enzyme Inhibitors; Hydroxylation; Liver; Male; Mixed Function Oxygenases; Organ Culture Techniques; Oxazines; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Wistar; Testosterone; Time Factors | 2008 |
Strain differences in hepatic cytochrome P450 1A and 3A expression between Sprague-Dawley and Wistar rats.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; beta-Naphthoflavone; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP3A; Cytochromes; Dexamethasone; Gene Expression Regulation, Enzymologic; Hepatocytes; Liver; Male; Membrane Proteins; Microsomes, Liver; Phenobarbital; Rats; Rats, Sprague-Dawley; Rats, Wistar; RNA, Messenger; Species Specificity | 2008 |
Temporal evaluation of CYP mRNA in mice administered with prototypical P450 inducers: comparison with conventional protein/enzyme methods.
Topics: Animals; beta-Naphthoflavone; Clofibrate; Cytochrome P-450 Enzyme System; Dexamethasone; Drug Evaluation, Preclinical; Enzyme Induction; Feasibility Studies; Isoenzymes; Liver; Male; Mice; Phenobarbital; Reproducibility of Results; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors | 2008 |
Follow-up to the pre-validation of a harmonised protocol for assessment of CYP induction responses in freshly isolated and cryopreserved human hepatocytes with respect to culture format, treatment, positive reference inducers and incubation conditions.
Topics: Adult; Aged; Antibiotics, Antitubercular; beta-Naphthoflavone; Cell Culture Techniques; Cell Separation; Cryopreservation; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Female; Follow-Up Studies; Hepatocytes; Humans; Indicators and Reagents; Isoenzymes; Male; Middle Aged; Omeprazole; Phenobarbital; Proton Pump Inhibitors; Reference Standards; Rifampin; RNA, Messenger; Young Adult | 2010 |
Induced expression of drug metabolizing enzymes by preventive agents: role of the antioxidant response element.
Topics: Allyl Compounds; Animals; Anticarcinogenic Agents; Antioxidants; beta-Naphthoflavone; Enzyme Induction; Ethoxyquin; Female; Gene Expression Regulation; Glutathione Transferase; Liver; NAD(P)H Dehydrogenase (Quinone); Oligonucleotide Array Sequence Analysis; Phenobarbital; Rats; Rats, Sprague-Dawley; Response Elements; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfhydryl Compounds; Sulfides; Thiones; Thiophenes | 2009 |
A multi-endpoint evaluation of cytochrome P450 1A2, 2B6 and 3A4 induction response in human hepatocyte cultures after treatment with β-naphthoflavone, phenobarbital and rifampicin.
Topics: Aryl Hydrocarbon Hydroxylases; beta-Naphthoflavone; Biological Assay; Blotting, Western; Cells, Cultured; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Endpoint Determination; Enzyme Induction; Hepatocytes; Humans; Oxidoreductases, N-Demethylating; Phenobarbital; Reverse Transcriptase Polymerase Chain Reaction; Rifampin; RNA, Messenger; Substrate Specificity; Time Factors | 2010 |
Homology modeling and molecular dynamics of CYP1A1 and CYP2B1 to explore the metabolism of aryl derivatives by docking and experimental assays.
Topics: Amino Acid Sequence; Animals; beta-Naphthoflavone; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Gas Chromatography-Mass Spectrometry; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Molecular Sequence Data; Phenobarbital; Rats; Sequence Homology, Amino Acid | 2010 |
Expression and inducibility of UDP-glucuronosyltransferase 1As in MCF-7 human breast carcinoma cells.
Topics: beta-Naphthoflavone; Breast Neoplasms; Cell Line, Tumor; Dexamethasone; Enzyme Induction; Female; Gene Expression Regulation, Enzymologic; Glucuronosyltransferase; Humans; Microsomes; Phenobarbital; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2012 |
Different profiles of hepatic alkoxyresorufin O-dealkylase activities in small rodents.
Topics: Animals; beta-Naphthoflavone; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Female; Guinea Pigs; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred ICR; Phenobarbital; Rats; Rats, Sprague-Dawley; Rats, Wistar; Species Specificity | 2012 |
Interleukins-12 and -23 do not alter expression or activity of multiple cytochrome P450 enzymes in cryopreserved human hepatocytes.
Topics: beta-Naphthoflavone; C-Reactive Protein; Cells, Cultured; Cytochrome P-450 Enzyme System; Gene Expression; Hepatocytes; Humans; Interleukin-12; Interleukin-23; Interleukin-6; Liver; Phenobarbital; Receptors, Interleukin; Receptors, Interleukin-12; Rifampin; Tumor Necrosis Factor-alpha | 2013 |
Muscone Induces CYP1A2 and CYP3A4 Enzyme Expression in L02 Human Liver Cells and CYP1A2 and CYP3A11 Enzyme Expression in Kunming Mice.
Topics: Animals; beta-Naphthoflavone; Cells, Cultured; Cycloparaffins; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inducers; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inducers; Dose-Response Relationship, Drug; Gene Expression; Hepatocytes; Humans; Male; Membrane Proteins; Mice; Phenobarbital | 2017 |
Effect of the metabolic capacity in rat liver S9 on the positive results of in vitro micronucleus tests.
Topics: Animals; beta-Naphthoflavone; Cell Line; Cricetulus; Cytochrome P-450 Enzyme System; Liver; Male; Micronucleus Tests; Mutagens; Phenobarbital; Rats, Sprague-Dawley | 2019 |