phenobarbital has been researched along with benzphetamine in 72 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 61 (84.72) | 18.7374 |
| 1990's | 6 (8.33) | 18.2507 |
| 2000's | 3 (4.17) | 29.6817 |
| 2010's | 2 (2.78) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Hunter, AL; Neal, RA | 1 |
| Kicha, LP; Strickhart, FS; Yang, CS | 2 |
| Coon, MJ; Oprian, DD; Vatsis, KP | 1 |
| Baird, MB; Birnbaum, LS | 1 |
| Coon, MJ; Dean, WL | 1 |
| Guengerich, FP | 1 |
| Imai, Y; Iyanagi, T; Sato, R | 1 |
| Marietta, MP; Trevor, AJ; Vore, ME; Way, WL | 1 |
| Hirata, M; Lindeke, B; Orrenius, S | 1 |
| Cederbaum, AI; Cohen, G; Lu, AY; Miwa, G | 1 |
| Dalvi, RR; Peeples, A | 1 |
| Conney, AH; Kuntzman, R; Levin, W; Lu, AY; Ryan, D; West, Sk | 1 |
| Belcher, DH; Kamataki, T; Neal, RA | 1 |
| Friedrich, J; Jänig, GR; Rein, H; Ristau, O; Ruckpaul, K | 1 |
| Levin, W; Lu, AY; Miwa, GT; Ryan, D; Thomas, PE; West, SB | 1 |
| Adams, HR; Isaacson, EL; Masters, BS | 1 |
| Jänig, GR; Mohr, P; Renneberg, R; Ruckpaul, K; Scheller, F | 1 |
| Levin, W; Lu, AY; Ryan, D; West, S | 1 |
| Coon, MJ; Haugen, DA; van der Hoeven, TA | 1 |
| Franklin, MR; James, RC | 1 |
| Kawalek, J; Levin, L; Lu, YH; Ryan, D; West, SB | 1 |
| Dus, K; Litchfield, WJ; Miguel, AG | 1 |
| Drew, RT; Gupta, BN; Harper, C; Talley, FA | 1 |
| Holscher, M; Mgbodile, MU; Neal, RA | 1 |
| Archakov, AI; Bachmanova, GI; Dedinskii, IR; Guleva, IV; Kanaeva, IP; Koen, YM; Krainev, AG; Kuznetsova, GP; Sevryukova, IF; Skotselyas, ED | 1 |
| Kaneko, H; Oguri, K; Takeuchi, K; Yamada, H; Yoshimura, H | 1 |
| Crankshaw, DL; Erickson, RR; Holtzman, JL | 1 |
| Fujino, T; Gelboin, HV; Park, SS; West, D | 1 |
| Heubel, F; Netter, KJ; Vesell, ES | 1 |
| Ardies, CM; Lasker, JM; Lieber, CS | 1 |
| Cooper, DY; Huang, R; Sloviter, HA | 1 |
| Gorsky, LD; Halpert, JR; Miller, NE | 1 |
| Jacobson, M; Kuntzman, R; Levin, W; Lu, AY; McCay, PB; Poyer, JL | 1 |
| Neal, RA; Norman, BJ; Poore, RE | 1 |
| Estabrook, RW; Hrycay, EG | 1 |
| Strickhart, FS; Yang, CS | 1 |
| Conney, AH; Jacobson, M; Kuntzman, R; Levin, W; Lu, AY; Ryan, D; West, S | 1 |
| Blumberg, WE; Levin, W; Lu, AY; Peisach, J; Stern, JO | 1 |
| Burke, MD; Estabrook, RW; Matsubara, T; Prough, RA | 1 |
| Kuntzman, R; Levin, W; Lu, AY | 1 |
| Coon, MJ; Lu, AY; Strobel, HW | 1 |
| Fouts, JR; Peters, MA | 2 |
| Diaugustine, RP; Eling, TE; Fouts, JR | 1 |
| Conney, AH; Jacobson, M; Kuntzman, R; Levin, W; Lu, AY; Ryan, D; West, SB | 1 |
| Jacobson, M; Kuntzman, R; Levin, W; Lu, AY; West, SB | 1 |
| Anders, MW | 1 |
| Conney, AH; Kuntzman, R; Levin, W; Lu, AY; Ryan, D; West, S | 1 |
| Chhabra, RS; Fouts, JR | 1 |
| Levin, W; Lu, AY | 1 |
| Neal, RA; Roth, JA | 1 |
| Fouts, JR; Kutt, H; Waters, L | 2 |
| Fouts, JR; Hewick, DS | 1 |
| Potrepka, RF; Spratt, JL | 1 |
| Backes, WL; Gibson, GG; Schenkman, JB; Sligar, SG; Tamburini, PP | 1 |
| Branchflower, RV; George, JW; Pohl, LR; Schulick, RD | 1 |
| Ahmad, S; Bhatnagar, RK; Kohli, KK; Mukerji, KG; Venkitasubramanian, TA | 1 |
| Duquette, PH; Holloway, DE; Peterson, FJ; Rivers, JM | 1 |
| Mercurio, SD; Nemeth, AM | 1 |
| Jeffery, EH; Mannering, GJ | 1 |
| Gibson, GG; Orton, TC; Tamburini, PP | 1 |
| Delaforge, M; Ioannides, C; Parke, DV; Phillipson, CE | 1 |
| Hirota, K; Kitada, M; Kitagawa, H; Yamazaki, C | 1 |
| Baker, MT; Ronnenberg, WC; Wang, Y | 1 |
| Baker, MT; Chadam, MV; Ronnenberg, WC | 1 |
| Boyle, SP; Craft, JA | 1 |
| Backes, WL; Cawley, GF; Kelley, RW; Zhang, S | 1 |
| Huang, M; Le, J; Peng, RX; Wang, H | 1 |
1 review(s) available for phenobarbital and benzphetamine
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
71 other study(ies) available for phenobarbital and benzphetamine
| Article | Year |
|---|---|
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Inhibition of hepatic mixed-function oxidase activity in vitro and in vivo by various thiono-sulfur-containing compounds.
Topics: Animals; Benzphetamine; Cytochrome P-450 Enzyme Inhibitors; In Vitro Techniques; Liver; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxidoreductases; Phenobarbital; Rats; Thiones; Time Factors | 1975 |
Interaction between NADPH-cytochrome P-450 reductase and hepatic microsomes.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzphetamine; Catalysis; Coumarins; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Ethyl Ethers; Membrane Proteins; Methylcholanthrene; Microsomes, Liver; NADP; NADPH-Ferrihemoprotein Reductase; Oxidoreductases, N-Demethylating; Oxygenases; Phenobarbital; Rats | 1978 |
Kinetics of reduction of purified liver microsomal cytochrome P-450 in the reconstituted enzyme system studied by stopped flow spectrophotometry.
Topics: Animals; Benzoflavones; Benzphetamine; Cytochrome P-450 Enzyme System; Kinetics; Male; Microsomes, Liver; NADP; Oxidation-Reduction; Phenobarbital; Phospholipids; Rabbits; Spectrophotometry; Time Factors | 1979 |
Induction of hepatic mixed function oxidases in senescent rodents.
Topics: Aging; Animals; Benzopyrene Hydroxylase; Benzphetamine; Biotransformation; Cytochrome P-450 Enzyme System; Cytochromes; Enzyme Induction; Ethylmorphine-N-Demethylase; Liver; Male; Methylcholanthrene; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Oxidoreductases; Phenobarbital; Pregnanolone; Rats | 1978 |
Immunochemical studies on two electrophoretically homogeneous forms of rabbit liver microsomal cytochrome P-450: P-450LM2 and P-450LM4.
Topics: Animals; Antibody Specificity; Antigen-Antibody Reactions; Benzphetamine; Cross Reactions; Cytochrome P-450 Enzyme System; Enzyme Induction; Flavonoids; Goats; Immunoassay; Immunodiffusion; Immunoglobulin Fab Fragments; Microsomes, Liver; Naphthalenes; Oxidation-Reduction; Phenobarbital; Rabbits | 1977 |
Separation and purification of multiple forms of microsomal cytochrome P-450. Activities of different forms of cytochrome P-450 towards several compounds of environmental interest.
Topics: Aflatoxins; Animals; Benzopyrenes; Benzphetamine; Carbamates; Carcinogens; Cytochrome P-450 Enzyme System; Dimethylnitrosamine; Furans; Lung; Male; Methylcholanthrene; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; p-Aminoazobenzene; p-Dimethylaminoazobenzene; Parathion; Phenobarbital; Pyrrolizidine Alkaloids; Rabbits; Rats; Terpenes; Toxins, Biological | 1977 |
Rate-limiting step in the reconstituted microsomal drug hydroxylase system.
Topics: Animals; Benzphetamine; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Cytochromes; Kinetics; Methylcholanthrene; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Rabbits; Spectrophotometry | 1977 |
Characterization of ketamine induction of hepatic microsomal drug metabolism.
Topics: Animals; Benzopyrenes; Benzphetamine; Cytochrome P-450 Enzyme System; In Vitro Techniques; Ketamine; Kinetics; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Pharmaceutical Preparations; Phenobarbital; Rats; Stimulation, Chemical | 1977 |
Cytochrome P450 product complexes and glutathione consumption produced in isolated hepatocytes by norbenzphetamine and its N-oxidized congeners.
Topics: Animals; Benzphetamine; Cytochrome P-450 Enzyme System; Glutathione; In Vitro Techniques; Liver; Oxidation-Reduction; Phenethylamines; Phenobarbital; Rats; Time Factors | 1979 |
Production of hydroxyl radicals and their role in the oxidation of ethanol by a reconstituted microsomal system containing cytochrome P-450 purified from phenobarbital-treated rats.
Topics: Aminopyrine N-Demethylase; Animals; Benzphetamine; Cytochrome P-450 Enzyme System; Ethanol; Free Radicals; Microsomes, Liver; Oxidation-Reduction; Oxidoreductases, N-Demethylating; Phenobarbital; Rats | 1979 |
Toxicologic studies of N-trichloromethylthio-4-cyclohexene-1,2-dicarboximide (captan): its metabolism by rat liver drug-metabolizing enzyme system.
Topics: Aniline Hydroxylase; Animals; Benzphetamine; Biotransformation; Captan; Cytochrome P-450 Enzyme System; Male; Maleates; Microsomes, Liver; Phenobarbital; Proadifen; Rats | 1978 |
Partial purification and separation of multiple forms of cytochrome. P-450 and cytochrome P-448 from rat liver microsomes.
Topics: Animals; Benzopyrenes; Benzphetamine; Carbon Monoxide; Chromatography, DEAE-Cellulose; Cytochrome P-450 Enzyme System; Cytochromes; Epoxide Hydrolases; Ethane; Lipids; Male; Methylcholanthrene; Microsomes, Liver; Multienzyme Complexes; NADPH-Ferrihemoprotein Reductase; Naphthalenes; Nitriles; Oxidation-Reduction; Phenobarbital; Phosphatidylcholines; Rats; Spectrum Analysis; Surface-Active Agents | 1975 |
Studies of the metabolism of diethyl p-nitrophenyl phosphorothionate (parathion) and benzphetamine using an apparently homogeneous preparation of rat liver cytochrome P-450: effect of a cytochrome P-450 antibody preparation.
Topics: Animals; Antibodies; Benzphetamine; Cytochrome P-450 Enzyme System; In Vitro Techniques; Liver; Male; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Parathion; Phenethylamines; Phenobarbital; Rabbits; Rats | 1976 |
Evidence for the existence of a high spin-low spin equilibrium in liver microsomal cytochrome P-450.
Topics: Animals; Benzphetamine; Cytochrome P-450 Enzyme System; Microsomes, Liver; Phenobarbital; Protein Binding; Rabbits; Spectrophotometry; Temperature | 1977 |
Accessibility of cytochrome P450 in microsomal membranes: inhibition of metabolism by antibodies to cytochrome P450.
Topics: Animals; Antibodies; Benzopyrenes; Benzphetamine; Coumarins; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytochromes; In Vitro Techniques; Male; Membranes; Methylcholanthrene; Microsomes, Liver; Morphine Derivatives; Phenobarbital; Rats; Testosterone | 1977 |
Inhibition of hepatic microsomal enzymes by chloramphenicol.
Topics: Animals; Benzphetamine; Chloramphenicol; Cytochrome P-450 Enzyme System; Drug Interactions; Ethylmorphine-N-Demethylase; Hexobarbital; In Vitro Techniques; Male; Mice; Microsomes, Liver; Oxidoreductases, N-Demethylating; Pentobarbital; Phenobarbital | 1977 |
Peroxidatic activity of liver microsomal cytochrome P-450.
Topics: Animals; Benzphetamine; Cytochrome P-450 Enzyme System; Enzyme Induction; Kinetics; Male; Microsomes, Liver; Oxidoreductases, N-Demethylating; Peroxidases; Phenobarbital; Rabbits | 1976 |
Multiple forms of cytochrome P-450 in phenobarbital- and 3-methylcholanthrene-treated rats. Separation and spectral properties.
Topics: Amines; Animals; Benzopyrenes; Benzphetamine; Chromatography, DEAE-Cellulose; Cyanides; Cytochrome P-450 Enzyme System; Hemeproteins; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Protein Binding; Protein Conformation; Rats; Spectrophotometry | 1975 |
Purified liver microsomal cytochrome P-450. Separation and characterization of multiple forms.
Topics: Animals; Anisoles; Benzopyrenes; Benzphetamine; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Electrophoresis, Polyacrylamide Gel; Flavonoids; Hydroxylation; Microsomes, Liver; Molecular Weight; Morphine Derivatives; Phenobarbital; Protein Conformation; Rabbits; Testosterone | 1975 |
Comparisons of the formation of cytochrome P-450 complexes absorbing at 455 nm in rabbit and rat microsomes.
Topics: Amphetamine; Animals; Benzphetamine; Cytochrome P-450 Enzyme System; Dextropropoxyphene; In Vitro Techniques; Male; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Proadifen; Rabbits; Rats | 1975 |
Highly purified cytochrome P-448 and P=450 from rat liver microsomes.
Topics: Animals; Benzopyrenes; Benzphetamine; Carbon Monoxide; Chromatography, DEAE-Cellulose; Chromatography, Ion Exchange; Cytochrome P-450 Enzyme System; Cytochromes; Enzyme Induction; Methylcholanthrene; Microsomes, Liver; Molecular Weight; Oxidation-Reduction; Phenobarbital; Rats; Spectrophotometry | 1975 |
Immunochemical and compositional comparison of cytochrome P-450 cam of Pseudomonas putida and P-450 lm of phenobarbital-induced rabbit liver microsomes.
Topics: Amino Acids; Animals; Antibodies; Benzphetamine; Binding, Competitive; Chemical Phenomena; Chemistry; Cross Reactions; Cyanogen Bromide; Cytochrome P-450 Enzyme System; Hydroxylation; Iodine Radioisotopes; Microsomes, Liver; Molecular Weight; Peptide Fragments; Phenobarbital; Pseudomonas; Rabbits; Radioimmunoassay | 1975 |
Effects of vinyl chloride exposures to rats pretreated with phenobarbital.
Topics: Animals; Benzphetamine; Body Weight; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Environmental Exposure; Liver; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Organ Size; Phenobarbital; Rats; Vinyl Chloride; Vinyl Compounds | 1975 |
A possible protective role for reduced glutathione in aflatoxin B1 toxicity: effect of pretreatment of rats with phenobarbital and 3-methylcholanthrene on aflatoxin toxicity.
Topics: Aflatoxins; Animals; Benzphetamine; Body Weight; Chemical and Drug Induced Liver Injury; Cysteine; Cytochrome P-450 Enzyme System; Drug Interactions; Glutathione; Liver; Male; Maleates; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Necrosis; Phenobarbital; Rats | 1975 |
Comparative study of monomeric reconstituted and membrane microsomal monooxygenase systems of the rabbit liver. I. Properties of NADPH-cytochrome P450 reductase and cytochrome P450 LM2 (2B4) monomers.
Topics: Aniline Compounds; Animals; Benzphetamine; Cytochrome P-450 Enzyme System; Intracellular Membranes; Kinetics; Macromolecular Substances; Microsomes, Liver; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Protein Binding; Rabbits; Spectrophotometry | 1992 |
Tissue-specific expression, induction, and inhibition through metabolic intermediate-complex formation of guinea pig cytochrome P450 belonging to the CYP2B subfamily.
Topics: Amino Acid Sequence; Animals; Benzphetamine; Blotting, Western; Cytochrome P-450 Enzyme System; Enzyme Induction; Ferricyanides; Guinea Pigs; Male; Microsomes, Liver; Molecular Sequence Data; Multigene Family; Phenobarbital; Proadifen; Strychnine | 1992 |
Effect of phenobarbital induction, charcoal treatment and storage on the spectral binding characteristics and NADPH-cytochrome P-450 reductase activity of hepatic microsomes.
Topics: Animals; Benzphetamine; Binding Sites; Charcoal; Enzyme Induction; Ethylmorphine; Male; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Phenobarbital; Rats; Time Factors; Tissue Preservation | 1990 |
Studies on the mechanism of monoclonal antibody inhibition of enzyme activity of phenobarbital-induced cytochrome P-450.
Topics: Animals; Antibodies, Monoclonal; Benzphetamine; Coumarins; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Ethylmorphine; NADH Dehydrogenase; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Rats; Rats, Inbred Strains | 1990 |
Brief maternal deprivation of rats reduces hepatic mixed function oxidase activities.
Topics: Aminopyrine; Animals; Benzphetamine; Biotransformation; Body Weight; Coumarins; Enzyme Induction; Female; Handling, Psychological; Male; Maternal Deprivation; Microsomes, Liver; Mixed Function Oxygenases; Oxazines; Phenobarbital; Rats; Rats, Inbred Strains | 1989 |
Characterization of the cytochrome P-450 monooxygenase system of hamster liver microsomes. Effects of prior treatment with ethanol and other xenobiotics.
Topics: Animals; Benzoflavones; Benzphetamine; beta-Naphthoflavone; Cricetinae; Cytochrome P-450 Enzyme System; Ethanol; Isoniazid; Male; Mesocricetus; Microsomes, Liver; Molecular Weight; Oxidation-Reduction; Oxygenases; Phenobarbital; Species Specificity | 1987 |
Effects of intravenous emulsified perfluorochemicals on hepatic cytochrome P-450.
Topics: Animals; Benzphetamine; Blood Substitutes; Cytochrome P-450 Enzyme System; Emulsions; Fluorocarbons; Injections, Intravenous; Liver; Male; Microsomes, Liver; Organ Size; Phenobarbital; Rats | 1987 |
On the mechanism of the inactivation of the major phenobarbital-inducible isozyme of rat liver cytochrome P-450 by chloramphenicol.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Benzphetamine; Chloramphenicol; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Isoenzymes; Kinetics; Male; NADPH-Ferrihemoprotein Reductase; Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains; Spectrophotometry; Time Factors | 1985 |
Lipid peroxidation and the degradation of cytochrome P-450 heme.
Topics: Aminopyrine; Animals; Benzopyrenes; Benzphetamine; Carbon Monoxide; Chromatography, Paper; Chromatography, Thin Layer; Cytochrome P-450 Enzyme System; Levulinic Acids; Lipid Metabolism; Male; Methylcholanthrene; Microsomes, Liver; NADP; Oxidation-Reduction; Pentobarbital; Peroxidases; Phenobarbital; Protein Binding; Rats; Secobarbital; Spectrophotometry; Time Factors; Tritium | 1973 |
Studies of the binding of sulfur released in the mixed-function oxidase-catalyzed metabolism of diethyl p-nitrophenyl phosphorothionate(parathion) to diethyl p-nitrophenyl phosphate (paraoxon).
Topics: Animals; Benzphetamine; Carbon Monoxide; Carbon Radioisotopes; Cytochrome P-450 Enzyme System; Dealkylation; Esterases; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; NADP; Oxidoreductases; Paraoxon; Parathion; Phenobarbital; Solvents; Sulfur; Sulfur Radioisotopes | 1974 |
The effect of extra bound cytochrome b-5 on cytochrome P-450-dependent enzyme activities in liver microsomes.
Topics: Anaerobiosis; Animals; Benzphetamine; Carbon Monoxide; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Cytochromes; Kinetics; Male; Microsomes, Liver; NADH, NADPH Oxidoreductases; NADP; Oxidation-Reduction; Oxidoreductases, N-Demethylating; Peroxidases; Phenobarbital; Rabbits; Spectrophotometry; Spectrophotometry, Ultraviolet; Time Factors; Ultracentrifugation | 1974 |
Inhibition of hepatic mixed function oxidase activity by propyl gallate.
Topics: Aging; Aminopyrine N-Demethylase; Animals; Benzopyrenes; Benzphetamine; Cytochrome c Group; Cytochrome P-450 Enzyme Inhibitors; Cytochrome Reductases; Diet; Gallic Acid; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Methyltransferases; Microsomes, Liver; Mixed Function Oxygenases; Morphinans; NADP; Oxidoreductases; Phenobarbital; Rats; Spectrophotometry, Ultraviolet | 1974 |
The role of cytochrome P-450 and P-448 in drug and steroid hydroxylations.
Topics: Age Factors; Aniline Compounds; Animals; Benzopyrenes; Benzphetamine; Cytochrome P-450 Enzyme System; Cytochromes; Enzyme Induction; Hydroxylation; In Vitro Techniques; Methylcholanthrene; Microsomes, Liver; Morphine Derivatives; Pentobarbital; Phenobarbital; Piperazines; Rats; Testosterone | 1973 |
A low-temperature EPR study of partially purified, soluble ferric cytochromes P-450 and P-448 from rat liver microsomes.
Topics: Animals; Benzopyrenes; Benzphetamine; Cytochrome P-450 Enzyme System; Cytochromes; Electron Spin Resonance Spectroscopy; Guanidines; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Spectrophotometry | 1973 |
The preparation of microsomal fractions of rodent respiratory tract and their characterization.
Topics: Animals; Benzopyrenes; Benzphetamine; Biphenyl Compounds; Cell Fractionation; Centrifugation; Cytochrome P-450 Enzyme System; Cytochromes; Electron Transport Complex IV; Enzyme Induction; Lung; Male; Methylcholanthrene; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; NAD; Oxidation-Reduction; Oxidoreductases; Phenobarbital; Rats; Spectrophotometry, Ultraviolet | 1974 |
Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds and endogenous substrates. VII. Stimulation of benzphetamine N-demethylation by lipid and detergent.
Topics: Animals; Benzphetamine; Cholic Acids; Chromatography, DEAE-Cellulose; Chromatography, Gel; Cytochrome c Group; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Deoxycholic Acid; Detergents; Enzyme Activation; Lipids; Male; Microsomes, Liver; Oxidoreductases, N-Demethylating; Phenobarbital; Phosphatidylcholines; Polyethylene Glycols; Rats; Solubility; Spectrophotometry, Ultraviolet; Time Factors | 1974 |
Hydroxylation of benzphetamine and other drugs by a solubilized form of cytochrome P-450 from liver microsomes: lipid requirement for drug demethylation.
Topics: Aminopyrine; Animals; Appetite Depressants; Benzphetamine; Cytochromes; Depression, Chemical; Ethers; Fatty Acids; Formaldehyde; Hexobarbital; Lipid Metabolism; Liver; Microsomes; Mixed Function Oxygenases; Morphinans; NADP; Oxidoreductases; Phenethylamines; Phenobarbital; Propylamines; Rabbits; Spectrophotometry | 1969 |
A study of some possible mechanisms by which magnesium activates hepatic microsomal drug metabolism in vitro.
Topics: Aniline Compounds; Animals; Benzphetamine; Chlortetracycline; Cytochromes; Electron Transport; In Vitro Techniques; Magnesium; Male; Microsomes, Liver; NADP; Oxidoreductases; Phenobarbital; Rats | 1970 |
The influence of magnesium and some other divalent cations on hepatic microsomal drug metabolism in vitro.
Topics: Aminopyrine; Aniline Compounds; Animals; Benzphetamine; Calcium; Chlorides; Cobalt; Copper; Cytochromes; Edetic Acid; Hexobarbital; In Vitro Techniques; Iron; Magnesium; Male; Manganese; Microsomes, Liver; NADP; Nitrophenols; Phenobarbital; Potassium; Rats; Strontium; Sulfates; Zinc; Zoxazolamine | 1970 |
The interaction of a fluorescent probe with rat hepatic microsomes.
Topics: Aniline Compounds; Animals; Benzphetamine; Binding Sites; Fluorometry; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADP; Naphthalenes; Oxidoreductases; Phenobarbital; Rats; Sulfites; Sulfonic Acids; Warfarin | 1970 |
Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds, and endogenous substrates. VI. Different substrate specificities of the cytochrome P450 fractions from control and phenobarbital-treated rats.
Topics: Aniline Compounds; Animals; Benzopyrenes; Benzphetamine; Chemical Phenomena; Chemistry; Cytochrome P-450 Enzyme System; Dealkylation; Dose-Response Relationship, Drug; Flavonoids; Hemeproteins; Hydroxylation; Lipids; Male; Methylcholanthrene; Microsomes, Liver; Morphinans; Oxidoreductases, N-Demethylating; Pentobarbital; Phenobarbital; Piperazines; Proadifen; Rats; Structure-Activity Relationship; Testosterone | 1973 |
Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds, and endogenous substrates. IV. Hydroxylation of aniline.
Topics: Acetone; Aniline Compounds; Animals; Benzopyrenes; Benzphetamine; Carbon Isotopes; Cytochrome P-450 Enzyme System; Cytochromes; Enzyme Activation; Hydroxylation; Lipids; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Rats; Spectrophotometry | 1972 |
Effect of phenobarbital and 3-methylcholanthrene administration on the in vitro enhancement of microsomal aromatic hydroxylation.
Topics: Acetanilides; Acetone; Aniline Compounds; Animals; Benzphetamine; Hydroxylation; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Protein Binding; Pyridines; Rats; Spectrophotometry; Time Factors | 1972 |
Partial purification and properties of cytochromes P-450 and P-448 from rat liver microsomes.
Topics: Aniline Compounds; Animals; Benzphetamine; Binding Sites; Carbon Isotopes; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Cytochromes; Electrophoresis, Polyacrylamide Gel; Heme; Hexobarbital; Male; Microsomes, Liver; Molecular Weight; Phenobarbital; Phospholipids; Protein Binding; Rats; Sodium Dodecyl Sulfate; Solubility; Spectrophotometry; Spectrophotometry, Ultraviolet; Tritium | 1972 |
Stimulation of hepatic drug-metabolizing enzymes by DDT, polycyclic hydrocarbons or phenobarbital in adrenalectomized or castrated mice.
Topics: Adrenal Glands; Adrenalectomy; Aminopyrine N-Demethylase; Aniline Compounds; Animals; Benzopyrenes; Benzphetamine; Castration; DDT; Dealkylation; Hydrogen-Ion Concentration; Liver; Male; Methylcholanthrene; Methyltransferases; Mice; Mixed Function Oxygenases; Morphinans; Phenobarbital; Polycyclic Compounds; Proteins; Stimulation, Chemical; Testis | 1974 |
Partial purification of cytochromes P-450 and P-448 from rat liver microsomes.
Topics: Ammonium Sulfate; Animals; Benzopyrenes; Benzphetamine; Calcium Phosphates; Carbon Monoxide; Chemical Precipitation; Cytochromes; Gels; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Spectrophotometry | 1972 |
Spectral studies of the binding of O,O-diethyl p-nitrophenylphosphorothionate (parathion) to cytochrome P-450.
Topics: Aminopyrine; Aniline Compounds; Animals; Benzphetamine; Binding Sites; Cytochromes; Hexobarbital; Male; Microsomes, Liver; Morphinans; Parathion; Phenobarbital; Protein Binding; Rabbits; Spectrophotometry | 1972 |
The effects of some stimulators (inducers) of hepatic microsomal drug-metabolizing enzyme activity on substrate-induced difference spectra in rat liver microsomes.
Topics: Aniline Compounds; Animals; Benzphetamine; Carbon Isotopes; DDT; Enzyme Induction; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Phenytoin; Rats; Spectrophotometry | 1971 |
Effects of storage on hepatic microsomal cytochromes and substrate-induced difference spectra.
Topics: Aniline Compounds; Animals; Benzphetamine; Cyanides; Cytochromes; Drug Storage; Enzyme Induction; Heme; Hemoglobins; Hexobarbital; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Male; Methemoglobin; Microsomes, Liver; Phenobarbital; Protein Binding; Rats; Spectrum Analysis; Time Factors | 1970 |
Diphenylhydantoin-induced difference spectra with rat-liver microsomes.
Topics: Animals; Benzphetamine; Chlordan; DDT; Drug Interactions; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Phenytoin; Rats; Rats, Inbred Strains; Spectrum Analysis | 1970 |
Effect of phenobarbital and 3-methylcholanthrene pretreatment on guinea pig hepatic microsomal bilirubin glucuronyltransferase activity.
Topics: Aminopyrine; Aniline Compounds; Animals; Benzphetamine; Bilirubin; Cats; Colorimetry; Enzyme Activation; Glucuronates; Guinea Pigs; Kinetics; Male; Mathematics; Methylcholanthrene; Mice; Microsomes, Liver; Nucleoside Diphosphate Sugars; Phenobarbital; Rabbits; Rats; Species Specificity; Statistics as Topic; Time Factors; Transferases; Uracil Nucleotides | 1971 |
Reduction kinetics of purified rat liver cytochrome P-450. Evidence for a sequential reaction mechanism dependent on the hemoprotein spin state.
Topics: Anaerobiosis; Animals; Benzphetamine; Cytochrome P-450 Enzyme System; Kinetics; Male; Mathematics; Microsomes, Liver; Models, Biological; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Rats; Rats, Inbred Strains; Thermodynamics | 1984 |
Comparison of the effects of methyl-N-butyl ketone and phenobarbital on rat liver cytochromes P-450 and the metabolism of chloroform to phosgene.
Topics: Animals; Benzphetamine; Chloroform; Chromatography, Ion Exchange; Cytochrome P-450 Enzyme System; Ketones; Male; Methyl n-Butyl Ketone; Microsomes, Liver; Phenobarbital; Phosgene; Rats; Rats, Inbred Strains | 1983 |
Induction of polysubstrate monooxygenase and aflatoxin production by phenobarbitone in Aspergillus parasiticus NRRL 3240.
Topics: Aflatoxins; Aspergillus; Benzphetamine; Cytochrome P-450 Enzyme System; Enzyme Induction; Microsomes; NADPH-Ferrihemoprotein Reductase; Phenobarbital | 1982 |
Dietary ascorbic acid and hepatic mixed function oxidase activity in the guinea pig.
Topics: Animals; Ascorbic Acid; Ascorbic Acid Deficiency; Benzphetamine; Cytochrome P-450 Enzyme System; Diet; Dose-Response Relationship, Drug; Enzyme Induction; Guinea Pigs; Kinetics; Liver; Male; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital | 1983 |
Regulation of monooxygenation during development of chick embryo liver: role of cytochrome P-450 isozymes and NADPH.
Topics: Animals; Benzphetamine; Chick Embryo; Codeine; Cytochrome P-450 Enzyme System; Endoplasmic Reticulum; Ethylmorphine; Hydrogen Peroxide; Isoenzymes; Liver; NADP; Phenobarbital; Testosterone | 1983 |
Interaction of constitutive and phenobarbital-induced cytochrome P-450 isozymes during the sequential oxidation of benzphetamine. Explanation for the difference in benzphetamine-induced hydrogen peroxide production and 455-nm complex formation in microsom
Topics: Animals; Benzphetamine; Cytochrome P-450 Enzyme System; Hydrogen Peroxide; Isoenzymes; Kinetics; Male; Microsomes, Liver; Oxidation-Reduction; Phenethylamines; Phenobarbital; Rats; Rats, Inbred Strains | 1983 |
Cytochrome P-450 induction by clofibrate. Purification and properties of a hepatic cytochrome P-450 relatively specific for the 12- and 11-hydroxylation of dodecanoic acid (lauric acid).
Topics: Animals; Benzphetamine; Catalysis; Clofibrate; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Enzyme Induction; Kinetics; Lauric Acids; Liver; Male; Mixed Function Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains | 1982 |
Studies on the substrate-binding sites of liver microsomal cytochrome P-448.
Topics: Animals; Benzphetamine; Binding Sites; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; Ellipticines; Fluorenes; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Safrole; Spectrophotometry; Substrate Specificity | 1982 |
Purification of cytochrome P-450 from liver microsomes of phenobarbital-treated guinea pigs.
Topics: Animals; Benzphetamine; Cytochrome P-450 Enzyme System; Enzyme Induction; Mice; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Phenobarbital; Spectrum Analysis | 1980 |
Isoflurane and cytochrome b5 stimulation of 2-chloro-1,1-difluoroethene metabolism by reconstituted rat CYP2B1 and CYP2C6.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzphetamine; Chlorofluorocarbons; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Cytochromes b5; Fluorides; Isoflurane; Male; Microsomes, Liver; NADP; Phenobarbital; Rabbits; Rats; Rats, Sprague-Dawley; Spectrophotometry, Ultraviolet; Steroid 21-Hydroxylase; Steroid Hydroxylases | 1995 |
Inhibitory effects of propofol on cytochrome P450 activities in rat hepatic microsomes.
Topics: Aniline Compounds; Animals; Benzphetamine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enflurane; Hydroxylation; Isoniazid; Male; Methylation; Microsomes, Liver; Phenobarbital; Propofol; Rats; Rats, Sprague-Dawley; Toluene | 1993 |
The effect of gender, sexual maturation and xenobiotic treatment on the formation of hydroxymethyl metabolites from 7, 12-dimethylbenz[a]anthracene in rat liver microsomes.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzphetamine; Cytochrome P-450 Enzyme System; Female; Hypophysectomy; Isoenzymes; Male; Methylation; Microsomes, Liver; Phenobarbital; Rats; Rats, Long-Evans; Sex Factors; Sexual Maturation; Xenobiotics | 2000 |
Evidence supporting the interaction of CYP2B4 and CYP1A2 in microsomal preparations.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzphetamine; beta-Naphthoflavone; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; In Vitro Techniques; Isoenzymes; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Rabbits; Steroid Hydroxylases | 2001 |
The effect of temperature on monoxygenase reactions in the microsomal membrane.
Topics: Aminopyrine; Animals; Anisoles; Benzphetamine; Catalysis; Cell Membrane; Ethylmorphine; Ethylmorphine-N-Demethylase; Glycerol; Kinetics; Male; Methylation; Microsomes; NADP; NADPH-Ferrihemoprotein Reductase; Oxidoreductases, N-Demethylating; Phenobarbital; Rats; Rats, Long-Evans; Substrate Specificity; Temperature; Time Factors | 1977 |
Influences of 3-methylcholanthrene, phenobarbital and dexamethasone on xenobiotic metabolizing-related cytochrome P450 enzymes and steroidogenesis in human fetal adrenal cortical cells.
Topics: Adrenal Cortex; Aminopyrine N-Demethylase; Benzphetamine; Cells, Cultured; Cytochrome P-450 Enzyme System; Dexamethasone; Fetus; Humans; Methylcholanthrene; Phenobarbital; Pregnenediones; Xenobiotics | 2006 |