phenobarbital and alprenolol

phenobarbital has been researched along with alprenolol in 13 studies

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19907 (53.85)18.7374
1990's0 (0.00)18.2507
2000's4 (30.77)29.6817
2010's2 (15.38)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lüllmann, H; Timmermans, PB; Weikert, GM; Ziegler, A1
Topliss, JG; Yoshida, F1
Caron, G; Ermondi, G1
Lombardo, F; Obach, RS; Waters, NJ1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Belknap, JK; Riffee, WR; Sheppard, JR; Waddingham, S1
Grudin, R; Moldèus, P; Orrenius, S; Vadi, H1
Berggren, M; Moldéus, P; Vadi, H1
Grundin, R; Moldéus, P; Orrenius, S; Vadi, H1
Borg, KO; Grundin, R; Moldéus, P; Orrenius, S; Skånberg, I; von Bahr, C1
Brodin, A; Nilsson, MI1

Other Studies

13 other study(ies) available for phenobarbital and alprenolol

ArticleYear
Accumulation of drugs by guinea pig isolated atria. Quantitative correlations.
    Journal of medicinal chemistry, 1980, Volume: 23, Issue:5

    Topics: Animals; Chemistry, Pharmaceutical; Electric Stimulation; Guinea Pigs; Humans; In Vitro Techniques; Kinetics; Myocardium; Pharmaceutical Preparations; Protein Binding; Serum Albumin; Solubility; Time Factors

1980
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
    Journal of medicinal chemistry, 2005, May-05, Volume: 48, Issue:9

    Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water

2005
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
Barbiturate dependence in mice: evidence for beta-adrenergic receptor proliferation in brain.
    Research communications in chemical pathology and pharmacology, 1978, Volume: 20, Issue:2

    Topics: Alprenolol; Animals; Barbiturates; Brain; Cell Membrane; Cerebral Cortex; Humans; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Phenobarbital; Propranolol; Receptors, Adrenergic; Receptors, Adrenergic, beta; Substance-Related Disorders

1978
Drug metabolism in isolated rat liver cells.
    Advances in experimental medicine and biology, 1975, Volume: 58, Issue:00

    Topics: Alprenolol; Animals; Biotransformation; Carbon Monoxide; Cells, Cultured; Cytochrome P-450 Enzyme System; Electron Spin Resonance Spectroscopy; Fasting; Glucose; Glucuronates; Imipramine; Lactates; Liver; Methods; Metyrapone; NADP; Oxidation-Reduction; Phenobarbital; Proadifen; Protein Binding; Rats; Rotenone; Spectrum Analysis; Temperature; Tritium

1975
Oxidative and conjugative metabolism of p-nitroanisole and p-nitrophenol in isolated rat liver cells.
    Acta pharmacologica et toxicologica, 1976, Volume: 39, Issue:1

    Topics: Alprenolol; Animals; Anisoles; Ethanol; Glucuronates; Liver; Male; Microsomes, Liver; Nitrophenols; Oxidation-Reduction; Phenobarbital; Pyrazoles; Rats; Rotenone; Sulfates; Vitamin K

1976
A study of drug metabolism linked to cytochrome P-450 in isolated rat-liver cells.
    European journal of biochemistry, 1974, Jul-15, Volume: 46, Issue:2

    Topics: Adenosine Triphosphate; Alprenolol; Animals; Antimycin A; Cell Survival; Cyanides; Cytochrome P-450 Enzyme System; Cytoplasm; Gluconeogenesis; Histocytochemistry; In Vitro Techniques; Lactates; Liver; Malate Dehydrogenase; Male; Metyrapone; Microsomes, Liver; Mitochondria, Liver; NADP; Oxygen Consumption; Pentosephosphates; Phenobarbital; Rats; Rotenone; Spectrophotometry; Starvation; Uncoupling Agents

1974
The possible role of cytochrome P-450 in the liver "first pass elimination" of a beta-receptor blocking drug.
    Acta pharmacologica et toxicologica, 1974, Volume: 35, Issue:3

    Topics: Administration, Oral; Alprenolol; Animals; Biological Availability; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Depression, Chemical; Imipramine; Injections, Intravenous; Liver; Male; Methods; Metyrapone; Microsomes, Liver; Perfusion; Phenobarbital; Proadifen; Rats; Spectrophotometry; Time Factors; Tritium

1974
Rates of transfer of organic protolytic solutes between an aqueous and an organic phase. II. Rates of mass transfer between water and different organic liquids.
    Acta pharmaceutica Suecica, 1973, Volume: 10, Issue:3

    Topics: Alprenolol; Benzene; Chloroform; Cyclohexanes; Ephedrine; Hydrogen-Ion Concentration; Methods; Nortriptyline; Pentobarbital; Phenobarbital; Phenylbutazone; Promazine; Solubility; Solvents; Water

1973