phenobarbital has been researched along with allopurinol in 31 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (45.16) | 18.7374 |
| 1990's | 3 (9.68) | 18.2507 |
| 2000's | 7 (22.58) | 29.6817 |
| 2010's | 7 (22.58) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Duffy, EM; Jorgensen, WL | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Glen, RC; Lowe, R; Mitchell, JB | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Bolt, HM; Kappus, H | 1 |
| Higuchi, T; Nakamura, T; Uchino, H | 1 |
| Lohmann, SM; Miech, RP | 1 |
| Goeptar, AR; Neve, EP; Te Koppele, JM; Vermeulen, NP | 1 |
| Abbott, V; Deloria, LB; Mannering, GJ | 1 |
| Beland, FA; Djurić, Z; Fifer, EK; Howard, PC | 1 |
| Furue, H | 1 |
| Talbot, K; White, RA; Workman, P | 1 |
| Greene, FE; Page, JG; Passananti, GT; Vesell, ES | 1 |
| Passananti, GT; Vessell, ES | 1 |
| Welch, RM | 1 |
| Behrens, BC; Bryan, GT; Ichikawa, M; Wang, CY | 1 |
| Burtin, CJ; Paupe, JR; Saurat, JH; Soubrane, CB | 1 |
| Bukowskyj, M; Munt, PW; Nakatsu, K | 1 |
| Bansal, PC; Higuchi, T; Pitman, IH | 1 |
| Boveris, A; Cutrin, JC; González-Flecha, B | 1 |
| Boucher, JL; Clement, B; Henry, Y; Jousserandot, A; Mansuy, D; Niklaus, B | 1 |
4 review(s) available for phenobarbital and allopurinol
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
[Drug interactions with anticancer agents].
Topics: Allopurinol; Animals; Antineoplastic Agents; Cisplatin; Cyclophosphamide; Doxorubicin; Drug Interactions; Drug Therapy, Combination; Humans; Liver; Methotrexate; Neoplasms; Phenobarbital | 1985 |
Utility of clinical chemical determinations of drug concentrations in biological fluids.
Topics: Adult; Allopurinol; Antipyrine; Ataxia; Chemistry, Clinical; Chromatography, Gas; Coffee; Desipramine; Dicumarol; Drug Antagonism; Drug Synergism; Ethanol; Female; Fluorometry; Half-Life; Humans; Iatrogenic Disease; Male; Mental Disorders; Metabolism; Methods; Middle Aged; Morphine; Nortriptyline; Nystagmus, Pathologic; Pharmaceutical Preparations; Pharmacogenetics; Pharmacology; Phenobarbital; Phenylbutazone; Phenytoin; Pregnancy; Smoking; Spectrophotometry; Twins; Ultraviolet Rays | 1971 |
Theophylline reassessed.
Topics: Acidosis; Aging; Allopurinol; Animals; Anti-Bacterial Agents; Breast Feeding; Bronchodilator Agents; Caffeine; Contraceptives, Oral; Cooking; Cystic Fibrosis; Drug Interactions; Erythromycin; Female; Heart Diseases; Histamine H2 Antagonists; Humans; Hypoxia; Infections; Kinetics; Liver Diseases; Lung Diseases, Obstructive; Maternal-Fetal Exchange; Phenobarbital; Phenytoin; Pregnancy; Respiration Disorders; Sleep; Smoking; Theophylline | 1984 |
27 other study(ies) available for phenobarbital and allopurinol
| Article | Year |
|---|---|
Prediction of drug solubility from Monte Carlo simulations.
Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility | 2000 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Topics: | 2008 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine | 2010 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Irreversible protein binding of norethisterone (norethindrone) epoxide.
Topics: Animals; Cattle; Cytosol; Epoxy Compounds; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; NADP; Norethindrone; Phenobarbital; Protein Binding; Rats; Serum Albumin, Bovine; Xanthine Oxidase | 1976 |
Effects of phenobarbital and endotoxin on the lethality and metabolism of 6-mercaptopurine in male BALB/c mice.
Topics: Animals; Drug Interactions; Endotoxins; Hypoxanthine Phosphoribosyltransferase; Hypoxanthines; Inosine Monophosphate; Liver; Male; Mercaptopurine; Mice; Mice, Inbred BALB C; Microsomes, Liver; Phenobarbital; Sleep; Thionucleotides; Time Factors; Xanthine Oxidase | 1977 |
Theophylline metabolism by the rat liver microsomal system.
Topics: Aldehyde Oxidoreductases; Animals; Cytosol; Female; Half-Life; In Vitro Techniques; Liver; Male; Methylcholanthrene; Microsomes, Liver; Mitochondria, Liver; Phenobarbital; Proadifen; Rats; Theophylline; Time Factors; Xanthine Oxidase | 1976 |
Reductase and oxidase activity of rat liver cytochrome P450 with 2,3,5,6-tetramethylbenzoquinone as substrate.
Topics: Animals; Benzoflavones; Benzoquinones; beta-Naphthoflavone; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Electron Spin Resonance Spectroscopy; Enzyme Induction; Hydrogen Peroxide; Male; Microsomes, Liver; Oxidoreductases; Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains; Spin Labels; Superoxides; Xanthine Oxidase | 1992 |
Role of xanthine oxidase in the interferon-mediated depression of the hepatic cytochrome P-450 system in mice.
Topics: Acetylcysteine; Aldehyde Oxidase; Aldehyde Oxidoreductases; Allopurinol; Allylisopropylacetamide; Animals; Azacitidine; Carboxymethylcellulose Sodium; Cytochrome P-450 Enzyme Inhibitors; Dithiothreitol; Ethylmorphine-N-Demethylase; Interferons; Liver; Male; Mice; Phenobarbital; Poly I-C; Polylysine; Tungsten; Tungsten Compounds; Xanthine Dehydrogenase; Xanthine Oxidase | 1988 |
Oxidative microsomal metabolism of 1-nitropyrene and DNA-binding of oxidized metabolites following nitroreduction.
Topics: Acetylation; Animals; Aroclors; Chlorodiphenyl (54% Chlorine); Chromatography, High Pressure Liquid; DNA; Hydroxylation; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Pyrenes; Rats; Rats, Inbred Strains; Stilbenes; Xanthine Oxidase | 1986 |
CB 1954 revisited. I. Disposition kinetics and metabolism.
Topics: Allopurinol; Animals; Aziridines; Azirines; Biotransformation; Brain; Dogs; Drug Interactions; Kinetics; Male; Metabolic Clearance Rate; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Phenobarbital | 1986 |
Genetic control of drug levels and of the induction of drug-metabolizing enzymes in man: individual variability in the extent of allopurinol and nortriptyline inhibition of drug metabolism.
Topics: Adult; Allopurinol; Aniline Compounds; Animals; Antipyrine; Coffee; Cytochromes; Dicumarol; Ethanol; Female; Half-Life; Humans; Kinetics; Male; Mathematics; Metabolism; Microsomes, Liver; Middle Aged; Mixed Function Oxygenases; Morphinans; Nortriptyline; Oxidoreductases; Pharmacogenetics; Phenobarbital; Phenylbutazone; Pregnancy; Rats; Smoking; Statistics as Topic; Tea; Twins; White People | 1971 |
Drug-protein binding: a method for studying the interactions of drugs with bishydroxycoumarin (dicoumarol) in dogs.
Topics: Allopurinol; Animals; Antipyrine; Blood Coagulation; Dicumarol; Dogs; Drug Interactions; Drug Synergism; Enzyme Induction; Half-Life; Liver; Methods; Oxidoreductases; Phenobarbital; Phenylbutazone; Protein Binding; Prothrombin Time; Time Factors; Tolbutamide | 1973 |
Nitroreduction of 5-nitrofuran derivatives by rat liver xanthine oxidase and reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase.
Topics: Acetamides; Allylisopropylacetamide; Animals; Carbon Radioisotopes; Chromatography, Ion Exchange; Cytochrome c Group; Cytochrome Reductases; Cytosol; Dialysis; Electron Transport; Female; Hydrazines; In Vitro Techniques; Liver; Methylcholanthrene; Microsomes, Liver; Milk; NADP; Nitrofurans; Nitrofurantoin; Oxidation-Reduction; Phenobarbital; Protein Binding; Rats; Thiazoles; Xanthine Oxidase | 1974 |
Cell mediated hypersensitivity in skin reactions to drugs (except contact dermatitis).
Topics: Allopurinol; Ampicillin; Aspirin; Cell Migration Inhibition; Colistin; Dermatitis, Contact; Drug Eruptions; Hemagglutination Tests; Humans; Immunity, Cellular; Immunoglobulin E; Leukocytes; Lymphocyte Activation; Penicillins; Phenobarbital; Quinine; Skin Tests; Sulfonamides; Tetracycline | 1973 |
N-hydroxymethyl derivatives of nitrogen heterocycles as possible prodrugs II: possible prodrugs of allopurinol, glutethimide, and phenobarbital.
Topics: Allopurinol; Chemical Phenomena; Chemistry; Glutethimide; Phenobarbital; Solubility | 1981 |
Time course and mechanism of oxidative stress and tissue damage in rat liver subjected to in vivo ischemia-reperfusion.
Topics: Animals; Free Radicals; Hydrogen Peroxide; Ischemia; Liver; Luminescent Measurements; Male; Mitochondria, Liver; Oxygen Consumption; Phenobarbital; Rats; Rats, Wistar; Reperfusion Injury; Xanthine Dehydrogenase; Xanthine Oxidase | 1993 |
Microsomal cytochrome P450 dependent oxidation of N-hydroxyguanidines, amidoximes, and ketoximes: mechanism of the oxidative cleavage of their C=N(OH) bond with formation of nitrogen oxides.
Topics: Amides; Animals; Aryl Hydrocarbon Hydroxylases; Benzamidines; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Free Radicals; Guanidines; Hydrogen Bonding; Hydroxylamines; Injections, Intraperitoneal; Male; Methylcholanthrene; Microsomes, Liver; Nitrogen Oxides; Oxidation-Reduction; Oximes; Oxygen Isotopes; Phenobarbital; Rabbits; Rats; Rats, Sprague-Dawley; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Xanthine; Xanthine Oxidase | 1998 |