phenobarbital has been researched along with acetylcysteine in 25 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (52.00) | 18.7374 |
| 1990's | 5 (20.00) | 18.2507 |
| 2000's | 5 (20.00) | 29.6817 |
| 2010's | 2 (8.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Moldéus, P; Orrenius, S; Thor, H | 1 |
| Moldéus, P | 1 |
| Mitchell, JR; Timbrell, JA | 1 |
| Chan, HM; Cherian, MG; Tabarrok, R; Tamura, Y | 1 |
| Ignarro, LJ; Wood, KS | 1 |
| Abbott, V; Deloria, LB; Mannering, GJ | 1 |
| Krewet, E; Müller, G; Norpoth, K | 1 |
| Kramer, RA | 1 |
| Kammerer, RC; Lampe, MA | 1 |
| Smith, AG; Stewart, FP | 1 |
| Jollow, DJ; Keiser, H; Mitchell, JR; Potter, WZ; Thorgeirsson, SS | 1 |
| Hashimoto, M; Jollow, DJ; Mitchell, JR; Potter, WZ; Thorgeirsson, SS | 1 |
| Anundi, I; Dawson, JR; Moldéus, P; Norbeck, K | 1 |
| Pflüger, KH | 1 |
| Appenroth, D | 1 |
| Bergelson, S; Daniel, V; Pinkus, R | 1 |
| Hershkovitz, E; Levitas, A; Shorer, Z; Tal, A | 1 |
| Henning, SJ; Jacomino, M; Shukla, P | 1 |
| Bauer, D; Heder, AF; Hirsch-Ernst, KI; Kahl, GF; Schlaefer, K | 1 |
| Chua, SS; Huang, W; Moore, DD; Wei, P; Zhang, J | 1 |
| Donald, S; Gescher, AJ; Greaves, P; Jimeno, J; Orr, S; Verschoyle, RD | 1 |
1 review(s) available for phenobarbital and acetylcysteine
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
24 other study(ies) available for phenobarbital and acetylcysteine
| Article | Year |
|---|---|
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Metabolic activation and hepatotoxicity. Effect of cysteine, N-acetylcysteine, and methionine on glutathione biosynthesis and bromobenzene toxicity in isolated rat hepatocytes.
Topics: Acetylcysteine; Animals; Biotransformation; Bromobenzenes; Cysteine; Glutathione; In Vitro Techniques; Kinetics; Liver; Male; Maleates; Methionine; Microsomes, Liver; Phenobarbital; Rats | 1979 |
Paracetamol metabolism and toxicity in isolated hepatocytes from rat and mouse.
Topics: Acetaminophen; Acetylcysteine; Animals; Cysteine; Glucuronates; Glutathione; In Vitro Techniques; Liver; Male; Mice; Phenobarbital; Rats; Sulfates; Time Factors | 1978 |
Toxicity-related changes in benzene metabolism in vivo.
Topics: Acetylcysteine; Animals; Benzene; Breath Tests; Cobalt; Male; Phenobarbital; Phenols; Piperonyl Butoxide; Rats | 1977 |
The relative importance of glutathione and metallothionein on protection of hepatotoxicity of menadione in rats.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Calcium; Chemical and Drug Induced Liver Injury; Cytosol; Glutathione; In Vitro Techniques; L-Lactate Dehydrogenase; Liver; Male; Metallothionein; Methionine Sulfoximine; Phenobarbital; Potassium; Rats; Rats, Sprague-Dawley; Sulfates; Vitamin K; Zinc; Zinc Sulfate | 1992 |
Hepatic cyclic GMP formation is regulated by similar factors that modulate activation of purified hepatic soluble guanylate cyclase.
Topics: 1-Methyl-3-isobutylxanthine; Acetaminophen; Acetylcysteine; Animals; Cyclic AMP; Cyclic GMP; Guanylate Cyclase; Heme; Liver; Methylnitronitrosoguanidine; Mice; Nitroglycerin; Penicillamine; Phenobarbital; Phenylhydrazines; Potassium Cyanide; Probenecid; Protoporphyrins; Purinones; S-Nitroso-N-Acetylpenicillamine | 1987 |
Role of xanthine oxidase in the interferon-mediated depression of the hepatic cytochrome P-450 system in mice.
Topics: Acetylcysteine; Aldehyde Oxidase; Aldehyde Oxidoreductases; Allopurinol; Allylisopropylacetamide; Animals; Azacitidine; Carboxymethylcellulose Sodium; Cytochrome P-450 Enzyme Inhibitors; Dithiothreitol; Ethylmorphine-N-Demethylase; Interferons; Liver; Male; Mice; Phenobarbital; Poly I-C; Polylysine; Tungsten; Tungsten Compounds; Xanthine Dehydrogenase; Xanthine Oxidase | 1988 |
The excretion of chlorophenylmercapturic acid, chlorophenols and a guanine adduct in the urine of chlorobenzene-treated rats after phenobarbital pretreatment.
Topics: Acetylcysteine; Animals; Chemical Phenomena; Chemistry; Chlorobenzenes; Chlorophenols; Chromatography, Gas; Chromatography, Ion Exchange; Guanine; Male; Mass Spectrometry; Phenobarbital; Rats; Rats, Inbred Strains; Species Specificity; Spectrophotometry, Ultraviolet | 1989 |
Cytochrome P-450-dependent formation of alkylating metabolites of the 2-chloroethylnitrosoureas MeCCNU and CCNU.
Topics: Acetylcysteine; Alkylating Agents; Alkylation; Animals; Biotransformation; Cytochrome P-450 Enzyme System; DNA; Glutathione; Male; Microsomes, Liver; NADP; Phenobarbital; Rats; Rats, Inbred F344; Semustine | 1989 |
Cytochrome P-450 dependent binding of methapyrilene to DNA in vitro.
Topics: Acetylcysteine; Aminopyridines; Animals; Biotransformation; Cattle; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; DNA; Methapyrilene; Methimazole; Metyrapone; Microsomes, Liver; NADP; Phenobarbital; Polychlorinated Biphenyls; Pregnenolone Carbonitrile; Proadifen; Rats; Safrole | 1987 |
Metabolism of the "mixed" cytochrome P-450 inducer hexachlorobenzene by rat liver microsomes.
Topics: Acetylcysteine; Aroclors; Carbon Monoxide; Chlorobenzenes; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Ellipticines; Enzyme Induction; Female; Gas Chromatography-Mass Spectrometry; Glutathione; Hexachlorobenzene; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Molecular Weight; NADP; Pentachlorophenol; Phenobarbital; Polychlorinated Dibenzodioxins; Proadifen; Safrole | 1986 |
Acetaminophen-induced hepatic injury: protective role of glutathione in man and rationale for therapy.
Topics: Acetaminophen; Acetylcysteine; Adult; Amobarbital; Animals; Chemical and Drug Induced Liver Injury; Chromatography, Paper; Cysteamine; Cytochrome P-450 Enzyme System; Desipramine; Dimercaprol; Dose-Response Relationship, Drug; Enzyme Induction; Female; Glutathione; Humans; Indicators and Reagents; Liver; Male; Mass Spectrometry; Methyltransferases; Mice; Microsomes, Liver; Phenobarbital; Protein Binding; Proteins; Sulfhydryl Compounds; Time Factors; Tritium | 1974 |
Acetaminophen-induced hepatic necrosis. VI. Metabolic disposition of toxic and nontoxic doses of acetaminophen.
Topics: Acetaminophen; Acetylcysteine; Animals; Cricetinae; Depression, Chemical; Glutathione; Liver; Mass Spectrometry; Methylcholanthrene; Mice; Necrosis; Phenobarbital; Piperonyl Butoxide; Rats; Species Specificity; Stimulation, Chemical; Tritium | 1974 |
The effectiveness of N-acetylcysteine in isolated hepatocytes, against the toxicity of paracetamol, acrolein, and paraquat.
Topics: Acetaminophen; Acetone; Acetylcysteine; Acrolein; Aldehydes; Amino Acids; Animals; Cell Survival; Chemical and Drug Induced Liver Injury; Glutathione; Liver; Male; Maleates; Paraquat; Phenobarbital; Rats; Rats, Inbred Strains | 1984 |
[Toxicology and therapy of paracetamol poisoning].
Topics: Acetaminophen; Acetylcysteine; Cysteamine; Drug Interactions; Ethanol; Gastric Lavage; Glutathione; Half-Life; Methionine; Phenobarbital; Poisoning | 1980 |
Ontogenic changes in the nephrotoxicity of chromate correlate with the glutathione oxidoreduction system.
Topics: Acetylcysteine; Aging; Animals; Chromates; Female; Glutaredoxins; Glutathione; Kidney; Male; Oxidation-Reduction; Oxidoreductases; Phenobarbital; Protein Disulfide Reductase (Glutathione); Proteinuria; Rats; Sodium Compounds | 1994 |
Phenobarbital induction of AP-1 binding activity mediates activation of glutathione S-transferase and quinone reductase gene expression.
Topics: Acetylcysteine; Animals; Base Sequence; Chloramphenicol O-Acetyltransferase; Gene Expression; Glutathione; Glutathione Transferase; Liver Neoplasms, Experimental; Mice; Molecular Sequence Data; NAD(P)H Dehydrogenase (Quinone); Phenobarbital; Plasmids; Proto-Oncogene Proteins c-jun; Rats; Transfection; Tumor Cells, Cultured | 1993 |
Status epilepticus following intravenous N-acetylcysteine therapy.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Anticonvulsants; Blindness; Child, Preschool; Female; Free Radical Scavengers; Humans; Infusions, Intravenous; Phenobarbital; Status Epilepticus | 1996 |
Use of amphotropic retroviral vectors for gene transfer in human colon carcinoma cells.
Topics: 3T3 Cells; Acetylcysteine; Animals; Caco-2 Cells; Colonic Neoplasms; Culture Media; Gene Transfer Techniques; Genetic Vectors; HT29 Cells; Humans; Mice; Phenobarbital; Rats; Retroviridae; Transformation, Genetic; Tumor Cells, Cultured | 1997 |
Repression of phenobarbital-dependent CYP2B1 mRNA induction by reactive oxygen species in primary rat hepatocyte cultures.
Topics: Acetylcysteine; Amitrole; Animals; Cytochrome P-450 CYP2B1; Drug Interactions; Enzyme Induction; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Gene Expression Regulation, Enzymologic; Gene Silencing; Hepatocytes; Hydrogen Peroxide; In Vitro Techniques; Male; Phenobarbital; Promoter Regions, Genetic; Rats; Rats, Wistar; Reactive Oxygen Species; RNA, Messenger; Transcriptional Activation | 2001 |
Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Androstanols; Animals; Aryl Hydrocarbon Hydroxylases; Benzoquinones; Constitutive Androstane Receptor; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Glutathione; Glutathione S-Transferase pi; Glutathione Transferase; Humans; Imines; Isoenzymes; Liver; Mice; Mice, Knockout; Mice, Transgenic; Oxidoreductases, N-Demethylating; Phenobarbital; Pyridines; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Time Factors; Transcription Factors | 2002 |
Comparison of four modulators of drug metabolism as protectants against the hepatotoxicity of the novel antitumor drug yondelis (ET-743) in the female rat and in hepatocytes in vitro.
Topics: Acetylcysteine; Alkaline Phosphatase; Animals; Antineoplastic Agents, Alkylating; Aspartate Aminotransferases; beta-Naphthoflavone; Cell Survival; Chemical and Drug Induced Liver Injury; Dexamethasone; Dioxoles; Female; Hepatocytes; Inactivation, Metabolic; Isoquinolines; Liver; Phenobarbital; Rats; Rats, Wistar; Tetrahydroisoquinolines; Trabectedin | 2004 |