phenobarbital has been researched along with 4-hydroxyphenobarbital in 35 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (57.14) | 18.7374 |
| 1990's | 11 (31.43) | 18.2507 |
| 2000's | 3 (8.57) | 29.6817 |
| 2010's | 1 (2.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Strassburg, CP; Tukey, RH | 1 |
| Anderson, GD; Levy, RH | 1 |
| Danhof, M; Stijnen, AM; Van Bezooijen, CF | 1 |
| Agriesti, BE; England, TM; Ferkany, JW; Soine, PJ; Soine, WH | 1 |
| England, TM; Soine, PJ; Soine, WH; Welty, DF; Wood, JH | 1 |
| Danhof, M; Dingemanse, J; van Bree, JB | 1 |
| Chianale, J; Dvorak, C; Gumucio, JJ; Keren, D; Traber, PG; Wojcik, E | 1 |
| Champion, L; Escousse, A; Goudonnet, H; Mounié, J; Truchot, RC | 1 |
| Bhargava, VO; Garrettson, LK | 1 |
| Bhargava, VO | 1 |
| Benchekroun, Y; Brazier, JL; Desage, M; Ribon, B | 1 |
| Cooper, DY; Levin, SS; Schleyer, H; Vars, HM | 1 |
| Bhargava, VO; Garrettson, LK; Soine, WH | 1 |
| Danhof, M; Hisaoka, M; Levy, G | 1 |
| Aymard, P; Taburet, AM | 1 |
| Kalow, W; Tang, BK; Yilmaz, B | 1 |
| Cresteil, T; Dansette, PM; Leroux, JP; Mahu, JL | 1 |
| Biemann, K; Biller, JE; Browne, TR; Van Langenhove, A | 1 |
| Kupferberg, HJ; Newmark, ME; Porro, MG; Porter, RJ; Theodore, WH | 1 |
| Kapetanović, IM; Kupferberg, HJ | 1 |
| Batt, AM; Engasser, JM; Magdalou, J; Sarhan, F; Siest, G | 1 |
| Jesdinsky, D; Nau, H; Wittfoht, W | 1 |
| Levy, RH; Neal, JM; Patel, IH; Trager, WF | 1 |
| Albani, F; Baruzzi, A; Riva, R | 1 |
| Chipman, JK; Coleman, R; Guppy, MJ; Sharma, R; Wilton, JC | 1 |
| Banfield, CR; Colucci, RD; Glue, P; Guillaume, M; Lin, CC; Meehan, JW; Mojavarian, P; Nezamis, J; Radwanski, E; Reidenberg, P | 1 |
| Brouwer, KL; Studenberg, SD | 1 |
| Brouwer, KL; Price-Raybuck, DL; Shockcor, J; Studenberg, SD; Unger, SE | 1 |
| André, D; Cavé, C; Davy, J; Farnoux, CC; Lafont, O; Ménager, S; Vérité, P | 1 |
| Paibir, SG; Soine, WH | 1 |
| Chabenat, C; Ferranti, V; Lafont, O; Ménager, S | 1 |
| Chabenat, C; Ferranti, V; Hue, H; Lafont, O; Marchais, H; Ménager, S; Orecchioni, AM | 1 |
| Brouwer, KL; Meier, PJ; Pollack, GM; Sugiyama, Y; Suzuki, H; Xiong, H | 1 |
| Batt, AM; Boutin, JA; Jacquier, A; Marlière, P; Siest, G | 1 |
| Abounassif, M; Al-Ghamdi, A; Attia, S; Hefnawy, M; Julkhuf, S; Kadi, A; Kassem, MG; Mostafa, G | 1 |
1 review(s) available for phenobarbital and 4-hydroxyphenobarbital
| Article | Year |
|---|---|
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic | 2000 |
1 trial(s) available for phenobarbital and 4-hydroxyphenobarbital
| Article | Year |
|---|---|
Effects of felbamate on the pharmacokinetics of phenobarbital.
Topics: Adult; Anticonvulsants; Double-Blind Method; Drug Administration Schedule; Drug Interactions; Felbamate; Glucaric Acid; Humans; Male; Phenobarbital; Phenylcarbamates; Placebos; Propylene Glycols | 1995 |
33 other study(ies) available for phenobarbital and 4-hydroxyphenobarbital
| Article | Year |
|---|---|
The effect of valproate on the metabolism of phenobarbital in the rat.
Topics: Animals; Bile; Chromatography, High Pressure Liquid; In Vitro Techniques; Liver; Male; Phenobarbital; Protein Binding; Rats; Rats, Sprague-Dawley; Valproic Acid | 1992 |
Increased sensitivity to the anesthetic effect of phenobarbital in aging BN/BiRij rats.
Topics: Aging; Animals; Chromatography, High Pressure Liquid; Infusions, Intravenous; Male; Phenobarbital; Rats; Reflex, Abnormal; Tissue Distribution | 1992 |
Identification of phenobarbital N-glucosides as urinary metabolites of phenobarbital in mice.
Topics: Animals; Anticonvulsants; Cats; Dogs; Female; Guinea Pigs; Macaca mulatta; Male; Mice; Mice, Inbred ICR; Motor Activity; Phenobarbital; Rabbits; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Species Specificity; Swine | 1991 |
LC determination of the diastereomers of 1-(beta-D-glucopyranosyl)phenobarbital in human urine.
Topics: Asian People; Chromatography, Liquid; Humans; Phenobarbital; Stereoisomerism; White People | 1990 |
Pharmacokinetic modeling of the anticonvulsant action of phenobarbital in rats.
Topics: Animals; Dose-Response Relationship, Drug; Female; Models, Biological; Pentylenetetrazole; Phenobarbital; Rats; Rats, Inbred Strains; Seizures | 1989 |
Demonstration by in situ hybridization of the zonal modulation of rat liver cytochrome P-450b and P-450e gene expression after phenobarbital.
Topics: Animals; Cytochrome P-450 Enzyme System; Drug Administration Schedule; Enzyme Induction; Fluorescent Antibody Technique; Gene Expression Regulation; Liver; Male; Nucleic Acid Hybridization; Phenobarbital; Rats; RNA, Messenger | 1988 |
Inductive effects of fenofibrate and metabolism of phenobarbital.
Topics: Animals; Body Weight; Cytochrome P-450 Enzyme System; Fenofibrate; In Vitro Techniques; Liver; Male; Microsomes, Liver; Organ Size; Phenobarbital; Propionates; Rats; Rats, Inbred Strains | 1988 |
Development of phenobarbital glucosidation in the human neonate.
Topics: Female; Glucose; Half-Life; Humans; Infant, Newborn; Injections, Intravenous; Male; Phenobarbital; Seizures; Time Factors | 1988 |
Quantitation of 1-(beta-D-glucopyranosyl)phenobarbital in plasma and bile.
Topics: Bile; Chromatography, High Pressure Liquid; Humans; Phenobarbital; Spectrophotometry, Ultraviolet | 1987 |
Simultaneous quantitation of phenobarbitone and p-hydroxyphenobarbitone and their perdeuteroethyl analogues in biological fluids by combined gas chromatography-mass spectrometry.
Topics: Deuterium; Gas Chromatography-Mass Spectrometry; Humans; Phenobarbital | 1987 |
The metabolism and excretion of enzyme-inducing doses of phenobarbital by rats with bile fistulas.
Topics: Animals; Bile; Biliary Fistula; Biotransformation; Cytochrome P-450 Enzyme System; Glucuronates; Liver; Male; Mixed Function Oxygenases; Phenobarbital; Rats; Subcellular Fractions; Tissue Distribution | 1986 |
High-performance liquid chromatographic analysis of 1-(beta-D-glucopyranosyl)phenobarbital in urine.
Topics: Adolescent; Adult; Aged; Chromatography, High Pressure Liquid; Female; Glucuronidase; Humans; Hydrolysis; Male; Phenobarbital | 1985 |
Kinetics of drug action in disease states. II. Effect of experimental renal dysfunction on phenobarbital concentrations in rats at onset of loss of righting reflect.
Topics: Acute Kidney Injury; Animals; Dose-Response Relationship, Drug; Female; Kinetics; Phenobarbital; Posture; Rats; Rats, Inbred Lew; Reflex; Uranyl Nitrate | 1984 |
Valproate glucuronidation by rat liver microsomes. Interaction with parahydroxyphenobarbital.
Topics: Animals; Chromatography, Gas; Glucuronosyltransferase; Kinetics; Male; Microsomes, Liver; Phenobarbital; Protein Binding; Rats; Rats, Inbred Strains; Substrate Specificity; Valproic Acid | 1983 |
Determination of phenobarbital, p-hydroxyphenobarbital and phenobarbital-N-glucoside in urine by gas chromatography chemical ionization mass spectrometry.
Topics: Chemical Phenomena; Chemistry; Gas Chromatography-Mass Spectrometry; Humans; Phenobarbital | 1984 |
In vivo administration of hydroxylated phenobarbital metabolites: effect on rat hepatic cytochromes P-450, epoxide hydrolase and UDP-glucuronosyltransferase.
Topics: Animals; Cytochrome P-450 Enzyme System; Endoplasmic Reticulum; Epoxide Hydrolases; Glucuronosyltransferase; Liver; Male; Microsomes, Liver; Phenobarbital; Rats | 1980 |
Simultaneous determination of phenobarbital and p-hydroxyphenobarbital and their stable isotope labeled analogs by gas chromatography mass spectrometry.
Topics: Carbon Isotopes; Gas Chromatography-Mass Spectrometry; Humans; Nitrogen Isotopes; Phenobarbital | 1982 |
Phenytoin: an inhibitor and inducer of primidone metabolism in an epileptic patient.
Topics: Adult; Drug Interactions; Epilepsy; Female; Humans; Phenobarbital; Phenylethylmalonamide; Phenytoin; Primidone | 1982 |
GC and GC-mass spectrometric determination of p-hydroxyphenobarbital extracted from plasma, urine, and hepatic microsomes.
Topics: Animals; Biotransformation; Chromatography, Gas; Gas Chromatography-Mass Spectrometry; Humans; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Phenobarbital; Primidone; Rats | 1981 |
Effect of diphenylhydantoin and its main hydroxylated metabolite on the pharmacokinetics and the urinary and biliary excretion of phenobarbital and its p-hydroxy metabolite.
Topics: Animals; Bile; Half-Life; Kinetics; Male; Mixed Function Oxygenases; Phenobarbital; Phenytoin; Rats; Rats, Inbred Strains; Tissue Distribution | 1981 |
Microassay for primidone and its metabolites phenylethylmalondiamide, phenobarbital and p-hydroxyphenobarbital in human serum, saliva, breast milk and tissues by gas chromatography--mass spectrometry using selected ion monitoring.
Topics: Female; Gas Chromatography-Mass Spectrometry; Humans; Infant, Newborn; Kinetics; Malonates; Maternal-Fetal Exchange; Microchemistry; Milk, Human; Phenobarbital; Phenylethylmalonamide; Pregnancy; Primidone; Saliva | 1980 |
Simultaneous analysis of phenobarbital and p-hydroxyphenobarbital in biological fluids by GLC-chemical-ionization mass spectrometry.
Topics: Gas Chromatography-Mass Spectrometry; Phenobarbital | 1980 |
Rapid quantitative determination of underivatized carbamazepine, phenytoin, phenobarbital and p-hydroxyphenobarbital in biological fluids by packed column gas chromatography.
Topics: Adult; Carbamazepine; Chromatography, Gas; Epilepsy; Female; Gas Chromatography-Mass Spectrometry; Humans; Male; Middle Aged; Phenobarbital; Phenytoin | 1980 |
Modulation of phenobarbitone-induced loss of gap junctional intercellular communication in hepatocyte couplets.
Topics: Animals; Biotransformation; Cell Communication; Cells, Cultured; Cycloheximide; Cytochrome P-450 Enzyme System; Drug Interactions; Gap Junctions; Glutathione; Liver; Male; Oxidative Stress; Phenobarbital; Rats; Rats, Wistar; Staining and Labeling; Time Factors | 1994 |
Effect of phenobarbital and p-hydroxyphenobarbital glucuronide on acetaminophen metabolites in isolated rat hepatocytes: use of a kinetic model to examine the rates of formation and egress.
Topics: Acetaminophen; Animals; Bile; Extracellular Space; Glucuronates; In Vitro Techniques; Liver; Male; Models, Biological; Phenobarbital; Rats; Rats, Sprague-Dawley; Regression Analysis; Sulfates | 1993 |
Characterization of p-hydroxyphenobarbital glucuronide generated from immobilized rat hepatic UDP-glucuronosyltransferase.
Topics: Animals; Enzymes, Immobilized; Glucuronates; Glucuronosyltransferase; In Vitro Techniques; Liver; Mass Spectrometry; Phenobarbital; Rats; Rats, Sprague-Dawley | 1995 |
Phenobarbital metabolism by hepatocytes isolated from rat.
Topics: Animal Testing Alternatives; Animals; Biotransformation; Calibration; Chromatography, Gas; Female; Gas Chromatography-Mass Spectrometry; Glucuronidase; Hydroxylation; Hypnotics and Sedatives; In Vitro Techniques; Liver; Phenobarbital; Rats; Rats, Sprague-Dawley; Sulfatases | 1996 |
High-performance liquid chromatographic analysis of phenobarbital and phenobarbital metabolites in human urine.
Topics: Adult; Chromatography, High Pressure Liquid; Glucuronates; Humans; Male; Middle Aged; Phenobarbital; Sensitivity and Specificity | 1997 |
Simultaneous determination of primidone and its three major metabolites in rat urine by high-performance liquid chromatography using solid-phase extraction.
Topics: Animals; Anticonvulsants; Chromatography, High Pressure Liquid; Evaluation Studies as Topic; Phenobarbital; Phenylethylmalonamide; Primidone; Rabbits; Rats; Rats, Sprague-Dawley; Reproducibility of Results | 1998 |
Effects of encapsulation of primidone on its oxidative metabolism in rats.
Topics: Animals; Anticonvulsants; Chemical Phenomena; Chemistry, Physical; Drug Compounding; Feces; Female; Nanotechnology; Oxidation-Reduction; Phenobarbital; Phenylethylmalonamide; Polyesters; Primidone; Rats; Rats, Sprague-Dawley | 2001 |
Mechanisms of impaired biliary excretion of acetaminophen glucuronide after acute phenobarbital treatment or phenobarbital pretreatment.
Topics: Acetaminophen; Animals; Bile; Cell Line; In Vitro Techniques; Liver; Male; Membrane Transport Proteins; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Perfusion; Phenobarbital; Rats; Rats, Wistar; Transfection; Transport Vesicles | 2002 |
UDP-glucuronosyltransferase activities in human liver microsomes and in some laboratory animal species.
Topics: Adolescent; Aged; Animals; Camphanes; Chloramphenicol; Eugenol; Female; Glucuronides; Glucuronosyltransferase; Humans; Male; Mice; Mice, Inbred C57BL; Microsomes, Liver; Middle Aged; Nitrophenols; Phenobarbital; Rats; Rats, Sprague-Dawley; Rats, Wistar; Species Specificity; Swine; Uridine Diphosphate | 1981 |
Sample stacking microemulsion electrokinetic capillary chromatography induced by reverse migrating pseudostationary phase for the quantification of phenobarbital and its p-hydroxyphenobarbital metabolite in rat urine.
Topics: Animals; Buffers; Chromatography, Micellar Electrokinetic Capillary; Emulsions; Hydrogen-Ion Concentration; Limit of Detection; Linear Models; Motion; Oils; Phenobarbital; Rats; Reproducibility of Results; Sodium Dodecyl Sulfate; Solid Phase Extraction; Surface-Active Agents; Urinalysis; Water | 2011 |