phenethyl isothiocyanate has been researched along with benzyl isothiocyanate in 66 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.52) | 18.7374 |
| 1990's | 15 (22.73) | 18.2507 |
| 2000's | 21 (31.82) | 29.6817 |
| 2010's | 27 (40.91) | 24.3611 |
| 2020's | 2 (3.03) | 2.80 |
| Authors | Studies |
|---|---|
| Kamath, A; Morris, ME; Tseng, E | 1 |
| Hu, K; Morris, ME | 1 |
| Dansette, PM; Fontana, E; Poli, SM | 1 |
| Amin, S; Desai, D; Huh, SJ; Madhunapantula, SV; Robertson, GP; Sharma, A; Sharma, AK | 1 |
| Amin, S; Desai, D; Emmert, SW; Richie, JP | 1 |
| Baraldi, PG; Geppetti, P; Materazzi, S; Preti, D | 1 |
| Chung, FL; Di Pasqua, AJ; Fine, RL; Govind, S; Hong, C; Mao, Y; McCracken, E; Mi, L; Tomita, Y; Wang, X; Woodrick, JC; Wu, JY | 1 |
| Güneş, U; Kurt, S; Soylu, EM | 1 |
| Błażewska, K; Gajda, A; Gajda, T; Oleksyszyn, J; Psurski, M; Wietrzyk, J | 1 |
| Dale, EJ; Gamble, AB; Gommans, AL; Hampton, MB; Nakatani, Y; Rutledge, MT; Smith, RA; Spencer, ES; Tyndall, JD; Vo, CT; Wilbanks, SM | 1 |
| Masuda, H; Terada, Y; Watanabe, T | 1 |
| Gajda, T; Grzywa, R; Oleksyszyn, J; Psurski, M; Rudnicka, A; Wietrzyk, J; Winiarski, Ł | 1 |
| Baggio, R; El Oualid, F; Fasci, D; Hedstrom, L; Lawson, AP; Long, MJC; Qian, Y; Rozhansky, L; Weerapana, E | 1 |
| Amin, SG; Chung, FL; Hecht, SS; Morse, MA; Reinhardt, JC; Stoner, GD | 1 |
| Chung, FL; Hecht, SS; Morse, MA | 1 |
| Amin, SG; Chung, FL; Hecht, SS; Morse, MA | 1 |
| Johnson, IT; Musk, SR | 1 |
| Kresty, LA; Morse, MA; Stoner, GD; Wilkinson, JT | 1 |
| Crease, DJ; Ketterer, B; Meyer, DJ | 1 |
| Hecht, SS; Isaacs, S; Trushin, N | 1 |
| Hamilton, SM; Teel, RW; Zhang, Z | 1 |
| Amin, S; Hecht, SS; Lin, JM; Trushin, N | 1 |
| Chung, FL; Eklind, KI; Guo, Z; Smith, TJ; Wang, E; Yang, CS | 1 |
| Fyfe, D; Johnson, IT; Musk, SR; Smith, TK; Stening, P; Stephenson, P | 1 |
| Chung, FL; Conaway, CC; Jiao, D; Koehl, W; Wang, MH; Yang, CS | 1 |
| Hecht, SS | 1 |
| Harvey, KJ; Kong, AN; Mandlekar, S; Ucker, DS; Yu, R | 1 |
| Futakuchi, M; Hirose, M; Kimoto, N; Ogawa, K; Sano, M; Shirai, T; Yamaguchi, T | 1 |
| Carlton, PS; Kresty, LA; Morse, MA; Siglin, JC; Stoner, GD | 1 |
| Hecht, SS; Kenney, PM; Trushin, N; Upadhyaya, P; Wang, M | 1 |
| Morimitsu, Y; Murakami, A; Naito, Y; Nakagawa, Y; Nakamura, Y; Ohigashi, H; Osawa, T; Uchida, K; Uzu, T | 1 |
| Hecht, SS; Kenney, PM; Liang, H; Staretz, ME; Sticha, KR; Wang, M | 1 |
| Brand, L; Goosen, TC; Hollenberg, PF; Kent, UM | 1 |
| Chung, FL; Goosen, T; Hollenberg, PF; Kent, UM; Moreno, RL | 1 |
| Amin, S; Chiao, JW; Chung, FL; Conaway, CC; Dai, W; Reinhardt, J; Wang, CX; Whysner, J; Yang, YM | 1 |
| Boysen, G; Hecht, SS; Kenney, PM; Liang, H; Sticha, KR; Su, X; Upadhyaya, P; Wang, M | 1 |
| Gminski, R; Kansmüller, S; Kassie, F; Laky, B; Lhoste, E; Mersch-Sundermann, V; Scharf, G | 1 |
| Boysen, G; Hecht, SS; Kenney, PM; Upadhyaya, P; Wang, M | 1 |
| Duthie, SJ; Padfield, PJ; Pirie, L; Thompson, DG; Visanji, JM | 1 |
| Li, J; Yao, S; Zhang, Y | 1 |
| Chun, JA; Hollenberg, PF; von Weymarn, LB | 1 |
| Li, G; Song, L; Tang, L; Zhang, Y | 1 |
| Chung, FL; Mi, L | 1 |
| Ding, L; Kang, L; Wang, ZY | 1 |
| Chung, FL; Gan, N; Mi, L | 1 |
| Kim, MG; Lee, HS | 1 |
| Kumar, A; Sabbioni, G | 1 |
| Kato, Y; Kitamoto, N; Nakamura, T; Osawa, T | 1 |
| Li, Y; Liu, B; Wu, X; Xu, K; Yan, H; Zhou, Q; Zhu, Y | 1 |
| Han, W; Shi, M; Spivack, SD; Tan, XL; Tang, H | 1 |
| Chou, ST; Chung, JG; Hsia, TC; Huang, AC; Ko, YC; Liao, CL; Lu, HF; Ma, CY; Wu, CL; Yang, JS | 1 |
| Li, Y; Liu, B; Wu, H; Wu, X; Xu, K; Yan, H; Zhou, Q; Zhu, Y | 1 |
| Chen, YT; Guan, Z; Hsieh, TS; Kerrigan, J; Lin, RK; Liu, LF; Lu, CH; Lyu, YL; Tsai, YC; Zhou, N | 1 |
| Chung, FL; Mi, L; Veenstra, TD; Xiao, Z | 1 |
| Fukutomi, R; Miyoshi, N; Nakamura, Y; Ohshima, H; Tomono, S; Yonemochi, T | 1 |
| Amjad, AI; Chinni, SR; Parikh, R; Sakao, K; Singh, SV; Vyas, AR | 1 |
| Bae, YS; Chang, HW; Chang, YC; Cho, HJ; Chung, IK; Jeong, YJ; Jin, F; Kim, CH; Kim, M; Lee, CS; Park, KK; Park, YY; Shin, JM | 1 |
| Coffey, RT; El Oualid, F; Hedstrom, L; Lawson, AP; Long, MJC; Qian, Y; Weerapana, E | 1 |
| Bui, LC; Cariou, K; Dodd, RH; Dupret, JM; Duval, R; Mathieu, C; Petit, E; Rodrigues-Lima, F; Xu, X | 1 |
| Blessing, B; Günther, F; Kaiser, SJ; Mutters, NT | 1 |
| Chiang, TA; Chung, JG; Hsiao, YT; Huang, YP; Lai, KC; Ma, YS; Yang, JL | 1 |
| Chung, JG; Hsiao, YT; Liao, CL; Lin, CC; Lin, JJ; Ma, YS | 1 |
| Heikkila, JJ; Khamis, I | 1 |
| Chen, HW; Chuang, WT; Huang, CS; Lii, CK; Liu, YT; Lo, CW; Yao, HT | 1 |
| Calado, AM; Pereira, C; Sampaio, AC | 1 |
| Anestopoulos, I; Franco, R; Kyriakou, S; Mitsiogianni, M; Panayiotidis, MI; Pappa, A; Trafalis, DT | 1 |
3 review(s) available for phenethyl isothiocyanate and benzyl isothiocyanate
| Article | Year |
|---|---|
Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.
Topics: Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; Isoenzymes; Structure-Activity Relationship; Terminology as Topic | 2005 |
Transient receptor potential ankyrin 1 (TRPA1) channel as emerging target for novel analgesics and anti-inflammatory agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Asthma; Humans; Ion Channel Gating; Neurons; Pain; Peripheral Nervous System Diseases; Pulmonary Disease, Chronic Obstructive; Transient Receptor Potential Channels | 2010 |
Chemoprevention of lung cancer by isothiocyanates.
Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Carcinogens; Isothiocyanates; Lung Neoplasms; Nitrosamines | 1996 |
63 other study(ies) available for phenethyl isothiocyanate and benzyl isothiocyanate
| Article | Year |
|---|---|
Effect of organic isothiocyanates on the P-glycoprotein- and MRP1-mediated transport of daunomycin and vinblastine.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Daunorubicin; Humans; Isothiocyanates; Tumor Cells, Cultured; Vinblastine | 2002 |
Effects of benzyl-, phenethyl-, and alpha-naphthyl isothiocyanates on P-glycoprotein- and MRP1-mediated transport.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Humans; Isothiocyanates; Multidrug Resistance-Associated Proteins | 2004 |
Synthesis and anticancer activity comparison of phenylalkyl isoselenocyanates with corresponding naturally occurring and synthetic isothiocyanates.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Chemistry, Pharmaceutical; Drug Design; Drug Screening Assays, Antitumor; Humans; Inhibitory Concentration 50; Isothiocyanates; Mice; Models, Chemical; Neoplasm Transplantation; Structure-Activity Relationship | 2008 |
Enhanced Nrf2-dependent induction of glutathione in mouse embryonic fibroblasts by isoselenocyanate analog of sulforaphane.
Topics: Animals; Cell Line, Tumor; Cyanates; Embryo, Mammalian; Fibroblasts; Glutathione; Humans; Isothiocyanates; Mice; NF-E2-Related Factor 2; Sulfoxides; Thiocyanates | 2010 |
Selective depletion of mutant p53 by cancer chemopreventive isothiocyanates and their structure-activity relationships.
Topics: Anticarcinogenic Agents; Apoptosis; Cell Line, Tumor; Cysteine; Drug Screening Assays, Antitumor; Humans; Isothiocyanates; Mutation; Protein Conformation; Structure-Activity Relationship; Tumor Suppressor Protein p53 | 2011 |
In vitro and in vivo antifungal activity of synthetic pure isothiocyanates against Sclerotinia sclerotiorum.
Topics: Ascomycota; Brassicaceae; Fungicides, Industrial; Isothiocyanates; Plant Extracts | 2011 |
Synthesis and antiproliferative activity of novel α- and β-dialkoxyphosphoryl isothiocyanates.
Topics: Antineoplastic Agents; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Isothiocyanates; Structure-Activity Relationship | 2011 |
Multiple binding modes of isothiocyanates that inhibit macrophage migration inhibitory factor.
Topics: Drug Design; Enzyme Inhibitors; Humans; Intramolecular Oxidoreductases; Isothiocyanates; Jurkat Cells; Macrophage Migration-Inhibitory Factors; Molecular Docking Simulation; Protein Binding; Protein Conformation | 2015 |
Structure-Activity Relationship Study on Isothiocyanates: Comparison of TRPA1-Activating Ability between Allyl Isothiocyanate and Specific Flavor Components of Wasabi, Horseradish, and White Mustard.
Topics: Animals; Armoracia; Humans; Isothiocyanates; Mice; Molecular Structure; Mustard Plant; Structure-Activity Relationship; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPV Cation Channels | 2015 |
Synthesis and biological activity of diisothiocyanate-derived mercapturic acids.
Topics: Acetylcysteine; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Colon; Colonic Neoplasms; Humans; Isothiocyanates | 2016 |
Diarylcarbonates are a new class of deubiquitinating enzyme inhibitor.
Topics: Carbonates; Deubiquitinating Enzymes; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Molecular Structure; Structure-Activity Relationship; Ubiquitination | 2019 |
Effect of dietary aromatic isothiocyanates fed subsequent to the administration of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone on lung tumorigenicity in mice.
Topics: Animals; Body Weight; Carcinogens; Female; Isothiocyanates; Lung Neoplasms; Mice; Nitrosamines; Thiocyanates | 1990 |
Inhibition of tobacco-specific nitrosamine 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumors and DNA methylation in F344 rats and A/J mice by phenethyl isothiocyanate.
Topics: Animals; DNA; Isothiocyanates; Liver Neoplasms, Experimental; Lung Neoplasms; Methylation; Mice; Mice, Inbred A; Nitrosamines; Nose Neoplasms; Organ Specificity; Rats; Rats, Inbred F344; Thiocyanates | 1990 |
Effects of aromatic isothiocyanates on tumorigenicity, O6-methylguanine formation, and metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mouse lung.
Topics: Adenoma; Animals; Cricetinae; Cyanates; Female; Guanine; Isocyanates; Isothiocyanates; Lung; Lung Neoplasms; Mice; Microsomes; Nitrosamines; Thiocyanates | 1989 |
The clastogenic effects of isothiocyanates.
Topics: Animals; Cell Line; Chromosome Aberrations; Deer; Isothiocyanates; Mutagens; Thiocyanates | 1993 |
Effect of alkyl chain length on inhibition of N-nitrosomethylbenzylamine-induced esophageal tumorigenesis and DNA methylation by isothiocyanates.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Dimethylnitrosamine; DNA; Dose-Response Relationship, Drug; Esophageal Neoplasms; Isothiocyanates; Male; Methylation; Molecular Structure; Rats; Rats, Inbred F344; Structure-Activity Relationship | 1995 |
Forward and reverse catalysis and product sequestration by human glutathione S-transferases in the reaction of GSH with dietary aralkyl isothiocyanates.
Topics: Anticarcinogenic Agents; Catalysis; Diet; Glutathione; Glutathione Transferase; Humans; Hydrogen-Ion Concentration; Isothiocyanates; Kinetics | 1995 |
Lung tumor induction in A/J mice by the tobacco smoke carcinogens 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and benzo[a]pyrene: a potentially useful model for evaluation of chemopreventive agents.
Topics: Adenoma; Administration, Oral; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Dose-Response Relationship, Drug; Female; Injections, Intraperitoneal; Isothiocyanates; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Stomach Neoplasms | 1994 |
Effects of isothiocyanate alkyl chain-length on hamster liver cytochrome P-450 activity.
Topics: Animals; Cricetinae; Cytochrome P-450 Enzyme System; Isothiocyanates; Male; Mesocricetus; Mice; Microsomes, Liver; Mutagenicity Tests; Mutation; Nitrosamines; Oxidation-Reduction; Rats; Rats, Inbred F344; Testosterone; Thiocyanates | 1994 |
Effects of isothiocyanates on tumorigenesis by benzo[a]pyrene in murine tumor models.
Topics: Animals; Benzo(a)pyrene; Drug Screening Assays, Antitumor; Female; Isothiocyanates; Lung Neoplasms; Mice; Nitrosamines; Pyridines; Skin Neoplasms; Stomach Neoplasms | 1993 |
Structure-activity relationships of arylalkyl isothiocyanates for the inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolism and the modulation of xenobiotic-metabolizing enzymes in rats and mice.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Female; Isothiocyanates; Male; Mice; Microsomes; Microsomes, Liver; Nitrosamines; Oxidation-Reduction; Rats; Rats, Inbred F344; Structure-Activity Relationship; Thiocyanates | 1993 |
Selective toxicity of compounds naturally present in food toward the transformed phenotype of human colorectal cell line HT29.
Topics: Adenocarcinoma; Allyl Compounds; Anticarcinogenic Agents; Butyrates; Butyric Acid; Cell Differentiation; Cell Division; Cell Line, Transformed; Colorectal Neoplasms; Dimethylformamide; Food; Humans; Isothiocyanates; Phenotype; Sulfides; Tumor Cells, Cultured | 1995 |
Inhibition of N-nitrosodimethylamine demethylase in rat and human liver microsomes by isothiocyanates and their glutathione, L-cysteine, and N-acetyl-L-cysteine conjugates.
Topics: Acetylcysteine; Animals; Cysteine; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Dose-Response Relationship, Drug; Glutathione; Humans; In Vitro Techniques; Isothiocyanates; Kinetics; Male; Microsomes, Liver; Rats; Rats, Inbred F344 | 1996 |
Chemopreventive isothiocyanates induce apoptosis and caspase-3-like protease activity.
Topics: Anticarcinogenic Agents; Apoptosis; Caspase 3; Caspases; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Induction; HeLa Cells; Humans; Isothiocyanates; Neoplasm Proteins; Oligopeptides; Poly(ADP-ribose) Polymerases; Thiocyanates | 1998 |
Strong promoting activity of phenylethyl isothiocyanate and benzyl isothiocyanate on urinary bladder carcinogenesis in F344 male rats.
Topics: Animals; Butylhydroxybutylnitrosamine; Carcinogens; Diet; Diethylnitrosamine; Drug Synergism; Hyperplasia; Isothiocyanates; Liver; Male; Rats; Rats, Inbred F344; Urinary Bladder; Urinary Bladder Neoplasms | 1998 |
Isothiocyanates and freeze-dried strawberries as inhibitors of esophageal cancer.
Topics: Animals; Dimethylnitrosamine; Ellagic Acid; Esophageal Neoplasms; Freeze Drying; Fruit; Guanosine; Humans; Isothiocyanates; Male; Rats; Rats, Inbred F344 | 1999 |
Effects of phenethyl isothiocyanate and benzyl isothiocyanate, individually and in combination, on lung tumorigenesis induced in A/J mice by benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
Topics: Analysis of Variance; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Body Weight; Carcinogens; Diet; Dose-Response Relationship, Drug; Drug Therapy, Combination; Isothiocyanates; Lung Neoplasms; Mice; Mice, Inbred Strains; Nitrosamines | 2000 |
A glutathione S-transferase inducer from papaya: rapid screening, identification and structure-activity relationship of isothiocyanates.
Topics: Animals; Blotting, Western; Cells, Cultured; Enzyme Induction; Epithelial Cells; Fluorescence; Fruit; Glutathione Transferase; Isothiocyanates; Lauraceae; Liver; Rats; Reactive Oxygen Species; Structure-Activity Relationship | 2000 |
Effects of benzyl isothiocyanate and phenethyl isothiocyanate on benzo[a]pyrene metabolism and DNA adduct formation in the A/J mouse.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Biotransformation; Carcinogens; DNA Adducts; Dose-Response Relationship, Drug; Drug Interactions; Female; Fluorometry; Inhibitory Concentration 50; Isothiocyanates; Lung; Lung Neoplasms; Mice; Mice, Inbred A; Microsomes, Liver | 2000 |
Inactivation of cytochrome P450 2B1 by benzyl isothiocyanate, a chemopreventative agent from cruciferous vegetables.
Topics: Animals; Anticarcinogenic Agents; Brassica; Chemoprevention; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2B1; Dose-Response Relationship, Drug; Enzyme Inhibitors; In Vitro Techniques; Isothiocyanates; Male; Microsomes, Liver; Rats; Rats, Long-Evans | 2000 |
Differential effects of naturally occurring isothiocyanates on the activities of cytochrome P450 2E1 and the mutant P450 2E1 T303A.
Topics: Animals; Binding Sites; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Isothiocyanates; Mutation; Rabbits; Radiopharmaceuticals; Spectrometry, Mass, Electrospray Ionization | 2001 |
Inhibition of benzo(a)pyrene-induced lung tumorigenesis in A/J mice by dietary N-acetylcysteine conjugates of benzyl and phenethyl isothiocyanates during the postinitiation phase is associated with activation of mitogen-activated protein kinases and p53 a
Topics: Acetylcysteine; Animals; Anticarcinogenic Agents; Apoptosis; bcl-2-Associated X Protein; Benzo(a)pyrene; Carcinogens; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Enzyme Activation; Female; Gene Expression Regulation, Neoplastic; Isothiocyanates; Lung; Lung Neoplasms; Mice; Mice, Inbred A; Mitogen-Activated Protein Kinases; NF-kappa B; Phosphorylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Transcription Factor AP-1; Tumor Suppressor Protein p53 | 2002 |
Effects of benzyl isothiocyanate and phenethyl isothiocyanate on DNA adduct formation by a mixture of benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mouse lung.
Topics: Animals; Benzo(a)pyrene; Carcinogens; DNA; DNA Adducts; Drug Interactions; Female; Isothiocyanates; Lung; Mice; Mice, Inbred A; Nitrosamines | 2002 |
Effects of garden and water cress juices and their constituents, benzyl and phenethyl isothiocyanates, towards benzo(a)pyrene-induced DNA damage: a model study with the single cell gel electrophoresis/Hep G2 assay.
Topics: Benzo(a)pyrene; Brassicaceae; Cell Line; DNA Damage; Humans; Isothiocyanates; Lepidium sativum; Plant Extracts; Vegetables | 2003 |
Effects of benzyl isothiocyanate and 2-phenethyl isothiocyanate on benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolism in F-344 rats.
Topics: Animals; Benzo(a)pyrene; Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Hemoglobins; Isothiocyanates; Male; Nitrosamines; Rats; Rats, Inbred F344 | 2003 |
Dietary isothiocyanates inhibit Caco-2 cell proliferation and induce G2/M phase cell cycle arrest, DNA damage, and G2/M checkpoint activation.
Topics: Brassica; Caco-2 Cells; Cell Division; Checkpoint Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Diet; DNA Damage; Flow Cytometry; G2 Phase; Humans; Isothiocyanates; Phosphorylation; Protein Serine-Threonine Kinases | 2004 |
The role of c-Jun in the AP-1 activation induced by naturally occurring isothiocyanates.
Topics: Anticarcinogenic Agents; Biotransformation; Blotting, Western; Carcinogens; Cell Line, Tumor; DNA, Neoplasm; Electrophoretic Mobility Shift Assay; Gene Expression Regulation, Neoplastic; Genes, fos; Genes, jun; Humans; Isothiocyanates; Luciferases; Phosphorylation; Transcription Factor AP-1; Urinary Bladder Neoplasms | 2005 |
Effects of benzyl and phenethyl isothiocyanate on P450s 2A6 and 2A13: potential for chemoprevention in smokers.
Topics: Anticarcinogenic Agents; Aryl Hydrocarbon Hydroxylases; Chemoprevention; Cytochrome P-450 CYP2A6; Humans; Isothiocyanates; Lung Neoplasms; Mixed Function Oxygenases; Smoking | 2006 |
The principal urinary metabolites of dietary isothiocyanates, N-acetylcysteine conjugates, elicit the same anti-proliferative response as their parent compounds in human bladder cancer cells.
Topics: Acetylcysteine; Apoptosis; Cell Cycle; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Isothiocyanates; Sulfoxides; Thiocyanates; Urinary Bladder Neoplasms | 2006 |
Binding to protein by isothiocyanates: a potential mechanism for apoptosis induction in human non small lung cancer cells.
Topics: Apoptosis; Carcinoma, Non-Small-Cell Lung; Cysteine; DNA Damage; Humans; Isothiocyanates; Lung Neoplasms; Oxidative Stress; Protein Binding; Protein Carbonylation; Sulfoxides; Thiocyanates; Tubulin | 2008 |
Isothiocyanates repress estrogen receptor alpha expression in breast cancer cells.
Topics: Antineoplastic Agents; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Estrogen Receptor alpha; Female; Humans; Isothiocyanates; Reverse Transcriptase Polymerase Chain Reaction; Transfection | 2009 |
Aggresome-like structure induced by isothiocyanates is novel proteasome-dependent degradation machinery.
Topics: Anticarcinogenic Agents; Biomarkers; Cytoplasm; HeLa Cells; Humans; Isothiocyanates; Proteasome Endopeptidase Complex; Protein Folding; Sulfoxides; Thiocyanates; Tubulin | 2009 |
Growth-inhibiting activities of phenethyl isothiocyanate and its derivatives against intestinal bacteria.
Topics: Anti-Bacterial Agents; Bifidobacterium; Chemical Fractionation; Clostridium; Disk Diffusion Antimicrobial Tests; Escherichia coli; Gastroenteritis; Humans; Intestines; Isothiocyanates; Lactobacillus; Oils, Volatile; Seeds; Sinapis; Species Specificity; Structure-Activity Relationship | 2009 |
New biomarkers for monitoring the levels of isothiocyanates in humans.
Topics: Animals; Biomarkers; Chromatography, High Pressure Liquid; Hemoglobins; Humans; Isothiocyanates; Kinetics; Lysine; Mice; Rats; Serum Albumin; Spectrometry, Mass, Electrospray Ionization; Sulfoxides; Thiocyanates | 2010 |
Immunochemical detection of food-derived isothiocyanate as a lysine conjugate.
Topics: Allyl Compounds; Animals; Antibodies, Monoclonal; Carica; Cattle; Enzyme-Linked Immunosorbent Assay; Food Analysis; Isocyanates; Isothiocyanates; Lysine; Serum Albumin, Bovine; Wasabia | 2010 |
Isothiocyanates induce oxidative stress and suppress the metastasis potential of human non-small cell lung cancer cells.
Topics: Acetylcysteine; Antineoplastic Agents, Phytogenic; Antioxidants; beta Catenin; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Flow Cytometry; Glutathione; Humans; Inhibitory Concentration 50; Isothiocyanates; Lung Neoplasms; Matrix Metalloproteinase 2; Neoplasm Invasiveness; NF-kappa B; Nuclear Proteins; Oxidative Stress; Proto-Oncogene Proteins c-akt; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Transfection; Twist-Related Protein 1 | 2010 |
Candidate dietary phytochemicals modulate expression of phase II enzymes GSTP1 and NQO1 in human lung cells.
Topics: Anticarcinogenic Agents; Brassica; Bronchi; Camellia sinensis; Catechin; Cell Division; Cell Line; Cell Line, Tumor; Epithelial Cells; Gene Expression; Glutathione S-Transferase pi; Humans; Isothiocyanates; Lung; Lung Neoplasms; NAD(P)H Dehydrogenase (Quinone); Plant Extracts; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfoxides; Thiocyanates | 2010 |
Benzyl isothiocyanate (BITC) and phenethyl isothiocyanate (PEITC)-mediated generation of reactive oxygen species causes cell cycle arrest and induces apoptosis via activation of caspase-3, mitochondria dysfunction and nitric oxide (NO) in human osteogenic
Topics: Anticarcinogenic Agents; Apoptosis; Bone Neoplasms; Caspase 3; Cell Cycle; Cell Line, Tumor; DNA Damage; Drug Evaluation, Preclinical; Enzyme Activation; Humans; Isothiocyanates; Membrane Potential, Mitochondrial; Nitric Oxide; Osteosarcoma; Reactive Oxygen Species; Signal Transduction | 2011 |
Mitogen-activated protein kinase mediates the apoptosis of highly metastatic human non-small cell lung cancer cells induced by isothiocyanates.
Topics: Acetylcysteine; Antioxidants; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Cycle Checkpoints; Cell Line, Tumor; Cyclin B1; Gene Expression; Humans; Isothiocyanates; Lung Neoplasms; MAP Kinase Signaling System; Neoplasm Metastasis; Transcription Factor AP-1 | 2011 |
Dietary isothiocyanate-induced apoptosis via thiol modification of DNA topoisomerase IIα.
Topics: Animals; Antigens, Neoplasm; Apoptosis; Cell Line, Transformed; Cell Line, Tumor; Cell Proliferation; Cysteine; Diet; DNA Damage; DNA Fragmentation; DNA Topoisomerases, Type II; DNA-Binding Proteins; Fibroblasts; Gene Knockdown Techniques; Gene Silencing; Histones; Humans; Isothiocyanates; Mice; Nucleosomes; Poly-ADP-Ribose Binding Proteins; ras Proteins; RNA, Small Interfering; Signal Transduction; Sulfhydryl Compounds | 2011 |
Proteomic analysis of covalent modifications of tubulins by isothiocyanates.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cysteine; Diet; Electrophoresis, Gel, Two-Dimensional; Humans; Isothiocyanates; Lung Neoplasms; Mass Spectrometry; Microtubules; Mitosis; Phytotherapy; Plant Extracts; Protein Binding; Protein Isoforms; Proteomics; Tubulin | 2012 |
Development and application of a method for identification of isothiocyanate-targeted molecules in colon cancer cells.
Topics: Animals; Cattle; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Colonic Neoplasms; HCT116 Cells; Humans; Insulin; Isothiocyanates; Peptides; Principal Component Analysis; Spectrometry, Mass, Electrospray Ionization | 2012 |
CXCR4 is a novel target of cancer chemopreventative isothiocyanates in prostate cancer cells.
Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Cell Line, Tumor; Chemoprevention; Humans; Isothiocyanates; Male; Mice; Mice, Transgenic; Molecular Targeted Therapy; Prostatic Neoplasms; Receptors, CXCR4; RNA, Small Interfering; Sulfoxides; Xenograft Model Antitumor Assays | 2015 |
Isothiocyanates inhibit the invasion and migration of C6 glioma cells by blocking FAK/JNK-mediated MMP-9 expression.
Topics: Cell Line, Tumor; Cell Movement; Extracellular Matrix; Focal Adhesion Kinase 1; Gene Expression Regulation, Neoplastic; Glioma; Humans; Isothiocyanates; MAP Kinase Kinase 4; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Neoplasm Metastasis; NF-kappa B; Sulfoxides; Transcription Factor AP-1 | 2015 |
Naturally Occurring Isothiocyanates Exert Anticancer Effects by Inhibiting Deubiquitinating Enzymes.
Topics: Animals; Chlorocebus aethiops; COS Cells; Endopeptidases; HeLa Cells; Humans; Isothiocyanates; K562 Cells; MCF-7 Cells; Melanoma, Experimental; Mice; NIH 3T3 Cells; Ubiquitin; Ubiquitin Thiolesterase; Ubiquitin-Protein Ligase Complexes; Ubiquitination | 2015 |
Identification of cancer chemopreventive isothiocyanates as direct inhibitors of the arylamine N-acetyltransferase-dependent acetylation and bioactivation of aromatic amine carcinogens.
Topics: Acetylation; Amines; Arylamine N-Acetyltransferase; Breast Neoplasms; Carcinogens; DNA Adducts; Enzyme Inhibitors; Female; Humans; Isothiocyanates; Kinetics; Tumor Cells, Cultured | 2016 |
Natural isothiocyanates express antimicrobial activity against developing and mature biofilms of Pseudomonas aeruginosa.
Topics: Anti-Bacterial Agents; Biofilms; Drug Synergism; Isothiocyanates; Microbial Sensitivity Tests; Pseudomonas aeruginosa | 2017 |
Benzyl isothiocyanate and phenethyl isothiocyanate inhibit murine melanoma B16F10 cell migration and invasion in vitro.
Topics: Animals; Cell Line, Tumor; Cell Movement; Cell Proliferation; Gene Expression Regulation, Neoplastic; Humans; Isothiocyanates; Matrix Metalloproteinase 2; Melanoma, Experimental; Mice; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; Signal Transduction | 2017 |
Phenethyl Isothiocyanate (PEITC) and Benzyl Isothiocyanate (BITC) Inhibit Human Melanoma A375.S2 Cell Migration and Invasion by Affecting MAPK Signaling Pathway
Topics: Anticarcinogenic Agents; Apoptosis; Cell Movement; Cell Proliferation; Gene Expression Regulation, Neoplastic; Humans; In Vitro Techniques; Isothiocyanates; MAP Kinase Signaling System; Melanoma; Neoplasm Invasiveness; NF-kappa B; Signal Transduction; Tumor Cells, Cultured | 2017 |
Effect of isothiocyanates, BITC and PEITC, on stress protein accumulation, protein aggregation and aggresome-like structure formation in Xenopus A6 kidney epithelial cells.
Topics: Animals; Epithelial Cells; Gene Expression Regulation; Heme Oxygenase-1; HSP30 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Isothiocyanates; Kidney; Xenopus | 2018 |
Benzyl Isothiocyanate and Phenethyl Isothiocyanate Inhibit Adipogenesis and Hepatosteatosis in Mice with Obesity Induced by a High-Fat Diet.
Topics: Adipogenesis; Animals; Diet, High-Fat; Fatty Liver; Humans; Isothiocyanates; Male; Mice; Mice, Inbred C57BL; Obesity | 2019 |
The effect of benzyl isothiocyanate on Candida albicans growth, cell size, morphogenesis, and ultrastructure.
Topics: Antifungal Agents; Candida albicans; Cell Wall; Disk Diffusion Antimicrobial Tests; Isothiocyanates; Microbial Viability; Oxidative Stress | 2020 |
Benzyl and phenethyl isothiocyanates as promising epigenetic drug compounds by modulating histone acetylation and methylation marks in malignant melanoma.
Topics: Acetylation; Cell Line, Tumor; Cell Survival; Epigenesis, Genetic; Histones; Humans; Isothiocyanates; Melanoma; Methylation; Skin Neoplasms | 2021 |