phenelzine and selegiline

phenelzine has been researched along with selegiline in 34 studies

Research

Studies (34)

TimeframeStudies, this research(%)All Research%
pre-199013 (38.24)18.7374
1990's4 (11.76)18.2507
2000's9 (26.47)29.6817
2010's7 (20.59)24.3611
2020's1 (2.94)2.80

Authors

AuthorsStudies
Baker, GB; Coutts, RT; Ling, L; Pang, PK; Shan, JJ; Sloley, BD; Urichuk, LJ1
Dansette, PM; Fontana, E; Poli, SM1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY1
Byun, Y; Han, MH; Hong, SH; Jung, HI; Noh, M; Park, J; Park, S1
Almos, T; Edmondson, DE; Massari, ME; Rojas, RJ; Scott, R1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Agosti, V; Quitkin, FM; Stewart, JW1
Banerjee, DK; Kelner, K; Offutt, L; Pollard, HB; Youdim, MB1
Egashira, T; Obata, T; Yamanaka, Y1
Fagervall, I; Ross, SB1
Blier, P; de Montigny, C1
Blau, M; Carmel, A; Delmon, L; Holman, BL; Johnson, D; Moingeon, P; Moretti, JL1
Linet, LS1
Boor, PJ; Hysmith, RM2
Cesura, AM; Da Prada, M; Kettler, R; Richards, JG1
de Montigny, C; Descarries, L; Ferron, A; Reader, TA1
Möhrke, W; Mutschler, E1
Davies, SO; Harrison, W; Liebowitz, MR; Markowitz, J; McGrath, PJ; Quitkin, FM; Rabkin, JG; Stewart, JW1
Asnis, GM; Endicott, J; Halbreich, U; Nathan, RS; Novacenko, H; Ostrow, L; Sachar, EJ1
Boulton, AA; Davis, BA; Fang, J; Yu, PH1
Baker, GB; Greenshaw, AJ; Paetsch, PR1
Baker, GB; Todd, KG1
Archer, T; Fredriksson, A; Palomo, T1
Gorman, JM1
Masand, PS; Pae, CU; Patkar, AA1
Baker, GB; Sowa, B; Todd, KG1
Blier, P; Chenu, F; El Mansari, M1
Goldberg, JF; Thase, ME1
Bhyrapuneni, G; Manoharan, A; Mohammed, AR; Nirogi, R; Palacharla, RC; Ponnamaneni, RK1
Estévez, RF; Gillman, PK; Hoffman, GR; Olson, MG; Schoffstall, AM; Stabio, ME; Van den Eynde, V1

Reviews

6 review(s) available for phenelzine and selegiline

ArticleYear
Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.
    Current drug metabolism, 2005, Volume: 6, Issue:5

    Topics: Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; Isoenzymes; Structure-Activity Relationship; Terminology as Topic

2005
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
[Interactions between monoaminergic neurons projecting to the cerebral cortex].
    L'union medicale du Canada, 1985, Volume: 114, Issue:12

    Topics: Animals; Cerebral Cortex; Clorgyline; Monoamine Oxidase Inhibitors; Phenelzine; Rats; Receptors, Adrenergic; Receptors, Serotonin; Selegiline

1985
Kinetics of MAO inhibitors.
    Modern problems of pharmacopsychiatry, 1983, Volume: 19

    Topics: Animals; Humans; Hydrogen-Ion Concentration; Kinetics; Monoamine Oxidase Inhibitors; Phenelzine; Selegiline; Tranylcypromine

1983
Transdermal selegiline: the new generation of monoamine oxidase inhibitors.
    CNS spectrums, 2006, Volume: 11, Issue:5

    Topics: Administration, Cutaneous; Depressive Disorder, Major; Drug Interactions; Humans; Monoamine Oxidase Inhibitors; Phenelzine; Selegiline; Tranylcypromine

2006
Classics in Chemical Neuroscience: Selegiline, Isocarboxazid, Phenelzine, and Tranylcypromine.
    ACS chemical neuroscience, 2023, 12-06, Volume: 14, Issue:23

    Topics: Antidepressive Agents; Isocarboxazid; Monoamine Oxidase Inhibitors; Phenelzine; Selegiline; Tranylcypromine

2023

Trials

2 trial(s) available for phenelzine and selegiline

ArticleYear
Life satisfaction and psychosocial functioning in chronic depression: effect of acute treatment with antidepressants.
    Journal of affective disorders, 1991, Volume: 23, Issue:1

    Topics: Activities of Daily Living; Adult; Antidepressive Agents; Chronic Disease; Depressive Disorder; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Imipramine; Male; Personal Satisfaction; Personality Tests; Phenelzine; Selegiline; Single-Blind Method; Social Adjustment

1991
l-Deprenyl in atypical depressives.
    Archives of general psychiatry, 1984, Volume: 41, Issue:8

    Topics: Adult; Clinical Trials as Topic; Depressive Disorder; Dextroamphetamine; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Emotions; Female; Humans; Male; Phenelzine; Phenethylamines; Placebos; Psychiatric Status Rating Scales; Selegiline

1984

Other Studies

26 other study(ies) available for phenelzine and selegiline

ArticleYear
Synthesis of N-propargylphenelzine and analogues as neuroprotective agents.
    Bioorganic & medicinal chemistry letters, 2001, Oct-22, Volume: 11, Issue:20

    Topics: Animals; Hippocampus; Mice; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Norepinephrine; Phenelzine

2001
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
    Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21

    Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship

2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
    Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

    Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding

2012
The opposite effect of isotype-selective monoamine oxidase inhibitors on adipogenesis in human bone marrow mesenchymal stem cells.
    Bioorganic & medicinal chemistry letters, 2013, Jun-01, Volume: 23, Issue:11

    Topics: 3T3-L1 Cells; Adipogenesis; Animals; Antidiuretic Agents; Bone Marrow Cells; Humans; Mesenchymal Stem Cells; Mice; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Phenelzine; Tranylcypromine

2013
Reversible and irreversible small molecule inhibitors of monoamine oxidase B (MAO-B) investigated by biophysical techniques.
    Bioorganic & medicinal chemistry, 2015, Feb-15, Volume: 23, Issue:4

    Topics: Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Parkinson Disease; Small Molecule Libraries; Thermodynamics

2015
Steroid regulation of monoamine oxidase activity in the adrenal medulla.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1989, Volume: 3, Issue:6

    Topics: Adrenal Medulla; Animals; Cattle; Chromaffin System; Clorgyline; Dexamethasone; DNA; Endothelium; Estradiol; Hydrocortisone; Kinetics; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Phenelzine; Progesterone; Protein Biosynthesis; Selegiline; Steroids; Testosterone

1989
Amine oxidase released into plasma of rats treated with hepatotoxin allyl formate.
    Research communications in chemical pathology and pharmacology, 1989, Volume: 66, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Clonidine; Formates; Formic Acid Esters; Kinetics; Male; Microsomes, Liver; Mitochondria, Liver; Monoamine Oxidase Inhibitors; Oxidoreductases Acting on CH-NH Group Donors; Phenelzine; Rats; Rats, Inbred Strains; Selegiline; Semicarbazides

1989
Inhibition of monoamine oxidase in monoaminergic neurones in the rat brain by irreversible inhibitors.
    Biochemical pharmacology, 1986, Apr-15, Volume: 35, Issue:8

    Topics: Animals; Brain; Clorgyline; Dose-Response Relationship, Drug; Hydrazines; Hypothalamus; Iproniazid; Male; Monoamine Oxidase Inhibitors; Phenelzine; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Serotonin; Reserpine; Selegiline; Tranylcypromine

1986
Serotoninergic but not noradrenergic neurons in rat central nervous system adapt to long-term treatment with monoamine oxidase inhibitors.
    Neuroscience, 1985, Volume: 16, Issue:4

    Topics: Animals; Clonidine; Clorgyline; Locus Coeruleus; Male; Monoamine Oxidase Inhibitors; Norepinephrine; Phenelzine; Raphe Nuclei; Rats; Rats, Inbred Strains; Selegiline; Serotonin; Synaptic Transmission

1985
Effect of antidepressant and narcoleptic drugs on N-isopropyl p-iodoamphetamine biodistribution in animals.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1987, Volume: 28, Issue:3

    Topics: Amphetamines; Animals; Drug Interactions; Imipramine; Iodine Radioisotopes; Iofetamine; Male; Phenelzine; Phenethylamines; Rabbits; Rats; Receptors, Adrenergic, beta; Receptors, GABA-A; Receptors, Muscarinic; Selegiline; Tissue Distribution

1987
Mysterious MAOI hypertensive episodes.
    The Journal of clinical psychiatry, 1986, Volume: 47, Issue:11

    Topics: Adult; Anxiety Disorders; Humans; Hypertension; Male; Monoamine Oxidase Inhibitors; Panic; Phenelzine; Phenethylamines; Selegiline; Tranylcypromine

1986
Binding of [14C] allylamine to isolated mitochondria from rat heart and aorta.
    Toxicology, 1987, Volume: 44, Issue:1

    Topics: Allylamine; Amines; Animals; Aorta; Binding Sites; Carbon Radioisotopes; In Vitro Techniques; Male; Mitochondria, Heart; Mitochondria, Muscle; Monoamine Oxidase; Phenelzine; Rats; Rats, Inbred Strains; Selegiline; Type C Phospholipases

1987
Role of benzylamine oxidase in the cytotoxicity of allylamine toward aortic smooth muscle cells.
    Toxicology, 1988, Volume: 51, Issue:2-3

    Topics: Allylamine; Amines; Animals; Aorta; Aorta, Thoracic; Benzylamine Oxidase; Cell Survival; Cells, Cultured; Male; Monoamine Oxidase; Muscle, Smooth, Vascular; Phenelzine; Selegiline; Semicarbazides; Subcellular Fractions; Swine; Uridine

1988
Reversible, enzyme-activated monoamine oxidase inhibitors: new advances.
    Pharmacological research communications, 1988, Volume: 20 Suppl 4

    Topics: Animals; Benzamides; Brain; Clorgyline; Humans; In Vitro Techniques; Male; Moclobemide; Monoamine Oxidase Inhibitors; Phenelzine; Picolinic Acids; Piperidines; Rats; Selegiline

1988
The dexamethasone suppression test in depressive illness: clinical correlates.
    Psychoneuroendocrinology, 1982, Volume: 7, Issue:4

    Topics: Depressive Disorder; Desipramine; Dexamethasone; Diagnosis, Differential; Double-Blind Method; Doxepin; Electroconvulsive Therapy; Female; Humans; Hydrocortisone; Imipramine; Male; Mianserin; Middle Aged; Nortriptyline; Phenelzine; Psychiatric Status Rating Scales; Selegiline

1982
Neuroprotective effects of some monoamine oxidase-B inhibitors against DSP-4-induced noradrenaline depletion in the mouse hippocampus.
    Journal of neurochemistry, 1994, Volume: 63, Issue:5

    Topics: Animals; Benzylamines; Desipramine; Dose-Response Relationship, Drug; Drug Interactions; Hippocampus; Male; Mice; Monoamine Oxidase Inhibitors; Neurons; Neurotransmitter Uptake Inhibitors; Norepinephrine; Pargyline; Phenelzine; Propylamines; Selegiline; Time Factors

1994
Induction of functional down-regulation of beta-adrenoceptors in rats by 2-phenylethylamine.
    Journal of pharmaceutical sciences, 1993, Volume: 82, Issue:1

    Topics: Albuterol; Animals; Behavior, Animal; Brain; Down-Regulation; Male; Monoamine Oxidase; Motor Activity; Phenelzine; Phenethylamines; Psychotropic Drugs; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Selegiline

1993
GABA-elevating effects of the antidepressant/antipanic drug phenelzine in brain: effects of pretreatment with tranylcypromine, (-)-deprenyl and clorgyline.
    Journal of affective disorders, 1995, Dec-13, Volume: 35, Issue:3

    Topics: 4-Aminobutyrate Transaminase; Animals; Antidepressive Agents; Brain; Clorgyline; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Isoenzymes; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Phenelzine; Premedication; Rats; Rats, Sprague-Dawley; Selegiline; Tranylcypromine

1995
Effects of MAO inhibitors upon MPTP mice chronically treated with suprathreshold doses of L-dopa.
    Behavioural pharmacology, 2000, Volume: 11, Issue:7-8

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Behavior, Animal; Clorgyline; Corpus Striatum; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Levodopa; Locomotion; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Motor Activity; Phenelzine; Phenethylamines; Selegiline; Thiazoles; Tryptamines

2000
Leading the way: advances in the diagnosis, treatment, and management of neuropsychiatric illnesses.
    CNS spectrums, 2006, Volume: 11, Issue:5

    Topics: Administration, Cutaneous; Administration, Topical; Brain; Depressive Disorder, Major; Humans; Mental Disorders; Monoamine Oxidase Inhibitors; Phenelzine; Psychiatry; Selegiline; Somatoform Disorders; Tranylcypromine

2006
Amine oxidases and their inhibitors: what can they tell us about neuroprotection and the development of drugs for neuropsychiatric disorders?
    Journal of psychiatry & neuroscience : JPN, 2007, Volume: 32, Issue:5

    Topics: Amine Oxidase (Copper-Containing); Antidepressive Agents; Humans; Mental Disorders; Moclobemide; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Phenelzine; RNA, Messenger; Selegiline; Tranylcypromine

2007
Long-term administration of monoamine oxidase inhibitors alters the firing rate and pattern of dopamine neurons in the ventral tegmental area.
    The international journal of neuropsychopharmacology, 2009, Volume: 12, Issue:4

    Topics: Animals; Clorgyline; Dopamine; Electrophysiology; Evoked Potentials; Male; Monoamine Oxidase Inhibitors; Neurons; Norepinephrine; Phenelzine; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin, 5-HT3; Selegiline; Serotonin; Serotonin Antagonists; Ventral Tegmental Area

2009
Monoamine oxidase inhibitors revisited: what you should know.
    The Journal of clinical psychiatry, 2013, Volume: 74, Issue:2

    Topics: Antidepressive Agents; Depressive Disorder; Drug Therapy, Combination; Humans; Isocarboxazid; Monoamine Oxidase Inhibitors; Phenelzine; Selegiline; Tranylcypromine; Tyramine

2013
Evaluation of metabolism dependent inhibition of CYP2B6 mediated bupropion hydroxylation in human liver microsomes by monoamine oxidase inhibitors and prediction of potential as perpetrators of drug interaction.
    Chemico-biological interactions, 2015, Mar-25, Volume: 230

    Topics: Bupropion; Clorgyline; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2B6 Inhibitors; Drug Interactions; Glutathione; Humans; Hydroxylation; Inhibitory Concentration 50; Kinesics; Microsomes, Liver; Monoamine Oxidase Inhibitors; Pargyline; Phenelzine; Selegiline

2015