phenelzine and clorgyline

phenelzine has been researched along with clorgyline in 29 studies

Research

Studies (29)

TimeframeStudies, this research(%)All Research%
pre-199013 (44.83)18.7374
1990's5 (17.24)18.2507
2000's6 (20.69)29.6817
2010's4 (13.79)24.3611
2020's1 (3.45)2.80

Authors

AuthorsStudies
Dansette, PM; Fontana, E; Poli, SM1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M1
Almos, T; Edmondson, DE; Massari, ME; Rojas, RJ; Scott, R1
Jounela, AJ; Knoll, J; Mattila, MJ1
Banerjee, DK; Kelner, K; Offutt, L; Pollard, HB; Youdim, MB1
Fagervall, I; Ross, SB1
Blier, P; de Montigny, C1
Cesura, AM; Da Prada, M; Kettler, R; Richards, JG1
Dowson, JH1
Biziere, K; Kan, JP; Leclercq, J; Steinberg, R; Worms, P1
de Montigny, C; Descarries, L; Ferron, A; Reader, TA1
El Hait, MA; Green, AL1
Callingham, BA; Lyles, GA1
Ask, AL1
Callingham, BA; Clarke, DE; Lyles, GA1
Campbell, IC; Cohen, RM; Lipper, S; Murphy, DL; Pickar, D1
Allison, K; Greenshaw, AJ; Ivanová, S1
Alemany, R; García-Sevilla, JA; Olmos, G2
Klemfuss, H; Kripke, DF1
Baker, GB; Todd, KG1
Archer, T; Fredriksson, A; Palomo, T1
Elliot, DJ; Gillam, EM; Lewis, BC; Miners, JO; Polasek, TM; Somogyi, AA1
Bardo, MT; Wooters, TE1
Blier, P; Chenu, F; El Mansari, M1
Bhyrapuneni, G; Manoharan, A; Mohammed, AR; Nirogi, R; Palacharla, RC; Ponnamaneni, RK1
García-Fuster, MJ; García-Sevilla, JA1
Gaur, S; Gross, ME; Liao, CP; Qian, B; Shih, JC1
Antonarakis, ES; Chang, C; Chang, P; Huang, CP; Li, G; Lu, C; Luo, J; Meng, J; Niu, Y; Wang, K; Xu, W; Yeh, S; You, B; Zhu, Y1

Reviews

3 review(s) available for phenelzine and clorgyline

ArticleYear
Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.
    Current drug metabolism, 2005, Volume: 6, Issue:5

    Topics: Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; Isoenzymes; Structure-Activity Relationship; Terminology as Topic

2005
MAO inhibitors in mental disease: their current status.
    Journal of neural transmission. Supplementum, 1987, Volume: 23

    Topics: Benzamides; Clorgyline; Depressive Disorder; Drug Therapy, Combination; Humans; Moclobemide; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Phenelzine; Tranylcypromine

1987
[Interactions between monoaminergic neurons projecting to the cerebral cortex].
    L'union medicale du Canada, 1985, Volume: 114, Issue:12

    Topics: Animals; Cerebral Cortex; Clorgyline; Monoamine Oxidase Inhibitors; Phenelzine; Rats; Receptors, Adrenergic; Receptors, Serotonin; Selegiline

1985

Trials

1 trial(s) available for phenelzine and clorgyline

ArticleYear
Selective and nonselective monoamine oxidase inhibitors: behavioral disturbances during their administration to depressed patients.
    Archives of general psychiatry, 1982, Volume: 39, Issue:5

    Topics: Acute Disease; Adult; Affective Disorders, Psychotic; Bipolar Disorder; Clorgyline; Depressive Disorder; Double-Blind Method; Female; Humans; Male; Middle Aged; Pargyline; Phenelzine; Placebos; Propylamines; Time Factors

1982

Other Studies

25 other study(ies) available for phenelzine and clorgyline

ArticleYear
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
    Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21

    Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship

2008
Reversible and irreversible small molecule inhibitors of monoamine oxidase B (MAO-B) investigated by biophysical techniques.
    Bioorganic & medicinal chemistry, 2015, Feb-15, Volume: 23, Issue:4

    Topics: Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Parkinson Disease; Small Molecule Libraries; Thermodynamics

2015
Interaction of selective inhibitors of monoamine oxidase with pethidine in rabbits.
    Biochemical pharmacology, 1977, Apr-15, Volume: 26, Issue:8

    Topics: Animals; Body Temperature; Clorgyline; Female; Hydroxyindoleacetic Acid; Hypothalamus; Male; Meperidine; Monoamine Oxidase Inhibitors; Phenelzine; Phenethylamines; Rabbits; Serotonin

1977
Steroid regulation of monoamine oxidase activity in the adrenal medulla.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1989, Volume: 3, Issue:6

    Topics: Adrenal Medulla; Animals; Cattle; Chromaffin System; Clorgyline; Dexamethasone; DNA; Endothelium; Estradiol; Hydrocortisone; Kinetics; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Phenelzine; Progesterone; Protein Biosynthesis; Selegiline; Steroids; Testosterone

1989
Inhibition of monoamine oxidase in monoaminergic neurones in the rat brain by irreversible inhibitors.
    Biochemical pharmacology, 1986, Apr-15, Volume: 35, Issue:8

    Topics: Animals; Brain; Clorgyline; Dose-Response Relationship, Drug; Hydrazines; Hypothalamus; Iproniazid; Male; Monoamine Oxidase Inhibitors; Phenelzine; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Serotonin; Reserpine; Selegiline; Tranylcypromine

1986
Serotoninergic but not noradrenergic neurons in rat central nervous system adapt to long-term treatment with monoamine oxidase inhibitors.
    Neuroscience, 1985, Volume: 16, Issue:4

    Topics: Animals; Clonidine; Clorgyline; Locus Coeruleus; Male; Monoamine Oxidase Inhibitors; Norepinephrine; Phenelzine; Raphe Nuclei; Rats; Rats, Inbred Strains; Selegiline; Serotonin; Synaptic Transmission

1985
Reversible, enzyme-activated monoamine oxidase inhibitors: new advances.
    Pharmacological research communications, 1988, Volume: 20 Suppl 4

    Topics: Animals; Benzamides; Brain; Clorgyline; Humans; In Vitro Techniques; Male; Moclobemide; Monoamine Oxidase Inhibitors; Phenelzine; Picolinic Acids; Piperidines; Rats; Selegiline

1988
Monoamine oxidase-inhibiting properties of SR 95191, a new pyridazine derivative, in the rat: evidence for selective and reversible inhibition of monoamine oxidase type A in vivo but not in vitro.
    Journal of neurochemistry, 1988, Volume: 50, Issue:4

    Topics: Animals; Brain; Clorgyline; Corpus Striatum; Dialysis; Dopamine; Dose-Response Relationship, Drug; Duodenum; Kinetics; Liver; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Phenelzine; Phenethylamines; Pyridazines; Rats; Rats, Inbred Strains; Serotonin; Tetrabenazine

1988
p-Methoxyamphetamine, a potent reversible inhibitor of type-A monoamine oxidase in vitro and in vivo.
    The Journal of pharmacy and pharmacology, 1980, Volume: 32, Issue:4

    Topics: Amphetamine; Amphetamines; Animals; Brain; Clorgyline; Dose-Response Relationship, Drug; In Vitro Techniques; Kinetics; Male; Mice; Monoamine Oxidase Inhibitors; Phenelzine; Rats; Serotonin; Structure-Activity Relationship; Substrate Specificity

1980
Hydralazine is an irreversible inhibitor of the semicarbazide-sensitive, clorgyline-resistant amine oxidase in rat aorta homogenates.
    The Journal of pharmacy and pharmacology, 1982, Volume: 34, Issue:2

    Topics: Amine Oxidase (Copper-Containing); Animals; Aorta; Blood Vessels; Clorgyline; Hydralazine; In Vitro Techniques; Kinetics; Male; Oxidoreductases Acting on CH-NH Group Donors; Phenelzine; Rats; Rats, Inbred Strains; Semicarbazides

1982
Selective inhibition by amiflamine of monoamine oxidase type A in rat brain, liver and duodenum.
    Naunyn-Schmiedeberg's archives of pharmacology, 1984, Volume: 327, Issue:1

    Topics: Animals; Brain; Clorgyline; Deamination; Duodenum; In Vitro Techniques; Liver; Male; Mitochondria; Monoamine Oxidase Inhibitors; Phenelzine; Phenethylamines; Rats; Rats, Inbred Strains; Serotonin; Tyramine

1984
A comparison of cardiac and vascular clorgyline-resistant amine oxidase and monoamine oxidase. Inhibition by amphetamine, mexiletine and other drugs.
    Biochemical pharmacology, 1982, Jan-01, Volume: 31, Issue:1

    Topics: Animals; Aorta; Benzylamine Oxidase; Benzylamines; Clorgyline; Dextroamphetamine; Drug Resistance; Kinetics; Male; Mexiletine; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Myocardium; Phenelzine; Propylamines; Rats; Rats, Inbred Strains; Tyramine

1982
Behavioural response to SKF 38393 and quinpirole following chronic antidepressant treatment.
    European journal of pharmacology, 1995, Apr-24, Volume: 277, Issue:2-3

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Analysis of Variance; Animals; Antidepressive Agents; Behavior, Animal; Clomipramine; Clorgyline; Desipramine; Dopamine Agonists; Ergolines; Grooming; Infusion Pumps, Implantable; Male; Monoamine Oxidase; Motor Activity; Phenelzine; Quinpirole; Rats; Rats, Sprague-Dawley; Yawning

1995
Chronic treatment with phenelzine and other irreversible monoamine oxidase inhibitors downregulates I2-imidazoline receptors in the brain and liver.
    Annals of the New York Academy of Sciences, 1995, Jul-12, Volume: 763

    Topics: Animals; Brain; Clorgyline; Cytochrome P-450 Enzyme System; Down-Regulation; Enzyme Induction; Imidazoles; Imidazoline Receptors; Isocarboxazid; Liver; Male; Monoamine Oxidase Inhibitors; Phenelzine; Rats; Rats, Sprague-Dawley; Receptors, Drug; Tranylcypromine

1995
The effects of phenelzine and other monoamine oxidase inhibitor antidepressants on brain and liver I2 imidazoline-preferring receptors.
    British journal of pharmacology, 1995, Volume: 114, Issue:4

    Topics: Adrenergic alpha-Antagonists; Animals; Antidepressive Agents; Benzamides; Binding, Competitive; Brain; Chlorphenamidine; Clorgyline; Cytochrome P-450 Enzyme System; Dioxanes; Idazoxan; Imidazoles; Imidazoline Receptors; In Vitro Techniques; Injections, Intraperitoneal; Isocarboxazid; Liver; Male; Moclobemide; Monoamine Oxidase Inhibitors; Pargyline; Phenelzine; Propylamines; Rats; Rats, Sprague-Dawley; Receptors, Drug; Tranylcypromine

1995
Antidepressant and depressogenic drugs lack consistent effects on hamster circadian rhythms.
    Psychiatry research, 1994, Volume: 53, Issue:2

    Topics: Animals; Antidepressive Agents; Arousal; Circadian Rhythm; Clonidine; Clorgyline; Cricetinae; Desipramine; Dose-Response Relationship, Drug; Fluoxetine; Male; Mesocricetus; Motor Activity; Phenelzine; Propranolol

1994
GABA-elevating effects of the antidepressant/antipanic drug phenelzine in brain: effects of pretreatment with tranylcypromine, (-)-deprenyl and clorgyline.
    Journal of affective disorders, 1995, Dec-13, Volume: 35, Issue:3

    Topics: 4-Aminobutyrate Transaminase; Animals; Antidepressive Agents; Brain; Clorgyline; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Isoenzymes; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Phenelzine; Premedication; Rats; Rats, Sprague-Dawley; Selegiline; Tranylcypromine

1995
Effects of MAO inhibitors upon MPTP mice chronically treated with suprathreshold doses of L-dopa.
    Behavioural pharmacology, 2000, Volume: 11, Issue:7-8

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Behavior, Animal; Clorgyline; Corpus Striatum; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Levodopa; Locomotion; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Motor Activity; Phenelzine; Phenethylamines; Selegiline; Thiazoles; Tryptamines

2000
An evaluation of potential mechanism-based inactivation of human drug metabolizing cytochromes P450 by monoamine oxidase inhibitors, including isoniazid.
    British journal of clinical pharmacology, 2006, Volume: 61, Issue:5

    Topics: Aryl Hydrocarbon Hydroxylases; Clorgyline; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; Isoniazid; Microsomes, Liver; Mixed Function Oxygenases; Monoamine Oxidase Inhibitors; Phenelzine; Tissue Culture Techniques; Ultrafiltration

2006
The monoamine oxidase inhibitor phenelzine enhances the discriminative stimulus effect of nicotine in rats.
    Behavioural pharmacology, 2007, Volume: 18, Issue:7

    Topics: Animals; Clorgyline; Conditioning, Operant; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Drug Synergism; Isoenzymes; Male; Monoamine Oxidase Inhibitors; Nicotine; Nicotinic Agonists; Pargyline; Phenelzine; Rats; Rats, Sprague-Dawley; Self Administration

2007
Long-term administration of monoamine oxidase inhibitors alters the firing rate and pattern of dopamine neurons in the ventral tegmental area.
    The international journal of neuropsychopharmacology, 2009, Volume: 12, Issue:4

    Topics: Animals; Clorgyline; Dopamine; Electrophysiology; Evoked Potentials; Male; Monoamine Oxidase Inhibitors; Neurons; Norepinephrine; Phenelzine; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin, 5-HT3; Selegiline; Serotonin; Serotonin Antagonists; Ventral Tegmental Area

2009
Evaluation of metabolism dependent inhibition of CYP2B6 mediated bupropion hydroxylation in human liver microsomes by monoamine oxidase inhibitors and prediction of potential as perpetrators of drug interaction.
    Chemico-biological interactions, 2015, Mar-25, Volume: 230

    Topics: Bupropion; Clorgyline; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2B6 Inhibitors; Drug Interactions; Glutathione; Humans; Hydroxylation; Inhibitory Concentration 50; Kinesics; Microsomes, Liver; Monoamine Oxidase Inhibitors; Pargyline; Phenelzine; Selegiline

2015
Effects of anti-depressant treatments on FADD and p-FADD protein in rat brain cortex: enhanced anti-apoptotic p-FADD/FADD ratio after chronic desipramine and fluoxetine administration.
    Psychopharmacology, 2016, Volume: 233, Issue:15-16

    Topics: Adrenergic alpha-Antagonists; Animals; Antidepressive Agents; Apoptosis; Autoreceptors; Blotting, Western; Brain; CASP8 and FADD-Like Apoptosis Regulating Protein; Cerebral Cortex; Clorgyline; Desipramine; Electroshock; Excitatory Amino Acid Antagonists; Fas-Associated Death Domain Protein; Fluoxetine; Idazoxan; Indans; Ketamine; Male; Mianserin; Mirtazapine; Monoamine Oxidase Inhibitors; Norepinephrine Plasma Membrane Transport Proteins; Phenelzine; Phosphoproteins; Phosphorylation; Rats; RNA-Binding Proteins; Thiazoles

2016
Effect of Monoamine oxidase A (MAOA) inhibitors on androgen-sensitive and castration-resistant prostate cancer cells.
    The Prostate, 2019, Volume: 79, Issue:6

    Topics: Androgen Antagonists; Benzamides; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Clorgyline; Drug Resistance, Neoplasm; Humans; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neoplasm Grading; Nitriles; Phenelzine; Phenylthiohydantoin; Prostate; Prostatic Neoplasms, Castration-Resistant; Receptors, Androgen

2019
The MAO inhibitors phenelzine and clorgyline revert enzalutamide resistance in castration resistant prostate cancer.
    Nature communications, 2020, 06-01, Volume: 11, Issue:1

    Topics: Alternative Splicing; Animals; Benzamides; Cell Line, Tumor; Cell Proliferation; Clorgyline; Drug Resistance, Neoplasm; Enzyme Stability; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; Mice, Nude; Mice, SCID; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neoplastic Cells, Circulating; Nitriles; Phenelzine; Phenylthiohydantoin; Prostatic Neoplasms, Castration-Resistant; Receptors, Androgen; Signal Transduction; Up-Regulation; Xenograft Model Antitumor Assays

2020