phenazocine has been researched along with 2'-hydroxy-5,9-dimethyl-2-allyl-6,7-benzomorphan in 395 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 192 (48.61) | 18.7374 |
| 1990's | 143 (36.20) | 18.2507 |
| 2000's | 39 (9.87) | 29.6817 |
| 2010's | 19 (4.81) | 24.3611 |
| 2020's | 2 (0.51) | 2.80 |
| Authors | Studies |
|---|---|
| Coale, EH; Hein, DW; Herling, S; Valentino, RJ; Woods, JH | 1 |
| Samovilova, NN; Vinogradov, VA | 1 |
| Grynne, BH; Holmen, AT; Maurset, A | 1 |
| Berzetei-Gurske, IP; Toll, L | 1 |
| Abraham, P; Bai, X; Brine, GA; Carroll, FI; Martin, BR; Mascarella, SW; May, EL; Parham, K; Sauss, C; Zhang, X | 1 |
| Maneckjee, R; Minna, JD | 1 |
| Lemaire, S; Rogers, C | 1 |
| Hudzik, TJ | 1 |
| Bassi, D; Faletti, A; Gimeno, AL; Gimeno, MA | 1 |
| Cook, L; Gilligan, PJ; Schmidt, WK; Steinfels, GF; Tam, SW | 1 |
| Culp, SG; De Souza, EB; Rominger, D; Tam, SW | 1 |
| Beaton, JA; Monaghan, DT; Stemsrud, K | 1 |
| Hudzik, TJ; Slifer, BL | 1 |
| McCann, DJ; Su, TP | 4 |
| Hitosugi, H; Iwamoto, Y; Kamei, J; Kasuya, Y; Kawashima, N; Misawa, M | 1 |
| Borsini, F; Ceci, A; Volonté, M | 2 |
| Feuerstein, G; Gu, JL; Lysko, PG; Yue, TL | 1 |
| Feuerstein, G; Gagnon, RC; Gu, JL; Lysko, PG; Yue, TL | 1 |
| Matsunaga, K; Matsuno, K; Mita, S | 1 |
| Mitchell, KN; Tam, SW | 1 |
| Angulo, JA; Ledoux, M; McEwen, BS | 1 |
| Boyce, S; Cook, G; Iversen, SD; Rupniak, NM; Steventon, MJ | 1 |
| Ross, SB | 1 |
| Bridges, RS; Kinsley, CH; Mann, PE | 1 |
| Chiba, S; Nishida, N; Yasuhara, Y | 1 |
| deCosta, BR; Hardwick, WC; McMillan, DE; Rice, KC | 1 |
| Katki, AG; Munson, PJ; Rodbard, D; Schwarz, S; Zhou, GZ | 1 |
| Dumont, M; Lemaire, S | 1 |
| Karbon, EW; Naper, K; Pontecorvo, MJ | 1 |
| Burke, M; Earley, B; Gouret, CJ; Junien, JL; Leonard, BE | 2 |
| Carter, AJ; Müller, RE | 1 |
| Balestra, B; Candura, SM; Coccini, T; Costa, LG; Iapadre, N; Manzo, L; Tonini, M | 1 |
| Baldessarini, RJ; Booth, RG | 1 |
| Gillard, J; Knight, AR; Middlemiss, DN; Wong, EH | 1 |
| Pèzzola, A; Popoli, P; Sagratella, S; Scotti de Carolis, A | 1 |
| Brent, PJ | 1 |
| Contreras, PC; Dilworth, VM; Farah, JM; Gray, NM; Iyengar, S; Mick, SJ; Rao, TS; Wood, PL | 1 |
| Duckles, SP; Massamiri, T | 2 |
| Cristante, D; Itzhak, Y; Kassim, CO; Stein, I; Zhang, SH | 1 |
| Bell, JA; London, ED; Spivak, CE; Su, TP; Wu, XZ | 1 |
| Dykstra, LA; Picker, MJ; Powell, K | 1 |
| Contreras, PC; Dilworth, VM; Iyengar, S; Mick, SJ; Monahan, JB; Rao, TS; Wood, PL | 1 |
| Henderson, G; Jarvis, GE; Kennedy, C | 1 |
| Junien, JL; Martin, B; Pascaud, X; Roman, FJ; Vauché, D | 1 |
| Feuerstein, G; Lysko, PG | 1 |
| Connick, JH; Fox, PK; France, L; Hanlon, GM; Nicholson, CD | 1 |
| Cone, EJ; Johnson, RE; Su, TP; Vaupel, DB | 1 |
| Su, TP; Wu, XZ | 1 |
| Bowen, WD; DeCosta, B; Hellewell, SB; Rice, KC; Thurkauf, A; Walker, JM | 1 |
| Dilworth, V; Farah, JM; Iyengar, S; Michel, J; Mick, S; Rao, TS; Wood, PL | 1 |
| Kesingland, AC; Singh, L; Tricklebank, MD; Wong, EH | 1 |
| Bejanian, M; George, R; Pechnick, RN | 2 |
| Bauerle, LM; DeNoble, VJ; Jones, KW | 1 |
| Bueno, L; Fioramonti, J; Gue, M; Junien, JL; Pascaud, X | 1 |
| Defaux, JP; Junien, JL; Pascaud, X; Rozé, C | 1 |
| Goldberg, SR; Schindler, CW; White, MF | 1 |
| Beinfeld, MC; Brog, JS | 1 |
| Barnette, MS; Barone, FC; Callahan, JF; Grous, M; Manning, CD | 1 |
| Katki, AG; Rodbard, D; Schwarz, S; Zhou, GZ | 1 |
| DeLander, GE; Wahl, JJ | 1 |
| Balster, RL | 2 |
| Iwamoto, ET | 3 |
| Oswald, RE; Papke, RL | 1 |
| Ahier, RG; Middlemiss, DN; Price, GW; Singh, L; Tricklebank, MD; Wong, EH | 1 |
| France, CP; Snyder, AM; Woods, JH | 1 |
| Kobylyansky, AG | 1 |
| Alerhand, S; Itzhak, Y | 1 |
| Bowen, WD; Hellewell, SB; McGarry, KA | 1 |
| Cheng, BK; Contreras, PC; Gray, NM; Lair, CM; Mick, SJ | 1 |
| Cécyre, D; Lemaire, S; Rogers, C | 1 |
| Wann, KT; Wardley-Smith, B | 1 |
| Iversen, SD; Oles, RJ; Preston, C; Singh, L; Tricklebank, MD | 1 |
| Campbell, BG; Galligan, JJ; Kavanaugh, MP; North, RA; Weber, E | 1 |
| Iarygin, KN; Kaliuzhnyĭ, AE; Sukhikh, GT | 1 |
| Balster, RL; Willetts, J | 1 |
| Vaupel, DB | 2 |
| Gussio, RP; Marquis, KL; Moreton, JE; Paquette, NC | 1 |
| Allikmets, LKh; Kharro, IaE; Lang, AE; Vasar, EE | 1 |
| Duffy, O; Junien, JL; Martin, B; Pascaud, X; Roman, FJ; Vauche, D | 1 |
| Clow, DW; Jhamandas, K | 1 |
| Jackson, A; Sanger, DJ | 3 |
| Beart, PM; Manallack, DT; O'Shea, RD | 1 |
| Martin, WR; Wu, KM | 2 |
| McMillan, DE; Wessinger, WD | 1 |
| Foster, AC; Gill, R; Iversen, LL; Kemp, JA; Wong, EH; Woodruff, GN | 1 |
| Bronson, ME; Moerschbaecher, JM | 1 |
| Cook, L; Steinfels, GF; Tam, SW | 3 |
| Iversen, SD; Oles, RJ; Singh, L; Tricklebank, MD; Wong, EH | 1 |
| Catt, KJ; Dufau, ML; Stojilković, SS | 1 |
| Knight, AR; Wong, EH; Woodruff, GN | 1 |
| Beart, PM; Manallack, DT | 1 |
| Jaffe, JH; London, ED; Su, TP | 1 |
| Itzhak, Y; Khouri, M | 1 |
| Junien, JL; Pascaud, X; Roman, F; Vauché, D | 1 |
| Kamei, H; Kameyama, T; Nabeshima, T | 4 |
| Korobov, NV; Nagornaia, LV; Samovilova, NN; Vinogradov, VA | 1 |
| Bidlack, JM; Tyler, CB | 1 |
| Kushner, L; Zukin, RS; Zukin, SR | 1 |
| Contreras, PC; DiMaggio, DA; O'Donohue, TL | 1 |
| Alberici, GP; Cook, L; Steinfels, GF; Tam, SW | 1 |
| Carino, MA; Horita, A; Yamawaki, S | 1 |
| Holtzman, SG | 3 |
| Cooper, SJ; Jackson, A; Kirkham, TC | 1 |
| Downes, CP; Lewis, PE; Stone, MA | 1 |
| French, ED | 1 |
| Chang, KJ; Ferris, RM; Russell, A; Tang, FL | 1 |
| Chung, JM; Kim, J; Shin, HK; Willcockson, WS; Willis, WD | 1 |
| Su, TP | 3 |
| Itoh, Y; Nishibori, M; Oishi, R; Saeki, K | 1 |
| Braunwalder, AF; Lehmann, J; Loo, PS; Sills, MA; Williams, M | 1 |
| Itzhak, Y | 2 |
| Furukawa, H; Hiramatsu, M; Kameyama, T; Nabeshima, T | 1 |
| Cohen, S; Ouyang, A; Vos, P | 1 |
| Ford-Rice, FY; London, ED; Schell, SE; Su, TP | 1 |
| Ceci, A; French, ED; Smith, M | 1 |
| Adler, MW; Geller, EB; Rowan, CH | 1 |
| Bidlack, JM; Selley, DE; Tyler, CB | 1 |
| George, R; Pechnick, R; Poland, RE | 2 |
| Adler, MW; Geller, EB; Kirby, A; Messner, S; Robin, M | 1 |
| Lahti, RA; Mickelson, MM | 2 |
| Calligaro, D; el-Fakahany, EE; Hong, O; Khazan, N; Young, GA | 1 |
| Johnson, BG; Kalra, V; Kerchner, GA; Mendelsohn, LG | 1 |
| Eisenberg, RM | 1 |
| Gundlach, AL; Largent, BL; Snyder, SH | 3 |
| Goldman, ME; Jacobson, AE; Paul, SM; Rice, KC | 1 |
| Starr, MS | 1 |
| Iarygin, KN; Samovilova, NN; Vinogradov, VA | 1 |
| Greenberg, BD; Segal, DS | 1 |
| Gardner, EL; Tempel, A; Zukin, RS; Zukin, SR | 1 |
| Jacobson, AE; Koek, W; Lessor, RA; Rice, KC; Woods, JH | 1 |
| DeRossett, SE; Holtzman, SG | 1 |
| Ieni, JR; Nichtenhauser, R; Sircar, R; Zukin, SR | 1 |
| Su, TP; Weissman, AD; Yeh, SY | 1 |
| Sircar, R; Zukin, SR | 1 |
| Contreras, PC; O'Donohue, TL; Quirion, R | 1 |
| Hiramatsu, M; Kameyama, T; Nabeshima, T | 2 |
| Dykstra, LA; Slifer, BL | 2 |
| Bagley, RB; Compton, DR; Katzen, JS; Martin, BR | 1 |
| Hong, O; Khazan, N; Young, GA | 1 |
| Coan, EJ; Collingridge, GL | 1 |
| Carroll, ME | 1 |
| Giles, TD; Given, MB; Lowe, RF; Sander, GE | 1 |
| Bartschat, DK; Blaustein, MP | 1 |
| Dzhumbaev, SU; Egamov, IuS; Polonskiĭ, VM; Vinogradov, VA | 1 |
| Dykstra, LA; Picker, M | 1 |
| Nagornaya, LV; Samovilova, NN; Vinogradov, VA | 1 |
| Cristofori, P; Siniscalchi, A; Veratti, E | 1 |
| Iversen, LL; Kemp, JA; Knight, AR; Priestley, T; Wong, EH; Woodruff, GN | 1 |
| Gormezano, I; Harvey, JA; Lamb, MR; Schindler, CW | 1 |
| Dykstra, LA; Heise, JW; Picker, M | 1 |
| Coleman, BA; Michel, L; Oswald, R | 1 |
| McCann, DJ; Rabin, RA; Winter, JC | 1 |
| Iarygin, KN; Kryzhanovskiĭ, GN; Sukhikh, GT; Vinogradov, VA | 1 |
| Kozlowski, MR | 1 |
| Mattia, A; Moreton, JE | 1 |
| Bakalkin, GIa; Cherdantsev, VG; Fitin, AF; Kaliuzhnyĭ, AE | 1 |
| Risner, ME; Shannon, HE; Vaupel, DB | 1 |
| McLaughlin, JT; Oswald, RE; Pennow, NN | 1 |
| Harris, LS; May, EL | 1 |
| Costa, T; Dunn, LL; Hubbell, CL; Hunter, GA; Reid, LD | 1 |
| Bigelow, J; Michel, L; Oswald, RE | 1 |
| McCann, DJ; Winter, JC | 1 |
| Leccese, AP; Marquis, KL; Mattia, A; Moreton, JE | 1 |
| Hiller, JM; Itzhak, Y; Simon, EJ | 1 |
| Clark, RD; Katz, JL; Spealman, RD | 1 |
| Bergman, J; Hassoun, J; Schuster, CR | 1 |
| Calligaro, D; El-Fakany, EE; Hong, O; Khazan, N; Young, GA | 1 |
| Berry, SC; Dawkins, SL; Lodge, D | 1 |
| Bunney, BS; Freeman, AS | 1 |
| Harris, LS; Katzen, JS; Martin, BR; May, EL; Tripathi, HL; Woods, JA | 1 |
| Khazan, N; Young, GA | 2 |
| Herz, A; Pfeiffer, A | 2 |
| Dawson, G; McLawhon, RW; Miller, RJ; West, RE | 1 |
| Zukin, RS; Zukin, SR | 1 |
| Miller, RJ | 1 |
| Hillman, GR; Johnson, KM | 1 |
| Tung, AS; Yaksh, TL | 1 |
| Cone, EJ; Goldberg, SR; Gorodetzky, CW; Herling, S; Risner, ME; Shannon, HE; Vaupel, DB | 1 |
| Ben-Sreti, MM; Gonzalez, JP; Sewell, RD | 1 |
| French, ED; Vantini, G | 1 |
| Enger, M; Grynne, BH; Holmen, AT; Maurset, AR | 1 |
| Cook, L; Tam, SW | 1 |
| Billington, CJ; Gerritsen, GC; Levine, AS; Morley, JE | 1 |
| Balster, RL; Brady, KT; Slifer, BL; Zukin, SR | 1 |
| Holtzman, SG; Teal, JJ | 1 |
| Rackham, A; Wood, PL | 1 |
| Bernardini, GL; Clark, WG; Ponder, SW | 1 |
| Carroll-Buatti, M; Pasternak, GW; Spiegel, K | 1 |
| Balster, RL; Brady, KT; May, EL | 1 |
| Harris, RA; Snell, D | 1 |
| Nishimura, S; Pasternak, GW; Wolozin, BL | 1 |
| Nishimura, S; Pasternak, GW | 1 |
| Herz, A; Shearman, GT | 1 |
| Guidotti, A; Saiani, L | 1 |
| Morton, EC; Vaupel, DB | 1 |
| Bearden, LJ; Snead, OC | 1 |
| Shannon, HE; Su, TP | 1 |
| Kandasamy, SB; Williams, BA | 1 |
| Balster, RL; Slifer, BL | 1 |
| Pert, CB; Quirion, R | 1 |
| Aceto, MD; Balster, RL; Harris, LS; Martin, BR | 1 |
| Cicero, TJ; Meyer, ER; Owens, DP; Schmoeker, PF | 1 |
| Johnson, N; Pasternak, GW | 1 |
| Aceto, MD; May, EL | 1 |
| Tam, SW | 1 |
| Gosnell, BA; Levine, AS; Morley, JE | 1 |
| Greenfield, LJ; Guyenet, PG; Hackett, JT; Stringer, JL | 1 |
| Stafford, I; Tomie, A; Wagner, GC | 1 |
| Code, RA; Tang, AH | 1 |
| Pilapil, C; Wood, PL | 1 |
| Bajorek, JG; Lee, RJ; Lomax, P | 1 |
| Holtzman, SG; White, JM | 2 |
| Johnson, KM; Leventer, SM | 1 |
| Mastropaolo, J; Moerschbaecher, JM; Thompson, DM; Winsauer, PJ | 1 |
| Commissaris, RL; Henck, JW; Mokler, DJ; Rech, RH | 1 |
| Contreras, CM; Ervin, FR; Guzman-Flores, C; Mexicano, G; Palmour, R | 1 |
| Colpaert, FC; Janssen, PA | 1 |
| Herling, S; Woods, JH | 1 |
| Cone, EJ; Croughan, JL; Goldberg, SR; Gorodetzky, CW; Risner, ME; Shannon, HE; Su, TP; Yeh, SY | 1 |
| Shannon, HE | 2 |
| Adler, MW; Geller, EB; Hawk, C; Keinath, SH; Tallarida, RJ | 1 |
| Carter, FE; Chau, TT; Harris, LS | 1 |
| Moerschbaecher, JM; Thompson, DM | 1 |
| Franklin, SR; Tang, AH | 1 |
| Eades, CG; Gilbert, PE; Martin, WR; Thompson, JA | 1 |
| Kromer, W; Shearman, GT; Steigemann, N | 1 |
| Cuomo, V; d'Istria, M; Maj, M; Monteleone, P; Serino, I; Steardo, L | 2 |
| Ohno, M; Watanabe, S | 1 |
| Bastianetto, S; Perrault, G; Sanger, DJ | 1 |
| Brent, PJ; Dunkley, PR; Haynes, H; Jarvie, PE; Mudge, L; Sim, AT | 1 |
| Appleyard, SM; Chavkin, C; Connor, M; Patterson, TA | 1 |
| Chariot, J; Nagain, C; Rozé, C | 1 |
| Arnold, FJ; Murphy, RB; Schuster, DI | 1 |
| DeCoster, MA; Klette, KL; Knight, ES; Tortella, FC | 1 |
| Matsunaga, KH; Matsuno, K; Mita, S | 1 |
| Bao, WL; Sun, FY; Zhang, AZ; Zhen, FC | 1 |
| Pechnick, RN; Poland, RE | 1 |
| Hasegawa, T; Hiramatsu, M; Itoh, J; Kameyama, T; Maurice, T; Nabeshima, T | 1 |
| Ginski, MJ; Witkin, JM | 1 |
| Holtzman, SG; Steinfels, GF | 1 |
| Ajima, A; Araki, H; Imagawa, Y; Muramatsu, M; Nakazato, A; Ogawa, S; Okuyama, S; Tanaka, M; Yamaguchi, K; Yoshida, M | 1 |
| Lysko, PG; Sauermelch, CF; Willette, RN | 1 |
| Gonzalez-Alvear, GM; Werling, LL | 1 |
| McCann, DJ; Su, TP; Weissman, AD | 1 |
| Matsunaga, K; Matsuno, K; Mita, S; Senda, T | 1 |
| Hara, H; Harada, Y; Sukamoto, T | 1 |
| Brent, PJ; Bunn, SJ; O'Malley, SR | 1 |
| Brent, PJ; Chahl, LA | 1 |
| DeSouza, EB; Grigoriadis, DE; Levant, B | 1 |
| Chaki, S; Imagawa, Y; Muramatsu, M; Okuyama, S; Otomo, S; Tanaka, M | 1 |
| Kaku, S; Muramatsu, M; Otomo, S; Tanaka, M | 1 |
| Glennon, RA; Herndon, JL; Young, R | 1 |
| Brusa, L; D'Amore, A; Lorenzini, P; Massotti, M | 1 |
| London, ED | 1 |
| De Souza, EB; Wolfe, SA | 1 |
| Shi, GG; Xu, SF | 1 |
| Chiou, GC; el Messiry, S; Rohde, BH; Zhu, M | 1 |
| Masaki, H; Mishina, M; Mori, H; Shimoji, K; Yamakura, T | 1 |
| Bouchard, P; Dumont, Y; Fournier, A; Quirion, R; St-Pierre, S | 1 |
| De Souza, EB; Hurt, SD; Rominger, D; Tam, SW; Watanabe, M | 1 |
| Coleman, BA; Oswald, RE | 1 |
| Matsuno, K; Mita, S; Senda, T | 1 |
| Junien, JL; Pascaud, X; Porreca, F; Rao, RK; Riviere, PJ | 1 |
| della Puppa, A; Kimes, AS; London, ED | 1 |
| Allen, JT; DeHaven-Hudkins, DL; Ford-Rice, FY; Hudkins, RL | 1 |
| Bergeron, R; Bouchard, P; de Montigny, C; Debonnel, G; Junien, JL; Monnet, F; Quirion, R; Roman, F | 1 |
| Kobayashi, T; Matsuno, K; Mita, S; Senda, T | 2 |
| Bouchard, P; Junien, JL; Quirion, R; Roman, F | 1 |
| Kobayashi, T; Matsuno, K; Mita, S | 3 |
| Bowen, WD; Torrence-Campbell, C | 1 |
| Darlington, CL; Jerram, AH; Smith, PF | 1 |
| Kobayashi, T; Matsuno, K; Mita, S; Nakata, K | 1 |
| Ichikawa, T; Ikeda, K; Kobayashi, T; Kumanishi, T; Togashi, S | 1 |
| Su, TP; Tsao, LI | 2 |
| Maurice, T; Privat, A; Roman, FJ; Su, TP | 1 |
| Amano, M; Matsuno, K; Nabeshima, T; Yamada, K | 1 |
| Maurice, T; Privat, A; Roman, FJ | 1 |
| Ha, BK; Saini, P; Whitlock, BB; Wolfe, SA | 1 |
| Furukawa, H; Hasegawa, T; Kitaichi, K; Nabeshima, T; Noda, Y | 1 |
| Jin, J; Watanabe, S; Yamamoto, T | 1 |
| Kamei, H; Kameyama, T; Nabeshima, T; Noda, Y | 1 |
| Mamede Rosa, ML; Prado, WA | 1 |
| Baskin, E; Bristow, LJ; Chapman, KL; Curtis, N; Emms, F; Fletcher, AE; Freedman, S; Graham, M; Knowles, M; Kulagowski, JJ; Leeson, PD; Lynch, JJ; Marwood, R; Matheson, S; Mcallister, G; Myers, J; Patel, S; Ragan, CI; Rathbone, D; Ridgill, M; Rupniak, NM; Watt, AP | 1 |
| Nabeshima, T; Yamada, K; Zou, LB | 1 |
| Kobayashi, T; Matsuno, K; Mita, S; Murai, M; Senda, T | 1 |
| Ahmed, MS; Enna, SJ; Mather, A | 1 |
| Bucolo, C; Cacciaguerra, S; Campana, G; Di Toro, R; Spampinato, S | 1 |
| Chen, Y; Jackson, MB; Lupardus, PJ; Mehta, RP; Ruoho, AE; Wilke, RA | 1 |
| Maurice, T; Phan, VL; Privat, A; Su, TP | 1 |
| Baulieu, EE; Collin, T; Denavit-Saubié, M; Monnet, FP; Morin-Surun, MP | 1 |
| Horikomi, K; Iizuka, K; Mita, N; Miwa, T; Nagase, H; Sakai, K; Sonehara, K; Takagi, K; Takahashi, S | 1 |
| Matsuno, K | 1 |
| Kamei, J | 1 |
| Kamei, H; Nabeshima, T; Noda, Y | 1 |
| Ishihara, K; Sasa, M | 1 |
| Akaike, A; Kaneko, S; Katsuki, H; Kume, T; Shimazu, S; Takenaka, C; Tomita, M | 1 |
| Bogomaz, SA; Gilligan, P; Lishmanov, IuB; Maslov, LN; Tam, SW | 1 |
| Garrone, B; Magnani, M; Pinza, M; Polenzani, L | 1 |
| Aydar, E; Chen, Y; Jackson, MB; Lupardus, PJ; Palmer, CP; Ruoho, AE; Wilke, RA | 1 |
| Kamei, H; Kamei, Y; Nabeshima, T; Nagai, T; Nishida, M; Noda, Y | 1 |
| Furukawa, S; Hiramatsu, M; Kameyama, T; Karasawa, K; Mamiya, T; Nabeshima, T; Noda, A; Noda, Y; Yamada, K | 1 |
| Akaike, A; Hashino, A; Kaneko, S; Katsuki, H; Kume, T; Nishikawa, H | 1 |
| Furukawa, H; Ichihara, K; Kamei, H; Mamiya, T; Nabeshima, T; Nagai, T; Noda, A; Noda, Y; Sugiura, S | 1 |
| Maurice, T; Phan, VL; Privat, A | 1 |
| Freeman, FM; Young, IG | 1 |
| Maurice, T; Phan, VL; Roman, FJ; Su, TP; Urani, A | 1 |
| Bridges, S; Miller, C; Thompson, TL | 1 |
| Guillemain, I; Maurice, T; Phan, VL; Urani, A | 1 |
| Dikranian, K; Farber, NB; Heinkel, C; Jiang, XP; Kim, SH | 1 |
| Aydar, E; Jackson, MB; Klyachko, VA; Palmer, CP | 1 |
| Horikomi, K; Karasawa, J; Sagi, N; Sora, I; Yamamoto, H; Yamamoto, T | 1 |
| Maurice, T; Phan, VL; Romieu, P; Urani, A | 1 |
| Horikomi, K; Karasawa, J; Takagi, K; Takahashi, S | 1 |
| Akaike, A; Hashino, A; Kaneko, S; Katsuki, H; Kume, T; Minami, M; Nishikawa, H; Satoh, M; Taguchi, R | 1 |
| David Clark, J; Demirci, H; Gharagozlou, P; Lameh, J | 1 |
| Chen, CF; Chien, JW; Chou, YC; Liao, JF; Wang, HH | 1 |
| Cantero, M; Codony, X; Cozar, P; Dordal, A; Giménez, E; Guitart, X; Hernández, E; Langa, F; Lavado, A; Monroy, X; Montoliu, L; Pérez, R; Tovar, V; Zamanillo, D | 1 |
| Brown, C; Ellis, JL; Fezoui, M; Schwartz, CE; Selig, WM | 1 |
| Kamei, H; Manh Tran, H; Maurice, T; Nabeshima, T; Nagai, T; Noda, Y; Roman, FJ; Romieu, P; Urani, A; Yamada, K | 1 |
| Dayag, M; Gil-Ad, I; Levkovitz, Y; Shtaif, B; Weizman, A; Zeldich, E | 1 |
| Chen, CF; Chou, YC; Liao, JF; Wang, HH | 1 |
| Hermans, E; Maloteaux, JM; Maurice, T; Peeters, M; Romieu, P; Su, TP | 1 |
| Sun, W; Wessinger, WD | 1 |
| Baeyens, JM; Cobos, EJ; Del Pozo, E | 1 |
| Maurice, T; Miyamoto, Y; Nabeshima, T; Phan, VL | 1 |
| Beltran, D; Cavas, M; Navarro, JF | 2 |
| Egashira, N; Fujiwara, M; Harada, S; Iwasaki, K; Matsushita, M; Mishima, K; Nishimura, R; Okuno, R; Orito, K | 1 |
| Baró, I; Bellocq, C; Bousquet, P; Ehrhardt, JD; Greney, H; Jaillon, P; Manoury, B; Monassier, L; Weissenburger, J; Zimmermann, D | 1 |
| Tanabe, M | 1 |
| Aydar, E; Djamgoz, MB; Mahen, R; Palmer, CP; Schnell, E | 1 |
| Tchedre, KT; Yorio, T | 1 |
| Dibas, A; Dillon, GH; Huang, RQ; Krishnamoorthy, RR; Tchedre, KT; Yorio, T | 1 |
| Hall, FS; Kitanaka, J; Kitanaka, N; Morita, Y; Nishiyama, N; Takemura, M; Tanaka, K; Tatsuta, T; Uhl, GR | 1 |
| Jackson, MB; Johannessen, M; Ramachandran, S; Ramos-Serrano, A; Riemer, L; Ruoho, AE | 1 |
| Botros, M; Carlsson, A; Fransson, R; Gordh, T; Hallberg, M; Nyberg, F; Sandström, A; Zhou, Q | 1 |
| Fontanilla, D; Jackson, MB; Johannessen, M; Mavlyutov, T; Ruoho, AE | 1 |
| Isotani, K; Mori, T; Narita, M; Nomura, M; Suzuki, T; Torigoe, K; Tsukiyama, Y; Yoshizawa, K | 1 |
| Ago, Y; Hiramatsu, N; Matsuda, T; Takuma, K; Yano, K | 1 |
| Lin, TY; Lu, CW; Wang, CC; Wang, SJ | 1 |
| De Ron, P; Delaunois, A; Detrait, E; Guyaux, M | 1 |
| Kim, FJ; Marino, JC; Pasternak, GW; Schrock, JM; Spino, CM | 1 |
| Hall, FS; Kitanaka, J; Kitanaka, N; Nishiyama, N; Takemura, M; Tanaka, K; Uhl, GR | 1 |
| Gao, XF; He, YL; Hu, C; Mei, YA; Yao, JJ | 1 |
| Akopova, I; Clark, AF; Daudt, DR; Ma, HY; Mueller, BH; Park, Y; Stankowska, DL; Yorio, T | 1 |
| Ago, Y; Hasebe, S; Hiramatsu, N; Matsuda, T; Mori, K; Nishimura, A; Takuma, K | 1 |
| Ahlskog, N; Beique, JC; Bergeron, R; Biscaro, D; Hristova, E; Nassrallah, W; Ngsee, JK; Pabba, M; Snyder, M; Wong, AY | 1 |
| Guo, L; Jiang, HF; Wang, Y; Zhang, A; Zhen, XC; Zheng, LT | 1 |
| Halberstadt, AL; Hyun, J; Powell, SB; Ruderman, MA | 1 |
| Ago, Y; Hasebe, S; Hashimoto, H; Hiramatsu, N; Matsuda, T; Mori, K; Onaka, Y; Takuma, K; Watabe, Y | 1 |
| Deng, QQ; Liu, LL; Weng, SJ; Yang, XL; Zhong, YM | 1 |
| Asano, M; Hide, I; Irifune, M; Katarao, K; Kawamoto, M; Motoike, S; Sakai, N; Tanaka, S; Urabe, T; Usuki, N; Yamamoto, H; Yokota, C | 1 |
| Guo, L; Jiang, HF; Ni, J; Wang, Y | 1 |
| Abraham, MJ; Bergeron, R; Fleming, KL; Raymond, S; Wong, AYC | 1 |
| Han, C; He, T; Waddington, JL; Wan, C; Wang, M; Zhen, X; Zhu, K | 1 |
| Chen, S; Feng, Y; Han, C; Hu, L; Huang, H; Lin, H; Ooi, K; Qian, X; Ren, X; Shi, Q; Wang, J; Wang, R; Xia, C; Zhu, D | 1 |
11 review(s) available for phenazocine and 2'-hydroxy-5,9-dimethyl-2-allyl-6,7-benzomorphan
| Article | Year |
|---|---|
The interaction between MK-801 and receptors for N-methyl-D-aspartate: functional consequences.
Topics: Anesthetics; Animals; Autoradiography; Cerebral Cortex; Choline O-Acetyltransferase; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Electrophysiology; Phenazocine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, sigma | 1987 |
Drug discrimination studies.
Topics: Analgesics, Opioid; Animals; Columbidae; Discrimination, Psychological; Dose-Response Relationship, Drug; Fentanyl; Generalization, Stimulus; Macaca mulatta; Morphine; Nalorphine; Naloxone; Naltrexone; Pentazocine; Phenazocine; Phencyclidine; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1985 |
Endorphins and food intake: kappa opioid receptor agonists and hyperphagia.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzodiazepines; Benzomorphans; Butorphanol; Choice Behavior; Cyclazocine; Diuresis; Drinking; Dynorphins; Eating; Endorphins; Ethylketocyclazocine; Humans; Morphine; Narcotic Antagonists; Phenazocine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Satiety Response | 1985 |
Multiple opiate receptors for multiple opioid peptides.
Topics: Animals; beta-Endorphin; Brain; Cyclazocine; Dogs; Drug Tolerance; Dynorphins; Endorphins; Ethylketocyclazocine; Male; Mice; Morphine; Naloxone; Neuromuscular Junction; Phenazocine; Rabbits; Radioligand Assay; Rats; Receptors, Opioid; Synaptic Transmission | 1982 |
Studies of sigma receptors and metabolic responses to sigma ligands in the brain.
Topics: Animals; Brain; Glucose; Haloperidol; Humans; Ligands; Phenazocine; Receptors, Phencyclidine; Receptors, sigma | 1993 |
Sigma and phencyclidine receptors in the brain-endocrine-immune axis.
Topics: Animals; Autoradiography; Brain Chemistry; Endocrine Glands; Humans; Hypophysectomy; Lymphocytes; Phenazocine; Phencyclidine; Receptors, Phencyclidine; Receptors, sigma | 1993 |
[Neuropharmacological effects of sigma receptor ligands: anxiolytic, anti-amnesic and neuroprotective effects].
Topics: Animals; Antipsychotic Agents; Anxiety; Brain Ischemia; Cinnamates; Cyclopropanes; Humans; Learning Disabilities; Memory Disorders; Phenazocine; Phencyclidine; Receptors, sigma | 1996 |
[Anti-amnesic effects of sigma (sigma)-receptor agonists].
Topics: Acetylcholine; Amnesia; Animals; Disease Models, Animal; Dopamine; Ligands; Mice; Morpholines; Pentazocine; Phenazocine; Piperazines; Receptors, sigma; Sigma-1 Receptor | 1999 |
[Possible role of sigma-receptors in the regulation of cough reflex, gastrointestinal and retinal function].
Topics: Animals; Anti-Ulcer Agents; Antitussive Agents; Carbazoles; Guanidines; Haloperidol; Humans; Ligands; Pentazocine; Phenazocine; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Retinal Diseases | 1999 |
[Sigma-receptor ligands and anti-stress actions].
Topics: Animals; Dehydroepiandrosterone; Dextromethorphan; Humans; Ligands; Mood Disorders; Neuropeptide Y; Phenazocine; Receptors, sigma; Sigma-1 Receptor; Stress, Physiological | 1999 |
[The function of sigma receptors--electrophysiological approach].
Topics: Animals; Electrophysiology; Guanidines; Hippocampus; Ligands; Phenazocine; Pyrimidines; Receptors, N-Methyl-D-Aspartate; Receptors, sigma | 1999 |
384 other study(ies) available for phenazocine and 2'-hydroxy-5,9-dimethyl-2-allyl-6,7-benzomorphan
| Article | Year |
|---|---|
Narcotic drug discriminations by rhesus monkeys and pigeons.
Topics: Animals; Columbidae; Cyclazocine; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Discrimination Learning; Dose-Response Relationship, Drug; Enkephalins; Ethylketocyclazocine; Etorphine; Hormones; Macaca; Macaca mulatta; Naltrexone; Narcotics; Phenazocine | 1979 |
Subcellular distribution of (+)-[3H]SKF 10,047 binding sites in rat liver.
Topics: Animals; Binding Sites; Cell Membrane; Cell Nucleus; Endoplasmic Reticulum; In Vitro Techniques; Liver; Male; Mitochondria, Liver; NADPH-Ferrihemoprotein Reductase; Phenazocine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma | 1992 |
Evidence for distinct phencyclidine and SKF10047 receptors following detergent treatment of rat brain membranes.
Topics: Animals; Brain Chemistry; Cell Membrane; Male; Phenazocine; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Synaptosomes; Tritium | 1992 |
The mu-opioid activity of kappa-opioid receptor agonist compounds in the guinea pig ileum.
Topics: Animals; Ethylketocyclazocine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Nalorphine; Naltrexone; Phenazocine; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1992 |
Enantiomeric N-substituted N-normetazocines: a comparative study of affinities at sigma, PCP, and mu opioid receptors.
Topics: Animals; Brain; Guinea Pigs; Male; Narcotics; Phenazocine; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Opioid, mu; Receptors, Phencyclidine; Receptors, sigma; Stereoisomerism; Substrate Specificity | 1992 |
Biologically active MK-801 and SKF-10,047 binding sites distinct from those in rat brain are expressed on human lung cancer cells.
Topics: Animals; Binding, Competitive; Brain; Dizocilpine Maleate; Humans; Lung Neoplasms; Phenazocine; Radioligand Assay; Rats; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma; Stereoisomerism; Tumor Cells, Cultured | 1992 |
Characterization of [3H]desmethylimipramine binding in bovine adrenal medulla: interactions with sigma- and (or) phencyclidine-receptor ligands.
Topics: Adrenal Medulla; Animals; Binding Sites; Cattle; Desipramine; Dextromethorphan; Dizocilpine Maleate; Phenazocine; Phencyclidine; Piperidines; Potassium Chloride; Receptors, Opioid, delta; Receptors, Phencyclidine; Tranquilizing Agents | 1992 |
Sigma ligand-induced emesis in the pigeon.
Topics: Animals; Apomorphine; Columbidae; Dextromethorphan; Dizocilpine Maleate; Dopamine Agents; Guanidines; Haloperidol; Male; Pentobarbital; Phenazocine; Piperidines; Propranolol; Psychotropic Drugs; Pyrimidines; Receptors, Opioid; Receptors, sigma; Vomiting | 1992 |
Effects of beta-endorphin on spontaneous uterine contractions. Prostaglandins production and 45Ca2+ uptake in uterine strips from ovariectomized rats.
Topics: Animals; beta-Endorphin; Calcium; Dynorphins; Enkephalin, Methionine; Female; In Vitro Techniques; Ion Transport; Ovariectomy; Phenazocine; Prostaglandins; Rats; Rats, Wistar; Uterine Contraction; Uterus | 1992 |
DuP 734 [1-(cyclopropylmethyl)-4-(2'(4''-fluorophenyl)-2'-oxoethyl)- piperidine HBr], a sigma and 5-hydroxytryptamine2 receptor antagonist: receptor-binding, electrophysiological and neuropharmacological profiles.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Biogenic Amines; Guinea Pigs; Male; Phenazocine; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Serotonin; Receptors, sigma; Rotation; Serotonin Antagonists | 1992 |
[3H]DuP 734 [1-(cyclopropylmethyl)-4-(2'-(4''-fluorophenyl)-2'- oxoethyl)-piperidine HBr]: a receptor binding profile of a high-affinity novel sigma receptor ligand in guinea pig brain.
Topics: Animals; Antipsychotic Agents; Brain; Guanylyl Imidodiphosphate; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Male; Mice; Phenazocine; Phenytoin; Piperidines; Receptors, sigma; Structure-Activity Relationship; Temperature | 1992 |
Identification of a novel N-methyl-D-aspartate receptor population in the rat medial thalamus.
Topics: Animals; Autoradiography; Cerebellum; Dizocilpine Maleate; Glutamates; Phenazocine; Piperazines; Prosencephalon; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Thalamus | 1992 |
Interaction of sigma and PCP-like drugs on operant behaviors in the rat.
Topics: Animals; Conditioning, Operant; Dextroamphetamine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Male; Pentazocine; Phenazocine; Phencyclidine; Psychotropic Drugs; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, sigma; Reinforcement Schedule | 1992 |
Tris inhibits (+)-[3H]SKF-10,047 binding to sigma receptors.
Topics: Animals; Dizocilpine Maleate; Haloperidol; Liver; Male; Phenazocine; Rats; Rats, Sprague-Dawley; Receptors, sigma; Stereoisomerism; Tritium; Tromethamine | 1992 |
Involvement of haloperidol-sensitive sigma-sites in antitussive effects.
Topics: Animals; Antitussive Agents; Capsaicin; Cough; Dose-Response Relationship, Drug; Drug Interactions; Guanidines; Haloperidol; Injections, Intraperitoneal; Male; Phenazocine; Rats; Rats, Sprague-Dawley; Receptors, sigma; Stereoisomerism | 1992 |
Effect of haloperidol and clozapine on (+)SKF 10,047-induced dopamine release: role of 5-HT3 receptors.
Topics: Animals; Brain; Clozapine; Corpus Striatum; Dopamine; Haloperidol; Male; Nucleus Accumbens; Phenazocine; Rats; Rats, Inbred Strains; Receptors, Serotonin | 1992 |
Neuroprotective mechanism of (+)SKF 10,047 in vitro and in gerbil global brain ischemia.
Topics: Animals; Brain; Brain Ischemia; Calcium; Cell Count; Cells, Cultured; Cerebellum; Gerbillinae; Granulocytes; Hippocampus; Neurons; Phenazocine; Rats; Rats, Inbred Strains | 1992 |
Neuroprotective effects of SKF 10,047 in cultured rat cerebellar neurons and in gerbil global brain ischemia.
Topics: Animals; Body Temperature; Brain Ischemia; Cells, Cultured; Cerebellum; Cyclazocine; Dizocilpine Maleate; Gerbillinae; Pentazocine; Phenazocine; Rats; Rats, Inbred Strains; Reference Values; Stereoisomerism | 1992 |
Increase of extracellular acetylcholine level in rat frontal cortex induced by (+)N-allylnormetazocine as measured by brain microdialysis.
Topics: 3,4-Dihydroxyphenylacetic Acid; Acetylcholine; Animals; Brain Chemistry; Dialysis; Extracellular Space; Frontal Lobe; Male; Phenazocine; Rats; Rats, Inbred Strains | 1992 |
Neuropeptide Y and peptide YY do not bind to brain sigma and phencyclidine binding sites.
Topics: Animals; Brain; Dizocilpine Maleate; Guinea Pigs; In Vitro Techniques; Neuropeptide Y; Peptide YY; Peptides; Phenazocine; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma; Temperature | 1991 |
Chronic treatment with pentazocine or SFK 10047 decrease proenkephalin mRNA levels in the rat striatum and nucleus accumbens.
Topics: Animals; Base Sequence; Corpus Striatum; Enkephalins; Histocytochemistry; Male; Molecular Sequence Data; Nucleic Acid Hybridization; Nucleus Accumbens; Pentazocine; Phenazocine; Protein Precursors; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma; RNA, Messenger | 1991 |
Psychomotor activity and cognitive disruption attributable to NMDA, but not sigma, interactions in primates.
Topics: Animals; Ataxia; Cognition; Dizocilpine Maleate; Macaca mulatta; Male; Pentazocine; Phenazocine; Phencyclidine; Psychomotor Performance; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Receptors, sigma; Saimiri; Space Perception | 1991 |
Heterogeneous binding of sigma radioligands in the rat brain and liver: possible relationship to subforms of cytochrome P-450.
Topics: Animals; Brain; Cytochrome P-450 Enzyme System; Guanidines; Haloperidol; Kinetics; Ligands; Liver; Male; Phenazocine; Piperazines; Piperidines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma; Subcellular Fractions | 1991 |
Opioid receptor subtype involvement in maternal behavior in lactating rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; beta-Endorphin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Lactation; Maternal Behavior; Morphine; Phenazocine; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu | 1991 |
[Evaluation of the discriminative stimulus effect of an enkephalin analog, EK-399, in the rat].
Topics: Animals; Discrimination, Psychological; Enkephalins; Ethylketocyclazocine; Male; Morphine; Naloxone; Phenazocine; Rats; Rats, Inbred Strains; Receptors, Opioid | 1991 |
Effects of drugs that bind to PCP and sigma receptors on punished responding.
Topics: Animals; Buspirone; Dizocilpine Maleate; Haloperidol; Learning; Male; Pentobarbital; Phenazocine; Phencyclidine; Punishment; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma | 1991 |
Quantitative characterization of multiple binding sites for phencyclidine and N-allylnormetazocine in membranes from rat and guinea pig brain.
Topics: Animals; Binding Sites; Brain; Cell Membrane; Guinea Pigs; Male; Phenazocine; Phencyclidine; Psychotropic Drugs; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma | 1991 |
Interaction of 1,3-di(2-[5-3H]tolyl) guanidine with sigma 2 binding sites in rat heart membrane preparations.
Topics: Animals; Guanidines; Heart; In Vitro Techniques; Kinetics; Ligands; Male; Membranes; Myocardium; Phenazocine; Rats; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma | 1991 |
[3H]DTG and [3H](+)-3-PPP label pharmacologically distinct sigma binding sites in guinea pig brain membranes.
Topics: Animals; Binding, Competitive; Brain; Dextromethorphan; Dopamine Agents; Guanidines; Guinea Pigs; Haloperidol; In Vitro Techniques; Kinetics; Membranes; Phenazocine; Phenytoin; Piperidines; Receptors, Opioid; Receptors, sigma | 1991 |
Evidence for an anti-amnesic effect of JO 1784 in the rat: a potent and selective ligand for the sigma receptor.
Topics: Amnesia; Animals; Antipsychotic Agents; Avoidance Learning; Behavior, Animal; Carbazoles; Cinnamates; Cyclopropanes; Dopamine Agents; Dose-Response Relationship, Drug; Guanidines; Ligands; Male; Phenazocine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma; Scopolamine | 1991 |
Activation of excitatory amino acid receptors cannot alone account for anoxia-induced impairment of protein synthesis in rat hippocampal slices.
Topics: Animals; Aspartic Acid; Carbon Radioisotopes; Dizocilpine Maleate; Glutamates; Glutamic Acid; Hippocampus; Hypoxia; Kainic Acid; Lysine; Male; N-Methylaspartate; Nerve Tissue Proteins; Phenazocine; Phencyclidine; Quisqualic Acid; Rats; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate | 1991 |
Two subtypes of enteric non-opioid sigma receptors in guinea-pig cholinergic motor neurons.
Topics: Animals; Anti-Anxiety Agents; Antipsychotic Agents; Carbazoles; Dextromethorphan; Electric Stimulation; Guanidines; Guinea Pigs; Haloperidol; In Vitro Techniques; Male; Motor Neurons; Myenteric Plexus; Parasympathetic Nervous System; Phenazocine; Pyrimidines; Receptors, Opioid; Receptors, sigma | 1991 |
(+)-6,7-benzomorphan sigma ligands stimulate dopamine synthesis in rat corpus striatum tissue.
Topics: Animals; Benzomorphans; Catecholamines; Corpus Striatum; Cyclazocine; Dopamine; In Vitro Techniques; Ligands; Male; Nerve Endings; Neural Pathways; Pentazocine; Phenazocine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma; Stereoisomerism; Stimulation, Chemical; Tyrosine 3-Monooxygenase | 1991 |
The human sigma site, which resembles that in NCB20 cells, may correspond to a low-affinity site in guinea pig brain.
Topics: Animals; Brain Chemistry; Cells, Cultured; Cerebral Cortex; Cricetinae; Cricetulus; Dopamine Agents; Guanidines; Guinea Pigs; Humans; Kinetics; Male; Mice; Neuroblastoma; Pentazocine; Phenazocine; Piperidines; Radioligand Assay; Receptors, Opioid; Receptors, sigma; Stereoisomerism; Tumor Cells, Cultured | 1991 |
Behavioural and electoencephalographic interactions between haloperidol and PCP/sigma ligands in the rat.
Topics: 2-Amino-5-phosphonovalerate; Analysis of Variance; Animals; Antipsychotic Agents; Behavior, Animal; Catalepsy; Electroencephalography; Haloperidol; Isoquinolines; Kinetics; Male; Phenazocine; Phencyclidine; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Receptors, sigma; Spiperone | 1991 |
Similar behavioural effects of sigma agonists and PCP-like non-competitive NMDA antagonists in guinea-pigs.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Benzamides; Dizocilpine Maleate; Dopamine Agents; Dopamine Antagonists; Ergolines; Female; Guanidines; Guinea Pigs; Haloperidol; Ketamine; Male; Motor Activity; N-Methylaspartate; Pentazocine; Phenazocine; Phencyclidine; Quinpirole; Receptors, Dopamine D2; Receptors, Opioid; Receptors, sigma; Remoxipride | 1991 |
(+) 3-[3-hydroxyphenyl-N-(1-propyl) piperidine] selectively differentiates effects of sigma ligands on neurochemical pathways modulated by sigma receptors: evidence for subtypes, in vivo.
Topics: Adrenocorticotropic Hormone; Animals; Brain; Butaclamol; Cerebellum; Corpus Striatum; Cyclic GMP; Dopamine; Dopamine Agents; Male; Mice; Pentazocine; Phenazocine; Piperidines; Prolactin; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Receptors, sigma | 1991 |
Interactions of sigma and phencyclidine receptor ligands with the norepinephrine uptake carrier in both rat brain and rat tail artery.
Topics: Animals; Biological Transport; Brain; Desipramine; Dizocilpine Maleate; Male; Norepinephrine; Phenazocine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma; Tail; Vasoconstriction | 1991 |
Binding of sigma-ligands to C57BL/6 mouse brain membranes: effects of monoamine oxidase inhibitors and subcellular distribution studies suggest the existence of sigma-receptor subtypes.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Binding Sites; Brain; Guanidines; In Vitro Techniques; Ligands; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Phenazocine; Piperidines; Receptors, Opioid; Receptors, sigma | 1991 |
Electrophysiological and binding studies on intact NCB-20 cells suggest presence of a low affinity sigma receptor.
Topics: Animals; Cricetinae; Cricetulus; Hybrid Cells; Ligands; Mice; Neuroblastoma; Phenazocine; Piperidines; Potassium Channels; Receptors, Opioid; Receptors, sigma; Stereoisomerism; Tumor Cells, Cultured | 1991 |
Solubilization and characterization of haloperidol-sensitive (+)-[3H]SKF-10,047 binding sites (sigma sites) from rat liver membranes.
Topics: Animals; Binding Sites; Cell Membrane; Cholic Acids; Culture Techniques; Haloperidol; Liver; Male; Phenazocine; Rats; Rats, Inbred F344; Receptors, Opioid; Receptors, sigma; Tritium | 1991 |
Stereospecificity of mixed-action opioid agonist/antagonists in morphine-tolerant squirrel monkeys.
Topics: Animals; Cyclazocine; Dose-Response Relationship, Drug; Drug Tolerance; Morphine; Narcotic Antagonists; Narcotics; Pentazocine; Phenazocine; Saimiri; Stereoisomerism | 1990 |
Sigma receptors modulate both A9 and A10 dopaminergic neurons in the rat brain: functional interaction with NMDA receptors.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Cerebral Ventricles; Dopamine; Kinetics; Male; Neurons; Pentazocine; Phenazocine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Receptors, sigma | 1990 |
The sigma [corrected] ligand rimcazole antagonises (+)SKF 10,047, but not (+)3-PPP, in the mouse isolated vas deferens.
Topics: Animals; Antipsychotic Agents; Carbazoles; In Vitro Techniques; Male; Mice; Mice, Inbred DBA; Muscle, Smooth; Phenazocine; Piperidines; Stereoisomerism; Vas Deferens | 1990 |
JO 1784, a potent and selective ligand for rat and mouse brain sigma-sites.
Topics: Animals; Brain Chemistry; Cinnamates; Cyclopropanes; In Vitro Techniques; Male; Mice; Phenazocine; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta | 1990 |
A comparison of the psychopharmacological profiles of phencyclidine, ketamine and (+) SKF 10,047 in the trimethyltin rat model.
Topics: Animals; Avoidance Learning; Behavior, Animal; Brain Chemistry; Ketamine; Learning; Male; Nervous System Diseases; Neurotransmitter Agents; Phenazocine; Phencyclidine; Rats; Receptors, Neurotransmitter; Receptors, Phencyclidine; Swimming; Trimethyltin Compounds | 1990 |
Excitatory amino acid neurotoxicity at the N-methyl-D-aspartate receptor in cultured neurons: protection by SKF 10,047.
Topics: Animals; Cell Survival; Cells, Cultured; Cerebellum; Dopamine Agents; Glutamates; Glutamic Acid; Neurons; Neurotoxins; Phenazocine; Phencyclidine; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine | 1990 |
The lack of utility of the rat vas deferens as a functional bioassay for sigma ligands.
Topics: Animals; Binding Sites; Biological Assay; Electric Stimulation; Guanidines; Guinea Pigs; Haloperidol; Male; Muscle Contraction; Pentazocine; Phenazocine; Phencyclidine; Rats; Rats, Inbred Strains; Vas Deferens | 1991 |
Kappa opioid partial agonist activity of the enkephalin-like pentapeptide BW942C based on urination and in vitro studies in humans and animals.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adult; Amino Acid Sequence; Animals; Diuresis; Dose-Response Relationship, Drug; Drug Tolerance; Enkephalin, Methionine; Enkephalins; Humans; In Vitro Techniques; Male; Molecular Sequence Data; Morphine; Naltrexone; Oligopeptides; Phenazocine; Pyrrolidines; Rabbits; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Urination; Vas Deferens | 1990 |
Guinea pig vas deferens contains sigma but not phencyclidine receptors.
Topics: Animals; Binding, Competitive; Guinea Pigs; Male; Phenazocine; Phencyclidine; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma; Vas Deferens | 1990 |
Characterization of [3H] (+)-pentazocine, a highly selective sigma ligand.
Topics: Animals; Binding, Competitive; Brain; Guinea Pigs; In Vitro Techniques; Kinetics; Pentazocine; Phenazocine; Piperidines; Receptors, Opioid; Receptors, sigma | 1990 |
Sigma receptors modulate the hypothalamic-pituitary-adrenal (HPA) axis centrally: evidence for a functional interaction with NMDA receptors, in vivo.
Topics: Adrenocorticotropic Hormone; Animals; Aspartic Acid; Cells, Cultured; Hypothalamo-Hypophyseal System; Male; N-Methylaspartate; Pentazocine; Phenazocine; Piperazines; Pituitary-Adrenal System; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, sigma | 1990 |
Multiple vascular effects of sigma and PCP ligands: inhibition of amine uptake and contractile responses.
Topics: Animals; Cocaine; Desoxycorticosterone; Haloperidol; Male; Norepinephrine; Phenazocine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma; Serotonin; Vasoconstriction | 1990 |
Evidence against an involvement of the haloperidol-sensitive sigma recognition site in the discriminative stimulus properties of (+)-N-allylnormetazocine ((+)-SKF 10,047).
Topics: Animals; Aspartic Acid; Binding, Competitive; Dibenzocycloheptenes; Discrimination, Psychological; Dizocilpine Maleate; Guanidines; Haloperidol; Male; Mice; N-Methylaspartate; Phenazocine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Seizures | 1990 |
Effects of acute and chronic administration of (+)-SKF 10,047 on body temperature in the rat: cross-sensitization with phencyclidine.
Topics: Animals; Body Temperature; Body Weight; Dose-Response Relationship, Drug; Drug Interactions; Injections, Subcutaneous; Male; Phenazocine; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma; Stereoisomerism | 1990 |
Differential effects of sigma and phencyclidine receptor ligands on learning.
Topics: Animals; Avoidance Learning; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Ketamine; Ligands; Male; Memory; Pentazocine; Phenazocine; Phencyclidine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Phencyclidine; Retention, Psychology | 1990 |
Haloperidol competitively inhibits the binding of (+)-[3H]SKF-10,047 to sigma sites.
Topics: Animals; Binding, Competitive; Guinea Pigs; Haloperidol; In Vitro Techniques; Kinetics; Male; Phenazocine; Rats; Receptors, Opioid; Receptors, sigma | 1990 |
Haloperidol-sensitive (+)[3H]SKF-10,047 binding sites (sigma sites) exhibit a unique distribution in rat brain subcellular fractions.
Topics: 5'-Nucleotidase; Animals; Brain; Choline O-Acetyltransferase; Haloperidol; In Vitro Techniques; Male; Ouabain; Phenazocine; Rats; Rats, Inbred F344; Receptors, Opioid; Receptors, sigma; Subcellular Fractions; Synaptosomes | 1990 |
Selective stimulation of colonic motor response to a meal by sigma ligands in dogs.
Topics: Animals; Cinnamates; Colon; Cyclopropanes; Dogs; Drug Antagonism; Eating; Gastrointestinal Motility; Guanidines; Injections, Intravenous; Injections, Intraventricular; Phenazocine; Phencyclidine; Receptors, Opioid; Receptors, sigma; Stereoisomerism | 1990 |
Effect of selective sigma ligands on duodenal alkaline secretion in the rat.
Topics: Animals; Atropine; Bicarbonates; Dose-Response Relationship, Drug; Duodenum; Guanidines; Haloperidol; Injections, Intravenous; Intestinal Mucosa; Intestinal Secretions; Male; Naloxone; Phenazocine; Prazosin; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma; Yohimbine | 1990 |
Effects of morphine, ethylketocyclazocine, N-allylnormetazocine and naloxone on locomotor activity in the rabbit.
Topics: Animals; Cyclazocine; Ethylketocyclazocine; Female; Male; Morphine; Motor Activity; Naloxone; Nictitating Membrane; Phenazocine; Rabbits | 1990 |
Inhibition of carbachol-induced inositol phosphate accumulation by phencyclidine, phencyclidine-like ligands and sigma agonists involves blockade of the muscarinic cholinergic receptor: a novel dioxadrol-preferring interaction.
Topics: Animals; Brain; Carbachol; Culture Techniques; Dibenzocycloheptenes; Dioxolanes; Dizocilpine Maleate; Inositol Phosphates; Male; Phenazocine; Phencyclidine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Sigma Factor; Transcription Factors | 1990 |
Inhibition of neuronally induced relaxation of canine lower esophageal sphincter by opioid peptides.
Topics: Animals; Autonomic Nervous System; Cyclazocine; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Dogs; Electric Stimulation; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Esophagogastric Junction; Ethylketocyclazocine; In Vitro Techniques; Muscle Relaxation; Muscle, Smooth; Neurons; Phenazocine | 1990 |
Differential modulation by cations of sigma and phencyclidine binding sites in rat brain.
Topics: Animals; Binding Sites; Brain; Cations; Dose-Response Relationship, Drug; Haloperidol; Ligands; Male; Phenazocine; Phencyclidine; Rats; Rats, Inbred Strains; Sigma Factor; Tritium | 1990 |
In vivo characterization of phencyclidine/sigma agonist-mediated inhibition of nociception.
Topics: Animals; Anticonvulsants; Aspartic Acid; Behavior, Animal; Binding, Competitive; Dibenzocycloheptenes; Dizocilpine Maleate; Male; Mice; N-Methylaspartate; Nociceptors; Phenazocine; Phencyclidine; Receptors, Opioid; Receptors, Opioid, delta; Substance P | 1989 |
Substitution and antagonism in rats trained to discriminate (+)-N-allylnormetazocine from saline.
Topics: Animals; Binding Sites; Butaclamol; Cyclazocine; Discrimination Learning; Ethylketocyclazocine; Haloperidol; Male; Phenazocine; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Phencyclidine | 1989 |
Evidence for a model of activation of central sigma systems.
Topics: Animals; Benzazepines; Benzomorphans; Butaclamol; Carbazoles; Dopamine Antagonists; Haloperidol; Kinetics; Male; Models, Biological; Motor Activity; Naltrexone; Narcotic Antagonists; Phenazocine; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma; Sulpiride | 1989 |
Mechanisms of noncompetitive inhibition of acetylcholine-induced single-channel currents.
Topics: Acetylcholine; Biomechanical Phenomena; Cell Line; Electric Conductivity; Electrophysiology; Ion Channels; Phenazocine; Phencyclidine; Tetracaine; Time Factors | 1989 |
In vivo labelling of the NMDA receptor channel complex by [3H]MK-801.
Topics: Affinity Labels; Animals; Anticonvulsants; Aspartic Acid; Binding Sites; Binding, Competitive; Dibenzocycloheptenes; Dioxolanes; Dizocilpine Maleate; Ion Channels; Male; Mice; N-Methylaspartate; Phenazocine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures | 1988 |
Analgesic effects of phencyclidine-like drugs in rhesus monkeys.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Alfentanil; Analgesia; Analgesics; Anesthetics; Animals; Anticonvulsants; Dextrorphan; Dibenzocycloheptenes; Discrimination, Psychological; Dizocilpine Maleate; Dose-Response Relationship, Drug; Fentanyl; Ketamine; Macaca mulatta; Phenazocine; Phencyclidine; Pyrrolidines | 1989 |
Opioids induce postural asymmetry in spinal rat: the side of the flexed limb depends upon the type of opioid agonist.
Topics: Animals; Benzomorphans; Decerebrate State; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Functional Laterality; Male; Muscles; Naloxone; Narcotics; Phenazocine; Posture; Rats; Rats, Inbred Strains; Receptors, Opioid; Spinal Cord; Time Factors | 1989 |
Differential regulation of sigma and PCP receptors after chronic administration of haloperidol and phencyclidine in mice.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Hallucinogens; Haloperidol; Male; Mice; Mice, Inbred Strains; Phenazocine; Phencyclidine; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma; Time Factors | 1989 |
Evidence for a multi-site model of the rat brain sigma receptor.
Topics: Animals; Brain; In Vitro Techniques; Male; Membranes; Models, Biological; Phenazocine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Synaptosomes; Ultraviolet Rays | 1989 |
Phencyclidine-like effects of tetrahydroisoquinolines and related compounds.
Topics: Animals; Ataxia; Behavior, Animal; Chemical Phenomena; Chemistry; Isoquinolines; Male; Molecular Structure; Phenazocine; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Phencyclidine; Stereotyped Behavior; Structure-Activity Relationship; Tetrahydroisoquinolines | 1989 |
Presence of sigma and phencyclidine (PCP)-like receptors in membrane preparations of bovine adrenal medulla.
Topics: Adrenal Medulla; Animals; Binding, Competitive; Cattle; In Vitro Techniques; Phenazocine; Radioligand Assay; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma; Stereoisomerism | 1989 |
The effects of non-competitive NMDA receptor antagonists on rats exposed to hyperbaric pressure.
Topics: Animals; Binding, Competitive; Dibenzocycloheptenes; Dizocilpine Maleate; Hyperbaric Oxygenation; Ketamine; Male; Myoclonus; Phenazocine; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures; Tremor | 1989 |
The behavioural effects of MK-801: a comparison with antagonists acting non-competitively and competitively at the NMDA receptor.
Topics: Animals; Anticonvulsants; Aspartic Acid; Behavior, Animal; Binding, Competitive; Dibenzocycloheptenes; Discrimination Learning; Dizocilpine Maleate; Dose-Response Relationship, Drug; Ketamine; Male; Motor Activity; N-Methylaspartate; Phenazocine; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures | 1989 |
1,3-Di(2-tolyl)guanidine blocks nicotinic response in guinea pig myenteric neurons.
Topics: Animals; Ganglionic Stimulants; Guanidines; Guinea Pigs; In Vitro Techniques; Male; Membrane Potentials; Myenteric Plexus; Neurons; Phenazocine; Receptors, Opioid; Receptors, sigma | 1989 |
[Sigma receptors of the loach embryo regulate ornithine decarboxylase activity].
Topics: Animals; Cell Aggregation; Cypriniformes; Embryo, Nonmammalian; In Vitro Techniques; Ornithine Decarboxylase; Phenazocine; Polyamines; Receptors, Opioid; Receptors, sigma | 1989 |
Effects of competitive and noncompetitive N-methyl-D-aspartate (NMDA) antagonists in rats trained to discriminate NMDA from saline.
Topics: Amino Acids; Animals; Aspartic Acid; Dibenzocycloheptenes; Discrimination Learning; Dizocilpine Maleate; Dose-Response Relationship, Drug; Male; N-Methylaspartate; Phenazocine; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Tripelennamine interactions with the psychotomimetic sigma agonist N-allylnormetazocine.
Topics: Animals; Autonomic Nervous System; Behavior, Animal; Dogs; Drug Interactions; Female; Hallucinogens; Pain; Phenazocine; Receptors, Opioid; Receptors, sigma; Sensory Thresholds; Tripelennamine | 1989 |
Comparative electroencephalographic and behavioral effects of phencyclidine, (+)-SKF-10,047 and MK-801 in rats.
Topics: Animals; Anticonvulsants; Dibenzocycloheptenes; Dizocilpine Maleate; Electroencephalography; Female; Motor Activity; Phenazocine; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, sigma; Stereotyped Behavior | 1989 |
[Adaptive changes in sigma and phencyclidine receptors during the long-term use of haloperidol and raclopride in rats].
Topics: Adaptation, Physiological; Animals; Apomorphine; Behavior, Animal; Drug Interactions; Haloperidol; Ketamine; Phenazocine; Phencyclidine; Raclopride; Rats; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma; Salicylamides; Time Factors; Tritium | 1989 |
Neuropeptide Y and peptide YY interact with rat brain sigma and PCP binding sites.
Topics: Animals; Brain Chemistry; Haloperidol; In Vitro Techniques; Male; Neuropeptide Y; Pentazocine; Peptide YY; Peptides; Phenazocine; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma | 1989 |
Effects of acute and chronic administration of (+)SKF 10,047 on body temperature in the rat.
Topics: Animals; Body Temperature Regulation; Brain; Dose-Response Relationship, Drug; Male; Phenazocine; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma | 1989 |
Characterization of L-glutamate action on the release of endogenous dopamine from the rat caudate-putamen.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Caudate Nucleus; Dopamine; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; In Vitro Techniques; Magnesium; Male; N-Methylaspartate; Oxadiazoles; Phenazocine; Potassium; Putamen; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Conditioned taste aversions induced by phencyclidine and other antagonists of N-methyl-D-aspartate.
Topics: Adrenergic alpha-Antagonists; Animals; Aspartic Acid; Avoidance Learning; Conditioning, Operant; Male; N-Methylaspartate; Phenazocine; Phencyclidine; Piperidines; Rats; Rats, Inbred Strains; Taste | 1989 |
Regulation of sigma-receptors: high- and low-affinity agonist states, GTP shifts, and up-regulation by rimcazole and 1,3-Di(2-tolyl)guanidine.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Binding, Competitive; Brain; Carbazoles; Cyclazocine; Dopamine; Dopamine Agents; GTP-Binding Proteins; Guanidines; Guanosine Triphosphate; Magnesium; Male; Phenazocine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma | 1989 |
Effects of phencyclidine and other N-methyl-D-aspartate antagonists on the schedule-controlled behavior of rats.
Topics: Animals; Aspartic Acid; Conditioning, Psychological; Dibenzocycloheptenes; Dizocilpine Maleate; Male; N-Methylaspartate; Phenazocine; Phencyclidine; Piperazines; Piperidines; Punishment; Rats; Rats, Inbred Strains; Reinforcement Schedule; Stereoisomerism | 1989 |
Cardiovascular and respiratory effects of an opioid kappa agonist ethylketazocine and sigma agonist N-allylnormetazocine in acutely decerebrated dogs.
Topics: Animals; Blood Pressure; Cyclazocine; Decerebrate State; Dogs; Ethylketocyclazocine; Female; Heart Rate; Male; Phenazocine; Pulmonary Ventilation | 1989 |
Interaction of the discriminative stimulus effects of phencyclidine with those of (+)-N-allylnormetazocine, pentobarbital and d-amphetamine.
Topics: Amphetamines; Animals; Columbidae; Discrimination Learning; Drug Interactions; Pentobarbital; Phenazocine; Phencyclidine; Substance-Related Disorders | 1989 |
Effects of mu, kappa and sigma opioids on fixed consecutive number responding in rats.
Topics: Animals; Buprenorphine; Conditioning, Operant; Cyclazocine; Dextroamphetamine; Dose-Response Relationship, Drug; Ethylketocyclazocine; Male; Morphine; Phenazocine; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, sigma | 1987 |
Discriminative stimulus properties of a sigma receptor agonist in the rat: role of monoamine systems.
Topics: Animals; Apomorphine; Biogenic Amines; Brain Chemistry; Discrimination, Psychological; Haloperidol; Male; Methysergide; Phenazocine; Rats; Rats, Inbred F344; Receptors, Opioid; Receptors, Opioid, delta; Yohimbine | 1987 |
A role for receptors of N-methyl-D-aspartic acid in the discriminative stimulus properties of phencyclidine.
Topics: Animals; Discrimination, Psychological; Generalization, Stimulus; Haloperidol; Male; Phenazocine; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1987 |
Receptors and secretory actions of sigma/phencyclidine agonists in anterior pituitary cells.
Topics: Animals; Cell Membrane; Cells, Cultured; Etorphine; Female; Kinetics; Luteinizing Hormone; Phenazocine; Phencyclidine; Pituitary Gland, Anterior; Potassium; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma; Thermodynamics | 1987 |
[3H]MK-801 labels a site on the N-methyl-D-aspartate receptor channel complex in rat brain membranes.
Topics: Animals; Anticonvulsants; Brain; Cations, Divalent; Cell Membrane; Cerebral Cortex; Dibenzocycloheptenes; Dizocilpine Maleate; Kinetics; Male; Phenazocine; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Tissue Distribution; Tritium | 1988 |
Quantitative conformational analyses predict distinct receptor sites for PCP-like and sigma drugs.
Topics: Animals; Binding Sites; Brain; Computer Graphics; Dibenzocycloheptenes; Dizocilpine Maleate; In Vitro Techniques; Isoquinolines; Male; Molecular Conformation; Phenazocine; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma | 1987 |
Steroid binding at sigma receptors suggests a link between endocrine, nervous, and immune systems.
Topics: Animals; Brain; Endocrine Glands; Guinea Pigs; Haloperidol; Immunity; Male; Nervous System Physiological Phenomena; Phenazocine; Receptors, Opioid; Receptors, sigma; Spleen; Steroids | 1988 |
Regulation of the binding of sigma- and phencyclidine (PCP)-receptor ligands in rat brain membranes by guanine nucleotides and ions.
Topics: Animals; Binding, Competitive; Brain; Cations; Guanine Nucleotides; Male; Phenazocine; Phencyclidine; Piperidines; Rats; Receptors, Neurotransmitter; Receptors, Phencyclidine; Subcellular Fractions | 1988 |
Evidence for a non-opioid sigma binding site in the guinea-pig myenteric plexus.
Topics: Animals; Binding, Competitive; Cell Membrane; Chlorpromazine; Cyclazocine; Ethylketocyclazocine; Guinea Pigs; Haloperidol; Imipramine; Male; Myenteric Plexus; Phenazocine; Propranolol; Receptors, Opioid; Receptors, sigma | 1988 |
A role played by sigma receptors in the conditioned suppression of motility in mice.
Topics: Animals; Conditioning, Psychological; Cyclazocine; Drug Tolerance; Male; Mice; Mice, Inbred Strains; Motor Activity; Naloxone; Phenazocine; Receptors, Opioid; Receptors, sigma; Synaptic Membranes | 1988 |
[Partial purification of endogenous inhibitors of (+)-[3H] SKF 10047 binding with sigma-opioid receptors of the liver].
Topics: Acetone; Animals; Chromatography, Gel; Ligands; Liver; Phenazocine; Radioligand Assay; Receptors, Opioid; Receptors, sigma; Swine | 1988 |
Inhibition of (+)[3H]SKF 10,047 binding to rat brain membranes by FAB fragments from a monoclonal antibody directed against the opioid receptor.
Topics: Animals; Antibodies, Monoclonal; Binding Sites; Brain; Immunoglobulin Fragments; Kinetics; Male; Phenazocine; Rats; Rats, Inbred Strains; Receptors, Opioid; Subcellular Fractions | 1988 |
Characterization of opioid, sigma, and phencyclidine receptors in the neuroblastoma-brain hybrid cell line NCB-20.
Topics: Animals; Brain Chemistry; Cell Line; Cricetinae; Hybrid Cells; Kinetics; Mice; Neuroblastoma; Phenazocine; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma | 1988 |
An endogenous ligand for the sigma opioid binding site.
Topics: Animals; Brain; Endorphins; Kinetics; Ligands; Phenazocine; Phencyclidine; Receptors, Opioid; Receptors, sigma; Swine | 1987 |
Biochemical, behavioral, and electrophysiologic actions of the selective sigma receptor ligand (+)-pentazocine.
Topics: Animals; Avoidance Learning; Brain; Discrimination Learning; Evoked Potentials, Visual; Male; Membranes; Pentazocine; Phenazocine; Phencyclidine; Rabbits; Rats; Rats, Inbred F344; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma; Reference Values | 1988 |
Analeptic effect of opiate receptor agonists in rabbits.
Topics: Animals; Arousal; Brain; Central Nervous System Stimulants; Codeine; Cyclazocine; Dose-Response Relationship, Drug; Enkephalin, Methionine; Ethylketocyclazocine; Etorphine; Male; Meperidine; Methadone; Morphine; Naltrexone; Narcotics; Phenazocine; Rabbits; Receptors, Opioid; Reflex | 1985 |
A comparison of the binding of sigma opioids and phencyclidine, and the interaction with antipsychotic drugs in rat brain membranes.
Topics: Animals; Antipsychotic Agents; Binding, Competitive; Brain; Corpus Striatum; Endorphins; Haloperidol; In Vitro Techniques; Male; Membranes; Phenazocine; Phencyclidine; Rats; Receptors, Opioid; Receptors, Opioid, delta | 1986 |
Effects of N-allylnormetazocine (SKF 10,047), phencyclidine, and other psychomotor stimulants in the rat following 6-hydroxydopamine lesion of the ventral tegmental area.
Topics: Amphetamine; Animals; Apomorphine; Caffeine; Central Nervous System Stimulants; Dopamine; Hydroxydopamines; Male; Motor Activity; Oxidopamine; Phenazocine; Phencyclidine; Rats; Rats, Inbred Strains; Scopolamine; Tegmentum Mesencephali | 1986 |
Evidence that the potential antipsychotic agent rimcazole (BW 234U) is a specific, competitive antagonist of sigma sites in brain.
Topics: Animals; Antipsychotic Agents; Apomorphine; Binding, Competitive; Brain; Carbazoles; Clozapine; Guinea Pigs; Kinetics; Male; Methylphenidate; Mice; Phenazocine; Phencyclidine; Phenoxybenzamine; Propranolol; Receptors, Opioid; Receptors, sigma; Sulpiride | 1986 |
Actions of opioids on primate spinothalamic tract neurons.
Topics: Animals; Dynorphins; Enkephalin, Methionine; Macaca fascicularis; Morphine; Naloxone; Narcotics; Neurons; Phenazocine; Phencyclidine; Spinal Cord; Thalamus | 1986 |
HR 375: a potential antipsychotic drug that interacts with dopamine D2 receptors and sigma-receptors in the brain.
Topics: Animals; Antipsychotic Agents; Binding, Competitive; Brain; Guinea Pigs; Isoquinolines; Phenazocine; Piperazines; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Opioid; Receptors, sigma; Spiperone | 1986 |
Involvement of opioid receptors in phencyclidine-induced enhancement of brain histamine turnover in mice.
Topics: Analgesics, Opioid; Animals; Brain; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Haloperidol; Histamine; Histidine Decarboxylase; Ketamine; Male; Methylhistidines; Mice; Naloxone; Pargyline; Phenazocine; Phencyclidine; Receptors, Opioid | 1987 |
Interaction of L-glutamate and magnesium with phencyclidine recognition sites in rat brain: evidence for multiple affinity states of the phencyclidine/N-methyl-D-aspartate receptor complex.
Topics: Animals; Brain; Glutamates; Glutamic Acid; In Vitro Techniques; Kinetics; Magnesium; Male; Phenazocine; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine | 1987 |
Pharmacological specificity of some psychotomimetic and antipsychotic agents for the sigma and PCP binding sites.
Topics: Animals; Antipsychotic Agents; Binding, Competitive; Haloperidol; In Vitro Techniques; Male; Phenazocine; Phencyclidine; Piperidines; Psychotropic Drugs; Rats; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma | 1988 |
Different effects of ethylketocyclazocine on phencyclidine- and N-allylnormetazocine-induced stereotyped behaviors in rats.
Topics: Analgesics, Opioid; Animals; Cyclazocine; Ethylketocyclazocine; Male; Phenazocine; Phencyclidine; Rats; Rats, Inbred Strains; Stereotyped Behavior | 1987 |
Sites of action of mu-, kappa- and sigma-opiate receptor agonists at the feline ileocecal sphincter.
Topics: Animals; Atropine; Cats; Dynorphins; Ganglionic Blockers; Ileocecal Valve; Morphine; Naloxone; Phenazocine; Receptors, Opioid; Tachyphylaxis; Tetrodotoxin; Vagotomy | 1988 |
Correlation of inhibitory potencies of putative antagonists for sigma receptors in brain and spleen.
Topics: Animals; Antipsychotic Agents; Brain Chemistry; Carbazoles; Guinea Pigs; Haloperidol; In Vitro Techniques; Isoquinolines; Male; Phenazocine; Piperazines; Pyrimidines; Receptors, Opioid; Receptors, sigma; Spleen; Tritium | 1988 |
Activation of the A10 mesolimbic system by the sigma-receptor agonist (+)SKF 10,047 can be blocked by rimcazole, a novel putative antipsychotic.
Topics: Animals; Antipsychotic Agents; Carbazoles; Dose-Response Relationship, Drug; Limbic System; Male; Motor Activity; Phenazocine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Opioid; Receptors, sigma | 1988 |
Is the discriminative stimulus produced by phencyclidine due to an interaction with N-methyl-D-aspartate receptors?
Topics: Adrenergic beta-Antagonists; Animals; Anticonvulsants; Chlordiazepoxide; Dibenzocycloheptenes; Discrimination, Psychological; Dizocilpine Maleate; Drug Interactions; Generalization, Stimulus; Male; Phenazocine; Phencyclidine; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1988 |
Body temperature effects of opioids in rats: intracerebroventricular administration.
Topics: Animals; beta-Endorphin; Body Temperature; Cyclazocine; Dose-Response Relationship, Drug; Endorphins; Ethylketocyclazocine; Etorphine; Heroin; Injections, Intraventricular; Injections, Subcutaneous; Male; Morphine; Naloxone; Narcotics; Pentazocine; Phenazocine; Rats; Rats, Inbred Strains | 1986 |
Guanine nucleotide regulation of [125I]beta-endorphin binding to rat brain membranes: monovalent cation requirement.
Topics: Animals; beta-Endorphin; Brain; Cations, Monovalent; Cell Membrane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guanine Nucleotides; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Lithium; Male; Phenazocine; Potassium; Rats; Rats, Inbred Strains; Sodium; Sodium Chloride | 1988 |
Identification of multiple opiate receptors through neuroendocrine responses. I. Effects of agonists.
Topics: Animals; Corticosterone; Cyclazocine; Ethylketocyclazocine; Growth Hormone; Injections, Subcutaneous; Luteinizing Hormone; Male; Morphine; Phenazocine; Pituitary Hormones, Anterior; Prolactin; Rats; Rats, Inbred Strains; Receptors, Opioid | 1985 |
Identification of multiple opiate receptors through neuroendocrine responses. II. Antagonism of mu, kappa and sigma agonists by naloxone and WIN 44,441-3.
Topics: Animals; Azocines; Corticosterone; Cyclazocine; Drug Interactions; Ethylketocyclazocine; Growth Hormone; Luteinizing Hormone; Male; Morphine; Naloxone; Narcotic Antagonists; Phenazocine; Pituitary Hormones, Anterior; Prolactin; Rats; Rats, Inbred Strains; Receptors, Opioid | 1985 |
Differentiating opioids by their pupillary effects in the rat.
Topics: Animals; Cyclazocine; Dose-Response Relationship, Drug; Ethylketocyclazocine; Male; Methadone; Motor Activity; Naloxone; Narcotics; Nystagmus, Physiologic; Phenazocine; Pupil; Rats; Rats, Inbred Strains; Receptors, Opioid; Stereoisomerism | 1985 |
Demonstration of non-opioid sigma binding with (d)3H-SKF 10047 in guinea pig brain.
Topics: Animals; Binding Sites; Brain; Brain Chemistry; Guinea Pigs; Haloperidol; In Vitro Techniques; Male; Phenazocine; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma; Stereoisomerism; Tritium | 1985 |
Sigma opioid receptors; SKF-10,047 update.
Topics: Animals; Electroencephalography; Female; Hallucinogens; Morphine; Naloxone; Phenazocine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma; Stereoisomerism | 1985 |
Sigma opioid receptor: characterization and co-identity with the phencyclidine receptor.
Topics: Animals; Cerebral Cortex; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Phenazocine; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma; Tritium | 1985 |
Plasma corticosterone changes in response to central or peripheral administration of kappa and sigma opiate agonists.
Topics: Animals; Brain; Corticosterone; Cyclazocine; Ethylketocyclazocine; Humans; Hypothalamo-Hypophyseal System; Male; Morphine; Naloxone; Naltrexone; Opioid-Related Disorders; Phenazocine; Pituitary-Adrenal System; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, sigma | 1985 |
Phencyclidine and sigma opiate receptors in brain: biochemical and autoradiographical differentiation.
Topics: Autoradiography; Brain; Humans; In Vitro Techniques; Membranes; Phenazocine; Phencyclidine; Piperidines; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Phencyclidine | 1985 |
Differentiation of [3H]phencyclidine and (+)-[3H]SKF-10,047 binding sites in rat cerebral cortex.
Topics: Animals; Binding Sites; Binding, Competitive; Cerebral Cortex; Male; Phenazocine; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Phencyclidine; Stereoisomerism | 1985 |
Multiple opiate receptors may be involved in suppressing gamma-aminobutyrate release in substantia nigra.
Topics: Aminooxyacetic Acid; Animals; Benzomorphans; Dopamine; Enkephalin, Methionine; Female; gamma-Aminobutyric Acid; Male; Naloxone; Nialamide; Phenazocine; Rats; Rats, Inbred Strains; Receptors, Opioid; Secretory Rate; Substantia Nigra | 1985 |
[Specific binding of N-allylnormetazocine (SKF 10047), a ligand of sigma-opioid receptors, with liver membranes].
Topics: Animals; Brain; Guinea Pigs; Humans; In Vitro Techniques; Kinetics; Ligands; Liver; Male; Membranes; Mice; Mice, Inbred BALB C; Phenazocine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma; Species Specificity | 1985 |
Evidence for multiple opiate receptor involvement in different phencyclidine-induced unconditioned behaviors in rats.
Topics: Animals; Behavior, Animal; Conditioning, Operant; Dose-Response Relationship, Drug; Drinking; Drug Interactions; Eating; Habituation, Psychophysiologic; Male; Morphine; Motor Activity; Naloxone; Phenazocine; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Opioid; Stereotyped Behavior | 1986 |
Interaction of [3H](-)-SKF-10,047 with brain sigma receptors: characterization and autoradiographic visualization.
Topics: Animals; Autoradiography; Binding, Competitive; Brain; Cell Membrane; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Morphine Derivatives; Narcotics; Phenazocine; Rats; Rats, Inbred Strains; Receptors, Opioid; Tissue Distribution | 1986 |
Metaphit, a proposed phencyclidine receptor acylator: phencyclidine-like behavioral effects and evidence of absence of antagonist activity in pigeons and in rhesus monkeys.
Topics: Acylation; Animals; Ataxia; Catalepsy; Columbidae; Discrimination Learning; Drug Synergism; Ketamine; Macaca mulatta; Phenazocine; Phencyclidine; Receptors, Neurotransmitter; Receptors, Phencyclidine; Species Specificity; Stereotyped Behavior | 1986 |
Discriminative stimulus effects of the opioid antagonist diprenorphine in the squirrel monkey.
Topics: Animals; Cyclazocine; Diprenorphine; Discrimination Learning; Dose-Response Relationship, Drug; Ethylketocyclazocine; Generalization, Stimulus; Morphinans; Naloxone; Narcotic Antagonists; Phenazocine; Psychotropic Drugs; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Saimiri | 1986 |
Characterization and autoradiographic visualization of (+)-[3H]SKF10,047 binding in rat and mouse brain: further evidence for phencyclidine/"sigma opiate" receptor commonality.
Topics: Animals; Autoradiography; Brain Chemistry; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Naloxone; Phenazocine; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma; Species Specificity; Tritium | 1986 |
Endogenous ligands for sigma opioid receptors in the brain ("sigmaphin"): evidence from binding assays.
Topics: Animals; Binding, Competitive; Brain; Chromatography, Gel; Cyclazocine; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Kinetics; Male; Naloxone; Phenazocine; Phencyclidine; Radioligand Assay; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, Phencyclidine; Receptors, sigma | 1986 |
Further evidence of phencyclidine/sigma opioid receptor commonality.
Topics: Animals; Autoradiography; Brain; Kinetics; Phenazocine; Phencyclidine; Rats; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma; Tissue Distribution; Tritium | 1986 |
Sigma receptors on NCB-20 hybrid neurotumor cells labeled with (+)[3H]SKF 10,047 and (+)[3H]3-PPP.
Topics: Animals; Brain; Cells, Cultured; Cricetinae; Cricetulus; Hybrid Cells; Kinetics; Neuroblastoma; Phenazocine; Phencyclidine; Piperidines; Receptors, Opioid; Receptors, Opioid, delta; Stereoisomerism | 1986 |
Autoradiographic distribution of phencyclidine receptors in the rat brain using [3H]1-(1-(2-thienyl)cyclohexyl)piperidine ([3H]TCP).
Topics: Animals; Autoradiography; Brain; Male; Phenazocine; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Phencyclidine | 1986 |
Pharmacological and autoradiographic discrimination of sigma and phencyclidine receptor binding sites in brain with (+)-[3H]SKF 10,047, (+)-[3H]-3-[3-hydroxyphenyl]-N-(1-propyl)piperidine and [3H]-1-[1-(2-thienyl)cyclohexyl]piperidine.
Topics: Animals; Autoradiography; Binding, Competitive; Brain Chemistry; In Vitro Techniques; Kinetics; Male; Phenazocine; Phencyclidine; Piperidines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma; Stereoisomerism | 1986 |
Phencyclidine-induced stereotyped behaviors after injection of morphine and N-allylnormetazocine (SKF 10,047) in rats.
Topics: Animals; Male; Morphine; Motor Activity; Phenazocine; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma; Stereotyped Behavior | 1986 |
(+)-3-PPP antagonizes the discriminative stimulus effects of (+)-N-allylnormetazocine.
Topics: Animals; Binding Sites; Conditioning, Operant; Discrimination, Psychological; Generalization, Stimulus; Phenazocine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta | 1986 |
Involvement of opioid receptors in hypo- and hyperthermic effects induced by phencyclidine in mice.
Topics: Animals; Benzomorphans; Body Temperature; Cyclazocine; Ethylketocyclazocine; Hyperthermia, Induced; Hypothermia, Induced; Male; Mice; Morphine; Naloxone; Narcotic Antagonists; Phenazocine; Phencyclidine; Receptors, Opioid | 1986 |
Discriminative stimulus effects of N-allylnormetazocine in rats trained to discriminate a kappa from a sigma agonist.
Topics: Animals; Cyclazocine; Discrimination Learning; Ethylketocyclazocine; Male; Phenazocine; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, sigma; Stereoisomerism | 1987 |
Discriminative stimulus properties of (+)-N-allylnormetazocine in the rat: correlations with (+)-N-allylnormetazocine and phencyclidine receptor binding.
Topics: Animals; Brain; Cyclazocine; Discrimination Learning; Ketamine; Male; Pentazocine; Phenazocine; Phencyclidine; Rats; Rats, Inbred F344; Receptors, Neurotransmitter; Receptors, Phencyclidine; Stereoisomerism | 1987 |
The effects of N-allylnormetazocine on electric shock titration in squirrel monkeys.
Topics: Animals; Avoidance Learning; Electroshock; Male; Morphine; Phenazocine; Phencyclidine; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, sigma; Reinforcement Schedule; Saimiri; Stereoisomerism | 1987 |
(+)- and (-)-N-allylnormetazocine binding sites in mouse brain: in vitro and in vivo characterization and regional distribution.
Topics: Animals; Binding, Competitive; Brain; Cyclazocine; Ethylketocyclazocine; Haloperidol; In Vitro Techniques; Mice; Naloxone; Phenazocine; Phencyclidine; Receptors, Opioid; Receptors, sigma; Stereoisomerism | 1987 |
[3H]PCP-3-OH and (+)[3H]SKF 10047 binding sites in rat brain membranes: evidence of multiplicity.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Haloperidol; In Vitro Techniques; Phenazocine; Phencyclidine; Rats; Receptors, Neurotransmitter; Receptors, Phencyclidine | 1987 |
Differential tolerance to repeated daily injections of N-allylnormetazocine and its enantiomers in the rat.
Topics: Animals; Behavior, Animal; Brain; Drug Tolerance; Electroencephalography; Female; Hallucinogens; Male; Phenazocine; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid; Sleep; Stereoisomerism | 1987 |
Effects of phencyclidine, SKF 10,047 and related psychotomimetic agents on N-methyl-D-aspartate receptor mediated synaptic responses in rat hippocampal slices.
Topics: Analgesics; Animals; Dioxolanes; Hallucinogens; Hippocampus; In Vitro Techniques; Ketamine; Kinetics; Magnesium; Neuromuscular Depolarizing Agents; Phenazocine; Phencyclidine; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses; Synaptic Transmission | 1987 |
Comparison of the pharmacologic effects of N-allylnormetazocine and phencyclidine: sensitization, cross-sensitization, and opioid antagonist activity.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Male; Morphine Dependence; Motor Activity; Narcotic Antagonists; Phenazocine; Phencyclidine; Rats; Rats, Inbred Strains; Stereoisomerism | 1986 |
Oral self-administration of N-allylnormetazocine (SKF-10,047) stereoisomers in rhesus monkeys: substitution during phencyclidine self-administration and withdrawal.
Topics: Administration, Oral; Animals; Macaca mulatta; Male; Phenazocine; Phencyclidine; Self Administration; Stereoisomerism; Substance Withdrawal Syndrome | 1988 |
N-allylnormetazocine: hemodynamic actions and inhibition of leucine-enkephalin hemodynamic activity in conscious dogs.
Topics: Animals; Blood Pressure; Dogs; Enkephalin, Leucine; Female; Heart Rate; Hemodynamics; Male; Naloxone; Phenazocine; Stereoisomerism | 1988 |
Psychotomimetic sigma-ligands, dexoxadrol and phencyclidine block the same presynaptic potassium channel in rat brain.
Topics: Animals; Brain; Cyclazocine; Dioxolanes; Dioxoles; Dose-Response Relationship, Drug; Hallucinogens; In Vitro Techniques; Naloxone; Phenazocine; Phencyclidine; Piperidines; Potassium Channels; Rats; Synaptosomes | 1988 |
[Effect of opioid peptides on the lymphatic drainage of the pancreas in the rat and dog].
Topics: Animals; Dogs; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Evans Blue; Female; Lymph; Male; Naloxone; Pancreas; Phenazocine; Rats; Rats, Inbred Strains | 1988 |
Comparison of the discriminative stimulus properties of U50,488 and morphine in pigeons.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Columbidae; Cyclazocine; Dextroamphetamine; Discrimination Learning; Dose-Response Relationship, Drug; Ethylketocyclazocine; Female; Fentanyl; Methadone; Morphine; Naloxone; Phenazocine; Phencyclidine; Pyrrolidines; Time Factors | 1987 |
(+)-[3H]SK&F 10,047 binding sites in rat liver.
Topics: Animals; Binding Sites; Cations; Enzymes; In Vitro Techniques; Kinetics; Liver; Male; Phenazocine; Rats; Rats, Inbred Strains; Trypsin; Type C Phospholipases | 1988 |
Influence of N-allyl-normetazocine on acetylcholine release from brain slices: involvement of muscarinic receptors.
Topics: Acetylcholine; Animals; Brain; Caudate Nucleus; Cerebral Cortex; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Phenazocine; Rats; Receptors, Muscarinic; Thalamus | 1987 |
The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.
Topics: Animals; Anticonvulsants; Aspartic Acid; Binding Sites; Brain; Dibenzocycloheptenes; Dizocilpine Maleate; In Vitro Techniques; Ketamine; Male; N-Methylaspartate; Phenazocine; Phencyclidine; Rats; Rats, Inbred Strains | 1986 |
Effects of morphine, ethylketocyclazocine, and N-allylnormetazocine on classical conditioning of the rabbit nictitating membrane response.
Topics: Animals; Conditioning, Classical; Conditioning, Eyelid; Cyclazocine; Ethylketocyclazocine; Female; Light; Male; Morphine; Nictitating Membrane; Phenazocine; Rabbits; Sound | 1986 |
Evaluation of the effects of opioid agonists and antagonists under a fixed-consecutive-number schedule in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Conditioning, Operant; Cyclazocine; Discrimination Learning; Ethylketocyclazocine; Male; Methadone; Morphine; Naloxone; Narcotics; Phenazocine; Pyrrolidines; Rats; Reinforcement Schedule | 1987 |
Interaction of a benzomorphan opiate with acetylcholinesterase and the nicotinic acetylcholine receptor.
Topics: Acetylcholinesterase; Animals; Binding Sites; Binding, Competitive; Cell Membrane; Cholinesterase Inhibitors; In Vitro Techniques; Phenazocine; Photochemistry; Receptors, Nicotinic; Torpedo | 1987 |
Use of the radial maze in studies of phencyclidine and other drugs of abuse.
Topics: Animals; Brain; Learning; Lysergic Acid Diethylamide; Memory; Organ Specificity; Phenazocine; Phencyclidine; Scopolamine; Substance-Related Disorders; Verapamil | 1987 |
[Specific binding of (+)-3H-SKF 10047 by mouse splenocytes].
Topics: Animals; In Vitro Techniques; Isomerism; Male; Mice; Mice, Inbred Strains; Phenazocine; Species Specificity; Spleen; Tritium | 1987 |
Effects of sigma agonist compounds on local cerebral glucose utilization: relationship to psychotomimetic properties.
Topics: Animals; Brain; Dioxolanes; Dioxoles; Glucose; Hallucinogens; Male; Phenazocine; Phencyclidine; Piperidines; Rats; Rats, Inbred Strains | 1986 |
Electroencephalographic (EEG), EEG power spectra, and behavioral correlates in rats given phencyclidine.
Topics: Animals; Arousal; Behavior, Animal; Cerebral Cortex; Electroencephalography; Female; Ketamine; Motor Activity; Phenazocine; Phencyclidine; Rats; Rats, Inbred Strains; Stereotyped Behavior | 1986 |
[The opiate sigma-agonist SKF 10.047 disturbs the early morphogenesis of the loach].
Topics: Animals; Cypriniformes; Morphogenesis; Phenazocine | 1986 |
Pharmacologic and reinforcing properties of phencyclidine and the enantiomers of N-allylnormetazocine in the dog.
Topics: Animals; Behavior, Animal; Conditioning, Operant; Decerebrate State; Dogs; Female; Morphine; Naltrexone; Phenazocine; Phencyclidine; Reinforcement Schedule; Self Administration; Stereoisomerism | 1986 |
(+)-3-(3-hydroxyphenyl)-N-(1-propyl)piperidine [(+)-3-PPP] but not (-)-3-PPP produces (+)-N-allylnormetazocine-like (SKF 10,047) discriminative stimuli.
Topics: Animals; Apomorphine; Discrimination Learning; Dose-Response Relationship, Drug; Isomerism; Male; Phenazocine; Phencyclidine; Piperidines; Rats; Rats, Inbred F344 | 1986 |
Demonstration and affinity labeling of a stereoselective binding site for a benzomorphan opiate on acetylcholine receptor-rich membranes from Torpedo electroplaque.
Topics: Affinity Labels; Animals; Binding Sites; Bungarotoxins; Electric Organ; Electrophoresis, Polyacrylamide Gel; Kinetics; Phenazocine; Phencyclidine; Photochemistry; Receptors, Cholinergic; Torpedo | 1985 |
Historical introduction and review of chemistry.
Topics: Analgesics; Chemistry; History, 20th Century; Nalorphine; Naloxone; Naltrexone; Narcotic Antagonists; Phenazocine | 1985 |
Selected opioids and responding for intracranial reinforcement.
Topics: Animals; Cyclazocine; Ethylketocyclazocine; Hypothalamic Area, Lateral; Naloxone; Phenazocine; Rats; Reinforcement, Psychology; Self Stimulation; Stereoisomerism | 1985 |
Mechanism of binding of a benzomorphan opiate to the acetylcholine receptor from Torpedo electroplaque.
Topics: Affinity Labels; Animals; Binding Sites; Bungarotoxins; Carbachol; Decamethonium Compounds; In Vitro Techniques; Kinetics; Phenazocine; Phencyclidine; Receptors, Cholinergic; Structure-Activity Relationship; Tetracaine; Torpedo; Tritium; Tubocurarine | 1986 |
Effects of phencyclidine, N-allyl-N-normetazocine (SKF-10,047), and verapamil on performance in a radial maze.
Topics: Animals; Conditioning, Psychological; Dose-Response Relationship, Drug; Male; Memory; Phenazocine; Phencyclidine; Rats; Rats, Inbred F344; Time Factors; Verapamil | 1986 |
The convulsant and anticonvulsant effects of phencyclidine (PCP) and PCP analogues in the rat.
Topics: Animals; Anticonvulsants; Chemical Phenomena; Chemistry; Convulsants; Dose-Response Relationship, Drug; Female; Ketamine; Phenazocine; Phencyclidine; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1986 |
Characterization of specific binding sites for [3H](d)-N-allylnormetazocine in rat brain membranes.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Cell Membrane; Kinetics; Male; Phenazocine; Rats; Rats, Inbred Strains; Tissue Distribution; Tritium | 1985 |
Stereoselective behavioral effects of N-allylnormetazocine in pigeons and squirrel monkeys.
Topics: Animals; Columbidae; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Interactions; Haloperidol; Male; Morphine; Naloxone; Phenazocine; Phencyclidine; Reinforcement Schedule; Saimiri; Stereoisomerism | 1985 |
Behavioral effects of selected opiates and phencyclidine in the nondependent and cyclazocine-dependent rhesus monkey.
Topics: Animals; Behavior, Animal; Cyclazocine; Dose-Response Relationship, Drug; Drug Tolerance; Ethylketocyclazocine; Food; Macaca mulatta; Male; Naloxone; Phenazocine; Phencyclidine; Stereoisomerism; Substance-Related Disorders | 1985 |
Sigma receptors mediated the psychotomimetic effects of N-allylnormetazocine (SKF-10,047), but not its opioid agonistic-antagonistic properties.
Topics: Animals; Binding, Competitive; Brain; Dihydromorphine; Electroencephalography; Female; Hallucinogens; Humans; Morphine; Morphine Dependence; Phenazocine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma; Stereoisomerism | 1984 |
Comparison of sigma- and kappa-opiate receptor ligands as excitatory amino acid antagonists.
Topics: Acetylcholine; Amino Acids; Animals; Aspartic Acid; Cats; Cyclazocine; Ethylketocyclazocine; Kainic Acid; Ketamine; Ligands; Microelectrodes; N-Methylaspartate; Neurons; Oxadiazoles; Phenazocine; Quisqualic Acid; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, sigma; Stereoisomerism | 1984 |
The effects of phencyclidine and N-allylnormetazocine on midbrain dopamine neuronal activity.
Topics: Animals; Haloperidol; Iontophoresis; Male; Mesencephalon; Phenazocine; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Neurotransmitter; Receptors, Phencyclidine; Stereoisomerism | 1984 |
Stereoisomers of [3H]-N-allylnormetazocine bind to different sites in mouse brain.
Topics: Animals; Binding Sites; Brain; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Narcotics; Phenazocine; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, sigma; Stereoisomerism; Tritium | 1984 |
Differential neuropharmacological effects of mu, kappa and sigma opioid agonists on cortical EEG power spectra in the rat. Stereospecificity and naloxone antagonism.
Topics: Animals; Cerebral Cortex; Cyclazocine; Electroencephalography; Ethylketocyclazocine; Female; Methadone; Molecular Conformation; Morphine; Phenazocine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, sigma | 1984 |
3H-SKF10047 receptor binding studies. Attempts to define the opioid sigma receptor.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Endorphins; Guinea Pigs; Humans; In Vitro Techniques; Narcotics; Phenazocine; Psychomotor Agitation; Receptors, Opioid; Receptors, sigma | 1984 |
Demonstration and distribution of an opiate binding site in rat brain with high affinity for ethylketocyclazocine and SKF 10,047.
Topics: Analgesics, Opioid; Animals; Brain; Cerebral Cortex; Corpus Striatum; Cyclazocine; Ethylketocyclazocine; Kinetics; Mesencephalon; Phenazocine; Rats; Receptors, Opioid; Thalamus; Tissue Distribution | 1981 |
Distinct high-affinity binding sites for benzomorphan drugs and enkephalin in a neuroblastoma--brain hybrid cell line.
Topics: Analgesics, Opioid; Animals; Benzomorphans; Binding Sites; Binding, Competitive; Brain; Cell Line; Cyclazocine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Hybrid Cells; Kinetics; Morphinans; Neuroblastoma; Phenazocine; Rats; Receptors, Opioid | 1981 |
Multiple opiate receptors: emerging concepts.
Topics: Analgesics, Opioid; Animals; Behavior; Binding, Competitive; Brain; Cyclazocine; Ethylketocyclazocine; Kinetics; Phenazocine; Rats; Receptors, Opioid; Structure-Activity Relationship | 1981 |
Discrimination of three opiate receptor binding sites with the use of a computerized curve-fitting technique.
Topics: Animals; Binding, Competitive; Brain; Computers; Cyclazocine; Dihydromorphine; Diprenorphine; Dynorphins; Endorphins; Ethylketocyclazocine; In Vitro Techniques; Kinetics; Phenazocine; Rats; Receptors, Opioid | 1982 |
Comparisons between phencyclidine, its monohydroxylated metabolites, and the stereoisomers of N-allyl-N-normetazocine (SKF 10047) as inhibitors of the muscarinic receptor and acetylcholinesterase.
Topics: Acetylcholinesterase; Animals; Behavior, Animal; Cholinesterase Inhibitors; In Vitro Techniques; Male; Membranes; Parasympatholytics; Phenazocine; Phencyclidine; Quinuclidinyl Benzilate; Rats; Stereoisomerism | 1982 |
In vivo evidence for multiple opiate receptors mediating analgesia in the rat spinal cord.
Topics: Animals; Cyclazocine; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Injections, Spinal; Male; Naloxone; Pain; Phenazocine; Rats; Rats, Inbred Strains; Receptors, Opioid; Spinal Cord | 1982 |
Progress report from the NIDA Addiction Research Center (preclinical laboratory), Lexington, Kentucky.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Cocaine; Dogs; Guinea Pigs; Humans; Kinetics; Male; Nicotine; Opioid-Related Disorders; Oxymorphone; Phenazocine; Phencyclidine; Rats; Self Administration; Stereoisomerism | 1983 |
Effects of elevated calcium and calcium antagonists on 6,7-benzomorphan-induced analgesia.
Topics: Analgesia; Analgesics; Analgesics, Opioid; Animals; Benzomorphans; Calcium; Calcium Channel Blockers; Cyclazocine; Egtazic Acid; Ethylketocyclazocine; Gallopamil; Male; Mice; Morphinans; Pentazocine; Phenazocine | 1983 |
Phencyclidine-induced locomotor activity in the rat is blocked by 6-hydroxydopamine lesion of the nucleus accumbens: comparisons to other psychomotor stimulants.
Topics: Animals; Caffeine; Central Nervous System Stimulants; Dextroamphetamine; Hydroxydopamines; Motor Activity; Nucleus Accumbens; Oxidopamine; Phenazocine; Phencyclidine; Rats; Receptors, Dopamine; Scopolamine; Septal Nuclei | 1984 |
The effect of two different buffers on the high affinity 3H-ethylketocyclazocine and 3H-SKF10047 binding to guinea pig brain membranes.
Topics: Analgesics, Opioid; Animals; Brain; Cyclazocine; Ethylketocyclazocine; Guinea Pigs; HEPES; In Vitro Techniques; Morphine; Naloxone; Phenazocine; Piperazines; Receptors, Opioid; Tritium; Tromethamine | 1984 |
Sigma opiates and certain antipsychotic drugs mutually inhibit (+)-[3H] SKF 10,047 and [3H]haloperidol binding in guinea pig brain membranes.
Topics: Animals; Antipsychotic Agents; Binding, Competitive; Brain; Cell Membrane; Corpus Striatum; Guinea Pigs; Haloperidol; Kinetics; Male; Narcotics; Phenazocine; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Opioid; Receptors, sigma; Spiperone | 1984 |
Feeding systems in Chinese hamsters.
Topics: Animals; Brain; Calcitonin; Circadian Rhythm; Cricetinae; Cyclazocine; Diabetes Mellitus; Dynorphins; Eating; Endorphins; Ethylketocyclazocine; Feeding Behavior; Haloperidol; Mesocricetus; Naloxone; Peptide Fragments; Phenazocine; Sincalide; Starvation | 1984 |
Behavioral and biochemical stereoselectivity of sigma opiate/PCP receptors.
Topics: Animals; Behavior, Animal; Brain; Cyclazocine; Hydromorphone; In Vitro Techniques; Ketamine; Male; Phenazocine; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Opioid; Stereoisomerism | 1984 |
Discriminative stimulus effects of prototype opiate receptor agonists in monkeys.
Topics: Animals; Apomorphine; Cyclazocine; Ethylketocyclazocine; Female; Generalization, Stimulus; Haloperidol; Male; Models, Biological; Morphine; Naltrexone; Phenazocine; Prejudice; Receptors, Opioid; Saimiri | 1980 |
Actions of kappa, sigma and partial mu narcotic receptor agonists on rat brain acetylcholine turnover.
Topics: Acetylcholine; Animals; Brain; Buprenorphine; Male; Morphinans; Naloxone; Organ Specificity; Phenazocine; Rats; Receptors, Opioid | 1981 |
Central injection of a sigma opioid receptor agonist alters body temperature of cats.
Topics: Animals; Body Temperature Regulation; Cats; Dose-Response Relationship, Drug; Pentazocine; Phenazocine; Receptors, Opioid | 1981 |
The binding and analgesic properties of a sigma opiate, SKF 10,047.
Topics: Analgesics; Animals; Binding, Competitive; Brain; In Vitro Techniques; Mice; Mice, Inbred Strains; Narcotic Antagonists; Narcotics; Phenazocine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma | 1981 |
Stereoisomers of N-allylnormetazocine: phencyclidine-like behavioral effects in squirrel monkeys and rats.
Topics: Animals; Behavior, Animal; Male; Naloxone; Phenazocine; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Opioid; Saimiri; Stereoisomerism; Structure-Activity Relationship | 1982 |
Psychotomimetic opioid binding: specific binding of [3H]SKF-10047 to etorphine-inaccessible sites in guinea-pig brain.
Topics: Animals; Binding, Competitive; Brain; Etorphine; Guinea Pigs; Hallucinogens; In Vitro Techniques; Phenazocine; Receptors, Opioid | 1981 |
Interactions between narcotic agonists, partial agonists andd antagonists evaluated by punished an unpunished behavior in the rat.
Topics: Animals; Conditioning, Psychological; Cyclazocine; Dose-Response Relationship, Drug; Ethylketocyclazocine; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Phenazocine; Punishment; Rats; Rats, Inbred Strains; Receptors, Opioid | 1982 |
The binding of kappa- and sigma-opiates in rat brain.
Topics: Animals; Binding Sites; Brain; Culture Techniques; Cyclazocine; Dihydromorphine; Enkephalins; Ethylketocyclazocine; Ligands; Male; Naloxone; Narcotics; Phenazocine; Rats; Rats, Inbred Strains; Receptors, Opioid; Tritium | 1982 |
Opiate and opioid peptide binding in rat goldfish: further evidence for opiate receptor heterogeneity.
Topics: Animals; Brain; Cyclazocine; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Goldfish; Male; Naloxone; Narcotics; Phenazocine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, sigma | 1982 |
Non-opioid psychotomimetic-like discriminative stimulus properties of N-allylnormetazocine (SKF 10,047) in the rat.
Topics: Animals; Discrimination Learning; Discrimination, Psychological; Generalization, Stimulus; Hallucinogens; Male; Phenazocine; Rats; Rats, Inbred Strains; Receptors, Opioid | 1982 |
Evidence for sigma opioid receptor: binding of [3H]SKF-10047 to etorphine-inaccessible sites in guinea-pig brain.
Topics: Animals; Binding, Competitive; Brain; Etorphine; Guinea Pigs; Kinetics; Male; Organ Specificity; Phenazocine; Receptors, Opioid; Receptors, sigma | 1982 |
Opiate receptor-mediated inhibition of catecholamine release in primary cultures of bovine adrenal chromaffin cells.
Topics: Acetylcholine; Adrenal Medulla; Animals; beta-Endorphin; Catecholamines; Cattle; Cells, Cultured; Chromaffin Granules; Chromaffin System; Cyclazocine; Dihydromorphine; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Etorphine; Phenazocine; Receptors, Opioid | 1982 |
Anorexia and hyperphagia produced by five pharmacologic classes of hallucinogens.
Topics: Amphetamine; Animals; Anorexia; Atropine; Dextroamphetamine; Dogs; Dronabinol; Feeding and Eating Disorders; Feeding Behavior; Female; Hallucinogens; Humans; Lysergic Acid Diethylamide; Male; Phenazocine; Phencyclidine | 1982 |
The epileptogenic spectrum of opiate agonists.
Topics: Animals; Anticonvulsants; beta-Endorphin; Cyclazocine; Electroencephalography; Endorphins; Enkephalin, Leucine; Epilepsy; Ethylketocyclazocine; Injections, Intraventricular; Male; Naloxone; Narcotics; Phenazocine; Rats; Rats, Inbred Strains | 1982 |
Effects of the combination of tripelennamine and pentazocine at the behavioral and molecular levels.
Topics: Animals; Brain; Diphenhydramine; Discrimination, Psychological; Drug Synergism; Guinea Pigs; Ileum; Learning; Male; Morphine; Pentazocine; Phenazocine; Rats; Receptors, Opioid; Synaptic Membranes; Tripelennamine | 1982 |
Peptide and non-peptide opioid-induced hyperthermia in rabbits.
Topics: Animals; beta-Endorphin; Body Temperature; Cyclazocine; Endorphins; Enkephalin, Methionine; Enkephalins; Ethylketocyclazocine; Male; Morphine; Naloxone; Peptides; Phenazocine; Rats | 1983 |
Reinforcing properties of stereoisomers of the putative sigma agonists N-allylnormetazocine and cyclazocine in rhesus monkeys.
Topics: Animals; Cocaine; Cyclazocine; Dose-Response Relationship, Drug; Macaca mulatta; Male; Phenazocine; Receptors, Opioid; Receptors, sigma; Reinforcement, Psychology; Self Stimulation; Stereoisomerism; Structure-Activity Relationship | 1983 |
Differential stereospecific effects of mu, kappa, and sigma opioid agonists on cortical EEG power spectra in the rat.
Topics: Animals; Cerebral Cortex; Cyclazocine; Electroencephalography; Ethylketocyclazocine; Female; Methadone; Phenazocine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, sigma; Stereoisomerism | 1983 |
Modulation of phencyclidine receptor sensitivity.
Topics: Amantadine; Animals; In Vitro Techniques; Olfactory Bulb; Phenazocine; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Stereoisomerism | 1983 |
Progress report: Medical College of Virginia--sigma agonists.
Topics: Animals; Binding, Competitive; Discrimination, Psychological; Humans; Isomerism; Kinetics; Phenazocine; Reaction Time; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, sigma; Stereoisomerism | 1983 |
Opiate-induced enhancement of the effects of naloxone on serum luteinizing hormone levels in the male rat: specificity for Mu agonists.
Topics: Animals; Binding, Competitive; Cyclazocine; Ethanol; Ethylketocyclazocine; Kinetics; Luteinizing Hormone; Male; Morphine; Naloxone; Pentobarbital; Phenazocine; Rats; Rats, Inbred Strains; Receptors, Opioid | 1983 |
The binding to rat brain homogenates of Mr2034, a universal opiate.
Topics: Animals; Benzomorphans; Brain; Cyclazocine; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Male; Morphinans; Naloxone; Phenazocine; Rats; Rats, Inbred Strains; Receptors, Opioid | 1983 |
Antinociceptive studies of the optical isomers of N-allylnormetazocine (SKF 10,047).
Topics: Analgesics; Animals; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Phenazocine; Receptors, Adrenergic, alpha; Receptors, Opioid; Stereoisomerism; Yohimbine | 1983 |
Naltrexone fails to antagonize the sigma effects of PCP and SKF 10,047 in the dog.
Topics: Animals; Body Temperature; Dogs; Female; Heart Rate; Morphine; Naloxone; Naltrexone; Paraplegia; Phenazocine; Phencyclidine; Receptors, Opioid; Receptors, sigma; Reflex | 1983 |
An analysis of nicotinic and opioid processes in the medulla oblongata and nucleus ambiguus of the dog.
Topics: Animals; Blood Pressure; Cyclazocine; Decerebrate State; Dogs; Electric Stimulation; Endorphins; Ethylketocyclazocine; Female; Fentanyl; Heart Rate; Male; Mecamylamine; Medulla Oblongata; Naloxone; Nicotine; Phenazocine; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, sigma | 1983 |
Naloxone-inaccessible sigma receptor in rat central nervous system.
Topics: Animals; Binding, Competitive; Brain; Cyclazocine; Enkephalins; Ethylketocyclazocine; Kinetics; Naloxone; Phenazocine; Phencyclidine; Rats; Receptors, Opioid; Receptors, sigma; Spinal Cord; Tissue Distribution | 1983 |
N-allylnormetazocine (SKF-10,047): the induction of feeding by a putative sigma agonist.
Topics: Animals; Cyclazocine; Dose-Response Relationship, Drug; Drug Interactions; Eating; Ethylketocyclazocine; Male; Morphine; Naloxone; Phenazocine; Rats; Rats, Inbred Strains; Receptors, Opioid | 1983 |
Blockade of long-term potentiation by phencyclidine and sigma opiates in the hippocampus in vivo and in vitro.
Topics: Animals; Cyclazocine; Drug Synergism; Hippocampus; Male; Membrane Potentials; Morphine; Naloxone; Narcotics; Phenazocine; Phencyclidine; Pyramidal Tracts; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Synapses; Synaptic Transmission | 1983 |
Effects of SKF-10047 in the phencyclidine-dependent rat: evidence for common receptor mechanisms.
Topics: Animals; Drug Tolerance; Female; Humans; Phenazocine; Phencyclidine; Rats; Receptors, Opioid; Receptors, sigma; Substance Withdrawal Syndrome | 1983 |
Discriminative stimulus properties of nalorphine in the rhesus monkeys.
Topics: Animals; Benzodiazepines; Benzomorphans; Conditioning, Operant; Cyclazocine; Discrimination Learning; Dose-Response Relationship, Drug; Ethylketocyclazocine; Macaca mulatta; Male; Nalorphine; Naloxone; Phenazocine; Receptors, Opioid; Receptors, Opioid, kappa | 1983 |
[3H]-SKF 10047 binding to rat brain membranes: evidence for kappa isoreceptors.
Topics: Animals; Brain; Cell Membrane; Phenazocine; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1983 |
Similar anticonvulsant, but unique, behavioural effects of opioid agonists in the seizure-sensitive Mongolian gerbil.
Topics: Animals; Anticonvulsants; Behavior, Animal; Cyclazocine; Electroencephalography; Ethylketocyclazocine; Female; Gerbillinae; Male; Morphine; Narcotics; Phenazocine; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Seizures | 1984 |
Further characterization of the three-choice morphine, cyclazocine and saline discrimination paradigm: opioids with agonist and antagonist properties.
Topics: Animals; Cyclazocine; Discrimination Learning; Discrimination, Psychological; Ethylketocyclazocine; Male; Morphine; Narcotic Antagonists; Narcotics; Phenazocine; Phencyclidine; Rats; Sodium Chloride; Stereoisomerism | 1983 |
Phencyclidine-induced inhibition of striatal acetylcholine release: comparisons with mu, kappa, and sigma opiate agonists.
Topics: Acetylcholine; Animals; Corpus Striatum; Cyclazocine; Ethylketocyclazocine; Haloperidol; Male; Morphine; Naloxone; Narcotic Antagonists; Phenazocine; Phencyclidine; Rats; Rats, Inbred Strains | 1984 |
Effects of opioids on accuracy of a fixed-ratio discrimination in monkeys and rats.
Topics: Animals; Buprenorphine; Cyclazocine; Discrimination Learning; Dose-Response Relationship, Drug; Erythrocebus patas; Ethylketocyclazocine; Isomerism; Macaca mulatta; Male; Methadone; Morphinans; Morphine; Phenazocine; Rats | 1984 |
Three-choice drug discrimination: phencyclidine-like stimulus effects of opioids.
Topics: Animals; Choice Behavior; Cyclazocine; Dextroamphetamine; Discrimination, Psychological; Male; Naltrexone; Phenazocine; Phencyclidine; Rats; Rats, Inbred Strains; Secobarbital | 1983 |
Behavioral interactions of opioid agonists and antagonists with serotonergic systems.
Topics: Animals; Brain; Conditioning, Operant; Cyclazocine; DOM 2,5-Dimethoxy-4-Methylamphetamine; Dose-Response Relationship, Drug; Ethylketocyclazocine; Lysergic Acid Diethylamide; Male; Metergoline; Naloxone; Narcotic Antagonists; Narcotics; Phenazocine; Quipazine; Rats; Rats, Inbred Strains; Receptors, Serotonin; Reinforcement Schedule | 1984 |
Spike and wave complexes produced by four hallucinogenic compounds in the cat.
Topics: Animals; Behavior, Animal; Cats; Electroencephalography; Hallucinogens; Ketamine; Limbic System; Phenazocine; Phencyclidine; Quipazine | 1984 |
Agonist and antagonist effects of prototype opiate drugs in rats discriminating fentanyl from saline: characteristics of partial generalization.
Topics: Animals; Conditioning, Operant; Cyclazocine; Discrimination Learning; Ethylketocyclazocine; Fentanyl; Male; Morphine; Nalorphine; Naloxone; Narcotics; Phenazocine; Rats; Rats, Inbred Strains; Sodium Chloride | 1984 |
Pharmacologic effects of N-allylnormetazocine (SKF-10047).
Topics: Analgesics; Animals; Behavior, Animal; Clonidine; Cyclazocine; Ethylketocyclazocine; Male; Morphine; Motor Activity; Phenazocine; Rats; Receptors, Dopamine; Spiperone | 1981 |
Discriminative stimulus effects of etorphine in Rhesus monkeys.
Topics: Animals; Codeine; Cyclazocine; Discrimination Learning; Ethylketocyclazocine; Etorphine; Macaca mulatta; Male; Meperidine; Morphinans; Morphine; Pentazocine; Phenazocine; Sodium Chloride | 1981 |
Progress report from the NIDA Addiction Research Center (Preclinical Laboratory), Lexington, Ky.
Topics: Animals; Binding Sites; Dogs; Guinea Pigs; Humans; Male; Middle Aged; National Institutes of Health (U.S.); Nicotine; Opioid-Related Disorders; Opium; Phenazocine; Saimiri; Self Administration; Substance-Related Disorders; Tobacco Use Disorder; United States | 1982 |
Phencyclidine-like discriminative stimulus properties of opioids in the squirrel monkey.
Topics: Animals; Cyclazocine; Discrimination Learning; Female; Male; Naltrexone; Narcotics; Phenazocine; Phencyclidine; Saimiri; Time Factors | 1982 |
Pharmacological evaluation of N-allynormetazocine (SKF 10,047) on the basis of its discriminative stimulus properties in the rat.
Topics: Animals; Benzomorphans; Discrimination Learning; Dose-Response Relationship, Drug; Drug Interactions; Male; Naloxone; Phenazocine; Phencyclidine; Propranolol; Rats; Rats, Inbred F344; Stereoisomerism | 1983 |
Subclasses of opioids based on body temperature change in rats: acute subcutaneous administration.
Topics: Animals; Body Temperature; Buprenorphine; Dose-Response Relationship, Drug; Endorphins; Injections, Subcutaneous; Male; Meperidine; Morphine; Nalbuphine; Naloxone; Pentazocine; Phenazocine; Rats; Rats, Inbred Strains | 1983 |
Antitussive effect of the optical isomers of mu, kappa and sigma opiate agonists/antagonists in the cat.
Topics: Animals; Antitussive Agents; Blood Pressure; Cats; Codeine; Cyclazocine; Dextromethorphan; Female; Heart Rate; Male; Methadone; Morphine; Narcotics; Phenazocine; Stereoisomerism | 1983 |
Differential effects of prototype opioid agonists on the acquisition of conditional discriminations in monkeys.
Topics: Animals; Behavior, Animal; Conditioning, Psychological; Cyclazocine; Discrimination Learning; Dose-Response Relationship, Drug; Erythrocebus patas; Ethylketocyclazocine; Male; Morphine; Pentazocine; Phenazocine; Psychomotor Performance | 1983 |
Acquisition of brightness discrimination in the rat is impaired by opiates with psychotomimetic properties.
Topics: Animals; Avoidance Learning; Cyclazocine; Discrimination Learning; Male; Morphine; Nalorphine; Naltrexone; Narcotics; Pentazocine; Phenazocine; Photic Stimulation; Psychotropic Drugs; Rats; Rats, Inbred F344 | 1983 |
Tolerance to and physical dependence on N-allylnormetazocine (NANM) in chronic spinal dogs.
Topics: Animals; Body Temperature; Decerebrate State; Dogs; Drug Tolerance; Eating; Female; Humans; Naltrexone; Phenazocine; Pulse; Pupil; Reflex; Substance-Related Disorders | 1980 |
Differential effects of SKF 10,047 (N-allyl-normetazocine) on peristalsis and longitudinal muscle contractions of the isolated guinea-pig ileum.
Topics: Animals; Electric Stimulation; Enkephalins; Gastrointestinal Motility; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Peristalsis; Phenazocine | 1982 |
Phencyclidine-like discriminative stimuli of (+)- and (-)-N-allylnormetazocine in rats.
Topics: Animals; Discrimination Learning; Discrimination, Psychological; Male; Naloxone; Phenazocine; Phencyclidine; Rats; Rats, Inbred F344; Reinforcement Schedule; Stereoisomerism | 1982 |
(+)-N-allylnormetazocine enhances N-acetyltransferase activity and melatonin synthesis: preliminary evidence for a functional role of sigma receptors in the rat pineal gland.
Topics: Animals; Antipsychotic Agents; Arylamine N-Acetyltransferase; Carbazoles; Male; Melatonin; Phenazocine; Pineal Gland; Rats; Rats, Sprague-Dawley; Receptors, sigma | 1995 |
Effect of the 5-hydroxytryptamine3 receptor antagonist itasetron (DAU 6215) on (+)-N-allylnormetazocine-induced dopamine release in the nucleus accumbens and in the corpus striatum of the rat: an in vivo microdialysis study.
Topics: Animals; Antipsychotic Agents; Benzimidazoles; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Corpus Striatum; Dialysis; Dopamine; Drug Interactions; Male; Microchemistry; Nucleus Accumbens; Phenazocine; Potassium; Rats; Rats, Sprague-Dawley; Serotonin Antagonists | 1995 |
Intrahippocampal administration of (+)-SKF 10,047, a sigma ligand, reverses MK-801-induced impairment of working memory in rats.
Topics: Animals; Binding Sites; Dizocilpine Maleate; Dose-Response Relationship, Drug; Hippocampus; Male; Memory; Phenazocine; Rats; Rats, Wistar | 1995 |
Pharmacological evidence for the involvement of sigma sites in DTG-induced contralateral circling in rats.
Topics: Animals; Anticonvulsants; Behavior, Animal; Carbazoles; Dose-Response Relationship, Drug; Guanidines; Haloperidol; Injections, Spinal; Male; Motor Activity; Phenazocine; Raclopride; Rats; Rats, Sprague-Dawley; Receptors, sigma; Salicylamides | 1995 |
Phosphorylation of synapsin I and dynamin in rat forebrain synaptosomes: modulation by sigma (sigma) ligands.
Topics: Animals; Anticonvulsants; Dynamins; GTP Phosphohydrolases; Guanidines; Haloperidol; In Vitro Techniques; Microtubules; Pentazocine; Phenazocine; Phosphorylation; Prosencephalon; Rats; Receptors, sigma; Synapsins; Synaptosomes | 1995 |
Oocytes from Xenopus laevis contain an intrinsic sigma 2-like binding site.
Topics: Animals; Binding Sites; Binding, Competitive; Carbazoles; Dextromethorphan; Female; Guanidines; Haloperidol; Liver; Mazindol; Oocytes; Pentazocine; Phenazocine; Piperazines; Piperidines; Radioligand Assay; Rats; Receptors, sigma; Xenopus laevis; Zinc | 1994 |
Differential effects of peptide YY, neuropeptide Y, and sigma ligands on neurally stimulated external pancreatic secretion in the rat.
Topics: Animals; Fistula; Guanidines; Male; Neuropeptide Y; Pancreas; Peptide YY; Peptides; Phenazocine; Rats; Rats, Wistar | 1995 |
Purification, pharmacological characterization and photoaffinity labeling of sigma receptors from rat and bovine brain.
Topics: Animals; Binding Sites; Cattle; Cerebellum; Dopamine Agonists; Haloperidol; Male; Phenazocine; Piperidines; Rats; Receptors, sigma | 1995 |
Sigma receptor-mediated neuroprotection against glutamate toxicity in primary rat neuronal cultures.
Topics: Animals; Calcium; Cells, Cultured; Cyclazocine; Cyclopentanes; Dextromethorphan; Glutamic Acid; Guanidines; Haloperidol; L-Lactate Dehydrogenase; Neurons; Neuroprotective Agents; Pentazocine; Phenazocine; Piperidines; Rats; Receptors, sigma | 1995 |
Acute effects of sigma ligands on the extracellular DOPAC level in rat frontal cortex and striatum.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Anticonvulsants; Antipsychotic Agents; Carbazoles; Corpus Striatum; Extracellular Space; Frontal Lobe; Guanidines; Kinetics; Ligands; Male; Microdialysis; Pentazocine; Phenazocine; Piperidines; Rats; Rats, Wistar; Receptors, sigma; Time Factors | 1995 |
Effects of sigma and phencyclidine receptor ligands on electric field-stimulated rabbit ear artery constriction in vitro.
Topics: Animals; Arteries; Dizocilpine Maleate; Ear; Electric Stimulation; Female; In Vitro Techniques; Ligands; Male; Pentazocine; Phenazocine; Phencyclidine; Rabbits; Receptors, Phencyclidine; Receptors, sigma; Vasoconstriction | 1994 |
Neuroendocrine responses produced by enantiomeric pairs of drugs that interact with phencyclidine and sigma receptors.
Topics: Adrenocorticotropic Hormone; Analgesics; Animals; Corticosterone; Dioxolanes; Drug Interactions; Hypothalamo-Hypophyseal System; Injections, Subcutaneous; Male; Phenazocine; Phencyclidine; Piperidines; Pituitary-Adrenal System; Rats; Rats, Sprague-Dawley; Receptors, sigma; Stereoisomerism; Sympathomimetics | 1994 |
Low dose of 1,3-di(2-tolyl)guanidine (DTG) attenuates MK-801-induced spatial working memory impairment in mice.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Dizocilpine Maleate; Dose-Response Relationship, Drug; Guanidines; Male; Memory; Mice; Mice, Inbred Strains; Motor Activity; Pentazocine; Phenazocine; Pyrimidines; Receptors, sigma; Space Perception | 1994 |
Sensitive and rapid behavioral differentiation of N-methyl-D-aspartate receptor antagonists.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Behavior, Animal; Binding, Competitive; Central Nervous System Depressants; Dose-Response Relationship, Drug; Male; Mice; Motor Activity; Phenazocine; Receptors, N-Methyl-D-Aspartate; Receptors, Phencyclidine | 1994 |
Antagonism of the discriminative stimulus effects of the kappa-opioid agonist spiradoline.
Topics: Analgesics; Animals; Avoidance Learning; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Male; Narcotics; Phenazocine; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Stereoisomerism | 1994 |
NE-100, a novel sigma receptor ligand: in vivo tests.
Topics: Animals; Anisoles; Antipsychotic Agents; Behavior, Animal; Binding, Competitive; Catalepsy; Dopamine Agents; Drug Interactions; Locomotion; Male; Phenazocine; Phencyclidine; Propylamines; Radioligand Assay; Rats; Rats, Inbred Strains; Rats, Wistar; Receptors, sigma; Stereotyped Behavior | 1993 |
A comparison of (+)SK&F 10047 and MK-801 on cortical spreading depression.
Topics: Animals; Cerebrovascular Circulation; Cortical Spreading Depression; Dizocilpine Maleate; Dose-Response Relationship, Drug; Electroencephalography; Hyperemia; Injections, Intravenous; Male; Microinjections; N-Methylaspartate; Phenazocine; Potassium Chloride; Rats; Rats, Sprague-Dawley; Stereotaxic Techniques | 1994 |
SKF-10,047 reverses stress-induced motor suppression: interaction with dopaminergic system.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Anticonvulsants; Apomorphine; Dopamine; Electroshock; Guanidines; Male; Methamphetamine; Mice; Mice, Inbred Strains; Motor Activity; Oxidopamine; Pentazocine; Phenazocine; Pimozide; Pyrimidines; Receptors, sigma; Stress, Psychological | 1994 |
Regulation of [3H]dopamine release from rat striatal slices by sigma receptor ligands.
Topics: Animals; Atropine; Corpus Striatum; Dopamine; Flavonoids; In Vitro Techniques; N-Methylaspartate; Naloxone; Pentazocine; Phenazocine; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, sigma | 1994 |
Sigma-1 and sigma-2 sites in rat brain: comparison of regional, ontogenetic, and subcellular patterns.
Topics: Animals; Anticonvulsants; Brain; Brain Chemistry; Dizocilpine Maleate; Female; Guanidines; In Vitro Techniques; Male; Membranes; Phenazocine; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, sigma; Subcellular Fractions | 1994 |
Ameliorating effects of sigma receptor ligands on the impairment of passive avoidance tasks in mice: involvement in the central acetylcholinergic system.
Topics: Acetylcholine; Amnesia; Animals; Anticonvulsants; Avoidance Learning; Brain; Cholinesterase Inhibitors; Dopamine Agonists; Electroshock; Guanidines; Ligands; Male; Memory; Mice; Mice, Inbred Strains; p-Chloroamphetamine; Phenazocine; Piperidines; Receptors, sigma; Serotonin Antagonists | 1994 |
Characterization of specific (+)-[3H]N-allylnormetazocine and [3H]1,3-di(2-tolyl)guanidine binding sites in porcine gastric fundic mucosa.
Topics: Animals; Binding Sites; Gastric Fundus; Gastric Mucosa; Guanidines; Haloperidol; Phenazocine; Receptors, sigma; Swine | 1994 |
The sigma compounds 1,3-di-o-tolylguanidine and N-allylnormetazocine inhibit agonist-stimulated inositol phospholipid metabolism in bovine adrenal medullary cells.
Topics: Adrenal Medulla; Angiotensin II; Animals; Anticonvulsants; Cattle; Cells, Cultured; Dose-Response Relationship, Drug; Guanidines; Histamine; Inositol; Inositol Phosphates; Kinetics; Muscarine; Phenazocine; Phosphatidylinositols; Tritium | 1994 |
Enhancement of the opiate withdrawal response by antipsychotic drugs in guinea-pigs is not mediated by sigma binding sites.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Atropine; Behavior, Animal; Clozapine; Dizocilpine Maleate; Female; Guinea Pigs; Ketamine; Kinetics; Male; Morphine; Motor Activity; Naloxone; Phenazocine; Raclopride; Radioligand Assay; Receptors, sigma; Remoxipride; Salicylamides; Substance Withdrawal Syndrome | 1993 |
Monoamine oxidase inhibitors inhibit [3H]quinpirole binding in rat striatal membranes.
Topics: Animals; Apomorphine; Binding, Competitive; Corpus Striatum; Dopamine Agents; Ergolines; In Vitro Techniques; Kinetics; Male; Membranes; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Phenazocine; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, sigma; Spiperone | 1993 |
FH-510, a potent and selective ligand for rat brain sigma recognition sites.
Topics: Animals; Anti-Anxiety Agents; Binding, Competitive; Brain; Carbazoles; Dopamine; Haloperidol; Male; Mice; Phenazocine; Phencyclidine; Propylamines; Pyrimidines; Rats; Rats, Wistar; Receptors, sigma; Stereotyped Behavior | 1993 |
Binding of [3H]FH-510 to sigma ligand recognition sites in guinea-pig brain membranes.
Topics: Animals; Anti-Anxiety Agents; Binding Sites; Binding, Competitive; Brain; Carbazoles; Dopamine Agents; Guinea Pigs; Histamine; In Vitro Techniques; Kinetics; Male; Microsomes; Phenazocine; Piperidines; Propylamines; Pyrimidines; Radioligand Assay; Receptors, sigma; Serotonin | 1993 |
Antagonism of a (+)N-allylnormetazocine stimulus by (-)PPAP and several structurally related analogs.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amines; Animals; Antipsychotic Agents; Buspirone; Carbazoles; Generalization, Stimulus; Male; Phenazocine; Phenols; Piperazines; Propylamines; Rats; Rats, Sprague-Dawley; Receptors, Phencyclidine; Receptors, sigma; Serotonin Receptor Agonists | 1993 |
Area tempestas modulates the behavioural responses to nociceptive stimuli in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Anticonvulsants; Azocines; Bicuculline; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Escape Reaction; Foot; Hot Temperature; Male; Morphine; Naltrexone; Narcotic Antagonists; Olfactory Pathways; Pain; Phenazocine; Pressure; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid; Seizures; Tail | 1993 |
Effect of phencyclidine on contraction of porcine coronary vessel strips.
Topics: Animals; Biological Assay; Coronary Vessels; Dextromethorphan; Dizocilpine Maleate; Haloperidol; In Vitro Techniques; Muscle, Smooth, Vascular; Myocardial Contraction; Phenazocine; Phencyclidine; Receptors, Phencyclidine; Receptors, sigma; Swine | 1993 |
Effects of some opiates and opioid peptide eyedrops on ocular melatonin regulation in rabbits.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Binding Sites; Endorphins; Female; Melatonin; Ophthalmic Solutions; Phenazocine; Pyrrolidines; Rabbits; Radioimmunoassay; Receptors, Opioid; Retina; Uvea | 1993 |
Different sensitivities of NMDA receptor channel subtypes to non-competitive antagonists.
Topics: Amino Acid Sequence; Animals; Dizocilpine Maleate; Ketamine; Magnesium; Molecular Sequence Data; Mutagenesis; Oocytes; Phenazocine; Phencyclidine; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Xenopus | 1993 |
Evidence for in vivo interactions between neuropeptide Y-related peptides and sigma receptors in the mouse hippocampal formation.
Topics: Animals; Binding, Competitive; Epinephrine; Gastrointestinal Hormones; Haloperidol; Hippocampus; Kinetics; Male; Mice; Mice, Inbred Strains; Neuropeptide Y; Neurotensin; Peptide YY; Peptides; Phenazocine; Receptors, sigma; Vasoactive Intestinal Peptide | 1993 |
[3H]1-(cyclopropylmethyl)-4-(2-(4-fluorophenyl)-2-oxoethyl) piperidine HBr (DuP 734). A selective ligand for sigma receptors in mouse brain in vivo.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred Strains; Phenazocine; Piperidines; Protein Binding; Receptors, sigma; Serotonin Antagonists; Tritium | 1993 |
Identification of the benzomorphan opiate binding site on the catalytic subunit of acetylcholinesterase.
Topics: Acetylcholinesterase; Affinity Labels; Amino Acid Sequence; Animals; Catalysis; Cholinesterase Inhibitors; In Vitro Techniques; Models, Molecular; Molecular Sequence Data; Phenazocine; Photochemistry; Receptors, Opioid; Torpedo | 1993 |
Discriminative stimulus effects of the PCP/sigma-ligand (+)-N-allylnormetazocine in monkeys.
Topics: Animals; Discrimination Learning; Generalization, Stimulus; Ligands; Male; Naltrexone; Narcotics; Phenazocine; Receptors, Phencyclidine; Receptors, sigma; Saimiri | 1993 |
Correlation between potentiation of neurogenic twitch contraction and benzomorphan sigma receptor binding potency in the mouse vas deferens.
Topics: Animals; Antiparkinson Agents; Brain; Drug Synergism; Guinea Pigs; Haloperidol; Ligands; Male; Mice; Phenazocine; Piperidines; Receptors, sigma; Spasm; Vas Deferens | 1993 |
Effects of neuropeptide Y, peptide YY and sigma ligands on ion transport in mouse jejunum.
Topics: Animals; Cinnamates; Cyclopropanes; Guanidines; In Vitro Techniques; Ion Transport; Jejunum; Male; Mice; Mice, Inbred ICR; Neuropeptide Y; Peptide YY; Peptides; Phenazocine; Receptors, sigma | 1993 |
Dose-dependent effects of D-N-allylnormetazocine on regional cerebral metabolic rates for glucose.
Topics: Animals; Blood Glucose; Blood Pressure; Brain Chemistry; Brain Mapping; Deoxyglucose; Dose-Response Relationship, Drug; Glucose; Heart Rate; Male; Phenazocine; Phencyclidine; Rats; Rats, Inbred F344; Receptors, Phencyclidine; Receptors, sigma | 1993 |
Allosteric modulation of ligand binding to [3H](+)pentazocine-defined sigma recognition sites by phenytoin.
Topics: Allosteric Regulation; Animals; Binding Sites; Cyclopentanes; Dextromethorphan; Dextrorphan; Guinea Pigs; Ligands; Male; Pentazocine; Phenazocine; Phenytoin; Piperidines; Radioligand Assay; Receptors, sigma; Tritium | 1993 |
In vivo modulation of sigma receptor sites by calcitonin gene-related peptide in the mouse and rat hippocampal formation: radioligand binding and electrophysiological studies.
Topics: Animals; Antipsychotic Agents; Calcitonin Gene-Related Peptide; Dopamine Antagonists; Electrophysiology; Haloperidol; Hippocampus; In Vitro Techniques; Iontophoresis; Male; Membranes; Mice; Narcotics; Neuropeptide Y; Pentazocine; Phenazocine; Pyramidal Cells; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, sigma | 1995 |
Involvement of sigma 1 receptor in (+)-N-allylnormetazocine-stimulated hippocampal cholinergic functions in rats.
Topics: Acetylcholine; Amnesia; Analysis of Variance; Animals; Haloperidol; Hippocampus; Male; Muscarinic Antagonists; Phenazocine; Rats; Rats, Wistar; Receptors, sigma; Scopolamine; Stereoisomerism; Stimulation, Chemical; Synaptic Transmission | 1995 |
Autoradiographic evidence for the modulation of in vivo sigma receptor labeling by neuropeptide Y and calcitonin gene-related peptide in the mouse brain.
Topics: Animals; Antipsychotic Agents; Autoradiography; Binding Sites; Brain; Calcitonin Gene-Related Peptide; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Neuropeptide Y; Phenazocine; Rats; Receptors, sigma; Tritium | 1996 |
Sigma receptor modulation of noradrenergic-stimulated pineal melatonin biosynthesis in rats.
Topics: Animals; Anticonvulsants; Antipsychotic Agents; Arylamine N-Acetyltransferase; Circadian Rhythm; Darkness; Guanidines; Isoproterenol; Male; Melatonin; Norepinephrine; Phenazocine; Pineal Gland; Rats; Rats, Wistar; Receptors, sigma; Sympathomimetics | 1996 |
Involvement of sigma-receptors in the increase in contraction of mouse vas deferens induced by exogenous ATP.
Topics: Adenosine Triphosphate; Analgesics, Opioid; Animals; Anticonvulsants; Antipsychotic Agents; Carbazoles; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Synergism; Guanidines; Haloperidol; Ligands; Male; Mice; Muscle Contraction; Muscle, Smooth; Pentazocine; Phenazocine; Piperidines; Receptors, sigma; Regression Analysis; Structure-Activity Relationship; Vas Deferens | 1996 |
Differential solubilization of rat liver sigma 1 and sigma 2 receptors: retention of sigma 2 sites in particulate fractions.
Topics: Animals; Binding, Competitive; Cell Fractionation; Cell Membrane; Cholic Acids; Detergents; Guanidines; Haloperidol; In Vitro Techniques; Liver; Male; Pentazocine; Phenazocine; Protein Binding; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, sigma; Solubility; Subcellular Fractions | 1996 |
The effects of (+)-SKF10047 and ketamine hydrochloride on stereotyped behaviour, locomotor activity and ataxia in guinea pig.
Topics: Animals; Ataxia; Guinea Pigs; Ketamine; Motor Activity; Phenazocine; Reaction Time; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Stereotyped Behavior | 1996 |
Regional differences of the effect of sigma receptor ligands on the acetylcholine release in the rat brain.
Topics: Acetylcholine; Animals; Anticonvulsants; Antipsychotic Agents; Brain Chemistry; Extracellular Space; Guanidines; Hippocampus; Ligands; Male; Neostriatum; Neurotransmitter Agents; Phenazocine; Rats; Rats, Wistar; Receptors, sigma | 1996 |
Enhancement of acetylcholine release by SA4503, a novel sigma 1 receptor agonist, in the rat brain.
Topics: Acetylcholine; Animals; Brain; Haloperidol; Male; Phenazocine; Piperazines; Rats; Rats, Wistar; Receptors, sigma; Tacrine; Tetrodotoxin | 1996 |
Effects of sigma ligands on the cloned mu-, delta- and kappa-opioid receptors co-expressed with G-protein-activated K+ (GIRK) channel in Xenopus oocytes.
Topics: Animals; Brain Chemistry; Cyclazocine; Cyclopentanes; Dose-Response Relationship, Drug; GTP-Binding Proteins; Ligands; Oocytes; Phenazocine; Potassium Channels; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, sigma; RNA, Messenger; Xenopus laevis | 1996 |
(+)-SKF-10,047 and dextromethorphan ameliorate conditioned fear stress via dopaminergic systems linked to phenytoin-regulated sigma 1 sites.
Topics: Animals; Benzazepines; Conditioning, Classical; Dextromethorphan; Dopamine Antagonists; Drug Interactions; Fear; Male; Mice; Neurons; Oxidopamine; Phenazocine; Phenytoin; Receptors, Dopamine; Receptors, sigma; Sulpiride | 1996 |
IP3 receptor antagonist heparin uncompetitively inhibits [3H](+)-SKF-10047 binding to sigma receptors.
Topics: Animals; Brain; Calcium Channels; Endoplasmic Reticulum; Heparin; In Vitro Techniques; Inositol 1,4,5-Trisphosphate Receptors; Kinetics; Microsomes; Microsomes, Liver; Phenazocine; Rats; Receptors, Cytoplasmic and Nuclear; Receptors, Opioid, delta; Ryanodine | 1996 |
Beneficial effects of sigma agonists on the age-related learning impairment in the senescence-accelerated mouse (SAM).
Topics: Aging; Animals; Anti-Anxiety Agents; Antipsychotic Agents; Avoidance Learning; Cinnamates; Cyclopropanes; Learning; Maze Learning; Memory; Mice; Mice, Neurologic Mutants; Morpholines; Motor Activity; Phenazocine; Pyrimidines; Receptors, sigma | 1996 |
(+)-SKF-10,047 and dextromethorphan ameliorate conditioned fear stress through the activation of phenytoin-regulated sigma 1 sites.
Topics: Animals; Anti-Anxiety Agents; Antipsychotic Agents; Behavior, Animal; Dextromethorphan; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Male; Mice; Motor Activity; Phenazocine; Phencyclidine; Phenytoin; Pyrimidines; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Stress, Physiological | 1996 |
Modulation by neurosteroids of the in vivo (+)-[3H]SKF-10,047 binding to sigma 1 receptors in the mouse forebrain.
Topics: Animals; Antipsychotic Agents; Binding, Competitive; Cerebral Cortex; Dehydroepiandrosterone Sulfate; Dose-Response Relationship, Drug; Female; Gonadal Steroid Hormones; Hippocampus; Male; Mice; Phenazocine; Pregnancy; Pregnenolone; Progesterone; Prosencephalon; Rats; Rats, Sprague-Dawley; Receptors, sigma; Tritium | 1996 |
Differential localization of three distinct binding sites for sigma receptor ligands in rat spleen.
Topics: Analgesics, Opioid; Animals; Anticonvulsants; Antipsychotic Agents; Autoradiography; Binding Sites; Dopamine Agonists; Dopamine Antagonists; Female; Guanidines; Haloperidol; Image Processing, Computer-Assisted; Ligands; Male; Naltrexone; Narcotic Antagonists; Pentazocine; Phenazocine; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, sigma; Spleen; Tritium | 1997 |
In vivo functional interaction between phencyclidine binding sites and sigma receptors to produce head-weaving behavior in rats.
Topics: Animals; Anisoles; Behavior, Animal; Binding Sites; Dizocilpine Maleate; Guanidines; Male; Phenazocine; Piperidines; Propylamines; Pyrimidines; Rats; Rats, Wistar; Receptors, Phencyclidine; Receptors, sigma | 1996 |
Naloxone-sensitive, haloperidol-sensitive, [3H](+)SKF-10047-binding protein partially purified from rat liver and rat brain membranes: an opioid/sigma receptor?
Topics: Animals; Antipsychotic Agents; Brain; Haloperidol; Liver; Naloxone; Phenazocine; Radioligand Assay; Rats; Receptors, Opioid | 1997 |
Reduction of the scopolamine-induced impairment of passive-avoidance performance by sigma receptor agonist in mice.
Topics: Acetylcholinesterase; Animals; Antipsychotic Agents; Avoidance Learning; Brain; Dose-Response Relationship, Drug; Guanidines; Male; Mental Recall; Mice; Mice, Inbred Strains; Phenazocine; Piperidines; Receptors, sigma; Scopolamine | 1997 |
The involvement of sigma receptors in the choice reaction performance deficits induced by phencyclidine.
Topics: Animals; Anisoles; Antipsychotic Agents; Excitatory Amino Acid Agonists; Ligands; Male; Phenazocine; Phencyclidine; Piperidines; Propylamines; Psychomotor Performance; Rats; Rats, Wistar; Reaction Time; Receptors, sigma | 1997 |
Role of (+)-SKF-10,047-sensitive sub-population of sigma 1 receptors in amelioration of conditioned fear stress in rats: association with mesolimbic dopaminergic systems.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antipsychotic Agents; Brain Chemistry; Conditioning, Psychological; Dopamine; Dose-Response Relationship, Drug; Fear; Homovanillic Acid; Limbic System; Male; Phenazocine; Rats; Rats, Wistar; Receptors, sigma; Stress, Psychological | 1997 |
Antinociception induced by opioid or 5-HT agonists microinjected into the anterior pretectal nucleus of the rat.
Topics: Analgesics; Animals; Benzomorphans; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Microinjections; Pain; Phenazocine; Piperazines; Quinoxalines; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Serotonin; Serotonin Receptor Agonists | 1997 |
Biological profile of L-745,870, a selective antagonist with high affinity for the dopamine D4 receptor.
Topics: Animals; CHO Cells; Cricetinae; Cyclic AMP; Dopamine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Male; Mice; Phenazocine; Prolactin; Pyridines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D4; Saimiri | 1997 |
Sigma receptor ligands (+)-SKF10,047 and SA4503 improve dizocilpine-induced spatial memory deficits in rats.
Topics: Animals; Ataxia; Dizocilpine Maleate; Dose-Response Relationship, Drug; Eating; Excitatory Amino Acid Antagonists; Male; Maze Learning; Memory Disorders; Nootropic Agents; Phenazocine; Piperazines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Receptors, sigma | 1998 |
Sigma1 receptor subtype does not interact with stereotyped behaviors in rats.
Topics: Animals; Antipsychotic Agents; Male; Nootropic Agents; Phenazocine; Phencyclidine; Piperazines; Rats; Rats, Wistar; Receptors, sigma; Stereotyped Behavior | 1998 |
Reduction of 4-cyclohexyl-1-[(1R)-1,2-diphenylethyl]-piperazine-induced memory impairment of passive avoidance performance by sigma 1 receptor agonists in mice.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Binding, Competitive; Brain Chemistry; Dopamine Agonists; Guinea Pigs; Male; Membranes; Memory Disorders; Mice; Phenazocine; Piperazines; Piperidines; Radioligand Assay; Receptors, sigma | 1998 |
Binding of [3H]desglycinyl remacemide to rat brain membranes: association with the benzomorphan attachment site of the N-methyl-D-aspartic acid receptor channel.
Topics: Animals; Antipsychotic Agents; Benzomorphans; Binding Sites; Brain Chemistry; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Haloperidol; Male; Membrane Proteins; Neurons; Phenazocine; Phencyclidine; Phenethylamines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Subcellular Fractions; Tritium | 1999 |
Sigma1 recognition sites in rabbit iris-ciliary body: topical sigma1-site agonists lower intraocular pressure.
Topics: Animals; Anisoles; Antipsychotic Agents; Binding, Competitive; Cell Membrane; Ciliary Body; Functional Laterality; Guanidines; Intraocular Pressure; Iris; Kinetics; Lens, Crystalline; Male; Pentazocine; Phenazocine; Propylamines; Rabbits; Receptors, sigma; Retina; Tritium | 1999 |
Sigma receptor photolabeling and sigma receptor-mediated modulation of potassium channels in tumor cells.
Topics: Antipsychotic Agents; Carcinoma, Small Cell; Cocaine; Guanosine Triphosphate; Humans; Iodine Radioisotopes; Ligands; Lung Neoplasms; Phenazocine; Photoaffinity Labels; Potassium Channels; Receptors, sigma; Signal Transduction; Tumor Cells, Cultured | 1999 |
Modulation of steroidal levels by adrenalectomy/castration and inhibition of neurosteroid synthesis enzymes affect sigma1 receptor-mediated behaviour in mice.
Topics: Adrenalectomy; Animals; Behavior, Animal; Brain; Cerebral Cortex; Dizocilpine Maleate; Enzyme Inhibitors; Finasteride; Hippocampus; Male; Mice; Morpholines; Orchiectomy; Phenazocine; Receptors, sigma; Spatial Behavior; Steroids | 1999 |
Intracellular sigma1 receptor modulates phospholipase C and protein kinase C activities in the brainstem.
Topics: Action Potentials; Animals; Antipsychotic Agents; Brain Stem; Cell Membrane; Cytoplasm; GTP-Binding Proteins; Guinea Pigs; Haloperidol; In Vitro Techniques; Isoenzymes; Ligands; Male; Pentazocine; Pertussis Toxin; Phenazocine; Protein Kinase C; Protein Kinase C beta; Receptors, sigma; Respiratory Mechanics; Reverse Transcriptase Polymerase Chain Reaction; Type C Phospholipases; Virulence Factors, Bordetella | 1999 |
Pharmacological profile of MS-377, a novel antipsychotic agent with selective affinity for sigma receptors.
Topics: Amisulpride; Animals; Antipsychotic Agents; Apomorphine; Catalepsy; Dopamine Agonists; Free Radical Scavengers; Guinea Pigs; Haloperidol; Head Movements; Male; Mice; Phenazocine; Phencyclidine; Piperazines; Pyrrolidines; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, Serotonin; Receptors, sigma; Risperidone; Serotonin; Serotonin Antagonists; Stereotyped Behavior; Sulpiride; Tartrates | 1999 |
sigma receptor ligands attenuate N-methyl-D-aspartate cytotoxicity in dopaminergic neurons of mesencephalic slice cultures.
Topics: Animals; Animals, Newborn; Cell Survival; Dopamine; Excitatory Amino Acid Agonists; Immunohistochemistry; Ligands; Mesencephalon; N-Methylaspartate; Neurons; Organ Culture Techniques; Phenazocine; Propylamines; Rats; Rats, Wistar; Receptors, sigma; Tyrosine 3-Monooxygenase | 2000 |
[Dependence of the pump function of the isolated rat heart on the functional activity of sigma receptors during reperfusion].
Topics: Animals; Blood Pressure; Creatine Kinase; Electrocardiography; Heart; Heart Rate; Myocardial Contraction; Myocardial Reperfusion Injury; Myocardium; Phenazocine; Piperidines; Rats; Rats, Wistar; Receptors, sigma; Ventricular Function, Left; Ventricular Pressure | 1999 |
Effects of trazodone on neurotransmitter release from rat mossy fibre cerebellar synaptosomes.
Topics: Animals; Antidepressive Agents, Second-Generation; Cerebellum; Ethylenediamines; gamma-Aminobutyric Acid; Glutamic Acid; Male; Nerve Fibers; Phenazocine; Piperidines; Potassium Chloride; Rats; Rats, Sprague-Dawley; Receptors, sigma; Serotonin; Synaptosomes; Trazodone | 2000 |
Membrane-delimited coupling between sigma receptors and K+ channels in rat neurohypophysial terminals requires neither G-protein nor ATP.
Topics: Adenosine Triphosphate; Analgesics, Opioid; Animals; Antipsychotic Agents; Cells, Cultured; Dose-Response Relationship, Drug; GTP-Binding Proteins; Guanosine Triphosphate; In Vitro Techniques; Ligands; Oocytes; Patch-Clamp Techniques; Pentazocine; Phenazocine; Phosphorylation; Pituitary Gland, Posterior; Potassium; Potassium Channels; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, sigma; Synaptic Membranes; Xenopus laevis | 2000 |
Neurosteroids ameliorate conditioned fear stress: an association with sigma receptors.
Topics: Animals; Antipsychotic Agents; Conditioning, Psychological; Dehydroepiandrosterone Sulfate; Electroshock; Fear; Male; Mice; Phenazocine; Pregnenolone; Receptors, sigma; Sigma-1 Receptor; Steroids; Stress, Psychological | 2000 |
Effects of sigma receptor agonists on the impairment of spontaneous alternation behavior and decrease of cyclic GMP level induced by nitric oxide synthase inhibitors in mice.
Topics: Analgesics, Opioid; Animals; Anti-Anxiety Agents; Antipsychotic Agents; Behavior, Animal; Brain Chemistry; Cyclic GMP; Enzyme Inhibitors; Guanidines; Indazoles; Male; Methylene Blue; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Pentazocine; Phenazocine; Pyrimidines; Receptors, sigma | 2000 |
Involvement of direct inhibition of NMDA receptors in the effects of sigma-receptor ligands on glutamate neurotoxicity in vitro.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Glutamic Acid; Haloperidol; Ligands; Neurons; Neuroprotective Agents; Phenazocine; Propylamines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, delta; RNA, Messenger | 2000 |
Phencyclidine impairs latent learning in mice: interaction between glutamatergic systems and sigma(1) receptors.
Topics: Animals; Antipsychotic Agents; Appetitive Behavior; Behavior, Animal; Cycloserine; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Exploratory Behavior; Glutamic Acid; Learning; Male; Mice; Mice, Inbred Strains; Narcotic Antagonists; Pentazocine; Phenazocine; Phencyclidine; Piperazines; Reaction Time; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Sigma-1 Receptor; Stereoisomerism | 2001 |
The anti-amnesic effects of sigma1 (sigma1) receptor agonists confirmed by in vivo antisense strategy in the mouse.
Topics: Amnesia; Animals; Brain; Dizocilpine Maleate; Excitatory Amino Acid Agonists; In Vitro Techniques; Learning Disabilities; Male; Maze Learning; Mice; Morpholines; Nootropic Agents; Oligonucleotides, Antisense; Phenazocine; Piperazines; Receptors, sigma | 2001 |
Involvement of the sigma receptor in passive-avoidance learning in the day-old chick during the second wave of neuronal activity.
Topics: Amnesia; Animals; Animals, Newborn; Antipsychotic Agents; Avoidance Learning; Chickens; Ethylenediamines; Olfactory Bulb; Phenazocine; Receptors, sigma; Synaptic Transmission | 2001 |
The antidepressant-like effect induced by sigma(1)-receptor agonists and neuroactive steroids in mice submitted to the forced swimming test.
Topics: Adrenalectomy; Animals; Antidepressive Agents; Behavior, Animal; Brain Chemistry; Dehydroepiandrosterone; Dose-Response Relationship, Drug; Male; Mice; Orchiectomy; Phenazocine; Radioimmunoassay; Receptors, Opioid, delta; Steroids; Swimming | 2001 |
Modulation of dopamine uptake in rat nucleus accumbens: effect of specific dopamine receptor antagonists and sigma ligands.
Topics: Animals; Antipsychotic Agents; Carbazoles; Dopamine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Female; Haloperidol; Ligands; Neurons; Nomifensine; Nucleus Accumbens; Phenazocine; Progesterone; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, sigma; Spiperone; Sulpiride; Synaptosomes; Tritium | 2001 |
Differential involvement of the sigma(1) (sigma(1)) receptor in the anti-amnesic effect of neuroactive steroids, as demonstrated using an in vivo antisense strategy in the mouse.
Topics: Amnesia; Animals; Avoidance Learning; Behavior, Animal; Binding Sites; Blotting, Western; Brain; Cerebral Cortex; Dehydroepiandrosterone; Dizocilpine Maleate; Dose-Response Relationship, Drug; Hippocampus; In Vitro Techniques; Learning Disabilities; Male; Maze Learning; Memory; Mice; Morpholines; Oligonucleotides, Antisense; Phenazocine; Pregnenolone; Receptors, sigma; Sigma-1 Receptor | 2001 |
Receptor mechanisms and circuitry underlying NMDA antagonist neurotoxicity.
Topics: Adrenergic alpha-Agonists; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Carbachol; Carbazoles; Cerebral Cortex; Clonidine; Dizocilpine Maleate; Drug Interactions; Excitatory Amino Acid Antagonists; Female; Kainic Acid; Models, Neurological; Muscarinic Antagonists; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Phenazocine; Prosencephalon; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, Muscarinic; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Scopolamine | 2002 |
The sigma receptor as a ligand-regulated auxiliary potassium channel subunit.
Topics: Animals; Antipsychotic Agents; Kv1.4 Potassium Channel; Kv1.5 Potassium Channel; Ligands; Oocytes; Patch-Clamp Techniques; Phenazocine; Pituitary Gland, Posterior; Potassium Channels; Potassium Channels, Voltage-Gated; Protein Structure, Secondary; Protein Subunits; Rats; Receptors, sigma; Recombinant Fusion Proteins; Signal Transduction; Xenopus laevis | 2002 |
MS-377, a selective sigma receptor ligand, indirectly blocks the action of PCP in the N-methyl-D-aspartate receptor ion-channel complex in primary cultured rat neuronal cells.
Topics: Animals; Antipsychotic Agents; Calcium; Cells, Cultured; Dizocilpine Maleate; Female; Ion Channels; Neurons; Phenazocine; Phencyclidine; Piperazines; Pregnancy; Pyrrolidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Sigma-1 Receptor; Tartrates; Tritium | 2002 |
Strain differences in sigma(1) receptor-mediated behaviours are related to neurosteroid levels.
Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Behavior, Animal; Binding Sites; Brain; Brain Chemistry; Cinnamates; Cocaine; Conditioning, Psychological; Cyclopropanes; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Morpholines; Neurons; Nootropic Agents; Phenazocine; Radioligand Assay; Receptors, sigma; Sigma-1 Receptor; Steroids | 2002 |
Effects of sigma(1) receptor ligand MS-377 on D(2) antagonists-induced behaviors.
Topics: Amisulpride; Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Catalepsy; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Drug Interactions; Female; Haloperidol; Male; Mice; Nootropic Agents; Phenazocine; Piperazines; Pyridines; Pyrrolidines; Rats; Receptors, sigma; Serotonin Antagonists; Sigma-1 Receptor; Sulpiride; Tartrates | 2002 |
Antagonism of NMDA receptors by sigma receptor ligands attenuates chemical ischemia-induced neuronal death in vitro.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium; Cell Hypoxia; Cell Survival; Cells, Cultured; Cerebral Cortex; Cyclopentanes; Deoxyglucose; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Fetus; Glucose; Glutamates; Haloperidol; Neurons; Phenazocine; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Sodium Azide | 2002 |
Activity of opioid ligands in cells expressing cloned mu opioid receptors.
Topics: Azocines; beta-Endorphin; Binding, Competitive; Butorphanol; Cell Line; Colforsin; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Etorphine; Fentanyl; Humans; Hydromorphone; Ligands; Morphine; Naltrexone; Phenazocine; Radioligand Assay; Receptors, Opioid, mu; Tritium | 2003 |
Anti-amnesic effect of dimemorfan in mice.
Topics: Amnesia; Amyloid beta-Peptides; Animals; Avoidance Learning; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred ICR; Morphinans; Peptide Fragments; Phenazocine; Receptors, sigma; Scopolamine | 2003 |
Generation and phenotypic analysis of sigma receptor type I (sigma 1) knockout mice.
Topics: Animals; Animals, Newborn; Antidepressive Agents; Antipsychotic Agents; Behavior, Animal; Binding, Competitive; Blotting, Northern; Blotting, Southern; Blotting, Western; Body Weight; Cells, Cultured; Embryo, Mammalian; Endorphins; Heterozygote; Hyperkinesis; In Situ Hybridization; Mice; Mice, Knockout; Narcotic Antagonists; Oligonucleotides, Antisense; Pentazocine; Peptide Fragments; Phenazocine; Phenotype; Radioligand Assay; Receptors, sigma; Sigma-1 Receptor; Time Factors | 2003 |
Antitussive activity of sigma-1 receptor agonists in the guinea-pig.
Topics: Animals; Antitussive Agents; Brain; Cough; Dextromethorphan; Dose-Response Relationship, Drug; Ethylenediamines; Guinea Pigs; Male; Phenazocine; Protein Binding; Receptors, sigma; Sigma-1 Receptor | 2004 |
Enhanced antidepressant efficacy of sigma1 receptor agonists in rats after chronic intracerebroventricular infusion of beta-amyloid-(1-40) protein.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antidepressive Agents; Brain; Cinnamates; Conditioning, Psychological; Cyclopropanes; Dehydroepiandrosterone; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Fear; Injections, Intraventricular; Male; Peptide Fragments; Phenazocine; Pregnenolone; Progesterone; Rats; Rats, Wistar; Receptors, sigma; Sigma-1 Receptor; Stress, Psychological | 2004 |
Characterization of phenothiazine-induced apoptosis in neuroblastoma and glioma cell lines: clinical relevance and possible application for brain-derived tumors.
Topics: Animals; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Calmodulin; Caspase 3; Caspases; Cell Division; Cell Line, Tumor; Cell Survival; DNA Fragmentation; Dose-Response Relationship, Drug; Fluphenazine; Glioma; Humans; Mice; Mice, Inbred ICR; Neuroblastoma; Phenazocine; Phenothiazines; Rats; Receptors, sigma; Thioridazine; Up-Regulation | 2004 |
Dimemorfan enhances acetylcholine release from rat hippocampal slices.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Acetylcholine; Animals; Antipsychotic Agents; Atropine; Carbachol; Cholinergic Agonists; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Haloperidol; Hippocampus; In Vitro Techniques; Male; Morphinans; Muscarinic Antagonists; Phenazocine; Potassium Chloride; Rats; Tritium | 2004 |
Involvement of the sigma 1 receptor in the modulation of dopaminergic transmission by amantadine.
Topics: Amantadine; Animals; Brain; Cell Line, Tumor; Dopamine; Dose-Response Relationship, Drug; Male; Mice; Phenazocine; Protein Binding; Rats; Rats, Wistar; Receptors, sigma; Sigma-1 Receptor; Synaptic Transmission | 2004 |
Characterization of the non-competitive antagonist binding site of the NMDA receptor in dark Agouti rats.
Topics: Animals; Binding, Competitive; Brain; Dextromethorphan; Dioxolanes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Female; Ketamine; N-Methylaspartate; Phenazocine; Phencyclidine; Piperidines; Rats; Rats, Mutant Strains; Receptors, N-Methyl-D-Aspartate; Scintillation Counting; Tritium | 2004 |
Phenytoin differentially modulates the affinity of agonist and antagonist ligands for sigma 1 receptors of guinea pig brain.
Topics: Allosteric Regulation; Animals; Anisoles; Anticonvulsants; Binding, Competitive; Brain; Dextromethorphan; Drug Interactions; Ethylenediamines; Guinea Pigs; Haloperidol; Ligands; Male; Morpholines; Neurons; Phenazocine; Phenytoin; Piperazines; Piperidines; Progesterone; Propylamines; Receptors, sigma; Synaptic Transmission | 2005 |
Age-related expression of sigma1 receptors and antidepressant efficacy of a selective agonist in the senescence-accelerated (SAM) mouse.
Topics: Age Factors; Aging; Animals; Antidepressive Agents; Antipsychotic Agents; Behavior, Animal; Blotting, Northern; Brain; Cinnamates; Cyclopropanes; Dehydroepiandrosterone; Dose-Response Relationship, Drug; Gene Expression Regulation; Immunohistochemistry; Male; Mice; Mice, Inbred Strains; Mice, Mutant Strains; Phenazocine; Pregnenolone; Progesterone; Radioligand Assay; Receptors, sigma; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Tritium | 2005 |
Effects of (+)SKF 10047, a sigma-1 selective agonist, on isolation-induced aggression in male mice.
Topics: Aggression; Animals; Behavior, Animal; Male; Mice; Phenazocine; Receptors, sigma; Social Isolation | 2006 |
Involvement of the sigma1 receptor in inhibiting activity of fluvoxamine on marble-burying behavior: comparison with paroxetine.
Topics: Animals; Behavior, Animal; Brain; Butyrates; Disease Models, Animal; Dose-Response Relationship, Drug; Ethylenediamines; Fluvoxamine; Male; Mice; Mice, Inbred ICR; Morpholines; Obsessive-Compulsive Disorder; Paroxetine; Phenazocine; Piperazines; Psychotropic Drugs; Receptors, sigma; Selective Serotonin Reuptake Inhibitors; Sigma-1 Receptor; Tropanes | 2007 |
sigma(2)-receptor ligand-mediated inhibition of inwardly rectifying K(+) channels in the heart.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Blood Pressure; Chlorocebus aethiops; COS Cells; Electrocardiography; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Female; Heart; Male; Phenazocine; Phenylephrine; Piperidines; Potassium Channel Blockers; Purkinje Fibers; Rabbits; Receptors, sigma | 2007 |
Inhibition of hyperpolarization-activated cation currents by phencyclidine and some sigma ligands in rat hippocampal CA1 pyramidal neurons in vitro.
Topics: Animals; Animals, Newborn; Cesium; Dizocilpine Maleate; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Antagonists; Hippocampus; In Vitro Techniques; Ion Channels; Membrane Potentials; Neural Inhibition; Patch-Clamp Techniques; Phenazocine; Phencyclidine; Pyramidal Cells; Pyrimidines; Rats; Rats, Wistar; Receptors, sigma | 2007 |
Sigma-1 receptors bind cholesterol and remodel lipid rafts in breast cancer cell lines.
Topics: Antipsychotic Agents; Biological Transport; Biotin; Breast Neoplasms; Cell Adhesion; Cell Membrane; Cells, Cultured; Cholesterol; Gene Silencing; Humans; Integrin beta1; Kidney; Membrane Lipids; Membrane Microdomains; Peptide Fragments; Phenazocine; Receptors, sigma; Sigma-1 Receptor; Signal Transduction | 2007 |
sigma-1 receptors protect RGC-5 cells from apoptosis by regulating intracellular calcium, Bax levels, and caspase-3 activation.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Calcium; Caspase 3; Cell Differentiation; Cell Line; Cell Survival; Cytoprotection; Enzyme Activation; Ethylenediamines; Female; Fluoresceins; Glutamic Acid; Male; Microscopy, Fluorescence; Phenazocine; Propidium; Rats; Rats, Inbred WKY; Receptors, sigma; Retinal Ganglion Cells; Sigma-1 Receptor; Transfection; Up-Regulation | 2008 |
Sigma-1 receptor regulation of voltage-gated calcium channels involves a direct interaction.
Topics: Animals; Blotting, Western; Calcium; Calcium Channels, L-Type; Cells, Cultured; DNA; Ethylenediamines; Gene Expression; Intracellular Fluid; Ion Channel Gating; Microscopy, Fluorescence; Molecular Sequence Data; Patch-Clamp Techniques; Phenazocine; Potassium Chloride; Rats; Receptors, sigma; Retinal Ganglion Cells; Sigma-1 Receptor; Signal Transduction | 2008 |
Sigma1 receptor antagonists determine the behavioral pattern of the methamphetamine-induced stereotypy in mice.
Topics: Animals; Behavior, Animal; Butyrates; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Drug Interactions; Ethylenediamines; Histamine H1 Antagonists; Ketotifen; Male; Methamphetamine; Mice; Mice, Inbred Strains; Motor Activity; Naphthalenes; Phenazocine; Piperazines; Pyrilamine; Pyrimidines; Receptors, sigma; Stereotyped Behavior; Tropanes | 2009 |
Voltage-gated sodium channel modulation by sigma-receptors in cardiac myocytes and heterologous systems.
Topics: Adenosine Triphosphate; Animals; Antipsychotic Agents; Cell Line; Chlorocebus aethiops; COS Cells; Guanosine Triphosphate; Haloperidol; Humans; Kidney; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle Proteins; Myocytes, Cardiac; Narcotics; NAV1.5 Voltage-Gated Sodium Channel; Patch-Clamp Techniques; Pentazocine; Phenazocine; Receptors, sigma; RNA, Small Interfering; Sodium; Sodium Channels | 2009 |
The C-terminal amidated analogue of the substance P (SP) fragment SP(1-7) attenuates the expression of naloxone-precipitated withdrawal in morphine dependent rats.
Topics: Animals; Antipsychotic Agents; Brain; Male; Morphine Dependence; Naloxone; Peptide Fragments; Phenazocine; Rats; Rats, Wistar; Substance P; Substance Withdrawal Syndrome | 2009 |
Antagonist action of progesterone at σ-receptors in the modulation of voltage-gated sodium channels.
Topics: Animals; Cells, Cultured; Guanidines; HEK293 Cells; Humans; Liver; N,N-Dimethyltryptamine; NAV1.5 Voltage-Gated Sodium Channel; Phenazocine; Piperazines; Progesterone; Rats; Receptors, sigma; RNA, Small Interfering; Sigma-1 Receptor; Sodium Channels | 2011 |
Sigma-1 receptor function is critical for both the discriminative stimulus and aversive effects of the kappa-opioid receptor agonist U-50488H.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Anisoles; Avoidance Learning; Conditioning, Psychological; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Enzyme Inhibitors; Male; Narcotic Antagonists; Pentazocine; Phenazocine; Phencyclidine; Propylamines; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa; Receptors, sigma; Sigma-1 Receptor | 2012 |
Fluvoxamine enhances prefrontal dopaminergic neurotransmission in adrenalectomized/castrated mice via both 5-HT reuptake inhibition and σ(1) receptor activation.
Topics: Adrenalectomy; Animals; Dopamine; Ethylenediamines; Fluvoxamine; Male; Mice; Mice, Inbred Strains; Norepinephrine; Orchiectomy; Phenazocine; Prefrontal Cortex; Receptors, Serotonin; Receptors, sigma; Selective Serotonin Reuptake Inhibitors; Serotonin; Sigma-1 Receptor; Synaptic Transmission | 2011 |
σ-1 Receptor agonist SKF10047 inhibits glutamate release in rat cerebral cortex nerve endings.
Topics: 4-Aminopyridine; Amino Acid Transport System X-AG; Animals; Aspartic Acid; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, N-Type; Cerebral Cortex; Cytosol; Glutamic Acid; Macrolides; Male; Membrane Potentials; Mitochondria; Nerve Endings; Phenazocine; Phosphorylation; Potassium Channel Blockers; Potassium Channels; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, sigma; Ryanodine Receptor Calcium Release Channel; Sigma-1 Receptor; Sodium-Calcium Exchanger; Vesicular Transport Proteins | 2012 |
Inhibitory effects of sigma-1 ligands on handling-induced tachycardia in conscious tethered rats.
Topics: Animals; Anisoles; Blood Pressure; Consciousness; Diazepam; Heart Rate; Ligands; Male; Phenazocine; Propylamines; Rats; Rats, Sprague-Dawley; Receptors, sigma; Sigma-1 Receptor; Tachycardia | 2013 |
Effects of (+) SKF 10,047, a sigma-1 receptor agonist, on anxiety,tested in two laboratory models in mice.
Topics: Animals; Anxiety; Disease Models, Animal; Exploratory Behavior; Male; Mice; Phenazocine; Random Allocation; Receptors, sigma; Single-Blind Method; Social Behavior | 2012 |
Inhibition of tumor cell growth by Sigma1 ligand mediated translational repression.
Topics: Cell Line, Tumor; Cell Proliferation; Cell Size; Haloperidol; Humans; Ligands; Morpholines; Neoplasms; Phenazocine; Protein Biosynthesis; Receptors, sigma; RNA Cap-Binding Proteins; Sigma-1 Receptor | 2012 |
Straub tail reaction in mice treated with σ(1) receptor antagonist in combination with methamphetamine.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Antipsychotic Agents; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Combinations; Male; Methamphetamine; Mice; Mice, Inbred Strains; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Phenazocine; Pyrimidines; Receptors, Opioid, delta; Reflex; Tail; Time Factors | 2012 |
Sigma-1 receptor agonists directly inhibit Nav1.2/1.4 channels.
Topics: Animals; Chlorocebus aethiops; COS Cells; Cyclic AMP-Dependent Protein Kinases; Dextromethorphan; GTP-Binding Proteins; Guanidines; HEK293 Cells; Humans; Ion Channel Gating; Lidocaine; Muscle Proteins; Mutagenesis, Site-Directed; Mutant Proteins; Mutation; NAV1.2 Voltage-Gated Sodium Channel; Neurons; Phenazocine; Protein Kinase C; Protein Kinase Inhibitors; Rats; Receptors, sigma; Sigma-1 Receptor; Signal Transduction; Sodium Channels; Transfection | 2012 |
Sigma-1 receptor stimulation attenuates calcium influx through activated L-type Voltage Gated Calcium Channels in purified retinal ganglion cells.
Topics: Animals; Animals, Newborn; Blotting, Western; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Signaling; Cells, Cultured; Ethylenediamines; Fluorescent Antibody Technique, Indirect; Fura-2; Microscopy, Fluorescence; Pentazocine; Phenazocine; Rats; Rats, Sprague-Dawley; Receptors, sigma; Retinal Ganglion Cells; Sigma-1 Receptor; Verapamil | 2013 |
Synergistic effect of 5-HT1A and σ1 receptor activation on prefrontal dopaminergic transmission under circulating steroid deficiency.
Topics: Adrenalectomy; Animals; Castration; Dopamine; Drug Synergism; Male; Mice; Mice, Inbred Strains; Phenazocine; Prefrontal Cortex; Proto-Oncogene Proteins c-fos; Receptor, Serotonin, 5-HT1A; Receptors, sigma; Serotonin Agents; Sigma-1 Receptor; Steroids; Ventral Tegmental Area | 2013 |
NMDA receptors are upregulated and trafficked to the plasma membrane after sigma-1 receptor activation in the rat hippocampus.
Topics: Animals; Cell Membrane; Disks Large Homolog 4 Protein; Ethylenediamines; Hippocampus; Intracellular Signaling Peptides and Proteins; Male; Membrane Proteins; Mice; Mice, Knockout; Morpholines; Pentazocine; Phenazocine; Piperazines; Protein Transport; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Sigma-1 Receptor; Subcellular Fractions; Time Factors; Up-Regulation | 2014 |
Allosteric Modulation of Sigma-1 Receptors Elicits Rapid Antidepressant Activity.
Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Anxiety; Benzazepines; Brain-Derived Neurotrophic Factor; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Embryo, Mammalian; Enzyme Inhibitors; Gene Expression Regulation; Hippocampus; Immobility Response, Tonic; Male; Mice; Mice, Inbred C57BL; Neurons; Phenazocine; Receptors, sigma; Sigma-1 Receptor; Signal Transduction; Stress, Psychological; Swimming; Time Factors; Venlafaxine Hydrochloride | 2016 |
Effects of the psychotomimetic benzomorphan N-allylnormetazocine (SKF 10,047) on prepulse inhibition of startle in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Anisoles; Dose-Response Relationship, Drug; Hallucinogens; Male; Mice; Mice, Inbred C57BL; Naltrexone; Phenazocine; Prepulse Inhibition; Propylamines; Receptors, Opioid, kappa; Receptors, Phencyclidine; Receptors, sigma; Reflex, Startle; Sigma-1 Receptor; Stereoisomerism | 2016 |
Involvement of GABAA receptors in 5-HT1A and σ1 receptor synergism on prefrontal dopaminergic transmission under circulating neurosteroid deficiency.
Topics: Adrenalectomy; Animals; Antipsychotic Agents; Castration; Diazepam; Dioxanes; Dioxoles; Dopamine; Fluvoxamine; GABA Antagonists; GABA Modulators; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Male; Mice; Norepinephrine; Nucleus Accumbens; Orchiectomy; Phenazocine; Picrotoxin; Prefrontal Cortex; Proto-Oncogene Proteins c-fos; Receptor, Serotonin, 5-HT1A; Receptors, GABA; Receptors, GABA-A; Receptors, sigma; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin 5-HT1 Receptor Agonists; Sigma-1 Receptor; Synaptic Transmission; Ventral Tegmental Area | 2016 |
Activation of the sigma receptor 1 modulates AMPA receptor-mediated light-evoked excitatory postsynaptic currents in rat retinal ganglion cells.
Topics: Animals; Calcium; Carbazoles; Cells, Cultured; Central Nervous System Agents; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethylenediamines; Excitatory Postsynaptic Potentials; Glutamic Acid; Light; Male; Patch-Clamp Techniques; Phenazocine; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, sigma; Retinal Ganglion Cells; Tissue Culture Techniques; Vision, Ocular; Voltage-Sensitive Dye Imaging | 2016 |
SKF-10047, a prototype Sigma-1 receptor agonist, augmented the membrane trafficking and uptake activity of the serotonin transporter and its C-terminus-deleted mutant via a Sigma-1 receptor-independent mechanism.
Topics: Animals; Cell Membrane; Chlorocebus aethiops; COS Cells; Endoplasmic Reticulum Stress; Gene Knockdown Techniques; Mutation; Phenazocine; Protein Transport; Receptors, sigma; Serotonin Plasma Membrane Transport Proteins; Sigma-1 Receptor | 2019 |
Pharmacological stimulation of sigma-1 receptor promotes activation of astrocyte via ERK1/2 and GSK3β signaling pathway.
Topics: Animals; Astrocytes; Cell Movement; Cell Proliferation; Cells, Cultured; Gene Knockdown Techniques; Glial Fibrillary Acidic Protein; Glycogen Synthase Kinase 3 beta; MAP Kinase Signaling System; Mice, Inbred C57BL; Phenazocine; Phosphorylation; Primary Cell Culture; Receptors, sigma; Sigma-1 Receptor; Signal Transduction | 2019 |
The sigma-1 receptor behaves as an atypical auxiliary subunit to modulate the functional characteristics of Kv1.2 channels expressed in HEK293 cells.
Topics: Cells, Cultured; Electrophysiological Phenomena; HEK293 Cells; Humans; Ion Channel Gating; Kv1.2 Potassium Channel; Patch-Clamp Techniques; Phenazocine; Receptors, sigma; Shaker Superfamily of Potassium Channels; Sigma-1 Receptor | 2019 |
Sigma-1 receptor regulates mitophagy in dopaminergic neurons and contributes to dopaminergic protection.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Autophagy-Related Protein-1 Homolog; Cell Line; Dopaminergic Neurons; Gene Knockdown Techniques; Mice; Mitochondria; Mitophagy; Morpholines; Parkinsonian Disorders; Pars Compacta; Phenazocine; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Protein Stability; Protein Transport; Receptors, sigma; Sigma-1 Receptor; Signal Transduction; Substantia Nigra; Ubiquitin; Ubiquitin-Protein Ligases | 2021 |
Sigma-1 Receptor Activation Suppresses Microglia M1 Polarization via Regulating Endoplasmic Reticulum-Mitochondria Contact and Mitochondrial Functions in Stress-Induced Hypertension Rats.
Topics: Animals; Blood Pressure; Calcium; Cell Polarity; Electroshock; Endoplasmic Reticulum; Heart Rate; Hypertension; Microglia; Mitochondria; Phenazocine; Rats; Receptors, sigma; Sigma-1 Receptor; Sympathetic Nervous System | 2021 |