pf-429242 and fatostatin

pf-429242 has been researched along with fatostatin* in 2 studies

Other Studies

2 other study(ies) available for pf-429242 and fatostatin

Article	Year
Sterol regulatory element-binding protein 1 inhibitors decrease pancreatic cancer cell viability and proliferation. Biochemical and biophysical research communications, 2017, 06-17, Volume: 488, Issue:1 Sterol regulatory element-binding protein1 (SREBP1) is a key regulatory factor that controls lipid homeostasis. Overactivation of SREBP1 and elevated lipid biogenesis are considered the major characteristics in malignancies of prostate cancer, endometrial cancer, and glioblastoma. However, the impact of SREBP1 activation in the progression of pancreatic cancer has not been explored. The present study examines the effect of suppression of SREBP1 activation by its inhibitors like fatostatin and PF429242 besides analyzing the impact of inhibitory effects on SREBP1 downstream signaling cascade such as fatty acid synthase (FAS), hydroxymethylglutaryl-CoA reductase (HMGCoAR), stearoyl-CoA desaturase-1 (SCD-1), and tumor suppressor protein p53 in MIA PaCa-2 pancreatic cancer cells. Both fatostatin and PF429242 inhibited the growth of MIA PaCa-2 cells in a time and concentration-dependent manner with maximal inhibition attained at 72 h time period with IC Topics: Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Humans; Pancreatic Neoplasms; Pyridines; Pyrrolidines; Sterol Regulatory Element Binding Protein 1; Structure-Activity Relationship; Thiazoles	2017
Antiviral Activity of Nordihydroguaiaretic Acid and Its Derivative Tetra- Antimicrobial agents and chemotherapy, 2017, Volume: 61, Issue:8 Flaviviruses are positive-strand RNA viruses distributed all over the world that infect millions of people every year and for which no specific antiviral agents have been approved. These viruses include the mosquito-borne West Nile virus (WNV), which is responsible for outbreaks of meningitis and encephalitis. Considering that nordihydroguaiaretic acid (NDGA) has been previously shown to inhibit the multiplication of the related dengue virus and hepatitis C virus, we have evaluated the effect of NDGA, and its methylated derivative tetra- Topics: Animals; Antiviral Agents; Cell Line; Chlorocebus aethiops; HeLa Cells; Humans; Lipid Metabolism; Masoprocol; Pyridines; Pyrrolidines; Sterol Regulatory Element Binding Proteins; Thiazoles; Vero Cells; Virus Replication; West Nile Fever; West Nile virus; Zika Virus; Zika Virus Infection	2017

Article

Year

Sterol regulatory element-binding protein 1 inhibitors decrease pancreatic cancer cell viability and proliferation.

Biochemical and biophysical research communications, 2017, 06-17, Volume: 488, Issue:1

Sterol regulatory element-binding protein1 (SREBP1) is a key regulatory factor that controls lipid homeostasis. Overactivation of SREBP1 and elevated lipid biogenesis are considered the major characteristics in malignancies of prostate cancer, endometrial cancer, and glioblastoma. However, the impact of SREBP1 activation in the progression of pancreatic cancer has not been explored. The present study examines the effect of suppression of SREBP1 activation by its inhibitors like fatostatin and PF429242 besides analyzing the impact of inhibitory effects on SREBP1 downstream signaling cascade such as fatty acid synthase (FAS), hydroxymethylglutaryl-CoA reductase (HMGCoAR), stearoyl-CoA desaturase-1 (SCD-1), and tumor suppressor protein p53 in MIA PaCa-2 pancreatic cancer cells. Both fatostatin and PF429242 inhibited the growth of MIA PaCa-2 cells in a time and concentration-dependent manner with maximal inhibition attained at 72 h time period with IC

Topics: Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Humans; Pancreatic Neoplasms; Pyridines; Pyrrolidines; Sterol Regulatory Element Binding Protein 1; Structure-Activity Relationship; Thiazoles

2017

Antiviral Activity of Nordihydroguaiaretic Acid and Its Derivative Tetra-

Antimicrobial agents and chemotherapy, 2017, Volume: 61, Issue:8

Flaviviruses are positive-strand RNA viruses distributed all over the world that infect millions of people every year and for which no specific antiviral agents have been approved. These viruses include the mosquito-borne West Nile virus (WNV), which is responsible for outbreaks of meningitis and encephalitis. Considering that nordihydroguaiaretic acid (NDGA) has been previously shown to inhibit the multiplication of the related dengue virus and hepatitis C virus, we have evaluated the effect of NDGA, and its methylated derivative tetra-

Topics: Animals; Antiviral Agents; Cell Line; Chlorocebus aethiops; HeLa Cells; Humans; Lipid Metabolism; Masoprocol; Pyridines; Pyrrolidines; Sterol Regulatory Element Binding Proteins; Thiazoles; Vero Cells; Virus Replication; West Nile Fever; West Nile virus; Zika Virus; Zika Virus Infection

2017