pf-3845 has been researched along with 1-6-bis(cyclohexyloximinocarbonyl)hexane* in 2 studies
2 other study(ies) available for pf-3845 and 1-6-bis(cyclohexyloximinocarbonyl)hexane
| Article | Year |
|---|---|
Fatty acid amide hydrolase (FAAH) inhibitor PF-3845 reduces viability, migration and invasiveness of human colon adenocarcinoma Colo-205 cell line: an in vitro study.
Earlier reports suggest that the endocannabinoids may play a role of endogenous tumor growth modulators. In this study, we investigated whether inhibition of the enzymes involved in the synthesis and degradation of endocannabinoids may reduce colorectal cancer cell invasion and migration. The human colon adenocarcinoma Colo-205 cells were incubated with PF-3845, JZL-184 and RHC-80267 (fatty acid amide hydrolase (FAAH), mono- (MAGL) and diacylglycerol lipase (DAGL) inhibitors, respectively) for 48 h. The MTT colorimetric assay was performed to quantify cell viability. Next, Colo-205 cells were incubated with PF-3845 alone or with PF-3845 together with selected antagonists: AM 251, AM 630, SB 366791, RN 1734 and G-15 (CB Topics: Adenocarcinoma; Amidohydrolases; Antineoplastic Agents; Benzodioxoles; Cell Line, Tumor; Cell Movement; Cell Survival; Colonic Neoplasms; Cyclohexanones; Enzyme Inhibitors; Humans; Piperidines; Pyridines; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2 | 2017 |
Modulation of the endocannabinoid system by the fatty acid amide hydrolase, monoacylglycerol and diacylglycerol lipase inhibitors as an attractive target for secretory diarrhoea therapy.
Secretory diarrhoea is a leading cause of mortality and morbidity worldwide. Our aim was to characterize the effect of inhibition of selected enzymes involved in the synthesis or degradation of endocannabinoids on electrolyte equilibrium in the mouse colonic tissue. The aim of this study was to evaluate the effects of PF-3845, JZL-184 and RHC-80267, as inhibitors of fatty acid amide hydrolase (FAAH), monoacylglycerol (MAGL) and diacylglycerol lipase (DAGL), respectively on epithelial ion transport in isolated mouse colon stimulated by forskolin (FSK), veratridine (VER) and bethanechol (BET). Next, colonic tissue was co-incubated with selected inhibitors and cannabinoid receptor antagonists: AM 251 and AM 630 (CB Topics: Amidohydrolases; Animals; Benzodioxoles; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cyclohexanones; Diarrhea; Endocannabinoids; Enzyme Inhibitors; Indoles; Lipoprotein Lipase; Male; Mice; Monoglycerides; Piperidines; Pyrazoles; Pyridines; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2 | 2017 |