Page last updated: 2024-08-20

perylene and pseudohypericin

perylene has been researched along with pseudohypericin in 68 studies

Research

Studies (68)

TimeframeStudies, this research(%)All Research%
pre-19903 (4.41)18.7374
1990's10 (14.71)18.2507
2000's33 (48.53)29.6817
2010's22 (32.35)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Akinaga, S; Kobayashi, E; Nakano, H; Suzuki, K; Takahashi, I; Tamaoki, T1
Colacino, JM; Larsen, SH; Spitzer, W; Tang, J1
Gallo, G; Lavie, D; Lavie, G; Levin, B; Mazur, Y; Meruelo, D; Valentine, F; Weiner, D1
Kobayashi, E; Nakanishi, S; Nakano, H; Suzuki, K; Takahashi, I; Tamaoki, T1
Lavie, D; Lavie, G; Meruelo, D1
Brockmöller, J; Kerb, R; Ploch, M; Roots, I; Staffeldt, B2
Bladt, S; Wagner, H1
Göbel, I; Heydel, B; Kartnig, T1
Lotz, R; Piperopoulos, G; Schmierer, T; Wixforth, A; Zeller, KP1
Bauer, S; Brockmöller, J; Hübner, WD; Kerb, R; Reum, T; Roots, I1
Butterweck, V; Nahrstedt, A; Petereit, F; Winterhoff, H1
de Witte, PA; Delaey, E; Himpens, BE; Kamuhabwa, A; Merlevede, WJ; Vandenbogaerde, AL1
Baraldi, M; De Witte, P; Kamuhabwa, A; Merlevede, W; Puia, G; Truzzi, C; Vandenbogaerde, A; Zanoli, P1
Draves, AH; Walker, SE2
Meier, B; Sticher, O; Wirz, A1
Di Gregorio, F; Girardin, P; Poutaraud, A; Tin, VC1
Chatterjee, S; Nöldner, M1
Bauer, S; Graubaum, HJ; Roots, I; Störmer, E1
Schempp, CM; Simon, JC; Simon-Haarhaus, B1
Djordjevic, S; Laatsch, H; Lepojevic, Z; Smelcerovic, A1
Carpenter, S; Chowdhury, P; Kesavan, S; Kraus, GA; Park, J; Petrich, JW; Wannemuehler, Y; Wen, J; Wills, NJ1
Murch, SJ; Rupasinghe, HP; Saxena, PK1
Berger Büter, K; Bobirnac, I; Lübbert, H; Schaffner, W; Schoeffter, P; Simmen, U; Ullmer, C1
Fu, MH; Huang, LQ; Li, GF; Te, HC; Xu, MS1
Bauer, S; Brockmöller, J; Johne, A; Mai, I; Perloff, ES; Roots, I; Schmider, J1
Gadzovska, S; Hagège, D; Joseph, C; Kascakova, S; Maury, S; Ounnar, S; Refregiers, M; Righezza, M; Spasenoski, M1
Fiamegos, YC; Gioti, EM; Skalkos, DC; Stalikas, CD1
Bässler, D; Schulz, HU; Schürer, M; Weiser, D2
Avery, BA; Shah, AK; Wyandt, CM1
Girard, J; Sander, LC; Williams, FB; Wise, SA1
Chessa, M; Pintore, G; Ricci, A; Sighinolfi, S; Tirillini, B1
Schubert-Zsilavecz, M; Wurglics, M1
Exner, M; Gmeiner, BM; Hermann, M; Kapiotis, S; Laggner, H; Mühl, A; Schreier, S1
Bornancin, A; Della Loggia, R; Morazzoni, P; Pace, R; Riva, A; Sosa, S; Tubaro, A1
Birt, DF; Delate, K; Dixon, PM; Hammer, KD; Hillwig, ML; Murphy, PA; Solco, AK; Wurtele, ES1
Exarchou, V; Gerothanassis, IP; Tatsis, EC; Troganis, AN1
Contartese, G; Couladis, M; Galati, EM; Lanuzza, F; Miceli, N; Sdrafkakis, V; Taviano, MF; Tzakou, O1
Birt, DF; Hammer, KD; Hillwig, ML; Kohut, ML; Neighbors, JD; Sim, YJ; Wiemer, DF; Wurtele, ES1
Cirak, C; Ivanauskas, L; Janulis, V; Radusiene, J3
Ayan, AK; Cirak, C1
Bilia, AR; Karioti, A; Vincieri, FF1
Bicker, W; Ciogli, A; Lindner, W1
Borsch, T; Kusari, S; Spiteller, M; Zühlke, S1
Bilia, AR; Karioti, A1
Kisselev, P; Roots, I; Schunck, WH; Schwarz, D1
Mielcarek, S; Turnau, K; Zubek, S1
Hatano, T; Inoue, R; Ito, H; Ochi, M; Onoue, S; Seto, Y; Yamada, S1
Boevé, JL; Crockett, SL1
Birt, DF; Hauck, C; Huang, N; Murphy, PA; Nikolau, BJ; Rizshsky, L1
Birt, DF; Hauck, CC; Huang, N; Murphy, PA; Nikolau, BJ; Rizshsky, L1
Miller, CD; Mortensen, T; Shen, F; Shen, S; Sims, RC; Walsh, MK1
Baptista, J; Fernandes-Ferreira, M; Lima, E; Rainha, N1
Algar, E; Mañero, FJ; Martín Gómez, MS; Saco Sierra, MD; Solano, BR1
Chimirri, S; Ciriaco, M; De Sarro, G; Esposito, S; Mammì, M; Mazzitello, C; Palleria, C; Patanè, M; Pugliese, M; Russo, E; Scicchitano, F; Upton, R; Whalley, BJ1
Birt, DF; Hammer, KD1
Cvejić, J; Goločorbin-Kon, S; Mikov, M; Mimica-Dukić, N; Rašković, A; Stilinović, N; Vukmirović, S1
Hou, Y; Li, D; Li, S; Li, Z; Qin, C; Sun, J1
Arakawa, NS; Cardoso, RD; Casagrande, R; Fattori, V; Hohmann, MS; Lopes, NP; Tomaz, JC; Verri, WA1
Avramescu, S; Branger, C; Florea, AM; Ghiurea, M; Hubca, G; Iordache, TV; Sârbu, A1
Čellárová, E; Janfelt, C; Kimáková, K; Kucharíková, A1
Jiang, Y; Kou, J; Li, H; Li, X; Liu, Z; Shao, Q; Tian, Y; Wu, J; Yang, L; Zheng, X; Zhong, Z; Zhu, X1
Carrubba, A; Lazzara, S; Militello, M; Napoli, E; Saia, S1
Burd, MA; Peterson, DG; Strong, ME1

Reviews

4 review(s) available for perylene and pseudohypericin

ArticleYear
Hypericum perforatum: a 'modern' herbal antidepressant: pharmacokinetics of active ingredients.
    Clinical pharmacokinetics, 2006, Volume: 45, Issue:5

    Topics: Animals; Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Clinical Trials as Topic; Depression; Flavonoids; Humans; Hypericum; Perylene; Phloroglucinol; Phytotherapy; Plant Extracts; Terpenes

2006
Hypericins as potential leads for new therapeutics.
    International journal of molecular sciences, 2010, Feb-04, Volume: 11, Issue:2

    Topics: Anthracenes; Anti-Infective Agents; Antidepressive Agents; Cell Survival; Humans; Hypericum; Neoplasms; Perylene; Photochemotherapy; Photosensitizing Agents

2010
Hypericum perforatum: pharmacokinetic, mechanism of action, tolerability, and clinical drug-drug interactions.
    Phytotherapy research : PTR, 2014, Volume: 28, Issue:5

    Topics: Anthracenes; Antidepressive Agents; Antiviral Agents; Depression; Herb-Drug Interactions; Humans; Hypericum; Perylene; Phloroglucinol; Plant Extracts; Plants, Medicinal; Terpenes

2014
Evidence for contributions of interactions of constituents to the anti-inflammatory activity of Hypericum perforatum.
    Critical reviews in food science and nutrition, 2014, Volume: 54, Issue:6

    Topics: Animals; Anti-Inflammatory Agents; Biflavonoids; Disease Models, Animal; Flavonoids; Humans; Hypericum; Perylene; Phloroglucinol; Plant Extracts; Signal Transduction; Terpenes

2014

Trials

6 trial(s) available for perylene and pseudohypericin

ArticleYear
Pharmacokinetics of hypericin and pseudohypericin after oral intake of the hypericum perforatum extract LI 160 in healthy volunteers.
    Journal of geriatric psychiatry and neurology, 1994, Volume: 7 Suppl 1

    Topics: Administration, Oral; Adult; Anthracenes; Antidepressive Agents; Chromatography, High Pressure Liquid; Double-Blind Method; Humans; Hypericum; Male; Perylene; Plant Extracts; Plants, Medicinal; Quercetin; Reference Values; Regression Analysis; Xanthenes

1994
Single-dose and steady-state pharmacokinetics of hypericin and pseudohypericin.
    Antimicrobial agents and chemotherapy, 1996, Volume: 40, Issue:9

    Topics: Administration, Oral; Adult; Anthracenes; Antiviral Agents; Area Under Curve; Body Weight; Chromatography, High Pressure Liquid; Double-Blind Method; Half-Life; Humans; Injections, Intravenous; Male; Perylene

1996
Hypericin and pseudohypericin: pharmacokinetics and effects on photosensitivity in humans.
    Pharmacopsychiatry, 1997, Volume: 30 Suppl 2

    Topics: Adult; Anthracenes; Antidepressive Agents; Cross-Over Studies; Double-Blind Method; Enzyme Inhibitors; Erythema; Female; Humans; Male; Perylene; Photosensitivity Disorders

1997
Impact of cytochrome P-450 inhibition by cimetidine and induction by carbamazepine on the kinetics of hypericin and pseudohypericin in healthy volunteers.
    European journal of clinical pharmacology, 2004, Volume: 60, Issue:9

    Topics: Adult; Anthracenes; Antidepressive Agents; Area Under Curve; Carbamazepine; Chromatography, High Pressure Liquid; Cimetidine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Double-Blind Method; Drug Interactions; Enzyme Inhibitors; Humans; Hypericum; Perylene; Time Factors

2004
Investigation of pharmacokinetic data of hypericin, pseudohypericin, hyperforin and the flavonoids quercetin and isorhamnetin revealed from single and multiple oral dose studies with a hypericum extract containing tablet in healthy male volunteers.
    Arzneimittel-Forschung, 2005, Volume: 55, Issue:10

    Topics: Adolescent; Adult; Anthracenes; Bridged Bicyclo Compounds; Flavonols; Humans; Hypericum; Male; Middle Aged; Perylene; Phloroglucinol; Plant Extracts; Quercetin; Tablets; Terpenes

2005
Investigation of the effect on photosensitivity following multiple oral dosing of two different hypericum extracts in healthy men.
    Arzneimittel-Forschung, 2006, Volume: 56, Issue:3

    Topics: Adolescent; Adult; Anthracenes; Erythema; Humans; Hypericum; Hypersensitivity; Light; Male; Middle Aged; Perylene; Plant Extracts; Skin

2006

Other Studies

58 other study(ies) available for perylene and pseudohypericin

ArticleYear
Calphostin (UCN1028) and calphostin related compounds, a new class of specific and potent inhibitors of protein kinase C.
    Advances in second messenger and phosphoprotein research, 1990, Volume: 24

    Topics: Animals; Anthracenes; Cell Division; Cell Line; Cladosporium; Humans; Mice; Molecular Structure; Naphthalenes; Perylene; Phorbol 12,13-Dibutyrate; Polycyclic Compounds; Protein Kinase C; Structure-Activity Relationship

1990
Virucidal activity of hypericin against enveloped and non-enveloped DNA and RNA viruses.
    Antiviral research, 1990, Volume: 13, Issue:6

    Topics: Animals; Anthracenes; Antiviral Agents; DNA Viruses; Encephalitis; Friend murine leukemia virus; Herpes Simplex; Leukemia, Experimental; Male; Mice; Mice, Inbred DBA; Perylene; RNA Viruses; RNA-Directed DNA Polymerase; Simplexvirus; Viral Envelope Proteins; Virus Activation

1990
Studies of the mechanisms of action of the antiretroviral agents hypericin and pseudohypericin.
    Proceedings of the National Academy of Sciences of the United States of America, 1989, Volume: 86, Issue:15

    Topics: Animals; Anthracenes; Antiviral Agents; Benz(a)Anthracenes; Cell Line; Friend murine leukemia virus; Leukemia, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Perylene; Retroviridae; Retroviridae Infections

1989
Hypericin and pseudohypericin specifically inhibit protein kinase C: possible relation to their antiretroviral activity.
    Biochemical and biophysical research communications, 1989, Dec-29, Volume: 165, Issue:3

    Topics: Animals; Anthracenes; Antiviral Agents; Benz(a)Anthracenes; Brain; Calpain; Cattle; Cells, Cultured; HIV; Mice; Mice, Inbred BALB C; Molecular Structure; Myocardium; Myosin-Light-Chain Kinase; Perylene; Phosphorylation; Protein Kinase C; Rats; Retroviridae

1989
Therapeutic agents with dramatic antiretroviral activity and little toxicity at effective doses: aromatic polycyclic diones hypericin and pseudohypericin.
    Proceedings of the National Academy of Sciences of the United States of America, 1988, Volume: 85, Issue:14

    Topics: Animals; Anthracenes; Antigens, Viral; Antiviral Agents; Benz(a)Anthracenes; Chemical Phenomena; Chemistry; Friend murine leukemia virus; Gene Expression Regulation; H-2 Antigens; Leukemia, Erythroblastic, Acute; Mice; Mice, Inbred Strains; Perylene; Retroviridae; Retroviridae Infections; RNA, Messenger; RNA, Viral

1988
Pharmaceutical quality of hypericum extracts.
    Journal of geriatric psychiatry and neurology, 1994, Volume: 7 Suppl 1

    Topics: Anthracenes; Antidepressive Agents; Hypericum; Molecular Structure; Perylene; Plant Extracts; Plants, Medicinal; Quercetin; Xanthenes

1994
Production of hypericin, pseudohypericin and flavonoids in cell cultures of various Hypericum species and their chemotypes.
    Planta medica, 1996, Volume: 62, Issue:1

    Topics: Animals; Anthracenes; Cells, Cultured; Flavonoids; Perylene; Plant Cells; Plants; Rats; Species Specificity

1996
Determination of naphthodianthrones in plant extracts from Hypericum perforatum L. by liquid chromatography-electrospray mass spectrometry.
    Journal of chromatography. B, Biomedical sciences and applications, 1997, Aug-01, Volume: 695, Issue:2

    Topics: Anthracenes; Chromatography, High Pressure Liquid; Mass Spectrometry; Perylene; Plant Extracts; Plants, Medicinal

1997
Solubilized hypericin and pseudohypericin from Hypericum perforatum exert antidepressant activity in the forced swimming test.
    Planta medica, 1998, Volume: 64, Issue:4

    Topics: Animals; Anthracenes; Antidepressive Agents; Male; Perylene; Rats; Solubility; Stress, Psychological; Swimming

1998
Photocytotoxic effect of pseudohypericin versus hypericin.
    Journal of photochemistry and photobiology. B, Biology, 1998, Volume: 45, Issue:2-3

    Topics: Anthracenes; Female; Fluorescence; Humans; Molecular Structure; Perylene; Photosensitivity Disorders; Subcellular Fractions; Tumor Cells, Cultured

1998
Evidence that total extract of Hypericum perforatum affects exploratory behavior and exerts anxiolytic effects in rats.
    Pharmacology, biochemistry, and behavior, 2000, Volume: 65, Issue:4

    Topics: Animals; Anthracenes; Anti-Anxiety Agents; Cerebellum; Electrophysiology; Exploratory Behavior; Flumazenil; GABA Modulators; GABA-A Receptor Antagonists; Hypericum; Male; Motor Activity; Patch-Clamp Techniques; Perylene; Plant Extracts; Plants, Medicinal; Rats; Rats, Sprague-Dawley; Receptors, GABA; Receptors, N-Methyl-D-Aspartate

2000
Determination of hypericin and pseudohypericin in pharmaceutical preparations by liquid chromatography with fluorescence detection.
    Journal of chromatography. B, Biomedical sciences and applications, 2000, Nov-10, Volume: 749, Issue:1

    Topics: Anthracenes; Chromatography, Liquid; Perylene; Pharmaceutical Preparations; Sensitivity and Specificity; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet

2000
Absorbance data of hypericin and pseudohypericin used as reference compounds for medicinal plant analysis.
    Die Pharmazie, 2001, Volume: 56, Issue:1

    Topics: Anthracenes; Chromatography, High Pressure Liquid; Perylene; Plants, Medicinal; Reference Standards; Solvents; Spectrophotometry, Ultraviolet

2001
Effect of light on hypericins contents in fresh flowering top parts and in an extract of St. John's Wort (Hypericum perforatum).
    Planta medica, 2001, Volume: 67, Issue:3

    Topics: Anthracenes; Antidepressive Agents; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Hypericum; Perylene; Pigments, Biological; Plant Extracts; Plant Leaves; Plant Stems; Plants, Medicinal; Sunlight

2001
Effects of two different extracts of St. John's wort and some of their constituents on cytochrome P450 activities in rat liver microsomes.
    Pharmacopsychiatry, 2001, Volume: 34 Suppl 1

    Topics: Animals; Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Cytochrome P-450 Enzyme System; Ethanol; Excitatory Amino Acid Antagonists; Female; Hypericum; Liver; Male; Methanol; Microsomes; Perylene; Phenobarbital; Phloroglucinol; Plant Extracts; Quercetin; Rats; Rats, Sprague-Dawley; Sex Factors; Solvents; Terpenes

2001
Determination of hyperforin, hypericin, and pseudohypericin in human plasma using high-performance liquid chromatography analysis with fluorescence and ultraviolet detection.
    Journal of chromatography. B, Biomedical sciences and applications, 2001, Dec-05, Volume: 765, Issue:1

    Topics: Anthracenes; Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Humans; Perylene; Phloroglucinol; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Terpenes

2001
Phototoxic and apoptosis-inducing capacity of pseudohypericin.
    Planta medica, 2002, Volume: 68, Issue:2

    Topics: Anthracenes; Apoptosis; Cell Division; DNA Fragmentation; Dose-Response Relationship, Drug; Humans; Hypericum; Jurkat Cells; Molecular Structure; Perylene

2002
The separation of hypericine and pseudohypericine from Hypericum perforatum L.
    Die Pharmazie, 2002, Volume: 57, Issue:3

    Topics: Anthracenes; Chromatography; Chromatography, Thin Layer; Countercurrent Distribution; Hypericum; Magnetic Resonance Spectroscopy; Methanol; Perylene; Solvents; Spectrophotometry, Ultraviolet; Ultrasonics

2002
Toward the molecular flashlight: preparation, properties, and photophysics of a hypericin-luciferin tethered molecule.
    Photochemistry and photobiology, 2002, Volume: 76, Issue:2

    Topics: Anthracenes; Firefly Luciferin; Perylene; Photochemistry; Photochemotherapy; Photosensitizing Agents

2002
An in vitro and hydroponic growing system for hypericin, pseudohypericin, and hyperforin production of St. John's wort (Hypericum perforatum CV new stem).
    Planta medica, 2002, Volume: 68, Issue:12

    Topics: Anthracenes; Bridged Bicyclo Compounds; Culture Techniques; Environment, Controlled; Hydroponics; Hypericum; Perylene; Phloroglucinol; Plant Extracts; Terpenes

2002
Antagonist effect of pseudohypericin at CRF1 receptors.
    European journal of pharmacology, 2003, Jan-05, Volume: 458, Issue:3

    Topics: Animals; Anthracenes; Bridged Bicyclo Compounds; Calcitonin; CHO Cells; Corticotropin-Releasing Hormone; Cricetinae; Cyclic AMP; Dose-Response Relationship, Drug; Humans; Perylene; Phloroglucinol; Receptors, Corticotropin-Releasing Hormone; Terpenes; Transfection

2003
[Induction of callus of Hypericum perforatum L. and qualitative identification of active constituents of its callus].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2001, Volume: 26, Issue:12

    Topics: Anthracenes; Culture Media; Culture Techniques; Hypericum; Perylene; Plant Leaves; Plants, Medicinal

2001
Analysis of the hypericin and pseudohypericin content of commercially available St John's Wort preparations.
    The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique, 2003,Fall, Volume: 10, Issue:3

    Topics: Anthracenes; Antidepressive Agents; Canada; Capsules; Chromatography, Liquid; Hypericum; Perylene; Spectrometry, Fluorescence; Tablets; United States

2003
Identification and quantification of hypericin and pseudohypericin in different Hypericum perforatum L. in vitro cultures.
    Plant physiology and biochemistry : PPB, 2005, Volume: 43, Issue:6

    Topics: Anthracenes; Chromatography, High Pressure Liquid; Culture Techniques; Hypericum; Perylene; Plant Growth Regulators

2005
Single-drop liquid-phase microextraction for the determination of hypericin, pseudohypericin and hyperforin in biological fluids by high performance liquid chromatography.
    Journal of chromatography. A, 2005, Nov-04, Volume: 1093, Issue:1-2

    Topics: Anthracenes; Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Hydrogen-Ion Concentration; Osmolar Concentration; Perylene; Phloroglucinol; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Terpenes

2005
Content analysis and stability evaluation of selected commercial preparations of St. John's wort.
    Drug development and industrial pharmacy, 2005, Volume: 31, Issue:9

    Topics: Anthracenes; Antidepressive Agents; Capsules; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Drug Stability; Environment; Hardness; Humidity; Hypericum; Indicators and Reagents; Perylene; Reference Standards; Reproducibility of Results; Solvents; Spectrophotometry, Ultraviolet; Tablets; Temperature

2005
Development and evaluation of methods for determination of naphthodianthrones and flavonoids in St. John's wort.
    Journal of chromatography. A, 2006, May-19, Volume: 1115, Issue:1-2

    Topics: Anthracenes; Chemical Fractionation; Chromatography, Liquid; Flavonoids; Hypericum; Mass Spectrometry; Perylene

2006
Induction of hypericins in Hypericum perforatum in response to chromium.
    Fitoterapia, 2006, Volume: 77, Issue:3

    Topics: Analysis of Variance; Anthracenes; Chromium; Gene Expression Regulation; Hypericum; Perylene; Plants, Medicinal; Seedlings

2006
The main components of St John's Wort inhibit low-density lipoprotein atherogenic modification: a beneficial "side effect" of an OTC antidepressant drug?
    Free radical research, 2007, Volume: 41, Issue:2

    Topics: Anthracenes; Antidepressive Agents; Antioxidants; Atherosclerosis; Bridged Bicyclo Compounds; Cells, Cultured; Chromatography, High Pressure Liquid; Circular Dichroism; Depression; Drug Evaluation, Preclinical; Endothelial Cells; Humans; Hypericum; Lipoproteins, LDL; Malondialdehyde; Mass Spectrometry; Molecular Structure; Nonprescription Drugs; Oxidation-Reduction; Peroxidase; Perylene; Phloroglucinol; Phytotherapy; Protein Binding; Structure-Activity Relationship; Terpenes; Thiobarbituric Acid Reactive Substances; Thromboplastin; Tyrosine; Umbilical Veins

2007
Topical anti-inflammatory activity of extracts and compounds from Hypericum perforatum L.
    The Journal of pharmacy and pharmacology, 2007, Volume: 59, Issue:5

    Topics: Administration, Topical; Animals; Anthracenes; Anti-Inflammatory Agents; Bridged Bicyclo Compounds; Croton Oil; Dose-Response Relationship, Drug; Edema; Flavonoids; Flowers; Hypericum; Inhibitory Concentration 50; Male; Mice; Perylene; Phloroglucinol; Phytotherapy; Plant Extracts; Plants, Medicinal; Terpenes

2007
Inhibition of prostaglandin E(2) production by anti-inflammatory hypericum perforatum extracts and constituents in RAW264.7 Mouse Macrophage Cells.
    Journal of agricultural and food chemistry, 2007, Sep-05, Volume: 55, Issue:18

    Topics: Animals; Anti-Inflammatory Agents; Bridged Bicyclo Compounds; Cell Death; Cells, Cultured; Dinoprostone; Flavonoids; Hypericum; Light; Macrophages; Mice; Perylene; Phloroglucinol; Plant Extracts; Terpenes

2007
1H NMR determination of hypericin and pseudohypericin in complex natural mixtures by the use of strongly deshielded OH groups.
    Analytica chimica acta, 2008, Jan-28, Volume: 607, Issue:2

    Topics: Anthracenes; Chromatography, Liquid; Hydrogen Bonding; Hypericum; Mass Spectrometry; Nuclear Magnetic Resonance, Biomolecular; Perylene; Plant Extracts; Spectrophotometry, Ultraviolet

2008
Antiinflammatory and antioxidant activity of Hypericum rumeliacum Boiss. subsp. apollinis (Boiss. & Heldr.) Robson & Strid methanol extract.
    Phytotherapy research : PTR, 2008, Volume: 22, Issue:6

    Topics: Animals; Anthracenes; Anti-Inflammatory Agents; Antioxidants; Chlorogenic Acid; Chondrus; Chromatography, High Pressure Liquid; Edema; Flavonoids; Hindlimb; Hypericum; Male; Methanol; Perylene; Phenols; Plant Components, Aerial; Plant Extracts; Polyphenols; Quercetin; Rats; Rats, Wistar; Rutin

2008
Pseudohypericin is necessary for the light-activated inhibition of prostaglandin E2 pathways by a 4 component system mimicking an Hypericum perforatum fraction.
    Phytochemistry, 2008, Volume: 69, Issue:12

    Topics: Animals; Cell Line; Chlorogenic Acid; Dinoprostone; Ethanol; Hypericum; Light; Macrophages; Mice; Perylene; Plant Extracts; Quercetin; Rutin

2008
Pseudohypericin and hyperforin in Hypericum perforatum from Northern Turkey: variation among populations, plant parts and phenological stages.
    Journal of integrative plant biology, 2008, Volume: 50, Issue:5

    Topics: Bridged Bicyclo Compounds; Climate; Geography; Hypericum; Perylene; Phloroglucinol; Plant Leaves; Plant Stems; Plant Structures; Population Dynamics; Seasons; Terpenes; Turkey

2008
Variation of hypericins in Hypericum triquetrifolium Turra growing in different locations of Turkey during plant growth.
    Natural product research, 2008, Volume: 22, Issue:18

    Topics: Anthracenes; Hypericum; Perylene; Plants, Medicinal; Turkey

2008
Rapid and efficient purification of naphthodianthrones from St. John's wort extract by using liquid-liquid extraction and SEC.
    Journal of separation science, 2009, Volume: 32, Issue:9

    Topics: Acetates; Anthracenes; Chromatography, Gel; Dextrans; Enzyme Inhibitors; Hexanes; Hypericum; Magnetic Resonance Spectroscopy; Mass Spectrometry; Methanol; Perylene; Plant Extracts; Solvents; Water

2009
Determination of enantiomerization barriers of hypericin and pseudohypericin by dynamic high-performance liquid chromatography on immobilized polysaccharide-type chiral stationary phases and off-column racemization experiments.
    Chirality, 2010, May-15, Volume: 22, Issue:5

    Topics: Anthracenes; Chromatography, High Pressure Liquid; Perylene; Polysaccharides; Stereoisomerism; Teicoplanin

2010
Positive correlations between hypericin and putative precursors detected in the quantitative secondary metabolite spectrum of Hypericum.
    Phytochemistry, 2009, Volume: 70, Issue:10

    Topics: Anthracenes; Chromatography, Liquid; Discriminant Analysis; Emodin; Hypericum; Multivariate Analysis; Perylene; Principal Component Analysis; Tandem Mass Spectrometry

2009
Chemical constituents of Hypericum adenotrichum Spach, an endemic Turkish species.
    Natural product research, 2009, Volume: 23, Issue:13

    Topics: Anthracenes; Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Hypericum; Kaempferols; Perylene; Phloroglucinol; Quercetin; Terpenes; Turkey

2009
Secondary metabolites of Hypericum confertum and their possible chemotaxonomic significance.
    Natural product communications, 2010, Volume: 5, Issue:6

    Topics: Anthracenes; Apigenin; Biflavonoids; Bridged Bicyclo Compounds; Chlorogenic Acid; Hypericum; Perylene; Phloroglucinol; Plant Components, Aerial; Quercetin; Rutin; Terpenes

2010
Inhibition of 17β-estradiol activation by CYP1A1: genotype- and regioselective inhibition by St. John's Wort and several natural polyphenols.
    Biochimica et biophysica acta, 2011, Volume: 1814, Issue:1

    Topics: Amino Acid Substitution; Anthracenes; Anti-Inflammatory Agents, Non-Steroidal; Biocatalysis; Cytochrome P-450 CYP1A1; Dose-Response Relationship, Drug; Estradiol; Flavonoids; Flavonols; Genotype; Humans; Hydroxylation; Hypericum; Perylene; Phenols; Plant Extracts; Polyphenols; Quercetin; Recombinant Proteins; Resveratrol; Stereoisomerism; Stilbenes; Substrate Specificity

2011
Hypericin and pseudohypericin concentrations of a valuable medicinal plant Hypericum perforatum L. are enhanced by arbuscular mycorrhizal fungi.
    Mycorrhiza, 2012, Volume: 22, Issue:2

    Topics: Anthracenes; Glomeromycota; Hypericum; Mycorrhizae; Perylene; Plants, Medicinal

2012
In vitro photochemical and phototoxicological characterization of major constituents in St. John's Wort (Hypericum perforatum) extracts.
    Phytochemistry, 2011, Volume: 72, Issue:14-15

    Topics: Anthracenes; Antidepressive Agents; Biological Products; Dermatitis, Phototoxic; DNA Damage; Enzyme Inhibitors; Hypericum; Light; Lipid Peroxidation; Perylene; Phloroglucinol; Plant Extracts; Reactive Oxygen Species; Terpenes

2011
Flavonoid glycosides and naphthodianthrones in the sawfly Tenthredo zonula and its host-plants, Hypericum perforatum and H. hirsutum.
    Journal of chemical ecology, 2011, Volume: 37, Issue:9

    Topics: Animals; Anthracenes; Flavonoids; Glycosides; Host-Parasite Interactions; Hymenoptera; Hypericum; Larva; Perylene

2011
Identification of anti-inflammatory constituents in Hypericum perforatum and Hypericum gentianoides extracts using RAW 264.7 mouse macrophages.
    Phytochemistry, 2011, Volume: 72, Issue:16

    Topics: Animals; Anti-Inflammatory Agents; Cells, Cultured; Chemical Fractionation; Chromatography, Liquid; Dinoprostone; Hypericum; Macrophages; Mass Spectrometry; Mice; Nitric Oxide; Perylene; Plant Extracts

2011
The inhibition of lipopolysaccharide-induced macrophage inflammation by 4 compounds in Hypericum perforatum extract is partially dependent on the activation of SOCS3.
    Phytochemistry, 2012, Volume: 76

    Topics: Animals; Anti-Inflammatory Agents; Biflavonoids; Cell Line; Chlorogenic Acid; Cytokines; Dinoprostone; Ethanol; Gene Knockdown Techniques; Hypericum; Inflammation; Inflammation Mediators; Lipopolysaccharides; Macrophages; Mice; Nitric Oxide; Perylene; Quercetin; RNA, Small Interfering; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins; Transcription, Genetic; Transfection

2012
Investigating the effectiveness of St John's wort herb as an antimicrobial agent against mycobacteria.
    Phytotherapy research : PTR, 2012, Volume: 26, Issue:9

    Topics: Anthracenes; Anti-Bacterial Agents; Hypericum; Microbial Sensitivity Tests; Microscopy, Electron, Scanning; Mycobacterium; Perylene; Phloroglucinol; Plant Extracts; Terpenes

2012
Content of hypericins from plants and in vitro shoots of Hypericum undulatum Schousb. ex Willd.
    Natural product research, 2013, Volume: 27, Issue:10

    Topics: Anthracenes; Chromatography, High Pressure Liquid; Hypericum; Molecular Structure; Perylene; Plant Shoots

2013
Elicitation of secondary metabolism in Hypericum perforatum by rhizosphere bacteria and derived elicitors in seedlings and shoot cultures.
    Pharmaceutical biology, 2012, Volume: 50, Issue:10

    Topics: Anthracenes; Bacteria; Chromatography, High Pressure Liquid; Culture Media; Hypericum; Perylene; Plant Shoots; Rhizosphere; Seedlings; Tissue Culture Techniques

2012
Interaction between different extracts of Hypericum perforatum L. from Serbia and pentobarbital, diazepam and paracetamol.
    Molecules (Basel, Switzerland), 2014, Mar-28, Volume: 19, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anthracenes; Anti-Anxiety Agents; Capsules; Diazepam; Female; Herb-Drug Interactions; Hypericum; Male; Mice; Motor Activity; Pentobarbital; Perylene; Plant Extracts; Plants, Medicinal; Serbia; Solvents; Tablets

2014
Molecularly imprinted polymer for specific extraction of hypericin from Hypericum perforatum L. herbal extract.
    Journal of pharmaceutical and biomedical analysis, 2014, Volume: 98

    Topics: Acetone; Acrylamide; Acrylates; Adsorption; Anthracenes; Binding Sites; Chromatography, High Pressure Liquid; Herbal Medicine; Hydrogen Bonding; Hypericum; Liquid-Liquid Extraction; Molecular Imprinting; Perylene; Plant Extracts; Polymers; Propylene Glycols; Solid Phase Extraction

2014
Hypericum perforatum Reduces Paracetamol-Induced Hepatotoxicity and Lethality in Mice by Modulating Inflammation and Oxidative Stress.
    Phytotherapy research : PTR, 2015, Volume: 29, Issue:7

    Topics: Acetaminophen; Alanine Transaminase; Animals; Anthracenes; Anti-Inflammatory Agents; Antioxidants; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Glutathione; Hypericum; Inflammation; Male; Mice; Oxidative Stress; Perylene; Phloroglucinol; Plant Extracts; Plants, Medicinal; Quercetin; Rutin; Terpenes; Tumor Necrosis Factor-alpha

2015
An innovative approach to prepare hypericin molecularly imprinted pearls using a "phyto-template".
    Talanta, 2016, Volume: 148

    Topics: Anthracenes; Chromatography, High Pressure Liquid; Hypericum; Molecular Imprinting; Perylene; Plant Extracts; Solid Phase Extraction; Spectroscopy, Fourier Transform Infrared

2016
Interspecific variation in localization of hypericins and phloroglucinols in the genus Hypericum as revealed by desorption electrospray ionization mass spectrometry imaging.
    Physiologia plantarum, 2016, Volume: 157, Issue:1

    Topics: Anthracenes; Hypericum; Perylene; Phloroglucinol; Plant Leaves; Species Specificity; Spectrometry, Mass, Electrospray Ionization; Terpenes

2016
Apoptosis of THP-1 Macrophages Induced by Pseudohypericin-Mediated Sonodynamic Therapy Through the Mitochondria-Caspase Pathway.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2016, Volume: 38, Issue:2

    Topics: Apoptosis; Caspases; Cell Line; Cell Survival; Cytochromes c; Humans; Hypericum; Macrophages; Membrane Potential, Mitochondrial; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Perylene; Plaque, Atherosclerotic; Reactive Oxygen Species; Ultrasonic Therapy

2016
Arbuscular mycorrhizal fungi altered the hypericin, pseudohypericin, and hyperforin content in flowers of Hypericum perforatum grown under contrasting P availability in a highly organic substrate.
    Mycorrhiza, 2017, Volume: 27, Issue:4

    Topics: Anthracenes; Flowers; Hypericum; Mycorrhizae; Perylene; Phloroglucinol; Phosphorus; Plant Extracts; Terpenes

2017
Evaluation of the MA-10 cell line as a model of insl3 regulation and Leydig cell function.
    Animal reproduction science, 2019, Volume: 208

    Topics: Animals; Cell Line; Chorionic Gonadotropin; Flavonoids; Gene Expression Regulation; Insulin; Isoquinolines; Leydig Cells; Male; Mice; Nuclear Receptor Subfamily 4, Group A, Member 1; Perylene; Proteins; Signal Transduction; Sulfonamides; Testosterone; Wortmannin

2019