perylene has been researched along with hypericum in 292 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (0.34) | 18.7374 |
| 1990's | 59 (20.21) | 18.2507 |
| 2000's | 139 (47.60) | 29.6817 |
| 2010's | 82 (28.08) | 24.3611 |
| 2020's | 11 (3.77) | 2.80 |
| Authors | Studies |
|---|---|
| Hübner, WD; Lande, S; Podzuweit, H | 1 |
| Hänsgen, KD; Ploch, M; Vesper, J | 1 |
| Arnoldt, KH; Hübner, WD; Vorbach, EU | 2 |
| Harrer, G; Hübner, WD; Podzuweit, H | 1 |
| Kasper, S; Martinez, B; Möller, HJ; Ruhrmann, S | 1 |
| Burkard, G; Grünwald, J; Woelk, H | 1 |
| Jobert, M; Schulz, H | 1 |
| Frauendorf, A; Johnson, D; Ksciuk, H; Sauerwein-Giese, E; Woelk, H | 1 |
| Brockmöller, J; Kerb, R; Ploch, M; Roots, I; Staffeldt, B | 1 |
| Thiede, HM; Walper, A | 1 |
| Bladt, S; Wagner, H | 2 |
| Harrer, G; Schulz, V | 1 |
| Brink, I; Ploch, M; Thiele, B | 1 |
| Müller, WE; Rossol, R | 1 |
| Harrer, G; Sommer, H | 1 |
| De Smet, PA; Nolen, WA | 1 |
| Linde, K; Melchart, D; Mulrow, CD; Pauls, A; Ramirez, G; Weidenhammer, W | 1 |
| Müller, WE; Perovic, S | 1 |
| Kasper, S | 2 |
| Brockow, K; Golsch, S; Rakoski, J; Ring, J; Vocks, E | 1 |
| Rampes, H | 1 |
| Volz, HP | 1 |
| Wheatley, D | 1 |
| Czekalla, J; Gastpar, M; Hübner, WD; Jäger, D | 1 |
| Hafner, U; Müller, WE; Rolli, M; Schäfer, C | 1 |
| Cott, JM | 1 |
| Gleitz, J; Teufel-Mayer, R | 1 |
| Dimpfel, W; Schombert, L | 1 |
| Dimpfel, W; Hofmann, R | 1 |
| Adler, M | 1 |
| Joraschky, P; Moesler, T; Mueck-Weymann, M; Rechlin, T; Tritt, K | 1 |
| Nierenberg, A | 1 |
| Myers, J | 1 |
| Miller, AL | 1 |
| Bowman, MA; Nicklin, DE | 1 |
| Guenther, G; Heiligenstein, E | 1 |
| Chatterjee, SS; Erdelmeier, C; Koch, E; Nöldner, M | 1 |
| Hafner, U; Müller, WE; Rolli, M; Schäfer, C; Singer, A; Wonnemann, M | 1 |
| Bhattacharya, SK; Chakrabarti, A; Chatterjee, SS | 1 |
| Dimpfel, W; Mannel, M; Schober, F | 1 |
| Biber, A; Chatterjee, SS; Fischer, H; Römer, A | 1 |
| Dimpfel, W; Sauer, S; Schellenberg, R | 1 |
| Baghai, T; Kieser, M; Laakmann, G; Schüle, C | 1 |
| McIntyre, RV | 1 |
| Cott, JM; Fugh-Berman, A | 1 |
| Bhattacharya, SK; Chatterjee, SS; Müller, WE; Singer, A; Wonnemann, M | 1 |
| Bu, Y; Neary, JT | 1 |
| Bernd, A; Diaz Alperi, J; Kaufmann, R; Kippenberger, S; Miquel, J; Pamies Mira, D; Ramirez Bosca, A; Simon, S; Villalba Garcia, JF | 1 |
| Chan, PJ; King, A; Ondrizek, RR; Patton, WC | 1 |
| Augustijns, P; de Witte, PA; Kamuhabwa, AR | 1 |
| Charchoglyan, A; Hayashi, H; Inoue, K; Kirakosyan, A; Vardapetyan, H | 1 |
| Baraldi, M; De Witte, P; Kamuhabwa, A; Merlevede, W; Puia, G; Truzzi, C; Vandenbogaerde, A; Zanoli, P | 1 |
| Denke, A; Elstner, EF; Schempp, H; Weiser, D | 1 |
| Obach, RS | 1 |
| Lüdtke, R; Schempp, CM; Simon, JC; Winghofer, B | 1 |
| Chignell, CF; Datillo, M; Patat, S; Roberts, JE; Schey, KL; Wang, RH | 1 |
| Agostini, M; Chatterjee, VK; Love, J; Schwabe, JW; Wentworth, JM | 1 |
| Carnat, A; Carnat, AP; Fraisse, D; Girzu-Amblard, M; Lamaison, JL | 1 |
| Agrosi, M; Harrasser, PC; Mischiatti, S; Savio, D | 1 |
| Chi, JD; Cowen, PJ; Franklin, M; Mannel, M | 1 |
| Bourke, CA; Southwell, IA | 1 |
| Müller, K; Schempp, CM; Schulte-Mönting, J; Simon, JC; Winghofer, B | 1 |
| Schulz, V | 1 |
| Di Gregorio, F; Girardin, P; Poutaraud, A; Tin, VC | 1 |
| Hunt, EJ; Lester, CE; Lester, EA; Tackett, RL | 1 |
| Chatterjee, S; Nöldner, M | 1 |
| Müller, WE; Siebert, B; Singer, A; Wonnemann, M | 1 |
| Baumeister, A; Dressman, J; Kaunzinger, A; Schubert-Zsilovecz, M; Westerhoff, K; Wilke, A; Wurglics, M | 1 |
| Butterweck, V; Korte, B; Winterhoff, H | 1 |
| Cowen, PJ; Franklin, M | 1 |
| Gobbi, M; Mennini, T; Moia, M; Morizzoni, P; Pirona, L | 1 |
| Calapai, G; Caputi, AP; Ciliberto, G; Crupi, A; De Sarro, G; Firenzuoli, F; Inferrera, G; Parisi, A | 1 |
| Butterweck, V; Herkenham, M; Winterhoff, H | 1 |
| Bergonzi, MC; Bilia, AR; Gallori, S; Guerrini, D; Vincieri, FF | 1 |
| Taylor, D; Werneke, U; Whiskey, E | 1 |
| Baker, RK; Kroll, DJ; Kurz, EU; Peebles, KA; Schneider, BJ | 1 |
| de los Reyes, GC; Koda, RT | 2 |
| Coutts, RT; Gu, LD; Ling, L; Pang, PK; Shan, JJ; Sloley, BD; Urichuk, LJ | 1 |
| Hansen, SH; Jensen, AG | 1 |
| Greenblatt, DJ; Perloff, MD; Shader, RI; Störmer, E; von Moltke, LL | 1 |
| Kiniczky, M | 1 |
| Mrlianová, M; Tekel'ová, D | 1 |
| Agostinis, P; de Witte, PA; Merlevede, W; Vantieghem, A | 1 |
| Schempp, CM; Simon, JC; Simon-Haarhaus, B | 1 |
| Böckers, T; Butterweck, V; Korte, B; Winterhoff, H; Wittkowski, W | 1 |
| Bray, BJ; Brennan, NJ; Menkes, DB; Perry, NB; Rosengren, RJ | 1 |
| Djordjevic, S; Laatsch, H; Lepojevic, Z; Smelcerovic, A | 1 |
| Cotterill, JA | 1 |
| Pal Bais, H; Vivanco, JM; Walker, TS | 1 |
| Bonn, GK; Huck, CW; Pirker, R | 1 |
| Murch, SJ; Rupasinghe, HP; Saxena, PK | 1 |
| Abourashed, EA; Glisson, JK; Hufford, CD; Khan, I; Ogletree, R; Rogers, HE | 1 |
| Schmitt, J | 1 |
| Hershey, CM; Lammering, GM; Taher, MM; Valerie, KC | 1 |
| Jürgenliemk, G; Nahrstedt, A | 1 |
| Butterweck, V; Christoffel, V; Nahrstedt, A; Petereit, F; Spengler, B; Winterhoff, H | 1 |
| Fu, MH; Huang, LQ; Li, GF; Te, HC; Xu, MS | 1 |
| Schmidt, PC | 1 |
| Bais, HP; Lawrence, CB; Stermitz, FR; Vepachedu, R; Vivanco, JM | 1 |
| Bommer, S; Hostanska, K; Reichling, J; Saller, R; Weber, M | 1 |
| HAGENSTROM, U; NEUWALD, F | 1 |
| Draves, AH; Walker, SE | 1 |
| Gibson, DM; Kaufman, PB; Kirakosyan, A; Sirvent, TM | 1 |
| Butterweck, V; Simbrey, K; Winterhoff, H | 1 |
| Bonmassar, E; Comandini, A; Franzese, O; Roscetti, G | 1 |
| Bini Maleci, L; Borsarini, A; Caniato, R; Cappelletti, EM; Filippini, R; Piovan, A | 1 |
| Gibson, DM; Krasnoff, SB; Sirvent, TM | 1 |
| Barecki-Roach, M; Johnson, WW; Wang, EJ | 1 |
| Al-Eleimat, T; Alali, F; Tawaha, K | 1 |
| Gobbi, M; Mennini, T | 1 |
| Borrelli, F; Capasso, F; Capasso, R; Izzo, AA; Mascolo, N | 1 |
| Bernatoniene, J; Ramanauskiene, K; Savickas, A | 1 |
| Bauer, S; Brockmöller, J; Johne, A; Mai, I; Perloff, ES; Roots, I; Schmider, J | 1 |
| Burhenne, J; Haefeli, WE; Martin-Facklam, M; Riedel, KD; Rieger, K; Walter-Sack, I | 1 |
| Bagdonaite, E; Kazlauskas, S | 1 |
| Goldstein, DS; Haertter, S; Jordan, J; Luft, FC; Schroeder, C; Stoeter, M; Tank, J | 1 |
| Chen, ML; Fu, MH; Huang, LQ; Luo, YM; Yang, B | 1 |
| Chen, ML; Huang, LQ; Li, GF; Xu, MS; Ye, HC | 1 |
| Koyabu, N; Morimoto, S; Ohtani, H; Sawada, Y; Shoyama, Y; Tian, R | 1 |
| Agrimonti, C; Andreotti, E; Bianchi, A; Conforti, F; Menichini, F; Poli, F; Sacchetti, G; Statti, GA; Tundis, R | 1 |
| Ang, CY; Drumm, P; Liu, F; Pan, C | 1 |
| Bässler, D; Schulz, HU; Schürer, M; Weiser, D | 3 |
| Dong, JF; Xu, MJ; Zhang, G | 1 |
| Altieri, V; Borrelli, F; Capasso, F; Capasso, R; Izzo, AA; Montanaro, V | 1 |
| Beattie, PE; Ferguson, J; Ibbotson, SH; Moseley, H; Traynor, NJ; Woods, JA | 1 |
| Gadzovska, S; Hagège, D; Joseph, C; Kascakova, S; Maury, S; Ounnar, S; Refregiers, M; Righezza, M; Spasenoski, M | 1 |
| Dong, JF; Xu, MJ; Zhu, MY | 1 |
| Bobrov, N; Brezáni, P; Cavarga, I; Fedorocko, P; Longauer, F; Mirossay, L; Miskovský, P; Rybárova, S; Stubna, J | 2 |
| Avery, BA; Shah, AK; Wyandt, CM | 1 |
| Beattie, PE; Dawe, RS; Ferguson, J; Ibbotson, SH; Traynor, NJ; Woods, JA | 1 |
| Lawvere, S; Mahoney, MC | 1 |
| Ashton, D; Chandrasekera, DH; Heinrich, M; Middleton, R; Welham, KJ | 1 |
| Furumoto, M; Haito, S; Ito, M; Kawai, Y; Miyamoto, K; Terao, J | 1 |
| Filippidis, G; Gioti, E; Meyer, H; Papazoglou, TG; Skalkos, D; Stalikas, CD | 1 |
| Cellárová, E; Kosuth, J; Urbanová, M | 1 |
| Girard, J; Sander, LC; Williams, FB; Wise, SA | 1 |
| Chessa, M; Pintore, G; Ricci, A; Sighinolfi, S; Tirillini, B | 1 |
| Smelcerovic, A; Spiteller, M; Zuehlke, S | 1 |
| Schubert-Zsilavecz, M; Wurglics, M | 1 |
| Birt, DF; Dixon, PM; Liu, Y; Murphy, PA; Petrich, JW; Schmitt, LA | 1 |
| Afreen, F; Goto, E; Kozai, T; Zobayed, SM | 1 |
| Calvo, A; Martínez, I; Portolés, A; Resplandy, G; Terleira, A | 1 |
| Cellárová, E; Katkovcinová, Z; Kosuth, J; Olexová, P | 1 |
| Weber, B | 1 |
| Liu, CS; Wang, DM; Yang, DP | 1 |
| Cellárová, E; Koperdáková, J; Kosuth, J | 1 |
| Dobrić, S; Savikin, K; Tadić, V; Zdunić, G | 1 |
| Bolling, SF; Chang, SC; Gibson, DM; Kaufman, PB; Kirakosyan, A; Kornfeld, A; Lu, CR; Warber, SL | 1 |
| Cao, J; Chan, E; Chen, X; Duan, W; Hu, ZP; Huang, M; Wen, JY; Yang, XX; Yu, XQ; Zhou, SF | 1 |
| Lv, HF; Song, X; Zhu, J | 1 |
| Exner, M; Gmeiner, BM; Hermann, M; Kapiotis, S; Laggner, H; Mühl, A; Schreier, S | 1 |
| Bornancin, A; Della Loggia, R; Morazzoni, P; Pace, R; Riva, A; Sosa, S; Tubaro, A | 1 |
| Gödtel-Armbrust, U; Kelber, O; Kroll, U; Metzger, A; Wojnowski, L | 1 |
| Klejdus, B; Kuban, V; Pavlík, M; Vacek, J | 1 |
| Actor, JK; Dasgupta, A; Hovanetz, M; Olsen, M; Wells, A | 1 |
| Klejdus, B; Kubán, V; Vacek, J | 1 |
| Hu, ZH; Lv, HF; Shao, MM; Sun, DL; Zhou, CH | 1 |
| Birt, DF; Delate, K; Dixon, PM; Hammer, KD; Hillwig, ML; Murphy, PA; Solco, AK; Wurtele, ES | 1 |
| Butterweck, V; Schmidt, M | 1 |
| Avramakis, E; Dörnemann, D; Kotzabasis, K; Navakoudis, E; Stavropoulos, E; Xenophontos, M | 1 |
| Exarchou, V; Gerothanassis, IP; Tatsis, EC; Troganis, AN | 1 |
| Kusari, S; Lamshöft, M; Spiteller, M; Zühlke, S | 1 |
| Beffy, P; D'Aleo, V; Lupi, R; Marchetti, P; Masiello, P; Menegazzi, M; Novelli, M; Suzuki, H; Tedeschi, E; Zoratti, E | 1 |
| Canegallo, L; Carrassi, A; Demarosi, F; Lodi, G; Sardella, A; Tarozzi, M | 1 |
| Higuchi, A; Jo, N; Matsumura, M; Yamada, E; Yamada, H | 1 |
| Contartese, G; Couladis, M; Galati, EM; Lanuzza, F; Miceli, N; Sdrafkakis, V; Taviano, MF; Tzakou, O | 1 |
| Bujacz, G; Fernandes, H; Jaskolski, M; Kolodziejczyk, R; Konieczna, M; Sikorski, M | 1 |
| Bertoli, A; Giovannini, A; Guardo, AD; Mazzetti, M; Pistelli, L; Ruffoni, B; Spinelli, G | 1 |
| Hohtola, A; Hokkanen, J; Karppinen, K; Mattila, S; Neubauer, P | 1 |
| Avramakis, E; Dörnemann, D; Kotzabasis, K; Navakoudis, E; Stavropoulos, I; Xenophontos, M | 1 |
| Dong, J; Xu, M; Zhang, X | 1 |
| Birt, DF; Hammer, KD; Hillwig, ML; Kohut, ML; Neighbors, JD; Sim, YJ; Wiemer, DF; Wurtele, ES | 1 |
| Cirak, C; Ivanauskas, L; Janulis, V; Radusiene, J | 3 |
| Karakas, O; Onay, A; Ozen, HC; Tilkat, E; Toker, Z | 1 |
| Efferth, T; Kober, M; Pohl, K | 1 |
| Ayan, AK; Cirak, C | 1 |
| Khalifa, AE; Mohamed, MR; Sabry, GM; Sabry, NA; Tadros, MG; Youssef, AM | 1 |
| Chen, J; Chen, X; Du, J; Guan, S; He, YW; Huang, M; Li, JL; Su, QB; Wang, XD; Zeng, J; Zhang, JX; Zhou, SF | 1 |
| Bilia, AR; Karioti, A; Vincieri, FF | 1 |
| Kavanagh, DJ; Sarris, J | 1 |
| Borsch, T; Kusari, S; Spiteller, M; Zühlke, S | 1 |
| Borsarini, A; Caniato, R; Filippini, R; Piovan, A | 1 |
| Bai, J; Sun, F; Wang, D; Yang, D | 1 |
| Cellárová, E; Kosuth, J; Kusari, S; Spiteller, M; Zühlke, S | 1 |
| Fernandes, H; Jaskolski, M; Michalska, K; Sikorski, M | 1 |
| Booth, JN; McGwin, G | 1 |
| Bartolini, A; Bergonzi, MC; Bilia, AR; Galeotti, N; Ghelardini, C; Vivoli, E | 1 |
| Bilia, AR; Galeotti, N; Ghelardini, C; Vincieri, FF; Vivoli, E | 1 |
| Chang, Y; Wang, SJ | 1 |
| Caccia, S; Gobbi, M | 1 |
| Bilia, AR; Karioti, A | 1 |
| Butterweck, V; Nahrstedt, A | 1 |
| da Conceição, AO; Lafond, J; Takser, L | 1 |
| Gilani, AH; Khan, AU | 1 |
| Kisselev, P; Roots, I; Schunck, WH; Schwarz, D | 1 |
| Bai, G; Cao, X; Ito, Y; Li, Y; Ren, H; Wang, Q; Xu, C | 1 |
| Asadi, N; Dehghankhalili, M; Ghaffarpasand, F; Ghazanfarpour, M; Kaviani, M; Tabatabaee, HR; Ziyadlou, S | 1 |
| Dong, J; Jin, H; Lu, D; Sun, L; Xu, M; Xu, X; Yang, B; Zhu, Y | 1 |
| Mielcarek, S; Turnau, K; Zubek, S | 1 |
| Hatano, T; Inoue, R; Ito, H; Ochi, M; Onoue, S; Seto, Y; Yamada, S | 1 |
| Boevé, JL; Crockett, SL | 1 |
| Birt, DF; Hauck, C; Huang, N; Murphy, PA; Nikolau, BJ; Rizshsky, L | 1 |
| Hao, PF; Lei, GM; Liu, FG; Yang, Y | 1 |
| Birt, DF; Hauck, CC; Huang, N; Murphy, PA; Nikolau, BJ; Rizshsky, L | 1 |
| Miller, CD; Mortensen, T; Shen, F; Shen, S; Sims, RC; Walsh, MK | 1 |
| Baptista, J; Fernandes-Ferreira, M; Lima, E; Rainha, N | 1 |
| Caliskan, O; Camas, N; Cirak, C; Radusiene, J; Stanius, Z | 1 |
| Dalmizrak, O; Kulaksiz-Erkmen, G; Ozer, N | 1 |
| An, JM; Kong, JQ; Shi, YW; Wang, W; Yang, Y; Zheng, HN; Zhi, XH | 1 |
| Algar, E; Mañero, FJ; Martín Gómez, MS; Saco Sierra, MD; Solano, BR | 1 |
| Davids, LM; Sharma, KV | 1 |
| Capasso, R; Pessina, F; Valeri, A; Valoti, M | 1 |
| Lu, Y; Qian, J; Wu, J; Yao, B | 1 |
| Babula, P; Klejdus, B; Kováčik, J | 1 |
| Galeotti, N; Ghelardini, C | 1 |
| Caliskan, O; Camas, N; Cirak, C; Odabas, MS; Radusiene, J | 1 |
| Acar, M; Demircan, K; Gunduz, E; Gunduz, M; Ocak, Z; Ozlü, T; Uyeturk, U | 1 |
| Bouron, A; Lorrain, E | 1 |
| Chimirri, S; Ciriaco, M; De Sarro, G; Esposito, S; Mammì, M; Mazzitello, C; Palleria, C; Patanè, M; Pugliese, M; Russo, E; Scicchitano, F; Upton, R; Whalley, BJ | 1 |
| Barras, A; Boukherroub, R; Boussekey, L; Courtade, E | 1 |
| Burico, M; Galeotti, N; Ghelardini, C; Maidecchi, A; Mattoli, L | 1 |
| Birt, DF; Hammer, KD | 1 |
| Chen, SL; Huang, LF; Wang, ZH | 1 |
| Cvejić, J; Goločorbin-Kon, S; Mikov, M; Mimica-Dukić, N; Rašković, A; Stilinović, N; Vukmirović, S | 1 |
| Bianchi, E; Farzad, M; Galeotti, N; Ghelardini, C | 1 |
| Wang, Q; Xu, FF | 1 |
| Conforti, F; Marrelli, M; Menichini, F; Nicoletti, M; Statti, G; Toniolo, C | 1 |
| Hou, Y; Li, D; Li, S; Li, Z; Qin, C; Sun, J | 1 |
| Fedoročko, P; Hiľovská, L; Jendželovská, Z; Jendželovský, R; Kovaľ, J; Mikeš, J | 1 |
| Davids, LM; Kleemann, B; Lang, D; Loos, B; Scriba, TJ | 1 |
| Akbaş, F; Işıkalan, C; Namlı, S; Tilkat, EA; Toker, Z | 1 |
| Nair, AR; Pillai, PP | 1 |
| Kim, YS; Murthy, HN; Paek, KY; Park, SY | 1 |
| Arakawa, NS; Cardoso, RD; Casagrande, R; Fattori, V; Hohmann, MS; Lopes, NP; Tomaz, JC; Verri, WA | 1 |
| Cellarova, E; Kusari, S; Nigutova, K; Sezgin, S; Spiteller, M | 1 |
| Abdel-Aziz, H; Brügger, D; Butterweck, V; Verjee, S | 1 |
| Alves, G; Domingues, F; Duarte, AP; Gallardo, E; Granadeiro, LB; Martinho, A; Moreno, I; Silva, SM; Silvestre, S | 1 |
| Avramescu, S; Branger, C; Florea, AM; Ghiurea, M; Hubca, G; Iordache, TV; Sârbu, A | 1 |
| Čellárová, E; Janfelt, C; Kimáková, K; Kucharíková, A | 1 |
| Jiang, Y; Kou, J; Li, H; Li, X; Liu, Z; Shao, Q; Tian, Y; Wu, J; Yang, L; Zheng, X; Zhong, Z; Zhu, X | 1 |
| Bruňáková, K; Čellárová, E | 1 |
| Franklin, G; Hou, W; Singh, RK | 1 |
| Carrubba, A; Lazzara, S; Militello, M; Napoli, E; Saia, S | 1 |
| Ho, CY; Ng, QX; Venkatanarayanan, N | 1 |
| Abdel-Aziz, H; Butterweck, V; Kelber, O; Kolb, C; Verjee, S | 1 |
| Kontaxis, NI; Lamari, FN; Margianni, E; Petrou, C; Zeliou, K | 1 |
| Bálintová, M; Čellárová, E; Henzelyová, J; Kusari, S; Nigutová, K; Petijová, L; Sezgin, S; Spiteller, M | 1 |
| Aghazadeh, M; Khadem Nezhad, S; Samadi Kafil, H; Taghavi Zenouz, A | 1 |
| Kim, HA; Kim, HJ; Kook, JH; You, MK | 1 |
| Barbosa, PM; Bruschi, ML; Caetano, W; César, GB; Gonçalves, RS; Hioka, N; Nakamura, CV | 1 |
| Dresler, S; Kováčik, J; Sowa, I; Strzemski, M; Wójciak-Kosior, M | 1 |
| Bruňáková, K; Čellárová, E; Kimáková, K; Petijová, L | 1 |
| Franzese, O; Marini, M; Rinaldi, A; Roscetti, G; Valletta, E | 1 |
| Čellárová, E; Idkowiak, J; Kimáková, A; Kimáková, K; Marczak, Ł; Rodziewicz, P; Stobiecki, M | 1 |
| Ashby, NJS; Bar-Shaked, M; Ben-Eliezer, D; Yechiam, E | 1 |
| Bruni, R; Cruciani, G; Dall'Asta, C; Dellafiora, L; Galaverna, G | 1 |
| Ashrafi, B; Bahmani, M; Heydari, R; Khaksarian, M; Soroush, S; Taherikalani, M | 1 |
| Boonen, G; Bussmann, H; Drewe, J; Franken, S; Häberlein, H; Keksel, N; Unger, M | 1 |
| Jin, L; Kang, T; Li, M; Liu, Z; Sun, P; Xing, H; Yao, Y; Zhang, Z | 1 |
| Altschmied, L; Bäumlein, H; Borisjuk, L; Franke, K; Gündel, A; Koch, M; Rizzo, P; Rutten, T; Scharfenberg, S; Sharbel, TF; Stark, P; Wessjohann, L | 1 |
| Cao, YF; Chen, TR; Dou, TY; Fang, HB; Ge, GB; Guo, WZ; Hou, J; Jin, Q; Wei, LH; Yu, Y; Zhang, SJ | 1 |
| Csupor, D; Kiss, N; Kocsubé, S; Németh, A; Papp, T; Rakk, D; Škrbić, B; Szekeres, A; Vágvölgyi, C; Vigneshwari, A | 1 |
| Hatamipour, MS; Khanahmadi, M; Najafipour, I; Sadeh, P; Tahmasebi-Boldaji, R | 1 |
| Kılıç Süloğlu, A; Selmanoğlu, G; Sünnetçioğlu, MM; Yonar, D | 1 |
| Behroozi, P; Ebrahimi, M; Khanahmadi, M; Moradi, K; Noormohammadi, N; Sobhani Najafabadi, A | 1 |
| Carrubba, A; Lazzara, S; Napoli, E | 1 |
| Chorilli, M; de Araújo, PR; Fonseca-Santos, B; Kogawa, AC; Salgado, HRN | 1 |
| Bálintová, M; Čellárová, E; Henzelyová, J; Kusari, S; Revuru, B | 1 |
| Cruz, RCR; de Sousa, FD; de Souza, LM; Francielli de Oliveira, P; Tavares, DC | 1 |
| Altschmied, L; D'Auria, JC; Ravindran, BM; Rizzo, P; Rutten, T | 1 |
| Chen, S; Li, J; Li, M; Su, H; Sun, P; Wei, J; Xing, H; Yang, D; Zhang, X | 1 |
| Li, Y; Li, Z; Liang, C; Liu, L; Sun, Y; Yang, G; Zheng, L | 1 |
| Saçıcı, E; Yesilada, E | 1 |
| Guan, QY; Han, YB; Tan, RX; Wang, XC; Wu, XM; Zhuang, WY | 1 |
| Chen, J; Dou, T; Ge, G; Liu, K; Meng, Q; Sun, H; Wang, C; Wang, D; Wu, J; Zhao, S; Zhao, T | 1 |
| Abbasi, N; Ashrafi, B; Bahmani, M; Khaksarian, M; Rafieian-Kopaei, M; Taherikalani, M | 1 |
29 review(s) available for perylene and hypericum
| Article | Year |
|---|---|
Clinical investigation of the antidepressant effectiveness of hypericum.
Topics: Antidepressive Agents; Humans; Hypericum; Perylene; Plant Extracts; Plants, Medicinal; Quercetin; Xanthenes | 1994 |
St John's wort for depression--an overview and meta-analysis of randomised clinical trials.
Topics: Antidepressive Agents; Depressive Disorder; Dose-Response Relationship, Drug; Drug Combinations; Humans; Hypericum; Perylene; Plant Extracts; Plants, Medicinal; Quercetin; Randomized Controlled Trials as Topic; Treatment Outcome; Xanthenes | 1996 |
Controlled clinical trials of hypericum extracts in depressed patients--an overview.
Topics: Antidepressive Agents; Controlled Clinical Trials as Topic; Depressive Disorder; Humans; Hypericum; Perylene; Plant Extracts; Plants, Medicinal; Quercetin; Xanthenes | 1997 |
Can an herb really help depression?
Topics: Antidepressive Agents; Depressive Disorder; Humans; Hypericum; Nonprescription Drugs; Perylene; Plants, Medicinal; Quercetin; Xanthenes | 1998 |
St. John's Wort (Hypericum perforatum): clinical effects on depression and other conditions.
Topics: Depression; Depressive Disorder; Humans; Hypericum; Perylene; Plant Extracts; Plants, Medicinal; Quercetin; Xanthenes | 1998 |
Incidence and clinical relevance of the interactions and side effects of Hypericum preparations.
Topics: Anthracenes; Antidepressive Agents; Clinical Trials as Topic; Contraindications; Dermatitis, Phototoxic; Drug Interactions; Epidemiologic Studies; Herb-Drug Interactions; Humans; Hypericum; Incidence; Perylene; Photosensitizing Agents; Plant Extracts; Plants, Medicinal; Radiation-Sensitizing Agents | 2001 |
A systematic review and meta-analysis of Hypericum perforatum in depression: a comprehensive clinical review.
Topics: Anthracenes; Antidepressive Agents; Clinical Trials as Topic; Depressive Disorder; Humans; Hypericum; Perylene; Phytotherapy; Treatment Outcome | 2001 |
Final report on the safety assessment of Hypericum perforatum extract and Hypericum perforatum oil.
Topics: Administration, Oral; Animals; Anthracenes; Chemistry, Pharmaceutical; Cosmetics; Depressive Disorder; Dizziness; Fatigue; Guinea Pigs; Humans; Hypericum; Immune System; Mice; Mutagenicity Tests; Perylene; Photosensitivity Disorders; Plant Preparations; Rats; Safety; Skin Diseases; Toxicity Tests | 2001 |
Hypericin in cancer treatment: more light on the way.
Topics: Anthracenes; Antineoplastic Agents; Apoptosis; Cytochrome c Group; HeLa Cells; Humans; Hypericum; Microscopy, Fluorescence; Models, Biological; Molecular Structure; Neoplasms; Perylene; Photochemotherapy; Photosensitizing Agents; Proto-Oncogene Proteins c-bcl-2; Signal Transduction | 2002 |
[Formulation of St. John's wort extract. A medicinal obstacle course].
Topics: Anthracenes; Bridged Bicyclo Compounds; Chemistry, Pharmaceutical; Drug Compounding; Humans; Hypericum; Perylene; Phloroglucinol; Plant Extracts; Solvents; Terpenes | 2003 |
The production of hypericins and hyperforin by in vitro cultures of St. John's wort (Hypericum perforatum).
Topics: Anthracenes; Anti-Bacterial Agents; Antineoplastic Agents; Bridged Bicyclo Compounds; Culture Techniques; Hypericum; Perylene; Phloroglucinol; Plants, Medicinal; Terpenes | 2004 |
The antidepressant mechanism of Hypericum perforatum.
Topics: Animals; Anthracenes; Bridged Bicyclo Compounds; Depression; Disease Models, Animal; Hypericum; Neurotransmitter Agents; Perylene; Phloroglucinol; Phytotherapy; Plant Extracts; Rats; Receptors, Dopamine D1; Receptors, Opioid; Terpenes | 2004 |
St. John's wort.
Topics: Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Depression; Humans; Hypericum; Perylene; Phloroglucinol; Phytotherapy; Plant Preparations; Terpenes; Treatment Outcome | 2005 |
Hypericum perforatum: a 'modern' herbal antidepressant: pharmacokinetics of active ingredients.
Topics: Animals; Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Clinical Trials as Topic; Depression; Flavonoids; Humans; Hypericum; Perylene; Phloroglucinol; Phytotherapy; Plant Extracts; Terpenes | 2006 |
[Hypericin and hyperforin: bioactive components of St. John's Wort (Hypericum perforatum). Their isolation, analysis and study of physiological effect].
Topics: Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Depressive Disorder; Humans; Hypericum; Perylene; Phloroglucinol; Phytotherapy; Plant Extracts; Plants, Medicinal; Terpenes | 2007 |
St. John's wort: role of active compounds for its mechanism of action and efficacy.
Topics: Animals; Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Cells, Cultured; Clinical Trials as Topic; Disease Models, Animal; Humans; Hypericum; Ice; Meta-Analysis as Topic; Perylene; Phloroglucinol; Phytotherapy; Plant Extracts; Terpenes | 2007 |
Molecular mechanisms underlying St. John's wort drug interactions.
Topics: Animals; Anthracenes; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cytochrome P-450 CYP3A; Enzyme Induction; Herb-Drug Interactions; Humans; Hypericum; Perylene; Photochemotherapy | 2008 |
Kava and St. John's Wort: current evidence for use in mood and anxiety disorders.
Topics: Anthracenes; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Bridged Bicyclo Compounds; Humans; Hypericum; Kava; Mood Disorders; Perylene; Phloroglucinol; Phytotherapy; Plant Extracts; Terpenes | 2009 |
St. John's wort components and the brain: uptake, concentrations reached and the mechanisms underlying pharmacological effects.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Blood-Brain Barrier; Brain; Bridged Bicyclo Compounds; Flavonols; Humans; Hypericum; Nootropic Agents; Permeability; Perylene; Phloroglucinol; Plant Preparations; Psychotropic Drugs; Terpenes | 2009 |
Hypericins as potential leads for new therapeutics.
Topics: Anthracenes; Anti-Infective Agents; Antidepressive Agents; Cell Survival; Humans; Hypericum; Neoplasms; Perylene; Photochemotherapy; Photosensitizing Agents | 2010 |
Lessons learned from herbal medicinal products: the example of St. John's Wort (perpendicular).
Topics: Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Hypericum; Molecular Structure; Perylene; Phloroglucinol; Plant Preparations; Plants, Medicinal; Terpenes | 2010 |
[Cellular and molecular effects of the antidepressant hyperforin on brain cells: Review of the literature].
Topics: Anthracenes; Antidepressive Agents; Brain; Hypericum; Neurons; Perylene; Phloroglucinol; Terpenes | 2014 |
Hypericum perforatum: pharmacokinetic, mechanism of action, tolerability, and clinical drug-drug interactions.
Topics: Anthracenes; Antidepressive Agents; Antiviral Agents; Depression; Herb-Drug Interactions; Humans; Hypericum; Perylene; Phloroglucinol; Plant Extracts; Plants, Medicinal; Terpenes | 2014 |
Evidence for contributions of interactions of constituents to the anti-inflammatory activity of Hypericum perforatum.
Topics: Animals; Anti-Inflammatory Agents; Biflavonoids; Disease Models, Animal; Flavonoids; Humans; Hypericum; Perylene; Phloroglucinol; Plant Extracts; Signal Transduction; Terpenes | 2014 |
Hypericin: chemical synthesis and biosynthesis.
Topics: Anthracenes; Antineoplastic Agents, Phytogenic; Antiviral Agents; Humans; Hypericum; Perylene; Plant Extracts | 2014 |
Hypericins: biotechnological production from cell and organ cultures.
Topics: Anthracenes; Biological Products; Biotechnology; Cell Culture Techniques; Hypericum; Perylene; Technology, Pharmaceutical | 2014 |
Clinical use of Hypericum perforatum (St John's wort) in depression: A meta-analysis.
Topics: Anthracenes; Antidepressive Agents; Depression; Humans; Hypericum; Perylene; Phloroglucinol; Phytotherapy; Plant Extracts; Selective Serotonin Reuptake Inhibitors; Terpenes | 2017 |
A Review of Analytical Methods for the Determination of Hypericin in Foods, Herbal, Biological and Pharmaceutical Matrices.
Topics: Anthracenes; Humans; Hypericum; Perylene; Pharmaceutical Preparations; Photosensitizing Agents | 2020 |
The Biochemical and Genetic Basis for the Biosynthesis of Bioactive Compounds in
Topics: Anthracenes; Antidepressive Agents; Antineoplastic Agents; Europe; Humans; Hypericum; Perylene; Phloroglucinol; Phytochemicals; Plant Extracts; Plant Proteins; Terpenes | 2020 |
30 trial(s) available for perylene and hypericum
| Article | Year |
|---|---|
Hypericum treatment of mild depressions with somatic symptoms.
Topics: Adult; Aged; Antidepressive Agents; Depression; Double-Blind Method; Female; Humans; Hypericum; Male; Middle Aged; Perylene; Plant Extracts; Plants, Medicinal; Psychometrics; Quercetin; Xanthenes | 1994 |
Multicenter double-blind study examining the antidepressant effectiveness of the hypericum extract LI 160.
Topics: Adolescent; Adult; Aged; Antidepressive Agents; Depression; Double-Blind Method; Female; Humans; Hypericum; Male; Middle Aged; Perylene; Plant Extracts; Plants, Medicinal; Psychometrics; Quercetin; Self-Assessment; Xanthenes | 1994 |
Effectiveness and tolerance of the hypericum extract LI 160 in comparison with imipramine: randomized double-blind study with 135 outpatients.
Topics: Adult; Aged; Antidepressive Agents; Depression; Double-Blind Method; Female; Humans; Hypericum; Imipramine; Male; Middle Aged; Perylene; Plant Extracts; Plants, Medicinal; Psychometrics; Quercetin; Severity of Illness Index; Xanthenes | 1994 |
Effectiveness and tolerance of the hypericum extract LI 160 compared to maprotiline: a multicenter double-blind study.
Topics: Adult; Aged; Antidepressive Agents; Depression; Double-Blind Method; Female; Humans; Hypericum; Male; Maprotiline; Middle Aged; Perylene; Plant Extracts; Plants, Medicinal; Psychometrics; Quercetin; Severity of Illness Index; Treatment Outcome; Xanthenes | 1994 |
Hypericum in the treatment of seasonal affective disorders.
Topics: Adult; Aged; Antidepressive Agents; Combined Modality Therapy; Female; Humans; Hypericum; Male; Middle Aged; Perylene; Phototherapy; Pilot Projects; Plant Extracts; Plants, Medicinal; Psychometrics; Quercetin; Seasonal Affective Disorder; Single-Blind Method; Xanthenes | 1994 |
Benefits and risks of the hypericum extract LI 160: drug monitoring study with 3250 patients.
Topics: Adult; Aged; Aged, 80 and over; Antidepressive Agents; Depression; Drug Monitoring; Female; Humans; Hypericum; Male; Middle Aged; Patient Dropouts; Perylene; Plant Extracts; Plants, Medicinal; Quercetin; Risk Factors; Treatment Outcome; Xanthenes | 1994 |
Effects of hypericum extract on the sleep EEG in older volunteers.
Topics: Anthracenes; Antidepressive Agents; Cross-Over Studies; Double-Blind Method; Electroencephalography; Female; Humans; Hypericum; Middle Aged; Perylene; Plant Extracts; Plants, Medicinal; Quercetin; Sleep; Xanthenes | 1994 |
Effects of hypericum extract LI 160 compared with maprotiline on resting EEG and evoked potentials in 24 volunteers.
Topics: Adolescent; Adult; Antidepressive Agents; Double-Blind Method; Electroencephalography; Evoked Potentials, Auditory; Evoked Potentials, Visual; Female; Humans; Hypericum; Male; Maprotiline; Middle Aged; Perylene; Plant Extracts; Plants, Medicinal; Quercetin; Xanthenes | 1994 |
Pharmacokinetics of hypericin and pseudohypericin after oral intake of the hypericum perforatum extract LI 160 in healthy volunteers.
Topics: Administration, Oral; Adult; Anthracenes; Antidepressive Agents; Chromatography, High Pressure Liquid; Double-Blind Method; Humans; Hypericum; Male; Perylene; Plant Extracts; Plants, Medicinal; Quercetin; Reference Values; Regression Analysis; Xanthenes | 1994 |
Placebo-controlled double-blind study examining the effectiveness of an hypericum preparation in 105 mildly depressed patients.
Topics: Adult; Aged; Antidepressive Agents; Depression; Double-Blind Method; Female; Humans; Hypericum; Male; Middle Aged; Perylene; Plant Extracts; Plants, Medicinal; Quercetin; Xanthenes | 1994 |
LI 160, an extract of St. John's wort, versus amitriptyline in mildly to moderately depressed outpatients--a controlled 6-week clinical trial.
Topics: Adult; Aged; Amitriptyline; Antidepressive Agents; Antidepressive Agents, Tricyclic; Depression; Double-Blind Method; Female; Humans; Hypericum; Male; Middle Aged; Outpatients; Perylene; Plants, Medicinal; Psychiatric Status Rating Scales; Quercetin; Xanthenes | 1997 |
Efficacy and tolerability of St. John's wort extract LI 160 versus imipramine in patients with severe depressive episodes according to ICD-10.
Topics: Adult; Aged; Antidepressive Agents; Antidepressive Agents, Tricyclic; Depressive Disorder; Double-Blind Method; Female; Humans; Hypericum; Imipramine; Male; Middle Aged; Perylene; Plants, Medicinal; Psychiatric Status Rating Scales; Quercetin; Xanthenes | 1997 |
The effect of hypericum extract on cardiac conduction as seen in the electrocardiogram compared to that of imipramine.
Topics: Adult; Aged; Antidepressive Agents; Antidepressive Agents, Tricyclic; Depressive Disorder; Double-Blind Method; Electrocardiography; Female; Heart Conduction System; Humans; Hypericum; Imipramine; Male; Middle Aged; Perylene; Plants, Medicinal; Psychiatric Status Rating Scales; Quercetin; Xanthenes | 1997 |
Treatment of seasonal affective disorder (SAD) with hypericum extract.
Topics: Adult; Antidepressive Agents; Combined Modality Therapy; Female; Humans; Hypericum; Male; Middle Aged; Perylene; Phototherapy; Plants, Medicinal; Psychiatric Status Rating Scales; Quercetin; Seasonal Affective Disorder; Single-Blind Method; Xanthenes | 1997 |
Oral bioavailability of hyperforin from hypericum extracts in rats and human volunteers.
Topics: Administration, Oral; Adult; Animals; Area Under Curve; Biological Availability; Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Female; Half-Life; Humans; Hypericum; Male; Perylene; Phloroglucinol; Plant Extracts; Plants, Medicinal; Quercetin; Rats; Rats, Sprague-Dawley; Terpenes; Xanthenes | 1998 |
Pharmacodynamic effects of two different hypericum extracts in healthy volunteers measured by quantitative EEG.
Topics: Adult; Anthracenes; Bridged Bicyclo Compounds; Cerebral Cortex; Electroencephalography; Female; Humans; Hypericum; Male; Perylene; Phloroglucinol; Plant Extracts; Plants, Medicinal; Quercetin; Terpenes; Xanthenes | 1998 |
St. John's wort in mild to moderate depression: the relevance of hyperforin for the clinical efficacy.
Topics: Antidepressive Agents; Bridged Bicyclo Compounds; Depressive Disorder; Double-Blind Method; Female; Humans; Hypericum; Male; Middle Aged; Perylene; Phloroglucinol; Plant Extracts; Plants, Medicinal; Quercetin; Terpenes; Xanthenes | 1998 |
Effect of topical application of Hypericum perforatum extract (St. John's wort) on skin sensitivity to solar simulated radiation.
Topics: Administration, Cutaneous; Adolescent; Adult; Anthracenes; Erythema; Female; Forearm; Humans; Hypericum; Male; Middle Aged; Ointments; Perylene; Photosensitizing Agents; Plant Extracts; Plant Oils; Plants, Medicinal; Prospective Studies; Radiation-Sensitizing Agents; Reference Values; Skin; Sunlight | 2000 |
Oral bioavailability of active principles from herbal products in humans. A study on Hypericum perforatum extracts using the soft gelatin capsule technology.
Topics: Administration, Oral; Adult; Anthracenes; Antidepressive Agents; Area Under Curve; Biological Availability; Bridged Bicyclo Compounds; Capsules; Chromatography, High Pressure Liquid; Cross-Over Studies; Female; Gelatin; Humans; Hypericum; Male; Mass Spectrometry; Perylene; Phloroglucinol; Plant Extracts; Plants, Medicinal; Reference Values; Terpenes | 2000 |
Single-dose and steady-state administration of Hypericum perforatum extract (St John's Wort) does not influence skin sensitivity to UV radiation, visible light, and solar-simulated radiation.
Topics: Animals; Anthracenes; Data Interpretation, Statistical; Erythema; Humans; Hypericum; Perylene; Plants, Medicinal; Prospective Studies; Radiation-Sensitizing Agents; Skin; Sunlight; Time Factors; Ultraviolet Rays | 2001 |
Researching the antidepressant actions of Hypericum perforatum (St. John's wort) in animals and man.
Topics: Adult; Animals; Anthracenes; Antidepressive Agents; Brain Chemistry; Bridged Bicyclo Compounds; Corticosterone; Cross-Over Studies; Double-Blind Method; Humans; Hypericum; Ketanserin; Male; Middle Aged; Neurosecretory Systems; Perylene; Phloroglucinol; Piperazines; Plant Extracts; Prolactin; Pyridines; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Antagonists; Terpenes | 2001 |
Impact of cytochrome P-450 inhibition by cimetidine and induction by carbamazepine on the kinetics of hypericin and pseudohypericin in healthy volunteers.
Topics: Adult; Anthracenes; Antidepressive Agents; Area Under Curve; Carbamazepine; Chromatography, High Pressure Liquid; Cimetidine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Double-Blind Method; Drug Interactions; Enzyme Inhibitors; Humans; Hypericum; Perylene; Time Factors | 2004 |
Influence of St John's wort on catecholamine turnover and cardiovascular regulation in humans.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic Uptake Inhibitors; Adult; Anthracenes; Autonomic Nervous System; Cardiovascular Physiological Phenomena; Catecholamines; Cross-Over Studies; Double-Blind Method; Female; Hemodynamics; Humans; Hypericum; Imipramine; Male; Methoxyhydroxyphenylglycol; Nitric Oxide Donors; Nitroprusside; Norepinephrine; Perylene; Posture; Supine Position | 2004 |
Investigation of the bioavailability of hypericin, pseudohypericin, hyperforin and the flavonoids quercetin and isorhamnetin following single and multiple oral dosing of a hypericum extract containing tablet.
Topics: Adolescent; Adult; Anthracenes; Antidepressive Agents; Area Under Curve; Biological Availability; Bridged Bicyclo Compounds; Flavonols; Humans; Hypericum; Male; Middle Aged; Perylene; Phloroglucinol; Plant Extracts; Quercetin; Tablets; Terpenes | 2005 |
Investigation of pharmacokinetic data of hypericin, pseudohypericin, hyperforin and the flavonoids quercetin and isorhamnetin revealed from single and multiple oral dose studies with a hypericum extract containing tablet in healthy male volunteers.
Topics: Adolescent; Adult; Anthracenes; Bridged Bicyclo Compounds; Flavonols; Humans; Hypericum; Male; Middle Aged; Perylene; Phloroglucinol; Plant Extracts; Quercetin; Tablets; Terpenes | 2005 |
Investigation of the effect on photosensitivity following multiple oral dosing of two different hypericum extracts in healthy men.
Topics: Adolescent; Adult; Anthracenes; Erythema; Humans; Hypericum; Hypersensitivity; Light; Male; Middle Aged; Perylene; Plant Extracts; Skin | 2006 |
Effects of Hypericum perforatum on ivabradine pharmacokinetics in healthy volunteers: an open-label, pharmacokinetic interaction clinical trial.
Topics: Administration, Oral; Adult; Anthracenes; Area Under Curve; Benzazepines; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Electrocardiography; Female; Gastrointestinal Tract; Half-Life; Headache; Heart Rate; Herb-Drug Interactions; Humans; Hydrocortisone; Hypericum; Ivabradine; Male; Metabolic Clearance Rate; Perylene; Plant Preparations; Tablets | 2006 |
Hypericum perforatum extract in burning mouth syndrome: a randomized placebo-controlled study.
Topics: Aged; Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Burning Mouth Syndrome; Double-Blind Method; Female; Humans; Hypericum; Male; Middle Aged; Perylene; Phloroglucinol; Phytotherapy; Plant Extracts; Statistics, Nonparametric; Terpenes; Treatment Outcome | 2008 |
Hypericum perforatum for the treatment of premenstrual syndrome.
Topics: Adult; Anthracenes; Double-Blind Method; Female; Humans; Hypericum; Perylene; Phytotherapy; Premenstrual Syndrome; Prospective Studies; Severity of Illness Index; Treatment Outcome; Young Adult | 2011 |
The acute effect of Hypericum perforatum on short-term memory in healthy adults.
Topics: Adult; Affect; Anthracenes; Anxiety; Attention; Double-Blind Method; Female; Healthy Volunteers; Humans; Hypericum; Male; Memory, Short-Term; Nootropic Agents; Perylene; Plant Preparations; Young Adult | 2019 |
233 other study(ies) available for perylene and hypericum
| Article | Year |
|---|---|
Inhibition of MAO and COMT by hypericum extracts and hypericin.
Topics: Animals; Anthracenes; Antidepressive Agents; Catechol O-Methyltransferase Inhibitors; Hypericum; In Vitro Techniques; Monoamine Oxidase Inhibitors; Perylene; Plant Extracts; Plants, Medicinal; Quercetin; Swine; Xanthenes | 1994 |
Inhibition of MAO by fractions and constituents of hypericum extract.
Topics: Animals; Antidepressive Agents; Hypericum; In Vitro Techniques; Male; Monoamine Oxidase Inhibitors; Perylene; Plant Extracts; Plants, Medicinal; Quercetin; Rats; Xanthenes | 1994 |
Modulation of cytokine expression by hypericum extract.
Topics: Antidepressive Agents; Cytokines; Depression; Humans; Hypericum; In Vitro Techniques; Interleukin-1; Interleukin-6; Perylene; Pilot Projects; Plant Extracts; Plants, Medicinal; Quercetin; Tumor Necrosis Factor-alpha; Xanthenes | 1994 |
Effects of hypericum extract on the expression of serotonin receptors.
Topics: Animals; Antidepressive Agents; Hypericum; Interleukin-1; Neuroblastoma; Perylene; Plant Extracts; Plants, Medicinal; Quercetin; Rats; Receptors, Serotonin; Serotonin Antagonists; Tumor Cells, Cultured; Xanthenes | 1994 |
Pharmaceutical quality of hypericum extracts.
Topics: Anthracenes; Antidepressive Agents; Hypericum; Molecular Structure; Perylene; Plant Extracts; Plants, Medicinal; Quercetin; Xanthenes | 1994 |
St John's wort as an antidepressant.
Topics: Antidepressive Agents; Depressive Disorder; Humans; Hypericum; Perylene; Plant Extracts; Plants, Medicinal; Quercetin; Xanthenes | 1996 |
Pharmacological profile of hypericum extract. Effect on serotonin uptake by postsynaptic receptors.
Topics: Animals; Antidepressive Agents; Arachidonic Acid; Cell Survival; Cells, Cultured; DNA; Excitatory Amino Acid Agonists; HIV Envelope Protein gp120; Hypericum; N-Methylaspartate; Neurons; Perylene; Plant Extracts; Plants, Medicinal; Quercetin; Rats; Receptors, Neurotransmitter; Selective Serotonin Reuptake Inhibitors; Synaptosomes; Xanthenes | 1995 |
[A plant extract with proven antidepressive effect].
Topics: Antidepressive Agents; Clinical Trials as Topic; Depressive Disorder; Humans; Hypericum; Perylene; Plants, Medicinal; Quercetin; Selective Serotonin Reuptake Inhibitors; Treatment Outcome; Xanthenes | 1997 |
[Chemical composition of Hypericum perforatum and its effects].
Topics: Animals; Antidepressive Agents; Brain; Humans; Hypericum; Perylene; Plants, Medicinal; Quercetin; Selective Serotonin Reuptake Inhibitors; Synaptic Transmission; Xanthenes | 1997 |
[Antidepressive effectiveness and good tolerance].
Topics: Antidepressive Agents; Clinical Trials as Topic; Depressive Disorder; Humans; Hypericum; Perylene; Plants, Medicinal; Quercetin; Selective Serotonin Reuptake Inhibitors; Treatment Outcome; Xanthenes | 1997 |
[Hypericum perforatum in psychiatric practice].
Topics: Antidepressive Agents; Depressive Disorder; Dose-Response Relationship, Drug; Humans; Hypericum; Perylene; Plants, Medicinal; Quercetin; Selective Serotonin Reuptake Inhibitors; Xanthenes | 1997 |
[Reversible increase in photosensitivity to UV-B caused by St. John's wort extract].
Topics: Antidepressive Agents; Depressive Disorder; Dermatitis, Photoallergic; Drug Eruptions; Female; Humans; Hypericum; Middle Aged; Patch Tests; Perylene; Plants, Medicinal; Quercetin; Ultraviolet Rays; Xanthenes | 1997 |
Hypericum, an over the counter antidepressant?
Topics: Antidepressive Agents; Depressive Disorder; Drug Interactions; Humans; Hypericum; Nonprescription Drugs; Perylene; Plants, Medicinal; Quercetin; Treatment Outcome; Xanthenes | 1997 |
Effects of hypericum extract (LI 160) in biochemical models of antidepressant activity.
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Brain; Depression; Dopamine Uptake Inhibitors; Female; Hypericum; Imipramine; Mice; Monoamine Oxidase; Perylene; Plants, Medicinal; Prefrontal Cortex; Quercetin; Rats; Receptors, Adrenergic, beta; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Synaptosomes; Xanthenes | 1997 |
In vitro receptor binding and enzyme inhibition by Hypericum perforatum extract.
Topics: Animals; Antidepressive Agents; Enzyme Inhibitors; Hypericum; In Vitro Techniques; Monoamine Oxidase Inhibitors; Perylene; Plants, Medicinal; Quercetin; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Selective Serotonin Reuptake Inhibitors; Xanthenes | 1997 |
Effects of long-term administration of hypericum extracts on the affinity and density of the central serotonergic 5-HT1 A and 5-HT2 A receptors.
Topics: Animals; Antidepressive Agents; Autoreceptors; Brain Chemistry; Hypericum; Kinetics; Male; Membranes; Perylene; Plants, Medicinal; Quercetin; Rats; Rats, Sprague-Dawley; Receptors, Neurotransmitter; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Synaptosomes; Xanthenes | 1997 |
Central action of hyperici herba cum flore extractum siccum in freely moving rats.
Topics: Animals; Antidepressive Agents; Electroencephalography; Frontal Lobe; Hippocampus; Hypericum; Male; Perylene; Plant Extracts; Plants, Medicinal; Quercetin; Rats; Rats, Inbred F344; Xanthenes | 1997 |
Pharmacodynamic effects of St. John's Wort on rat intracerebral field potentials.
Topics: Action Potentials; Animals; Antidepressive Agents; Brain; Electrophysiology; Hypericum; Male; Perylene; Plant Extracts; Plants, Medicinal; Quercetin; Rats; Rats, Inbred F344; Xanthenes | 1995 |
St. John's wort.
Topics: Antidepressive Agents; Humans; Hypericum; Perylene; Photosensitivity Disorders; Plant Extracts; Plants, Medicinal; Quercetin; Randomized Controlled Trials as Topic; Selective Serotonin Reuptake Inhibitors; Xanthenes; Xerostomia | 1997 |
[Prediction: onset of improved mood after 2 weeks. Hypericum therapy in intermediate class depression. Interview by Dr. rer. nat. Till Uwe Keil].
Topics: Antidepressive Agents; Depressive Disorder; Humans; Hypericum; Perylene; Plants, Medicinal; Quercetin; Selective Serotonin Reuptake Inhibitors; Treatment Outcome; Xanthenes | 1997 |
Does St. John's wort have an effect on autonomic responses of cutaneous circulation?
Topics: Adult; Aged; Amitriptyline; Autonomic Nervous System; Female; Humans; Hypericum; Laser-Doppler Flowmetry; Male; Middle Aged; Perylene; Photoplethysmography; Plant Extracts; Plants, Medicinal; Quercetin; Respiration; Skin; Vasoconstriction; Vasodilation; Xanthenes | 1997 |
St. John's wort.
Topics: Antidepressive Agents; Humans; Hypericum; Perylene; Plants, Medicinal; Quercetin; Randomized Controlled Trials as Topic; Treatment Outcome; Xanthenes | 1998 |
Should you take St. John's Wort?
Topics: Depression; Depressive Disorder; Humans; Hypericum; Perylene; Phytotherapy; Plant Extracts; Plants, Medicinal; Quercetin; Xanthenes | 1998 |
Can you tell me about St. John's wort? I've been depressed and wonder if it would be safe to take.
Topics: Antidepressive Agents; Depression; Humans; Hypericum; Perylene; Plant Extracts; Plants, Medicinal; Quercetin; Xanthenes | 1998 |
New developments in family medicine.
Topics: Antidepressive Agents; Asthma; Continuity of Patient Care; Family Practice; Hepatitis C; Humans; Hypericum; Osteoporosis; Perylene; Physician-Patient Relations; Plants, Medicinal; Quercetin; United States; Xanthenes | 1998 |
Over-the-counter psychotropics: a review of melatonin, St John's wort, valerian, and kava-kava.
Topics: Anti-Anxiety Agents; Antidepressive Agents; Antioxidants; Complementary Therapies; Humans; Hypericum; Kava; Melatonin; Nonprescription Drugs; Perylene; Phytotherapy; Plant Extracts; Plants, Medicinal; Quercetin; United States; Valerian; Xanthenes | 1998 |
Antidepressant activity of hypericum perforatum and hyperforin: the neglected possibility.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Bridged Bicyclo Compounds; Cells, Cultured; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Guinea Pigs; Heart Rate; Hypericum; Ileum; In Vitro Techniques; Male; Muscle Contraction; Perylene; Phloroglucinol; Plant Extracts; Plants, Medicinal; Quercetin; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Terpenes; Xanthenes | 1998 |
Hyperforin represents the neurotransmitter reuptake inhibiting constituent of hypericum extract.
Topics: Animals; Brain; Bridged Bicyclo Compounds; Dopamine; Female; Hypericum; Male; Mice; Monoamine Oxidase; Neurotransmitter Uptake Inhibitors; Norepinephrine; Perylene; Phloroglucinol; Plant Extracts; Plants, Medicinal; Quercetin; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Receptors, Serotonin; Serotonin; Synaptosomes; Terpenes; Xanthenes | 1998 |
Activity profiles of two hyperforin-containing hypericum extracts in behavioral models.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Body Temperature; Bridged Bicyclo Compounds; Hypericum; Male; Mice; Perylene; Phloroglucinol; Plant Extracts; Plants, Medicinal; Quercetin; Rats; Stereotyped Behavior; Terpenes; Xanthenes | 1998 |
Effects of a methanolic extract and a hyperforin-enriched CO2 extract of St. John's Wort (Hypericum perforatum) on intracerebral field potentials in the freely moving rat (Tele-Stereo-EEG).
Topics: Animals; Brain; Bridged Bicyclo Compounds; Carbon Dioxide; Electrodes, Implanted; Electroencephalography; Hypericum; Male; Methanol; Perylene; Phloroglucinol; Plant Extracts; Plants, Medicinal; Quercetin; Rats; Terpenes; Xanthenes | 1998 |
Herbal healers.
Topics: Animals; Dermatitis, Photoallergic; Humans; Hypericum; Perylene; Phytotherapy; Plant Extracts; Plants, Medicinal; Quercetin; Safety; Selective Serotonin Reuptake Inhibitors; Xanthenes | 1998 |
Is St. John's wort (Hypericum perforatum) an effective antidepressant?
Topics: Animals; Anthracenes; Antidepressive Agents; Depressive Disorder; Humans; Hypericum; Nonprescription Drugs; Perylene; Phytotherapy; Plant Extracts; Plants, Medicinal; Protein Kinase C; Quercetin; Rats; Xanthenes | 1998 |
Hyperforin as a possible antidepressant component of hypericum extracts.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Bridged Bicyclo Compounds; Helplessness, Learned; Hypericum; Male; Models, Chemical; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neurotransmitter Uptake Inhibitors; Perylene; Phloroglucinol; Plant Extracts; Plants, Medicinal; Quercetin; Rats; Synaptosomes; Terpenes; Xanthenes | 1998 |
Hypericum LI 160 inhibits uptake of serotonin and norepinephrine in astrocytes.
Topics: Animals; Antidepressive Agents; Astrocytes; Cells, Cultured; Drug Evaluation, Preclinical; Hypericum; Norepinephrine; Perylene; Plant Extracts; Plants, Medicinal; Quercetin; Rats; Selective Serotonin Reuptake Inhibitors; Xanthenes | 1999 |
Phototoxic effects of Hypericum extract in cultures of human keratinocytes compared with those of psoralen.
Topics: Antidepressive Agents; Cells, Cultured; Dermatitis, Phototoxic; Ficusin; Humans; Hypericum; Keratinocytes; Perylene; Photosensitizing Agents; Plant Extracts; Plants, Medicinal; Quercetin; Spectrophotometry, Atomic; Ultraviolet Rays; Xanthenes | 1999 |
An alternative medicine study of herbal effects on the penetration of zona-free hamster oocytes and the integrity of sperm deoxyribonucleic acid.
Topics: Animals; Cricetinae; DNA; Female; Genes, BRCA1; Ginkgo biloba; Humans; Hypericum; Male; Oocytes; Perylene; Phytotherapy; Plant Extracts; Plants, Medicinal; Point Mutation; Prospective Studies; Quercetin; Serenoa; Sperm-Ovum Interactions; Spermatozoa; Xanthenes | 1999 |
In vitro transport and uptake of protohypericin and hypericin in the Caco-2 model.
Topics: Anthracenes; Biological Transport; Caco-2 Cells; Dose-Response Relationship, Drug; Humans; Hypericum; Light; Perylene; Plant Extracts; Plants, Medicinal; Time Factors | 1999 |
Stimulation of the production of hypericins by mannan in Hypericum perforatum shoot cultures.
Topics: Anthracenes; Cells, Cultured; Culture Techniques; Hypericum; Mannans; Perylene; Plant Shoots; Plants, Medicinal | 2000 |
Evidence that total extract of Hypericum perforatum affects exploratory behavior and exerts anxiolytic effects in rats.
Topics: Animals; Anthracenes; Anti-Anxiety Agents; Cerebellum; Electrophysiology; Exploratory Behavior; Flumazenil; GABA Modulators; GABA-A Receptor Antagonists; Hypericum; Male; Motor Activity; Patch-Clamp Techniques; Perylene; Plant Extracts; Plants, Medicinal; Rats; Rats, Sprague-Dawley; Receptors, GABA; Receptors, N-Methyl-D-Aspartate | 2000 |
Biochemical activities of extracts from Hypericum perforatum L. 5th communication: dopamine-beta-hydroxylase-product quantification by HPLC and inhibition by hypericins and flavonoids.
Topics: Anthracenes; Antidepressive Agents; Chromatography, High Pressure Liquid; Dopamine beta-Hydroxylase; Enzyme Inhibitors; Flavonoids; Hypericum; Norepinephrine; Oxygen; Perylene; Plant Extracts; Plants, Medicinal | 2000 |
Inhibition of human cytochrome P450 enzymes by constituents of St. John's Wort, an herbal preparation used in the treatment of depression.
Topics: Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Chlorogenic Acid; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors; Humans; Hypericum; Perylene; Phloroglucinol; Plant Extracts; Plants, Medicinal; Quercetin; Terpenes | 2000 |
Photooxidation of lens alpha-crystallin by hypericin (active ingredient in St. John's Wort).
Topics: Animals; Anthracenes; Antidepressive Agents; Cataract; Cattle; Crystallins; Humans; Hypericum; In Vitro Techniques; Oxidation-Reduction; Perylene; Photochemistry; Plants, Medicinal | 2000 |
St John's wort, a herbal antidepressant, activates the steroid X receptor.
Topics: Animals; Anthracenes; Antidepressive Agents; Aryl Hydrocarbon Hydroxylases; Binding, Competitive; Bridged Bicyclo Compounds; Corticosterone; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Histone Acetyltransferases; Humans; Hypericum; Mice; Nuclear Receptor Coactivator 1; Oxidoreductases, N-Demethylating; Perylene; Phloroglucinol; Plants, Medicinal; Pregnane X Receptor; Protein Binding; Receptors, Steroid; Rifampin; Terpenes; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured | 2000 |
[Flavonoid and dianthranoid levels of the St.-John's-wort flowering tops].
Topics: Anthracenes; Chromatography, High Pressure Liquid; Colorimetry; Flavonoids; Hypericum; ortho-Aminobenzoates; Perylene; Plants, Medicinal; Spectrophotometry, Ultraviolet | 2000 |
Acute effects of LI 160 (extract of Hypericum perforatum, St John's wort) and two of its constituents on neuroendocrine responses in the rat.
Topics: Animals; Anthracenes; Antidepressive Agents; Brain Chemistry; Catecholamines; Corticosterone; Dopamine Antagonists; Haloperidol; Hypericum; Male; Neurosecretory Systems; Perylene; Piperazines; Plant Extracts; Plants, Medicinal; Prolactin; Pyridines; Rats; Rats, Sprague-Dawley; Serotonin Antagonists | 2000 |
Seasonal variation in hypericin content of Hypericum perforatum L. (St. John's Wort).
Topics: Anthracenes; Hypericum; Perylene; Plant Leaves; Plants, Medicinal; Seasons; Spectrophotometry | 2001 |
Effect of light on hypericins contents in fresh flowering top parts and in an extract of St. John's Wort (Hypericum perforatum).
Topics: Anthracenes; Antidepressive Agents; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Hypericum; Perylene; Pigments, Biological; Plant Extracts; Plant Leaves; Plant Stems; Plants, Medicinal; Sunlight | 2001 |
Effect of St. John's wort on free radical production.
Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Anthracenes; Antioxidants; Bridged Bicyclo Compounds; Cell-Free System; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Free Radicals; Humans; Hypericum; Indicators and Reagents; Perylene; Phloroglucinol; Placenta; Plant Extracts; Plants, Medicinal; Pregnancy; Superoxides; Terpenes; Veins | 2001 |
Effects of two different extracts of St. John's wort and some of their constituents on cytochrome P450 activities in rat liver microsomes.
Topics: Animals; Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Cytochrome P-450 Enzyme System; Ethanol; Excitatory Amino Acid Antagonists; Female; Hypericum; Liver; Male; Methanol; Microsomes; Perylene; Phenobarbital; Phloroglucinol; Plant Extracts; Quercetin; Rats; Rats, Sprague-Dawley; Sex Factors; Solvents; Terpenes | 2001 |
Evaluation of synaptosomal uptake inhibition of most relevant constituents of St. John's wort.
Topics: Animals; Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Dopamine; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glutamic Acid; Hypericum; Male; Neurotransmitter Agents; Norepinephrine; Perylene; Phloroglucinol; Plant Extracts; Rats; Rats, Wistar; Serotonin; Synaptosomes; Terpenes | 2001 |
Batch-to-batch reproducibility of St. John's wort preparations.
Topics: Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Chemistry, Pharmaceutical; Humans; Hypericum; Perylene; Phloroglucinol; Phytotherapy; Plant Extracts; Reproducibility of Results; Terpenes | 2001 |
Pharmacological and endocrine effects of Hypericum perforatum and hypericin after repeated treatment.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Anthracenes; Antidepressive Agents; Antidepressive Agents, Tricyclic; Antioxidants; Biflavonoids; Catechin; Corticosterone; Endocrine System; Exploratory Behavior; Hypericum; Imipramine; Luteinizing Hormone; Male; Organ Size; Perylene; Pituitary Gland; Plant Extracts; Proanthocyanidins; Rats; Rats, Inbred Strains; Seminal Vesicles; Swimming | 2001 |
In vitro binding studies with two hypericum perforatum extracts--hyperforin, hypericin and biapigenin--on 5-HT6, 5-HT7, GABA(A)/benzodiazepine, sigma, NPY-Y1/Y2 receptors and dopamine transporters.
Topics: Animals; Anthracenes; Antidepressive Agents; Apigenin; Biflavonoids; Bridged Bicyclo Compounds; Dopamine Plasma Membrane Transport Proteins; Flavonoids; Hypericum; In Vitro Techniques; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Perylene; Phloroglucinol; Plant Extracts; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Neuropeptide Y; Receptors, Serotonin; Receptors, sigma; Terpenes | 2001 |
Interleukin-6 involvement in antidepressant action of Hypericum perforatum.
Topics: Administration, Oral; Animals; Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Diencephalon; Dose-Response Relationship, Drug; Hydroxyindoleacetic Acid; Hypericum; Immune System; Interleukin-6; Male; Mice; Mice, Knockout; Perylene; Phloroglucinol; Plant Extracts; Rutin; Serotonin; Swimming; Terpenes; Tryptophan | 2001 |
St John's wort, hypericin, and imipramine: a comparative analysis of mRNA levels in brain areas involved in HPA axis control following short-term and long-term administration in normal and stressed rats.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Anthracenes; Antidepressive Agents; Arginine Vasopressin; Brain; Brain-Derived Neurotrophic Factor; Corticosterone; Corticotropin-Releasing Hormone; Cyclic AMP Response Element-Binding Protein; Drug Administration Schedule; Glutamate Decarboxylase; Hippocampus; Hypericum; Hypothalamo-Hypophyseal System; Imipramine; In Situ Hybridization; Isoenzymes; Locus Coeruleus; Male; Paraventricular Hypothalamic Nucleus; Perylene; Pituitary Gland; Plants, Medicinal; Pro-Opiomelanocortin; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Reference Values; Restraint, Physical; RNA, Messenger; Stress, Psychological; Transcription, Genetic; Tyrosine 3-Monooxygenase | 2001 |
Variability in the content of the constituents of Hypericum perforatum L. and some commercial extracts.
Topics: Algorithms; Anthracenes; Antidepressive Agents; Chromatography, High Pressure Liquid; Drug Storage; Flavonoids; Hypericum; Parasympatholytics; Perylene; Phloroglucinol; Plant Extracts; Solvents; Sunlight | 2001 |
Catalytic inhibition of human DNA topoisomerase IIalpha by hypericin, a naphthodianthrone from St. John's wort (Hypericum perforatum).
Topics: Anthracenes; Antigens, Neoplasm; Catalysis; DNA Damage; DNA Fragmentation; DNA Topoisomerases, Type II; DNA-Binding Proteins; Drug Antagonism; Enzyme Inhibitors; HL-60 Cells; Humans; Hypericum; Isoenzymes; Perylene; Phytotherapy; Plants, Medicinal; Topoisomerase II Inhibitors | 2001 |
Development of a simple, rapid and reproducible HPLC assay for the simultaneous determination of hypericins and stabilized hyperforin in commercial St. John's wort preparations.
Topics: Anthracenes; Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Hypericum; Perylene; Phloroglucinol; Reproducibility of Results; Solutions; Terpenes | 2001 |
Chemical and pharmacological evaluation of Hypericum perforatum extracts.
Topics: Animals; Anthracenes; Antioxidants; Bridged Bicyclo Compounds; Free Radical Scavengers; Hippocampus; Hypericum; Male; Perylene; Phloroglucinol; Quercetin; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Terpenes | 2000 |
Separation of hypericins and hyperforins in extracts of Hypericum perforatum L. using non-aqueous capillary electrophoresis with reversed electro-osmotic flow.
Topics: Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Electrolytes; Electrophoresis, Capillary; Hypericum; Molecular Structure; Osmotic Pressure; Perylene; Phloroglucinol; Plant Extracts; Reproducibility of Results; Rheology; Solvents; Terpenes | 2002 |
Saint John's wort: an in vitro analysis of P-glycoprotein induction due to extended exposure.
Topics: Adenocarcinoma; Anthracenes; Antidepressive Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Blotting, Western; Caco-2 Cells; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Interactions; Drug Resistance, Multiple; Humans; Hypericum; Image Processing, Computer-Assisted; Microscopy, Fluorescence; Perylene; Protein Kinase C; Rhodamine 123; Ritonavir; Time Factors; Tumor Cells, Cultured; Verapamil | 2001 |
[Hyperici herba (Hypericum perforatum L].
Topics: Anthracenes; Drug Interactions; Hypericum; Molecular Structure; Perylene; Phytotherapy; Structure-Activity Relationship | 2001 |
[Experimental cultivation of Hypericum perforatum L. in Bratislava].
Topics: Anthracenes; Hypericum; Perylene; Plant Extracts; Plants, Medicinal | 2001 |
Phototoxic and apoptosis-inducing capacity of pseudohypericin.
Topics: Anthracenes; Apoptosis; Cell Division; DNA Fragmentation; Dose-Response Relationship, Drug; Humans; Hypericum; Jurkat Cells; Molecular Structure; Perylene | 2002 |
Long-term effects of St. John's wort and hypericin on monoamine levels in rat hypothalamus and hippocampus.
Topics: Animals; Anthracenes; Antidepressive Agents, Tricyclic; Biogenic Monoamines; Dopamine; Hippocampus; Hypericum; Hypothalamus; Imipramine; Kinetics; Male; Norepinephrine; Perylene; Rats; Serotonin | 2002 |
Short term treatment with St. John's wort, hypericin or hyperforin fails to induce CYP450 isoforms in the Swiss Webster mouse.
Topics: Alanine Transaminase; Animals; Anthracenes; Antidepressive Agents; Body Weight; Bridged Bicyclo Compounds; Cytochrome P-450 Enzyme System; Enzyme Induction; Hypericum; Isoenzymes; Liver; Male; Mice; Perylene; Phloroglucinol; Plant Preparations; Terpenes | 2002 |
Determining hyperforin and hypericin content in eight brands of St. John's wort.
Topics: Anthracenes; Anti-Bacterial Agents; Antidepressive Agents; Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Dosage Forms; Humans; Hypericum; Perylene; Phloroglucinol; Phytotherapy; Plant Extracts; Plants, Medicinal; Terpenes | 2002 |
The separation of hypericine and pseudohypericine from Hypericum perforatum L.
Topics: Anthracenes; Chromatography; Chromatography, Thin Layer; Countercurrent Distribution; Hypericum; Magnetic Resonance Spectroscopy; Methanol; Perylene; Solvents; Spectrophotometry, Ultraviolet; Ultrasonics | 2002 |
Severe phototoxic reaction to laser treatment in a patient taking St John's Wort.
Topics: Anthracenes; Antidepressive Agents; Dermatitis, Phototoxic; Face; Female; Humans; Hypericum; Keratosis; Laser Therapy; Leg; Middle Aged; Perylene; Phytotherapy; Plant Preparations; Plastic Surgery Procedures; Postoperative Complications; Radiation-Sensitizing Agents | 2001 |
Jasmonic acid-induced hypericin production in cell suspension cultures of Hypericum perforatum L. (St. John's wort).
Topics: Anthracenes; Cells, Cultured; Cyclopentanes; Hypericum; Oxylipins; Perylene | 2002 |
Simultaneous determination of hypericin and hyperforin in human plasma and serum using liquid-liquid extraction, high-performance liquid chromatography and liquid chromatography-tandem mass spectrometry.
Topics: Anthracenes; Bridged Bicyclo Compounds; Calibration; Chromatography, Liquid; Hypericum; Mass Spectrometry; Perylene; Phloroglucinol; Reproducibility of Results; Terpenes | 2002 |
An in vitro and hydroponic growing system for hypericin, pseudohypericin, and hyperforin production of St. John's wort (Hypericum perforatum CV new stem).
Topics: Anthracenes; Bridged Bicyclo Compounds; Culture Techniques; Environment, Controlled; Hydroponics; Hypericum; Perylene; Phloroglucinol; Plant Extracts; Terpenes | 2002 |
Clinic at the health food store? Employee recommendations and product analysis.
Topics: Anthracenes; Chromatography, High Pressure Liquid; Consumer Product Safety; Depression; Drug Labeling; Employee Performance Appraisal; Food, Organic; Health Knowledge, Attitudes, Practice; Humans; Hypericum; Perylene; Surveys and Questionnaires | 2003 |
[Dangerous interaction of St. John's wort with chemotherapy?].
Topics: Anthracenes; Antineoplastic Agents; Bridged Bicyclo Compounds; Drug Interactions; Humans; Hypericum; Perylene; Phloroglucinol; Terpenes | 2003 |
Mood-enhancing antidepressant St. John's wort inhibits the activation of human immunodeficiency virus gene expression by ultraviolet light.
Topics: Anthracenes; Antidepressive Agents; Butyrates; Chloramphenicol; Dose-Response Relationship, Drug; Gene Expression Regulation, Viral; Genes, Reporter; Ginkgo biloba; HeLa Cells; HIV; Humans; Hypericum; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Perylene; Time Factors; Transfection; Ultraviolet Rays | 2002 |
Dissolution, solubility and cooperativity of phenolic compounds from Hypericum perforatum L. in aqueous systems.
Topics: Anthracenes; Chemical Phenomena; Chemistry, Physical; Hypericum; Perylene; Phenols; Plant Extracts; Solubility; Water | 2003 |
Step by step removal of hyperforin and hypericin: activity profile of different Hypericum preparations in behavioral models.
Topics: Administration, Oral; Animals; Anthracenes; Antidepressive Agents; Behavior, Animal; Bridged Bicyclo Compounds; Female; Hypericum; Male; Mice; Mice, Inbred Strains; Motor Activity; Perylene; Phloroglucinol; Physical Exertion; Plant Extracts; Rats; Rats, Inbred Strains; Swimming; Terpenes | 2003 |
[Induction of callus of Hypericum perforatum L. and qualitative identification of active constituents of its callus].
Topics: Anthracenes; Culture Media; Culture Techniques; Hypericum; Perylene; Plant Leaves; Plants, Medicinal | 2001 |
Molecular and biochemical characterization of an enzyme responsible for the formation of hypericin in St. John's wort (Hypericum perforatum L.).
Topics: Amino Acid Sequence; Anthracenes; Base Sequence; Cells, Cultured; Chromatography, Liquid; DNA, Complementary; Hypericum; Mass Spectrometry; Molecular Sequence Data; Open Reading Frames; Perylene; Plant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Sequence Homology, Amino Acid | 2003 |
Hyperforin a constituent of St John's wort (Hypericum perforatum L.) extract induces apoptosis by triggering activation of caspases and with hypericin synergistically exerts cytotoxicity towards human malignant cell lines.
Topics: Annexin A5; Anthracenes; Antineoplastic Agents; Antioxidants; Apoptosis; Astrocytes; Biflavonoids; Bridged Bicyclo Compounds; Caspases; Catechin; Cell Division; Cell Line, Tumor; Cells, Cultured; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Humans; Hypericum; Perylene; Phloroglucinol; Plant Extracts; Proanthocyanidins; Terpenes | 2003 |
[Photometric determination of hypericin content in Hypericum].
Topics: Anthracenes; Hypericum; Perylene; Photometry; Plants | 1955 |
Analysis of the hypericin and pseudohypericin content of commercially available St John's Wort preparations.
Topics: Anthracenes; Antidepressive Agents; Canada; Capsules; Chromatography, Liquid; Hypericum; Perylene; Spectrometry, Fluorescence; Tablets; United States | 2003 |
Extracts of St. John's wort and various constituents affect beta-adrenergic binding in rat frontal cortex.
Topics: Animals; Anthracenes; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Bridged Bicyclo Compounds; Cell Membrane; Fluoxetine; Frontal Lobe; Hypericum; Imipramine; Male; Perylene; Phloroglucinol; Plant Extracts; Quercetin; Radioligand Assay; Rats; Receptors, Adrenergic, beta; Terpenes | 2004 |
Cytotoxic activity of Hypericum perforatum L. on K562 erythroleukemic cells: differential effects between methanolic extract and hypericin.
Topics: Anthracenes; Antineoplastic Agents, Phytogenic; Cell Survival; Flow Cytometry; Humans; Hypericum; K562 Cells; Perylene; Phytotherapy; Plant Extracts | 2004 |
Detection of hypericins in the "red glands" of Hypericum elodes by ESI-MS/MS.
Topics: Anthracenes; Flowers; Hypericum; Microscopy, Electron, Scanning; Perylene; Spectrometry, Mass, Electrospray Ionization | 2004 |
Induction of hypericins and hyperforins in Hypericum perforatum in response to damage by herbivores.
Topics: Adaptation, Physiological; Animals; Anthracenes; Anti-Bacterial Agents; Biological Assay; Bridged Bicyclo Compounds; Coleoptera; Enzyme Inhibitors; Feeding Behavior; Hypericum; Larva; Moths; Perylene; Phloroglucinol; Plants, Edible; Terpenes | 2003 |
Quantitative characterization of direct P-glycoprotein inhibition by St John's wort constituents hypericin and hyperforin.
Topics: Animals; Anthracenes; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bridged Bicyclo Compounds; Flow Cytometry; Genes, MDR; Herb-Drug Interactions; Humans; Hypericum; Mice; NIH 3T3 Cells; Perylene; Phloroglucinol; Terpenes | 2004 |
Determination of hypericin content in Hypericum triquetrifolium Turra (Hypericaceae) growing wild in Jordan.
Topics: Anthracenes; Calibration; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Hypericum; Jordan; Perylene; Plant Extracts | 2004 |
Inhibitory effect of the antidepressant St. John's wort (hypericum perforatum) on rat bladder contractility in vitro.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Anthracenes; Antidepressive Agents; Atropine; Bridged Bicyclo Compounds; Capsaicin; Depression; Electric Stimulation; Female; Haloperidol; Hypericum; Kaempferols; Male; Methysergide; Muscle Contraction; Muscle, Smooth; Naloxone; Perylene; Phentolamine; Phloroglucinol; Piperidines; Plant Extracts; Propranolol; Pyrazoles; Quercetin; Rats; Rats, Wistar; Rimonabant; Rutin; Terpenes; Tetrodotoxin; Urinary Bladder; Urinary Incontinence; Verapamil | 2004 |
[The influence of extraction method on the quality of the liquid extract of St John's wort].
Topics: Anthracenes; Antidepressive Agents; Drug Stability; Flavonoids; Humans; Hypericum; Perylene; Phytotherapy; Plant Extracts; Time Factors | 2004 |
Undeclared exposure to St. John's Wort in hospitalized patients.
Topics: Adult; Aged; Aged, 80 and over; Anthracenes; Bridged Bicyclo Compounds; Drug Interactions; Hospitalization; Humans; Hypericum; Middle Aged; Perylene; Phloroglucinol; Self Medication; Substance Abuse Detection; Terpenes | 2004 |
[Quantitative analysis of active substances in St. John's wort (Hypericum perforatum L.) by the high performance liquid chromatography method].
Topics: Anthracenes; Antidepressive Agents; Chromatography, High Pressure Liquid; Flavonoids; Humans; Hypericum; Perylene; Quercetin; Rutin; Time Factors | 2004 |
[Determining the quantity of hypericin in medicinal materials and asepsis seedings of Hypericum perforatum by HPLC].
Topics: Anthracenes; China; Chromatography, High Pressure Liquid; Ecosystem; Hypericum; Perylene; Plants, Medicinal; Quality Control; Seasons | 2003 |
[Effect of factors on callus biomass and synthetic mass of hypericin in Hypericum perforatum].
Topics: Anthracenes; Culture Media; Hypericum; Mannose; Nitrogen; Perylene; Plants, Medicinal; Povidone; Tissue Culture Techniques | 2003 |
Functional induction and de-induction of P-glycoprotein by St. John's wort and its ingredients in a human colon adenocarcinoma cell line.
Topics: Adenocarcinoma; Animals; Anthracenes; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Bridged Bicyclo Compounds; Cell Line, Tumor; Colonic Neoplasms; Digoxin; Humans; Hypericum; LLC-PK1 Cells; Perylene; Phloroglucinol; Plant Extracts; Rifampin; Swine; Terpenes; Transfection | 2005 |
Comparative chemical composition and variability of biological activity of methanolic extracts from Hypericum perforatum L.
Topics: Anthracenes; Chromatography, High Pressure Liquid; Hypericum; Methanol; Microbial Sensitivity Tests; Perylene; Plant Extracts; Quercetin; Rutin; Solvents | 2005 |
Liquid chromatography-mass spectrometry studies of St. John's wort methanol extraction: active constituents and their transformation.
Topics: Chromatography, High Pressure Liquid; Drug Stability; Gas Chromatography-Mass Spectrometry; Hydrogen-Ion Concentration; Hypericum; Light; Methanol; Molecular Structure; Perylene; Phloroglucinol; Plant Extracts | 2005 |
[Enhancement of hypericin production and cell growth of Hypericum perforatum L. suspension cultures by nitric oxide].
Topics: Anthracenes; Cells, Cultured; Hypericum; Nitric Oxide; Nitroprusside; Perylene; Phenylalanine Ammonia-Lyase; Plant Growth Regulators | 2005 |
Effects of the antidepressant St. John's wort (Hypericum perforatum) on rat and human vas deferens contractility.
Topics: Animals; Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Dose-Response Relationship, Drug; Ejaculation; Humans; Hypericum; Isometric Contraction; Male; Muscle, Smooth; Orgasm; Perylene; Phloroglucinol; Rats; Terpenes; Tissue Culture Techniques; Vas Deferens | 2005 |
Photogenotoxicity of hypericin in HaCaT keratinocytes: implications for St. John's Wort supplements and high dose UVA-1 therapy.
Topics: Anthracenes; Cells, Cultured; DNA Damage; Humans; Hypericum; Keratinocytes; Perylene; Phytotherapy; Ultraviolet Therapy | 2005 |
Identification and quantification of hypericin and pseudohypericin in different Hypericum perforatum L. in vitro cultures.
Topics: Anthracenes; Chromatography, High Pressure Liquid; Culture Techniques; Hypericum; Perylene; Plant Growth Regulators | 2005 |
Nitric oxide mediates the fungal elicitor-induced hypericin production of Hypericum perforatum cell suspension cultures through a jasmonic-acid-dependent signal pathway.
Topics: Anthracenes; Aspergillus niger; Cells, Cultured; Cyclopentanes; Fungal Proteins; Hypericum; Nitric Oxide; Oxylipins; Perylene; Plant Growth Regulators; Signal Transduction | 2005 |
Photoinduced antitumour effect of hypericin can be enhanced by fractionated dosing.
Topics: Animals; Anthracenes; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Drug Administration Schedule; Fibrosarcoma; Hypericum; Injections, Intraperitoneal; Light; Male; Mice; Mice, Inbred Strains; Perylene; Photochemotherapy; Photosensitizing Agents; Phytotherapy | 2005 |
Content analysis and stability evaluation of selected commercial preparations of St. John's wort.
Topics: Anthracenes; Antidepressive Agents; Capsules; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Drug Stability; Environment; Hardness; Humidity; Hypericum; Indicators and Reagents; Perylene; Reference Standards; Reproducibility of Results; Solvents; Spectrophotometry, Ultraviolet; Tablets; Temperature | 2005 |
Can St John's wort (hypericin) ingestion enhance the erythemal response during high-dose ultraviolet A1 therapy?
Topics: Adult; Anthracenes; Antidepressive Agents; Dose-Response Relationship, Radiation; Erythema; Humans; Hypericum; Middle Aged; Perylene; Phytotherapy; Plant Extracts; Radiation Injuries; Radiotherapy Dosage; Severity of Illness Index; Ultraviolet Therapy | 2005 |
Quantitative analysis of the major constituents of St John's wort with HPLC-ESI-MS.
Topics: Anthracenes; Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Hypericum; Perylene; Phloroglucinol; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Terpenes | 2005 |
Approach to novel functional foods for stress control 4. Regulation of serotonin transporter by food factors.
Topics: Animals; Anthracenes; Biflavonoids; Bridged Bicyclo Compounds; Carrier Proteins; Cell Differentiation; Cell Line; Cell Lineage; Cells, Cultured; Fluoxetine; Fluvoxamine; Food; Hypericum; Ligands; Macrophages; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Osteoclasts; Perylene; Phloroglucinol; Plant Extracts; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Recombinant Proteins; Serotonin; Stress, Physiological; Terpenes; Time Factors | 2005 |
Photophysical properties of Hypericum perforatum L. extracts--novel photosensitizers for PDT.
Topics: Anthracenes; Hydrogen-Ion Concentration; Hypericum; Methanol; Perylene; Photochemistry; Photochemotherapy; Photosensitizing Agents; Plant Extracts; Spectrometry, Fluorescence | 2006 |
Genetic and biochemical analysis of Hypericum perforatum L. plants regenerated after cryopreservation.
Topics: Anthracenes; Chromosomes, Plant; Cryopreservation; DNA, Plant; Hypericum; Karyotyping; Perylene; Plant Shoots; Regeneration; Seedlings; Tissue Culture Techniques | 2006 |
Development and evaluation of methods for determination of naphthodianthrones and flavonoids in St. John's wort.
Topics: Anthracenes; Chemical Fractionation; Chromatography, Liquid; Flavonoids; Hypericum; Mass Spectrometry; Perylene | 2006 |
Induction of hypericins in Hypericum perforatum in response to chromium.
Topics: Analysis of Variance; Anthracenes; Chromium; Gene Expression Regulation; Hypericum; Perylene; Plants, Medicinal; Seedlings | 2006 |
Comparison of methods for the exhaustive extraction of hypericins, flavonoids, and hyperforin from Hypericum perforatum L.
Topics: Anthracenes; Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Flavonoids; Hypericum; Mass Spectrometry; Perylene; Phloroglucinol; Sonication; Terpenes | 2006 |
Reduction in hypericin-induced phototoxicity by Hypericum perforatum extracts and pure compounds.
Topics: Anthracenes; Cell Line; Cell Proliferation; Humans; Hypericum; Oxidation-Reduction; Perylene; Photochemistry; Plant Extracts | 2006 |
Plant-environment interactions: Accumulation of hypericin in dark glands of Hypericum perforatum.
Topics: Anthracenes; Ecosystem; Flowers; Hypericum; Light; Molecular Structure; Perylene; Photosynthesis; Plant Leaves; Plant Shoots; Plant Stems | 2006 |
Expression of the hyp-1 gene in early stages of development of Hypericum perforatum L.
Topics: Anthracenes; DNA, Complementary; Gene Expression; Genes, Plant; Hypericum; Peptide Elongation Factor 1; Perylene; Plant Leaves; Plant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Plant | 2007 |
[Sunburn -- or yet not?].
Topics: Aged; Aged, 80 and over; Anthracenes; Dermatitis, Contact; Diagnosis, Differential; Humans; Hypericum; Male; Perylene; Sunburn | 2006 |
[Evaluation of preparing process of extract of hypericum perforatum using HPLC fingerprint analysis].
Topics: Anthracenes; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Flavonoids; Hypericum; Perylene; Plant Components, Aerial; Plants, Medicinal; Quality Control; Quercetin; Rutin; Technology, Pharmaceutical | 2006 |
Variation in the content of hypericins in four generations of seed progeny of Hypericum perforatum somaclones.
Topics: Anthracenes; Base Sequence; Chromosomes, Plant; DNA Primers; DNA, Plant; Genetic Variation; Hypericum; Minisatellite Repeats; Perylene; Polymerase Chain Reaction; Seeds | 2007 |
Histomorphological changes in murine fibrosarcoma after hypericin-based photodynamic therapy.
Topics: Animals; Anthracenes; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Disease Models, Animal; Fibrosarcoma; Humans; Hypericum; Injections, Intraperitoneal; Male; Mice; Mice, Inbred C3H; Perylene; Photochemotherapy; Photosensitizing Agents; Phytotherapy; Plant Extracts; Radiation Dosage | 2007 |
Antiinflammatory activity of ethanol extracts of Hypericum perforatum L., H. barbatum Jacq., H. hirsutum L., H. richeri Vill. and H. androsaemum L. in rats.
Topics: Animals; Anthracenes; Anti-Inflammatory Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Ethanol; Hypericum; Indomethacin; Perylene; Plant Extracts; Rats | 2007 |
The production of hypericins in two selected Hypericum perforatum shoot cultures is related to differences in black gland structure.
Topics: Anthracenes; Cells, Cultured; Hypericum; Microscopy, Electron, Scanning; Perylene; Plant Leaves; Plant Shoots | 2007 |
A mechanistic study on altered pharmacokinetics of irinotecan by St. John's wort.
Topics: Animals; Anthracenes; Antineoplastic Agents, Phytogenic; Bridged Bicyclo Compounds; Camptothecin; Cell Line, Tumor; Cell Proliferation; Glucuronides; Hypericum; Irinotecan; Male; Microsomes, Liver; Perylene; Phloroglucinol; Plant Extracts; Quercetin; Rats; Rats, Sprague-Dawley; Terpenes | 2007 |
[The development of secondary cells in the callus of Hypericum perforatum L. and hypericins accumulation].
Topics: Anthracenes; Chromatography, High Pressure Liquid; Hypericum; Microscopy, Electron, Transmission; Molecular Structure; Perylene; Tissue Culture Techniques | 2007 |
The main components of St John's Wort inhibit low-density lipoprotein atherogenic modification: a beneficial "side effect" of an OTC antidepressant drug?
Topics: Anthracenes; Antidepressive Agents; Antioxidants; Atherosclerosis; Bridged Bicyclo Compounds; Cells, Cultured; Chromatography, High Pressure Liquid; Circular Dichroism; Depression; Drug Evaluation, Preclinical; Endothelial Cells; Humans; Hypericum; Lipoproteins, LDL; Malondialdehyde; Mass Spectrometry; Molecular Structure; Nonprescription Drugs; Oxidation-Reduction; Peroxidase; Perylene; Phloroglucinol; Phytotherapy; Protein Binding; Structure-Activity Relationship; Terpenes; Thiobarbituric Acid Reactive Substances; Thromboplastin; Tyrosine; Umbilical Veins | 2007 |
Topical anti-inflammatory activity of extracts and compounds from Hypericum perforatum L.
Topics: Administration, Topical; Animals; Anthracenes; Anti-Inflammatory Agents; Bridged Bicyclo Compounds; Croton Oil; Dose-Response Relationship, Drug; Edema; Flavonoids; Flowers; Hypericum; Inhibitory Concentration 50; Male; Mice; Perylene; Phloroglucinol; Phytotherapy; Plant Extracts; Plants, Medicinal; Terpenes | 2007 |
Variability in PXR-mediated induction of CYP3A4 by commercial preparations and dry extracts of St. John's wort.
Topics: Anthracenes; Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Constitutive Androstane Receptor; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Flavonoids; Humans; Hypericum; Perylene; Phloroglucinol; Plant Extracts; Pregnane X Receptor; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Response Elements; Tablets; Terpenes; Transcription Factors; Transfection; Tumor Cells, Cultured | 2007 |
Hypericin and hyperforin production in St. John's wort in vitro culture: influence of saccharose, polyethylene glycol, methyl jasmonate, and Agrobacterium tumefaciens.
Topics: Acetates; Agrobacterium tumefaciens; Anthracenes; Bridged Bicyclo Compounds; Cyclopentanes; Hypericum; Oxylipins; Perylene; Phloroglucinol; Polyethylene Glycols; Seeds; Sucrose; Terpenes | 2007 |
Drug-herb interaction: effect of St John's wort on bioavailability and metabolism of procainamide in mice.
Topics: Acecainide; Animals; Anthracenes; Biological Availability; Female; Herb-Drug Interactions; Hypericum; Mice; Perylene; Procainamide | 2007 |
[Morphological identification of 20 medicinal species in Hypericum].
Topics: Anthracenes; Flowers; Fruit; Hypericum; Oils, Volatile; Perylene; Plant Leaves; Plant Stems; Plants, Medicinal; Species Specificity | 2007 |
Inhibition of prostaglandin E(2) production by anti-inflammatory hypericum perforatum extracts and constituents in RAW264.7 Mouse Macrophage Cells.
Topics: Animals; Anti-Inflammatory Agents; Bridged Bicyclo Compounds; Cell Death; Cells, Cultured; Dinoprostone; Flavonoids; Hypericum; Light; Macrophages; Mice; Perylene; Phloroglucinol; Plant Extracts; Terpenes | 2007 |
Influence of the developmental stage on the (proto)-hypericin and (proto)pseudohypericin levels of Hypericum plants from Crete.
Topics: Anthracenes; Antidepressive Agents; Flowers; Greece; Hypericum; Perylene; Plant Leaves; Plants, Medicinal; Seasons; Species Specificity | 2007 |
1H NMR determination of hypericin and pseudohypericin in complex natural mixtures by the use of strongly deshielded OH groups.
Topics: Anthracenes; Chromatography, Liquid; Hydrogen Bonding; Hypericum; Mass Spectrometry; Nuclear Magnetic Resonance, Biomolecular; Perylene; Plant Extracts; Spectrophotometry, Ultraviolet | 2008 |
An endophytic fungus from Hypericum perforatum that produces hypericin.
Topics: Anthracenes; Aspergillus niger; Candida albicans; DNA, Fungal; Gram-Negative Bacteria; Gram-Positive Bacteria; Hypericum; Microbial Sensitivity Tests; Molecular Structure; Perylene | 2008 |
Protective effects of St. John's wort extract and its component hyperforin against cytokine-induced cytotoxicity in a pancreatic beta-cell line.
Topics: Animals; Anthracenes; Antineoplastic Agents; Apoptosis; Bridged Bicyclo Compounds; Cell Line, Tumor; Humans; Hypericum; Insulin; Insulin Secretion; Insulin-Secreting Cells; Interferon-gamma; Interleukin-1beta; Male; NF-kappa B; Nitric Oxide Synthase Type II; Perylene; Phloroglucinol; Plant Extracts; Rats; Rats, Sprague-Dawley; STAT1 Transcription Factor; Terpenes; Tumor Necrosis Factor-alpha | 2008 |
Hypericin inhibits pathological retinal neovascularization in a mouse model of oxygen-induced retinopathy.
Topics: Angiogenesis Inhibitors; Animals; Anthracenes; Disease Models, Animal; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Female; Hypericum; Ischemia; Mice; Mice, Inbred C57BL; Neovascularization, Physiologic; Oxygen; Perylene; Phosphorylation; Retina; Retinal Diseases; Retinal Neovascularization | 2008 |
Antiinflammatory and antioxidant activity of Hypericum rumeliacum Boiss. subsp. apollinis (Boiss. & Heldr.) Robson & Strid methanol extract.
Topics: Animals; Anthracenes; Anti-Inflammatory Agents; Antioxidants; Chlorogenic Acid; Chondrus; Chromatography, High Pressure Liquid; Edema; Flavonoids; Hindlimb; Hypericum; Male; Methanol; Perylene; Phenols; Plant Components, Aerial; Plant Extracts; Polyphenols; Quercetin; Rats; Rats, Wistar; Rutin | 2008 |
Crystallization and preliminary crystallographic studies of Hyp-1, a St John's wort protein implicated in the biosynthesis of hypericin.
Topics: Amino Acid Sequence; Anthracenes; Cloning, Molecular; Crystallization; Crystallography, X-Ray; Hypericum; Molecular Sequence Data; Perylene; Plant Proteins; Sequence Homology, Amino Acid | 2008 |
Bioactive constituent production in St. John's Wort in vitro hairy roots. Regenerated plant lines.
Topics: Anthracenes; Bridged Bicyclo Compounds; Chlorogenic Acid; Hypericum; Perylene; Phloroglucinol; Plant Extracts; Plant Roots; Plants, Genetically Modified; Terpenes; Transformation, Genetic | 2008 |
Octaketide-producing type III polyketide synthase from Hypericum perforatum is expressed in dark glands accumulating hypericins.
Topics: Anthracenes; Base Sequence; Chromatography, Liquid; DNA Primers; Escherichia coli; Hypericum; In Situ Hybridization; Molecular Sequence Data; Perylene; Phylogeny; Polyketide Synthases; Recombinant Proteins; RNA Probes; Spectrometry, Mass, Electrospray Ionization | 2008 |
Influence of the habitat altitude on the (proto)hypericin and (proto)pseudohypericin levels of hypericum plants from Crete.
Topics: Acclimatization; Altitude; Chromatography, High Pressure Liquid; Flowers; Geography; Greece; Hypericum; Light; Perylene; Plant Leaves; Species Specificity; Ultraviolet Rays | 2008 |
Signal interaction between nitric oxide and hydrogen peroxide in heat shock-induced hypericin production of Hypericum perforatum suspension cells.
Topics: Anthracenes; Antidepressive Agents; Cells, Cultured; Enzyme Inhibitors; Heat-Shock Response; Humans; Hydrogen Peroxide; Hypericum; Nitric Oxide; Nitric Oxide Synthase; Oxidants; Perylene; Signal Transduction | 2008 |
Pseudohypericin is necessary for the light-activated inhibition of prostaglandin E2 pathways by a 4 component system mimicking an Hypericum perforatum fraction.
Topics: Animals; Cell Line; Chlorogenic Acid; Dinoprostone; Ethanol; Hypericum; Light; Macrophages; Mice; Perylene; Plant Extracts; Quercetin; Rutin | 2008 |
Pseudohypericin and hyperforin in Hypericum perforatum from Northern Turkey: variation among populations, plant parts and phenological stages.
Topics: Bridged Bicyclo Compounds; Climate; Geography; Hypericum; Perylene; Phloroglucinol; Plant Leaves; Plant Stems; Plant Structures; Population Dynamics; Seasons; Terpenes; Turkey | 2008 |
Effects of different concentrations of benzylaminopurine on shoot regeneration and hypericin content in Hypericum triquetrifolium Turra.
Topics: Anthracenes; Benzyl Compounds; Germination; Hypericum; Perylene; Plant Shoots; Purines; Regeneration | 2009 |
Variation of hypericins in Hypericum triquetrifolium Turra growing in different locations of Turkey during plant growth.
Topics: Anthracenes; Hypericum; Perylene; Plants, Medicinal; Turkey | 2008 |
Involvement of serotoninergic 5-HT1A/2A, alpha-adrenergic and dopaminergic D1 receptors in St. John's wort-induced prepulse inhibition deficit: a possible role of hyperforin.
Topics: Animals; Anthracenes; Apoptosis; Bridged Bicyclo Compounds; DNA Fragmentation; Drugs, Chinese Herbal; Hypericum; Inhibition, Psychological; Male; Mice; Perylene; Phloroglucinol; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Receptors, Dopamine D1; Reflex, Acoustic; Reflex, Startle; Serotonin 5-HT1 Receptor Antagonists; Serotonin 5-HT2 Receptor Antagonists; Terpenes | 2009 |
Impact of the haplotypes of the human pregnane X receptor gene on the basal and St John's wort-induced activity of cytochrome P450 3A4 enzyme.
Topics: Anthracenes; Area Under Curve; Bridged Bicyclo Compounds; Cytochrome P-450 CYP3A; Female; Haplotypes; Humans; Hypericum; Male; Perylene; Phloroglucinol; Plant Preparations; Pregnane X Receptor; Receptors, Steroid; Terpenes; Young Adult | 2009 |
Rapid and efficient purification of naphthodianthrones from St. John's wort extract by using liquid-liquid extraction and SEC.
Topics: Acetates; Anthracenes; Chromatography, Gel; Dextrans; Enzyme Inhibitors; Hexanes; Hypericum; Magnetic Resonance Spectroscopy; Mass Spectrometry; Methanol; Perylene; Plant Extracts; Solvents; Water | 2009 |
Positive correlations between hypericin and putative precursors detected in the quantitative secondary metabolite spectrum of Hypericum.
Topics: Anthracenes; Chromatography, Liquid; Discriminant Analysis; Emodin; Hypericum; Multivariate Analysis; Perylene; Principal Component Analysis; Tandem Mass Spectrometry | 2009 |
Study of dynamic accumulation of secondary metabolites in three subspecies of Hypericum perforatum.
Topics: Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Flavonoids; Flowers; Hypericum; Perylene; Phloroglucinol; Plant Extracts; Plant Leaves; Reference Standards; Species Specificity; Terpenes | 2010 |
Chemical constituents and antidepressant activity of the new species Hypericum enshiense occurring in China.
Topics: Animals; Anthracenes; Antidepressive Agents; Behavior, Animal; China; Depression; Disease Models, Animal; Flavonoids; Hindlimb Suspension; Hypericum; Male; Mice; Mice, Inbred Strains; Motor Activity; Perylene; Phytotherapy; Plant Components, Aerial; Plant Extracts; Swimming | 2010 |
Chemical constituents of Hypericum adenotrichum Spach, an endemic Turkish species.
Topics: Anthracenes; Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Hypericum; Kaempferols; Perylene; Phloroglucinol; Quercetin; Terpenes; Turkey | 2009 |
Light-independent metabolomics of endophytic Thielavia subthermophila provides insight into microbial hypericin biosynthesis.
Topics: Anthracenes; Antineoplastic Agents; Base Sequence; Drug Screening Assays, Antitumor; Emodin; Humans; Hypericum; Light; Metabolomics; Molecular Structure; Perylene; Sordariales | 2009 |
Crystal structure of Hyp-1, a St. John's wort protein implicated in the biosynthesis of hypericin.
Topics: Anthracenes; Antidepressive Agents; Crystallization; Dimerization; Emodin; Hypericum; Models, Molecular; Molecular Structure; Perylene; Plant Proteins; Protein Conformation | 2010 |
The association between self-reported cataracts and St. John's Wort.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Anthracenes; Cataract; Depression; Female; Humans; Hypericum; Lens, Crystalline; Male; Middle Aged; Perylene; Sex Factors; Surveys and Questionnaires; White People | 2009 |
A prolonged protein kinase C-mediated, opioid-related antinociceptive effect of st John's Wort in mice.
Topics: Acetic Acid; Analgesics; Analgesics, Opioid; Animals; Anthracenes; Chromatography, High Pressure Liquid; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Administration Schedule; Drug Compounding; Hypericum; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Pain Threshold; Perylene; Phorbol Esters; Phytotherapy; Protein Kinase C; Quercetin; Somatostatin; Spectrometry, Mass, Electrospray Ionization; Statistics, Nonparametric; Time Factors | 2010 |
St. John's Wort reduces neuropathic pain through a hypericin-mediated inhibition of the protein kinase Cgamma and epsilon activity.
Topics: Analgesics; Animals; Anthracenes; Hypericum; Male; Pain; Perylene; Phytotherapy; Plant Extracts; Protein Kinase C; Protein Kinase C-epsilon; Rats; Rats, Sprague-Dawley | 2010 |
Hypericin, the active component of St. John's wort, inhibits glutamate release in the rat cerebrocortical synaptosomes via a mitogen-activated protein kinase-dependent pathway.
Topics: Animals; Anthracenes; Cerebral Cortex; Dose-Response Relationship, Drug; Glutamic Acid; Hypericum; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Perylene; Rats; Rats, Sprague-Dawley; Synaptosomes | 2010 |
Effect of St. John's Wort standardized extract and hypericin on in vitro placental calcium transport.
Topics: Anthracenes; Biological Transport; Calcium; Cell Line; Cell Survival; Female; Humans; Hypericum; Perylene; Placenta; Plant Extracts; Pregnancy; Trophoblasts | 2010 |
Secondary metabolites of Hypericum confertum and their possible chemotaxonomic significance.
Topics: Anthracenes; Apigenin; Biflavonoids; Bridged Bicyclo Compounds; Chlorogenic Acid; Hypericum; Perylene; Phloroglucinol; Plant Components, Aerial; Quercetin; Rutin; Terpenes | 2010 |
Pharmacological studies on Hypericum perforatum fractions and constituents.
Topics: Animals; Anthracenes; Calcium; Calcium Channel Blockers; Dose-Response Relationship, Drug; Female; Guinea Pigs; Hypericum; In Vitro Techniques; Male; Perylene; Phloroglucinol; Phosphodiesterase Inhibitors; Plant Extracts; Quercetin; Rabbits; Terpenes; Verapamil | 2011 |
Inhibition of 17β-estradiol activation by CYP1A1: genotype- and regioselective inhibition by St. John's Wort and several natural polyphenols.
Topics: Amino Acid Substitution; Anthracenes; Anti-Inflammatory Agents, Non-Steroidal; Biocatalysis; Cytochrome P-450 CYP1A1; Dose-Response Relationship, Drug; Estradiol; Flavonoids; Flavonols; Genotype; Humans; Hydroxylation; Hypericum; Perylene; Phenols; Plant Extracts; Polyphenols; Quercetin; Recombinant Proteins; Resveratrol; Stereoisomerism; Stilbenes; Substrate Specificity | 2011 |
Isolation and purification of series bioactive components from Hypericum perforatum L. by counter-current chromatography.
Topics: Anthracenes; Bridged Bicyclo Compounds; Chemical Fractionation; Chromatography, High Pressure Liquid; Countercurrent Distribution; Flavonols; Hypericum; Mass Spectrometry; Nuclear Magnetic Resonance, Biomolecular; Perylene; Phloroglucinol; Plant Extracts; Terpenes | 2011 |
Enhancing hypericin production of Hypericum perforatum cell suspension culture by ozone exposure.
Topics: Anthracenes; Cells, Cultured; Hypericum; Ozone; Perylene | 2011 |
Hypericin and pseudohypericin concentrations of a valuable medicinal plant Hypericum perforatum L. are enhanced by arbuscular mycorrhizal fungi.
Topics: Anthracenes; Glomeromycota; Hypericum; Mycorrhizae; Perylene; Plants, Medicinal | 2012 |
In vitro photochemical and phototoxicological characterization of major constituents in St. John's Wort (Hypericum perforatum) extracts.
Topics: Anthracenes; Antidepressive Agents; Biological Products; Dermatitis, Phototoxic; DNA Damage; Enzyme Inhibitors; Hypericum; Light; Lipid Peroxidation; Perylene; Phloroglucinol; Plant Extracts; Reactive Oxygen Species; Terpenes | 2011 |
Flavonoid glycosides and naphthodianthrones in the sawfly Tenthredo zonula and its host-plants, Hypericum perforatum and H. hirsutum.
Topics: Animals; Anthracenes; Flavonoids; Glycosides; Host-Parasite Interactions; Hymenoptera; Hypericum; Larva; Perylene | 2011 |
Identification of anti-inflammatory constituents in Hypericum perforatum and Hypericum gentianoides extracts using RAW 264.7 mouse macrophages.
Topics: Animals; Anti-Inflammatory Agents; Cells, Cultured; Chemical Fractionation; Chromatography, Liquid; Dinoprostone; Hypericum; Macrophages; Mass Spectrometry; Mice; Nitric Oxide; Perylene; Plant Extracts | 2011 |
[Study on the enzyme extraction process of hypericin by pectinase].
Topics: Analysis of Variance; Anthracenes; Chromatography, High Pressure Liquid; Dextranase; Hydrogen-Ion Concentration; Hypericum; Perylene; Plant Components, Aerial; Plants, Medicinal; Polygalacturonase; Reproducibility of Results; Technology, Pharmaceutical; Temperature; Time Factors | 2011 |
The inhibition of lipopolysaccharide-induced macrophage inflammation by 4 compounds in Hypericum perforatum extract is partially dependent on the activation of SOCS3.
Topics: Animals; Anti-Inflammatory Agents; Biflavonoids; Cell Line; Chlorogenic Acid; Cytokines; Dinoprostone; Ethanol; Gene Knockdown Techniques; Hypericum; Inflammation; Inflammation Mediators; Lipopolysaccharides; Macrophages; Mice; Nitric Oxide; Perylene; Quercetin; RNA, Small Interfering; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins; Transcription, Genetic; Transfection | 2012 |
Investigating the effectiveness of St John's wort herb as an antimicrobial agent against mycobacteria.
Topics: Anthracenes; Anti-Bacterial Agents; Hypericum; Microbial Sensitivity Tests; Microscopy, Electron, Scanning; Mycobacterium; Perylene; Phloroglucinol; Plant Extracts; Terpenes | 2012 |
Content of hypericins from plants and in vitro shoots of Hypericum undulatum Schousb. ex Willd.
Topics: Anthracenes; Chromatography, High Pressure Liquid; Hypericum; Molecular Structure; Perylene; Plant Shoots | 2013 |
Secondary metabolites of Hypericum leptophyllum Hochst., an endemic Turkish species.
Topics: Anthracenes; Chlorogenic Acid; Chromatography, High Pressure Liquid; Flavonoids; Hypericum; Perylene; Phloroglucinol; Plant Components, Aerial; Plant Leaves; Plant Stems; Terpenes; Turkey | 2012 |
Evaluation of the in vitro inhibitory impact of hypericin on placental glutathione S-transferase pi.
Topics: Anthracenes; Dinitrochlorobenzene; Electrophoresis, Polyacrylamide Gel; Female; Glutathione; Glutathione S-Transferase pi; Humans; Hypericum; Kinetics; Perylene; Placenta; Pregnancy; Substrate Specificity | 2012 |
[Rapid cloning and functional characterization of hypericin synthase gene].
Topics: Anthracenes; Antidepressive Agents; Antiviral Agents; Chemistry Techniques, Synthetic; Emodin; Escherichia coli; Gene Expression Regulation, Plant; Genes, Plant; Genetic Vectors; Hypericum; Peptide Synthases; Perylene; Plant Proteins; Plants, Medicinal; Recombinant Proteins; Transformation, Genetic | 2012 |
Elicitation of secondary metabolism in Hypericum perforatum by rhizosphere bacteria and derived elicitors in seedlings and shoot cultures.
Topics: Anthracenes; Bacteria; Chromatography, High Pressure Liquid; Culture Media; Hypericum; Perylene; Plant Shoots; Rhizosphere; Seedlings; Tissue Culture Techniques | 2012 |
Hypericin-PDT-induced rapid necrotic death in human squamous cell carcinoma cultures after multiple treatment.
Topics: Anthracenes; Carcinoma, Squamous Cell; Cell Line, Tumor; Humans; Hypericum; Necrosis; Perylene; Photochemotherapy; Reactive Oxygen Species; Skin Neoplasms | 2012 |
Effects of St John's wort and its active constituents, hypericin and hyperforin, on isolated rat urinary bladder.
Topics: Animals; Anthracenes; Carbachol; Cell Membrane; Dose-Response Relationship, Drug; Electric Stimulation; Glucose; Hypericum; Hypoxia; Ischemia; Male; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Parasympathomimetics; Perylene; Phloroglucinol; Plant Extracts; Potassium Chloride; Rats; Rats, Sprague-Dawley; Terpenes; Urinary Bladder; Urinary Bladder Diseases; Urinary Bladder, Overactive | 2012 |
Preparation of a polyclonal antibody against hypericin synthase and localization of the enzyme in red-pigmented Hypericum perforatum L. plantlets.
Topics: Animals; Anthracenes; Antibodies; Antidepressive Agents; Hypericum; Peptide Synthases; Perylene; Plant Extracts; Plant Stems; Rabbits | 2012 |
PAL inhibitor evokes different responses in two Hypericum species.
Topics: Amino Acids; Anthracenes; Chlorogenic Acid; Hypericum; Indans; Organophosphonates; Perylene; Phenols; Phenylalanine Ammonia-Lyase | 2013 |
Reversal of NO-induced nociceptive hypersensitivity by St. John's wort and hypericin: NF-κB, CREB and STAT1 as molecular targets.
Topics: Animals; Anthracenes; Cold Temperature; CREB-Binding Protein; Hot Temperature; Hyperalgesia; Hypericum; Male; Mice; NF-kappa B; Nitric Oxide; Nitric Oxide Donors; Pain Measurement; Perylene; Plant Extracts; Protein Kinase C; Random Allocation; STAT1 Transcription Factor | 2013 |
Changes in the contents of main secondary metabolites in two Turkish Hypericum species during plant development.
Topics: Chromatography, High Pressure Liquid; Cinnamates; Ethnobotany; Flavonols; Flowers; Hypericum; Perylene; Plant Extracts; Plant Leaves; Plant Stems; Spatio-Temporal Analysis; Species Specificity; Spectrophotometry, Ultraviolet; Terpenes; Turkey | 2013 |
Effect of hypericin on the ADAMTS-9 and ADAMTS-8 gene expression in MCF7 breast cancer cells.
Topics: ADAM Proteins; ADAMTS Proteins; ADAMTS9 Protein; Anthracenes; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Coloring Agents; Female; Gene Expression Regulation, Neoplastic; Humans; Hypericum; Perylene; Real-Time Polymerase Chain Reaction; RNA, Neoplasm; Tetrazolium Salts | 2013 |
Hypericin-loaded lipid nanocapsules for photodynamic cancer therapy in vitro.
Topics: Anthracenes; Cell Line; Cell Survival; Drug Carriers; HeLa Cells; Humans; Hypericum; Light; Lipids; Microscopy, Video; Nanocapsules; Neoplasms; Particle Size; Perylene; Photochemotherapy; Photosensitizing Agents; Singlet Oxygen; Spectrophotometry, Ultraviolet | 2013 |
St. John's Wort seed and feverfew flower extracts relieve painful diabetic neuropathy in a rat model of diabetes.
Topics: Animals; Anthracenes; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Flowers; Hyperalgesia; Hypericum; Perylene; Phloroglucinol; Phytotherapy; Plant Components, Aerial; Plant Extracts; Rats; Seeds; Sesquiterpenes; Tanacetum parthenium; Terpenes | 2014 |
Interaction between different extracts of Hypericum perforatum L. from Serbia and pentobarbital, diazepam and paracetamol.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anthracenes; Anti-Anxiety Agents; Capsules; Diazepam; Female; Herb-Drug Interactions; Hypericum; Male; Mice; Motor Activity; Pentobarbital; Perylene; Plant Extracts; Plants, Medicinal; Serbia; Solvents; Tablets | 2014 |
PKC-mediated potentiation of morphine analgesia by St. John's Wort in rodents and humans.
Topics: Administration, Oral; Analgesia; Analgesics, Opioid; Animals; Anthracenes; Drug Synergism; Enzyme Inhibitors; Hot Temperature; Humans; Hypericum; Male; Mice; Morphine; Nociception; Pain Measurement; Periaqueductal Gray; Perylene; Phosphorylation; Plant Extracts; Protein Kinase C | 2014 |
[Chemical constituents of ethyl acetate fraction from Hypericum hengshanense].
Topics: Acetates; Anthracenes; Hypericum; Kaempferols; Magnetic Resonance Spectroscopy; Perylene; Plant Components, Aerial; Plants, Medicinal; Quercetin; Rutin | 2013 |
Hypericum perforatum: Influences of the habitat on chemical composition, photo-induced cytotoxicity, and antiradical activity.
Topics: Altitude; Animals; Anthracenes; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Cell Line, Tumor; Cell Survival; Ecosystem; Free Radical Scavengers; Humans; Hypericum; Italy; Mice; Nitric Oxide; Perylene; Phenols; Photosensitizing Agents; Plant Components, Aerial; Plant Extracts; Rutin | 2014 |
Molecularly imprinted polymer for specific extraction of hypericin from Hypericum perforatum L. herbal extract.
Topics: Acetone; Acrylamide; Acrylates; Adsorption; Anthracenes; Binding Sites; Chromatography, High Pressure Liquid; Herbal Medicine; Hydrogen Bonding; Hypericum; Liquid-Liquid Extraction; Molecular Imprinting; Perylene; Plant Extracts; Polymers; Propylene Glycols; Solid Phase Extraction | 2014 |
Single pre-treatment with hypericin, a St. John's wort secondary metabolite, attenuates cisplatin- and mitoxantrone-induced cell death in A2780, A2780cis and HL-60 cells.
Topics: Anthracenes; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Cell Death; Cell Line, Tumor; Cisplatin; Drug Interactions; Humans; Hypericum; Mitoxantrone; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Perylene; RNA, Messenger | 2014 |
St John's Wort (Hypericum perforatum L.) photomedicine: hypericin-photodynamic therapy induces metastatic melanoma cell death.
Topics: Anthracenes; Apoptosis; Apoptosis Regulatory Proteins; Cell Line, Tumor; Cell Size; Drug Screening Assays, Antitumor; Endoplasmic Reticulum; Female; Humans; Hypericum; Melanoma; Middle Aged; Perylene; Photochemotherapy; Photosensitizing Agents; Pigmentation; Skin Neoplasms; Transcriptional Activation | 2014 |
Effects of UV-B radiation on total phenolic, flavonoid and hypericin contents in Hypericum retusum Aucher grown under in vitro conditions.
Topics: Anthracenes; Benzyl Compounds; Flavonoids; Hypericum; In Vitro Techniques; Kinetin; Perylene; Phenols; Purines; Ultraviolet Rays | 2014 |
Hypericin biosynthesis in Hypericum hookerianum Wight and Arn: investigation on biochemical pathways using metabolite inhibitors and suppression subtractive hybridization.
Topics: Anthracenes; Emodin; Fosfomycin; Glycine; Glyphosate; Hypericum; Indoleacetic Acids; Lovastatin; Perylene; Plant Shoots; Polyketide Synthases; Tissue Culture Techniques | 2014 |
Hypericum perforatum Reduces Paracetamol-Induced Hepatotoxicity and Lethality in Mice by Modulating Inflammation and Oxidative Stress.
Topics: Acetaminophen; Alanine Transaminase; Animals; Anthracenes; Anti-Inflammatory Agents; Antioxidants; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Glutathione; Hypericum; Inflammation; Male; Mice; Oxidative Stress; Perylene; Phloroglucinol; Plant Extracts; Plants, Medicinal; Quercetin; Rutin; Terpenes; Tumor Necrosis Factor-alpha | 2015 |
Spatial chemo-profiling of hypericin and related phytochemicals in Hypericum species using MALDI-HRMS imaging.
Topics: Anthracenes; Chromatography, High Pressure Liquid; Hypericum; Perylene; Phytochemicals; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2015 |
Permeation Characteristics of Hypericin across Caco-2 Monolayers in the Absence or Presence of Quercitrin - A Mass Balance Study.
Topics: Anthracenes; Biological Transport; Caco-2 Cells; Cell Membrane; Cell Survival; Humans; Hypericum; Molecular Structure; Molecular Weight; Perylene; Quercetin; Solubility | 2015 |
Effects of Hypericum perforatum extract and its main bioactive compounds on the cytotoxicity and expression of CYP1A2 and CYP2D6 in hepatic cells.
Topics: Anthracenes; Cell Line, Tumor; Cell Survival; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme Inhibitors; Drug Interactions; Enzyme Induction; Hepatocytes; Humans; Hypericum; Perylene; Phloroglucinol; Plant Extracts; RNA, Neoplasm; Terpenes; Tetrazolium Salts; Thiazoles | 2016 |
An innovative approach to prepare hypericin molecularly imprinted pearls using a "phyto-template".
Topics: Anthracenes; Chromatography, High Pressure Liquid; Hypericum; Molecular Imprinting; Perylene; Plant Extracts; Solid Phase Extraction; Spectroscopy, Fourier Transform Infrared | 2016 |
Interspecific variation in localization of hypericins and phloroglucinols in the genus Hypericum as revealed by desorption electrospray ionization mass spectrometry imaging.
Topics: Anthracenes; Hypericum; Perylene; Phloroglucinol; Plant Leaves; Species Specificity; Spectrometry, Mass, Electrospray Ionization; Terpenes | 2016 |
Apoptosis of THP-1 Macrophages Induced by Pseudohypericin-Mediated Sonodynamic Therapy Through the Mitochondria-Caspase Pathway.
Topics: Apoptosis; Caspases; Cell Line; Cell Survival; Cytochromes c; Humans; Hypericum; Macrophages; Membrane Potential, Mitochondrial; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Perylene; Plaque, Atherosclerotic; Reactive Oxygen Species; Ultrasonic Therapy | 2016 |
Shoot Tip Meristem Cryopreservation of Hypericum Species.
Topics: Acclimatization; Anthracenes; Chromatography, High Pressure Liquid; Chromosomes, Plant; Cryopreservation; Cryoprotective Agents; Cytogenetic Analysis; Flow Cytometry; Hypericum; Meristem; Perylene; Plant Shoots; Ploidies; Vitrification | 2016 |
Construction of Hypericin Gland-Specific cDNA Library via Suppression Subtractive Hybridization.
Topics: Anthracenes; Biosynthetic Pathways; DNA, Complementary; Gene Library; Germination; Hypericum; Perylene; Polymerase Chain Reaction; RNA, Messenger; RNA, Plant; Subtractive Hybridization Techniques | 2016 |
Arbuscular mycorrhizal fungi altered the hypericin, pseudohypericin, and hyperforin content in flowers of Hypericum perforatum grown under contrasting P availability in a highly organic substrate.
Topics: Anthracenes; Flowers; Hypericum; Mycorrhizae; Perylene; Phloroglucinol; Phosphorus; Plant Extracts; Terpenes | 2017 |
Permeation characteristics of hypericin across Caco-2 monolayers in the presence of single flavonoids, defined flavonoid mixtures or Hypericum extract matrix.
Topics: Anthracenes; Caco-2 Cells; Flavonoids; Humans; Hypericum; Intestinal Absorption; Permeability; Perylene; Plant Extracts | 2019 |
Optimized and Validated HPLC Analysis of St. John's Wort Extract and Final Products by Simultaneous Determination of Major Ingredients.
Topics: Anthracenes; Chlorogenic Acid; Chromatography, High Pressure Liquid; Drug Stability; Hypericum; Linear Models; Perylene; Plant Extracts; Quercetin; Reproducibility of Results; Rutin; Sensitivity and Specificity | 2017 |
Chemometric evaluation of hypericin and related phytochemicals in 17 in vitro cultured Hypericum species, hairy root cultures and hairy root-derived transgenic plants.
Topics: Anthracenes; Chromatography, Liquid; Hypericum; Mass Spectrometry; Perylene; Phytochemicals; Plant Extracts; Plant Leaves; Plant Roots; Plants, Genetically Modified; Principal Component Analysis; Secondary Metabolism | 2019 |
Strong antimicrobial activity of Hypericum perforatum L. against oral isolates of Lactobacillus spp.
Topics: Anthracenes; Anti-Infective Agents; Cell Line; Gingiva; Humans; Hypericum; Lactobacillus; Microbial Sensitivity Tests; Perylene; Plant Extracts | 2017 |
St. John's Wort Regulates Proliferation and Apoptosis in MCF-7 Human Breast Cancer Cells by Inhibiting AMPK/mTOR and Activating the Mitochondrial Pathway.
Topics: AMP-Activated Protein Kinases; Anthracenes; Breast Neoplasms; Cell Line, Tumor; Humans; Hypericum; MCF-7 Cells; Perylene; Signal Transduction; TOR Serine-Threonine Kinases | 2018 |
Optimized protocol for multigram preparation of emodin anthrone, a precursor in the hypericin synthesis.
Topics: Anthracenes; Anthraquinones; Emodin; Hypericum; Perylene; Radiation-Sensitizing Agents; Reducing Agents | 2019 |
Methodological aspects of biologically active compounds quantification in the genus Hypericum.
Topics: Anthracenes; Catechin; Chlorogenic Acid; Chromatography, High Pressure Liquid; Hypericum; Perylene; Phloroglucinol; Plant Extracts; Plant Leaves; Plant Stems; Quercetin; Rutin; Terpenes | 2018 |
Relation between hypericin content and morphometric leaf parameters in Hypericum spp.: A case of cubic degree polynomial function.
Topics: Anthracenes; Hypericum; Models, Biological; Perylene; Plant Leaves | 2018 |
Distinct Hypericum perforatum L. total extracts exert different antitumour activity on erythroleukemic K562 cells.
Topics: Anthracenes; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Flowers; Humans; Hypericum; K562 Cells; Perylene; Plant Extracts; Solvents | 2018 |
Phenotyping the genus Hypericum by secondary metabolite profiling: emodin vs. skyrin, two possible key intermediates in hypericin biosynthesis.
Topics: Anthracenes; Anthraquinones; Chromatography, Liquid; Emodin; Hypericum; Mass Spectrometry; Perylene; Phenotype; Plant Leaves; Secondary Metabolism | 2018 |
On the Mechanism of Action of Anti-Inflammatory Activity of Hypericin: An In Silico Study Pointing to the Relevance of Janus Kinases Inhibition.
Topics: Adenosine Triphosphate; Animals; Anthracenes; Anti-Inflammatory Agents; Binding, Competitive; Computer Simulation; Hypericum; Janus Kinase 1; Janus Kinase Inhibitors; Models, Molecular; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Perylene; Plant Extracts | 2018 |
Phytochemical Profiles and Antibacterial Activities of Hydroalcoholic Extracts of Origanum vulgare and Hypericum perforatum and Carvacrol and Hypericin as a Promising Anti-Staphylococcus aureus.
Topics: Anthracenes; Anti-Bacterial Agents; Candida albicans; Chromatography, High Pressure Liquid; Cymenes; Escherichia coli; Hypericum; Microbial Sensitivity Tests; Monoterpenes; Origanum; Perylene; Phytochemicals; Plant Extracts; Solid Phase Microextraction; Staphylococcus aureus | 2019 |
St John's wort extract influences membrane fluidity and composition of phosphatidylcholine and phosphatidylethanolamine in rat C6 glioblastoma cells.
Topics: Animals; Anthracenes; Cell Line, Tumor; Cell Membrane; Glioblastoma; Hydrocortisone; Hypericum; Membrane Fluidity; Perylene; Phloroglucinol; Phosphatidylethanolamines; Plant Extracts; Quercetin; Rats; Receptors, Adrenergic, beta-1; Signal Transduction; Terpenes | 2019 |
Temperature-dependent growth and hypericin biosynthesis in Hypericum perforatum.
Topics: Anthracenes; Hypericum; Perylene; Plant Leaves; Plant Proteins; Temperature | 2019 |
Discovery of key regulators of dark gland development and hypericin biosynthesis in St. John's Wort (Hypericum perforatum).
Topics: Anthracenes; Flavonoids; Genes, Plant; Hypericum; Metabolome; Perylene; Transcriptome | 2019 |
Natural constituents of St. John's Wort inhibit the proteolytic activity of human thrombin.
Topics: Anthracenes; Dose-Response Relationship, Drug; Fibrinolytic Agents; Hypericum; Kinetics; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Perylene; Plant Extracts; Proteolysis; Structure-Activity Relationship | 2019 |
Host metabolite producing endophytic fungi isolated from Hypericum perforatum.
Topics: Anthracenes; Anti-Infective Agents; Chloroform; Chromatography, High Pressure Liquid; Emodin; Fermentation; Fungi, Unclassified; Hypericum; Industrial Microbiology; Methanol; Microbial Sensitivity Tests; Perylene; Phylogeny; Plant Extracts; Plants, Medicinal; Secondary Metabolism; Staphylococcus aureus; Streptomyces; Tandem Mass Spectrometry | 2019 |
Ultrasound-assisted packed-bed extraction of hypericin from Hypericum perforatum L. and optimization by response surface methodology.
Topics: Anthracenes; Chromatography, High Pressure Liquid; Ethanol; Hypericum; Methanol; Models, Chemical; Perylene; Reproducibility of Results; Solvents; Temperature; Time Factors; Ultrasonic Waves | 2019 |
An Electron paramagnetic resonance (EPR) spin labeling study in HT-29 Colon adenocarcinoma cells after Hypericin-mediated photodynamic therapy.
Topics: Adenocarcinoma; Anthracenes; Cell Membrane; Colonic Neoplasms; Computer Simulation; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; HT29 Cells; Humans; Hydrophobic and Hydrophilic Interactions; Hypericum; Membrane Fluidity; Neoplasm Recurrence, Local; Perylene; Photochemotherapy; Photosensitizing Agents; Plant Extracts; Spin Labels | 2019 |
Effect of different quality of light on growth and production of secondary metabolites in adventitious root cultivation of Hypericum perforatum.
Topics: Anthracenes; Biomass; Culture Media; Flavonoids; Hypericum; Light; Perylene; Phenols; Plant Roots; Secondary Metabolism; Sugars | 2019 |
Variability of Hypericins and Hyperforin in Hypericum Species from the Sicilian Flora.
Topics: Anthracenes; Hypericum; Perylene; Phloroglucinol; Sicily; Species Specificity; Terpenes | 2020 |
MALDI-HRMS Imaging Maps the Localization of Skyrin, the Precursor of Hypericin, and Pathway Intermediates in Leaves of
Topics: Anthracenes; Anthraquinones; Hypericum; Metabolic Networks and Pathways; Molecular Structure; Perylene; Phytochemicals; Plant Leaves; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2020 |
Hypericin, a medicinal compound from St. John's Wort, inhibits genotoxicity induced by mutagenic agents in V79 cells.
Topics: Anthracenes; DNA Damage; Hypericum; Mutagens; Perylene; Plant Extracts | 2022 |
Physiological and Transcriptomic Analysis Provide Insight into Low Temperature Enhancing Hypericin Biosynthesis in
Topics: Anthracenes; Gene Expression Profiling; Hypericum; Perylene; Temperature; Transcriptome | 2021 |
Anti-fatigue effect of hypericin in a chronic forced exercise mouse model.
Topics: Acetylcholine; Animals; Anthracenes; Cell Line; Cell Survival; Fatigue; Gene Expression Regulation; Hydrogen Peroxide; Hypericum; Male; Mice; Mice, Inbred ICR; Myoblasts; Oxidative Stress; Perylene; Physical Conditioning, Animal; Phytotherapy; Random Allocation; Swimming | 2022 |
Development of new and validated HPTLC methods for the qualitative and quantitative analysis of hyperforin, hypericin and hyperoside contents in Hypericum species.
Topics: Anthracenes; Chromatography, Thin Layer; Hypericum; Perylene; Phloroglucinol; Plant Extracts; Quercetin; Terpenes | 2022 |
Regeneration of Phytochemicals by Structure-Driven Organization of Microbial Biosynthetic Steps.
Topics: Anthracenes; Fungi; Hypericum; Molecular Structure; Perylene; Phytochemicals | 2022 |
Substrate-dependent Inhibition of Hypericin on Human Carboxylesterase 2: Implications for Herb-drug Combination.
Topics: Anthracenes; Drug Combinations; Herb-Drug Interactions; Humans; Hypericum; Irinotecan; Molecular Docking Simulation; Perylene | 2022 |
Biosynthesis of titanium dioxide nanoparticles using Hypericum perforatum and Origanum vulgare extracts and their main components, hypericin and carvacrol as promising antibacterial agents.
Topics: Anthracenes; Anti-Bacterial Agents; Antineoplastic Agents; Bacteria; Cymenes; Humans; Hypericum; Nanoparticles; Origanum; Perylene; Plant Extracts; Plant Oils; Staphylococcus aureus; Titanium | 2022 |