perylene has been researched along with hyperforin in 95 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 11 (11.58) | 18.2507 |
| 2000's | 58 (61.05) | 29.6817 |
| 2010's | 23 (24.21) | 24.3611 |
| 2020's | 3 (3.16) | 2.80 |
| Authors | Studies |
|---|---|
| Chatterjee, SS; Erdelmeier, C; Koch, E; Nöldner, M | 1 |
| Hafner, U; Müller, WE; Rolli, M; Schäfer, C; Singer, A; Wonnemann, M | 1 |
| Bhattacharya, SK; Chakrabarti, A; Chatterjee, SS | 1 |
| Dimpfel, W; Mannel, M; Schober, F | 1 |
| Biber, A; Chatterjee, SS; Fischer, H; Römer, A | 1 |
| Dimpfel, W; Sauer, S; Schellenberg, R | 1 |
| Baghai, T; Kieser, M; Laakmann, G; Schüle, C | 1 |
| Bhattacharya, SK; Chatterjee, SS; Müller, WE; Singer, A; Wonnemann, M | 1 |
| Campling, G; Chi, J; Cowen, PJ; Franklin, M; Hockney, R; McGavin, C; Reed, A; Whale, RW | 1 |
| Fiebich, BL; Heinrich, M; Kammerer, N; Langosch, JM; Lieb, K | 1 |
| Obach, RS | 1 |
| Agostini, M; Chatterjee, VK; Love, J; Schwabe, JW; Wentworth, JM | 1 |
| Agrosi, M; Harrasser, PC; Mischiatti, S; Savio, D | 1 |
| Hunt, EJ; Lester, CE; Lester, EA; Tackett, RL | 1 |
| Chatterjee, S; Nöldner, M | 1 |
| Müller, WE; Siebert, B; Singer, A; Wonnemann, M | 1 |
| Baumeister, A; Dressman, J; Kaunzinger, A; Schubert-Zsilovecz, M; Westerhoff, K; Wilke, A; Wurglics, M | 1 |
| Cowen, PJ; Franklin, M | 1 |
| Gobbi, M; Mennini, T; Moia, M; Morizzoni, P; Pirona, L | 1 |
| Calapai, G; Caputi, AP; Ciliberto, G; Crupi, A; De Sarro, G; Firenzuoli, F; Inferrera, G; Parisi, A | 1 |
| de los Reyes, GC; Koda, RT | 2 |
| Coutts, RT; Gu, LD; Ling, L; Pang, PK; Shan, JJ; Sloley, BD; Urichuk, LJ | 1 |
| Hansen, SH; Jensen, AG | 1 |
| Bauer, S; Graubaum, HJ; Roots, I; Störmer, E | 1 |
| Bray, BJ; Brennan, NJ; Menkes, DB; Perry, NB; Rosengren, RJ | 1 |
| Bonn, GK; Huck, CW; Pirker, R | 1 |
| Murch, SJ; Rupasinghe, HP; Saxena, PK | 1 |
| Berger Büter, K; Bobirnac, I; Lübbert, H; Schaffner, W; Schoeffter, P; Simmen, U; Ullmer, C | 1 |
| Schmitt, J | 1 |
| Butterweck, V; Christoffel, V; Nahrstedt, A; Petereit, F; Spengler, B; Winterhoff, H | 1 |
| Schmidt, PC | 1 |
| Bommer, S; Hostanska, K; Reichling, J; Saller, R; Weber, M | 1 |
| Gibson, DM; Kaufman, PB; Kirakosyan, A; Sirvent, TM | 1 |
| Butterweck, V; Simbrey, K; Winterhoff, H | 1 |
| Gibson, DM; Krasnoff, SB; Sirvent, TM | 1 |
| Barecki-Roach, M; Johnson, WW; Wang, EJ | 1 |
| Gobbi, M; Mennini, T | 1 |
| Borrelli, F; Capasso, F; Capasso, R; Izzo, AA; Mascolo, N | 1 |
| Burhenne, J; Haefeli, WE; Martin-Facklam, M; Riedel, KD; Rieger, K; Walter-Sack, I | 1 |
| Burhenne, J; Haefeli, WE; Martin-Facklam, M; Mikus, G; Riedel, KD; Rieger, K | 1 |
| Koyabu, N; Morimoto, S; Ohtani, H; Sawada, Y; Shoyama, Y; Tian, R | 1 |
| Bässler, D; Schulz, HU; Schürer, M; Weiser, D | 2 |
| Altieri, V; Borrelli, F; Capasso, F; Capasso, R; Izzo, AA; Montanaro, V | 1 |
| Fiamegos, YC; Gioti, EM; Skalkos, DC; Stalikas, CD | 1 |
| Lawvere, S; Mahoney, MC | 1 |
| Ashton, D; Chandrasekera, DH; Heinrich, M; Middleton, R; Welham, KJ | 1 |
| Furumoto, M; Haito, S; Ito, M; Kawai, Y; Miyamoto, K; Terao, J | 1 |
| Smelcerovic, A; Spiteller, M; Zuehlke, S | 1 |
| Schubert-Zsilavecz, M; Wurglics, M | 1 |
| Cao, J; Chan, E; Chen, X; Duan, W; Hu, ZP; Huang, M; Wen, JY; Yang, XX; Yu, XQ; Zhou, SF | 1 |
| Exner, M; Gmeiner, BM; Hermann, M; Kapiotis, S; Laggner, H; Mühl, A; Schreier, S | 1 |
| Bornancin, A; Della Loggia, R; Morazzoni, P; Pace, R; Riva, A; Sosa, S; Tubaro, A | 1 |
| Gödtel-Armbrust, U; Kelber, O; Kroll, U; Metzger, A; Wojnowski, L | 1 |
| Klejdus, B; Kuban, V; Pavlík, M; Vacek, J | 1 |
| Klejdus, B; Kubán, V; Vacek, J | 1 |
| Birt, DF; Delate, K; Dixon, PM; Hammer, KD; Hillwig, ML; Murphy, PA; Solco, AK; Wurtele, ES | 1 |
| Butterweck, V; Schmidt, M | 1 |
| Beffy, P; D'Aleo, V; Lupi, R; Marchetti, P; Masiello, P; Menegazzi, M; Novelli, M; Suzuki, H; Tedeschi, E; Zoratti, E | 1 |
| Canegallo, L; Carrassi, A; Demarosi, F; Lodi, G; Sardella, A; Tarozzi, M | 1 |
| Bertoli, A; Giovannini, A; Guardo, AD; Mazzetti, M; Pistelli, L; Ruffoni, B; Spinelli, G | 1 |
| Cirak, C; Ivanauskas, L; Janulis, V; Radusiene, J | 3 |
| Khalifa, AE; Mohamed, MR; Sabry, GM; Sabry, NA; Tadros, MG; Youssef, AM | 1 |
| Chen, J; Chen, X; Du, J; Guan, S; He, YW; Huang, M; Li, JL; Su, QB; Wang, XD; Zeng, J; Zhang, JX; Zhou, SF | 1 |
| Kavanagh, DJ; Sarris, J | 1 |
| Borsarini, A; Caniato, R; Filippini, R; Piovan, A | 1 |
| Caccia, S; Gobbi, M | 1 |
| Butterweck, V; Nahrstedt, A | 1 |
| Gilani, AH; Khan, AU | 1 |
| Bai, G; Cao, X; Ito, Y; Li, Y; Ren, H; Wang, Q; Xu, C | 1 |
| Hatano, T; Inoue, R; Ito, H; Ochi, M; Onoue, S; Seto, Y; Yamada, S | 1 |
| Miller, CD; Mortensen, T; Shen, F; Shen, S; Sims, RC; Walsh, MK | 1 |
| Caliskan, O; Camas, N; Cirak, C; Radusiene, J; Stanius, Z | 1 |
| Fedoročko, P; Jendželovský, R; Mikeš, J; Šemeláková, M | 1 |
| Capasso, R; Pessina, F; Valeri, A; Valoti, M | 1 |
| Bouron, A; Lorrain, E | 1 |
| Chimirri, S; Ciriaco, M; De Sarro, G; Esposito, S; Mammì, M; Mazzitello, C; Palleria, C; Patanè, M; Pugliese, M; Russo, E; Scicchitano, F; Upton, R; Whalley, BJ | 1 |
| Burico, M; Galeotti, N; Ghelardini, C; Maidecchi, A; Mattoli, L | 1 |
| Birt, DF; Hammer, KD | 1 |
| Arakawa, NS; Cardoso, RD; Casagrande, R; Fattori, V; Hohmann, MS; Lopes, NP; Tomaz, JC; Verri, WA | 1 |
| Alves, G; Domingues, F; Duarte, AP; Gallardo, E; Granadeiro, LB; Martinho, A; Moreno, I; Silva, SM; Silvestre, S | 1 |
| Fedoročko, P; Jendželovský, R; Šemeláková, M | 1 |
| Carrubba, A; Lazzara, S; Militello, M; Napoli, E; Saia, S | 1 |
| Ho, CY; Ng, QX; Venkatanarayanan, N | 1 |
| Dresler, S; Kováčik, J; Sowa, I; Strzemski, M; Wójciak-Kosior, M | 1 |
| Fedoročko, P; Sačková, V; Šemeláková, M | 1 |
| Boonen, G; Bussmann, H; Drewe, J; Franken, S; Häberlein, H; Keksel, N; Unger, M | 1 |
| Babinčák, M; Buríková, M; Fedoročko, P; Jendželovská, Z; Jendželovský, R; Košuth, J; Majerník, M; Ševc, J; Tonelli Gombalová, Z | 1 |
| Carrubba, A; Lazzara, S; Napoli, E | 1 |
| Altschmied, L; D'Auria, JC; Ravindran, BM; Rizzo, P; Rutten, T | 1 |
| Saçıcı, E; Yesilada, E | 1 |
15 review(s) available for perylene and hyperforin
| Article | Year |
|---|---|
[Formulation of St. John's wort extract. A medicinal obstacle course].
Topics: Anthracenes; Bridged Bicyclo Compounds; Chemistry, Pharmaceutical; Drug Compounding; Humans; Hypericum; Perylene; Phloroglucinol; Plant Extracts; Solvents; Terpenes | 2003 |
The production of hypericins and hyperforin by in vitro cultures of St. John's wort (Hypericum perforatum).
Topics: Anthracenes; Anti-Bacterial Agents; Antineoplastic Agents; Bridged Bicyclo Compounds; Culture Techniques; Hypericum; Perylene; Phloroglucinol; Plants, Medicinal; Terpenes | 2004 |
The antidepressant mechanism of Hypericum perforatum.
Topics: Animals; Anthracenes; Bridged Bicyclo Compounds; Depression; Disease Models, Animal; Hypericum; Neurotransmitter Agents; Perylene; Phloroglucinol; Phytotherapy; Plant Extracts; Rats; Receptors, Dopamine D1; Receptors, Opioid; Terpenes | 2004 |
St. John's wort.
Topics: Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Depression; Humans; Hypericum; Perylene; Phloroglucinol; Phytotherapy; Plant Preparations; Terpenes; Treatment Outcome | 2005 |
Hypericum perforatum: a 'modern' herbal antidepressant: pharmacokinetics of active ingredients.
Topics: Animals; Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Clinical Trials as Topic; Depression; Flavonoids; Humans; Hypericum; Perylene; Phloroglucinol; Phytotherapy; Plant Extracts; Terpenes | 2006 |
[Hypericin and hyperforin: bioactive components of St. John's Wort (Hypericum perforatum). Their isolation, analysis and study of physiological effect].
Topics: Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Depressive Disorder; Humans; Hypericum; Perylene; Phloroglucinol; Phytotherapy; Plant Extracts; Plants, Medicinal; Terpenes | 2007 |
St. John's wort: role of active compounds for its mechanism of action and efficacy.
Topics: Animals; Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Cells, Cultured; Clinical Trials as Topic; Disease Models, Animal; Humans; Hypericum; Ice; Meta-Analysis as Topic; Perylene; Phloroglucinol; Phytotherapy; Plant Extracts; Terpenes | 2007 |
Kava and St. John's Wort: current evidence for use in mood and anxiety disorders.
Topics: Anthracenes; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Bridged Bicyclo Compounds; Humans; Hypericum; Kava; Mood Disorders; Perylene; Phloroglucinol; Phytotherapy; Plant Extracts; Terpenes | 2009 |
St. John's wort components and the brain: uptake, concentrations reached and the mechanisms underlying pharmacological effects.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Blood-Brain Barrier; Brain; Bridged Bicyclo Compounds; Flavonols; Humans; Hypericum; Nootropic Agents; Permeability; Perylene; Phloroglucinol; Plant Preparations; Psychotropic Drugs; Terpenes | 2009 |
Lessons learned from herbal medicinal products: the example of St. John's Wort (perpendicular).
Topics: Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Hypericum; Molecular Structure; Perylene; Phloroglucinol; Plant Preparations; Plants, Medicinal; Terpenes | 2010 |
[Cellular and molecular effects of the antidepressant hyperforin on brain cells: Review of the literature].
Topics: Anthracenes; Antidepressive Agents; Brain; Hypericum; Neurons; Perylene; Phloroglucinol; Terpenes | 2014 |
Hypericum perforatum: pharmacokinetic, mechanism of action, tolerability, and clinical drug-drug interactions.
Topics: Anthracenes; Antidepressive Agents; Antiviral Agents; Depression; Herb-Drug Interactions; Humans; Hypericum; Perylene; Phloroglucinol; Plant Extracts; Plants, Medicinal; Terpenes | 2014 |
Evidence for contributions of interactions of constituents to the anti-inflammatory activity of Hypericum perforatum.
Topics: Animals; Anti-Inflammatory Agents; Biflavonoids; Disease Models, Animal; Flavonoids; Humans; Hypericum; Perylene; Phloroglucinol; Plant Extracts; Signal Transduction; Terpenes | 2014 |
Clinical use of Hypericum perforatum (St John's wort) in depression: A meta-analysis.
Topics: Anthracenes; Antidepressive Agents; Depression; Humans; Hypericum; Perylene; Phloroglucinol; Phytotherapy; Plant Extracts; Selective Serotonin Reuptake Inhibitors; Terpenes | 2017 |
The Biochemical and Genetic Basis for the Biosynthesis of Bioactive Compounds in
Topics: Anthracenes; Antidepressive Agents; Antineoplastic Agents; Europe; Humans; Hypericum; Perylene; Phloroglucinol; Phytochemicals; Plant Extracts; Plant Proteins; Terpenes | 2020 |
9 trial(s) available for perylene and hyperforin
| Article | Year |
|---|---|
Oral bioavailability of hyperforin from hypericum extracts in rats and human volunteers.
Topics: Administration, Oral; Adult; Animals; Area Under Curve; Biological Availability; Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Female; Half-Life; Humans; Hypericum; Male; Perylene; Phloroglucinol; Plant Extracts; Plants, Medicinal; Quercetin; Rats; Rats, Sprague-Dawley; Terpenes; Xanthenes | 1998 |
Pharmacodynamic effects of two different hypericum extracts in healthy volunteers measured by quantitative EEG.
Topics: Adult; Anthracenes; Bridged Bicyclo Compounds; Cerebral Cortex; Electroencephalography; Female; Humans; Hypericum; Male; Perylene; Phloroglucinol; Plant Extracts; Plants, Medicinal; Quercetin; Terpenes; Xanthenes | 1998 |
St. John's wort in mild to moderate depression: the relevance of hyperforin for the clinical efficacy.
Topics: Antidepressive Agents; Bridged Bicyclo Compounds; Depressive Disorder; Double-Blind Method; Female; Humans; Hypericum; Male; Middle Aged; Perylene; Phloroglucinol; Plant Extracts; Plants, Medicinal; Quercetin; Terpenes; Xanthenes | 1998 |
Neuroendocrine evidence for dopaminergic actions of hypericum extract (LI 160) in healthy volunteers.
Topics: Adult; Anthracenes; Anti-Bacterial Agents; Antidepressive Agents; Bridged Bicyclo Compounds; Cross-Over Studies; Double-Blind Method; Ericales; Humans; Hydrocortisone; Male; Middle Aged; Perylene; Phloroglucinol; Plants, Medicinal; Prolactin; Somatostatin; Terpenes | 1999 |
Oral bioavailability of active principles from herbal products in humans. A study on Hypericum perforatum extracts using the soft gelatin capsule technology.
Topics: Administration, Oral; Adult; Anthracenes; Antidepressive Agents; Area Under Curve; Biological Availability; Bridged Bicyclo Compounds; Capsules; Chromatography, High Pressure Liquid; Cross-Over Studies; Female; Gelatin; Humans; Hypericum; Male; Mass Spectrometry; Perylene; Phloroglucinol; Plant Extracts; Plants, Medicinal; Reference Values; Terpenes | 2000 |
Researching the antidepressant actions of Hypericum perforatum (St. John's wort) in animals and man.
Topics: Adult; Animals; Anthracenes; Antidepressive Agents; Brain Chemistry; Bridged Bicyclo Compounds; Corticosterone; Cross-Over Studies; Double-Blind Method; Humans; Hypericum; Ketanserin; Male; Middle Aged; Neurosecretory Systems; Perylene; Phloroglucinol; Piperazines; Plant Extracts; Prolactin; Pyridines; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Antagonists; Terpenes | 2001 |
Investigation of the bioavailability of hypericin, pseudohypericin, hyperforin and the flavonoids quercetin and isorhamnetin following single and multiple oral dosing of a hypericum extract containing tablet.
Topics: Adolescent; Adult; Anthracenes; Antidepressive Agents; Area Under Curve; Biological Availability; Bridged Bicyclo Compounds; Flavonols; Humans; Hypericum; Male; Middle Aged; Perylene; Phloroglucinol; Plant Extracts; Quercetin; Tablets; Terpenes | 2005 |
Investigation of pharmacokinetic data of hypericin, pseudohypericin, hyperforin and the flavonoids quercetin and isorhamnetin revealed from single and multiple oral dose studies with a hypericum extract containing tablet in healthy male volunteers.
Topics: Adolescent; Adult; Anthracenes; Bridged Bicyclo Compounds; Flavonols; Humans; Hypericum; Male; Middle Aged; Perylene; Phloroglucinol; Plant Extracts; Quercetin; Tablets; Terpenes | 2005 |
Hypericum perforatum extract in burning mouth syndrome: a randomized placebo-controlled study.
Topics: Aged; Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Burning Mouth Syndrome; Double-Blind Method; Female; Humans; Hypericum; Male; Middle Aged; Perylene; Phloroglucinol; Phytotherapy; Plant Extracts; Statistics, Nonparametric; Terpenes; Treatment Outcome | 2008 |
71 other study(ies) available for perylene and hyperforin
| Article | Year |
|---|---|
[Therapy of mild to medium degree depression].
Topics: Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Depression; Depressive Disorder; Humans; Monoamine Oxidase Inhibitors; Perylene; Phloroglucinol; Plant Extracts; Plant Oils; Severity of Illness Index; Terpenes | 1998 |
Antidepressant activity of hypericum perforatum and hyperforin: the neglected possibility.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Bridged Bicyclo Compounds; Cells, Cultured; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Guinea Pigs; Heart Rate; Hypericum; Ileum; In Vitro Techniques; Male; Muscle Contraction; Perylene; Phloroglucinol; Plant Extracts; Plants, Medicinal; Quercetin; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Terpenes; Xanthenes | 1998 |
Hyperforin represents the neurotransmitter reuptake inhibiting constituent of hypericum extract.
Topics: Animals; Brain; Bridged Bicyclo Compounds; Dopamine; Female; Hypericum; Male; Mice; Monoamine Oxidase; Neurotransmitter Uptake Inhibitors; Norepinephrine; Perylene; Phloroglucinol; Plant Extracts; Plants, Medicinal; Quercetin; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Receptors, Serotonin; Serotonin; Synaptosomes; Terpenes; Xanthenes | 1998 |
Activity profiles of two hyperforin-containing hypericum extracts in behavioral models.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Body Temperature; Bridged Bicyclo Compounds; Hypericum; Male; Mice; Perylene; Phloroglucinol; Plant Extracts; Plants, Medicinal; Quercetin; Rats; Stereotyped Behavior; Terpenes; Xanthenes | 1998 |
Effects of a methanolic extract and a hyperforin-enriched CO2 extract of St. John's Wort (Hypericum perforatum) on intracerebral field potentials in the freely moving rat (Tele-Stereo-EEG).
Topics: Animals; Brain; Bridged Bicyclo Compounds; Carbon Dioxide; Electrodes, Implanted; Electroencephalography; Hypericum; Male; Methanol; Perylene; Phloroglucinol; Plant Extracts; Plants, Medicinal; Quercetin; Rats; Terpenes; Xanthenes | 1998 |
Hyperforin as a possible antidepressant component of hypericum extracts.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Bridged Bicyclo Compounds; Helplessness, Learned; Hypericum; Male; Models, Chemical; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neurotransmitter Uptake Inhibitors; Perylene; Phloroglucinol; Plant Extracts; Plants, Medicinal; Quercetin; Rats; Synaptosomes; Terpenes; Xanthenes | 1998 |
Antibacterial activity of hyperforin from St John's wort.
Topics: Anthracenes; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Bridged Bicyclo Compounds; Cell Line; Dose-Response Relationship, Drug; Ericales; Humans; Perylene; Phloroglucinol; Terpenes | 1999 |
Inhibition of human cytochrome P450 enzymes by constituents of St. John's Wort, an herbal preparation used in the treatment of depression.
Topics: Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Chlorogenic Acid; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors; Humans; Hypericum; Perylene; Phloroglucinol; Plant Extracts; Plants, Medicinal; Quercetin; Terpenes | 2000 |
St John's wort, a herbal antidepressant, activates the steroid X receptor.
Topics: Animals; Anthracenes; Antidepressive Agents; Aryl Hydrocarbon Hydroxylases; Binding, Competitive; Bridged Bicyclo Compounds; Corticosterone; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Histone Acetyltransferases; Humans; Hypericum; Mice; Nuclear Receptor Coactivator 1; Oxidoreductases, N-Demethylating; Perylene; Phloroglucinol; Plants, Medicinal; Pregnane X Receptor; Protein Binding; Receptors, Steroid; Rifampin; Terpenes; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured | 2000 |
Effect of St. John's wort on free radical production.
Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Anthracenes; Antioxidants; Bridged Bicyclo Compounds; Cell-Free System; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Free Radicals; Humans; Hypericum; Indicators and Reagents; Perylene; Phloroglucinol; Placenta; Plant Extracts; Plants, Medicinal; Pregnancy; Superoxides; Terpenes; Veins | 2001 |
Effects of two different extracts of St. John's wort and some of their constituents on cytochrome P450 activities in rat liver microsomes.
Topics: Animals; Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Cytochrome P-450 Enzyme System; Ethanol; Excitatory Amino Acid Antagonists; Female; Hypericum; Liver; Male; Methanol; Microsomes; Perylene; Phenobarbital; Phloroglucinol; Plant Extracts; Quercetin; Rats; Rats, Sprague-Dawley; Sex Factors; Solvents; Terpenes | 2001 |
Evaluation of synaptosomal uptake inhibition of most relevant constituents of St. John's wort.
Topics: Animals; Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Dopamine; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glutamic Acid; Hypericum; Male; Neurotransmitter Agents; Norepinephrine; Perylene; Phloroglucinol; Plant Extracts; Rats; Rats, Wistar; Serotonin; Synaptosomes; Terpenes | 2001 |
Batch-to-batch reproducibility of St. John's wort preparations.
Topics: Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Chemistry, Pharmaceutical; Humans; Hypericum; Perylene; Phloroglucinol; Phytotherapy; Plant Extracts; Reproducibility of Results; Terpenes | 2001 |
In vitro binding studies with two hypericum perforatum extracts--hyperforin, hypericin and biapigenin--on 5-HT6, 5-HT7, GABA(A)/benzodiazepine, sigma, NPY-Y1/Y2 receptors and dopamine transporters.
Topics: Animals; Anthracenes; Antidepressive Agents; Apigenin; Biflavonoids; Bridged Bicyclo Compounds; Dopamine Plasma Membrane Transport Proteins; Flavonoids; Hypericum; In Vitro Techniques; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Perylene; Phloroglucinol; Plant Extracts; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Neuropeptide Y; Receptors, Serotonin; Receptors, sigma; Terpenes | 2001 |
Interleukin-6 involvement in antidepressant action of Hypericum perforatum.
Topics: Administration, Oral; Animals; Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Diencephalon; Dose-Response Relationship, Drug; Hydroxyindoleacetic Acid; Hypericum; Immune System; Interleukin-6; Male; Mice; Mice, Knockout; Perylene; Phloroglucinol; Plant Extracts; Rutin; Serotonin; Swimming; Terpenes; Tryptophan | 2001 |
Development of a simple, rapid and reproducible HPLC assay for the simultaneous determination of hypericins and stabilized hyperforin in commercial St. John's wort preparations.
Topics: Anthracenes; Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Hypericum; Perylene; Phloroglucinol; Reproducibility of Results; Solutions; Terpenes | 2001 |
Chemical and pharmacological evaluation of Hypericum perforatum extracts.
Topics: Animals; Anthracenes; Antioxidants; Bridged Bicyclo Compounds; Free Radical Scavengers; Hippocampus; Hypericum; Male; Perylene; Phloroglucinol; Quercetin; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Terpenes | 2000 |
Separation of hypericins and hyperforins in extracts of Hypericum perforatum L. using non-aqueous capillary electrophoresis with reversed electro-osmotic flow.
Topics: Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Electrolytes; Electrophoresis, Capillary; Hypericum; Molecular Structure; Osmotic Pressure; Perylene; Phloroglucinol; Plant Extracts; Reproducibility of Results; Rheology; Solvents; Terpenes | 2002 |
Determination of hyperforin, hypericin, and pseudohypericin in human plasma using high-performance liquid chromatography analysis with fluorescence and ultraviolet detection.
Topics: Anthracenes; Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Humans; Perylene; Phloroglucinol; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Terpenes | 2001 |
Short term treatment with St. John's wort, hypericin or hyperforin fails to induce CYP450 isoforms in the Swiss Webster mouse.
Topics: Alanine Transaminase; Animals; Anthracenes; Antidepressive Agents; Body Weight; Bridged Bicyclo Compounds; Cytochrome P-450 Enzyme System; Enzyme Induction; Hypericum; Isoenzymes; Liver; Male; Mice; Perylene; Phloroglucinol; Plant Preparations; Terpenes | 2002 |
Determining hyperforin and hypericin content in eight brands of St. John's wort.
Topics: Anthracenes; Anti-Bacterial Agents; Antidepressive Agents; Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Dosage Forms; Humans; Hypericum; Perylene; Phloroglucinol; Phytotherapy; Plant Extracts; Plants, Medicinal; Terpenes | 2002 |
Simultaneous determination of hypericin and hyperforin in human plasma and serum using liquid-liquid extraction, high-performance liquid chromatography and liquid chromatography-tandem mass spectrometry.
Topics: Anthracenes; Bridged Bicyclo Compounds; Calibration; Chromatography, Liquid; Hypericum; Mass Spectrometry; Perylene; Phloroglucinol; Reproducibility of Results; Terpenes | 2002 |
An in vitro and hydroponic growing system for hypericin, pseudohypericin, and hyperforin production of St. John's wort (Hypericum perforatum CV new stem).
Topics: Anthracenes; Bridged Bicyclo Compounds; Culture Techniques; Environment, Controlled; Hydroponics; Hypericum; Perylene; Phloroglucinol; Plant Extracts; Terpenes | 2002 |
Antagonist effect of pseudohypericin at CRF1 receptors.
Topics: Animals; Anthracenes; Bridged Bicyclo Compounds; Calcitonin; CHO Cells; Corticotropin-Releasing Hormone; Cricetinae; Cyclic AMP; Dose-Response Relationship, Drug; Humans; Perylene; Phloroglucinol; Receptors, Corticotropin-Releasing Hormone; Terpenes; Transfection | 2003 |
[Dangerous interaction of St. John's wort with chemotherapy?].
Topics: Anthracenes; Antineoplastic Agents; Bridged Bicyclo Compounds; Drug Interactions; Humans; Hypericum; Perylene; Phloroglucinol; Terpenes | 2003 |
Step by step removal of hyperforin and hypericin: activity profile of different Hypericum preparations in behavioral models.
Topics: Administration, Oral; Animals; Anthracenes; Antidepressive Agents; Behavior, Animal; Bridged Bicyclo Compounds; Female; Hypericum; Male; Mice; Mice, Inbred Strains; Motor Activity; Perylene; Phloroglucinol; Physical Exertion; Plant Extracts; Rats; Rats, Inbred Strains; Swimming; Terpenes | 2003 |
Hyperforin a constituent of St John's wort (Hypericum perforatum L.) extract induces apoptosis by triggering activation of caspases and with hypericin synergistically exerts cytotoxicity towards human malignant cell lines.
Topics: Annexin A5; Anthracenes; Antineoplastic Agents; Antioxidants; Apoptosis; Astrocytes; Biflavonoids; Bridged Bicyclo Compounds; Caspases; Catechin; Cell Division; Cell Line, Tumor; Cells, Cultured; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Humans; Hypericum; Perylene; Phloroglucinol; Plant Extracts; Proanthocyanidins; Terpenes | 2003 |
Extracts of St. John's wort and various constituents affect beta-adrenergic binding in rat frontal cortex.
Topics: Animals; Anthracenes; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Bridged Bicyclo Compounds; Cell Membrane; Fluoxetine; Frontal Lobe; Hypericum; Imipramine; Male; Perylene; Phloroglucinol; Plant Extracts; Quercetin; Radioligand Assay; Rats; Receptors, Adrenergic, beta; Terpenes | 2004 |
Induction of hypericins and hyperforins in Hypericum perforatum in response to damage by herbivores.
Topics: Adaptation, Physiological; Animals; Anthracenes; Anti-Bacterial Agents; Biological Assay; Bridged Bicyclo Compounds; Coleoptera; Enzyme Inhibitors; Feeding Behavior; Hypericum; Larva; Moths; Perylene; Phloroglucinol; Plants, Edible; Terpenes | 2003 |
Quantitative characterization of direct P-glycoprotein inhibition by St John's wort constituents hypericin and hyperforin.
Topics: Animals; Anthracenes; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bridged Bicyclo Compounds; Flow Cytometry; Genes, MDR; Herb-Drug Interactions; Humans; Hypericum; Mice; NIH 3T3 Cells; Perylene; Phloroglucinol; Terpenes | 2004 |
Inhibitory effect of the antidepressant St. John's wort (hypericum perforatum) on rat bladder contractility in vitro.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Anthracenes; Antidepressive Agents; Atropine; Bridged Bicyclo Compounds; Capsaicin; Depression; Electric Stimulation; Female; Haloperidol; Hypericum; Kaempferols; Male; Methysergide; Muscle Contraction; Muscle, Smooth; Naloxone; Perylene; Phentolamine; Phloroglucinol; Piperidines; Plant Extracts; Propranolol; Pyrazoles; Quercetin; Rats; Rats, Wistar; Rimonabant; Rutin; Terpenes; Tetrodotoxin; Urinary Bladder; Urinary Incontinence; Verapamil | 2004 |
Undeclared exposure to St. John's Wort in hospitalized patients.
Topics: Adult; Aged; Aged, 80 and over; Anthracenes; Bridged Bicyclo Compounds; Drug Interactions; Hospitalization; Humans; Hypericum; Middle Aged; Perylene; Phloroglucinol; Self Medication; Substance Abuse Detection; Terpenes | 2004 |
Simultaneous determination of hypericin and hyperforin in human plasma with liquid chromatography-tandem mass spectrometry.
Topics: Aged; Anthracenes; Bridged Bicyclo Compounds; Calibration; Chromatography, High Pressure Liquid; Female; Humans; Perylene; Phloroglucinol; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Terpenes | 2004 |
Functional induction and de-induction of P-glycoprotein by St. John's wort and its ingredients in a human colon adenocarcinoma cell line.
Topics: Adenocarcinoma; Animals; Anthracenes; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Bridged Bicyclo Compounds; Cell Line, Tumor; Colonic Neoplasms; Digoxin; Humans; Hypericum; LLC-PK1 Cells; Perylene; Phloroglucinol; Plant Extracts; Rifampin; Swine; Terpenes; Transfection | 2005 |
Effects of the antidepressant St. John's wort (Hypericum perforatum) on rat and human vas deferens contractility.
Topics: Animals; Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Dose-Response Relationship, Drug; Ejaculation; Humans; Hypericum; Isometric Contraction; Male; Muscle, Smooth; Orgasm; Perylene; Phloroglucinol; Rats; Terpenes; Tissue Culture Techniques; Vas Deferens | 2005 |
Single-drop liquid-phase microextraction for the determination of hypericin, pseudohypericin and hyperforin in biological fluids by high performance liquid chromatography.
Topics: Anthracenes; Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Hydrogen-Ion Concentration; Osmolar Concentration; Perylene; Phloroglucinol; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Terpenes | 2005 |
Quantitative analysis of the major constituents of St John's wort with HPLC-ESI-MS.
Topics: Anthracenes; Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Hypericum; Perylene; Phloroglucinol; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Terpenes | 2005 |
Approach to novel functional foods for stress control 4. Regulation of serotonin transporter by food factors.
Topics: Animals; Anthracenes; Biflavonoids; Bridged Bicyclo Compounds; Carrier Proteins; Cell Differentiation; Cell Line; Cell Lineage; Cells, Cultured; Fluoxetine; Fluvoxamine; Food; Hypericum; Ligands; Macrophages; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Osteoclasts; Perylene; Phloroglucinol; Plant Extracts; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Recombinant Proteins; Serotonin; Stress, Physiological; Terpenes; Time Factors | 2005 |
Comparison of methods for the exhaustive extraction of hypericins, flavonoids, and hyperforin from Hypericum perforatum L.
Topics: Anthracenes; Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Flavonoids; Hypericum; Mass Spectrometry; Perylene; Phloroglucinol; Sonication; Terpenes | 2006 |
A mechanistic study on altered pharmacokinetics of irinotecan by St. John's wort.
Topics: Animals; Anthracenes; Antineoplastic Agents, Phytogenic; Bridged Bicyclo Compounds; Camptothecin; Cell Line, Tumor; Cell Proliferation; Glucuronides; Hypericum; Irinotecan; Male; Microsomes, Liver; Perylene; Phloroglucinol; Plant Extracts; Quercetin; Rats; Rats, Sprague-Dawley; Terpenes | 2007 |
The main components of St John's Wort inhibit low-density lipoprotein atherogenic modification: a beneficial "side effect" of an OTC antidepressant drug?
Topics: Anthracenes; Antidepressive Agents; Antioxidants; Atherosclerosis; Bridged Bicyclo Compounds; Cells, Cultured; Chromatography, High Pressure Liquid; Circular Dichroism; Depression; Drug Evaluation, Preclinical; Endothelial Cells; Humans; Hypericum; Lipoproteins, LDL; Malondialdehyde; Mass Spectrometry; Molecular Structure; Nonprescription Drugs; Oxidation-Reduction; Peroxidase; Perylene; Phloroglucinol; Phytotherapy; Protein Binding; Structure-Activity Relationship; Terpenes; Thiobarbituric Acid Reactive Substances; Thromboplastin; Tyrosine; Umbilical Veins | 2007 |
Topical anti-inflammatory activity of extracts and compounds from Hypericum perforatum L.
Topics: Administration, Topical; Animals; Anthracenes; Anti-Inflammatory Agents; Bridged Bicyclo Compounds; Croton Oil; Dose-Response Relationship, Drug; Edema; Flavonoids; Flowers; Hypericum; Inhibitory Concentration 50; Male; Mice; Perylene; Phloroglucinol; Phytotherapy; Plant Extracts; Plants, Medicinal; Terpenes | 2007 |
Variability in PXR-mediated induction of CYP3A4 by commercial preparations and dry extracts of St. John's wort.
Topics: Anthracenes; Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Constitutive Androstane Receptor; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Flavonoids; Humans; Hypericum; Perylene; Phloroglucinol; Plant Extracts; Pregnane X Receptor; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Response Elements; Tablets; Terpenes; Transcription Factors; Transfection; Tumor Cells, Cultured | 2007 |
Hypericin and hyperforin production in St. John's wort in vitro culture: influence of saccharose, polyethylene glycol, methyl jasmonate, and Agrobacterium tumefaciens.
Topics: Acetates; Agrobacterium tumefaciens; Anthracenes; Bridged Bicyclo Compounds; Cyclopentanes; Hypericum; Oxylipins; Perylene; Phloroglucinol; Polyethylene Glycols; Seeds; Sucrose; Terpenes | 2007 |
Inhibition of prostaglandin E(2) production by anti-inflammatory hypericum perforatum extracts and constituents in RAW264.7 Mouse Macrophage Cells.
Topics: Animals; Anti-Inflammatory Agents; Bridged Bicyclo Compounds; Cell Death; Cells, Cultured; Dinoprostone; Flavonoids; Hypericum; Light; Macrophages; Mice; Perylene; Phloroglucinol; Plant Extracts; Terpenes | 2007 |
Protective effects of St. John's wort extract and its component hyperforin against cytokine-induced cytotoxicity in a pancreatic beta-cell line.
Topics: Animals; Anthracenes; Antineoplastic Agents; Apoptosis; Bridged Bicyclo Compounds; Cell Line, Tumor; Humans; Hypericum; Insulin; Insulin Secretion; Insulin-Secreting Cells; Interferon-gamma; Interleukin-1beta; Male; NF-kappa B; Nitric Oxide Synthase Type II; Perylene; Phloroglucinol; Plant Extracts; Rats; Rats, Sprague-Dawley; STAT1 Transcription Factor; Terpenes; Tumor Necrosis Factor-alpha | 2008 |
Bioactive constituent production in St. John's Wort in vitro hairy roots. Regenerated plant lines.
Topics: Anthracenes; Bridged Bicyclo Compounds; Chlorogenic Acid; Hypericum; Perylene; Phloroglucinol; Plant Extracts; Plant Roots; Plants, Genetically Modified; Terpenes; Transformation, Genetic | 2008 |
Pseudohypericin and hyperforin in Hypericum perforatum from Northern Turkey: variation among populations, plant parts and phenological stages.
Topics: Bridged Bicyclo Compounds; Climate; Geography; Hypericum; Perylene; Phloroglucinol; Plant Leaves; Plant Stems; Plant Structures; Population Dynamics; Seasons; Terpenes; Turkey | 2008 |
Involvement of serotoninergic 5-HT1A/2A, alpha-adrenergic and dopaminergic D1 receptors in St. John's wort-induced prepulse inhibition deficit: a possible role of hyperforin.
Topics: Animals; Anthracenes; Apoptosis; Bridged Bicyclo Compounds; DNA Fragmentation; Drugs, Chinese Herbal; Hypericum; Inhibition, Psychological; Male; Mice; Perylene; Phloroglucinol; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Receptors, Dopamine D1; Reflex, Acoustic; Reflex, Startle; Serotonin 5-HT1 Receptor Antagonists; Serotonin 5-HT2 Receptor Antagonists; Terpenes | 2009 |
Impact of the haplotypes of the human pregnane X receptor gene on the basal and St John's wort-induced activity of cytochrome P450 3A4 enzyme.
Topics: Anthracenes; Area Under Curve; Bridged Bicyclo Compounds; Cytochrome P-450 CYP3A; Female; Haplotypes; Humans; Hypericum; Male; Perylene; Phloroglucinol; Plant Preparations; Pregnane X Receptor; Receptors, Steroid; Terpenes; Young Adult | 2009 |
Study of dynamic accumulation of secondary metabolites in three subspecies of Hypericum perforatum.
Topics: Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Flavonoids; Flowers; Hypericum; Perylene; Phloroglucinol; Plant Extracts; Plant Leaves; Reference Standards; Species Specificity; Terpenes | 2010 |
Chemical constituents of Hypericum adenotrichum Spach, an endemic Turkish species.
Topics: Anthracenes; Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Hypericum; Kaempferols; Perylene; Phloroglucinol; Quercetin; Terpenes; Turkey | 2009 |
Secondary metabolites of Hypericum confertum and their possible chemotaxonomic significance.
Topics: Anthracenes; Apigenin; Biflavonoids; Bridged Bicyclo Compounds; Chlorogenic Acid; Hypericum; Perylene; Phloroglucinol; Plant Components, Aerial; Quercetin; Rutin; Terpenes | 2010 |
Pharmacological studies on Hypericum perforatum fractions and constituents.
Topics: Animals; Anthracenes; Calcium; Calcium Channel Blockers; Dose-Response Relationship, Drug; Female; Guinea Pigs; Hypericum; In Vitro Techniques; Male; Perylene; Phloroglucinol; Phosphodiesterase Inhibitors; Plant Extracts; Quercetin; Rabbits; Terpenes; Verapamil | 2011 |
Isolation and purification of series bioactive components from Hypericum perforatum L. by counter-current chromatography.
Topics: Anthracenes; Bridged Bicyclo Compounds; Chemical Fractionation; Chromatography, High Pressure Liquid; Countercurrent Distribution; Flavonols; Hypericum; Mass Spectrometry; Nuclear Magnetic Resonance, Biomolecular; Perylene; Phloroglucinol; Plant Extracts; Terpenes | 2011 |
In vitro photochemical and phototoxicological characterization of major constituents in St. John's Wort (Hypericum perforatum) extracts.
Topics: Anthracenes; Antidepressive Agents; Biological Products; Dermatitis, Phototoxic; DNA Damage; Enzyme Inhibitors; Hypericum; Light; Lipid Peroxidation; Perylene; Phloroglucinol; Plant Extracts; Reactive Oxygen Species; Terpenes | 2011 |
Investigating the effectiveness of St John's wort herb as an antimicrobial agent against mycobacteria.
Topics: Anthracenes; Anti-Bacterial Agents; Hypericum; Microbial Sensitivity Tests; Microscopy, Electron, Scanning; Mycobacterium; Perylene; Phloroglucinol; Plant Extracts; Terpenes | 2012 |
Secondary metabolites of Hypericum leptophyllum Hochst., an endemic Turkish species.
Topics: Anthracenes; Chlorogenic Acid; Chromatography, High Pressure Liquid; Flavonoids; Hypericum; Perylene; Phloroglucinol; Plant Components, Aerial; Plant Leaves; Plant Stems; Terpenes; Turkey | 2012 |
The pro-apoptotic and anti-invasive effects of hypericin-mediated photodynamic therapy are enhanced by hyperforin or aristoforin in HT-29 colon adenocarcinoma cells.
Topics: Adenocarcinoma; Anthracenes; Antineoplastic Agents; Apoptosis; Caspase 3; Cell Cycle Checkpoints; Cell Proliferation; Colonic Neoplasms; Drug Synergism; Enzyme Activation; Gene Expression Regulation, Neoplastic; HT29 Cells; Humans; Intracellular Space; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Membrane Potential, Mitochondrial; Neoplasm Invasiveness; Perylene; Phloroglucinol; Photochemotherapy; Reactive Oxygen Species; Terpenes | 2012 |
Effects of St John's wort and its active constituents, hypericin and hyperforin, on isolated rat urinary bladder.
Topics: Animals; Anthracenes; Carbachol; Cell Membrane; Dose-Response Relationship, Drug; Electric Stimulation; Glucose; Hypericum; Hypoxia; Ischemia; Male; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Parasympathomimetics; Perylene; Phloroglucinol; Plant Extracts; Potassium Chloride; Rats; Rats, Sprague-Dawley; Terpenes; Urinary Bladder; Urinary Bladder Diseases; Urinary Bladder, Overactive | 2012 |
St. John's Wort seed and feverfew flower extracts relieve painful diabetic neuropathy in a rat model of diabetes.
Topics: Animals; Anthracenes; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Flowers; Hyperalgesia; Hypericum; Perylene; Phloroglucinol; Phytotherapy; Plant Components, Aerial; Plant Extracts; Rats; Seeds; Sesquiterpenes; Tanacetum parthenium; Terpenes | 2014 |
Hypericum perforatum Reduces Paracetamol-Induced Hepatotoxicity and Lethality in Mice by Modulating Inflammation and Oxidative Stress.
Topics: Acetaminophen; Alanine Transaminase; Animals; Anthracenes; Anti-Inflammatory Agents; Antioxidants; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Glutathione; Hypericum; Inflammation; Male; Mice; Oxidative Stress; Perylene; Phloroglucinol; Plant Extracts; Plants, Medicinal; Quercetin; Rutin; Terpenes; Tumor Necrosis Factor-alpha | 2015 |
Effects of Hypericum perforatum extract and its main bioactive compounds on the cytotoxicity and expression of CYP1A2 and CYP2D6 in hepatic cells.
Topics: Anthracenes; Cell Line, Tumor; Cell Survival; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme Inhibitors; Drug Interactions; Enzyme Induction; Hepatocytes; Humans; Hypericum; Perylene; Phloroglucinol; Plant Extracts; RNA, Neoplasm; Terpenes; Tetrazolium Salts; Thiazoles | 2016 |
Drug membrane transporters and CYP3A4 are affected by hypericin, hyperforin or aristoforin in colon adenocarcinoma cells.
Topics: Adenocarcinoma; Anthracenes; Blotting, Western; Cell Line, Tumor; Colonic Neoplasms; Cytochrome P-450 CYP3A; Firefly Luciferin; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; Intracellular Space; Membrane Transport Proteins; Multidrug Resistance-Associated Protein 2; Neoplasm Proteins; Perylene; Phloroglucinol; Real-Time Polymerase Chain Reaction; Terpenes | 2016 |
Arbuscular mycorrhizal fungi altered the hypericin, pseudohypericin, and hyperforin content in flowers of Hypericum perforatum grown under contrasting P availability in a highly organic substrate.
Topics: Anthracenes; Flowers; Hypericum; Mycorrhizae; Perylene; Phloroglucinol; Phosphorus; Plant Extracts; Terpenes | 2017 |
Methodological aspects of biologically active compounds quantification in the genus Hypericum.
Topics: Anthracenes; Catechin; Chlorogenic Acid; Chromatography, High Pressure Liquid; Hypericum; Perylene; Phloroglucinol; Plant Extracts; Plant Leaves; Plant Stems; Quercetin; Rutin; Terpenes | 2018 |
The potential of hypericin and hyperforin for antiadhesion therapy to prevent metastasis of parental and oxaliplatin-resistant human adenocarcinoma cells (HT-29).
Topics: Adenocarcinoma; Anthracenes; Antineoplastic Combined Chemotherapy Protocols; Cell Adhesion; Cell Movement; Colonic Neoplasms; Drug Resistance, Neoplasm; HT29 Cells; Humans; Neoplasm Metastasis; Oxaliplatin; Perylene; Phloroglucinol; Terpenes | 2018 |
St John's wort extract influences membrane fluidity and composition of phosphatidylcholine and phosphatidylethanolamine in rat C6 glioblastoma cells.
Topics: Animals; Anthracenes; Cell Line, Tumor; Cell Membrane; Glioblastoma; Hydrocortisone; Hypericum; Membrane Fluidity; Perylene; Phloroglucinol; Phosphatidylethanolamines; Plant Extracts; Quercetin; Rats; Receptors, Adrenergic, beta-1; Signal Transduction; Terpenes | 2019 |
Novel Insights into the Effect of Hyperforin and Photodynamic Therapy with Hypericin on Chosen Angiogenic Factors in Colorectal Micro-Tumors Created on Chorioallantoic Membrane.
Topics: Angiogenesis Inducing Agents; Animals; Anthracenes; Biomarkers; Cell Line, Tumor; Chick Embryo; Chorioallantoic Membrane; Colorectal Neoplasms; Disease Models, Animal; Gene Expression; Humans; Neovascularization, Pathologic; Perylene; Phloroglucinol; Photochemotherapy; Photosensitizing Agents; Terpenes | 2019 |
Variability of Hypericins and Hyperforin in Hypericum Species from the Sicilian Flora.
Topics: Anthracenes; Hypericum; Perylene; Phloroglucinol; Sicily; Species Specificity; Terpenes | 2020 |
Development of new and validated HPTLC methods for the qualitative and quantitative analysis of hyperforin, hypericin and hyperoside contents in Hypericum species.
Topics: Anthracenes; Chromatography, Thin Layer; Hypericum; Perylene; Phloroglucinol; Plant Extracts; Quercetin; Terpenes | 2022 |