Compounds > perphenazine

perphenazine and phenobarbital

perphenazine has been researched along with phenobarbital in 27 studies

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-199014 (51.85)18.7374
1990's2 (7.41)18.2507
2000's8 (29.63)29.6817
2010's3 (11.11)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Duffy, EM; Jorgensen, WL1
Topliss, JG; Yoshida, F1
Carrupt, PA; Martel, S; Ottaviani, G1
Lombardo, F; Obach, RS; Waters, NJ1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Deliconstantinos, G; Tsakiris, S1
Inoki, R; Otori, K; Yamamoto, I1
Ban, TA; Noe, W; St Jean, A; Sterlin, C1
Loprete, FP; Palm, C1
Ibrahim, I; Sulman, FG; Weller, CP1
Elliott, RC; Quilliam, JP1
Farias, RN; Luly, P; Spinedi, A1
Guan, FY; Luo, Y; Wu, HF1
RIESE, JA1
CASEY, JF; HOLLISTER, LE; KLETT, CJ; LASKY, JJ1
PLOTNIKOFF, NP1
PLOTNIKOFF, N1
MARKS, J1
MAASSJENSEN, N; PARADABRAVO, F1
GOLDSTEIN, L; MURPHREE, HB; PFEIFFER, CC; SUGERMAN, AA1
BAN, TA; LEHMANN, HE1
Ghoreishi, A1

Reviews

2 review(s) available for perphenazine and phenobarbital

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Does the fluidity of the lipid environment modulate membrane-bound acetylcholinesterase? Effects of temperature, membrane composition and amphiphiles.
    Biochemical pharmacology, 1993, Nov-02, Volume: 46, Issue:9

    Topics: Acetylcholinesterase; Animals; Blood Platelets; Cell Membrane; Erythrocyte Membrane; Humans; Ketamine; Membrane Fluidity; Membrane Lipids; Perphenazine; Phenobarbital; Procaine; Synaptic Membranes; Temperature

1993

Trials

2 trial(s) available for perphenazine and phenobarbital

ArticleYear
Clinical studies with propericiazine (R.P. 8909).
    Diseases of the nervous system, 1967, Volume: 28, Issue:8

    Topics: Acute Disease; Adolescent; Adult; Aged; Association; Behavior; Chlorpromazine; Chronic Disease; Clinical Trials as Topic; Drug Synergism; Epilepsy; Female; Flicker Fusion; Humans; Imipramine; Injections, Intramuscular; Intellectual Disability; Male; Mental Disorders; Methylphenidate; Middle Aged; Nicotinic Acids; Perphenazine; Phenobarbital; Phenothiazines; Promethazine; Psychological Tests; Psychophysiology; Reaction Time; Schizophrenia; Thioridazine; Tranquilizing Agents; Tranylcypromine; Trifluoperazine

1967
Sleep in psychotic patients: a comparative clinical study.
    International journal of neuropsychiatry, 1967, Volume: 3, Issue:6

    Topics: Amitriptyline; Anxiety Disorders; Clinical Trials as Topic; Depression; Humans; Hypnotics and Sedatives; Middle Aged; Perphenazine; Phenobarbital; Sleep

1967

Other Studies

23 other study(ies) available for perphenazine and phenobarbital

ArticleYear
Prediction of drug solubility from Monte Carlo simulations.
    Bioorganic & medicinal chemistry letters, 2000, Jun-05, Volume: 10, Issue:11

    Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility

2000
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
In silico and in vitro filters for the fast estimation of skin permeation and distribution of new chemical entities.
    Journal of medicinal chemistry, 2007, Feb-22, Volume: 50, Issue:4

    Topics: Humans; Membranes, Artificial; Models, Biological; Models, Molecular; Octanols; Permeability; Pharmaceutical Preparations; Skin Absorption; Water

2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
    Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21

    Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
    Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3

    Topics:

2008
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
Differential effect of anionic and cationic drugs on the synaptosome-associated acetylcholinesterase activity of dog brain.
    The Biochemical journal, 1985, Jul-01, Volume: 229, Issue:1

    Topics: Acetylcholinesterase; Animals; Antidepressive Agents; Barbiturates; Brain; Dogs; Imipramine; Perphenazine; Phenobarbital; Primidone; Synaptosomes; Trifluoperazine

1985
Pharmacological studies on antagonists against nicotine-induced convulsions and death.
    Japanese journal of pharmacology, 1966, Volume: 16, Issue:4

    Topics: Animals; Anticonvulsants; Chlorpromazine; Drug Antagonism; Female; Ganglionic Blockers; Hexamethonium Compounds; Histamine H1 Antagonists; Male; Meprobamate; Mice; Nicotine; Parasympatholytics; Perphenazine; Phenobarbital; Phentolamine; Reserpine; Seizures; Sympatholytics; Thiazoles; Tolazoline; Tranquilizing Agents; Urea

1966
Analgesic profile of tranquillizers in multiple screening tests in mice.
    Archives internationales de pharmacodynamie et de therapie, 1968, Volume: 176, Issue:1

    Topics: Acetaminophen; Aminopyrine; Analgesics; Animals; Aspirin; Chlorpromazine; Codeine; Diazepam; Diphenhydramine; Electric Stimulation; Haloperidol; Hot Temperature; Hydroxyzine; Imipramine; Isocarboxazid; Male; Meprobamate; Mice; Morphine; Perphenazine; Phenobarbital; Phenothiazines; Promazine; Promethazine; Reserpine; Tetrabenazine; Thiopental; Time Factors; Tranquilizing Agents

1968
Centrally-active drugs and the discharge rate of spontaneously occurring action potentials in the superior cervical trunk of the cat.
    British journal of pharmacology, 1968, Volume: 34, Issue:3

    Topics: Action Potentials; Animals; Cats; Ganglia, Autonomic; Hydroxyzine; Perphenazine; Phenobarbital

1968
[A systematic screening and identification method for 29 central nervous system drugs in body fluid by high performance capillary electrophoresis].
    Yao xue xue bao = Acta pharmaceutica Sinica, 1997, Volume: 32, Issue:5

    Topics: Central Nervous System Agents; Doxepin; Electrophoresis, Capillary; Gastric Juice; Humans; Perphenazine; Phenobarbital

1997
Prantal with phenobarbital or with trilafon in gastrointestinal diseases.
    The American journal of gastroenterology, 1958, Volume: 30, Issue:5

    Topics: Gastrointestinal Diseases; Parasympatholytics; Perphenazine; Phenobarbital; Piperidines

1958
Treatment of schizophrenic reactions with phenothiazine derivatives. A comparative study of chlorpromazine, triflupromazine, mepazine, prochlorperazine, perphenazine, and phenobarbital.
    The American journal of psychiatry, 1960, Volume: 117

    Topics: Antipsychotic Agents; Chlorpromazine; Perphenazine; Phenobarbital; Phenothiazines; Prochlorperazine; Schizophrenia; Tranquilizing Agents; Triflupromazine

1960
EFFECT OF PSYCHOACTIVE DRUGS ON ESCAPE FROM AUDIOGENIC SEIZURES.
    Archives internationales de pharmacodynamie et de therapie, 1963, Oct-01, Volume: 145

    Topics: Behavior, Animal; Chlorpromazine; Epilepsy; Imipramine; Mice; Pentobarbital; Perphenazine; Pharmacology; Phenobarbital; Psychotropic Drugs; Research; Seizures; Sound; Triflupromazine

1963
EFFECT OF NEUROTROPIC DRUGS ON A NON-CONDITIONED AVOIDANCE RESPONSE.
    Archives internationales de pharmacodynamie et de therapie, 1963, Oct-01, Volume: 145

    Topics: Animals; Avoidance Learning; Behavior, Animal; Biological Assay; Chlorpromazine; Histamine H1 Antagonists; Imipramine; Muscle Relaxants, Central; Noise; Perphenazine; Phenobarbital; Prochlorperazine; Rats; Research; Tranquilizing Agents; Trifluoperazine; Triflupromazine

1963
PREDRUG BEHAVIOR AS A PREDICTOR OF RESPONSE TO PHENOTHIAZINES AMONG SCHIZOPHRENICS.
    The Journal of nervous and mental disease, 1963, Volume: 137

    Topics: Antipsychotic Agents; Chlorpromazine; Humans; Perphenazine; Phenobarbital; Phenothiazines; Prochlorperazine; Projective Techniques; Schizophrenia; Triflupromazine

1963
[ACUTE POISONINGS BY PSYCHOPHARMACOLOGICAL AGENTS IN CHILDHOOD].
    Revista chilena de pediatria, 1964, Volume: 35

    Topics: Amphetamine; Aspirin; Child; Chlordiazepoxide; Chlorothiazide; Chlorpromazine; Chlorprothixene; Fluphenazine; Hydantoins; Infant; Perphenazine; Phenmetrazine; Phenobarbital; Reserpine; Toxicology; Triflupromazine

1964
TIME-SERIES, FREQUENCY ANALYSIS, AND ELECTROGENESIS OF THE EEGS OF NORMALS AND PSYCHOTICS BEFORE AND AFTER DRUGS.
    The American journal of psychiatry, 1965, Volume: 121

    Topics: Amphetamine; Antidepressive Agents; Barbiturates; Biomedical Research; Caffeine; Central Nervous System Stimulants; Chlordiazepoxide; Chlorpromazine; Deanol; Drug Therapy; Electroencephalography; Lysergic Acid Diethylamide; Meprobamate; Orphenadrine; Pentobarbital; Perphenazine; Pharmacology; Phenobarbital; Placebos; Schizophrenia; Statistics as Topic; Tranquilizing Agents

1965
SKIN PIGMENTATION, A RARE SIDE EFFECT OF CHLORPROMAZINE.
    Canadian Psychiatric Association journal, 1965, Volume: 10

    Topics: Chemical Phenomena; Chemistry; Chlorpromazine; Diagnosis, Differential; Drug Therapy; Epilepsy; Eye Manifestations; Intellectual Disability; Melanins; Melanosis; Pathology; Perphenazine; Phenobarbital; Phenylalanine; Photosensitivity Disorders; Pigmentation Disorders; Prochlorperazine; Schizophrenia; Skin Pigmentation; Toxicology

1965
A somatic type delusional disorder secondary to peripheral neuropathy: a case report.
    Psychiatria Danubina, 2008, Volume: 20, Issue:1

    Topics: Adult; Amitriptyline; Biperiden; Brachial Plexus; Delusions; Drug Overdose; Drug Therapy, Combination; Foreign Bodies; Hallucinations; Hand; Humans; Male; Paresis; Perphenazine; Phenobarbital; Psychiatric Status Rating Scales; Somatoform Disorders; Substance-Related Disorders

2008