perphenazine and morphine

perphenazine has been researched along with morphine in 27 studies

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-199012 (44.44)18.7374
1990's2 (7.41)18.2507
2000's8 (29.63)29.6817
2010's5 (18.52)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Carrupt, PA; Crivori, P; Cruciani, G; Testa, B1
Duffy, EM; Jorgensen, WL1
Topliss, JG; Yoshida, F1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY1
Lombardo, F; Obach, RS; Waters, NJ1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M1
Boulouard, M; Bureau, R; Butt-Gueulle, S; Dauphin, F; Daveu, C; Duchatelle, P; Dumuis, A; Lelong-Boulouard, V; Lemaître, S; Lepailleur, A; Lezoualc'h, F; Pfeiffer, B; Rault, S1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Fruensgaard, K1
Robinson, JH; Wang, SC1
Kandel, DA; Schuster, CR1
Dundee, JW; Loan, WB; Morrison, JD1
Bella, DD; Bonfitto, M; Santini, V1
Hirano, GM; Hudes, ET; Marans, HJ; Scott, AC; Shine, K1
Kowa, Y; Nakama, M; Ochiai, T1
Spoerlein, MT; VanderWende, C1
Araki, Y; Gomita, Y; Ogawa, N; Ueki, S; Watanabe, S1
Dhawan, KN; Gupta, GP; Jaju, BP; Srimal, RC1
Ibrahim, I; Sulman, FG; Weller, CP1
Haas, H; Jantos, W1
Cheng, DC; Katz, J; Kavanagh, BP; Saccomanno, PM; Sandler, AN1
DANDIYA, PC; MENON, MK1
Bagcivan, I; Gursoy, S; Ozdemir, E1

Reviews

1 review(s) available for perphenazine and morphine

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

3 trial(s) available for perphenazine and morphine

ArticleYear
A comparison of the efficacy of cyclizine and perhenazine in reducing the emetic effects of morphine and pethidine.
    British journal of clinical pharmacology, 1975, Volume: 2, Issue:1

    Topics: Antiemetics; Cyclizine; Drug Evaluation; Humans; Meperidine; Morphine; Perphenazine; Preanesthetic Medication

1975
A comparison of morphine-perphenazine and midazolam on preoperative sedation and arterial oxygen saturation.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1991, Volume: 38, Issue:2

    Topics: Adult; Double-Blind Method; Female; Humans; Male; Midazolam; Middle Aged; Morphine; Oxygen; Perphenazine; Preanesthetic Medication

1991
Comparison of lorazepam alone vs lorazepam, morphine, and perphenazine for cardiac premedication.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1997, Volume: 44, Issue:2

    Topics: Aged; Anti-Anxiety Agents; Double-Blind Method; Female; Hemodynamics; Hemoglobins; Humans; Lorazepam; Male; Middle Aged; Morphine; Myocardial Ischemia; Perphenazine; Preanesthetic Medication; Prospective Studies; Respiration

1997

Other Studies

23 other study(ies) available for perphenazine and morphine

ArticleYear
Predicting blood-brain barrier permeation from three-dimensional molecular structure.
    Journal of medicinal chemistry, 2000, Jun-01, Volume: 43, Issue:11

    Topics: Blood-Brain Barrier; Databases, Factual; Models, Chemical; Molecular Conformation; Multivariate Analysis; Permeability; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Prediction of drug solubility from Monte Carlo simulations.
    Bioorganic & medicinal chemistry letters, 2000, Jun-05, Volume: 10, Issue:11

    Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility

2000
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
    Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5

    Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution

2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
    Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21

    Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship

2008
Novel antagonists of serotonin-4 receptors: synthesis and biological evaluation of pyrrolothienopyrazines.
    Bioorganic & medicinal chemistry, 2009, Mar-15, Volume: 17, Issue:6

    Topics: Animals; Chlorocebus aethiops; COS Cells; Humans; Indoles; Models, Molecular; Molecular Structure; Pyrazines; Radioligand Assay; Serotonin 5-HT4 Receptor Antagonists; Serotonin Antagonists; Sulfonamides

2009
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
Withdrawal psychosis: a study of 30 consecutive cases.
    Acta psychiatrica Scandinavica, 1976, Volume: 53, Issue:2

    Topics: Adult; Aged; Analgesics; Antipsychotic Agents; Barbiturates; Benzodiazepines; Codeine; Female; Humans; Male; Medazepam; Meprobamate; Methaqualone; Middle Aged; Morphine; Perphenazine; Psychoses, Alcoholic; Psychotic Disorders; Sex Factors; Substance Withdrawal Syndrome

1976
Unit activity of limbic system neurons: effects of morphine, diazepam and neuroleptic agents.
    Brain research, 1979, Apr-20, Volume: 166, Issue:1

    Topics: Animals; Antipsychotic Agents; Cats; Chlorpromazine; Diazepam; Evoked Potentials; Female; Gyrus Cinguli; Haloperidol; Hypothalamus; Limbic System; Male; Morphine; Neurons; Perphenazine; Septum Pellucidum

1979
An investigation of nalorphine and perphenazine as negative reinforcers in an escape paradigm.
    Pharmacology, biochemistry, and behavior, 1977, Volume: 6, Issue:1

    Topics: Animals; Escape Reaction; Haplorhini; Humans; Macaca mulatta; Morphine; Morphine Dependence; Nalorphine; Perphenazine; Reaction Time; Self Administration; Time Factors

1977
Study of the action of some centrally acting drugs on the EEG and on a conditioned avoidance reflex in the rabbit.
    Archives internationales de pharmacodynamie et de therapie, 1975, Volume: 217, Issue:1

    Topics: Animals; Avoidance Learning; Benactyzine; Diazepam; Electrodes, Implanted; Electroencephalography; Ethanolamines; Male; Morphine; Perphenazine; Rabbits; Reflex; Stereoisomerism

1975
Effects of psychotropic drugs on emotional behavior: exploratory behavior of naive rats in holed open field.
    Japanese journal of pharmacology, 1972, Volume: 22, Issue:6

    Topics: Animals; Antidepressive Agents; Chlordiazepoxide; Chlorpromazine; Defecation; Diazepam; Emotions; Exploratory Behavior; Hallucinogens; Haloperidol; Imipramine; Male; Meprobamate; Mescaline; Methamphetamine; Methods; Morphine; Motor Activity; Perphenazine; Rats; Time Factors; Tranquilizing Agents

1972
Role of dopaminergic receptors in morphine analgesia and tolerance.
    Research communications in chemical pathology and pharmacology, 1973, Volume: 5, Issue:1

    Topics: Amantadine; Analgesia; Animals; Apomorphine; Dibenzothiazepines; Dopamine; Drug Synergism; Drug Tolerance; Male; Mice; Mice, Inbred Strains; Morphine; Perphenazine; Phenoxybenzamine; Receptors, Adrenergic; Serine; Spiro Compounds

1973
[Behavioral and neuopharmacological effects of flupentixol].
    Igaku kenkyu. Acta medica, 1971, Volume: 41, Issue:5

    Topics: Anesthetics; Animals; Antiemetics; Behavior, Animal; Body Temperature; Catalepsy; Cats; Central Nervous System; Chlorpromazine; Drug Synergism; Electroencephalography; Ethanol; Humans; Male; Mescaline; Methamphetamine; Morphine; Muscle Relaxants, Central; Perphenazine; Piperazines; Rats; Reflex; Reserpine; Seizures; Sleep; Spinal Cord; Tranquilizing Agents; Xanthenes

1971
Effect of lysergic acid diethylamide (LSD-25) on morphine induced bradycardia.
    Japanese journal of pharmacology, 1967, Volume: 17, Issue:4

    Topics: Animals; Bradycardia; Chlorpromazine; Electrocardiography; Female; Heart Rate; Lysergic Acid Diethylamide; Male; Morphine; Perphenazine; Phenothiazines; Rabbits; Tachycardia

1967
Analgesic profile of tranquillizers in multiple screening tests in mice.
    Archives internationales de pharmacodynamie et de therapie, 1968, Volume: 176, Issue:1

    Topics: Acetaminophen; Aminopyrine; Analgesics; Animals; Aspirin; Chlorpromazine; Codeine; Diazepam; Diphenhydramine; Electric Stimulation; Haloperidol; Hot Temperature; Hydroxyzine; Imipramine; Isocarboxazid; Male; Meprobamate; Mice; Morphine; Perphenazine; Phenobarbital; Phenothiazines; Promazine; Promethazine; Reserpine; Tetrabenazine; Thiopental; Time Factors; Tranquilizing Agents

1968
[Modification of central mechanisms of action by anticholinergics].
    Arzneimittel-Forschung, 1969, Volume: 19, Issue:1

    Topics: Aggression; Amphetamine; Animals; Apomorphine; Atropine; Biperiden; Bridged-Ring Compounds; Central Nervous System; Chlorpromazine; Depression, Chemical; Drug Synergism; Esters; Female; Hexobarbital; Humans; Imipramine; Male; Mice; Morphine; Nicotine; Parasympatholytics; Pentylenetetrazole; Perphenazine; Rats; Stimulation, Chemical; Strychnine; Tremorine

1969
Studies on central nervous system depressants. (III). Influence of some tranquillizing agents on morphine analgesia.
    Archives internationales de pharmacodynamie et de therapie, 1963, Jan-01, Volume: 141

    Topics: Amides; Analgesia; Carisoprodol; Chlorpromazine; Meprobamate; Morphine; Perphenazine; Phenothiazines; Piperidines; Prochlorperazine; Propylene Glycols; Rauwolfia; Reserpine; Thioridazine; Tranquilizing Agents

1963
Role of D₁/D₂ dopamin receptors antagonist perphenazine in morphine analgesia and tolerance in rats.
    Bosnian journal of basic medical sciences, 2013, Volume: 13, Issue:2

    Topics: Analgesia; Animals; Benzazepines; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Drug Tolerance; Male; Morphine; Pain; Perphenazine; Rats; Rats, Wistar; Receptors, Dopamine D1; Salicylamides; Time Factors

2013