perphenazine and desipramine

perphenazine has been researched along with desipramine in 38 studies

Research

Studies (38)

Timeframe	Studies, this research(%)	All Research%
pre-1990	21 (55.26)	18.7374
1990's	1 (2.63)	18.2507
2000's	9 (23.68)	29.6817
2010's	7 (18.42)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Chiang, GH; Unger, SH	1
Carrupt, PA; Crivori, P; Cruciani, G; Testa, B	1
Duffy, EM; Jorgensen, WL	1
Topliss, JG; Yoshida, F	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	1
Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P	1
Lombardo, F; Obach, RS; Waters, NJ	1
Ahman, M; Holmén, AG; Wan, H	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Henry, BW; Overall, JE; Woodward, JA	1
Gram, LF	1
Jatlow, PI; Nelson, JC; Price, LH	1
Frisk-Holmberg, M; van der Kleijn, E	1
Mandell, AJ; Spooner, CE; Wallach, MB; Winters, WD	2
Kodama, T; Matsukado, Y; Shimizu, H; Suzuki, T; Tanaka, S	1
Green, AL	1
Dixon, AK	1
Komissarov, IV; Talalaenko, AN; Zin'kovskaia, LIa	1
Christiansen, J; Gram, LF; Overo, KF	1
Arbitman, R; Ban, TA; Jarrold, L; Lehmann, HE; Sterlin, C; Yurtcu, A	1
Garriott, JC; Stolman, A	1
Iriye, TT; Simmonds, FA	1
Oates, JA; Shand, DG	1
Núnek, K	1
Foxwell, MH; Funderburk, WH; Hakala, MW	1
Bock, JL; Gray, S; Jatlow, PI; Nelson, JC	1
Cardinal, JA; Hill, AG; Midha, KK; Verbeeck, RK	1
Amore, M; Giordani, L; Giorgetti, G; Zazzeri, N	1
TOFTE, F	1
Gowda, R; Kuzu, OF; Noory, MA; Robertson, GP	1

Reviews

2 review(s) available for perphenazine and desipramine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
[Pharmacological treatment of delusional depression]. Minerva psichiatrica, 1996, Volume: 37, Issue:1 Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Delusions; Depressive Disorder; Desipramine; Drug Therapy, Combination; Haloperidol; Humans; Perphenazine; Psychotic Disorders	1996

Trials

1 trial(s) available for perphenazine and desipramine

Article	Year
Protrptyline in the treatment of chronic schizophrenic patients. Current therapeutic research, clinical and experimental, 1970, Volume: 12, Issue:3 Topics: Adolescent; Adult; Clinical Trials as Topic; Desipramine; Dibenzocycloheptenes; Female; Humans; Male; Mental Disorders; Middle Aged; Perphenazine; Psychiatric Status Rating Scales; Schizophrenia	1970

Other Studies

35 other study(ies) available for perphenazine and desipramine

Article	Year
Octanol-physiological buffer distribution coefficients of lipophilic amines by reversed-phase high-performance liquid chromatography and their correlation with biological activity. Journal of medicinal chemistry, 1981, Volume: 24, Issue:3 Topics: Amines; Animals; Buffers; Chromatography, High Pressure Liquid; Histamine Release; Lipid Metabolism; Octanols; Protein Binding; Rats; Serum Albumin, Bovine; Sodium-Potassium-Exchanging ATPase; Solubility; Structure-Activity Relationship	1981
Predicting blood-brain barrier permeation from three-dimensional molecular structure. Journal of medicinal chemistry, 2000, Jun-01, Volume: 43, Issue:11 Topics: Blood-Brain Barrier; Databases, Factual; Models, Chemical; Molecular Conformation; Multivariate Analysis; Permeability; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Prediction of drug solubility from Monte Carlo simulations. Bioorganic & medicinal chemistry letters, 2000, Jun-05, Volume: 10, Issue:11 Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility	2000
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability. Journal of medicinal chemistry, 2004, Mar-25, Volume: 47, Issue:7 Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs. Journal of medicinal chemistry, 2009, Mar-26, Volume: 52, Issue:6 Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry	2009
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors. Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:1 Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity	2013
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Patterns of symptom change in anxious depressed outpatients treated with different drugs. Diseases of the nervous system, 1975, Volume: 36, Issue:3 Topics: Amitriptyline; Antidepressive Agents; Anxiety; Chlordiazepoxide; Chlorpromazine; Depression; Desipramine; Diazepam; Drug Combinations; Fluphenazine; Humans; Imipramine; Mental Disorders; Nortriptyline; Perphenazine; Thioridazine; Thiothixene; Tranquilizing Agents; Trifluoperazine	1975
Effects of perphenazine on imipramine metabolism in man. Psychopharmacology communications, 1975, Volume: 1, Issue:2 Topics: Adult; Desipramine; Drug Interactions; Female; Glucuronates; Humans; Imipramine; Male; Middle Aged; Perphenazine; Schizophrenia; Time Factors	1975
Neuroleptic dose and desipramine concentrations during combined treatment of unipolar delusional depression. The American journal of psychiatry, 1986, Volume: 143, Issue:9 Topics: Administration, Oral; Adult; Aged; Delusions; Depressive Disorder; Desipramine; Drug Administration Schedule; Drug Therapy, Combination; Female; Haloperidol; Humans; Male; Middle Aged; Outcome and Process Assessment, Health Care; Perphenazine; Psychiatric Status Rating Scales	1986
The relationship between the lipophilic nature of tricyclic neuroleptics and antidepressants, and histamine release. European journal of pharmacology, 1972, Volume: 18, Issue:2 Topics: Amitriptyline; Animals; Antidepressive Agents; Cell Membrane Permeability; Chemical Phenomena; Chemistry; Chlorpromazine; Chlorprothixene; Clopenthixol; Desipramine; Fluphenazine; Histamine Release; Imipramine; Kinetics; Male; Mast Cells; Methotrimeprazine; Nortriptyline; Perphenazine; Phenothiazines; Prochlorperazine; Promazine; Promethazine; Rats; Solvents; Structure-Activity Relationship; Thioridazine; Tranquilizing Agents; Trifluoperazine	1972
A correlation of EEG, reticular multiple unit activity and gross behavior following various antidepressant agents in the cat. IV. Electroencephalography and clinical neurophysiology, 1969, Volume: 27, Issue:6 Topics: Amitriptyline; Animals; Antidepressive Agents; Behavior, Animal; Cats; Chlorpromazine; Desipramine; Electroencephalography; Electromyography; Evoked Potentials; Female; Imipramine; Male; Mesencephalon; Methamphetamine; Pargyline; Perphenazine; Reticular Formation; Seizures; Sleep; Wakefulness	1969
Effects of antidepressant drugs on wakefulness and sleep in the cat. Electroencephalography and clinical neurophysiology, 1969, Volume: 27, Issue:6 Topics: Amitriptyline; Animals; Antidepressive Agents; Cats; Chlorpromazine; Circadian Rhythm; Desipramine; Electromyography; Evoked Potentials; Female; Imipramine; Male; Mesencephalon; Methamphetamine; Pargyline; Perphenazine; Reticular Formation; Sleep; Sleep Stages; Time Factors; Wakefulness	1969
Stimulated formation of adenosine 3',5'-monophosphate by desipramine in brain slices. Biochimica et biophysica acta, 1971, Volume: 252, Issue:1 Topics: Adenine; Adenosine Triphosphate; Amitriptyline; Animals; Brain; Carbon Isotopes; Chlorpromazine; Cyclic AMP; Desipramine; Guinea Pigs; Histamine; Imipramine; Male; Norepinephrine; Perphenazine; Phentolamine; Phosphoric Monoester Hydrolases; Propranolol; Rats; Rats, Inbred Strains; Theophylline; Tritium; Veratrine	1971
Ionization constants and water solubilities of some aminoalkylphenothiazine tranquillizers and related compounds. The Journal of pharmacy and pharmacology, 1967, Volume: 19, Issue:1 Topics: Amitriptyline; Chemical Phenomena; Chemistry; Chlorpromazine; Desipramine; Hydrogen-Ion Concentration; Imipramine; Perphenazine; Phenothiazines; Prochlorperazine; Promethazine; Solubility; Thioridazine; Tranquilizing Agents; Trifluoperazine; Water	1967
Evidence of catecholamine mediation in the "aberrant" behaviour induced by lysergic acid diethylamide (LSD) in the rat. Experientia, 1968, Jul-15, Volume: 24, Issue:7 Topics: Animals; Behavior, Animal; Catecholamines; Chlorpromazine; Desipramine; Dibenzylchlorethamine; Disulfiram; Dopamine; Ethanolamines; Locomotion; Lysergic Acid Diethylamide; Male; Methysergide; Perphenazine; Phenoxybenzamine; Phenylalanine; Propranolol; Rats; Reserpine; Serotonin	1968
[Analysis of the monoaminergic mechanisms of the dorsal hippocampus actualizing conditioned avoidance reactions in rats]. Biulleten' eksperimental'noi biologii i meditsiny, 1974, Volume: 78, Issue:11 Topics: Animals; Avoidance Learning; Chlorpromazine; Conditioning, Classical; Depression, Chemical; Desipramine; Dihydroergotamine; Dopamine; Drug Interactions; Haloperidol; Hippocampus; Imipramine; Male; Motor Activity; Muscle Tonus; Norepinephrine; Perphenazine; Phentolamine; Rats; Reaction Time; Serotonin	1974
Pharmacokinetic interaction between neuroleptics and tricyclic antidepressants in the rat. Acta pharmacologica et toxicologica, 1974, Volume: 35, Issue:3 Topics: Animals; Brain; Carbon Radioisotopes; Chlorpromazine; Chromatography, Thin Layer; Desipramine; Dose-Response Relationship, Drug; Drug Interactions; Erythrocytes; Feces; Glucuronates; Heart; Imipramine; Injections, Intraperitoneal; Male; Nortriptyline; Perphenazine; Rats	1974
Detection of some psychotherapeutic drugs and their metabolites in urine. Clinical toxicology, 1971, Volume: 4, Issue:2 Topics: Amitriptyline; Amphetamine; Analgesics; Antidepressive Agents; Chlordiazepoxide; Chlorpromazine; Chromatography, Thin Layer; Desipramine; Diazepam; Fluphenazine; Haloperidol; Humans; Imipramine; Indicators and Reagents; Methadone; Perphenazine; Solvents; Thioridazine; Tranquilizing Agents; Trifluoperazine	1971
Effect of tranquilizers and antidepressants on glycogen phosphorylase of rat brain. Biochemical pharmacology, 1971, Volume: 20, Issue:8 Topics: Adenosine Monophosphate; Animals; Antidepressive Agents; Brain; Depression, Chemical; Desipramine; Dextroamphetamine; Female; Freezing; Glucosyltransferases; Iproniazid; Norepinephrine; Pargyline; Perphenazine; Phosphorylases; Prochlorperazine; Promazine; Promethazine; Rats; Receptors, Adrenergic; Reserpine; Tranquilizing Agents; Triflupromazine	1971
Metabolism of propranolol by rat liver microsomes and its inhibition by phenothiazine and tricyclic antidepressant drugs. Biochemical pharmacology, 1971, Volume: 20, Issue:7 Topics: Amitriptyline; Animals; Antidepressive Agents; Chlorpromazine; Desipramine; Imipramine; Kinetics; Liver; Male; Metabolism; Microsomes, Liver; NAD; NADP; Nitrogen; Nortriptyline; Perphenazine; Phenothiazines; Prochlorperazine; Promazine; Promethazine; Propranolol; Rats; Subcellular Fractions; Trifluoperazine; Triflupromazine	1971
[Current problems of endogenous depression]. Activitas nervosa superior, 1970, Jan-12, Volume: 12, Issue:1 Topics: Amitriptyline; Antidepressive Agents; Chlorpromazine; Convulsive Therapy; Depression; Desipramine; Fluphenazine; Humans; Imipramine; Methotrimeprazine; Nortriptyline; Perphenazine; Thioridazine	1970
Effects of psychotherapeutic drugs on hypothalamic- induced hissing in cats. Neuropharmacology, 1970, Volume: 9, Issue:1 Topics: Amitriptyline; Animals; Cats; Chlordiazepoxide; Chlorpromazine; Desipramine; Electric Stimulation; Female; Hypothalamus; Imipramine; Injections, Intraperitoneal; Male; Pentobarbital; Perphenazine; Tranquilizing Agents; Trifluoperazine; Vocalization, Animal	1970
Desipramine hydroxylation: variability and effect of antipsychotic drugs. Clinical pharmacology and therapeutics, 1983, Volume: 33, Issue:3 Topics: Adult; Aged; Antipsychotic Agents; Chromatography, Gas; Chromatography, High Pressure Liquid; Desipramine; Drug Interactions; Female; Humans; Hydroxylation; Male; Middle Aged; Perphenazine	1983
Binding of phenothiazine neuroleptics to plasma proteins. Biochemical pharmacology, 1983, Sep-01, Volume: 32, Issue:17 Topics: Antipsychotic Agents; Blood Proteins; Chlorpromazine; Desipramine; Humans; Kinetics; Perphenazine; Propranolol; Protein Binding; Salicylates; Salicylic Acid; Structure-Activity Relationship; Trifluoperazine; Tritium	1983
[LONG-TERM DRUG TREATMENT OF CRIMINALS. PRELIMINARY EXPERIENCES]. Ugeskrift for laeger, 1964, Jan-09, Volume: 126 Topics: Antidepressive Agents; Chlordiazepoxide; Criminals; Criminology; Denmark; Desipramine; Humans; Imipramine; Mental Disorders; Opipramol; Perphenazine	1964
Modulating cancer cell survival by targeting intracellular cholesterol transport. British journal of cancer, 2017, Aug-08, Volume: 117, Issue:4 Topics: Administration, Intravenous; Administration, Oral; Animals; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Autophagy; bcl-2-Associated X Protein; Biological Transport; Cell Survival; Cholesterol; Desipramine; Endocytosis; Endosomes; Female; Flupenthixol; Fluphenazine; Gene Expression Regulation; Gene Knockdown Techniques; HCT116 Cells; Homeostasis; Humans; Inhibitory Concentration 50; Liposomes; Lysosomes; MCF-7 Cells; Melanoma; Mice; Nortriptyline; Perphenazine; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; Sphingomyelin Phosphodiesterase; STAT3 Transcription Factor	2017