peroxynitrous acid has been researched along with tyrosine in 672 studies
| Studies (peroxynitrous acid) | Trials (peroxynitrous acid) | Recent Studies (post-2010) (peroxynitrous acid) | Studies (tyrosine) | Trials (tyrosine) | Recent Studies (post-2010) (tyrosine) |
|---|---|---|---|---|---|
| 3,303 | 21 | 1,230 | 44,273 | 846 | 8,225 |
| 3,303 | 21 | 1,230 | 50 | 0 | 20 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (0.15) | 18.2507 |
| 2000's | 454 (67.56) | 29.6817 |
| 2010's | 196 (29.17) | 24.3611 |
| 2020's | 21 (3.13) | 2.80 |
| Authors | Studies |
|---|---|
| Hiramoto, K; Kikugawa, K; Nakauchi, K; Tomiyama, S | 1 |
| Bradley, NJ; Bruckdorfer, KR; Jacobs, M; Khan, J; Low, SY; Naseem, KM; Sabetkar, M | 1 |
| Ali, SF; Imam, SZ; Islam, F; Itzhak, Y; Slikker, W | 1 |
| Chen, Q; Djaldatti, R; Giasson, BI; Ischiropoulos, H; Jackson-Lewis, V; Lee, VM; Przedborski, S; Souza, JM; Vila, M; Vukosavic, S | 1 |
| Romestand, B; Torreilles, J | 1 |
| Augusto, O; Giorgio, S; Linares, E; Mortara, RA; Santos, CX; Yamada, AT | 1 |
| Gieche, J; Grune, T; Klotz, LO; Rudeck, M; Sies, H | 1 |
| Besner, JG; Bouchard, JF; Cabassi, A; de Champlain, J; Dumont, EC; Girouard, H; Lamontagne, D; Le Jossec, M | 1 |
| Hirano, K; Hokari, S; Inoue, I; Katayama, S; Kawai, S; Komoda, T; Koyama, I; Matsunaga, T; Nakajima, T; Sonoda, M | 1 |
| Augusto, O; Lopes de Menezes, S | 1 |
| de Groot, H; Kirsch, M; Korth, HG; Lehnig, M; Sustmann, R | 1 |
| Bette, M; Dietzschold, B; Hooper, DC; Kean, RB; Mikheeva, T; Morimoto, K; Röhrenbeck, AM; Scott, GS; Spitsin, SV; Weihe, E | 1 |
| Boveris, A; Cadenas, E; Clementi, E; Melani, M; Moncada, S; Poderoso, JJ; Riobó, NA | 1 |
| de Lamirande, E; Gagnon, C; Herrero, MB | 1 |
| Kelpke, SS; Prince, CW; Reiff, D; Thompson, JA | 1 |
| Brodsky, S; Fujita, T; Goligorsky, MS; Nakao, A; Noiri, E; Ohno, M; Tsukahara, H; Uchida, K | 1 |
| Cobbs, CS; Gillespie, GY; Harkins, LE; MacMillan-Crow, LA; Merrick, BA; Samanta, M | 1 |
| Cross, CE; Eiserich, JP; Lopez, CL; Reddy, S; van der Vliet, A; Wong, PS | 1 |
| Cross, CE; Eiserich, JP; van der Vliet, A | 1 |
| Bando, T; Hasegawa, S; Isowa, N; Kawashima, M; Kondo, H; Nakamura, T; Toyokuni, S; Wada, H; Yoshimura, T | 1 |
| Hewett, SJ; Trackey, JL; Uliasz, TF | 1 |
| Lass, A; Mayer, B; Pfeiffer, S; Schmidt, K | 1 |
| Haramaki, N; Ikeda, H; Imaizumi, T; Murohara, T; Takajo, Y | 1 |
| Arteel, GE; Becker, K; Bohme, CC; Karplus, PA; Savvides, SN; Scheiwein, M; Schirmer, RH | 1 |
| Galiñanes, M; Matata, BM | 2 |
| Marino, G; Minetti, M; Pietraforte, D; Salzano, AM; Scorza, G | 1 |
| Claparols, C; Hoffmann, P; Périé, J; Soulère, L | 1 |
| Britton, S; Hernandez-Pando, RH; Leekassa, R; Negesse, Y; Schön, T; Sundqvist, T | 1 |
| Kalyanaraman, B; Klotz, LO; Schroeder, P; Sies, H; Zhang, H | 1 |
| Korbutt, GS; Lakey, JR; Mabley, JG; Rabinovitch, A; Rajotte, RV; Strynadka, K; Suarez-Pinzon, WL; Szabó, C | 1 |
| Choi, CR; Choi, JW; Jang, ES; Ju, C; Kim, HC; Kim, WK; Ko, KH; Shin, CY | 1 |
| Ahki, KM; Cruthirds, DL; MacMillan-Crow, LA; Sanders, PW; Thompson, JA | 1 |
| Gutiérrez-Martín, Y; Gutiérrez-Merino, C; Henao, F; Martín-Romero, FJ | 1 |
| Cohen, RA; Shi, C; Zou, MH | 1 |
| Kato, Y; Maruyama, W; Naoi, M; Sato, Y; Shamoto-Nagai, M; Tanaka, M; Yamamoto, T; Yi, H | 1 |
| Alonso, D; Bentura, ML; Castro-Blanco, S; Encinas, JM; Fernández, AP; Fernández-Vizarra, P; Richart, A; Rodrigo, J; Rodríguez, I; Ruíz-Cabello, J; Santacana, M; Serrano, J; Uttenthal, LO | 1 |
| Stadtman, ER | 1 |
| Boveris, AD; Cadenas, E; Poderoso, JJ; Riobó, NA; Schöpfer, FJ | 1 |
| Cimen, B; Ertabak, A; Karabicak, U; Türközkan, N; Unlü, A | 1 |
| Aratani, Y; Fukuyama, N; Hirabayashi, H; Koyama, H; Maeda, N; Nakazawa, H; Shinohara, Y; Takizawa, S | 1 |
| Kocis, JM; Kuo, WN; Webb, JK | 1 |
| Bruckdorfer, KR; Low, SY; Naseem, KM; Sabetkar, M | 2 |
| Borges, C; Geddes, T; Kreipke, C; Kuhn, DM; Liu, X; Sadidi, M; Watson, JT | 1 |
| Haginaka, J; Kagota, S; Kunitomo, M; Yamaguchi, Y | 1 |
| Folkerts, G; Habernickel, J; Muijsers, RB; Nijkamp, FP; Postma, DS; van der Veeken, A | 1 |
| Lai, HH; Yen, GC | 1 |
| da Rocha, FA; de Brum-Fernandes, AJ | 1 |
| Fakhrzadeh, L; Laskin, DL; Laskin, JD | 1 |
| Du, Y; Kern, TS; Miller, CM; Smith, MA | 1 |
| Fontana, M; Lucente, G; Pecci, L; Pinnen, F | 1 |
| Amanso, AM; Augusto, O; Bonini, MG; De Menezes, SL; Linares, E; Santos, CC | 1 |
| Dzierzega-Lecznar, A; Stepień, K; Wilczok, A; Wilczok, T; Zajdel, A | 1 |
| Hurst, JK | 1 |
| Britti, D; Caputi, AP; Centorrino, T; Ciccolo, A; Cuzzocrea, S; Dugo, L; Mazzon, E; Serraino, I; Thiemermann, C; Van de Loo, FA | 1 |
| Nagano, Y; Nakamura, S; Nakamura, T; Takahashi, T; Yamashita, H | 1 |
| Bhaumik, S; Khar, A; Mitra, R | 1 |
| Giannopoulou, E; Katsoris, P; Papadimitriou, E; Polytarchou, C | 1 |
| An, J; Camara, AK; Chen, Q; Hogg, N; Novalija, E; Riess, ML; Stowe, DF; Varadarajan, SG | 1 |
| Halliwell, B; Ketsawatsakul, U; Whiteman, M | 1 |
| Kocis, JM; Kuo, WN | 1 |
| Ponnappan, U; Soderberg, LS | 1 |
| Bishop, AE; Harjula, AL; Maasilta, PK; Polak, JM; Romanska, HM; Salminen, US | 1 |
| Beckman, JS | 2 |
| Ali, SF; Duhart, HM; Imam, SZ; Islam, F; Newport, GD; Slikker, W | 1 |
| Bagi, Z; Csiszar, A; Koller, A; Ungvari, Z | 1 |
| Albrecht, EW; Stegeman, CA; Tegzess, AM; Tiebosch, AT; van Goor, H | 1 |
| Di Stasi, AM; Macchia, G; Mallozzi, C; Maura, G; Minetti, M; Petrucci, TC | 1 |
| Chen, Q; Hertkorn, C; Ischiropoulos, H; Lightfoot, R; Lorch, S; Masuda, M; Ohshima, H; Pignatelli, B; Souza, J; Szabó, C; Virág, L; Weiss, M; Yermilov, V | 1 |
| Csont, T; Ferdinandy, P; Khadour, FH; Lalu, MM; Panas, D; Schulz, R; Schulze, C; Wildhirt, SM | 1 |
| Chen, CP; Kitani, K; Park, JC; Rhyu, DY; Tanaka, T; Yokozawa, T | 1 |
| Bryner, KD; Christie, I; Ganser, G; Hobbs, GR; Hoeldtke, RD; McNeill, DR; Riggs, JE; Van Dyke, K; Warehime, SS | 1 |
| Hayase, F; Hayashi, MC; Horiuchi, S; Kinae, N; Masuda, S; Nagai, R; Unno, Y | 1 |
| Hoffman, S; Kalyanaraman, B; Kotamraju, S; Newman, DK; Newman, PJ; Wakim, B; Zhao, T | 1 |
| Klotz, LO; Schroeder, P; Sies, H | 1 |
| Ikeda, M; Ito, T; Suzuki, M; Tabuchi, M; Tomita, I; Tomita, T; Umegaki, K | 1 |
| Ikeda, M; Suzuki, M; Tabuchi, M; Tomita, T | 1 |
| Aquaro, S; Cufari, A; Iannone, M; Mollace, V; Muscoli, C; Palma, E; Paolino, D; Perno, CF; Rotiroti, D; Salvemini, D | 1 |
| Kang, BH; Lin, YS; Su, WF; Wang, HW | 1 |
| Choi, JJ; Kim, HC; Kim, WK; Ko, KH; Kong, MY; Lee, SJ | 1 |
| Kaiser, WM; Leydecker, MT; Morot-Gaudry, JF; Morot-Gaudry-Talarmain, Y; Moureaux, T; Quilleré, I; Rockel, P | 1 |
| Hataishi, R; Hirano, S; Jones, RC; Kobayashi, H; Takahashi, Y; Zapol, WM | 1 |
| Choi, JS; Chung, HY; Kim, AR; Kim, JE; Zou, Y | 1 |
| Arendt, T; Lüth, HJ; Münch, G | 1 |
| Frisbee, JC; Maier, KG; Stepp, DW | 1 |
| Farhood, A; Ho, YS; Jaeschke, H; Knight, TR | 1 |
| Barbera, A; Caputi, AP; Centorrino, T; Chatterjee, PK; Ciccolo, A; Cuzzocrea, S; Dugo, L; Fulia, F; Mazzon, E; McDonald, MC; Serraino, I; Thiemermann, C | 1 |
| Beckman, JS; Parks, DA; Teng, RJ; Ye, YZ | 1 |
| Bates, TE; Bella, R; Calabrese, V; Foresti, R; Giuffrida Stella, AM; Pennisi, G; Ravagna, A; Scapagnini, G | 1 |
| Herold, S; Mehl, M; Shivashankar, K | 1 |
| Bigelow, DJ; Galeva, NA; Knyushko, TV; Schöneich, C; Sharov, VS; Williams, TD | 1 |
| Brimer, CM; Hooper, DC; Kean, RB; Koprowski, H; Mikheeva, T; Scott, GS; Spitsin, SV; Zborek, A | 1 |
| Betancor-Fernandez, A; Polidori, MC; Sies, H; Stahl, W | 1 |
| Li, PL; Zhang, DX; Zou, AP | 1 |
| Cassina, A; Castro, L; Hodara, R; Quijano, C; Radi, R | 1 |
| Augusto, O; Denicola, A; Linares, E; Lopes de Menezes, S; Radi, R; Romero, N | 1 |
| Crapo, JD; Demchenko, IT; Oury, TD; Piantadosi, CA | 1 |
| Chai, Q; Gutterman, DD; Kleinman, LH; Li, H; Liu, Y; Terata, K | 1 |
| Drapier, JC; Soum, E | 1 |
| Mayer, B; Pfeiffer, S | 1 |
| Bennett, BM; Ji, Y | 1 |
| Persson, K; Poljakovic, M | 1 |
| Bao, F; DeWitt, DS; Liu, D; Prough, DS | 1 |
| Bauer, JA; Mihm, MJ | 1 |
| Kamatani, T; Osaki, T; Ueta, E; Yamamoto, T | 1 |
| Bhargava, K; Feix, J; Hogg, N; Joseph, J; Kalyanaraman, B; Keszler, A; Zhang, H | 1 |
| Akaike, M; Azuma, H; Iuchi, T; Matsumoto, T; Mitsui, T; Ohshima, Y; Shintani, Y | 1 |
| Arsic, M; Bachschmid, M; Balan, A; Daiber, A; Przybylski, M; Schmidt, P; Ullrich, V; Youhnovski, N | 1 |
| Deckman, G; Harfouche, R; Hussain, SN; Kebbewar, M; Rallis, G; Vassilakopoulos, T | 1 |
| Adewuya, O; Bian, K; Irie, Y; Murad, F; Onigu-Otite, E | 1 |
| Hollenberg, PF; Kent, UM; Lin, HL; Waskell, L; Zhang, H | 1 |
| Looft, J; Ong, CN; Pickenhagen, W; Rose, P; Whiteman, M; Widder, S | 1 |
| Choa, EJ; Park, JC; Rhyu, DY; Yokozawa, T | 1 |
| Clements, MK; Hanson, AJ; Nelson-Overton, LK; Quinn, MT; Rohn, TT; Siemsen, DW; Swain, SD | 1 |
| Denicola, A; Radi, R; Thomson, L | 1 |
| Ainola, M; Haralambous, S; Hukkanen, M; Kollias, G; Konttinen, YT; Platts, LA; Polak, JM | 1 |
| Bosca, L; Camarero, J; Colado, MI; Green, AR; O'Shea, E; Sanchez, V; Zeini, M | 1 |
| Amici, M; Angeletti, M; Eleuteri, AM; Fioretti, E; Lupidi, G | 1 |
| Bai, J; Hashimoto, N; Hattori, I; Kondo, N; Nakamura, H; Nozaki, K; Takagi, Y; Yodoi, J | 1 |
| Arteel, GE; Conzelmann, LO; Lehnert, M; Lemasters, JJ; Smutney, OM; Thurman, RG; Zhong, Z | 1 |
| Bartlett, RK; Galeva, NA; Smallwood, HS; Squier, TC; Urbauer, JL; Urbauer, RJ; Williams, TD | 1 |
| Guruvadoo, LK; Kocis, JM; Kuo, WN | 1 |
| Borges, CR; Kuhn, DM; Watson, JT | 1 |
| Irie, Y; Kamisaki, Y; Martin, E; Murad, F; Saeki, M | 1 |
| He, J; Kamei, H; Mizuno, M; Nabeshima, T; Nakajima, A; Tran, MH; Yamada, K | 1 |
| Abou-Mohamed, G; Behzadian, MA; Caldwell, RB; Caldwell, RW; El-Remessy, AB; Franklin, T | 1 |
| Maccaglia, A; Mallozzi, C; Minetti, M | 1 |
| Cuzzocrea, S; Ischiropoulos, H; Salvemini, D | 1 |
| Geddes, TJ; Javitch, JA; Kuhn, DM; Park, S | 1 |
| Dong, Y; Endo, T; Iguchi, F; Ito, J; Kim, TS; Lee, JE; Lee, SH; Naito, Y; Nakagawa, T; Yuki, K | 1 |
| Birnboim, HC; Goldstein, R; Robertson, S; Sandhu, JK | 1 |
| Butterfield, DA; Castegna, A; Klein, JB; Lynn, B; Markesbery, WR; Thongboonkerd, V | 1 |
| Aoyagi, K; Cho, EJ; Rhyu, DY; Yokozawa, T | 1 |
| Csonka, C; Ferdinandy, P; Giricz, Z; Onody, A | 1 |
| Huang, XL; Jin, GH; Yi, YL; Zhang, JL; Zhou, JL | 1 |
| Kishimoto, C; Shioji, K; Yuan, Z | 1 |
| Bauer, JA; Mihm, MJ; Reiser, PJ; Yu, F | 1 |
| Farivar, AS; Fraga, C; Groves, JT; Mulligan, MS; Naidu, BV; Salzman, AL; Szabo, C; Woolley, SM | 1 |
| Busija, DW; Hortobágyi, T; Horváth, EM; Komjáti, K; Lacza, Z; Szabó, C | 1 |
| Capaldi, RA; Ghosh, SS; Murray, J; Taylor, SW; Zhang, B | 1 |
| Barillari, G; Ceriello, A; Da Ros, R; Gasparini, D; Quagliaro, L | 1 |
| Fraga, C; Mulligan, MS; Naidu, BV; Salzman, AL; Szabo, C; Verrier, ED | 1 |
| Grossi, L | 1 |
| Carrier, M; Desjardins, F; Malo, O; Perrault, LP; Tanguay, JF; Tardif, JC | 1 |
| Augusto, O; Denicola, A; Detweiler, CD; Linares, E; Mason, RP; Radi, R; Romero, N | 1 |
| Alvarez, B; Barnes, S; Carballal, S; Freeman, BA; Kirk, MC; Radi, R | 1 |
| Brookes, PS; Darley-Usmar, VM | 1 |
| Esposito, K; Giugliano, D; Marfella, R | 1 |
| Devaraj, S; Jialal, I; Venugopal, SK | 1 |
| Didik, J; Gebicka, L | 1 |
| Lee, JH; Park, JW; Yang, ES | 1 |
| Auker, CR; Chavko, M; McCarron, RM | 1 |
| Andrews, L; Bagnasco, P; Greendorfer, JS; MacMillan-Crow, LA; Thompson, JA; Young, CJ | 1 |
| Alterman, MA; Kanski, J; Schöneich, C | 1 |
| Morgan, DL; Shines, CJ | 1 |
| Andrekopoulos, C; Joseph, J; Kalivendi, S; Kalyanaraman, B; Zhang, H | 1 |
| Marino, G; Minetti, M; Pietraforte, D; Salzano, AM | 1 |
| Bezerra, MM; Brain, SD; da Rocha, FA; de Melo, LB; Greenacre, S; Jerônimo, SM; Keeble, J | 1 |
| Sharma, SS; Thiyagarajan, M | 1 |
| Görg, B; Häussinger, D; Höngen, A; Reinehr, R | 1 |
| Qu, LN; Yang, B; Yang, TB; Yuan, YH; Zhao, H; Zhong, P | 1 |
| Fukuyama, N; Hayashi, Y; Matsuda, H; Miyamoto, Y; Nakazawa, H; Sawa, Y; Takahashi, T | 1 |
| Bast, A; Haenen, GR; Rezk, BM; van der Vijgh, WJ | 1 |
| Arima, H; Furukawa, K; Ikota, N; Kinoshita, T; Nakagawa, H; Ozawa, T; Takusagawa, M | 1 |
| Hiramoto, K; Kikugawa, K; Ohkawa, T | 1 |
| Fattori, B; Gesi, M; Giambelluca, MA; Giannessi, F; Paparelli, A; Rocchi, V; Ruffoli, R; Scavuzzo, MC; Ursino, F | 1 |
| Grosclaude, J; Guermonprez, L; Morot-Gaudry-Talarmain, Y; Rezaei, H; Treguer, E | 1 |
| Krueger, RC | 1 |
| Anesetti, G; Barbeito, L; Beckman, JS; Cassina, P; Castellanos, R; Martinez-Palma, L; Pehar, M; Peluffo, H | 1 |
| Deen, WM; Wang, C | 1 |
| Aruga, T; Dohi, K; Ikeda, Y; Inn, R; Ohtaki, H; Shioda, HS | 1 |
| Hinson, JA; Jaeschke, H; James, LP; Knight, TR; McCullough, SS | 1 |
| Fisher, MT; Khor, HK; Schöneich, C | 1 |
| Grisham, MB; Tarpey, MM; Wink, DA | 1 |
| Augusto, O; Chen, CL; Chen, W; Chen, YR; Mason, RP; Radi, R; Zweier, JL | 1 |
| Li, Q; Ling, YL; Zhou, JL; Zhu, XG | 1 |
| Herold, S | 1 |
| Detloff, MR; Hall, ED; Johnson, K; Kupina, NC | 1 |
| Hennig, B; Saraswathi, V; Toborek, M; Wu, G | 1 |
| Adcock, IM; Barnes, PJ; Hanazawa, T; Ito, K; Tomita, K | 1 |
| Gorren, AC; Mayer, B; Rehn, M; Schmidt, K; Wippel, R | 1 |
| Haginaka, J; Kagota, S; Kunitomo, M; Matsuno, S; Yamaguchi, Y | 1 |
| Radi, R | 3 |
| Hsiung, MW; Kang, BH; Wang, HW | 1 |
| Aizenman, E; He, K; Pal, S | 1 |
| Almeida, A; Bolanos, JP; García-Nogales, P | 1 |
| Buettner, GR; Clark, CB; Davies, LR; Kerber, RE; Kregel, KC; Martin, SM; Miller, FJ; Xu, L; Zhang, Y | 1 |
| Can, A; Dalkara, T; Gürsoy-Ozdemir, Y | 1 |
| Bachschmid, M; Beckman, JS; Daiber, A; Munzel, T; Ullrich, V | 1 |
| Geddes, TJ; Kuhn, DM; Sadidi, M; Sakowski, SA | 1 |
| Akamine, EH; Carvalho, MH; de Britto, LR; Fortes, ZB; Franco, Mdo C; Kawamoto, EM; Muscara, MN; Nigro, D; Scavone, C; Teixeira, SA; Tostes, RC | 1 |
| Foster, N; Görg, B; Häussinger, D; Reinehr, R; Schliess, F | 1 |
| Herold, S; Kalinga, S; Matsui, T; Watanabe, Y | 1 |
| Halliwell, B; Jenner, A; Peng, ZF; Tang, SY; Whiteman, M; Yong, EL | 1 |
| Brouwers, JF; Drummen, GP; Gadella, BM; Post, JA | 1 |
| Chopin, C; Depontieu, F; Lancel, S; Marechal, X; Mordon, S; Neviere, R; Scherpereel, A; Tissier, S | 1 |
| Kaul, CL; Sharma, SS; Thiyagarajan, M | 1 |
| Gutiérrez-Martín, Y; Gutiérrez-Merino, C; Henao, F; Iñesta-Vaquera, FA; Martín-Romero, FJ | 1 |
| Balasubramanian, D; Chalasani, M; Lakshmanan, J; Thiagarajan, G | 1 |
| Kolodziejczyk, J; Nowak, P; Olas, B; Wachowicz, B | 1 |
| Chae, C; Cho, WS | 1 |
| Eaton, S; Fukumoto, K; Pierro, A; Spitz, L; Zammit, VA | 1 |
| Choi, JB; Igarashi, Y; Kashiwagi, A; Kawamori, R; Maegawa, H; Mineki, R; Murayama, K; Nomiyama, T; Ogihara, T; Taka, H; Tanaka, Y; Uchida, T; Uchino, H; Watada, H | 1 |
| Autore, G; Britti, D; Cuzzocrea, S; Di Paola, R; Genovese, T; Marzocco, S; Pinto, A; Scollo, G; Sorrentino, R | 1 |
| Armstrong, JS; Cheung, NS; Chu, SH; Halliwell, B; Jia-Ling, S; Moore, PK; Whiteman, M; Wong, BS | 1 |
| Bouton, C; Drapier, JC; Gonzalez, D | 1 |
| Atsuta, I; Kido, MA; Masuda, KF; Nishijima, K; Tanaka, T; Yamaza, T | 1 |
| Deretic, V; Master, S; Rusnak, F; Timmins, GS | 1 |
| Crow, JP; Mogal, A; Nielsen, VG; Parks, DA; Zhou, F | 1 |
| Borutaite, V; Brown, GC | 1 |
| Baldwin, WM; Bao, C; Fox-Talbot, K; Lowenstein, CJ; Matsushita, K; Ohnishi, T; Padalko, E; Sun, H | 1 |
| Bergt, C; Brunzell, J; Byun, J; Chait, A; Geary, RL; Green, PS; Heinecke, JW; Kassim, SY; McDonald, TO; O'brien, K; Oram, JF; Pennathur, S; Shao, B; Singh, P | 1 |
| Fukuyama, N; Hayashi, Y; Ichikawa, H; Matsuda, H; Nakazawa, H; Nishimura, M; Ohtake, S; Sawa, Y | 1 |
| Dikalov, S; Greilberger, J; Oettl, K; Reibnegger, G | 1 |
| Dekhuijzen, PN; Ennen, L; Heunks, LM; van der Heijden, HF; van Kuppevelt, TH; Versteeg, EM; Vina, J; Zhu, X | 1 |
| Darvesh, AS; Gudelsky, GA; Yamamoto, BK | 1 |
| Chirino, YI; Hernández-Pando, R; Pedraza-Chaverrí, J | 1 |
| Cinel, I; Cinel, L; Ercan, B; Kanik, A; Koksel, O; Oral, U; Ozdulger, A; Tamer, L | 1 |
| Choi, JS; Chung, HY; Jung, HA; Kim, CH; Kim, DH; Lee, JW; Park, TH | 1 |
| Ali, SF; Barrera, D; Galván-Arzate, S; Pedraza-Chaverrí, J; Pérez-de La Cruz, V; Rembao, D; Salinas-Lara, C; Santamaría, A; Santiago-López, D; Vázquez-Román, B | 1 |
| Ambrósio, AF; Araújo, IM; Carvalho, CM; Verdasca, MJ | 1 |
| Barley, RD; Lam, EW; Peters, E; Pollock, S; Shallow, MC | 1 |
| Bergt, C; Fu, X; Green, P; Heinecke, JW; Oda, MN; Oram, JF; Shao, B; Voss, JC | 1 |
| Alves, MJ; Augusto, O; Fernandes, DC; Medinas, DB | 1 |
| Abatan, OI; Charniauskaya, T; Groves, JT; Mabley, JG; Obrosova, IG; Szabó, C; Zsengellér, Z | 1 |
| Bartoli, M; Caldwell, RB; el-Remessy, AB; Fulton, D; Platt, DH | 1 |
| Chan, JY; Chan, SH; Chang, AY; Cheng, HL; Li, FC; Tsai, CY | 1 |
| Ahmed, S; Anderson, NR; Elfatih, A; Gama, R; Holland, MR; Horton, R; Mansoor, S | 1 |
| Floridi, A; Galli, F; Lannone, A; Pagliarani, S; Piroddi, M; Tomasi, A | 1 |
| Giner, RM; Máñez, S; Olmos, A; Recio, Mdel C; Ríos, JL | 1 |
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| Ahmad, R; Ahsan, H; Hussain, A | 1 |
| Hu, RK; Huang, CC; Ren, QL; Tan, Y; Wang, FH; Xia, GC; Yan, SH; Yao, Q; Zhao, J; Zhao, NW; Zhou, G | 1 |
| Urmey, AR; Zondlo, NJ | 1 |
| Dasgupta, S; Hati, S; Panda, A; Roy, P | 1 |
| Cao, W; Gao, Y; Lei, Y; Song, M; Sun, X | 1 |
| Ahsan, H; Akram, MF; Alam, K; Khan, MA; Rizvi, MA | 1 |
| Baumgart-Vogt, E; Bednorz, M; Brandes, RP; Buchmann, G; Dorfmüller, P; Eichstaedt, C; Fysikopoulos, A; Gattenlöhner, S; Geiszt, M; Ghofrani, HA; Gredic, M; Grimminger, F; Grünig, E; Günther, A; Hadzic, S; Hecker, A; Hecker, M; Henneke, I; Hinderhofer, K; Jaksch, P; Kanbagli, ZI; Karnati, S; Klepetko, W; Knoepp, F; Kojonazarov, B; Kraut, S; Müller, N; Padberg, W; Pak, O; Parajuli, N; Pichl, A; Rezende, F; Scheibe, S; Schermuly, RT; Schröder, K; Seeger, W; Seimetz, M; Sommer, N; Veith, C; Vogelmeier, CF; Weissmann, N; Wilhelm, J; Wittig, I; Wu, CY | 1 |
| Kobayashi, T; Li, S; Liu, J; Wang, L; Yang, B; Yu, B | 1 |
| Choromańska, B; Choromańska, K; Dadan, J; Maciejczyk, M; Myśliwiec, H; Myśliwiec, P; Wojskowicz, P; Zalewska, A; Łuba, M | 1 |
| Bruno, G; Lackmann, JW; Lalk, M; von Woedtke, T; Wende, K; Wenske, S | 1 |
| Batthyány, C; Demicheli, V; Lima, A; Radi, R; Sastre, S; Tomasina, F; Tórtora, V; Zeida, A | 1 |
| Chong, SJF; Goh, BC; Kong, LR; Pervaiz, S; Yee, YH | 1 |
| Eckhardt, A; Kohutiar, M | 1 |
| Kosmachevskaya, OV; Nasybullina, EI; Novikova, NN; Shumaev, KB; Topunov, AF | 1 |
| Cai, JR; Du, Y; Hu, SQ; Liu, YQ; Wang, Y; Wu, CJ; Wu, XQ | 1 |
| Baseggio Conrado, A; Bigioni, I; Fontana, M; Francioso, A; Maina, S; Mariano, A; Mosca, L; Scotto d'Abusco, A | 1 |
| Cai, Z; Dong, N; Feng, J; Hui, H; Li, F; Liu, F; Liu, M; Liu, Z; Rao, Z; Shang, Y; Wang, Y; Xu, L; Yuan, Z | 1 |
| Jiang, M; Jiang, ZS; Wang, GX; Zhang, DW; Zhao, XM | 1 |
| Bartesaghi, S; Folkes, LK; Radi, R; Trujillo, M; Wardman, P | 1 |
| Carrillo, R; García-Rodríguez, R; Lahoz, F; Pérez-Márquez, LA; Perretti, MD | 1 |
| Arasimowicz-Jelonek, M; Floryszak-Wieczorek, J; Jagodzik, P; Mattoo, A; Polcyn, W; Płóciennik, A; Sobieszczuk-Nowicka, E | 1 |
| Brajshori, N; Feigl, G; Greilberger, J; Herwig, R; Kacar, M; Stiegler, P; Wintersteiger, R | 1 |
| Ai, H; Dulin, H; Gao, L; Hai, R; Hendricks, N; Wuang, K; Xu, D | 1 |
| Esteban-Gómez, D; Pazos, E; Sánchez-Fernández, R; Sánchez-Temprano, A | 1 |
| Ihara, H; Kasamatsu, S; Komae, S; Matsukura, K | 1 |
35 review(s) available for peroxynitrous acid and tyrosine
| Article | Year |
|---|---|
Nitric oxide: a pro-inflammatory mediator in lung disease?
Topics: Animals; Humans; Inflammation Mediators; Lung; Lung Diseases; Nitrates; Nitric Oxide; Peroxynitrous Acid; Respiratory System; Signal Transduction; Tyrosine | 2000 |
Protein oxidation in aging and age-related diseases.
Topics: Aging; Amino Acids; Animals; Antioxidants; Apoptosis; Cross-Linking Reagents; Cysteine; Disease; Humans; Longevity; Methionine; Models, Biological; Nitric Oxide; Oxidants; Oxidation-Reduction; Oxidative Stress; Peptides; Peroxynitrous Acid; Protein Denaturation; Proteins; Rats; Reactive Oxygen Species; Tyrosine | 2001 |
Nitrogen dioxide and carbonate radical anion: two emerging radicals in biology.
Topics: Carbonates; Free Radicals; Nitrogen Dioxide; Oxidation-Reduction; Peroxynitrous Acid; Reactive Oxygen Species; Tyrosine | 2002 |
The nitration of proteins in platelets: significance in platelet function.
Topics: Animals; Blood Platelets; Humans; Hydrogen-Ion Concentration; Models, Biological; Nitrogen; Peroxynitrous Acid; Reactive Nitrogen Species; Reactive Oxygen Species; Signal Transduction; Time Factors; Tyrosine | 2002 |
Peroxynitrite signaling: receptor tyrosine kinases and activation of stress-responsive pathways.
Topics: Animals; Dose-Response Relationship, Drug; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Models, Biological; Models, Chemical; Nitrogen; Oxidative Stress; Oxygen; Peroxynitrous Acid; Protein-Tyrosine Kinases; Reactive Nitrogen Species; Reactive Oxygen Species; Signal Transduction; Transcription, Genetic; Tyrosine | 2002 |
Peroxynitrite reactions and formation in mitochondria.
Topics: Animals; Cell Death; Cell Line; Diffusion; Electron Transport; Free Radicals; Humans; Mice; Mitochondria; Models, Biological; Models, Chemical; Nitric Oxide; Nitrogen Dioxide; Peroxynitrous Acid; Rats; Tumor Cells, Cultured; Tyrosine | 2002 |
Roles of nitric oxide and superoxide in inflammation.
Topics: 2-Naphthylamine; Animals; Arginine; Blotting, Western; Capillary Permeability; Chemotaxis, Leukocyte; Citrulline; Fluorescent Dyes; Fluorometry; Inflammation; Nitrates; Nitric Oxide; Nitrites; Oxidation-Reduction; Oxidative Stress; Peroxynitrous Acid; Rats; Superoxides; Tyrosine | 2003 |
Peroxynitrite-dependent modifications of tyrosine residues in hemoglobin. Formation of tyrosyl radical(s) and 3-nitrotyrosine.
Topics: Animals; Carbon Dioxide; Catalysis; Ferric Compounds; Free Radicals; Hemoglobins; Humans; Oxidation-Reduction; Peroxynitrous Acid; Tyrosine | 2003 |
Methods for detection of reactive metabolites of oxygen and nitrogen: in vitro and in vivo considerations.
Topics: Algorithms; Animals; Humans; Hydrogen Peroxide; Nitric Oxide; Oxidants; Oxidative Stress; Peroxynitrous Acid; Reactive Nitrogen Species; Reactive Oxygen Species; S-Nitrosothiols; Superoxides; Tyrosine | 2004 |
Nitrosative stress and potassium channel-mediated neuronal apoptosis: is zinc the link?
Topics: Animals; Apoptosis; Humans; Neurons; Oxidative Stress; Peroxynitrous Acid; Potassium Channels, Voltage-Gated; Tyrosine; Zinc | 2004 |
Provoking neuroprotection by peroxynitrite.
Topics: Animals; Cell Death; Cell Survival; Cytoprotection; Glutathione; Humans; Neurons; Peroxynitrous Acid; Receptor Protein-Tyrosine Kinases; Signal Transduction; Sulfhydryl Compounds; Tyrosine; Up-Regulation | 2004 |
Nitrotyrosine as a marker for peroxynitrite-induced neurotoxicity: the beginning or the end of the end of dopamine neurons?
Topics: Animals; Biomarkers; Biopterins; Dopamine; Humans; Neurons; Peroxynitrous Acid; Quinones; Tyrosine | 2004 |
Inhibition of mitochondrial respiratory complex I by nitric oxide, peroxynitrite and S-nitrosothiols.
Topics: Adenosine Triphosphate; Animals; Electron Transport Complex I; Humans; Iron-Sulfur Proteins; Macrophages; Mitochondria; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrosation; Nitroso Compounds; Parkinson Disease; Peroxynitrous Acid; Reactive Nitrogen Species; Tyrosine | 2004 |
Role of nitrosative stress and peroxynitrite in the pathogenesis of diabetic complications. Emerging new therapeutical strategies.
Topics: Animals; Cardiomyopathies; Diabetes Complications; Diabetic Angiopathies; Diabetic Nephropathies; Diabetic Neuropathies; Diabetic Retinopathy; Endothelium, Vascular; Humans; Nitric Oxide; Oxidative Stress; Peroxynitrous Acid; Poly(ADP-ribose) Polymerases; Superoxides; Tyrosine | 2005 |
Drugs modulating the biological effects of peroxynitrite and related nitrogen species.
Topics: Animals; Antioxidants; DNA Damage; Free Radical Scavengers; Humans; Nitric Oxide; Peroxynitrous Acid; Reactive Nitrogen Species; Reactive Oxygen Species; Tyrosine | 2007 |
Oxidative alterations of cyclooxygenase during atherogenesis.
Topics: Animals; Arachidonic Acid; Atherosclerosis; Cyclooxygenase Inhibitors; Cysteine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Activation; Heme; Humans; Intramolecular Oxidoreductases; MAP Kinase Signaling System; Nitric Oxide; Nitrogen Oxides; Oxidation-Reduction; Peroxynitrous Acid; Prostaglandin-Endoperoxide Synthases; Tyrosine | 2006 |
Red blood cells in the metabolism of nitric oxide-derived peroxynitrite.
Topics: Blood Vessels; Erythrocytes; Humans; Molecular Structure; Nitric Oxide; Oxidants; Peroxynitrous Acid; Signal Transduction; Superoxides; Tyrosine | 2006 |
Peroxynitrite and protein tyrosine nitration of prostacyclin synthase.
Topics: Animals; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diabetes Complications; Humans; Intramolecular Oxidoreductases; Oxidation-Reduction; Peroxynitrous Acid; Tyrosine | 2007 |
The chemistry of peroxynitrite: implications for biological activity.
Topics: Free Radicals; Models, Chemical; Nitrosation; Peroxynitrous Acid; Solutions; Tyrosine; Water | 2008 |
Detection and characterization of peroxynitrite-induced modifications of tyrosine, tryptophan, and methionine residues by tandem mass spectrometry.
Topics: Animals; Humans; Methionine; Oligopeptides; Peroxynitrous Acid; Tandem Mass Spectrometry; Tryptophan; Tyrosine | 2008 |
Protein tyrosine nitration: selectivity, physicochemical and biological consequences, denitration, and proteomics methods for the identification of tyrosine-nitrated proteins.
Topics: Animals; Humans; Mass Spectrometry; Mitochondria; Models, Chemical; Nitrogen; Peroxynitrous Acid; Phenol; Protein Processing, Post-Translational; Proteins; Proteomics; Spectrophotometry; Subcellular Fractions; Tetranitromethane; Tyrosine | 2009 |
Understanding the fate of peroxynitrite in plant cells--from physiology to pathophysiology.
Topics: Nitrates; Nitric Oxide; Oxidants; Peroxynitrous Acid; Plants; Reactive Oxygen Species; Superoxides; Tyrosine | 2011 |
Mathematical and computational models of oxidative and nitrosative stress.
Topics: Cardiovascular Diseases; Computer Simulation; Diabetes Mellitus; Humans; Hypertension; Kinetics; Microcirculation; Models, Biological; Nitric Oxide; Oxidative Stress; Peroxynitrous Acid; Superoxide Dismutase; Superoxides; Tyrosine | 2011 |
The good and bad effects of cysteine S-nitrosylation and tyrosine nitration upon insulin exocytosis: a balancing act.
Topics: Apoptosis; Cyclic GMP; Cysteine; Diabetes Mellitus; Exocytosis; Female; Humans; Insulin-Secreting Cells; Male; Nitric Oxide; Oxidation-Reduction; Peroxynitrous Acid; Protein Processing, Post-Translational; Signal Transduction; Tyrosine | 2012 |
Effects of stress on endocrine and metabolic processes and redirection: cross talk between subcellular compartments.
Topics: Animals; Animals, Domestic; Endocrine System; Immunity; Lipid Bilayers; Metabolism; Nitric Oxide; Oxidative Stress; Peroxynitrous Acid; Subcellular Fractions; Superoxides; Tyrosine | 2012 |
Peroxynitrite, a stealthy biological oxidant.
Topics: Animals; Humans; Hydrogen-Ion Concentration; Mitochondria; Nitric Oxide; Nitrogen; Oxidants; Oxidation-Reduction; Peroxynitrous Acid; Superoxide Dismutase; Superoxides; Tyrosine | 2013 |
Tyrosine nitration as mediator of cell death.
Topics: Animals; Cell Death; HSP90 Heat-Shock Proteins; Humans; Inflammation; Peroxynitrous Acid; Reactive Nitrogen Species; Signal Transduction; Superoxide Dismutase; Tyrosine | 2014 |
Metal-catalyzed protein tyrosine nitration in biological systems.
Topics: Animals; Humans; Hydrogen Peroxide; Ions; Metals; Nitric Oxide; Nitrites; Nitrogen; Oxidation-Reduction; Oxidative Stress; Peroxynitrous Acid; Proteins; Reactive Nitrogen Species; Reactive Oxygen Species; Superoxides; Tyrosine | 2014 |
Biochemistry of Peroxynitrite and Protein Tyrosine Nitration.
Topics: Carbon Dioxide; Coenzymes; Electron Transport Complex IV; Heme; Iron-Sulfur Proteins; Kinetics; Peroxidases; Peroxynitrous Acid; Proteins; Tyrosine | 2018 |
S-Nitrosylation in Regulation of Inflammation and Cell Damage.
Topics: Gene Expression Regulation; Guanylate Cyclase; Humans; Inflammation; Lipids; NF-kappa B; Nitric Oxide; Peroxynitrous Acid; Protein Processing, Post-Translational; Receptors, G-Protein-Coupled; Signal Transduction; Superoxides; Tyrosine | 2018 |
Human Mn-superoxide dismutase inactivation by peroxynitrite: a paradigm of metal-catalyzed tyrosine nitration in vitro and in vivo.
Topics: Catalysis; Humans; Metals; Models, Molecular; Nitric Oxide; Peroxynitrous Acid; Superoxide Dismutase; Tyrosine | 2018 |
Oxygen radicals, nitric oxide, and peroxynitrite: Redox pathways in molecular medicine.
Topics: Animals; Biomedical Research; Free Radicals; Humans; Molecular Medicine; Nitric Oxide; Oxidation-Reduction; Peroxynitrous Acid; Proteins; Superoxide Dismutase; Tyrosine | 2018 |
Peroxynitrite: cellular pathology and implications in autoimmunity.
Topics: Antigen-Antibody Reactions; Antigens; Autoantibodies; Autoimmunity; Biomarkers; DNA; DNA Breaks; Humans; Peroxynitrous Acid; Tyrosine | 2019 |
Protein tyrosine nitration in atherosclerotic endothelial dysfunction.
Topics: Atherosclerosis; Humans; Nitric Oxide; Peroxynitrous Acid; Proteins; Tyrosine | 2022 |
Radiolysis Studies of Oxidation and Nitration of Tyrosine and Some Other Biological Targets by Peroxynitrite-Derived Radicals.
Topics: Free Radicals; Hydroxyl Radical; Oxidation-Reduction; Peroxynitrous Acid; Tyrosine | 2022 |
4 trial(s) available for peroxynitrous acid and tyrosine
| Article | Year |
|---|---|
Nitric oxide synthase is present in the cerebrospinal fluid of patients with active multiple sclerosis and is associated with increases in cerebrospinal fluid protein nitrotyrosine and S-nitrosothiols and with changes in glutathione levels.
Topics: Adult; Blotting, Western; Catalase; Cerebrospinal Fluid Proteins; Female; Glutathione; Glutathione Disulfide; Humans; Male; Middle Aged; Multiple Sclerosis; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Peroxynitrous Acid; Recurrence; Reference Values; S-Nitrosothiols; Tyrosine | 2002 |
Glucocorticoid excess induces superoxide production in vascular endothelial cells and elicits vascular endothelial dysfunction.
Topics: Adolescent; Adult; Aged; Antioxidants; Autoimmune Diseases; Cells, Cultured; Dexamethasone; Electron Transport; Endothelium, Vascular; Enzyme Inhibitors; Female; Forearm; Glucocorticoids; Humans; Hydrogen Peroxide; Male; Middle Aged; Muscle, Skeletal; NADH, NADPH Oxidoreductases; NADPH Oxidases; Nitric Oxide; Nitric Oxide Donors; Peroxynitrous Acid; Reactive Oxygen Species; Regional Blood Flow; Superoxides; Tyrosine; Vasodilation; Xanthine Oxidase | 2003 |
Leukocyte-depleted terminal blood cardioplegia provides superior myocardial protective effects in association with myocardium-derived nitric oxide and peroxynitrite production for patients undergoing prolonged aortic crossclamping for more than 120 minute
Topics: Adolescent; Adult; Aged; Aorta; Aortic Valve; Blood; Cardioplegic Solutions; Constriction; Female; Heart Arrest, Induced; Humans; Inflammation Mediators; Leukapheresis; Leukocyte Elastase; Male; Middle Aged; Myocardial Reperfusion Injury; Myocardium; Neutrophils; Nitric Oxide; Peroxynitrous Acid; Tyrosine | 2003 |
Effects of Alpha Lipoic Acid on Multiple Cytokines and Biomarkers and Recurrence of Atrial Fibrillation Within 1 Year of Catheter Ablation.
Topics: Aged; Antioxidants; Atrial Fibrillation; Biomarkers; Blood Glucose; C-Reactive Protein; Catheter Ablation; Cholesterol, HDL; Cholesterol, LDL; Cytokines; Double-Blind Method; Female; Humans; Interleukin-10; Interleukin-6; Interleukin-8; Male; Middle Aged; Natriuretic Peptide, Brain; Peptide Fragments; Peroxynitrous Acid; Postoperative Care; Recurrence; Thioctic Acid; Treatment Outcome; Triglycerides; Tumor Necrosis Factor-alpha; Tyrosine | 2017 |
633 other study(ies) available for peroxynitrous acid and tyrosine
| Article | Year |
|---|---|
Effect of beta-carotene on the transformation of tyrosine by nitrogen dioxide and peroxynitrous acid.
Topics: Ascorbic Acid; beta Carotene; Dioxanes; Dose-Response Relationship, Drug; Free Radical Scavengers; Nitrogen Dioxide; Nitrous Acid; Peroxynitrous Acid; Time Factors; Tyrosine; Vitamin E | 1999 |
The nitration of platelet cytosolic proteins during agonist-induced activation of platelets.
Topics: Aspirin; Blood Platelets; Blood Proteins; Blotting, Western; Cell Adhesion Molecules; Collagen; Cyclooxygenase Inhibitors; Cytosol; Enzyme-Linked Immunosorbent Assay; Humans; Membrane Proteins; Microfilament Proteins; Molecular Weight; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide Synthase; Nitrous Acid; Oxidants; Peroxynitrous Acid; Phosphoproteins; Platelet Activation; Thrombin; Tyrosine | 2000 |
Prevention of dopaminergic neurotoxicity by targeting nitric oxide and peroxynitrite: implications for the prevention of methamphetamine-induced neurotoxic damage.
Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Chromatography, High Pressure Liquid; Corpus Striatum; Cyclic N-Oxides; Disease Models, Animal; Dopamine; Dopamine Uptake Inhibitors; Drug Administration Schedule; Drug Interactions; Electrochemistry; Free Radical Scavengers; Homovanillic Acid; Imidazoles; Indazoles; Male; Methamphetamine; Mice; Mice, Inbred C57BL; Models, Biological; Neuroprotective Agents; Neurotoxicity Syndromes; Nitric Oxide; Peroxynitrous Acid; Tyrosine | 2000 |
Oxidative post-translational modifications of alpha-synuclein in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; alpha-Synuclein; Animals; beta-Synuclein; Cell Line; Corpus Striatum; Disease Models, Animal; Humans; Kidney; Male; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Oxidation-Reduction; Parkinsonian Disorders; Peroxynitrous Acid; Precipitin Tests; Protein Processing, Post-Translational; Synaptophysin; Synucleins; Transfection; Tyrosine | 2001 |
In vitro production of peroxynitrite by haemocytes from marine bivalves: C-ELISA determination of 3-nitrotyrosine level in plasma proteins from Mytilus galloprovincialis and Crassostrea gigas.
Topics: Animals; Antibodies, Monoclonal; Bivalvia; Blood Proteins; Enzyme-Linked Immunosorbent Assay; Hemocytes; Ostreidae; Peroxynitrous Acid; Phagocytosis; Reference Standards; Tyrosine | 2001 |
Role of peroxynitrite in macrophage microbicidal mechanisms in vivo revealed by protein nitration and hydroxylation.
Topics: Animals; Carbon Dioxide; Carbonates; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Electron Spin Resonance Spectroscopy; Free Radicals; Hydroxylation; Leishmania infantum; Leishmaniasis; Macrophage Activation; Macrophages; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Microscopy, Confocal; Microscopy, Fluorescence; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxidase; Peroxynitrous Acid; Tyrosine | 2001 |
Protein oxidation and proteolysis by the nonradical oxidants singlet oxygen or peroxynitrite.
Topics: Acetylcysteine; Animals; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Ferritins; Free Radicals; Hydrogen Peroxide; Liver; Multienzyme Complexes; Naphthols; Nitric Oxide; Oxidation-Reduction; Peroxynitrous Acid; Proteasome Endopeptidase Complex; Proteins; Rats; Singlet Oxygen; Tyrosine | 2001 |
Effects of chronic N-acetylcysteine treatment on the actions of peroxynitrite on aortic vascular reactivity in hypertensive rats.
Topics: Acetylcholine; Acetylcysteine; Animals; Aorta; Drug Synergism; Free Radical Scavengers; Glutathione; Glutathione Disulfide; Hypertension; In Vitro Techniques; Isoproterenol; Male; Malondialdehyde; Nitrates; Nitroprusside; Peroxynitrous Acid; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Time Factors; Tyrosine; Vasodilation; Vasodilator Agents; Vasomotor System | 2001 |
Modulation of reactive oxygen species in endothelial cells by peroxynitrite-treated lipoproteins.
Topics: Arteriosclerosis; Catalase; Cell Survival; Cells, Cultured; Chromatography, High Pressure Liquid; Electron Spin Resonance Spectroscopy; Endothelium, Vascular; Free Radical Scavengers; Humans; Lipoproteins; Lipoproteins, HDL; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase; Peroxynitrous Acid; Prostaglandin-Endoperoxide Synthases; Reactive Oxygen Species; Superoxide Dismutase; Tyrosine | 2001 |
EPR detection of glutathionyl and protein-tyrosyl radicals during the interaction of peroxynitrite with macrophages (J774).
Topics: Animals; Benzenesulfonates; Cell Survival; Cells, Cultured; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Free Radicals; Glutathione; Macrophages; Mice; Models, Chemical; Nitroso Compounds; Peroxynitrous Acid; Proteins; Spin Labels; Sulfhydryl Compounds; Tyrosine | 2001 |
Inhibition of peroxynitrite-induced nitration of tyrosine by glutathione in the presence of carbon dioxide through both radical repair and peroxynitrate formation.
Topics: Antioxidants; Carbon Dioxide; Free Radicals; Glutathione; Peroxynitrous Acid; Superoxides; Tyrosine | 2001 |
The central nervous system inflammatory response to neurotropic virus infection is peroxynitrite dependent.
Topics: Acute Disease; Animals; Antigens, Viral; Blood-Brain Barrier; Borna Disease; Borna disease virus; Brain; Brain Chemistry; Chemotaxis, Leukocyte; Encephalitis, Viral; Female; Free Radical Scavengers; Free Radicals; Gene Expression Profiling; Immunocompetence; Inflammation; Lymphocyte Count; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidation-Reduction; Peroxynitrous Acid; Polymerase Chain Reaction; Rats; Rats, Inbred Lew; T-Lymphocyte Subsets; Tyrosine; Uric Acid; Virus Replication | 2001 |
Nitric oxide inhibits mitochondrial NADH:ubiquinone reductase activity through peroxynitrite formation.
Topics: Animals; Brain; Electron Transport; Electron Transport Complex I; Electron Transport Complex II; Female; Heart; Hydrogen Peroxide; Immunoblotting; Liver; Mitochondria; Mitochondria, Heart; Multienzyme Complexes; NAD; NADH, NADPH Oxidoreductases; Nitric Oxide; Oxidoreductases; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Succinate Cytochrome c Oxidoreductase; Succinate Dehydrogenase; Succinates; Superoxide Dismutase; Superoxides; Tyrosine | 2001 |
Tyrosine nitration in human spermatozoa: a physiological function of peroxynitrite, the reaction product of nitric oxide and superoxide.
Topics: Calcimycin; Female; Follicular Fluid; Humans; Ionophores; Male; Nitric Oxide; Peroxynitrous Acid; Phosphorylation; Proteins; Sperm Capacitation; Sperm Motility; Spermatozoa; Superoxides; Tyrosine | 2001 |
Acidic fibroblast growth factor signaling inhibits peroxynitrite-induced death of osteoblasts and osteoblast precursors.
Topics: Animals; Cell Division; Cell Line; Cell Survival; Fibroblast Growth Factor 1; Mice; Nitrates; Osteoblasts; Osteocalcin; Osteopontin; Peroxynitrous Acid; Rats; Sialoglycoproteins; Signal Transduction; Stem Cells; Tyrosine | 2001 |
Oxidative and nitrosative stress in acute renal ischemia.
Topics: Animals; Azoles; Blotting, Western; Cell Line; Cyclic N-Oxides; DNA Damage; Enzyme Inhibitors; Free Radical Scavengers; Immunohistochemistry; Ischemia; Isoindoles; Kidney; Lipid Peroxidation; Lysine; Macrophages; Male; Mice; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Organoselenium Compounds; Oxidative Stress; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Spin Labels; Superoxide Dismutase; Tyrosine | 2001 |
Evidence for peroxynitrite-mediated modifications to p53 in human gliomas: possible functional consequences.
Topics: Blotting, Western; Electrophoresis, Polyacrylamide Gel; Glioblastoma; Glioma; Humans; Immunohistochemistry; Oligonucleotides; Peroxynitrous Acid; Protein Processing, Post-Translational; Recombinant Proteins; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Tyrosine | 2001 |
Inactivation of glutathione S-transferases by nitric oxide-derived oxidants: exploring a role for tyrosine nitration.
Topics: Animals; Chromatography, Affinity; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Glutathione Transferase; Hydrogen Peroxide; Liver; Male; Mice; Nitrates; Nitric Oxide; Oxidants; Peptide Fragments; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Reducing Agents; S-Nitrosoglutathione; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tyrosine | 2001 |
A novel selectin blocker alleviates oxidative stress of lung reperfusion injury.
Topics: Animals; Deoxyguanosine; Free Radical Scavengers; Ischemia; Lung; Male; Neutrophil Infiltration; Oxidative Stress; Peroxynitrous Acid; Pulmonary Circulation; Rats; Rats, Inbred Lew; Reactive Oxygen Species; Reperfusion Injury; Selectins; Tyrosine | 2001 |
SIN-1-induced cytotoxicity in mixed cortical cell culture: peroxynitrite-dependent and -independent induction of excitotoxic cell death.
Topics: Animals; Astrocytes; Catalase; Cell Death; Cells, Cultured; Cerebral Cortex; Free Radical Scavengers; Mice; Molsidomine; Neurons; Neurotoxins; Peroxynitrous Acid; Superoxide Dismutase; Tyrosine | 2001 |
Protein tyrosine nitration in mouse peritoneal macrophages activated in vitro and in vivo: evidence against an essential role of peroxynitrite.
Topics: Animals; Female; Free Radical Scavengers; Hydrogen Peroxide; Interferon-gamma; Lipopolysaccharides; Macrophage Activation; Macrophages, Peritoneal; Male; Metalloporphyrins; Mice; Mice, Inbred C57BL; Nitrates; Nitric Oxide; Nitrites; Peroxidase; Peroxynitrous Acid; Propionibacterium acnes; Proteins; Superoxides; Thioglycolates; Time Factors; Tyrosine | 2001 |
Augmented oxidative stress of platelets in chronic smokers. Mechanisms of impaired platelet-derived nitric oxide bioactivity and augmented platelet aggregability.
Topics: Administration, Oral; Adult; Antioxidants; Ascorbic Acid; Biological Availability; Blood Platelets; Case-Control Studies; Chronic Disease; Cyclic GMP; Free Radical Scavengers; Glutathione; Humans; Male; Nitric Oxide; Oxidation-Reduction; Oxidative Stress; Peroxynitrous Acid; Platelet Aggregation; Smoking; Time Factors; Tyrosine | 2001 |
Crystal structure of the antioxidant enzyme glutathione reductase inactivated by peroxynitrite.
Topics: Animals; Antioxidants; Binding Sites; Catalysis; Crystallography, X-Ray; Disulfides; Dose-Response Relationship, Drug; Flavins; Glutathione Reductase; Humans; Hydrogen-Ion Concentration; Kinetics; Models, Molecular; Nitrogen; Peptides; Peroxynitrous Acid; Plasmodium falciparum; Protein Binding; Signal Transduction; Spectrophotometry; Toluene; Tyrosine | 2002 |
Peroxynitrite is an essential component of cytokines production mechanism in human monocytes through modulation of nuclear factor-kappa B DNA binding activity.
Topics: Base Sequence; Cytokines; DNA; DNA Primers; Dose-Response Relationship, Drug; Humans; Monocytes; NF-kappa B; Peroxynitrous Acid; Protein Binding; Transcription, Genetic; Tyrosine | 2002 |
Mechanism of peroxynitrite interaction with ferric hemoglobin and identification of nitrated tyrosine residues. CO(2) inhibits heme-catalyzed scavenging and isomerization.
Topics: Carbon Dioxide; Carboxyhemoglobin; Electron Spin Resonance Spectroscopy; Ferric Compounds; Free Radical Scavengers; Heme; Humans; In Vitro Techniques; Isomerism; Methemoglobin; Peroxynitrous Acid; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry; Spin Labels; Tyrosine | 2001 |
Peroxynitrite-induced nitration of tyrosine-34 does not inhibit Escherichia coli iron superoxide dismutase.
Topics: Amino Acid Sequence; Escherichia coli; Isoenzymes; Kinetics; Molecular Sequence Data; Peptide Fragments; Peroxynitrous Acid; Protein Conformation; Spectrometry, Mass, Electrospray Ionization; Superoxide Dismutase; Tyrosine | 2001 |
Expression of inducible nitric oxide synthase and nitrotyrosine in borderline leprosy lesions.
Topics: Biopsy; Humans; Immunoenzyme Techniques; Leprosy, Borderline; Leprosy, Tuberculoid; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Skin; Tyrosine | 2001 |
(-)-Epicatechin inhibits nitration and dimerization of tyrosine in hydrophilic as well as hydrophobic environments.
Topics: Antioxidants; Catechin; Dimerization; In Vitro Techniques; Liposomes; Nitrates; Peroxynitrous Acid; Reactive Oxygen Species; Tyrosine | 2001 |
Peroxynitrite is a mediator of cytokine-induced destruction of human pancreatic islet beta cells.
Topics: Cell Death; Cytokines; Drug Combinations; Guanidines; Humans; Immunohistochemistry; In Vitro Techniques; Interferon-gamma; Interleukin-1; Islets of Langerhans; Peroxynitrous Acid; Tumor Necrosis Factor-alpha; Tyrosine | 2001 |
Dehydroepiandrosterone inhibits the death of immunostimulated rat C6 glioma cells deprived of glucose.
Topics: Adjuvants, Immunologic; Animals; Astrocytes; Brain; Brain Ischemia; Cell Death; Cytokines; Dehydroepiandrosterone; Enzyme Inhibitors; Free Radical Scavengers; Glioma; Glucose; Herbicides; Humans; Interferon-gamma; Lipopolysaccharides; Metalloporphyrins; Molsidomine; Neurons; Nitric Oxide; Oxidative Stress; Paraquat; Peroxynitrous Acid; Superoxide Dismutase; Tumor Cells, Cultured; Tyrosine | 2001 |
Mitochondrial tyrosine nitration precedes chronic allograft nephropathy.
Topics: Animals; Chronic Disease; Cytochrome c Group; Graft Rejection; Kidney Transplantation; Mitochondria; Models, Animal; Peroxynitrous Acid; Rats; Reactive Nitrogen Species; Renal Insufficiency; Superoxide Dismutase; Transplantation, Homologous; Tyrosine | 2001 |
Synaptosomal plasma membrane Ca(2+) pump activity inhibition by repetitive micromolar ONOO(-) pulses.
Topics: Animals; Brain; Calcium; Calcium-Transporting ATPases; Cell Membrane; Enzyme Stability; Homeostasis; Peroxynitrous Acid; Rats; Rats, Wistar; Synaptosomes; Tyrosine | 2002 |
High glucose via peroxynitrite causes tyrosine nitration and inactivation of prostacyclin synthase that is associated with thromboxane/prostaglandin H(2) receptor-mediated apoptosis and adhesion molecule expression in cultured human aortic endothelial cel
Topics: Aorta; Apoptosis; Cell Adhesion Molecules; Cells, Cultured; Cyclic GMP; DNA Fragmentation; Endothelium, Vascular; Glucose; Humans; Nitrates; Peroxynitrous Acid; Prostaglandin-Endoperoxide Synthases; Receptors, Prostaglandin; Receptors, Thromboxane A2, Prostaglandin H2; Superoxides; Tyrosine | 2002 |
Selective nitration of mitochondrial complex I by peroxynitrite: involvement in mitochondria dysfunction and cell death of dopaminergic SH-SY5Y cells.
Topics: Adenosine Triphosphate; Apoptosis; Cell Death; Cysteine Proteinase Inhibitors; Dopamine; Electron Transport Complex I; Humans; Mitochondria; Molsidomine; NADH, NADPH Oxidoreductases; Nitric Oxide Donors; Oligopeptides; Peroxynitrous Acid; Subcellular Fractions; Tumor Cells, Cultured; Tyrosine | 2002 |
Effects of oxygen and glucose deprivation on the expression and distribution of neuronal and inducible nitric oxide synthases and on protein nitration in rat cerebral cortex.
Topics: Animals; Blotting, Western; Brain Ischemia; Calcium; Cerebral Cortex; Disease Models, Animal; Enzyme Inhibitors; Gene Expression; Glucose; Hypoxia; Immunohistochemistry; Magnetic Resonance Imaging; Male; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Peroxynitrous Acid; Rats; Rats, Wistar; Reperfusion Injury; Tyrosine | 2002 |
The reaction of nitric oxide with 6-hydroxydopamine: implications for Parkinson's disease.
Topics: alpha-Synuclein; Animals; Cattle; Nerve Tissue Proteins; Nitric Oxide; Oxidation-Reduction; Oxidopamine; Parkinson Disease; Parkinson Disease, Secondary; Peroxynitrous Acid; Serum Albumin, Bovine; Superoxide Dismutase; Synucleins; Tyrosine | 2002 |
The effects of peroxynitrite on erythrocytes.
Topics: Alleles; Animals; Chromatography, High Pressure Liquid; Enzyme Induction; Erythrocytes; Escherichia coli; Escherichia coli Infections; Glutathione Peroxidase; Oxidative Stress; Peroxynitrous Acid; Rats; Sodium-Potassium-Exchanging ATPase; Spectrophotometry; Tyrosine | 2001 |
Deficiency of myeloperoxidase increases infarct volume and nitrotyrosine formation in mouse brain.
Topics: Animals; Brain; Brain Infarction; Female; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Peroxidase; Peroxynitrous Acid; Reperfusion Injury; Time Factors; Tyrosine | 2002 |
Protein denitration/modification by Escherichia coli nitrate reductase and mammalian cytochrome P-450 reductase.
Topics: Animals; Escherichia coli; Histones; Models, Chemical; NADP; NADPH-Ferrihemoprotein Reductase; Nitrate Reductase; Nitrate Reductases; Nitrates; Peroxynitrous Acid; Tyrosine | 2002 |
The role of protein nitration in the inhibition of platelet activation by peroxynitrite.
Topics: Blood Platelets; Cyclic GMP; Dose-Response Relationship, Drug; Humans; Nitrates; Nitric Oxide; Peroxynitrous Acid; Phosphorylation; Platelet Activation; Platelet Aggregation; Proteins; Signal Transduction; Thrombin; Time Factors; Tyrosine | 2002 |
Peroxynitrite-induced nitration of tyrosine hydroxylase: identification of tyrosines 423, 428, and 432 as sites of modification by matrix-assisted laser desorption ionization time-of-flight mass spectrometry and tyrosine-scanning mutagenesis.
Topics: Catalysis; Dopamine; Electrophoresis, Polyacrylamide Gel; Humans; Mutagenesis, Site-Directed; Mutation; Nitrogen; Peroxynitrous Acid; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tyrosine; Tyrosine 3-Monooxygenase | 2002 |
Participation of peroxynitrite in oxidative modification of LDL by aqueous extracts of cigarette smoke.
Topics: Animals; Apolipoproteins B; Chelating Agents; Free Radical Scavengers; Lipoproteins, LDL; Male; Peroxynitrous Acid; Rabbits; Reactive Oxygen Species; Tobacco Smoke Pollution; Tyrosine | 2002 |
Intra-luminal exposure of murine airways to peroxynitrite causes inflammation but not hyperresponsiveness.
Topics: Acetylcholine; Animals; Bronchi; Bronchial Hyperreactivity; Inflammation; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Molsidomine; Peroxynitrous Acid; Trachea; Tyrosine | 2002 |
Inhibitory effect of isoflavones on peroxynitrite-mediated low-density lipoprotein oxidation.
Topics: Genistein; Humans; Isoflavones; Lipoproteins, LDL; Nitrates; Oxidants; Oxidation-Reduction; Peroxynitrous Acid; Tyrosine | 2002 |
Evidence that peroxynitrite affects human osteoblast proliferation and differentiation.
Topics: Alkaline Phosphatase; Catalase; Cell Differentiation; Cell Division; Cells, Cultured; Humans; Interferon-gamma; Interleukin-1; Molsidomine; Nitric Oxide Donors; Nitrites; Osteoblasts; Peroxynitrous Acid; Recombinant Proteins; Superoxide Dismutase; Thymidine; Tumor Necrosis Factor-alpha; Tyrosine | 2002 |
Deficiency in inducible nitric oxide synthase protects mice from ozone-induced lung inflammation and tissue injury.
Topics: Administration, Inhalation; Animals; Bronchoalveolar Lavage Fluid; Cells, Cultured; Dinoprostone; Female; Interferon-gamma; Lipopolysaccharides; Lung; Macrophages, Alveolar; Mice; Mice, Inbred Strains; Mice, Knockout; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidants, Photochemical; Ozone; Peroxynitrous Acid; Pneumonia; Superoxides; Tyrosine | 2002 |
Diabetes-induced nitrative stress in the retina, and correction by aminoguanidine.
Topics: Animals; Cattle; Cells, Cultured; Cyclic GMP; Diabetes Complications; Diabetes Mellitus; Diabetic Retinopathy; Endothelium, Vascular; Glucose; Guanidines; Hyperglycemia; Immunohistochemistry; Male; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidative Stress; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Retina; Streptozocin; Tyrosine | 2002 |
Prevention of peroxynitrite-dependent damage by carnosine and related sulphonamido pseudodipeptides.
Topics: alpha 1-Antitrypsin; Anserine; Antioxidants; Carnosine; Chromatography, High Pressure Liquid; Electrophoresis, Agar Gel; Enzyme Activation; Humans; Lipoproteins, LDL; Oxidation-Reduction; Peroxynitrous Acid; Tyrosine | 2002 |
Peroxynitrite mediated linoleic acid oxidation and tyrosine nitration in the presence of synthetic neuromelanins.
Topics: Aldehydes; Chromatography, High Pressure Liquid; Cross-Linking Reagents; Dose-Response Relationship, Drug; Hydrogen Peroxide; Linoleic Acid; Melanins; Nitrogen; Oxygen; Peroxynitrous Acid; Tyrosine | 2000 |
Whence nitrotyrosine?
Topics: Animals; Humans; Oxidative Stress; Peroxynitrous Acid; Reactive Nitrogen Species; Tyrosine | 2002 |
Inducible nitric oxide synthase-deficient mice exhibit resistance to the acute pancreatitis induced by cerulein.
Topics: Amylases; Animals; Ceruletide; DNA-Binding Proteins; I-kappa B Proteins; Intercellular Adhesion Molecule-1; Lipase; Lipid Peroxidation; Male; Mice; Mice, Inbred Strains; Mice, Mutant Strains; Mortality; Neutrophil Infiltration; NF-KappaB Inhibitor alpha; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; P-Selectin; Pancreatitis; Peroxynitrous Acid; Poly(ADP-ribose) Polymerases; Tyrosine | 2002 |
Tyrosine 125 of alpha-synuclein plays a critical role for dimerization following nitrative stress.
Topics: alpha-Synuclein; Dimerization; DNA, Complementary; Electrophoresis, Polyacrylamide Gel; Humans; Immunoblotting; In Vitro Techniques; Microscopy, Confocal; Nerve Tissue Proteins; Nitrates; Oxidative Stress; Peroxynitrous Acid; Synucleins; Tyrosine | 2002 |
Differential modulation of host macrophage function by AK-5 tumor is dependent on the site of tumor transplantation.
Topics: Animals; Antigens, Neoplasm; Coculture Techniques; Cytokines; Macrophages; Neoplasm Transplantation; Neoplasms, Experimental; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Rats; Rats, Wistar; Reactive Oxygen Species; Tumor Cells, Cultured; Tyrosine | 2002 |
Nitration of cytoskeletal proteins in the chicken embryo chorioallantoic membrane.
Topics: Actins; Allantois; Animals; Blotting, Western; Chick Embryo; Chorion; Cytoskeletal Proteins; Eosinophil Peroxidase; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxidases; Peroxynitrous Acid; Tissue Extracts; Tubulin; Tyrosine; X-Rays | 2002 |
Anesthetic preconditioning: triggering role of reactive oxygen and nitrogen species in isolated hearts.
Topics: Anesthetics; Animals; Coronary Circulation; Enzyme Inhibitors; Guinea Pigs; Heart; In Vitro Techniques; Ischemic Preconditioning, Myocardial; Methyl Ethers; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Peroxynitrous Acid; Reactive Oxygen Species; Reperfusion Injury; Sevoflurane; Time Factors; Tyrosine | 2002 |
A reassessment of the peroxynitrite scavenging activity of uric acid.
Topics: alpha 1-Antitrypsin; Antioxidants; Ascorbic Acid; Benzothiazoles; Bicarbonates; Chromans; Coloring Agents; Glutathione; Guanine; Humans; Indicators and Reagents; Peroxynitrous Acid; Pyrogallol; Reactive Nitrogen Species; Serine Proteinase Inhibitors; Sulfonic Acids; Tyrosine; Uric Acid | 2002 |
Nitration/S-nitrosation of proteins by peroxynitrite-treatment and subsequent modification by glutathione S-transferase and glutathione peroxidase.
Topics: Animals; Blotting, Western; Cattle; Cysteine; Electrophoresis, Polyacrylamide Gel; Glutathione; Glutathione Peroxidase; Glutathione Transferase; Hemoglobins; Histones; Horses; In Vitro Techniques; Mice; Nitrosation; Oxidative Stress; Peroxynitrous Acid; S-Nitrosothiols; Tyrosine | 2002 |
Cytotoxicity by nitrite inhalants is not related to peroxynitrite formation.
Topics: Administration, Inhalation; Animals; Blotting, Western; Cell Survival; Cells, Cultured; Hydrogen Peroxide; Macrophages; Mice; Mitochondria; Nitrites; Oxidants; Oxygen Consumption; Peroxynitrous Acid; Tyrosine | 2002 |
Nitric oxide in the development of obliterative bronchiolitis in a heterotopic pig model.
Topics: Animals; Bronchi; Bronchiolitis Obliterans; Cell Division; Disease Models, Animal; Fibroblasts; Lung Transplantation; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Respiratory Mucosa; Superoxide Dismutase; Swine; Tyrosine | 2002 |
Protein tyrosine nitration and peroxynitrite.
Topics: Animals; Cytochrome c Group; Mice; Nitric Oxide; Peroxynitrous Acid; Proteins; Superoxides; Tyrosine | 2002 |
Protein nitration is predominantly mediated by a peroxynitrite-dependent pathway in cultured human leucocytes.
Topics: Aniline Compounds; Cells, Cultured; Extracellular Space; Humans; Leukocytes; Metalloporphyrins; Nitrates; Peroxidase; Peroxynitrous Acid; Proteins; Spermine; Tetradecanoylphorbol Acetate; Tyrosine | 2002 |
Methamphetamine-induced dopaminergic neurotoxicity and production of peroxynitrite are potentiated in nerve growth factor differentiated pheochromocytoma 12 cells.
Topics: Animals; Cell Differentiation; Dopamine; Dose-Response Relationship, Drug; Drug Synergism; Kinetics; Methamphetamine; Nerve Growth Factor; Neurotoxins; PC12 Cells; Peroxynitrous Acid; Pheochromocytoma; Rats; Time Factors; Tyrosine | 2002 |
Impaired nitric oxide-mediated flow-induced coronary dilation in hyperhomocysteinemia: morphological and functional evidence for increased peroxynitrite formation.
Topics: Animals; Blotting, Western; Coronary Circulation; Coronary Vessels; Enzyme Inhibitors; Hyperhomocysteinemia; Immunohistochemistry; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Peroxynitrous Acid; Rats; Rats, Wistar; Superoxides; Tyrosine; Vasodilation | 2002 |
Expression of inducible and endothelial nitric oxide synthases, formation of peroxynitrite and reactive oxygen species in human chronic renal transplant failure.
Topics: Adult; Female; Graft Rejection; Humans; Immunohistochemistry; Kidney Failure, Chronic; Kidney Transplantation; Male; Middle Aged; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Peroxynitrous Acid; Reactive Oxygen Species; Transplantation, Homologous; Tyrosine | 2002 |
Peroxynitrite affects exocytosis and SNARE complex formation and induces tyrosine nitration of synaptic proteins.
Topics: Animals; Brain Chemistry; Dose-Response Relationship, Drug; Exocytosis; Fluorescent Dyes; Glutamic Acid; Macromolecular Substances; Male; Membrane Proteins; Munc18 Proteins; Nerve Tissue Proteins; Peroxynitrous Acid; Proteins; Rats; Rats, Sprague-Dawley; SNARE Proteins; Sodium Bicarbonate; Sodium Dodecyl Sulfate; Synaptosomal-Associated Protein 25; Synaptosomes; Tyrosine; Vesicular Transport Proteins | 2002 |
Detection of peroxynitrite-induced protein and DNA modifications.
Topics: Animals; Blood Proteins; Blotting, Western; DNA; Electrophoresis, Polyacrylamide Gel; Humans; Immunohistochemistry; Indicators and Reagents; Nitric Oxide; Peroxynitrous Acid; Proteins; Reactive Oxygen Species; Spectrophotometry; Superoxides; Tyrosine | 2002 |
Enhanced NO and superoxide generation in dysfunctional hearts from endotoxemic rats.
Topics: Animals; Endotoxemia; Heart Diseases; Hydrogen Peroxide; Lipopolysaccharides; Male; Myocardial Contraction; Myocardium; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Oxygen Consumption; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Sepsis; Superoxides; Tyrosine; Xanthine Oxidase | 2002 |
Potential of sanguiin H-6 against oxidative damage in renal mitochondria and apoptosis mediated by peroxynitrite in vivo.
Topics: Animals; Blood Urea Nitrogen; Caspase 3; Caspases; Creatinine; Disease Models, Animal; DNA Fragmentation; Hydrolyzable Tannins; Ischemia; Kidney; Kidney Diseases; Lipopolysaccharides; Male; Mitochondria; Oxidative Stress; Peroxynitrous Acid; Rats; Rats, Wistar; Sanguisorba; Tannins; Tyrosine | 2002 |
Nitrosative stress, uric Acid, and peripheral nerve function in early type 1 diabetes.
Topics: Adolescent; Adult; Autonomic Nervous System; Child; Diabetes Mellitus, Type 1; Dinoprost; F2-Isoprostanes; Female; Heart Conduction System; Humans; Male; Motor Neurons; Neural Conduction; Nitrates; Nitrites; Peripheral Nerves; Peroxynitrous Acid; Reference Values; Sweating; Time Factors; Tyrosine; Uric Acid | 2002 |
Peroxynitrite induces formation of N( epsilon )-(carboxymethyl) lysine by the cleavage of Amadori product and generation of glucosone and glyoxal from glucose: novel pathways for protein modification by peroxynitrite.
Topics: 2-Naphthylamine; Aldehydes; Animals; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Glucose; Glyoxal; Guanidines; Ketoses; Lysine; Mice; Mice, Inbred BALB C; Peroxynitrous Acid; Serum Albumin; Tyrosine | 2002 |
Nitration of PECAM-1 ITIM tyrosines abrogates phosphorylation and SHP-2 binding.
Topics: Amino Acid Sequence; Cell Line; Humans; Intracellular Signaling Peptides and Proteins; Jurkat Cells; Molecular Sequence Data; Peroxynitrous Acid; Phosphorylation; Phosphotyrosine; Platelet Endothelial Cell Adhesion Molecule-1; Protein Binding; Protein Structure, Tertiary; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatases; Receptors, Immunologic; Tyrosine | 2002 |
Fluctuation of serum NO(x) concentration at stroke onset in a rat spontaneous stroke model (M-SHRSP). Peroxynitrite formation in brain lesions.
Topics: Animals; Brain; Immunohistochemistry; Magnetic Resonance Imaging; Male; Nitric Oxide; Peroxynitrous Acid; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Stroke; Tyrosine | 2002 |
Concurrent formation of peroxynitrite with the expression of inducible nitric oxide synthase in the brain during middle cerebral artery occlusion and reperfusion in rats.
Topics: Animals; Cerebral Cortex; Cerebral Infarction; Cerebrovascular Circulation; Chemotaxis, Leukocyte; Disease Models, Animal; Hypoxia-Ischemia, Brain; Infarction, Middle Cerebral Artery; Male; Neutrophils; Nitric Oxide; Nitric Oxide Synthase; Peroxidase; Peroxynitrous Acid; Rats; Rats, Wistar; Reaction Time; Reperfusion Injury; Tyrosine | 2002 |
Peroxynitrite decomposition catalyst prevents apoptotic cell death in a human astrocytoma cell line incubated with supernatants of HIV-infected macrophages.
Topics: Apoptosis; Astrocytes; Astrocytoma; Catalysis; Culture Media, Conditioned; Ferric Compounds; Flow Cytometry; HIV Infections; HIV-1; Humans; Macrophages; Malondialdehyde; Metalloporphyrins; Peroxynitrous Acid; Tumor Cells, Cultured; Tyrosine | 2002 |
Immunolocalization of inducible nitric oxide synthase and 3-nitrotyrosine in recurrently inflamed, human palatine tonsils.
Topics: Humans; Immunohistochemistry; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Palatine Tonsil; Peroxynitrous Acid; Recurrence; Tonsillitis; Tyrosine | 2002 |
Ciclopirox prevents peroxynitrite toxicity in astrocytes by maintaining their mitochondrial function: a novel mechanism for cytoprotection by ciclopirox.
Topics: Adenosine Triphosphate; Animals; Astrocytes; Cell Cycle; Cell Death; Cells, Cultured; Ciclopirox; Flow Cytometry; Glutathione; Hydrogen Peroxide; Hydroxyl Radical; L-Lactate Dehydrogenase; Membrane Potentials; Mitochondria; Molsidomine; Neuroprotective Agents; Nitric Oxide; Oxidation-Reduction; Peroxynitrous Acid; Pyridones; Rats; Rats, Sprague-Dawley; Rhodamines; Serum Albumin, Bovine; Superoxides; Tyrosine | 2002 |
Nitrite accumulation and nitric oxide emission in relation to cellular signaling in nitrite reductase antisense tobacco.
Topics: 14-3-3 Proteins; Antisense Elements (Genetics); Carbon Dioxide; Cyclophilins; Ferredoxin-Nitrite Reductase; Light; Nicotiana; Nitrate Reductase (NADH); Nitrate Reductases; Nitric Oxide; Nitrite Reductases; Nitrites; Peroxynitrous Acid; Plants, Genetically Modified; Signal Transduction; Tyrosine; Tyrosine 3-Monooxygenase | 2002 |
Myeloperoxidase-associated tyrosine nitration after intratracheal administration of lipopolysaccharide in rats.
Topics: Administration, Inhalation; Alkylating Agents; Animals; Antibody Specificity; Bronchoalveolar Lavage Fluid; Bronchodilator Agents; Cyclophosphamide; Immunohistochemistry; Leukocyte Count; Lipopolysaccharides; Lung; Male; Neutropenia; Neutrophils; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxidase; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Tyrosine | 2002 |
Peroxynitrite scavenging activity of sinapic acid (3,5-dimethoxy-4-hydroxycinnamic acid) isolated from Brassica juncea.
Topics: Brassica; Coumaric Acids; Free Radical Scavengers; Lipid Peroxidation; Lipoproteins, LDL; Molsidomine; Nitrates; Nitric Oxide; Oxidation-Reduction; Peroxynitrous Acid; Serum Albumin, Bovine; Superoxides; Tyrosine | 2002 |
Aberrant expression of NOS isoforms in Alzheimer's disease is structurally related to nitrotyrosine formation.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Biomarkers; Brain; Female; Humans; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Peroxynitrous Acid; Pyramidal Cells; Tyrosine | 2002 |
Oxidant stress-induced increase in myogenic activation of skeletal muscle resistance arteries in obese Zucker rats.
Topics: Animals; Arteries; Blood Pressure; Catalase; Endothelium, Vascular; Fatty Acids, Unsaturated; In Vitro Techniques; Male; Muscle, Skeletal; Obesity; Oxidative Stress; Peroxynitrous Acid; Polyethylene Glycols; Potassium Channel Blockers; Potassium Channels, Calcium-Activated; Rats; Rats, Zucker; Superoxide Dismutase; Tyrosine; Vascular Patency; Vascular Resistance; Vasoconstriction; Vasomotor System | 2002 |
Peroxynitrite is a critical mediator of acetaminophen hepatotoxicity in murine livers: protection by glutathione.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Antidotes; Chemical and Drug Induced Liver Injury; Glutathione; Immunohistochemistry; Injections, Intravenous; Liver; Male; Mice; Mice, Inbred C3H; Mitochondria, Liver; Necrosis; Peroxynitrous Acid; Serum Albumin, Bovine; Tyrosine | 2002 |
Effects of calpain inhibitor I on multiple organ failure induced by zymosan in the rat.
Topics: Animals; Calpain; Cell Movement; Cyclooxygenase 2; Dose-Response Relationship, Drug; Glycoproteins; Immunohistochemistry; Intestinal Mucosa; Intestines; Isoenzymes; Liver; Lung; Male; Malondialdehyde; Multiple Organ Failure; Neutrophils; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peritoneum; Peritonitis; Peroxidase; Peroxynitrous Acid; Poly Adenosine Diphosphate Ribose; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Tyrosine; Zymosan | 2002 |
Urate produced during hypoxia protects heart proteins from peroxynitrite-mediated protein nitration.
Topics: Animals; Ascorbic Acid; Brain; Heart; Hypoxanthine; Hypoxia; In Vitro Techniques; Myocardium; Nitric Oxide; Nitrosation; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Tyrosine; Urate Oxidase; Uric Acid; Xanthine Dehydrogenase; Xanthine Oxidase | 2002 |
Myoglobin scavenges peroxynitrite without being significantly nitrated.
Topics: Animals; Apoproteins; Free Radical Scavengers; Globins; Immunohistochemistry; Metmyoglobin; Myoglobin; Nitrates; Oxyhemoglobins; Peroxynitrous Acid; Tryptophan; Tyrosine | 2002 |
Two-dimensional separation of the membrane protein sarcoplasmic reticulum Ca-ATPase for high-performance liquid chromatography-tandem mass spectrometry analysis of posttranslational protein modifications.
Topics: Amino Acid Sequence; Animals; Calcium-Transporting ATPases; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Hydrolysis; In Vitro Techniques; Molecular Sequence Data; Muscle, Skeletal; Peptide Mapping; Peroxynitrous Acid; Protein Processing, Post-Translational; Rabbits; Sarcoplasmic Reticulum; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Trypsin; Tyrosine | 2002 |
Comparison of uric acid and ascorbic acid in protection against EAE.
Topics: Albumins; Animals; Antioxidants; Ascorbic Acid; Blood-Brain Barrier; Cell Line; Encephalomyelitis, Autoimmune, Experimental; Free Radicals; Immunohistochemistry; Iron; Lipid Peroxidation; Mice; Molsidomine; Myelin Sheath; Nitric Oxide; Oxygen; Peroxynitrous Acid; Rhodamines; Time Factors; Tyrosine; Uric Acid | 2002 |
In vitro antioxidant activity of 2,5,7,8-tetramethyl-2-(2'-carboxyethyl)-6-hydroxychroman (alpha-CEHC), a vitamin E metabolite.
Topics: Antioxidants; Ascorbic Acid; Chromans; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Models, Chemical; Nitrogen; Oxygen; Peroxynitrous Acid; Propionates; Spectrometry, Fluorescence; Time Factors; Tyrosine; Vitamin E | 2002 |
Ceramide-induced activation of NADPH oxidase and endothelial dysfunction in small coronary arteries.
Topics: Animals; Biological Transport; Cattle; Cells, Cultured; Ceramides; Coronary Vessels; Endothelium, Vascular; Enzyme Activation; Isoenzymes; NADPH Oxidases; Peroxynitrous Acid; Phosphoproteins; Reactive Oxygen Species; Tyrosine | 2003 |
EPR detection of glutathiyl and hemoglobin-cysteinyl radicals during the interaction of peroxynitrite with human erythrocytes.
Topics: Cyclic N-Oxides; Cysteine; Electron Spin Resonance Spectroscopy; Erythrocytes; Free Radicals; Glutathione; Hemoglobins; Humans; Oxidants; Oxidation-Reduction; Peroxynitrous Acid; Spin Labels; Tyrosine | 2002 |
Regulation of the brain's vascular responses to oxygen.
Topics: Animals; Blood Flow Velocity; Blood Pressure; Brain; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Humans; Hyperbaric Oxygenation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microdialysis; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Oxygen; Peroxynitrous Acid; Superoxide Dismutase; Superoxide Dismutase-1; Superoxides; Tyrosine; Vasomotor System | 2002 |
Peroxynitrite inhibits Ca2+-activated K+ channel activity in smooth muscle of human coronary arterioles.
Topics: Animals; Arterioles; Coronary Vessels; Female; Humans; Immunohistochemistry; In Vitro Techniques; Male; Membrane Potentials; Microscopy, Video; Middle Aged; Muscle, Smooth, Vascular; Patch-Clamp Techniques; Peptides; Peroxynitrous Acid; Potassium; Potassium Channel Blockers; Potassium Channels, Calcium-Activated; Rats; Rats, Sprague-Dawley; Tyrosine; Vasodilation; Vasodilator Agents | 2002 |
Nitric oxide and peroxynitrite promote complete disruption of the [4Fe-4S] cluster of recombinant human iron regulatory protein 1.
Topics: Aconitate Hydratase; Blotting, Western; Conserved Sequence; Electrophoretic Mobility Shift Assay; Ferrozine; Humans; Iron Regulatory Protein 1; Iron-Sulfur Proteins; Mercaptoethanol; Molsidomine; Nitrates; Nitric Oxide; Peroxynitrous Acid; Recombinant Proteins; Superoxide Dismutase; Tyrosine | 2003 |
Protein tyrosine nitration and peroxynitrite: reply.
Topics: Animals; Kinetics; Macrophages; Nitric Oxide; Peroxynitrous Acid; Proteins; Superoxides; Tyrosine | 2002 |
Activation of microsomal glutathione s-transferase by peroxynitrite.
Topics: Animals; Cysteine; Enzyme Activation; Glutathione Transferase; Hydrogen Peroxide; Imidazoles; Male; Microsomes, Liver; Nitrates; Peptide Fragments; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Tetranitromethane; Tyrosine | 2003 |
Urinary tract infection in iNOS-deficient mice with focus on bacterial sensitivity to nitric oxide.
Topics: Animals; Antibodies; Colony Count, Microbial; Escherichia coli; Escherichia coli Infections; Female; Genotype; Immunohistochemistry; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nephritis; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Peroxidase; Peroxynitrous Acid; Tyrosine; Urinary Tract Infections | 2003 |
Peroxynitrite generated in the rat spinal cord induces oxidation and nitration of proteins: reduction by Mn (III) tetrakis (4-benzoic acid) porphyrin.
Topics: 2,4-Dinitrophenol; Animals; Drug Interactions; Enzyme Inhibitors; Free Radical Scavengers; Immunohistochemistry; Male; Metalloporphyrins; Microdialysis; Molsidomine; Neurons; Oxidation-Reduction; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Cord Injuries; Time Factors; Tyrosine | 2003 |
Peroxynitrite-induced inhibition and nitration of cardiac myofibrillar creatine kinase.
Topics: Blotting, Western; Creatine Kinase; Cysteine; Dose-Response Relationship, Drug; Kinetics; Myocardium; Myofibrils; Nitrates; Peroxynitrous Acid; Reactive Nitrogen Species; Tyrosine | 2002 |
Tyrosine-nitration of caspase 3 and cytochrome c does not suppress apoptosis induction in squamous cell carcinoma cells.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Carcinoma, Squamous Cell; Caspase 3; Caspases; Cell Survival; Cytochrome c Group; Enzyme Activation; Enzyme Precursors; HeLa Cells; Humans; Mouth Neoplasms; Nitric Oxide; Nitric Oxide Donors; Nitrosation; Peroxynitrous Acid; Poly(ADP-ribose) Polymerases; Precipitin Tests; Superoxides; Tumor Cells, Cultured; Tyrosine | 2003 |
Transmembrane nitration of hydrophobic tyrosyl peptides. Localization, characterization, mechanism of nitration, and biological implications.
Topics: Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Electron Spin Resonance Spectroscopy; Fatty Acids; Free Radicals; Lipid Bilayers; Lipid Metabolism; Liposomes; Membranes, Artificial; Nitric Oxide Donors; Nitrogen; Nitrogen Oxides; Oxygen; Peptide Biosynthesis; Peptides; Peroxynitrous Acid; Spectrometry, Fluorescence; Spermine; Time Factors; Tyrosine | 2003 |
Specific nitration at tyrosine 430 revealed by high resolution mass spectrometry as basis for redox regulation of bovine prostacyclin synthase.
Topics: Amino Acid Sequence; Animals; Aorta; Cattle; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Endothelium, Vascular; Intramolecular Oxidoreductases; Microsomes; Molecular Sequence Data; Muscle, Smooth, Vascular; Nitrates; Oxidation-Reduction; Peptide Fragments; Peroxynitrous Acid; Spectrometry, Mass, Electrospray Ionization; Thermolysin; Trypsin; Tyrosine | 2003 |
Regulation of nitric oxide production in limb and ventilatory muscles during chronic exercise training.
Topics: Animals; Arginine; Argininosuccinate Lyase; Argininosuccinate Synthase; Immunoblotting; Isoenzymes; Male; Muscle, Skeletal; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Peroxynitrous Acid; Physical Conditioning, Animal; Physical Exertion; Rats; Rats, Sprague-Dawley; Respiratory Muscles; Specific Pathogen-Free Organisms; Tyrosine | 2003 |
Mechanism of vasculitis and aneurysms in Kawasaki disease: role of nitric oxide.
Topics: Aneurysm; Animals; Blotting, Western; Cell Wall; Coronary Vessels; Disease Models, Animal; Hemorrhage; Immunohistochemistry; Inflammation; Lacticaseibacillus casei; Macrophages; Male; Mice; Mucocutaneous Lymph Node Syndrome; Myocardium; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Thrombosis; Time Factors; Tyrosine; Vasculitis | 2003 |
Mutation of tyrosine 190 to alanine eliminates the inactivation of cytochrome P450 2B1 by peroxynitrite.
Topics: Alanine; Amino Acid Substitution; Catalysis; Cytochrome P-450 CYP2B1; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Models, Molecular; Nitric Oxide; Peroxynitrous Acid; Recombinant Proteins; Spectrometry, Mass, Electrospray Ionization; Substrate Specificity; Tyrosine | 2003 |
Inhibition of peroxynitrite-mediated cellular toxicity, tyrosine nitration, and alpha1-antiproteinase inactivation by 3-mercapto-2-methylpentan-1-ol, a novel compound isolated from Allium cepa.
Topics: alpha 1-Antitrypsin; Drug Interactions; Enzyme Inhibitors; Humans; Onions; Pentanols; Peroxynitrous Acid; Sulfhydryl Compounds; Tumor Cells, Cultured; Tyrosine | 2003 |
Prevention of peroxynitrite-induced renal injury through modulation of peroxynitrite production by the Chinese prescription Wen-Pi-Tang.
Topics: Animals; Chromatography, High Pressure Liquid; Creatinine; Drugs, Chinese Herbal; Kidney; Lipid Peroxides; Lipopolysaccharides; Models, Chemical; Nitric Oxide Synthase; Nitrogen; Oxygen; Peroxynitrous Acid; Rats; Rats, Wistar; Reperfusion Injury; Tyrosine; Urea; Xanthine Oxidase | 2002 |
Inhibition of actin polymerization by peroxynitrite modulates neutrophil functional responses.
Topics: Actins; Chemotaxis; Dimerization; Dose-Response Relationship, Drug; Humans; Molsidomine; Neutrophil Activation; Neutrophils; Nitric Oxide Donors; Peroxynitrous Acid; Phagocytosis; Reactive Oxygen Species; Respiratory Burst; Tyrosine | 2003 |
The trypanothione-thiol system in Trypanosoma cruzi as a key antioxidant mechanism against peroxynitrite-mediated cytotoxicity.
Topics: Animals; Antioxidants; Biochemistry; Blotting, Western; Chromatography, High Pressure Liquid; Disulfides; Dose-Response Relationship, Drug; Glutathione; Macrophages; Models, Chemical; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitrogen; Oxygen; Peroxynitrous Acid; Sulfhydryl Compounds; Time Factors; Trypanosoma cruzi; Tyrosine | 2003 |
Induction of inducible nitric oxide synthase, argininosuccinate synthase, and GTP cyclohydrolase I in arthritic joints of human tumor necrosis factor-alpha transgenic mice.
Topics: Animals; Argininosuccinate Synthase; Arthritis; Gene Expression Regulation, Enzymologic; GTP Cyclohydrolase; Humans; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Transgenic; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Oxidative Stress; Penetrance; Peroxynitrous Acid; Phenotype; RNA, Messenger; Synovial Membrane; Tumor Necrosis Factor-alpha; Tyrosine | 2003 |
The nNOS inhibitor, AR-R17477AR, prevents the loss of NF68 immunoreactivity induced by methamphetamine in the mouse striatum.
Topics: Animals; Body Temperature; Brain Chemistry; Corpus Striatum; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Drug Administration Schedule; Enzyme Inhibitors; Fever; Homovanillic Acid; Male; Methamphetamine; Mice; Mice, Inbred C57BL; Neurofilament Proteins; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxidative Stress; Peroxynitrous Acid; Temperature; Tyrosine | 2003 |
Peroxynitrite-induced oxidation and its effects on isolated proteasomal systems.
Topics: Anilino Naphthalenesulfonates; Animals; Blotting, Western; Brain; Caseins; Cattle; Cysteine Endopeptidases; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Free Radicals; Kinetics; Multienzyme Complexes; Oxygen; Peptides; Peroxynitrous Acid; Proteasome Endopeptidase Complex; Protein Binding; Protein Conformation; Spectrometry, Fluorescence; Thymus Gland; Tryptophan; Tyrosine | 2003 |
Hypoxia-ischemia induces thioredoxin expression and nitrotyrosine formation in new-born rat brain.
Topics: Animals; Animals, Newborn; Blotting, Northern; Brain; Hypoxia; Models, Anatomic; Oxidants; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Reperfusion Injury; RNA, Messenger; Thioredoxins; Time Factors; Tyrosine | 2002 |
Dependence of liver injury after hemorrhage/resuscitation in mice on NADPH oxidase-derived superoxide.
Topics: Alanine Transaminase; Animals; Chemotaxis, Leukocyte; Ischemia; Lipid Peroxidation; Liver; Mice; Mice, Inbred C57BL; Mice, Knockout; NADPH Oxidases; Necrosis; Neutrophils; Oxidative Stress; Peroxynitrous Acid; Phosphoproteins; Reperfusion Injury; Resuscitation; Shock, Hemorrhagic; Superoxides; Tyrosine | 2003 |
Selective nitration of Tyr99 in calmodulin as a marker of cellular conditions of oxidative stress.
Topics: Amino Acid Sequence; Animals; Biomarkers; Calmodulin; Chickens; Molecular Sequence Data; Nitrates; Oxidative Stress; Peroxynitrous Acid; Tyrosine | 2003 |
Modifications of tyrosine and catecholamines by peroxynitrite, nitrite and nitrate.
Topics: Catecholamines; Nitrates; Nitrites; Peroxynitrous Acid; Tyrosine | 2003 |
Mass mapping sites of nitration in tyrosine hydroxylase: random vs selective nitration of three tyrosine residues.
Topics: Binding Sites; Chromatography, Liquid; Mass Spectrometry; Peptide Fragments; Peptide Mapping; Peroxynitrous Acid; Protein Binding; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Time Factors; Tyrosine | 2003 |
Histone H1.2 is a substrate for denitrase, an activity that reduces nitrotyrosine immunoreactivity in proteins.
Topics: Animals; Cell Line; Cell Membrane; Deoxyribonucleases; Histones; Hydrolases; Kinetics; Macrophages; Mice; Peroxynitrous Acid; Proteins; Substrate Specificity; Trypsin; Tyrosine | 2003 |
Tyrosine nitration of a synaptic protein synaptophysin contributes to amyloid beta-peptide-induced cholinergic dysfunction.
Topics: Acetylcholine; Amyloid beta-Peptides; Animals; Cerebral Ventricles; Hippocampus; Infusions, Parenteral; Male; Microdialysis; Peptide Fragments; Peroxynitrous Acid; Rats; Rats, Wistar; Synaptophysin; Tyrosine | 2003 |
Experimental diabetes causes breakdown of the blood-retina barrier by a mechanism involving tyrosine nitration and increases in expression of vascular endothelial growth factor and urokinase plasminogen activator receptor.
Topics: Animals; Blood-Retinal Barrier; Body Weight; Diabetes Mellitus, Experimental; Endothelial Growth Factors; Enzyme Inhibitors; Gene Expression; Intercellular Signaling Peptides and Proteins; Lipid Peroxidation; Lymphokines; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide Synthase; Nitrites; Oxidative Stress; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Reactive Nitrogen Species; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; Retina; RNA, Messenger; Tyrosine; Uric Acid; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2003 |
Differential effects of quercetin and resveratrol on Band 3 tyrosine phosphorylation signalling of red blood cells.
Topics: Anion Exchange Protein 1, Erythrocyte; Antioxidants; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Precursors; Erythrocyte Membrane; Erythrocytes; Humans; Intracellular Signaling Peptides and Proteins; Peroxynitrous Acid; Phosphorylation; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Quercetin; Resveratrol; Signal Transduction; src-Family Kinases; Stilbenes; Syk Kinase; Tyrosine | 2003 |
Dopamine prevents nitration of tyrosine hydroxylase by peroxynitrite and nitrogen dioxide: is nitrotyrosine formation an early step in dopamine neuronal damage?
Topics: 3,4-Dihydroxyphenylacetic Acid; Cell Line; Dihydroxyphenylalanine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Gene Expression; Glutathione Transferase; Green Fluorescent Proteins; Humans; Hydrogen-Ion Concentration; Luminescent Proteins; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Nitrates; Nitrogen Dioxide; Peroxynitrous Acid; Recombinant Fusion Proteins; Tyrosine; Tyrosine 3-Monooxygenase | 2003 |
A novel model for rapid induction of apoptosis in spiral ganglions of mice.
Topics: Animals; Apoptosis; Cell Death; Cisplatin; Disease Models, Animal; In Situ Nick-End Labeling; Intermediate Filament Proteins; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Peripherins; Peroxynitrous Acid; Spiral Ganglion; Tyrosine | 2003 |
Distribution of protein nitrotyrosine in synovial tissues of patients with rheumatoid arthritis and osteoarthritis.
Topics: Aged; Aged, 80 and over; Arthritis, Rheumatoid; Blotting, Western; Female; Humans; Immunohistochemistry; Male; Middle Aged; Osteoarthritis; Peroxynitrous Acid; Staining and Labeling; Synovial Membrane; Tyrosine | 2003 |
Proteomic identification of nitrated proteins in Alzheimer's disease brain.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Blotting, Western; Brain Chemistry; Electrophoresis, Gel, Two-Dimensional; Female; Humans; Male; Nerve Tissue Proteins; Nitrates; Oxidative Stress; Peroxynitrous Acid; Phosphopyruvate Hydratase; Proteins; Proteomics; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Triose-Phosphate Isomerase; Tyrosine | 2003 |
Protective activity of (-)-epicatechin 3-O-gallate against peroxynitrite-mediated renal damage.
Topics: Animals; Antioxidants; Caspases; Catechin; Cell Cycle; Cell Line; Cell Survival; DNA Fragmentation; Dose-Response Relationship, Drug; Flow Cytometry; Glutathione; Glutathione Peroxidase; Kidney; Lipid Peroxides; Lipopolysaccharides; LLC-PK1 Cells; Male; Molsidomine; Peroxynitrous Acid; Rats; Rats, Wistar; Reactive Oxygen Species; Reperfusion Injury; Rhodamines; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Time Factors; Tyrosine | 2003 |
Hyperlipidemia induced by a cholesterol-rich diet leads to enhanced peroxynitrite formation in rat hearts.
Topics: Animals; Biomarkers; Cholesterol, Dietary; Hyperlipidemias; Male; Malondialdehyde; Models, Animal; Myocardium; Nitric Oxide; Nitric Oxide Synthase; Peroxynitrous Acid; Rats; Rats, Wistar; Superoxide Dismutase; Superoxides; Tyrosine; Xanthine Dehydrogenase | 2003 |
Role of nitric oxide and peroxynitrite anion in lung injury induced by intestinal ischemia-reperfusion in rats.
Topics: Animals; Anions; Lung; Male; Malondialdehyde; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Peroxynitrous Acid; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Tyrosine | 2003 |
Beneficial effects of low-dose benidipine in acute autoimmune myocarditis: suppressive effects on inflammatory cytokines and inducible nitric oxide synthase.
Topics: Acute Disease; Animals; Autoimmune Diseases; Blood Pressure; Calcium Channel Blockers; Calcium Channels, L-Type; Cytokines; Dihydropyridines; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Heart Rate; Myocarditis; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Rats; Rats, Inbred Lew; Tyrosine | 2003 |
Effects of peroxynitrite on isolated cardiac trabeculae: selective impact on myofibrillar energetic controllers.
Topics: Adenosine Triphosphatases; Animals; Creatine Kinase; Energy Metabolism; Heart; Male; Myocardial Contraction; Myocardium; Nitrates; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Tyrosine | 2003 |
Enhanced peroxynitrite decomposition protects against experimental obliterative bronchiolitis.
Topics: Animals; Bronchiolitis Obliterans; Image Processing, Computer-Assisted; Immunohistochemistry; Male; Metalloporphyrins; Models, Animal; Peroxynitrous Acid; Rats; Rats, Inbred BN; Rats, Inbred Lew; Respiratory Mucosa; Trachea; Transplantation, Homologous; Transplantation, Isogeneic; Tyrosine | 2003 |
PARP inhibition improves the effectiveness of neural stem cell transplantation in experimental brain trauma.
Topics: Animals; Brain Injuries; Disease Models, Animal; Enzyme Inhibitors; Male; Microscopy, Confocal; Motor Cortex; Neurons; Peroxynitrous Acid; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Rats; Rats, Wistar; Stem Cell Transplantation; Stem Cells; Tyrosine | 2003 |
Oxidative damage to mitochondrial complex I due to peroxynitrite: identification of reactive tyrosines by mass spectrometry.
Topics: Amino Acid Sequence; Animals; Cattle; Electron Transport Complex I; Humans; Mass Spectrometry; Molecular Sequence Data; Neurodegenerative Diseases; Oxidation-Reduction; Oxidative Stress; Peroxynitrous Acid; Protein Subunits; Tyrosine | 2003 |
Nitrotyrosine in peripheral vascular disease.
Topics: Aged; Case-Control Studies; Endothelium, Vascular; Female; Humans; Male; Middle Aged; Oxidants; Peripheral Vascular Diseases; Peroxynitrous Acid; Tyrosine | 2003 |
Critical role of reactive nitrogen species in lung ischemia-reperfusion injury.
Topics: Animals; Bronchoalveolar Lavage Fluid; Capillary Permeability; Chemokines; Disease Models, Animal; Immunohistochemistry; Inflammation Mediators; Macrophages, Alveolar; Male; Models, Cardiovascular; NF-kappa B; Peroxidase; Peroxynitrous Acid; Rats; Rats, Long-Evans; Reactive Nitrogen Species; Reperfusion Injury; Respiratory Distress Syndrome; Severity of Illness Index; Statistics as Topic; Transcription Factor AP-1; Transcriptional Activation; Tyrosine | 2003 |
Evidence of an electron-transfer mechanism in the peroxynitrite-mediated oxidation of 4-alkylphenols and tyrosine.
Topics: Carbon Dioxide; Electron Spin Resonance Spectroscopy; Electron Transport; Free Radicals; Gas Chromatography-Mass Spectrometry; Hydrogen-Ion Concentration; Hydroxyl Radical; Oxidation-Reduction; Peroxynitrous Acid; Phenols; Tyrosine | 2003 |
Tetrahydrobiopterin and antioxidants reverse the coronary endothelial dysfunction associated with left ventricular hypertrophy in a porcine model.
Topics: Animals; Antioxidants; Arginine; Biomarkers; Bradykinin; Catalase; Coronary Vessels; Dose-Response Relationship, Drug; Echocardiography; Endothelium, Vascular; Female; Hemodynamics; Hypertrophy, Left Ventricular; In Vitro Techniques; Ketanserin; Male; Models, Animal; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxidative Stress; Peroxynitrous Acid; Pterins; Serotonin; Serotonin Antagonists; Superoxide Dismutase; Swine; Tyrosine | 2003 |
Reaction of human hemoglobin with peroxynitrite. Isomerization to nitrate and secondary formation of protein radicals.
Topics: Blotting, Western; Cyclic N-Oxides; Dimerization; Electron Spin Resonance Spectroscopy; Electrophoresis, Polyacrylamide Gel; Globins; Humans; Hydrogen Peroxide; Immunohistochemistry; Iron; Isomerism; Methemoglobin; Nitrates; Nitrites; Oxygen; Oxyhemoglobins; Peroxynitrous Acid; Spectrophotometry; Spin Labels; Superoxides; Tyrosine | 2003 |
Sulfenic acid formation in human serum albumin by hydrogen peroxide and peroxynitrite.
Topics: 4-Chloro-7-nitrobenzofurazan; Disulfides; Fluorescent Dyes; Free Radicals; Glutathione; Humans; Hydrogen Peroxide; Kinetics; Oxidants; Oxidation-Reduction; Oxygen; Peroxynitrous Acid; Serum Albumin; Sulfenic Acids; Sulfhydryl Compounds; Tyrosine | 2003 |
Role of calcium and superoxide dismutase in sensitizing mitochondria to peroxynitrite-induced permeability transition.
Topics: Animals; Calcium; Cytochromes c; Drug Administration Schedule; In Vitro Techniques; Ion Channels; Male; Mitochondria, Liver; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Mitochondrial Proteins; Peroxynitrous Acid; Proteomics; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Tyrosine | 2004 |
Effect of high glucose on vasculature.
Topics: Animals; Blood Vessels; Cells, Cultured; Diabetes Mellitus; Endothelium, Vascular; Enzyme Activation; Glucose; Heart; Humans; Hyperglycemia; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Peroxynitrous Acid; Rats; Superoxides; Tyrosine; Up-Regulation | 2003 |
C-reactive protein decreases prostacyclin release from human aortic endothelial cells.
Topics: Aorta; Ascorbic Acid; C-Reactive Protein; Cells, Cultured; Coronary Vessels; Cytochrome P-450 Enzyme System; Endothelium, Vascular; Epoprostenol; Free Radical Scavengers; Humans; Intramolecular Oxidoreductases; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Prostaglandins F; Tyrosine; Uric Acid | 2003 |
Mechanism of peroxynitrite interaction with cytochrome c.
Topics: Amino Acids; Bicarbonates; Cytochromes c; Heme; Hydrogen Peroxide; Kinetics; Oxidation-Reduction; Peroxynitrous Acid; Protein Conformation; Spectrophotometry; Tyrosine | 2003 |
Inactivation of NADP+-dependent isocitrate dehydrogenase by peroxynitrite. Implications for cytotoxicity and alcohol-induced liver injury.
Topics: Animals; Cell Line; Dose-Response Relationship, Drug; Enzyme Activation; Ethanol; Humans; Isocitrate Dehydrogenase; Kinetics; Male; Mitochondria, Liver; Mitochondrial Proteins; Peroxides; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Sulfhydryl Compounds; Swine; Tyrosine | 2003 |
Relationship between protein nitration and oxidation and development of hyperoxic seizures.
Topics: Animals; Brain; Brain Chemistry; Electroencephalography; Enzyme Inhibitors; Hyperbaric Oxygenation; Indazoles; Male; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Oxygen; Peroxynitrous Acid; Proteins; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Seizures; Superoxide Dismutase; Time Factors; Tyrosine | 2003 |
Peroxynitrite modulates acidic fibroblast growth factor (FGF-1) activity.
Topics: 3T3 Cells; Amino Acids; Animals; Cell Count; Cell Division; Dose-Response Relationship, Drug; Fibroblast Growth Factor 1; Humans; Mice; Nitrates; Oxidation-Reduction; Peroxynitrous Acid; Tyrosine | 2003 |
Proteomic identification of age-dependent protein nitration in rat skeletal muscle.
Topics: Age Distribution; Animals; Blotting, Western; Creatine Kinase; Electrophoresis, Gel, Two-Dimensional; Energy Metabolism; Fructose-Bisphosphate Aldolase; Motor Activity; Muscle, Skeletal; Peroxynitrous Acid; Phosphopyruvate Hydratase; Proteomics; Rats; Rats, Inbred F344; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tyrosine | 2003 |
Alveolar macrophage cytotoxicity for normal lung fibroblasts is mediated by nitric oxide release.
Topics: Animals; Cell Culture Techniques; Cell Survival; Coculture Techniques; Culture Media; Dose-Response Relationship, Drug; Drug Combinations; Drug Evaluation, Preclinical; Drug Synergism; Fibroblasts; Interferon-gamma; Interleukin-1; Lipopolysaccharides; Lung; Macrophages, Alveolar; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Tumor Necrosis Factor-alpha; Tyrosine | 2004 |
Bicarbonate enhances alpha-synuclein oligomerization and nitration: intermediacy of carbonate radical anion and nitrogen dioxide radical.
Topics: alpha-Synuclein; Anions; Bicarbonates; Cyclic N-Oxides; Dimerization; Free Radicals; Hydrogen Peroxide; Hydroxylation; Liposomes; Nerve Tissue Proteins; Nitric Oxide Donors; Nitrogen Dioxide; Nitrogen Oxides; Oxidation-Reduction; Peroxidase; Peroxynitrous Acid; Reactive Nitrogen Species; Spin Labels; Superoxide Dismutase; Superoxide Dismutase-1; Synucleins; Tyrosine | 2004 |
Reactive nitrogen species scavenging, rather than nitric oxide inhibition, protects from articular cartilage damage in rat zymosan-induced arthritis.
Topics: Animals; Arthritis, Experimental; Cartilage, Articular; Disease Models, Animal; Dose-Response Relationship, Drug; Free Radical Scavengers; Glycosaminoglycans; Guanidines; Injections, Intra-Articular; Injections, Intraperitoneal; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Peroxynitrous Acid; Rats; Rats, Wistar; Reactive Nitrogen Species; Synovial Fluid; Synovial Membrane; Synovitis; Tyrosine; Uric Acid; Zymosan | 2004 |
Neuroprotective effect of curcumin in middle cerebral artery occlusion induced focal cerebral ischemia in rats.
Topics: Animals; Behavior, Animal; Body Temperature; Brain; Brain Edema; Brain Ischemia; Cerebrovascular Circulation; Curcumin; Fluorescent Antibody Technique; Glutathione Peroxidase; Infarction, Middle Cerebral Artery; Lipid Peroxidation; Male; Neuroprotective Agents; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Tyrosine | 2004 |
CD95-tyrosine nitration inhibits hyperosmotic and CD95 ligand-induced CD95 activation in rat hepatocytes.
Topics: Animals; Apoptosis; Bacterial Proteins; Cell Line; Cell Line, Tumor; Cell Membrane; ErbB Receptors; Fas Ligand Protein; fas Receptor; Hepatocytes; Humans; In Situ Nick-End Labeling; JNK Mitogen-Activated Protein Kinases; Liver; Luminescent Proteins; Male; MAP Kinase Kinase 4; Membrane Glycoproteins; Mitogen-Activated Protein Kinase Kinases; Nitrogen; Peroxynitrous Acid; Phosphorylation; Plasmids; Precipitin Tests; Rats; Rats, Wistar; Time Factors; Tyrosine | 2004 |
A novel competitive ELISA for both free and protein-bound nitrotyrosine.
Topics: Animals; Antibodies, Monoclonal; Binding, Competitive; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Glutaral; Humans; Mice; Peroxynitrous Acid; Phenylalanine; Phosphotyrosine; Protein Binding; Reactive Nitrogen Species; Tyrosine | 2003 |
Lipoic acid protects efficiently only against a specific form of peroxynitrite-induced damage.
Topics: Antioxidants; Dose-Response Relationship, Drug; Glutathione; Glutathione S-Transferase pi; Glutathione Transferase; Hypochlorous Acid; Inhibitory Concentration 50; Isoenzymes; Models, Biological; Models, Chemical; Nitric Oxide; Oxygen; Peroxynitrous Acid; Potassium; Protein Binding; Rhodamines; Sulfur; Thioctic Acid; Tyrosine | 2004 |
Selective scavenging property of the indole moiety for the nitrating species of peroxynitrite.
Topics: Chromatography, High Pressure Liquid; Diterpenes; Free Radical Scavengers; Free Radicals; Indicators and Reagents; Indoles; Kinetics; Magnetic Resonance Spectroscopy; Oxidation-Reduction; Peroxynitrous Acid; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Tyrosine | 2004 |
Effects of oxygen on the reactivity of nitrogen oxide species including peroxynitrite.
Topics: Anaerobiosis; Electron Spin Resonance Spectroscopy; Glutathione; Molsidomine; Morpholines; Nitric Oxide; Nitrogen Oxides; Nitrosamines; Nitrous Oxide; Oxygen; Peroxynitrous Acid; S-Nitrosoglutathione; Solutions; Tyrosine | 2004 |
Distribution of 3-nitrotyrosine in the nasal polyps of atopic patients.
Topics: Adult; Case-Control Studies; Eosinophils; Female; Humans; Hypersensitivity, Immediate; Immunohistochemistry; Male; Nasal Mucosa; Nasal Polyps; Peroxynitrous Acid; Retrospective Studies; Tyrosine | 2004 |
Selective prion protein binding to synaptic components is modulated by oxidative and nitrosative changes induced by copper(II) and peroxynitrite in cholinergic synaptosomes, unveiling a role for calcineurin B and thioredoxin.
Topics: 14-3-3 Proteins; Animals; Blotting, Western; Calcineurin; Carbocyanines; Choline O-Acetyltransferase; Copper Sulfate; Cyclophilin A; Cysteine; Dose-Response Relationship, Drug; Epitopes; Humans; In Vitro Techniques; Membrane Glycoproteins; Membrane Proteins; Mercaptoethanol; Nerve Tissue Proteins; Neurons; Nitrosation; Oxidation-Reduction; Peroxynitrous Acid; Prions; Protein Binding; Pyruvic Acid; Qa-SNARE Proteins; R-SNARE Proteins; Recombinant Proteins; S-Nitrosothiols; Sheep; Synapsins; Synaptic Vesicles; Synaptosomes; Tacrolimus Binding Proteins; Thioredoxins; Time Factors; Torpedo; Tyrosine; Tyrosine 3-Monooxygenase | 2003 |
Use of a novel double-sandwich enzyme-linked immunosorbent assay method for assaying chondroitin sulfate proteoglycans that bear 3-nitrotyrosine core protein modifications, a previously unrecognized proteoglycan modification in hydrocephalus.
Topics: Animals; Blotting, Western; Cattle; Chick Embryo; Chondroitin Sulfate Proteoglycans; Enzyme-Linked Immunosorbent Assay; Humans; Hydrocephalus; Infant, Newborn; Infant, Premature; Peroxynitrous Acid; Rabbits; Sensitivity and Specificity; Serum Albumin, Bovine; Tyrosine | 2004 |
Involvement of nitric oxide on kainate-induced toxicity in oligodendrocyte precursors.
Topics: Animals; Animals, Newborn; Cell Count; Cell Death; Cells, Cultured; Culture Media; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Fluorescent Antibody Technique; Kainic Acid; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oligodendroglia; Peroxynitrous Acid; Quinoxalines; Rats; Rats, Wistar; Spinal Cord; Stem Cells; Tyrosine | 2003 |
Peroxynitrite delivery methods for toxicity studies.
Topics: Animals; Cells, Cultured; Dimerization; Drug Delivery Systems; Humans; Hypoxanthine; Models, Chemical; Nitrates; Nitric Oxide; Oxidation-Reduction; Peroxynitrous Acid; Toxicity Tests; Tyrosine; Uric Acid; Xanthine Oxidase | 2004 |
Peroxynitrite and caspase-3 expression after ischemia/reperfusion in mouse cardiac arrest model.
Topics: Animals; Brain Ischemia; Caspase 3; Caspases; Heart Arrest, Induced; Immunohistochemistry; Male; Mice; Mice, Inbred BALB C; Peroxynitrous Acid; Reperfusion Injury; Time Factors; Tyrosine | 2003 |
Acetaminophen toxicity in mice lacking NADPH oxidase activity: role of peroxynitrite formation and mitochondrial oxidant stress.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Endothelium, Vascular; Glutathione; Glutathione Disulfide; Hepatocytes; Hydrogen Peroxide; Macrophages; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria, Liver; NADPH Oxidase 2; NADPH Oxidases; Oxidative Stress; Peroxynitrous Acid; Superoxides; Tyrosine | 2003 |
Potential role of methionine sulfoxide in the inactivation of the chaperone GroEL by hypochlorous acid (HOCl) and peroxynitrite (ONOO-).
Topics: Amino Acid Sequence; Arteriosclerosis; Chaperonin 60; Chromatography; Chromatography, High Pressure Liquid; Electrophoresis, Polyacrylamide Gel; Humans; Hydrolysis; Hypochlorous Acid; Mass Spectrometry; Methionine; Methionine Sulfoxide Reductases; Molecular Chaperones; Molecular Sequence Data; Oxidants; Oxidoreductases; Oxygen; Peptides; Peroxynitrous Acid; Phagocytes; Protein Binding; Time Factors; Trypsin; Tyrosine | 2004 |
Formation of protein tyrosine ortho-semiquinone radical and nitrotyrosine from cytochrome c-derived tyrosyl radical.
Topics: Animals; Apoptosis; Blotting, Western; Cell Line; Chickens; Cytochromes c; Electron Spin Resonance Spectroscopy; Electrophoresis, Polyacrylamide Gel; Free Radicals; Horses; Hydrogen Peroxide; Immunoblotting; Magnetics; Models, Chemical; Muramidase; Nitric Oxide; Nitrites; Oxygen; Peroxynitrous Acid; Rats; Superoxide Dismutase; Time Factors; Tyrosine | 2004 |
Melatonin reduces peroxynitrite-induced injury in aortic smooth muscle cells.
Topics: Animals; Aorta; Cell Survival; Cells, Cultured; DNA Damage; Free Radical Scavengers; Malondialdehyde; Melatonin; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Tyrosine | 2004 |
Nitrotyrosine, dityrosine, and nitrotryptophan formation from metmyoglobin, hydrogen peroxide, and nitrite.
Topics: Hydrogen Peroxide; Methemoglobin; Metmyoglobin; Myoglobin; Nitrites; Peroxidase; Peroxynitrous Acid; Tryptophan; Tyrosine | 2004 |
Peroxynitrite-mediated protein nitration and lipid peroxidation in a mouse model of traumatic brain injury.
Topics: Aldehydes; Animals; Brain; Brain Injuries; Disease Models, Animal; Image Processing, Computer-Assisted; Immunohistochemistry; Lipid Peroxidation; Male; Mice; Nerve Degeneration; Peroxynitrous Acid; Proteins; Time Factors; Tyrosine | 2004 |
Linoleic acid-induced endothelial activation: role of calcium and peroxynitrite signaling.
Topics: Animals; Borohydrides; Calcium; Calcium Signaling; Cells, Cultured; E-Selectin; Endothelium, Vascular; Gene Expression Regulation; Linoleic Acid; Models, Biological; NF-kappa B; Nitric Oxide; Peroxynitrous Acid; Pulmonary Artery; Swine; Tyrosine | 2004 |
Oxidative stress reduces histone deacetylase 2 activity and enhances IL-8 gene expression: role of tyrosine nitration.
Topics: Cell Line; Cell Nucleus; Cytokines; DNA; Dose-Response Relationship, Drug; Gene Expression Regulation, Enzymologic; Genetic Techniques; Histone Deacetylase 2; Histone Deacetylases; Histones; Humans; Hydrogen Peroxide; Interleukin-1; Interleukin-8; NF-kappa B; Nitrates; Oxidative Stress; Peroxynitrous Acid; Precipitin Tests; Promoter Regions, Genetic; Repressor Proteins; Time Factors; Tyrosine | 2004 |
Interference of the polyphenol epicatechin with the biological chemistry of nitric oxide- and peroxynitrite-mediated reactions.
Topics: Catechin; Cyclic GMP; Flavonoids; HL-60 Cells; Humans; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidation-Reduction; Peroxynitrous Acid; Phenols; Polyphenols; Signal Transduction; Tyrosine | 2004 |
Peroxynitrite-mediated oxidative modification of low-density lipoprotein by aqueous extracts of cigarette smoke and the preventive effect of fluvastatin.
Topics: Animals; Antioxidants; Apolipoproteins; Fatty Acids, Monounsaturated; Female; Fluvastatin; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; In Vitro Techniques; Indoles; Lipoproteins, LDL; Male; Oxidation-Reduction; Oxidative Stress; Peroxynitrous Acid; Rabbits; Smoking; Tyrosine; Vitamin E | 2004 |
Nitric oxide, oxidants, and protein tyrosine nitration.
Topics: Animals; Erythrocytes; Hemoglobins; Humans; Mitochondria; Nitrates; Nitric Oxide; Oxidants; Peroxynitrous Acid; Superoxides; Tyrosine | 2004 |
Possible involvement of nitric oxide and peroxynitrite in the pathogenesis of human vocal polyps and nodules.
Topics: Adult; Aged; Antibodies; Female; Humans; Immunohistochemistry; Male; Middle Aged; Nitric Oxide; Peroxynitrous Acid; Polyps; Tyrosine; Vocal Cords | 2005 |
The nitric oxide synthase inhibitor N(G)-nitro-L-arginine decreases defibrillation-induced free radical generation.
Topics: Animals; Ascorbic Acid; Dogs; Electric Countershock; Electron Spin Resonance Spectroscopy; Enzyme Inhibitors; Free Radicals; Histocytochemistry; Myocardium; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Peroxynitrous Acid; Superoxides; Tyrosine | 2004 |
Reperfusion-induced oxidative/nitrative injury to neurovascular unit after focal cerebral ischemia.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Ischemia; Coloring Agents; Enzyme Inhibitors; Evans Blue; Matrix Metalloproteinase 9; Mice; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Peroxynitrous Acid; Reperfusion Injury; Superoxides; Tyrosine | 2004 |
The impact of metal catalysis on protein tyrosine nitration by peroxynitrite.
Topics: Catalysis; Metals; Peroxynitrous Acid; Proteins; Sensitivity and Specificity; Tyrosine | 2004 |
Tetrahydrobiopterin improves endothelial dysfunction and vascular oxidative stress in microvessels of intrauterine undernourished rats.
Topics: Animals; Antioxidants; Biopterins; Blotting, Western; Caloric Restriction; Endothelium, Vascular; Female; Fetal Nutrition Disorders; Male; Microcirculation; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxidative Stress; Peroxynitrous Acid; Pregnancy; Rats; Rats, Wistar; RNA, Messenger; Superoxides; Tyrosine; Uterus; Vasodilation | 2004 |
Hypoosmotic swelling increases protein tyrosine nitration in cultured rat astrocytes.
Topics: Animals; Animals, Newborn; Astrocytes; Brain Edema; Calcium Signaling; Calmodulin; Cell Size; Cells, Cultured; Chelating Agents; Excitatory Amino Acid Antagonists; Hepatic Encephalopathy; Hyperammonemia; Hypotonic Solutions; Nerve Tissue Proteins; Nitrates; Nitric Oxide; Osmolar Concentration; Oxidative Stress; Peroxynitrous Acid; Proteins; Rats; Rats, Wistar; Reactive Oxygen Species; Receptors, N-Methyl-D-Aspartate; Tyrosine | 2004 |
Mechanistic studies of the isomerization of peroxynitrite to nitrate catalyzed by distal histidine metmyoglobin mutants.
Topics: Animals; Catalysis; Chromatography, High Pressure Liquid; Globins; Heme; Histidine; Hydrogen-Ion Concentration; Isomerism; Kinetics; Metmyoglobin; Mutation; Nitrates; Nitrogen; Peroxynitrous Acid; Tyrosine; Whales | 2004 |
Characterization of antioxidant and antiglycation properties and isolation of active ingredients from traditional chinese medicines.
Topics: Antioxidants; Ascorbic Acid; Benzothiazoles; Chromatography, High Pressure Liquid; Clusiaceae; DNA Damage; Dose-Response Relationship, Drug; Hypochlorous Acid; Lipid Peroxidation; Lipids; Mass Spectrometry; Medicine, Chinese Traditional; Models, Chemical; Nitrogen; Peroxynitrous Acid; Phenol; Phospholipids; Sulfonic Acids; Superoxides; Tyrosine; Xanthine Oxidase; Xanthones | 2004 |
Mass spectrometric characterization of the oxidation of the fluorescent lipid peroxidation reporter molecule C11-BODIPY(581/591).
Topics: Animals; Boron Compounds; Chromatography, High Pressure Liquid; Coloring Agents; Fibroblasts; Free Radicals; Genes, Reporter; Lipid Peroxidation; Mass Spectrometry; Microscopy, Fluorescence; Models, Chemical; Oxidative Stress; Oxygen; Peroxynitrous Acid; Rats; Reactive Nitrogen Species; Reactive Oxygen Species; Spectrometry, Fluorescence; Spectrometry, Mass, Electrospray Ionization; Time Factors; Tyrosine | 2004 |
Peroxynitrite decomposition catalysts prevent myocardial dysfunction and inflammation in endotoxemic rats.
Topics: Animals; Biomarkers; Catalysis; Disease Models, Animal; Endothelium, Vascular; Endotoxemia; Enzyme Inhibitors; Fluorescent Dyes; Guanidines; I-kappa B Proteins; Leukocytes; Metalloporphyrins; Models, Cardiovascular; Myocarditis; NF-kappa B; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha; Tyrosine; Xanthenes | 2004 |
Neuroprotective efficacy and therapeutic time window of peroxynitrite decomposition catalysts in focal cerebral ischemia in rats.
Topics: Animals; Apoptosis; Brain; Brain Edema; Brain Ischemia; Catalysis; DNA Fragmentation; Fluorescent Antibody Technique; In Situ Nick-End Labeling; Infarction, Middle Cerebral Artery; Kinetics; Male; Metalloporphyrins; Microscopy, Electron; Middle Cerebral Artery; Nervous System Diseases; Neuroprotective Agents; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Tyrosine | 2004 |
Modulation of sarcoplasmic reticulum Ca(2+)-ATPase by chronic and acute exposure to peroxynitrite.
Topics: Animals; Blotting, Western; Calcium-Transporting ATPases; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Muscle, Skeletal; Peroxynitrous Acid; Rabbits; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Tyrosine | 2004 |
Peroxynitrite reaction with eye lens proteins: alpha-crystallin retains its activity despite modification.
Topics: alpha-Crystallins; Animals; Cattle; Lens, Crystalline; Molecular Chaperones; Oxidative Stress; Peroxynitrous Acid; Tryptophan; Tyrosine | 2004 |
The effects of antioxidants on peroxynitrite-induced changes in platelet proteins.
Topics: Antioxidants; Blood Platelets; Blood Proteins; Cells, Cultured; Dose-Response Relationship, Drug; Humans; Nitrates; Oxidation-Reduction; Oxidative Stress; Peroxynitrous Acid; Resveratrol; Stilbenes; Tyrosine | 2004 |
Expression of cyclooxygenase-2 and nitric oxide synthase 2 in swine ulcerative colitis caused by Salmonella typhimurium.
Topics: Animals; Colitis, Ulcerative; Cyclooxygenase 2; DNA Primers; Immunohistochemistry; Isoenzymes; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Polymerase Chain Reaction; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Salmonella Infections, Animal; Salmonella typhimurium; Swine; Swine Diseases; Tyrosine | 2004 |
Tyrosine nitration of carnitine palmitoyl transferase I during endotoxaemia in suckling rats.
Topics: Acyl Coenzyme A; Animals; Animals, Newborn; Blotting, Western; Carnitine O-Palmitoyltransferase; Endotoxemia; Female; Heart; Male; Mitochondria, Heart; Nitrosation; Peroxynitrous Acid; Precipitin Tests; Rats; Rats, Wistar; Tyrosine | 2004 |
Reduction of insulin-stimulated glucose uptake by peroxynitrite is concurrent with tyrosine nitration of insulin receptor substrate-1.
Topics: 3T3-L1 Cells; Animals; Binding Sites; Dose-Response Relationship, Drug; Glucose; Insulin; Insulin Receptor Substrate Proteins; Mice; Molsidomine; Nitrates; Peroxynitrous Acid; Phosphoproteins; Protein Binding; Rats; Tyrosine | 2004 |
Methylguanidine reduces the development of non septic shock induced by zymosan in mice.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Exudates and Transudates; Immunohistochemistry; Intestinal Mucosa; Intestines; Kidney; Lipid Peroxidation; Lung; Male; Methylguanidine; Mice; Neutrophils; Pancreas; Peritonitis; Peroxidase; Peroxynitrous Acid; Poly(ADP-ribose) Polymerases; Shock; Tyrosine; Zymosan | 2004 |
The novel neuromodulator hydrogen sulfide: an endogenous peroxynitrite 'scavenger'?
Topics: Cell Line; Cell Survival; Dose-Response Relationship, Drug; Free Radical Scavengers; Humans; Hydrogen Sulfide; Neuroblastoma; Neurons; Neurotransmitter Agents; Peroxynitrous Acid; Sulfides; Tyrosine | 2004 |
Endogenous nitration of iron regulatory protein-1 (IRP-1) in nitric oxide-producing murine macrophages: further insight into the mechanism of nitration in vivo and its impact on IRP-1 functions.
Topics: Aconitate Hydratase; Animals; Blotting, Western; Catechin; Cell Line; Cytoplasm; Cytosol; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Ferritins; Hydrogen Peroxide; Interferon-gamma; Iron; Iron Regulatory Protein 1; Iron-Sulfur Proteins; Lipopolysaccharides; Macrophages; Mercaptoethanol; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitrogen; Peroxidases; Peroxynitrous Acid; Protein Binding; Recombinant Proteins; RNA Processing, Post-Transcriptional; RNA, Messenger; Salicylamides; Tetradecanoylphorbol Acetate; Tyrosine | 2004 |
Oxidative stress-induced DNA damage in the synovial cells of the temporomandibular joint in the rat.
Topics: Animals; Disease Models, Animal; DNA Damage; Hyperplasia; Joint Instability; Male; Mandibular Condyle; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidative Stress; Peroxynitrous Acid; Rats; Rats, Wistar; Stress, Mechanical; Synovial Membrane; Synovitis; Temporomandibular Joint; Temporomandibular Joint Disorders; Tyrosine | 2004 |
Nitric oxide generated from isoniazid activation by KatG: source of nitric oxide and activity against Mycobacterium tuberculosis.
Topics: Antitubercular Agents; Bacterial Proteins; Biotransformation; Catalase; Free Radical Scavengers; Isoniazid; Mycobacterium bovis; Mycobacterium tuberculosis; Nitric Oxide; Oxidoreductases; Peroxidase; Peroxynitrous Acid; Prodrugs; Spin Trapping; Tyrosine | 2004 |
Peroxynitrite decreases hemostasis in human plasma in vitro.
Topics: Blood Coagulation Factors; Blotting, Western; Coagulants; Dose-Response Relationship, Drug; Factor X; Hemostasis; Humans; In Vitro Techniques; Molsidomine; Nitric Oxide Donors; Partial Thromboplastin Time; Peroxynitrous Acid; Plasma; Protein C; Prothrombin Time; Superoxide Dismutase; Thrombelastography; Tyrosine | 2004 |
Peroxynitrite inhibition of Coxsackievirus infection by prevention of viral RNA entry.
Topics: Animals; Coxsackievirus Infections; Enterovirus B, Human; HeLa Cells; Humans; Immunity; Mice; Mice, Inbred C3H; Peroxynitrous Acid; RNA, Viral; Transfection; Tyrosine; Viral Structural Proteins; Virus Replication | 2004 |
Human atherosclerotic intima and blood of patients with established coronary artery disease contain high density lipoprotein damaged by reactive nitrogen species.
Topics: Arteries; Arteriosclerosis; Coronary Artery Disease; Coronary Vessels; Dose-Response Relationship, Drug; Epitopes; Gas Chromatography-Mass Spectrometry; Humans; Immunohistochemistry; Inflammation; Lipid Peroxides; Lipoproteins, HDL; Mass Spectrometry; Nitric Oxide; Nitrogen; Oxygen; Peroxidase; Peroxynitrous Acid; Reactive Nitrogen Species; Taurine; Time Factors; Tunica Intima; Tyrosine | 2004 |
Peroxynitrite, a product between nitric oxide and superoxide anion, plays a cytotoxic role in the development of post-bypass systemic inflammatory response.
Topics: Animals; Cardiopulmonary Bypass; Free Radical Scavengers; Inflammation; Interleukin-6; Interleukin-8; Male; Nitrates; Nitric Oxide; Nitrites; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Superoxides; Time Factors; Tyrosine | 2004 |
Interference of 7,8-dihydroneopterin with peroxynitrite-mediated reactions.
Topics: Electron Spin Resonance Spectroscopy; Free Radical Scavengers; Hydroxylation; Luminescent Measurements; Molsidomine; Neopterin; Oxidation-Reduction; Peroxynitrous Acid; Piperidines; Salicylic Acid; Spectrometry, Fluorescence; Superoxides; Tyrosine | 2004 |
Hypoxia-induced dysfunction of rat diaphragm: role of peroxynitrite.
Topics: Animals; Azoles; Diaphragm; Enzyme Inhibitors; Hypoxia; In Vitro Techniques; Isoindoles; Lipid Peroxidation; Male; Muscle Contraction; Muscle Fatigue; omega-N-Methylarginine; Organoselenium Compounds; Peroxynitrous Acid; Rats; Rats, Wistar; Tyrosine | 2005 |
Evidence for the involvement of nitric oxide in 3,4-methylenedioxymethamphetamine-induced serotonin depletion in the rat brain.
Topics: Animals; Brain Chemistry; Citrulline; Dopamine; Enzyme Inhibitors; Fever; Male; Malonates; Microdialysis; N-Methyl-3,4-methylenedioxyamphetamine; Neostriatum; Nerve Tissue Proteins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Peroxynitrous Acid; Rats; Serotonin; Serotonin Agents; Thiourea; Tyrosine | 2005 |
Peroxynitrite decomposition catalyst ameliorates renal damage and protein nitration in cisplatin-induced nephrotoxicity in rats.
Topics: Animals; Body Weight; Catalysis; Cisplatin; Glomerular Mesangium; Kidney Diseases; Kidney Tubules; Male; Metalloporphyrins; Peroxynitrous Acid; Rats; Rats, Wistar; Reactive Nitrogen Species; Tyrosine; Urine | 2004 |
N-acetylcysteine inhibits peroxynitrite-mediated damage in oleic acid-induced lung injury.
Topics: Acetylcysteine; Animals; Female; Lung; Malondialdehyde; Microscopy; Oleic Acid; Peroxidase; Peroxynitrous Acid; Rats; Rats, Wistar; Tyrosine | 2004 |
Peroxynitrite scavenging mode of alaternin isolated from Cassia tora.
Topics: Cassia; Emodin; Free Radical Scavengers; Glucosides; Nitric Oxide; Oxidation-Reduction; Peroxynitrous Acid; Plants, Medicinal; Pyrones; Rhodamines; Serum Albumin, Bovine; Spectrophotometry; Superoxides; Tyrosine | 2004 |
Peroxynitrite decomposition catalyst, iron metalloporphyrin, reduces quinolinate-induced neurotoxicity in rats.
Topics: Animals; Antioxidants; Brain Diseases; Corpus Striatum; Iron; Male; Metalloporphyrins; Neurotoxins; Nitrogen; Oxidative Stress; Peroxynitrous Acid; Quinolinic Acid; Rats; Rats, Wistar; Tyrosine | 2004 |
Nitric oxide inhibits complex I following AMPA receptor activation via peroxynitrite.
Topics: Analysis of Variance; Animals; Antihypertensive Agents; Benzothiadiazines; Cells, Cultured; Cyclic GMP; Drug Interactions; Embryo, Mammalian; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; Immunohistochemistry; Kainic Acid; Microtubule-Associated Proteins; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Peroxynitrous Acid; Proton Pumps; Quinoxalines; Rats; Receptors, AMPA; Tyrosine | 2004 |
Tobacco-related-compound-induced nitrosative stress injury in the hamster cheek pouch.
Topics: Animals; Carcinogens; Cell Survival; Cells, Cultured; Chromatin; Cricetinae; DNA Damage; DNA, Single-Stranded; Dose-Response Relationship, Drug; Mesocricetus; Mouth Mucosa; Nicotine; Nitrosamines; Oxidative Stress; Peroxynitrous Acid; Tobacco, Smokeless; Tyrosine | 2004 |
Tyrosine 192 in apolipoprotein A-I is the major site of nitration and chlorination by myeloperoxidase, but only chlorination markedly impairs ABCA1-dependent cholesterol transport.
Topics: Amino Acid Sequence; Animals; Antioxidants; Apolipoprotein A-I; ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Chlorine; Cholesterol; Cricetinae; Electron Spin Resonance Spectroscopy; Humans; Hydrogen Peroxide; Hydrophobic and Hydrophilic Interactions; Nitrates; Nitrogen; Oxidation-Reduction; Peptides; Peroxidase; Peroxynitrous Acid; Spectrometry, Mass, Electrospray Ionization; Tyrosine | 2005 |
Tempol diverts peroxynitrite/carbon dioxide reactivity toward albumin and cells from protein-tyrosine nitration to protein-cysteine nitrosation.
Topics: Albumins; Animals; Antioxidants; Catalysis; Cyclic N-Oxides; Cysteine; Electrochemistry; Electron Spin Resonance Spectroscopy; Free Radical Scavengers; Free Radicals; Immunoblotting; Immunohistochemistry; Inflammation; Macrophages; Mice; Models, Biological; Models, Chemical; Nitric Oxide; Nitrites; Nitrogen; Oxygen; Peroxynitrous Acid; Serum Albumin, Bovine; Spin Labels; Time Factors; Tyrosine | 2005 |
Role for nitrosative stress in diabetic neuropathy: evidence from studies with a peroxynitrite decomposition catalyst.
Topics: Animals; Blood Glucose; Creatine; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetic Neuropathies; Metalloporphyrins; Mice; Mice, Inbred NOD; Neural Conduction; Neurons, Afferent; Oxidative Stress; Peroxynitrous Acid; Phosphocreatine; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Reactive Nitrogen Species; Sciatic Nerve; Tyrosine; Weight Gain | 2005 |
Oxidative stress inactivates VEGF survival signaling in retinal endothelial cells via PI 3-kinase tyrosine nitration.
Topics: Adenoviridae; Animals; Apoptosis; Blotting, Western; Caspase 3; Caspases; Cattle; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Endothelium, Vascular; Glucose; Models, Biological; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Peroxynitrous Acid; Phosphatidylinositol 3-Kinases; Phosphorylation; Precipitin Tests; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Retina; Tyrosine; Vascular Endothelial Growth Factor A | 2005 |
Phasic cardiovascular responses to mevinphos are mediated through differential activation of cGMP/PKG cascade and peroxynitrite via nitric oxide generated in the rat rostral ventrolateral medulla by NOS I and II isoforms.
Topics: Animals; Blood Pressure; Blotting, Western; Cardiovascular Physiological Phenomena; Cholinesterase Inhibitors; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Heart Rate; Male; Medulla Oblongata; Mevinphos; Microinjections; Nerve Tissue Proteins; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Rats; Spectrum Analysis; Superoxides; Time Factors; Tyrosine | 2005 |
Plasma nitrotyrosine in reversible myocardial ischaemia.
Topics: Adult; Aged; Exercise Test; Exercise Tolerance; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Peroxynitrous Acid; Tyrosine | 2005 |
A comparison between the antioxidant and peroxynitrite-scavenging functions of the vitamin E metabolites alpha- and gamma-carboxyethyl-6-hydroxychromans.
Topics: Antioxidants; Chromans; Copper; Dose-Response Relationship, Drug; Electron Spin Resonance Spectroscopy; Free Radical Scavengers; Lipid Peroxidation; Lipoproteins, LDL; Peroxynitrous Acid; Propionates; Tyrosine | 2004 |
Isoprenylhydroquinone glucoside: a new non-antioxidant inhibitor of peroxynitrite-mediated tyrosine nitration.
Topics: Asteraceae; Cytochromes c; Glucosides; Hydroquinones; Molecular Structure; Nitrates; Oxidation-Reduction; Peroxynitrous Acid; Rhodamines; Tyrosine | 2005 |
Peroxynitrite-mediated oxidation of the C85S/C152E mutant of dihydrofolate reductase from Escherichia coli: functional and structural effects.
Topics: Blotting, Western; Calorimetry, Differential Scanning; Chromatography, Gel; Chromatography, High Pressure Liquid; Cysteine; Cystine; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Immunoblotting; Mutation; Oxidative Stress; Oxygen; Peroxynitrous Acid; Reactive Oxygen Species; Spectrometry, Fluorescence; Temperature; Tetrahydrofolate Dehydrogenase; Thermodynamics; Time Factors; Tryptophan; Tyrosine | 2005 |
Antiradical activity of different copper(II) Schiff base complexes and their effect on alloxan-induced diabetes.
Topics: Animals; Antioxidants; Copper; Diabetes Mellitus, Experimental; Free Radicals; In Vitro Techniques; Male; Mice; Oxidative Stress; Peroxynitrous Acid; Schiff Bases; Superoxide Dismutase; Tyrosine | 2004 |
Oxidative injury by peroxynitrite in neural and vascular tissue of the lateral geniculate nucleus in experimental glaucoma.
Topics: Animals; Endothelium, Vascular; Geniculate Bodies; Glaucoma; Immunohistochemistry; Macaca fascicularis; Macaca mulatta; Nerve Degeneration; Neurons; Oxidative Stress; Peroxynitrous Acid; Tyrosine | 2005 |
Tyrosine nitration on p65: a novel mechanism to rapidly inactivate nuclear factor-kappaB.
Topics: Animals; Cell Line; Chlorocebus aethiops; Chromatography, Liquid; COS Cells; Deferoxamine; Humans; Mice; NF-kappa B; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Peroxynitrous Acid; Promoter Regions, Genetic; Spectrometry, Mass, Electrospray Ionization; Transcription Factor RelA; Tyrosine | 2005 |
Biochemical properties of new synthetic carnosine analogues containing the residue of 2,3-diaminopropionic acid: the effect of N-acetylation.
Topics: Acetylation; Antioxidants; beta-Alanine; Biochemistry; Carnosine; Dipeptidases; Drug Evaluation, Preclinical; Enzyme Inhibitors; Free Radical Scavengers; Humans; Hydrolysis; Hydroxyl Radical; Molecular Mimicry; Peroxynitrous Acid; Structure-Activity Relationship; Tyrosine | 2005 |
Peroxynitrite and fibrinolytic system: the effect of peroxynitrite on plasmin activity.
Topics: Blotting, Western; Chromatography, Affinity; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Fibrinogen; Fibrinolysin; Glutathione; Inhibitory Concentration 50; Oxidants; Peroxynitrous Acid; Plasminogen; Spectrophotometry; Streptokinase; Time Factors; Tyrosine | 2004 |
Site-specific nitration and oxidative dityrosine bridging of the tau protein by peroxynitrite: implications for Alzheimer's disease.
Topics: Alzheimer Disease; Amino Acid Sequence; Cross-Linking Reagents; Electrophoresis, Polyacrylamide Gel; Light; Molecular Sequence Data; Mutagenesis, Site-Directed; Nitrates; Oxidation-Reduction; Peroxynitrous Acid; Phosphorylation; Protein Processing, Post-Translational; Scattering, Radiation; Sodium Dodecyl Sulfate; tau Proteins; Tyrosine | 2005 |
Facilitated nitration and oxidation of LDL in cigarette smokers.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adult; Biomarkers; Chromatography, High Pressure Liquid; Female; Guanine; Humans; Lipoproteins, LDL; Male; Oxidation-Reduction; Oxidative Stress; Peroxynitrous Acid; Smoking; Thiobarbituric Acid Reactive Substances; Tyrosine; Vitamin E | 2005 |
Irradiation of the rabbit cornea with UVB rays stimulates the expression of nitric oxide synthases-generated nitric oxide and the formation of cytotoxic nitrogen-related oxidants.
Topics: Animals; Aqueous Humor; Cornea; Immunohistochemistry; Lipid Peroxidation; Malondialdehyde; Nerve Tissue Proteins; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Peroxynitrous Acid; Rabbits; Reactive Nitrogen Species; Tyrosine; Ultraviolet Rays | 2005 |
Glycyrrhizae Radix attenuates peroxynitrite-induced renal oxidative damage through inhibition of protein nitration.
Topics: Animals; Blood Urea Nitrogen; Chromium; Free Radical Scavengers; Glycyrrhiza; Kidney; Male; Mitochondria; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Oxidative Stress; Peroxidase; Peroxynitrous Acid; Plant Extracts; Rats; Rats, Wistar; Reactive Oxygen Species; Tyrosine | 2005 |
Role of reactive radicals in degeneration of the auditory system of mice following cisplatin treatment.
Topics: Aldehydes; Animals; Antineoplastic Agents; Cisplatin; Cochlea; Free Radicals; Hair Cells, Auditory, Outer; Hydroxyl Radical; Immunohistochemistry; Lipid Peroxidation; Mice; Mice, Inbred C57BL; Peroxynitrous Acid; Spiral Ganglion; Tyrosine | 2004 |
Immunohistochemical detection and Western blot analysis of nitrated protein in stored human corneal epithelium.
Topics: Adult; Blotting, Western; Epithelial Cells; Epithelium, Corneal; Eye Proteins; Humans; Immunohistochemistry; Middle Aged; Nitric Oxide; Oxidants; Peroxynitrous Acid; Tissue Culture Techniques; Tyrosine | 2005 |
Protective mechanisms of a metalloporphyrinic peroxynitrite decomposition catalyst, WW85, in rat cardiac transplants.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Apoptosis; Catalysis; Cyclosporine; Gene Expression; Graft Rejection; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Malondialdehyde; Metalloporphyrins; Myocardium; Neutrophils; Peroxidase; Peroxynitrous Acid; Poly Adenosine Diphosphate Ribose; Rats; Rats, Inbred Lew; Rats, Wistar; Tyrosine | 2005 |
Immunohistochemical localization of 3-nitrotyrosine in the nasal respiratory mucosa of patients with vasomotor rhinitis.
Topics: Adult; Cavernous Sinus; Female; Humans; Immunohistochemistry; Male; Muscle, Smooth; Nitric Oxide; Peroxynitrous Acid; Respiratory Mucosa; Rhinitis, Vasomotor; Rhinomanometry; Tyrosine | 2005 |
Comparison of spectrophotometric, HPLC and chemiluminescence methods for 3-nitrotyrosine and peroxynitrite interaction.
Topics: Chromatography, High Pressure Liquid; Hypochlorous Acid; Luminescent Measurements; Peroxynitrous Acid; Spectrophotometry, Ultraviolet; Tyrosine | 2005 |
Mitochondrial damage mediates genotoxicity of arsenic in mammalian cells.
Topics: Animals; Arsenites; CHO Cells; Cricetinae; DNA Damage; DNA, Mitochondrial; Humans; Hybrid Cells; Intracellular Membranes; Membrane Potentials; Mitochondria; Mutagenicity Tests; Peroxynitrous Acid; Proteins; Reactive Oxygen Species; Sodium Compounds; Tyrosine | 2005 |
Peroxynitrite modulates release of inflammatory mediators from guinea pig lung mast cells activated by antigen-antibody reaction.
Topics: Animals; Antigen-Antibody Reactions; Antioxidants; Calcium; Female; Guinea Pigs; Histamine Release; Leukotrienes; Lung; Mast Cells; Nitric Oxide; Peroxynitrous Acid; Phospholipases A; Reactive Oxygen Species; Tyrosine | 2005 |
Ilex paraguariensis extracts are potent inhibitors of nitrosative stress: a comparative study with green tea and wines using a protein nitration model and mammalian cell cytotoxicity.
Topics: Animals; Beverages; Camellia sinensis; Cattle; Cell Line; Cell Shape; Cell Survival; Drug Evaluation, Preclinical; Flavonoids; Free Radical Scavengers; Humans; Ilex paraguariensis; Macrophages; Mice; Peroxynitrous Acid; Phenols; Plant Extracts; Polyphenols; Serum Albumin, Bovine; Tea; Tyrosine; Wine | 2005 |
The effects of nitric oxide synthesis on the Na+ ,K(+)-ATPase activity in guinea pig kidney exposed to lipopolysaccharides.
Topics: Animals; Free Radicals; Guinea Pigs; Kidney; Lipopolysaccharides; Nephritis; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Reactive Nitrogen Species; Regression Analysis; Sodium-Potassium-Exchanging ATPase; Tyrosine | 2005 |
15-Deoxy-Delta12,14-prostaglandin J2 and peroxisome proliferator-activated receptor gamma (PPARgamma) levels in term placental tissues from control and diabetic rats: modulatory effects of a PPARgamma agonist on nitridergic and lipid placental metabolism.
Topics: Acetates; Animals; Blood Glucose; Case-Control Studies; Diabetes Mellitus, Experimental; Female; Gestational Age; Lipid Metabolism; Nitrates; Nitrites; Peroxynitrous Acid; Placenta; PPAR gamma; Pregnancy; Prostaglandin D2; Rats; Rats, Wistar; Streptozocin; Tyrosine | 2005 |
Cleavage of alpha-synuclein by calpain: potential role in degradation of fibrillized and nitrated species of alpha-synuclein.
Topics: alpha-Synuclein; Calpain; Chymotrypsin; Humans; Hydrolysis; Microscopy, Immunoelectron; Nerve Degeneration; Nerve Tissue Proteins; Nitrates; Parkinson Disease; Peptide Fragments; Peroxynitrous Acid; Recombinant Proteins; Solubility; Synucleins; Tyrosine | 2005 |
Probing the hydroxyl radical-mediated reactivity of peroxynitrite by a spin-labeling fluorophore.
Topics: Carbon Dioxide; Chromatography, High Pressure Liquid; Dimethyl Sulfoxide; Fluorescent Dyes; Formates; Histidine; Hydrogen-Ion Concentration; Hydroxyl Radical; Indicators and Reagents; Peroxynitrous Acid; Phenylalanine; Reproducibility of Results; Solvents; Spectrometry, Fluorescence; Spin Labels; Tyrosine | 2005 |
Protein phosphatase 1alpha is tyrosine-phosphorylated and inactivated by peroxynitrite in erythrocytes through the src family kinase fgr.
Topics: Down-Regulation; Enzyme Activation; Erythrocytes; Humans; K Cl- Cotransporters; Molsidomine; Peroxynitrous Acid; Phosphoprotein Phosphatases; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-hck; src-Family Kinases; Symporters; Tyrosine | 2005 |
Time course and site(s) of cytochrome c tyrosine nitration by peroxynitrite.
Topics: Amino Acid Sequence; Animals; Cytochromes c; Electron Transport; Horses; Mitochondria, Heart; Molecular Sequence Data; Peroxidase; Peroxynitrous Acid; Potassium Cyanide; Rats; Sodium Cyanide; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tetranitromethane; Time Factors; Tyrosine | 2005 |
In vitro activity of the essential oil of Cinnamomum zeylanicum and eugenol in peroxynitrite-induced oxidative processes.
Topics: Animals; Chromatography, High Pressure Liquid; Cinnamomum zeylanicum; Eugenol; Lipid Peroxidation; Microsomes, Liver; Nitrates; Oils, Volatile; Oxidation-Reduction; Peroxynitrous Acid; Rats; Tyrosine | 2005 |
Peroxynitrite like Pan?
Topics: Biomarkers; Cells, Cultured; Heart Failure; Humans; Myocardial Contraction; Myocardial Reperfusion Injury; Myocardium; Peroxynitrous Acid; Tyrosine | 2005 |
Protective effect of trapidil against oxidative organ damage in burn injury.
Topics: Animals; Burns; Lipid Peroxidation; Malondialdehyde; Oxidative Stress; Peroxidase; Peroxynitrous Acid; Protective Agents; Random Allocation; Rats; Rats, Wistar; Trapidil; Tumor Necrosis Factor-alpha; Tyrosine | 2005 |
Peroxynitrite-derived carbonate and nitrogen dioxide radicals readily react with lipoic and dihydrolipoic acid.
Topics: Antioxidants; Carbonates; Chromatography, High Pressure Liquid; Computer Simulation; Dimerization; Dose-Response Relationship, Drug; Free Radicals; Kinetics; Liposomes; Nitric Oxide; Nitrogen Dioxide; Oxygen; Peroxynitrous Acid; Sulfhydryl Compounds; Temperature; Thioctic Acid; Tyrosine | 2005 |
Essential oils of commonly used plants as inhibitors of peroxynitrite-induced tyrosine nitration.
Topics: Humans; Laurus; Nitrates; Peroxynitrous Acid; Phytotherapy; Plant Leaves; Plant Oils; Tyrosine | 2005 |
Local peroxynitrite formation contributes to early control of Cryptosporidium parvum infection.
Topics: Animals; Cryptosporidiosis; Cryptosporidium parvum; Female; Immunohistochemistry; Lipid Peroxidation; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Swine; Tyrosine | 2005 |
Early administration of a second-generation perfluorochemical decreases ischemic brain damage in a model of permanent middle cerebral artery occlusion in the rat.
Topics: Analysis of Variance; Animals; Blood Gas Analysis; Brain Ischemia; Cerebrovascular Circulation; Disease Models, Animal; Drug Therapy, Combination; Fluorocarbons; Immunohistochemistry; Infarction, Middle Cerebral Artery; Laser-Doppler Flowmetry; Male; Necrosis; Neuroprotective Agents; Oxygen; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Silver Staining; Time Factors; Tyrosine | 2005 |
Photoreceptor mitochondrial tyrosine nitration in experimental uveitis.
Topics: Amino Acid Sequence; Animals; Autoimmune Diseases; Blotting, Western; Cytochromes c; Disease Models, Animal; Immunoenzyme Techniques; Mass Spectrometry; Mitochondrial Proteins; Molecular Chaperones; Molecular Sequence Data; Nitrosation; Peroxynitrous Acid; Phosphoglycerate Mutase; Photoreceptor Cells, Vertebrate; Rats; Rats, Inbred Lew; Retina; Spectrophotometry, Ultraviolet; Tyrosine; Uveitis | 2005 |
Peroxynitrite-induced alpha-actinin nitration and contractile alterations in isolated human myocardial cells.
Topics: Actinin; Blotting, Western; Calcium; Cells, Cultured; Depression, Chemical; Dose-Response Relationship, Drug; Heart Ventricles; Humans; Immunoblotting; Myocardial Contraction; Myocytes, Cardiac; Peroxynitrous Acid; Tyrosine | 2005 |
Effect of nitration on protein tyrosine phosphatase and protein phosphatase activity in neuronal cell membranes of newborn piglets.
Topics: Animals; Animals, Newborn; Cell Membrane; Cerebral Cortex; Enzyme Inhibitors; Hypoxia, Brain; In Vitro Techniques; Neurons; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Peroxynitrous Acid; Protein Tyrosine Phosphatases; Tyrosine | 2005 |
Biochemical properties of cytochrome c nitrated by peroxynitrite.
Topics: Animals; Cyanides; Cytochromes c; Enzyme Stability; Fluoresceins; Oxidation-Reduction; Peroxidases; Peroxynitrous Acid; Protein Denaturation; Protein Folding; Superoxides; Tyrosine | 2006 |
The highly conserved Glu149 and Tyr190 residues contribute to peroxynitrite-mediated nitrotyrosine formation and the catalytic activity of cytochrome P450 2B1.
Topics: Catalysis; Conserved Sequence; Cytochrome P-450 CYP2B1; Escherichia coli; Glutamine; Heme; Hydrogen Bonding; Iron; Kinetics; Models, Molecular; Molecular Sequence Data; Oxidoreductases; Peroxynitrous Acid; Plasmids; Temperature; Tyrosine | 2005 |
Tyrosine nitration by superoxide and nitric oxide fluxes in biological systems: modeling the impact of superoxide dismutase and nitric oxide diffusion.
Topics: Catalysis; Computer Simulation; Diffusion; Dose-Response Relationship, Drug; Glutathione; Kinetics; Models, Biological; Nitric Oxide; Nitrogen; Oxygen; Peroxynitrous Acid; Superoxide Dismutase; Superoxides; Tyrosine | 2005 |
Excitotoxic brain damage involves early peroxynitrite formation in a model of Huntington's disease in rats: protective role of iron porphyrinate 5,10,15,20-tetrakis (4-sulfonatophenyl)porphyrinate iron (III).
Topics: Analysis of Variance; Animals; Behavior, Animal; Blotting, Southern; Brain Injuries; Caspase 3; Caspases; Chromatography, High Pressure Liquid; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electrophoresis, Agar Gel; gamma-Aminobutyric Acid; Huntington Disease; Lipid Peroxidation; Male; Mitochondria; Motor Activity; Nitric Oxide Synthase; Peroxynitrous Acid; Porphyrins; Quinolinic Acids; Radiation-Sensitizing Agents; Rats; Rats, Wistar; Rotarod Performance Test; Superoxide Dismutase; Synaptic Vesicles; Synaptosomes; Tyrosine | 2005 |
Protective effects of resveratrol against oxidative/nitrative modifications of plasma proteins and lipids exposed to peroxynitrite.
Topics: Blood Proteins; Deferoxamine; Humans; Lipid Peroxidation; Lipids; Oxidation-Reduction; Peroxynitrous Acid; Resveratrol; Stilbenes; Tyrosine | 2006 |
Sites and mechanisms of aconitase inactivation by peroxynitrite: modulation by citrate and glutathione.
Topics: Aconitate Hydratase; Amino Acid Sequence; Amino Acids; Animals; Citric Acid; Cysteine; Enzyme Activation; Glutathione; Mass Spectrometry; Molecular Sequence Data; Myocardium; Peroxynitrous Acid; Swine; Tyrosine | 2005 |
Zingerone as an antioxidant against peroxynitrite.
Topics: Antioxidants; Free Radical Scavengers; Guaiacol; Peroxynitrous Acid; Serum Albumin, Bovine; Tyrosine | 2005 |
Peroxynitrite reduces the endothelium-derived hyperpolarizing factor component of coronary flow-mediated dilation in PECAM-1-knockout mice.
Topics: Animals; Azoles; Biological Factors; Coronary Vessels; Gene Deletion; Hydrogen Peroxide; Indomethacin; Isoindoles; Male; Mice; Mice, Knockout; NG-Nitroarginine Methyl Ester; Nitric Oxide; Organoselenium Compounds; Peroxynitrous Acid; Platelet Endothelial Cell Adhesion Molecule-1; Prostaglandins; Tyrosine; Vasodilation | 2006 |
Immunochemical detection of nitric oxide and nitrogen dioxide trapping of the tyrosyl radical and the resulting nitrotyrosine in sperm whale myoglobin.
Topics: Aerobiosis; Animals; Blotting, Western; Cyclic N-Oxides; Free Radicals; Immune Sera; Immunochemistry; Myoglobin; Nitric Oxide; Nitrogen Dioxide; Nitrogen Oxides; Oxygen; Partial Pressure; Peroxynitrous Acid; Sperm Whale; Spin Trapping; Tyrosine | 2005 |
Post-translational modification of manganese superoxide dismutase in acutely rejecting cardiac transplants: role of inducible nitric oxide synthase.
Topics: Acute Disease; Animals; Disease Models, Animal; Enzyme Inhibitors; Gene Expression; Graft Rejection; Heart Transplantation; Lysine; Nitric Oxide Synthase Type II; Oxidative Stress; Peroxynitrous Acid; Protein Processing, Post-Translational; Rats; Rats, Inbred Lew; Rats, Inbred WF; Superoxide Dismutase; Tyrosine | 2005 |
Peroxynitrite causes endoplasmic reticulum stress and apoptosis in human vascular endothelium: implications in atherogenesis.
Topics: Animals; Aorta; Apolipoproteins E; Apoptosis; Atherosclerosis; Calcium; Cells, Cultured; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Endothelium, Vascular; Female; Homeostasis; Humans; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Oxidative Stress; Peroxynitrous Acid; Superoxides; Tyrosine; Umbilical Veins | 2005 |
Inorganic arsenic compounds cause oxidative damage to DNA and protein by inducing ROS and RNS generation in human keratinocytes.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Arsenates; Arsenites; Cell Line; Chromatography, High Pressure Liquid; Deoxyguanosine; DNA Damage; Dose-Response Relationship, Drug; Enzyme Inhibitors; Free Radical Scavengers; Humans; Keratinocytes; Metalloporphyrins; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Peroxynitrous Acid; Reactive Nitrogen Species; Reactive Oxygen Species; Sodium Compounds; Superoxide Dismutase; Time Factors; Tyrosine | 2005 |
Peroxynitrite mediates TNF-alpha-induced endothelial barrier dysfunction and nitration of actin.
Topics: Actins; Albumins; Animals; Capillary Permeability; Cattle; Cells, Cultured; Endothelial Cells; Endothelium, Vascular; Lung; Microcirculation; Nitrates; Peroxynitrous Acid; Protein Isoforms; Rats; Tissue Distribution; Tumor Necrosis Factor-alpha; Tyrosine; Uric Acid | 2006 |
Inhibition of tyrosine-kinase-mediated cellular signaling by tyrphostins AG 126 and AG556 modulates murine experimental acute pancreatitis.
Topics: Acute Disease; Amylases; Animals; Enzyme Inhibitors; Lipase; Lipid Peroxidation; Male; Mice; Mice, Inbred Strains; Neutrophils; Nitric Oxide; Pancreas; Pancreatitis; Peroxynitrous Acid; Poly(ADP-ribose) Polymerases; Protein-Tyrosine Kinases; Signal Transduction; Tumor Necrosis Factor-alpha; Tyrosine; Tyrphostins | 2005 |
Nitration of tyrosine 92 mediates the activation of rat microsomal glutathione s-transferase by peroxynitrite.
Topics: Amino Acid Sequence; Animals; Binding Sites; Glutathione Transferase; Hydrogen Peroxide; Liver; LLC-PK1 Cells; Mass Spectrometry; Methionine; Microsomes; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Nitric Oxide; Oxidants; Peroxynitrous Acid; Rats; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Swine; Transfection; Trypsin; Tyrosine | 2006 |
Abnormal development and increased 3-nitrotyrosine in copper-deficient mouse embryos.
Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; 8-Hydroxy-2'-Deoxyguanosine; Aldehydes; Animals; Brain; Copper; Deoxyguanosine; DNA Damage; Epithelium; Female; Fetal Development; Glutathione Peroxidase; Growth Inhibitors; Heart Defects, Congenital; Indicators and Reagents; Lipids; Mice; Neural Tube Defects; Peroxynitrous Acid; Pregnancy; Superoxide Dismutase; Superoxides; Tyrosine | 2006 |
Nitration and inactivation of IDO by peroxynitrite.
Topics: Amino Acid Sequence; Blotting, Western; Cell Line, Tumor; Chromatography, High Pressure Liquid; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Leukocytes, Mononuclear; Molecular Sequence Data; Mutagenesis, Site-Directed; Peroxynitrous Acid; Spectrometry, Mass, Electrospray Ionization; Tyrosine | 2006 |
3-Nitrotyrosine-dependent dopaminergic neurotoxicity following direct nigral administration of a peroxynitrite but not a nitric oxide donor.
Topics: Animals; Corpus Striatum; Dopamine; Male; Neurons; Neurotoxins; Nitric Oxide Donors; Peroxynitrous Acid; Rats; Rats, Wistar; Substantia Nigra; Tyrosine | 2006 |
Detection of sequence-specific tyrosine nitration of manganese SOD and SERCA in cardiovascular disease and aging.
Topics: Aging; Animals; Calcium-Transporting ATPases; Cardiovascular Diseases; Dithionite; Immunoblotting; Immunohistochemistry; In Vitro Techniques; Kidney; Oxidative Stress; Peroxynitrous Acid; Rabbits; Sarcoplasmic Reticulum; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Superoxide Dismutase; Tyrosine | 2006 |
Mode of action of poly(vinylpyridine-N-oxide) in preventing silicosis: effective scavenging of carbonate anion radical.
Topics: Bicarbonates; Free Radical Scavengers; Humans; Hydrogen-Ion Concentration; Hydroxyl Radical; Kinetics; Peroxynitrous Acid; Polyvinylpyridine N-Oxide; Quartz; Reactive Oxygen Species; Silicosis; Tyrosine | 2006 |
Nitration of profilin effects its interaction with poly (L-proline) and actin.
Topics: Actins; Animals; Cattle; Nitrates; Peptides; Peroxynitrous Acid; Profilins; Spleen; Tyrosine | 2005 |
Crystal structure of nitrated human manganese superoxide dismutase: mechanism of inactivation.
Topics: Binding Sites; Catalysis; Crystallization; Crystallography, X-Ray; Humans; Hydrogen Bonding; Manganese; Models, Molecular; Peroxynitrous Acid; Protein Conformation; Superoxide Dismutase; Tyrosine | 2006 |
The role of peroxynitrite in chemical preconditioning with 3-nitropropionic acid in rat hearts.
Topics: Animals; Biomarkers; Ischemic Preconditioning, Myocardial; L-Lactate Dehydrogenase; Male; Myocardial Reperfusion Injury; Myocardium; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase; Nitro Compounds; Peroxynitrous Acid; Propionates; Rats; Rats, Wistar; Succinate Dehydrogenase; Superoxide Dismutase; Tyrosine; Xanthine Oxidase | 2006 |
Peroxynitrite diminishes myogenic activity and is associated with decreased vascular smooth muscle F-actin in rat posterior cerebral arteries.
Topics: Actins; Animals; Blood Pressure; Brain; Cerebral Arteries; Humans; Infarction, Middle Cerebral Artery; Ischemia; Male; Microscopy, Confocal; Muscle, Smooth, Vascular; Peroxynitrous Acid; Posterior Cerebral Artery; Rats; Rats, Wistar; Reactive Oxygen Species; Reperfusion Injury; Time Factors; Tyrosine | 2006 |
Heme catalyzes tyrosine 385 nitration and inactivation of prostaglandin H2 synthase-1 by peroxynitrite.
Topics: Amino Acid Sequence; Animals; Apoenzymes; Binding Sites; Catalysis; Chromatography, Ion Exchange; Cyclooxygenase 1; Electrophoresis, Polyacrylamide Gel; Free Radical Scavengers; Heme; Hemin; Holoenzymes; Hydroxyl Radical; Male; Models, Chemical; Molecular Sequence Data; Molsidomine; Peroxynitrous Acid; Seminal Vesicles; Sheep; Tyrosine | 2006 |
Peroxynitrite induces F-actin depolymerization and blockade of myosin ATPase stimulation.
Topics: Actins; Animals; Calorimetry, Differential Scanning; Enzyme Activation; Molsidomine; Myosins; Oxidation-Reduction; Peroxynitrous Acid; Protein Denaturation; Protein Folding; Rabbits; Temperature; Tyrosine | 2006 |
Detection of specific nitrotyrosine-modified proteins as a marker of oxidative stress in cardiovascular disease.
Topics: Aerobiosis; Animals; Biomarkers; Calcium-Transporting ATPases; Cardiovascular Diseases; Humans; Oxidative Stress; Peroxynitrous Acid; Protein Processing, Post-Translational; Proteins; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Superoxide Dismutase; Tyrosine | 2006 |
Peroxynitrite: just an oxidative/nitrosative stressor or a physiological regulator as well?
Topics: Animals; Humans; Oxidative Stress; Peroxynitrous Acid; Signal Transduction; Tyrosine | 2006 |
Are oxidative mechanisms primary in ethanol induced Purkinje neuron death of the neonatal rat?
Topics: Acetylcysteine; Animals; Animals, Newborn; Cell Count; Cell Death; Cerebellum; Drug Interactions; Enzyme-Linked Immunosorbent Assay; Female; Free Radical Scavengers; Male; Peroxynitrous Acid; Pregnancy; Purkinje Cells; Rats; Rats, Sprague-Dawley; Time Factors; Tyrosine | 2006 |
Identification of ubiquitin nitration and oxidation using a liquid chromatography/mass selective detector system.
Topics: Biotechnology; Chromatography, Liquid; Mass Spectrometry; Methionine; Nitrates; Oxidants; Oxidation-Reduction; Peroxynitrous Acid; Spectrometry, Mass, Electrospray Ionization; Trypsin; Tyrosine; Ubiquitin | 2005 |
Inhibition of skeletal muscle S1-myosin ATPase by peroxynitrite.
Topics: Actins; Adenosine Diphosphate; Adenosine Triphosphatases; Animals; Catalysis; Cysteine; Dose-Response Relationship, Drug; Enzyme Stability; Magnesium; Molsidomine; Myosin Subfragments; Oxidation-Reduction; Peroxynitrous Acid; Protein Folding; Rabbits; Skeletal Muscle Myosins; Temperature; Time Factors; Tyrosine | 2006 |
Time course of post-traumatic mitochondrial oxidative damage and dysfunction in a mouse model of focal traumatic brain injury: implications for neuroprotective therapy.
Topics: Animals; Blotting, Northern; Brain Hemorrhage, Traumatic; Calpain; Cytoskeleton; Male; Membrane Lipids; Membrane Proteins; Mice; Microscopy, Electron; Mitochondria; Nerve Degeneration; Neuroprotective Agents; Oxidative Stress; Oxygen Consumption; Peroxynitrous Acid; Reactive Oxygen Species; Tyrosine | 2006 |
Combined burn and smoke inhalation injury impairs ovine hypoxic pulmonary vasoconstriction.
Topics: Animals; Burns; Female; Hypoxia; Lung; Multiple Trauma; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Pulmonary Gas Exchange; Random Allocation; Respiratory Distress Syndrome; Sheep; Single-Blind Method; Smoke Inhalation Injury; Survival Analysis; Tyrosine; Vasoconstriction | 2006 |
Nordihydroguaiaretic acid is a potent in vitro scavenger of peroxynitrite, singlet oxygen, hydroxyl radical, superoxide anion and hypochlorous acid and prevents in vivo ozone-induced tyrosine nitration in lungs.
Topics: Animals; Antioxidants; Dose-Response Relationship, Drug; Free Radical Scavengers; Hydroxyl Radical; Hypochlorous Acid; Immunohistochemistry; Lung; Male; Masoprocol; Ozone; Peroxynitrous Acid; Rats; Rats, Wistar; Reactive Oxygen Species; Singlet Oxygen; Superoxides; Tyrosine | 2006 |
Peroxynitrite generation and tyrosine nitration in defense responses in tobacco BY-2 cells.
Topics: Algal Proteins; Aniline Compounds; Antibodies, Anti-Idiotypic; Cells, Cultured; Cyclic GMP; Fluoresceins; Fungal Proteins; Molsidomine; Nicotiana; Nitric Oxide; Peroxynitrous Acid; Phytophthora; Proteins; Reactive Oxygen Species; Superoxides; Tyrosine; Uric Acid | 2006 |
Peroxynitrite-mediated tau modifications stabilize preformed filaments and destabilize microtubules through distinct mechanisms.
Topics: Amino Acid Sequence; Microtubules; Neurofibrillary Tangles; Peroxynitrous Acid; Protein Structure, Quaternary; tau Proteins; Tyrosine | 2006 |
The production of peroxynitrite by human spermatozoa may affect sperm motility through the formation of protein nitrotyrosine.
Topics: Adult; Humans; Infertility, Male; Male; Peroxynitrous Acid; Sperm Motility; Spermatozoa; Tyrosine | 2006 |
Age-associated tyrosine nitration of rat skeletal muscle glycogen phosphorylase b: characterization by HPLC-nanoelectrospray-tandem mass spectrometry.
Topics: Aging; Animals; Base Sequence; Chromatography, High Pressure Liquid; Glycogen Phosphorylase, Muscle Form; Longevity; Molecular Sequence Data; Muscle, Skeletal; Peroxynitrous Acid; Rats; Rats, Inbred BN; Rats, Inbred F344; Sequence Alignment; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Tyrosine | 2006 |
Glutathione reverses peroxynitrite-mediated deleterious effects of nitroglycerin on ischemic rat hearts.
Topics: Animals; Apoptosis; Glutathione; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocytes, Cardiac; Nitroglycerin; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Tyrosine | 2006 |
Double null of selenium-glutathione peroxidase-1 and copper, zinc-superoxide dismutase enhances resistance of mouse primary hepatocytes to acetaminophen toxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Benzoquinones; Cell Death; Cells, Cultured; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Hepatocytes; Imines; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide; Peroxynitrous Acid; Superoxide Dismutase; Tyrosine | 2006 |
Cabergoline scavenges peroxynitrite enhanced by L-DOPA therapy in patients with Parkinson's disease.
Topics: Aged; Antiparkinson Agents; Cabergoline; Chromatography, High Pressure Liquid; Ergolines; Female; Free Radical Scavengers; Humans; Levodopa; Male; Oxidative Stress; Parkinson Disease; Peroxynitrous Acid; Tyrosine | 2006 |
Effect of lycopene and beta-carotene on peroxynitrite-mediated cellular modifications.
Topics: Animals; Antioxidants; beta Carotene; Carotenoids; Cell Line; Cell Survival; Comet Assay; Cricetinae; Cricetulus; DNA Damage; Lycopene; Molsidomine; Nitric Oxide Donors; Peroxynitrous Acid; Tyrosine | 2006 |
Mechanistic studies of peroxynitrite-mediated tyrosine nitration in membranes using the hydrophobic probe N-t-BOC-L-tyrosine tert-butyl ester.
Topics: Carbon Dioxide; Chromatography, High Pressure Liquid; Dimerization; Fatty Acids, Unsaturated; Hydrophobic and Hydrophilic Interactions; Lipid Bilayers; Liposomes; Membranes; Molecular Probes; Nitrogen; Oxidation-Reduction; Peroxynitrous Acid; Phosphatidylcholines; Spectrum Analysis; Tyrosine | 2006 |
The effects of chronic exposure to ethanol and cigarette smoke on the formation of peroxynitrite, level of nitric oxide, xanthine oxidase and myeloperoxidase activities in rat kidney.
Topics: Animals; Epithelial Cells; Ethanol; Immunohistochemistry; Inhalation Exposure; Kidney; Kidney Glomerulus; Kidney Tubules, Proximal; Leukocytes, Mononuclear; Male; Nitric Oxide; Peroxidase; Peroxynitrous Acid; Rats; Rats, Wistar; Smoking; Tyrosine; Xanthine Oxidase | 2006 |
Reactive nitrogen species induce nuclear factor-kappaB-mediated protein degradation in skeletal muscle cells.
Topics: Animals; Antioxidants; Cells, Cultured; Metalloendopeptidases; Molsidomine; Muscle Cells; Muscle Fibers, Skeletal; Muscle Proteins; Muscle, Skeletal; Myosin Heavy Chains; NF-kappa B; Nitric Oxide Donors; Penicillamine; Peroxynitrous Acid; Proteasome Endopeptidase Complex; Rats; Reactive Nitrogen Species; Tyrosine; Ubiquitin | 2006 |
Modifications of platelet from Alzheimer disease patients: a possible relation between membrane properties and NO metabolites.
Topics: Aged; Alzheimer Disease; Blood Platelets; Calcium; Diphenylhexatriene; Female; Humans; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Peroxynitrous Acid; Sodium-Potassium-Exchanging ATPase; Tyrosine | 2007 |
A role for nitric oxide-mediated peroxynitrite formation in a model of endotoxin-induced shock.
Topics: Amidines; Animals; Benzylamines; Endothelium, Vascular; Liver; Male; Metalloporphyrins; Multiple Organ Failure; Nitric Oxide; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Shock, Septic; Tyrosine; Vasoconstriction | 2006 |
Tetrahydrobiopterin attenuates microvascular reperfusion injury following murine pancreas transplantation.
Topics: Animals; Biopterins; Male; Mice; Mice, Inbred C57BL; Microcirculation; Pancreas Transplantation; Peroxynitrous Acid; Reperfusion Injury; Transplantation, Homologous; Tyrosine | 2006 |
Mice deficient in Cu,Zn-superoxide dismutase are resistant to acetaminophen toxicity.
Topics: Acetaminophen; Alanine Transaminase; Animals; Benzoquinones; Biotransformation; Body Weight; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Drug Resistance; Enzyme Induction; Glutathione; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Imines; Liver Failure; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxidation-Reduction; Oxidative Stress; Peroxynitrous Acid; Superoxide Dismutase; Tyrosine | 2006 |
Manganese enhances peroxynitrite and leukotriene E4 formation in bovine aortic endothelial cells exposed to arsenic.
Topics: Animals; Aorta; Arsenic; Arsenites; Cattle; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Drug Combinations; Drug Synergism; Endothelium, Vascular; Environmental Pollutants; Enzyme Inhibitors; Leukotriene E4; Manganese; NG-Nitroarginine Methyl Ester; Peroxynitrous Acid; Sodium Compounds; Tyrosine | 2006 |
Modulation of peroxynitrite-induced fibroblast injury by hesperetin: a role for intracellular scavenging and modulation of ERK signalling.
Topics: Cells, Cultured; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Hesperidin; Humans; Molsidomine; Nitric Oxide Donors; Peroxynitrous Acid; Signal Transduction; Tyrosine | 2006 |
Peroxynitrite treatment in vitro disables catalytic activity of recombinant p38 MAPK.
Topics: Amino Acid Sequence; Catalysis; Mass Spectrometry; Models, Molecular; Molecular Sequence Data; Nitrates; p38 Mitogen-Activated Protein Kinases; Peroxynitrous Acid; Protein Isoforms; Protein Structure, Tertiary; Recombinant Proteins; Tyrosine | 2006 |
Thioredoxin reduces post-ischemic myocardial apoptosis by reducing oxidative/nitrative stress.
Topics: Animals; Apoptosis; Male; Mice; Molsidomine; Myocardial Ischemia; Myocardium; Myocytes, Cardiac; Nitric Oxide; Oxidative Stress; Peroxynitrous Acid; Superoxides; Thioredoxins; Tyrosine | 2006 |
Interplay of pneumococcal hydrogen peroxide and host-derived nitric oxide.
Topics: Animals; Carbamoyl-Phosphate Synthase (Ammonia); Cells, Cultured; Disease Models, Animal; Gene Deletion; Guanidines; Humans; Hydrogen Peroxide; Meningitis, Pneumococcal; Mice; Mice, Inbred C57BL; Neuroglia; Neurons; Nitric Oxide; Nitric Oxide Synthase; Peroxynitrous Acid; Pyruvate Oxidase; Streptococcus pneumoniae; Tyrosine | 2006 |
Nitration of p38 MAPK in the placenta: association of nitration with reduced catalytic activity of p38 MAPK in pre-eclampsia.
Topics: Adult; Amino Acid Sequence; Catalysis; Female; Gestational Age; Humans; Molecular Sequence Data; Molecular Weight; Oxidation-Reduction; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Peroxynitrous Acid; Phosphorylation; Placenta; Pre-Eclampsia; Pregnancy; Protein Processing, Post-Translational; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tyrosine | 2006 |
Up-regulation of heme oxygenase provides vascular protection in an animal model of diabetes through its antioxidant and antiapoptotic effects.
Topics: Animals; Antioxidants; Apoptosis; bcl-X Protein; Blood Pressure; Blotting, Western; Diabetic Angiopathies; Endothelial Cells; Heme Oxygenase (Decyclizing); Hypertension; Male; NADPH Oxidases; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxygen; Oxygen Consumption; p38 Mitogen-Activated Protein Kinases; Peroxynitrous Acid; Phosphorylation; Rats; Rats, Zucker; Signal Transduction; Tyrosine; Up-Regulation | 2006 |
Antioxidant and antiaggregatory effects of an extract from Conyza canadensis on blood platelets in vitro.
Topics: Analysis of Variance; Antioxidants; Blood Platelets; Conyza; Humans; In Vitro Techniques; Oxidative Stress; Peroxynitrous Acid; Plant Extracts; Platelet Aggregation; Protein Carbonylation; Tyrosine | 2006 |
The antagonism of cholecystokinin octapeptide-8 to the peroxynitrite oxidation on a diabetic cataractal rat model.
Topics: Animals; Blotting, Western; Cataract; Diabetes Mellitus, Experimental; Fluorescent Antibody Technique; Male; Nitric Oxide Synthase Type II; Oxidation-Reduction; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sincalide; Streptozocin; Tyrosine | 2006 |
Superoxide radical- and peroxynitrite-scavenging activity of anthocyanins; structure-activity relationship and their synergism.
Topics: Animals; Anthocyanins; Drug Synergism; Free Radical Scavengers; Male; Molecular Structure; Peroxynitrous Acid; Rats; Rats, Wistar; Stereoisomerism; Structure-Activity Relationship; Superoxides; Tyrosine; Vaccinium myrtillus | 2006 |
Uncoupling of endothelial nitric oxidase synthase by hypochlorous acid: role of NAD(P)H oxidase-derived superoxide and peroxynitrite.
Topics: Animals; Atherosclerosis; Cells, Cultured; Endothelium, Vascular; Female; Humans; Hypochlorous Acid; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; NADPH Oxidase 2; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidants; Oxygen; Peroxidase; Peroxynitrous Acid; Phosphoproteins; Superoxides; Tyrosine; Uncoupling Agents | 2006 |
Peroxynitrite diminishes myogenic tone in cerebral arteries: role of nitrotyrosine and F-actin.
Topics: Actins; Animals; Dithiothreitol; Dose-Response Relationship, Drug; Glyburide; Immunohistochemistry; In Vitro Techniques; Male; Microscopy, Confocal; Oxidation-Reduction; Peroxynitrous Acid; Posterior Cerebral Artery; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Wistar; Sulfhydryl Compounds; Tetraethylammonium; Time Factors; Tyrosine; Vasodilation | 2007 |
Superoxide, peroxynitrite and oxidative/nitrative stress in inflammation.
Topics: Anti-Inflammatory Agents; Humans; Inflammation; Oxidative Stress; Peroxynitrous Acid; Reactive Oxygen Species; Superoxides; Tyrosine | 2006 |
Identification of the nitration site of insulin by peroxynitrite.
Topics: Amino Acid Sequence; Chromatography, High Pressure Liquid; Insulin; Insulin, Lente; Insulin, Long-Acting; Insulin, Regular, Pork; Peroxynitrous Acid; Serine Endopeptidases; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tyrosine | 2007 |
Cerebrovascular nitrosative stress mediates neurovascular and endothelial dysfunction induced by angiotensin II.
Topics: Acetylcholine; Adenosine; Angiotensin II; Animals; Cerebrovascular Circulation; Endothelium, Vascular; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrosation; Peroxynitrous Acid; Reactive Oxygen Species; Superoxides; Tyrosine; Vasodilator Agents; Vibrissae | 2007 |
Peroxynitrite transforms nerve growth factor into an apoptotic factor for motor neurons.
Topics: Animals; Apoptosis; Blotting, Western; Cells, Cultured; Electrophoretic Mobility Shift Assay; Mass Spectrometry; Motor Neurons; Nerve Growth Factor; Oligonucleotides, Antisense; Peroxynitrous Acid; Rats; Reactive Nitrogen Species; Reactive Oxygen Species; Receptor, Nerve Growth Factor; Tyrosine | 2006 |
Time-dependent expression pattern of nitric oxide and superoxide after myocardial infarction in rats.
Topics: Animals; Enzyme Activation; Immunohistochemistry; Kinetics; Male; Myocardial Infarction; Myocardium; NADH, NADPH Oxidoreductases; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Peroxynitrous Acid; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Superoxides; Time Factors; Tyrosine | 2007 |
Modulation of protein tyrosine nitration and inflammatory mediators by isoprenylhydroquinone glucoside.
Topics: 3T3 Cells; Animals; Blotting, Western; Cell Survival; Cell-Free System; Cells, Cultured; Fibroblasts; Glucosides; Heme; Humans; Hydrogen Peroxide; Hydroquinones; Inflammation Mediators; Interleukin-1beta; Lipopolysaccharides; Mice; Neutrophils; Nitrates; Nitric Oxide Synthase Type II; Nitrites; Peroxynitrous Acid; Reverse Transcriptase Polymerase Chain Reaction; Rhodamines; Serum Albumin, Bovine; Stimulation, Chemical; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Tyrosine | 2007 |
Neutrophils-derived peroxynitrite contributes to acute hyperalgesia and cell influx in zymosan arthritis.
Topics: Acute Disease; Animals; Arthritis, Experimental; Hindlimb; Hyperalgesia; Injections, Intra-Articular; Knee Joint; Male; Neutrophils; Nitric Oxide; Peroxidase; Peroxynitrous Acid; Rats; Rats, Wistar; Reactive Nitrogen Species; Synovial Fluid; Tyrosine; Uric Acid; Zymosan | 2007 |
Puerarin decreases lens epithelium cell apoptosis induced partly by peroxynitrite in diabetic rats.
Topics: Animals; Apoptosis; Cataract; Diabetes Mellitus, Experimental; Epithelial Cells; Isoflavones; Lens, Crystalline; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Rats; Tyrosine | 2006 |
Reversible inhibition of mammalian glutamine synthetase by tyrosine nitration.
Topics: Animals; Enzyme Activation; Glutamate-Ammonia Ligase; Nitrates; Oxidative Stress; Peroxynitrous Acid; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Sheep; Tyrosine | 2007 |
Role of peroxynitrite in secondary oxidative damage after spinal cord injury.
Topics: Aldehydes; Animals; Biomarkers; Calcium Signaling; Calpain; Disease Progression; Female; Free Radical Scavengers; Free Radicals; Lipid Peroxidation; Nerve Degeneration; Nitric Oxide; Oxidative Stress; Peptide Fragments; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Spectrin; Spinal Cord Injuries; Time Factors; Tyrosine; Up-Regulation | 2007 |
Enalapril improves impairment of SERCA-derived relaxation and enhancement of tyrosine nitration in diabetic rat aorta.
Topics: Acetylcholine; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta, Thoracic; Blood Glucose; Blood Pressure; Diabetes Mellitus, Experimental; Enalapril; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Peroxynitrous Acid; Rats; Rats, Wistar; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Thapsigargin; Tyrosine | 2007 |
Prevention of peroxynitrite-induced apoptosis of motor neurons and PC12 cells by tyrosine-containing peptides.
Topics: Animals; Apoptosis; Free Radical Scavengers; Free Radicals; Motor Neurons; PC12 Cells; Peptides; Peroxynitrous Acid; Rats; Tyrosine | 2007 |
Nitration of specific tyrosine residues of cytochrome C is associated with caspase-cascade inactivation.
Topics: 5-Methoxytryptamine; Animals; Apoptosis; Caspase 3; Caspase 9; Caspases; Cell Line, Tumor; Chromatography, High Pressure Liquid; Cytochromes c; Enzyme Activation; Free Radical Scavengers; Nitrosation; Peptide Mapping; Peroxynitrous Acid; Protein Processing, Post-Translational; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Time Factors; Trypsin; Tyrosine | 2007 |
Role of peroxynitrite in endothelial damage mediated by Cyclosporine A.
Topics: Acetylcysteine; Animals; Antioxidants; Aorta; Cattle; Cell Membrane; Cell Survival; Cells, Cultured; Cyclosporine; Endothelial Cells; Immunosuppressive Agents; Mice; Mice, Inbred C57BL; Nitric Oxide; Peroxynitrous Acid; Superoxide Dismutase; Tyrosine | 2007 |
Molecular basis for susceptibility of plasma platelet-activating factor acetylhydrolase to oxidative inactivation.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Animals; Chlorocebus aethiops; COS Cells; Humans; Lipoproteins; Mice; Oxidants; Oxidative Stress; Oxygen; Peroxynitrous Acid; Phospholipases A; Phospholipases A2; Phospholipids; Reactive Oxygen Species; Tyrosine | 2007 |
iNOS-derived NO and nox2-derived superoxide confer tolerance to excitotoxic brain injury through peroxynitrite.
Topics: Animals; Body Temperature; Brain; Brain Injuries; Carotid Arteries; Guanidines; Ischemic Preconditioning; Ligation; Lipopolysaccharides; Male; Membrane Glycoproteins; Metalloporphyrins; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; NADPH Oxidase 2; NADPH Oxidases; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Superoxides; Tyrosine | 2007 |
Influence of oxygen tension on interleukin 1-induced peroxynitrite formation and matrix turnover in articular cartilage.
Topics: Animals; Antioxidants; Cartilage, Articular; Chondrocytes; Collagen; Drug Combinations; Extracellular Matrix; Female; Interleukin-1alpha; Metalloporphyrins; Oxygen; Peroxynitrous Acid; Proteoglycans; Swine; Tyrosine | 2007 |
Nitrotyrosine and protein carbonyls are equally distributed in HT22 cells after nitrosative stress.
Topics: Carbon; Cell Line, Tumor; Cytosol; Humans; Immunohistochemistry; Microscopy, Fluorescence; Nitric Oxide Donors; Nitrogen; Oxygen; Peroxynitrous Acid; Phenylhydrazines; Reactive Nitrogen Species; Reactive Oxygen Species; Tyrosine | 2007 |
Adiponectin cardioprotection after myocardial ischemia/reperfusion involves the reduction of oxidative/nitrative stress.
Topics: Adiponectin; Animals; Apoptosis; Cardiotonic Agents; Cells, Cultured; Male; Membrane Glycoproteins; Mice; Mice, Knockout; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Myocytes, Cardiac; NADPH Oxidase 2; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidative Stress; Peroxynitrous Acid; Reactive Nitrogen Species; Superoxides; Tumor Necrosis Factor-alpha; Tyrosine; Up-Regulation | 2007 |
Role of peroxynitrite on cytoskeleton alterations and apoptosis in renal ischemia-reperfusion.
Topics: Animals; Apoptosis; Blood Pressure; Blood Urea Nitrogen; Blotting, Western; Caspase 3; Cytoskeleton; In Situ Nick-End Labeling; Kidney Diseases; Kidney Function Tests; Male; Microscopy, Confocal; Peroxynitrous Acid; Rats; Rats, Wistar; Reperfusion Injury; Tyrosine | 2007 |
Temporal relationship of peroxynitrite-induced oxidative damage, calpain-mediated cytoskeletal degradation and neurodegeneration after traumatic brain injury.
Topics: Aldehydes; Animals; Brain; Brain Injuries; Calcium; Calpain; Cerebral Cortex; Cytoskeleton; Lipid Peroxidation; Male; Mice; Mice, Inbred Strains; Nerve Degeneration; Nerve Tissue Proteins; Nitrates; Oxidative Stress; Peroxynitrous Acid; Spectrin; Time Factors; Tissue Distribution; Tyrosine | 2007 |
Peroxynitrite oxidizes erythrocyte membrane band 3 protein and diminishes its anion transport capacity.
Topics: Acetylcysteine; Anion Exchange Protein 1, Erythrocyte; Anions; Catechin; Erythrocytes; Hemoglobins; Humans; Ion Transport; Nitrates; Oxidants; Oxidation-Reduction; Peroxynitrous Acid; Tyrosine | 2007 |
Peroxynitrite mild nitration of albumin and LDL-albumin complex naturally present in plasma and tyrosine nitration rate-albumin impairs LDL nitration.
Topics: Antioxidants; Atherosclerosis; Humans; Lipoproteins, LDL; Molsidomine; Nitric Oxide Donors; Nitrogen Dioxide; Oxidation-Reduction; Peroxynitrous Acid; Serum Albumin; Tyrosine | 2007 |
Metallothionein protects against doxorubicin-induced cardiomyopathy through inhibition of superoxide generation and related nitrosative impairment.
Topics: Animals; Antibiotics, Antineoplastic; Doxorubicin; Heart; Immunohistochemistry; Male; Metallothionein; Mice; Mice, Knockout; Myocardium; Peroxynitrous Acid; Superoxides; Troponin T; Tyrosine; Zinc | 2007 |
Neuronal NOS-mediated nitration and inactivation of manganese superoxide dismutase in brain after experimental and human brain injury.
Topics: Adolescent; Adult; Aged; Animals; Brain; Brain Injuries; Chemotaxis, Leukocyte; Encephalitis; Enzyme Activation; Enzyme Inhibitors; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Nerve Degeneration; Nitrates; Nitric Oxide Synthase Type I; Oxidative Stress; Peroxynitrous Acid; Superoxide Dismutase; Tyrosine | 2007 |
Reactive oxygen species plasmatic levels in ischemic stroke.
Topics: Aged; Atherosclerosis; Brain Ischemia; Case-Control Studies; Female; Humans; Male; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Peroxynitrous Acid; Reactive Oxygen Species; Thrombosis; Tyrosine | 2007 |
Probing structural differences in prion protein isoforms by tyrosine nitration.
Topics: Amino Acid Sequence; Animals; Circular Dichroism; Cricetinae; Hot Temperature; Mesocricetus; Peroxynitrous Acid; Prions; Protein Denaturation; Protein Isoforms; PrPC Proteins; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tandem Mass Spectrometry; Tetranitromethane; Tyrosine | 2007 |
Protein tyrosine nitration and poly(ADP-ribose) polymerase activation in N-methyl-N-nitro-N-nitrosoguanidine-treated thymocytes: implication for cytotoxicity.
Topics: Alkylating Agents; Animals; Apoptosis; Blotting, Western; Caspases; Cell Death; Cell Survival; Comet Assay; DNA Damage; DNA Fragmentation; Fluorescent Antibody Technique; Male; Methylnitronitrosoguanidine; Mice; Mice, Inbred C57BL; Mitochondria; Nitrates; Nitric Oxide; Peroxynitrous Acid; Poly(ADP-ribose) Polymerases; Superoxides; T-Lymphocytes; Tyrosine | 2007 |
Contrasting potential of nitric oxide and peroxynitrite to mediate oligodendrocyte injury in multiple sclerosis.
Topics: Astrocytes; Cell Death; Cells, Cultured; Demyelinating Diseases; Humans; Macrophages; Multiple Sclerosis; Myelin Sheath; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type II; Oligodendroglia; Peroxynitrous Acid; Tyrosine | 2007 |
Efficiency of lornoxicam in lung and trachea injury caused by peroxynitrite.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bronchoalveolar Lavage Fluid; Female; Lung; Male; Malondialdehyde; Peroxidase; Peroxynitrous Acid; Piroxicam; Rats; Respiratory Distress Syndrome; Trachea; Tracheal Diseases; Tyrosine | 2008 |
Peroxynitrite-mediated oxidative damage to brain mitochondria: Protective effects of peroxynitrite scavengers.
Topics: Aldehydes; Animals; Cell Respiration; Cerebral Cortex; Cyclic N-Oxides; Dose-Response Relationship, Drug; Electron Transport Complex I; Free Radical Scavengers; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Mitochondria; Molsidomine; Nitric Oxide Donors; Oxidative Stress; Oxygen Consumption; Penicillamine; Peroxynitrous Acid; Protein Carbonylation; Spin Labels; Tyrosine | 2007 |
A peroxynitrite-dependent pathway is responsible for blood-brain barrier permeability changes during a central nervous system inflammatory response: TNF-alpha is neither necessary nor sufficient.
Topics: Animals; Blood-Brain Barrier; CD4-Positive T-Lymphocytes; Cell Membrane Permeability; Cell Movement; Cerebellum; Encephalomyelitis, Autoimmune, Experimental; Female; Lymphopenia; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Peroxynitrous Acid; Rabies virus; Signal Transduction; T-Lymphocyte Subsets; Tumor Necrosis Factor-alpha; Tyrosine; Viral Load | 2007 |
The relationship between taurine and 3-nitrotyrosine level of hepatocytes in experimental endotoxemia.
Topics: Animals; Endotoxemia; Guinea Pigs; Hepatocytes; Lipopolysaccharides; Male; Peroxynitrous Acid; Taurine; Tyrosine | 2007 |
Insulin-induced impairment via peroxynitrite production of endothelium-dependent relaxation and sarco/endoplasmic reticulum Ca(2+)-ATPase function in aortas from diabetic rats.
Topics: Acetylcholine; Animals; Aorta; Diabetes Mellitus, Experimental; Endothelium, Vascular; Immunohistochemistry; Insulin; Male; Muscle, Smooth, Vascular; Nitrites; Nitroblue Tetrazolium; Oxidative Stress; Peroxynitrous Acid; Rats; Rats, Wistar; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Tyrosine | 2007 |
Regulation of cGMP-dependent protein kinase-mediated vasodilation by hypoxia-induced reactive species in ovine fetal pulmonary veins.
Topics: Animals; Cyclic GMP-Dependent Protein Kinase Type I; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Fetus; Hypoxia; Isoenzymes; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitrates; Nitrites; Peroxynitrous Acid; Pulmonary Veins; Reactive Nitrogen Species; Reactive Oxygen Species; Sheep; Time Factors; Tyrosine; Vasodilation | 2007 |
Metabolic memory phenomenon and accumulation of peroxynitrite in retinal capillaries.
Topics: Animals; Antioxidants; Blood Glucose; Capillaries; Diabetes Mellitus, Experimental; Glycated Hemoglobin; Immunologic Techniques; Insulin; Male; Osmolar Concentration; Peroxynitrous Acid; Rats; Rats, Inbred Lew; Retina; Retinal Vessels; Staining and Labeling; Superoxide Dismutase; Tyrosine | 2007 |
A peroxynitrite decomposition catalyst counteracts sensory neuropathy in streptozotocin-diabetic mice.
Topics: Animals; Behavior, Animal; Body Weight; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Fluorescent Antibody Technique; Hot Temperature; Hyperalgesia; Immunohistochemistry; Male; Metalloporphyrins; Mice; Mice, Inbred C57BL; Nerve Fibers; Neurons; Pain Threshold; Peroxynitrous Acid; Poly Adenosine Diphosphate Ribose; Reaction Time; Sciatic Nerve; Spinal Nerve Roots; Streptozocin; Tyrosine | 2007 |
Hypercholesterolemia increases myocardial oxidative and nitrosative stress thereby leading to cardiac dysfunction in apoB-100 transgenic mice.
Topics: Animals; Apolipoprotein B-100; Cholesterol; Cholesterol, Dietary; Female; Heart Diseases; Humans; Hypercholesterolemia; Immunohistochemistry; Metalloporphyrins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Models, Animal; Myocardium; NADPH Oxidases; Nitric Oxide Synthase; Oxidation-Reduction; Oxidative Stress; Peroxynitrous Acid; Regional Blood Flow; Superoxides; Triglycerides; Tyrosine | 2007 |
Beneficial effects of FeTSPP, a peroxynitrite decomposition catalyst, in a mouse model of spinal cord injury.
Topics: Animals; Catalysis; Disease Models, Animal; DNA; I-kappa B Proteins; Interleukin-1beta; Interleukin-2; Lipid Peroxidation; Male; Metalloporphyrins; Mice; Mitochondria; Neutrophil Infiltration; NF-kappa B; Peroxidase; Peroxynitrous Acid; Phosphorylation; Poly(ADP-ribose) Polymerases; Protein Transport; Proto-Oncogene Proteins c-bcl-2; RNA; Spinal Cord Injuries; T-Lymphocytes; Tumor Necrosis Factor-alpha; Tyrosine | 2007 |
Tyrosine phosphorylation/dephosphorylation regulates peroxynitrite-mediated peptide nitration.
Topics: Binding Sites; Chromatography, High Pressure Liquid; Hydrogen-Ion Concentration; Nitrates; Oligopeptides; Peptide Fragments; Peroxynitrous Acid; Phosphorylation; Tandem Mass Spectrometry; Tyrosine | 2007 |
Ebselen reduces nitration and restores voltage-gated potassium channel function in small coronary arteries of diabetic rats.
Topics: Adenylyl Cyclases; Animals; Antioxidants; Azoles; Colforsin; Coronary Vessels; Cyclic AMP; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Enzyme Activators; Isoindoles; Kv1.2 Potassium Channel; Kv1.5 Potassium Channel; Male; Membrane Potentials; Muscle, Smooth, Vascular; Organoselenium Compounds; Oxidative Stress; Peroxynitrous Acid; Potassium Channel Blockers; Protein Subunits; Rats; Rats, Sprague-Dawley; Research Design; Triterpenes; Tyrosine; Vasodilation | 2007 |
Proteasome-dependent degradation of guanosine 5'-triphosphate cyclohydrolase I causes tetrahydrobiopterin deficiency in diabetes mellitus.
Topics: Animals; Antioxidants; Aorta; Biopterins; Cells, Cultured; Cyclic N-Oxides; Cysteine Proteinase Inhibitors; Diabetes Mellitus, Experimental; Endothelial Cells; Glucose; GTP Cyclohydrolase; Guanosine Triphosphate; Leupeptins; Mice; Mice, Inbred C57BL; Nitrogen; Organ Culture Techniques; Peroxynitrous Acid; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Reactive Oxygen Species; Spin Labels; Tyrosine; Ubiquitin; Umbilical Veins | 2007 |
Nitration of a critical tyrosine residue in the allosteric inhibitor site of muscle glycogen phosphorylase impairs its catalytic activity.
Topics: Allosteric Regulation; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Glycogen Phosphorylase, Muscle Form; Mice; Models, Molecular; Molsidomine; Muscle Fibers, Skeletal; Muscle, Skeletal; Nitric Oxide Donors; Peroxynitrous Acid; Protein Structure, Tertiary; Tyrosine | 2007 |
Enhanced mitochondrial superoxide in hyperglycemic endothelial cells: direct measurements and formation of hydrogen peroxide and peroxynitrite.
Topics: Aconitate Hydratase; Animals; Catalase; Cattle; Cells, Cultured; Citric Acid Cycle; Endothelial Cells; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Glucose; Hydrogen Peroxide; Hyperglycemia; Immunohistochemistry; Membrane Potential, Mitochondrial; Microscopy, Fluorescence; Mitochondria; Nitric Oxide; Oxidation-Reduction; Oxidative Stress; Peroxynitrous Acid; Phenanthridines; Superoxides; Time Factors; Triazoles; Tyrosine | 2007 |
Peroxynitrite inactivation of human cytochrome P450s 2B6 and 2E1: heme modification and site-specific nitrotyrosine formation.
Topics: Amino Acid Sequence; Aryl Hydrocarbon Hydroxylases; Carbon Monoxide; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Enzyme Inhibitors; Heme; Humans; Models, Molecular; Molecular Sequence Data; Oxidoreductases, N-Demethylating; Peroxynitrous Acid; tert-Butylhydroperoxide; Tyrosine | 2007 |
Tyrosine nitration of IkappaBalpha: a novel mechanism for NF-kappaB activation.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Radiation; Female; Genes, Reporter; Humans; I-kappa B Proteins; Kinetics; Luciferases; Models, Molecular; Mutation; NF-kappa B; NF-KappaB Inhibitor alpha; Nitric Oxide Synthase Type I; Nitrogen; Nuclear Magnetic Resonance, Biomolecular; Oxidants; Peroxynitrous Acid; Protein Processing, Post-Translational; Quantum Theory; Radiation, Ionizing; RNA, Small Interfering; Transfection; Tyrosine | 2007 |
Role of nitrosative stress in early neuropathy and vascular dysfunction in streptozotocin-diabetic rats.
Topics: Animals; Aorta; Arterioles; Blood Glucose; Body Weight; Coronary Vessels; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Diabetic Neuropathies; Ganglia, Spinal; Hyperalgesia; Hypoglycemic Agents; Male; Mesenteric Arteries; Metalloporphyrins; Neural Conduction; Peroxynitrous Acid; Poly Adenosine Diphosphate Ribose; Rats; Rats, Wistar; Regional Blood Flow; Sciatic Nerve; Superoxides; Tyrosine; Vasodilator Agents | 2007 |
The role of caveolin-1 in PCB77-induced eNOS phosphorylation in human-derived endothelial cells.
Topics: Animals; Atherosclerosis; Caveolae; Caveolin 1; Cell Line; Cells, Cultured; Endothelial Cells; Environmental Pollutants; Enzyme Activation; Humans; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type III; Peroxynitrous Acid; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Polychlorinated Biphenyls; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; RNA Interference; RNA, Small Interfering; Signal Transduction; src-Family Kinases; Swine; Time Factors; Tyrosine | 2007 |
Incorporation of the hydrophobic probe N-t-BOC-L-tyrosine tert-butyl ester to red blood cell membranes to study peroxynitrite-dependent reactions.
Topics: Carbon Dioxide; Dimerization; Erythrocyte Membrane; Free Radicals; Humans; Hydrophobic and Hydrophilic Interactions; Nitrogen; Oxidation-Reduction; Oxyhemoglobins; Peroxynitrous Acid; Tyrosine | 2007 |
Mechanisms of chloroform-induced hepatotoxicity: oxidative stress and mitochondrial permeability transition in freshly isolated mouse hepatocytes.
Topics: Acetylcysteine; Alanine Transaminase; Animals; Antioxidants; Cells, Cultured; Chloroform; Cyclosporine; Female; Glutathione; Hepatocytes; Membrane Potential, Mitochondrial; Mice; Mice, Inbred Strains; Mitochondria, Liver; Nitric Oxide Synthase; Oxidative Stress; Peroxynitrous Acid; Reactive Oxygen Species; Tyrosine | 2007 |
Activity and subcellular trafficking of the sodium-coupled choline transporter CHT is regulated acutely by peroxynitrite.
Topics: Animals; Biotinylation; Cell Culture Techniques; Cell Line; Cell Line, Tumor; Cell Membrane; Choline; Cholinergic Agents; Culture Media; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation; Hemicholinium 3; Humans; Inhibitory Concentration 50; Kidney; Kinetics; L-Lactate Dehydrogenase; Luminescence; Membrane Potentials; Membrane Transport Proteins; Molsidomine; Neuroblastoma; Nitrogen; Oxidative Stress; Peroxynitrous Acid; Protein Transport; Rats; Sodium; Subcellular Fractions; Time Factors; Transfection; Tyrosine | 2008 |
When it comes to opiates, just say NO.
Topics: Analgesics, Opioid; Animals; Drug Tolerance; Mice; Morphine; Nitric Oxide; Peroxynitrous Acid; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Tyrosine | 2007 |
Therapeutic manipulation of peroxynitrite attenuates the development of opiate-induced antinociceptive tolerance in mice.
Topics: Analgesics, Opioid; Animals; Cytokines; DNA Damage; Drug Tolerance; Enzyme Inhibitors; Free Radical Scavengers; Humans; Male; Metalloporphyrins; Mice; NG-Nitroarginine Methyl Ester; Pain; Pain Threshold; Peroxynitrous Acid; Poly(ADP-ribose) Polymerases; Porphyrins; Rats; Spinal Cord; Superoxide Dismutase; Tyrosine | 2007 |
A profound decrease in maternal arginine uptake provokes endothelial nitration in the pregnant rat.
Topics: Animals; Aorta, Thoracic; Arginine; Blotting, Northern; Blotting, Western; Cationic Amino Acid Transporter 1; Endothelium, Vascular; Enzyme Inhibitors; Female; Gene Expression Regulation; Glyceraldehyde-3-Phosphate Dehydrogenases; Immunohistochemistry; Immunoprecipitation; Leukocytes; Nitrates; Peroxynitrous Acid; Placenta; Pregnancy; Pregnancy, Animal; Protein Kinase C; Rats; RNA, Messenger; Tyrosine; Vitamin E | 2008 |
S-nitrosylation of peroxiredoxin II E promotes peroxynitrite-mediated tyrosine nitration.
Topics: Arabidopsis; Arabidopsis Proteins; Chromatography, Liquid; Lipid Peroxidation; Models, Biological; Nitrates; Peroxiredoxins; Peroxynitrous Acid; Plants, Genetically Modified; Tandem Mass Spectrometry; Tyrosine | 2007 |
Vascular leakage induced by exposure to arsenic via increased production of NO, hydroxyl radical and peroxynitrite.
Topics: Animals; Arsenites; Blood Vessels; Capillary Permeability; Carbon; Dose-Response Relationship, Drug; Drug Therapy, Combination; Enzyme Inhibitors; Evans Blue; Free Radical Scavengers; Guanidines; Hydroxyl Radical; Injections, Intradermal; Injections, Intravenous; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Skin; Sodium Compounds; Thiourea; Tyrosine | 2008 |
Peroxynitrite mediates retinal neurodegeneration by inhibiting nerve growth factor survival signaling in experimental and human diabetes.
Topics: Animals; Cadaver; Cell Death; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Humans; Lipid Peroxidation; Middle Aged; Nerve Degeneration; Nerve Growth Factor; Optic Nerve; Peroxynitrous Acid; Rats; Reference Values; Retinal Ganglion Cells; RNA, Messenger; Streptozocin; Tyrosine | 2008 |
Role of redox signaling and poly (adenosine diphosphate-ribose) polymerase activation in vascular smooth muscle cell growth inhibition by nitric oxide and peroxynitrite.
Topics: Animals; Antioxidants; Apoptosis; Cell Proliferation; Cell Survival; Cells, Cultured; Cyclic GMP; DNA Replication; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitric Oxide; Nitric Oxide Donors; Oxidation-Reduction; Peroxynitrous Acid; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Rats; Signal Transduction; Superoxides; Time Factors; Tyrosine; Vasodilation | 2008 |
Glutathionylation of the iron superoxide dismutase from the psychrophilic eubacterium Pseudoalteromonas haloplanktis.
Topics: Chromatography, High Pressure Liquid; Cysteine; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Escherichia coli; Eubacterium; Glutathione; Mass Spectrometry; Mutant Proteins; Peroxynitrous Acid; Pseudoalteromonas; Recombinant Proteins; Superoxide Dismutase; Tyrosine | 2008 |
Peroxynitrite inactivates human-tissue inhibitor of metalloproteinase-4.
Topics: Animals; Cattle; Cell Line, Tumor; Cell Movement; Cells, Cultured; Endothelium, Vascular; Humans; Peroxynitrous Acid; Tissue Inhibitor of Metalloproteinase-4; Tissue Inhibitor of Metalloproteinases; Tyrosine | 2008 |
Differential patterns of peroxynitrite mediated apoptosis in proximal tubular epithelial cells following ATP depletion recovery.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Caspase 3; Caspase Inhibitors; Enzyme Activation; L-Lactate Dehydrogenase; LLC-PK1 Cells; Metalloporphyrins; Mitochondria; Models, Animal; Peroxynitrous Acid; Reperfusion Injury; Swine; Tyrosine | 2008 |
Antioxidant potential of dimethyl lithospermate isolated from Salvia miltiorrhiza (red sage) against peroxynitrite.
Topics: Animals; Antioxidants; Benzofurans; Cell Line; Endothelial Cells; Free Radical Scavengers; Peroxynitrous Acid; Rats; Salvia miltiorrhiza; Tyrosine | 2008 |
First evidence for an LDL- and HDL-associated nitratase activity that denitrates albumin-bound nitrotyrosine--physiological consequences.
Topics: Calcium; Humans; Lipoproteins, HDL; Lipoproteins, LDL; Oxidoreductases; Peroxynitrous Acid; Serum Albumin; Tyrosine | 2008 |
Asymmetric dimethylarginine inhibits HSP90 activity in pulmonary arterial endothelial cells: role of mitochondrial dysfunction.
Topics: Adenosine Triphosphate; Animals; Arginine; Cells, Cultured; HSP90 Heat-Shock Proteins; Humans; Ion Channels; Mitochondria; Mitochondrial Proteins; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Peroxynitrous Acid; Protein Binding; Protein Transport; Pulmonary Artery; Recombinant Proteins; Sheep; Signal Transduction; Superoxides; Tyrosine; Uncoupling Protein 2 | 2008 |
The protective effect of hypotaurine and cysteine sulphinic acid on peroxynitrite-mediated oxidative reactions.
Topics: Antioxidants; Cysteine; Dimerization; Dose-Response Relationship, Drug; Glutathione; Humans; Models, Chemical; Nitrites; Oxidation-Reduction; Oxygen; Oxygen Consumption; Peroxynitrous Acid; Rhodamines; Taurine; Tyrosine | 2008 |
Loss of 3-chlorotyrosine by inflammatory oxidants: implications for the use of 3-chlorotyrosine as a bio-marker in vivo.
Topics: Animals; Biomarkers; HL-60 Cells; Humans; Hypochlorous Acid; Inflammation; Macrophage Activation; Macrophages; Mice; Neutrophils; Nitrites; Oxidants; Peroxidase; Peroxynitrous Acid; Reactive Oxygen Species; Tyrosine | 2008 |
Differential contribution of neutrophilic granulocytes and macrophages to nitrosative stress in a host-parasite animal model.
Topics: Animals; B-Lymphocytes; Carps; Cell Death; Gene Expression Regulation, Enzymologic; Host-Parasite Interactions; Macrophages; Melarsoprol; Models, Animal; Neutrophils; Nitric Oxide; Nitric Oxide Synthase Type II; Nitrites; Parasitemia; Parasites; Peroxidase; Peroxynitrous Acid; Reactive Nitrogen Species; Spleen; Stress, Physiological; Trypanosoma; Trypanosomiasis; Tyrosine | 2008 |
Immunolocalization of Kim-1, RPA-1, and RPA-2 in kidney of gentamicin-, mercury-, or chromium-treated rats: relationship to renal distributions of iNOS and nitrotyrosine.
Topics: Animals; Antigens; Apoptosis; Biomarkers; Cell Adhesion Molecules; Disease Models, Animal; Dose-Response Relationship, Drug; Fluorescent Antibody Technique, Indirect; Gentamicins; Immunoenzyme Techniques; Immunohistochemistry; Kidney; Kidney Tubules, Proximal; Male; Mercuric Chloride; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Potassium Dichromate; Rats; Rats, Sprague-Dawley; Tyrosine; Up-Regulation; Xenobiotics | 2008 |
Interaction of dicaffeoylquinic derivatives with peroxynitrite and other reactive nitrogen species.
Topics: Animals; Bicarbonates; Catechin; Cattle; Fibroblasts; Humans; Inhibitory Concentration 50; Lipopolysaccharides; Macrophages; Mice; Neutrophils; Nitrates; Nitric Oxide Synthase Type II; Nitrites; Oxidation-Reduction; Peroxynitrous Acid; Quinic Acid; Reactive Nitrogen Species; Serum Albumin, Bovine; Stimulation, Chemical; Tetradecanoylphorbol Acetate; Tyrosine | 2008 |
Effects of angiotensin converting enzyme inhibitor and angiotensin II receptor antagonist combination on nitric oxide bioavailability and atherosclerotic change in Watanabe heritable hyperlipidemic rabbits.
Topics: Acetylcholine; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta, Abdominal; Atherosclerosis; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Enalapril; Heart Rate; Hyperlipidemias; Losartan; Male; Nitric Oxide; Peroxynitrous Acid; Rabbits; Tyrosine; Vasodilator Agents | 2008 |
Arginase 2 is expressed by human lung cancer, but it neither induces immune suppression, nor affects disease progression.
Topics: Adult; Aged; Aged, 80 and over; Arginase; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Cell Proliferation; Disease Progression; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Italy; Lung Neoplasms; Male; Microscopy, Confocal; Middle Aged; Neoplasm Staging; Nitric Oxide Synthase; Nitrites; Peroxynitrous Acid; Reverse Transcriptase Polymerase Chain Reaction; T-Lymphocytes; Tyrosine | 2008 |
Tyrosine nitration, dimerization, and hydroxylation by peroxynitrite in membranes as studied by the hydrophobic probe N-t-BOC-l-tyrosine tert-butyl ester.
Topics: Dimerization; Electron Spin Resonance Spectroscopy; Humans; Hydrophobic and Hydrophilic Interactions; Hydroxylation; Liposomes; Models, Biological; Molecular Probe Techniques; Molecular Probes; Nitrates; Peroxynitrous Acid; Proteins; Spin Trapping; Tyrosine | 2008 |
Degradation of extracellular matrix by peroxynitrite/peroxynitrous acid.
Topics: Animals; Bicarbonates; Cells, Cultured; Extracellular Matrix; Hydrogen-Ion Concentration; Molecular Structure; Molsidomine; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Peroxynitrous Acid; Rats; Swine; Tyrosine | 2008 |
Glycyrrhizin attenuates the development of carrageenan-induced lung injury in mice.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Enzyme Activation; Glycyrrhizic Acid; Intercellular Adhesion Molecule-1; Interleukin-1beta; Lipid Peroxidation; Lung; Male; Mice; Neutrophils; NF-kappa B; P-Selectin; Peroxynitrous Acid; Pleurisy; Poly Adenosine Diphosphate Ribose; STAT3 Transcription Factor; Tumor Necrosis Factor-alpha; Tyrosine | 2008 |
The peroxynitrite donor 3-morpholinosydnonimine induces reversible changes in electrophysiological properties of neurons of the guinea-pig spinal cord.
Topics: Action Potentials; Animals; Axons; Cell Membrane; Dose-Response Relationship, Drug; Extracellular Fluid; Female; Guinea Pigs; Molsidomine; Nerve Degeneration; Neural Conduction; Neurons; Nitric Oxide; Nitric Oxide Donors; Nitro Compounds; Peroxynitrous Acid; Sodium Channels; Spinal Cord; Spinal Cord Injuries; Tyrosine | 2008 |
Protein tyrosine nitration of the flavin subunit is associated with oxidative modification of mitochondrial complex II in the post-ischemic myocardium.
Topics: Animals; Cattle; Electron Transport Complex II; Mitochondria, Heart; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide; Oxidation-Reduction; Peroxynitrous Acid; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; Superoxides; Tyrosine | 2008 |
Interaction between COX-2 and iNOS aggravates vascular lesion and antagonistic effect of ginsenoside.
Topics: Animals; Blotting, Western; Cyclooxygenase 2; Endothelium, Vascular; Gene Expression; Ginsenosides; Immunoprecipitation; Male; Medicine, Chinese Traditional; Microscopy, Confocal; Nitric Oxide Synthase Type II; Panax; Peroxynitrous Acid; Plant Roots; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tyrosine | 2008 |
The reactive nitrogen species peroxynitrite is a potent inhibitor of renal Na-K-ATPase activity.
Topics: Animals; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; In Vitro Techniques; Kidney; Ouabain; Peroxynitrous Acid; Protein Conformation; Sodium-Potassium-Exchanging ATPase; Tyrosine | 2008 |
LDL protein nitration: implication for LDL protein unfolding.
Topics: Animals; Aorta; Apolipoprotein B-100; Cattle; Cells, Cultured; Cysteine; Dose-Response Relationship, Drug; Endothelial Cells; Endothelium, Vascular; Humans; Lipid Peroxidation; Lipid Peroxides; Lipoproteins, LDL; Models, Chemical; Molsidomine; Oxidation-Reduction; Peroxynitrous Acid; Protein Conformation; Protein Denaturation; Protein Processing, Post-Translational; Protein Structure, Secondary; Proteins; Reproducibility of Results; Tyrosine | 2008 |
Amelioration of neurological and biochemical deficits by peroxynitrite decomposition catalysts in experimental diabetic neuropathy.
Topics: Animals; Blood Glucose; Catalysis; Diabetic Neuropathies; Glutathione; Male; Metalloporphyrins; Neural Conduction; Peroxynitrous Acid; Poly Adenosine Diphosphate Ribose; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Sciatic Nerve; Tyrosine | 2008 |
Significance of ERK nitration in portal hypertensive gastropathy and its therapeutic implications.
Topics: Alanine; Animals; Enzyme Inhibitors; Ethanol; Extracellular Signal-Regulated MAP Kinases; Gastric Mucosa; Liver Cirrhosis; MAP Kinase Kinase Kinases; Nitrates; Oxidative Stress; Peroxynitrous Acid; Quinolones; Rats; Rats, Sprague-Dawley; Signal Transduction; Stomach Diseases; Tyrosine | 2008 |
Peroxynitrite decreases arrhythmias induced by ischaemia reperfusion in anaesthetized dogs, without involving mitochondrial KATP channels.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Vessels; Decanoic Acids; Dogs; Female; Hydroxy Acids; Male; Myocardial Reperfusion Injury; Peroxynitrous Acid; Potassium Channels; Severity of Illness Index; Survival Rate; Tyrosine; Ventricular Fibrillation | 2008 |
Exogenous superoxide dismutase prevents peroxynitrite-induced apoptosis in non-heart-beating donor livers.
Topics: Alanine Transaminase; Animals; Apoptosis; Glutamate Dehydrogenase; Immunohistochemistry; Liver; Male; Peroxynitrous Acid; Portal Vein; Rats; Rats, Wistar; Superoxide Dismutase; Tissue Donors; Tyrosine | 2008 |
Lung-protective effects of the metalloporphyrinic peroxynitrite decomposition catalyst WW-85 in interleukin-2 induced toxicity.
Topics: Animals; Capillary Leak Syndrome; Capillary Permeability; Catalysis; Hemodynamics; Interleukin-2; Lung; Lymph; Malondialdehyde; Neoplasms; Nitric Oxide; Nitric Oxide Synthase Type II; Peroxidase; Peroxynitrous Acid; Pulmonary Gas Exchange; Recombinant Proteins; Sheep; Tyrosine | 2008 |
Nitration of solvent-exposed tyrosine 74 on cytochrome c triggers heme iron-methionine 80 bond disruption. Nuclear magnetic resonance and optical spectroscopy studies.
Topics: Amino Acid Substitution; Animals; Apoptosis; Cardiolipins; Cytochromes c; Heme; Horses; Hydrogen-Ion Concentration; Iron; Mitochondrial Proteins; Nuclear Magnetic Resonance, Biomolecular; Oxidation-Reduction; Peroxynitrous Acid; Point Mutation; Protein Processing, Post-Translational; Tyrosine | 2009 |
[Study on ratiometric determination of peroxynitrite and its scavenger based on synchronous fluorescence spectroscopy].
Topics: Buffers; Carbon Dioxide; Catalysis; Models, Chemical; Molecular Structure; Peroxynitrous Acid; Radiometry; Spectrometry, Fluorescence; Tyrosine | 2008 |
Protein nitration, PARP activation and NAD+ depletion may play a critical role in the pathogenesis of cyclophosphamide-induced hemorrhagic cystitis in the rat.
Topics: Animals; Antineoplastic Agents, Alkylating; Antioxidants; Cyclophosphamide; Cystitis; Hemorrhage; Immunoenzyme Techniques; Male; Malondialdehyde; NAD; Nitric Oxide; Oxidative Stress; Peroxynitrous Acid; Poly(ADP-ribose) Polymerases; Rats; Rats, Wistar; Superoxide Dismutase; Tyrosine; Urinary Bladder | 2009 |
Synthesis and biological activities of neoechinulin A derivatives: new aspects of structure-activity relationships for neoechinulin A.
Topics: Animals; Antioxidants; Brain Chemistry; Cell Survival; Indicators and Reagents; Indole Alkaloids; Lipid Peroxidation; Magnetic Resonance Spectroscopy; Molsidomine; Nitrates; PC12 Cells; Peroxynitrous Acid; Piperazines; Protective Agents; Rats; Structure-Activity Relationship; Tyrosine | 2008 |
The effect of neighboring methionine residue on tyrosine nitration and oxidation in peptides treated with MPO, H2O2, and NO2(-) or peroxynitrite and bicarbonate: role of intramolecular electron transfer mechanism?
Topics: Acetylation; Bicarbonates; Electron Spin Resonance Spectroscopy; Electron Transport; Hydrogen Peroxide; Kinetics; Methionine; Nitrates; Peptides; Peroxidase; Peroxynitrous Acid; Reactive Nitrogen Species; Tyrosine | 2009 |
Reactive oxygen-induced reactive oxygen formation during human sperm capacitation.
Topics: Acrosome Reaction; Animals; Arginine; Blood Proteins; Bucladesine; Cattle; Cell-Free System; Cells, Cultured; Female; Fetal Blood; Humans; Hydrazines; Infant, Newborn; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Peroxynitrous Acid; Phosphorylation; Pregnancy; Serum Albumin, Bovine; Sperm Capacitation; Spermatozoa; Superoxide Dismutase; Superoxides; Tyrosine | 2009 |
Modification of surfactant protein D by reactive oxygen-nitrogen intermediates is accompanied by loss of aggregating activity, in vitro and in vivo.
Topics: Amino Acid Sequence; Animals; Bronchoalveolar Lavage Fluid; Humans; Mice; Molsidomine; Nitrogen Dioxide; Peroxynitrous Acid; Protein Structure, Quaternary; Protein Structure, Tertiary; Pulmonary Surfactant-Associated Protein D; Rats; Recombinant Proteins; Tandem Mass Spectrometry; Tyrosine | 2009 |
Oxidation and nitration of ribonuclease and lysozyme by peroxynitrite and myeloperoxidase.
Topics: Animals; Cattle; Chickens; Chromatography, High Pressure Liquid; Egg White; Free Radicals; Hydrogen Peroxide; Inflammation; Muramidase; Peroxidase; Peroxynitrous Acid; Pronase; Proteins; Ribonucleases; Spectrometry, Mass, Electrospray Ionization; Spleen; Tyrosine | 2009 |
Inactivation of rabbit muscle glycogen phosphorylase b by peroxynitrite revisited: does the nitration of Tyr613 in the allosteric inhibition site control enzymatic function?
Topics: Allosteric Site; Amino Acid Sequence; Animals; Cysteine; Glycogen Phosphorylase, Muscle Form; Kinetics; Models, Molecular; Molecular Sequence Data; Muscle, Skeletal; Nitrates; Peptide Fragments; Peroxynitrous Acid; Protein Conformation; Rabbits; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Trypsin; Tyrosine | 2009 |
Nitric oxide platelet production in spontaneous miscarriage in the first trimester.
Topics: Abortion, Spontaneous; Adult; Blood Platelets; Case-Control Studies; Female; Humans; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Peroxynitrous Acid; Pregnancy; Pregnancy Trimester, First; Retrospective Studies; Tyrosine | 2010 |
Amyloid-dependent triosephosphate isomerase nitrotyrosination induces glycation and tau fibrillation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Blotting, Western; Case-Control Studies; Cell Line; Cell Line, Tumor; Frontal Lobe; Humans; Immunohistochemistry; Mice; Mice, Transgenic; Microscopy, Atomic Force; Microscopy, Confocal; Microscopy, Electron; Models, Molecular; Neuroblastoma; Neurofibrillary Tangles; Oxidative Stress; Peroxynitrous Acid; Phosphorylation; tau Proteins; Triose-Phosphate Isomerase; Tyrosine | 2009 |
Role of superoxide, nitric oxide, and peroxynitrite in doxorubicin-induced cell death in vivo and in vitro.
Topics: Animals; Antibiotics, Antineoplastic; Antioxidants; Apoptosis; Cell Line; Dose-Response Relationship, Drug; Doxorubicin; Enzyme Inhibitors; Free Radical Scavengers; Heart Diseases; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria, Heart; Myocardial Contraction; Myocytes, Cardiac; Necrosis; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Poly(ADP-ribose) Polymerases; Superoxides; Tyrosine; Ventricular Function, Left; Ventricular Pressure | 2009 |
Chronic production of peroxynitrite in the vascular wall impairs vasorelaxation function in SHR/NDmcr-cp rats, an animal model of metabolic syndrome.
Topics: Acetylcholine; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzimidazoles; Benzoates; Blood Vessels; Blotting, Western; Enzyme Activation; Immunoenzyme Techniques; Luminescence; Male; Metabolic Syndrome; NADPH Oxidases; Nitric Oxide Synthase Type III; Nitroprusside; Peroxynitrous Acid; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Telmisartan; Tyrosine; Vasoconstrictor Agents; Vasodilation | 2009 |
Mechanisms of peroxynitrite-mediated nitration of tyrosine.
Topics: Carbon Dioxide; Carbonates; Hydroxyl Radical; Nitrates; Nitrogen Dioxide; Peroxynitrous Acid; Tyrosine | 2009 |
Understanding peroxynitrite biochemistry and its potential for treating human diseases.
Topics: Bacteria; Biochemistry; Cell Death; Disease; Humans; Macrophages, Alveolar; Nitrates; Nitrophenols; Peroxynitrous Acid; Superoxide Dismutase; Superoxides; Tyrosine | 2009 |
Peroxynitrite induces gene expression in intervertebral disc cells.
Topics: Active Transport, Cell Nucleus; Adolescent; Adult; Cell Nucleus; Cells, Cultured; Female; Gene Expression; Humans; Immunohistochemistry; Interleukin-10; Interleukin-1beta; Interleukin-6; Interleukin-8; Intervertebral Disc; Intervertebral Disc Displacement; Male; Middle Aged; Molsidomine; Nitric Oxide Donors; Peroxynitrous Acid; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factor RelA; Tumor Necrosis Factor-alpha; Tyrosine | 2009 |
C-reactive protein impairs coronary arteriolar dilation to prostacyclin synthase activation: role of peroxynitrite.
Topics: Animals; Arachidonic Acid; Arterioles; C-Reactive Protein; Cell Separation; Cytochrome P-450 Enzyme System; Enzyme Activation; Epoprostenol; Immunohistochemistry; Intramolecular Oxidoreductases; Nitric Oxide; Nitroprusside; Peroxynitrous Acid; Serotonin; Sus scrofa; Tyrosine; Vasodilation; Vasomotor System | 2009 |
Effects of a metalloporphyrinic peroxynitrite decomposition catalyst, ww-85, in a mouse model of spinal cord injury.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Cytokines; Disease Models, Animal; Immunoenzyme Techniques; In Situ Nick-End Labeling; Lipid Peroxidation; Male; Mice; Motor Activity; Neutrophil Infiltration; NF-kappa B; Peroxidase; Peroxynitrous Acid; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Spinal Cord Injuries; Thiobarbituric Acid Reactive Substances; Tyrosine | 2009 |
Blockade of peroxynitrite-induced neural stem cell death in the acutely injured spinal cord by drug-releasing polymer.
Topics: Acute Disease; Animals; Annexin A5; Blotting, Western; Caspases; Cell Death; Cell Line; Cytoprotection; Drug Delivery Systems; Enzyme Activation; Fluoresceins; Free Radical Scavengers; Glycolates; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Lactic Acid; Neurons; Nitric Oxide; Peroxynitrous Acid; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Signal Transduction; Spinal Cord Injuries; Stem Cells; Tyrosine | 2009 |
Temporal and spatial dynamics of peroxynitrite-induced oxidative damage after spinal cord contusion injury.
Topics: Aldehydes; Animals; Female; Immunohistochemistry; Lipid Peroxidation; Neurons; Oxidative Stress; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Cord Injuries; Thoracic Vertebrae; Time Factors; Tyrosine | 2009 |
Effects of peroxynitrite-induced protein tyrosine nitration on insulin-stimulated tyrosine phosphorylation in HepG2 cells.
Topics: Cell Extracts; Electrophoresis, Polyacrylamide Gel; Hep G2 Cells; Humans; Insulin; Nitrates; Peroxynitrous Acid; Phosphorylation; Proteins; Subcellular Fractions; Tyrosine | 2009 |
A novel marine compound xyloketal B protects against oxidized LDL-induced cell injury in vitro.
Topics: Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Endothelial Cells; Endothelium, Vascular; Fluoresceins; Fluorescent Dyes; Formazans; Humans; Indoles; Lipoproteins, LDL; Molecular Structure; NADPH Oxidases; Nitric Oxide; Oxidation-Reduction; Peroxynitrous Acid; Pyrans; Reactive Oxygen Species; Tetrazolium Salts; Time Factors; Tyrosine; Umbilical Veins; Xylariales | 2009 |
Tempol protection of spinal cord mitochondria from peroxynitrite-induced oxidative damage.
Topics: Animals; Antioxidants; Cell Respiration; Cyclic N-Oxides; Female; Mitochondria; Molsidomine; Nitric Oxide Donors; Nitroso Compounds; Oxidative Stress; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Spin Labels; Spinal Cord; Tyrosine | 2009 |
Linoleic acid-induced mitochondrial Ca(2+) efflux causes peroxynitrite generation and protein nitrotyrosylation.
Topics: Animals; Calcium; Diabetes Mellitus, Experimental; Fatty Acids, Unsaturated; Gene Expression Regulation; HSP90 Heat-Shock Proteins; Humans; Immunohistochemistry; Kidney; Linoleic Acid; Mice; Mitochondria; Models, Biological; Peroxynitrous Acid; Tyrosine | 2009 |
Tyrosine nitration of PA700 activates the 26S proteasome to induce endothelial dysfunction in mice with angiotensin II-induced hypertension.
Topics: Angiotensin II; Animals; Aorta; Biopterins; Blood Pressure; Cells, Cultured; Cysteine Proteinase Inhibitors; Endothelial Cells; Endothelium, Vascular; GTP Cyclohydrolase; Humans; Hypertension; In Vitro Techniques; Leupeptins; Mice; Mice, Inbred C57BL; Nitrates; Peroxynitrous Acid; Proteasome Endopeptidase Complex; Proteasome Inhibitors; RNA, Small Interfering; Transfection; Tyrosine; Vasodilation | 2009 |
Amyloid beta-induced nerve growth factor dysmetabolism in Alzheimer disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; CD40 Antigens; Disease Models, Animal; Female; Humans; Immunoprecipitation; Male; Matrix Metalloproteinase 9; Maze Learning; Mice; Mice, Transgenic; Minocycline; Nerve Growth Factor; Nerve Growth Factors; Nitric Oxide Synthase Type II; Peptide Fragments; Peroxynitrous Acid; Protein Precursors; Rats; Rats, Inbred F344; Reaction Time; Tyrosine; Up-Regulation | 2009 |
Peroxynitrite mediates glomerular lesion of diabetic rat via JAK/STAT signaling pathway.
Topics: Animals; Blotting, Western; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Fibronectins; Immunohistochemistry; Janus Kinase 2; Kidney Glomerulus; Male; Microscopy, Electron, Transmission; Peroxynitrous Acid; Phosphorylation; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; STAT1 Transcription Factor; STAT3 Transcription Factor; Transforming Growth Factor beta; Tyrosine; Uric Acid | 2009 |
Peroxynitrite and heme protein--mediated nitrative/oxidative modification of human plasma protein: the role of free radical scavenging vs. complex forming.
Topics: Antioxidants; Blood Proteins; Chromans; Deferoxamine; Free Radical Scavengers; Glutathione; Hemeproteins; Humans; Oxidants; Oxidation-Reduction; Peroxynitrous Acid; Tyrosine | 2009 |
Role of MCP-1 in tumor necrosis factor-alpha-induced endothelial dysfunction in type 2 diabetic mice.
Topics: Animals; Arterioles; Biomarkers; Chemokine CCL2; Coronary Vessels; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; I-kappa B Proteins; Inflammation Mediators; Macrophages; Male; Mice; Mice, Knockout; NF-kappa B; Nitric Oxide; Oxidative Stress; Peroxynitrous Acid; Phosphorylation; Receptors, Leptin; Serine; Signal Transduction; Superoxides; Tumor Necrosis Factor-alpha; Tyrosine; Vascular Cell Adhesion Molecule-1; Vasodilation; Vasodilator Agents | 2009 |
Quercetin metabolites and protection against peroxynitrite-induced oxidative hepatic injury in rats.
Topics: Animals; Galactosamine; Humans; Lipopolysaccharides; Liver; Liver Failure, Acute; Male; Oxidative Stress; Peroxynitrous Acid; Quercetin; Rats; Rats, Sprague-Dawley; Tyrosine | 2009 |
Inhibition of the soluble epoxide hydrolase by tyrosine nitration.
Topics: Animals; Cells, Cultured; Endothelial Cells; Enzyme Inhibitors; Epoxide Hydrolases; Humans; Mice; Mice, Inbred C57BL; Mice, Obese; Molsidomine; Mutagenesis, Site-Directed; Oxidative Stress; Peroxynitrous Acid; Tyrosine | 2009 |
Direct detection of the oxygen rebound intermediates, ferryl Mb and NO2, in the reaction of metmyoglobin with peroxynitrite.
Topics: Animals; Horses; Kinetics; Metmyoglobin; Models, Molecular; Myoglobin; Nitrogen Dioxide; Oxygen; Peroxynitrous Acid; Tyrosine | 2009 |
Lipoprotein lipase is nitrated in vivo after lipopolysaccharide challenge.
Topics: Animals; Cattle; Endotoxemia; Hypertriglyceridemia; Lipopolysaccharides; Lipoprotein Lipase; Male; Myocardium; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidative Stress; Peroxynitrous Acid; Rats; Rats, Wistar; Tandem Mass Spectrometry; Tyrosine | 2009 |
Cholesterol diet-induced hyperlipidemia impairs the cardioprotective effect of postconditioning: role of peroxynitrite.
Topics: Animals; Biomarkers; Cholesterol, Dietary; Disease Models, Animal; Hyperlipidemias; Male; Metalloporphyrins; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Peroxynitrous Acid; Rats; Signal Transduction; Stress, Physiological; Tyrosine | 2009 |
Peroxynitrite induces tyrosine residue modifications in synaptophysin C-terminal domain, affecting its interaction with src.
Topics: Animals; Brain; Male; Mass Spectrometry; Peroxynitrous Acid; Protein Binding; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; Signal Transduction; src Homology Domains; src-Family Kinases; Synaptophysin; Synaptosomes; Tyrosine | 2009 |
Superoxide signaling in pain is independent of nitric oxide signaling.
Topics: Animals; Antimycin A; Cyclic N-Oxides; Disease Models, Animal; Enzyme Inhibitors; Hyperalgesia; Male; Metalloporphyrins; Mice; Mice, Inbred C57BL; Neuralgia; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroso Compounds; Pain Measurement; Peroxynitrous Acid; Reactive Oxygen Species; Signal Transduction; Spin Labels; Superoxides; Tyrosine | 2009 |
Early intervention of tyrosine nitration prevents vaso-obliteration and neovascularization in ischemic retinopathy.
Topics: Acetylcysteine; Animals; Animals, Newborn; Apoptosis; Blotting, Western; Catechin; Cells, Cultured; Disease Models, Animal; Endothelial Cells; Glutathione; Hyperoxia; Hypoxia; Ischemia; Lipid Peroxidation; Metalloporphyrins; Mice; Mice, Inbred C57BL; Peroxynitrous Acid; Protective Agents; Retinal Neovascularization; Retinal Vessels; Tyrosine | 2010 |
Physicochemical studies on peroxynitrite-modified H3 histone.
Topics: Animals; Cattle; Chemical Phenomena; Chromatography, High Pressure Liquid; Circular Dichroism; Electrophoresis, Polyacrylamide Gel; Histones; Hydrolysis; Peroxynitrous Acid; Protein Denaturation; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Temperature; Trypsin; Tyrosine | 2010 |
The role of superoxide anion in the inhibitory effect of SIN-1 in thrombin-activated human platelet adhesion.
Topics: Blood Platelets; Blood Proteins; Cell Adhesion; Enzyme Inhibitors; Fibrinogen; Free Radical Scavengers; Guanylate Cyclase; Humans; Molsidomine; Nitrates; Peroxynitrous Acid; Solubility; Superoxides; Thrombin; Tyrosine | 2010 |
[The protective effect of nourishing yin and promoting blood flow recipe on the aortic endothelium injury of diabetic rats].
Topics: Animals; Aorta; Blotting, Western; Diabetes Mellitus, Experimental; Drugs, Chinese Herbal; Endothelium, Vascular; Female; Male; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Random Allocation; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tyrosine | 2009 |
Formation of methionine sulfoxide by peroxynitrite at position 1606 of von Willebrand factor inhibits its cleavage by ADAMTS-13: A new prothrombotic mechanism in diseases associated with oxidative stress.
Topics: ADAM Proteins; ADAMTS13 Protein; Adult; Binding Sites; Blood Platelets; Case-Control Studies; Diabetes Mellitus, Type 2; Female; Humans; Hydrolysis; Male; Methionine; Middle Aged; Oxidative Stress; Peptide Fragments; Peroxynitrous Acid; Platelet Aggregation; Protein Multimerization; Ristocetin; Tyrosine; von Willebrand Diseases; von Willebrand Factor | 2010 |
Hyaluronan reversed proteoglycan synthesis inhibited by mechanical stress: possible involvement of antioxidant effect.
Topics: Animals; Antioxidants; Blotting, Western; Cartilage; Cattle; Chondrocytes; DNA Primers; Hyaluronic Acid; Luminescence; Nitric Oxide; Organ Culture Techniques; Peroxynitrous Acid; Proteoglycans; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; Stress, Mechanical; Sulfur Radioisotopes; Superoxides; Tyrosine | 2010 |
Antithyroid drugs and their analogues protect against peroxynitrite-mediated protein tyrosine nitration--a mechanistic study.
Topics: Animals; Antithyroid Agents; Cattle; Cytochromes c; Methimazole; Peroxynitrous Acid; Selenium; Serum Albumin, Bovine; Thermodynamics; Thiouracil; Tyrosine | 2010 |
L-carnitine modulates blood platelet oxidative stress.
Topics: Adenosine Diphosphate; Adult; Blood Platelets; Carnitine; Glutathione; Humans; Male; Nitrosation; Oxidative Stress; Peroxynitrous Acid; Platelet Aggregation; Protein Carbonylation; Sulfhydryl Compounds; Superoxides; Thiobarbituric Acid Reactive Substances; Tyrosine; Young Adult | 2010 |
Cyclosporine A-induced nitration of tyrosine 34 MnSOD in endothelial cells: role of mitochondrial superoxide.
Topics: Aconitate Hydratase; Animals; Cattle; Cell Respiration; Cells, Cultured; Cyclosporine; Electron Spin Resonance Spectroscopy; Endothelial Cells; Immunosuppressive Agents; Mass Spectrometry; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; Nitric Oxide; Nitric Oxide Synthase Type III; Peroxynitrous Acid; Recombinant Proteins; Superoxide Dismutase; Superoxides; Transfection; Tyrosine | 2010 |
The effect of tyrosine nitration of L-type Ca2+ channels on excitation-transcription coupling in colonic inflammation.
Topics: Animals; Blotting, Western; Calcium Channels, L-Type; CHO Cells; Colitis; Cricetinae; Cricetulus; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Excitation Contraction Coupling; Humans; Immunohistochemistry; Immunoprecipitation; Male; Membrane Potentials; Mice; Mice, Inbred BALB C; Muscle, Smooth; Patch-Clamp Techniques; Peroxynitrous Acid; Protein Kinase Inhibitors; Response Elements; Reverse Transcriptase Polymerase Chain Reaction; src-Family Kinases; Transcriptional Activation; Transfection; Tyrosine | 2010 |
Peroxynitrite-mediated oxidative modifications of complex II: relevance in myocardial infarction.
Topics: Amino Acid Sequence; Animals; Cell Hypoxia; Cyclic N-Oxides; Cysteine; Disulfides; Electron Transport Complex II; Flavin-Adenine Dinucleotide; Humans; Molecular Sequence Data; Molecular Weight; Muscle Cells; Myocardial Infarction; Oxidation-Reduction; Peroxynitrous Acid; Protein Subunits; Rats; Rats, Sprague-Dawley; Tyrosine | 2010 |
Lipid peroxyl radicals mediate tyrosine dimerization and nitration in membranes.
Topics: alpha-Tocopherol; Electron Spin Resonance Spectroscopy; Hemin; Lipid Bilayers; Lipid Peroxidation; Nitrogen Dioxide; Oxidation-Reduction; Peroxides; Peroxynitrous Acid; Protein Multimerization; Tyrosine | 2010 |
Physical evidence for substrate binding in preventing cyclooxygenase inactivation under nitrative stress.
Topics: Amino Acid Sequence; Animals; Arachidonic Acid; Catalytic Domain; Chromatography, High Pressure Liquid; Chromatography, Liquid; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Electrochemistry; Enzyme Activation; Heme; Humans; Mice; Molecular Sequence Data; Peroxynitrous Acid; Prostaglandin-Endoperoxide Synthases; Protein Binding; Protein Multimerization; Protein Structure, Quaternary; Rats; Stress, Physiological; Substrate Specificity; Tandem Mass Spectrometry; Tyrosine | 2010 |
Exogenous SOD mimetic tempol ameliorates the early retinal changes reestablishing the redox status in diabetic hypertensive rats.
Topics: Animals; Blotting, Western; Cyclic N-Oxides; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Fibronectins; Glial Fibrillary Acidic Protein; Glutathione; Hypertension; Immunoenzyme Techniques; Male; Neuroprotective Agents; Nitric Oxide Synthase Type II; Oxidation-Reduction; Oxidative Stress; Peroxynitrous Acid; Poly(ADP-ribose) Polymerases; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Spin Labels; Superoxide Dismutase; Tyrosine | 2010 |
Expression of 3-nitrotyrosine, a marker for peroxynitrite, in nasal polyps of nonatopic patients.
Topics: Adult; Epithelium; Female; Free Radicals; Gene Expression Regulation; Humans; Immunohistochemistry; Male; Metaplasia; Models, Biological; Nasal Mucosa; Nasal Polyps; Oxygen; Peroxynitrous Acid; Tyrosine | 2010 |
Peroxynitrite and hemoglobin-mediated nitrative/oxidative modification of human plasma protein: effects of some flavonoids.
Topics: Antioxidants; Blood Proteins; Flavonoids; Free Radical Scavengers; Hemoglobins; Humans; Molecular Structure; Nitrates; Oxidation-Reduction; Peroxynitrous Acid; Tyrosine | 2010 |
Conversion of biliverdin to bilirubin by biliverdin reductase contributes to endothelial cell protection by heme oxygenase-1-evidence for direct and indirect antioxidant actions of bilirubin.
Topics: Angiotensin II; Antioxidants; Bilirubin; Biliverdine; Cytoprotection; Endothelial Cells; Free Radical Scavengers; Gene Knockdown Techniques; Gene Silencing; Heme Oxygenase-1; Humans; Leukocytes; Lipopolysaccharides; Mitochondria; Models, Biological; Neutrophils; Nitrosation; Oxidoreductases Acting on CH-CH Group Donors; Peroxynitrous Acid; Reactive Oxygen Species; Respiratory Burst; Tyrosine; Umbilical Veins; Xanthine Oxidase | 2010 |
Nitrative inactivation of thioredoxin-1 increases vulnerability of diabetic hearts to ischemia/reperfusion injury.
Topics: Animals; Apoptosis; Blood Glucose; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Heart; Hyperglycemia; Immunoblotting; Immunoprecipitation; Mice; Myocardial Reperfusion Injury; Nitrates; Nitrosation; p38 Mitogen-Activated Protein Kinases; Peroxynitrous Acid; Thioredoxins; Tyrosine | 2010 |
Uncoupling of endothelial nitric oxide synthase after experimental subarachnoid hemorrhage.
Topics: Animals; Arterioles; Blotting, Western; Caspase 3; Cerebral Arteries; Fibrinogen; Immunohistochemistry; In Situ Nick-End Labeling; Intracranial Thrombosis; Lac Operon; Mice; Mice, Transgenic; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Peroxynitrous Acid; Subarachnoid Hemorrhage; Superoxides; Tyrosine; Vasospasm, Intracranial | 2011 |
The nitrated proteome in heart mitochondria of the db/db mouse model: characterization of nitrated tyrosine residues in SCOT.
Topics: Animals; Blotting, Western; Chromatography, Liquid; Coenzyme A-Transferases; Diabetes Mellitus; DNA Primers; Electrophoresis, Gel, Two-Dimensional; Escherichia coli; Kinetics; Mice; Mice, Transgenic; Mitochondria, Heart; Mitochondrial Proteins; Mutagenesis, Site-Directed; Nitro Compounds; Peroxynitrous Acid; Proteomics; Receptors, Leptin; Tandem Mass Spectrometry; Tyrosine | 2010 |
Cardiac contractile dysfunction during acute hyperglycemia due to impairment of SERCA by polyol pathway-mediated oxidative stress.
Topics: Acute Disease; Aldehyde Reductase; Animals; Calcium Signaling; Glucose; Glutathione; Heart; Hyperglycemia; In Vitro Techniques; Lactic Acid; Male; Myocardial Contraction; Myocardium; Oxidation-Reduction; Oxidative Stress; Perfusion; Peroxynitrous Acid; Pyruvic Acid; Rats; Rats, Sprague-Dawley; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Signal Transduction; Superoxides; Tyrosine | 2010 |
The role of nitric oxide, superoxide and peroxynitrite in the anti-arrhythmic effects of preconditioning and peroxynitrite infusion in anaesthetized dogs.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Dogs; Female; Infusions, Intra-Arterial; Ischemic Preconditioning, Myocardial; Male; Nitric Oxide; Peroxynitrous Acid; Reactive Nitrogen Species; Superoxides; Tyrosine | 2010 |
Evaluation of the protective effects of Chinese herbs against biomolecule damage induced by peroxynitrite.
Topics: DNA Breaks; Drug Evaluation, Preclinical; Drugs, Chinese Herbal; Fluorescein; Fluorometry; Free Radical Scavengers; Humans; Lipoproteins, LDL; Oxidation-Reduction; Peroxynitrous Acid; Tyrosine | 2010 |
Arachidonic acid inhibits neuronal nitric oxide synthase elicited by proinflammatory stimuli and promotes astrocyte survival with both exogenous and endogenous peroxynitrite via different mechanisms.
Topics: Animals; Animals, Newborn; Arachidonic Acid; Astrocytes; Blotting, Western; Cell Survival; Cells, Cultured; Cerebral Cortex; Enzyme Inhibitors; Immunohistochemistry; Inflammation; Lipoxygenase; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type I; Peroxynitrous Acid; Protein Tyrosine Phosphatases; Rats; Rats, Sprague-Dawley; Signal Transduction; Tyrosine | 2010 |
Melatonin reduces hyperalgesia associated with inflammation.
Topics: Animals; Cyclooxygenase 2; Disease Models, Animal; Hyperalgesia; Immunohistochemistry; Inflammation; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Melatonin; Mitogen-Activated Protein Kinases; NF-kappa B; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Signal Transduction; Superoxides; Tyrosine | 2010 |
Sex differences in nitrosative stress during renal ischemia.
Topics: Acute Kidney Injury; Animals; Antioxidants; Disease Models, Animal; Enzyme Activation; Female; Glomerular Filtration Rate; Kidney Medulla; Male; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Oxidative Stress; Peroxynitrous Acid; Phosphorylation; Protein Multimerization; Rats; Rats, Sprague-Dawley; Reactive Nitrogen Species; Reperfusion Injury; Sex Factors; Sulfhydryl Compounds; Time Factors; Tyrosine | 2010 |
Peroxynitrite mediates right-ventricular dysfunction in nitric oxide-exposed juvenile rats.
Topics: Administration, Inhalation; Animals; Animals, Newborn; Apoptosis; Disease Models, Animal; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Metalloporphyrins; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Rats; Tyrosine; Vascular Resistance; Ventricular Dysfunction, Right | 2010 |
Increased nitration and diminished activity of copper/zinc superoxide dismutase in placentas from diabetic rats.
Topics: Amino Acid Sequence; Animals; Cattle; Diabetes Mellitus, Experimental; Female; Humans; In Vitro Techniques; Male; Molecular Sequence Data; Nitric Oxide; Peroxynitrous Acid; Placenta; Pregnancy; Rats; Rats, Wistar; Sequence Alignment; Streptozocin; Superoxide Dismutase; Tyrosine | 2010 |
eNOS-beta-actin interaction contributes to increased peroxynitrite formation during hyperoxia in pulmonary artery endothelial cells and mouse lungs.
Topics: Actins; Animals; Cells, Cultured; Chlorocebus aethiops; COS Cells; Endothelial Cells; Hyperoxia; Immunoblotting; Lung; Male; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Nitric Oxide; Nitric Oxide Synthase Type III; Oligopeptides; Oxygen; Peroxynitrous Acid; Protein Binding; Pulmonary Artery; RNA Interference; Superoxides; Swine; Tyrosine | 2010 |
L-Carnitine protects plasma components against oxidative alterations.
Topics: Adult; Antioxidants; Blood Proteins; Carnitine; Cysteine; Dietary Supplements; Glutathione; Homocysteine; Humans; Lipid Peroxides; Lipids; Male; Osmolar Concentration; Oxidants; Oxidation-Reduction; Oxidative Stress; Peroxynitrous Acid; Protein Carbonylation; Thiobarbituric Acid Reactive Substances; Tyrosine; Young Adult | 2011 |
Donor pretreatment with tetrahydrobiopterin saves pancreatic isografts from ischemia reperfusion injury in a mouse model.
Topics: Animals; Biopterins; Cold Ischemia; Male; Mice; Mice, Inbred C57BL; Microcirculation; Models, Animal; Pancreas; Pancreas Transplantation; Peroxynitrous Acid; Reperfusion Injury; Tissue Donors; Transplantation, Isogeneic; Tyrosine | 2010 |
Activation of NAD(P)H oxidases by thromboxane A2 receptor uncouples endothelial nitric oxide synthase.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Apoptosis; Biopterins; Bridged Bicyclo Compounds, Heterocyclic; Cattle; Cell Survival; Cells, Cultured; Cyclic GMP; Cytochrome P-450 Enzyme System; Endothelial Cells; Enzyme Activation; Enzyme Inhibitors; Fatty Acids, Unsaturated; Intramolecular Oxidoreductases; Mice; Mice, Inbred C57BL; Mice, Knockout; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Peroxynitrous Acid; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Protein Transport; Receptors, Immunologic; Receptors, Thromboxane A2, Prostaglandin H2; RNA Interference; Signal Transduction; Superoxides; Time Factors; Tyrosine | 2011 |
Glutamoyl diester of the dietary polyphenol curcumin offers improved protection against peroxynitrite-mediated nitrosative stress and damage of brain mitochondria in vitro: implications for Parkinson's disease.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Brain; Curcumin; Diet; Electron Transport Complex I; Esters; Flavonoids; Glutamates; Mice; Mitochondria; Mitochondrial Proteins; Mitochondrial Swelling; Parkinson Disease; Peroxynitrous Acid; Phenols; Polyphenols; Protective Agents; Tyrosine | 2011 |
Inhibition of inducible nitric oxide synthase prevents graft injury after transplantation of livers from rats after cardiac death.
Topics: Alanine Transaminase; Animals; Bilirubin; Death; Enzyme Inhibitors; Graft Rejection; Graft Survival; Imines; Liver; Liver Transplantation; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase 9; Necrosis; Nitrates; Nitric Oxide Synthase Type II; Nitrites; Peroxynitrous Acid; Rats; Rats, Inbred Lew; Reactive Nitrogen Species; Tyrosine | 2010 |
Inhibition of Arabidopsis O-acetylserine(thiol)lyase A1 by tyrosine nitration.
Topics: Amino Acid Sequence; Arabidopsis; Binding Sites; Biocatalysis; Carbon-Oxygen Lyases; Enzyme Inhibitors; Models, Molecular; Mutation; Peroxynitrous Acid; Plant Extracts; Protein Conformation; Protein Processing, Post-Translational; Tyrosine | 2011 |
Apoptosis of hepatic stellate cells mediated by specific protein nitration.
Topics: Animals; Apoptosis; Caspase 3; Caspase 9; Cell Line; DNA Fragmentation; Hepatic Stellate Cells; Humans; Inflammation; Intracellular Signaling Peptides and Proteins; Liver Cirrhosis; Molsidomine; Nitric Oxide; Peroxynitrous Acid; Protein-Tyrosine Kinases; Rats; Signal Transduction; src-Family Kinases; Syk Kinase; Tyrosine | 2011 |
Beneficial pulmonary effects of a metalloporphyrinic peroxynitrite decomposition catalyst in burn and smoke inhalation injury.
Topics: Animals; Burns; Capillary Permeability; Catalysis; Disease Models, Animal; Female; Hemodynamics; Interleukin-8; Lung; Metalloporphyrins; Peroxidase; Peroxynitrous Acid; Poly(ADP-ribose) Polymerases; Pulmonary Circulation; Sheep; Smoke Inhalation Injury; Tyrosine; Vascular Endothelial Growth Factor A | 2011 |
Peroxynitrite mediates active site tyrosine nitration in manganese superoxide dismutase. Evidence of a role for the carbonate radical anion.
Topics: Azides; Biocatalysis; Carbon Dioxide; Carbonates; Catalytic Domain; Escherichia coli; Free Radicals; Models, Molecular; Nitro Compounds; Peroxynitrous Acid; Superoxide Dismutase; Tyrosine | 2010 |
Mass spectrometric identification of tryptophan nitration sites on proteins in peroxynitrite-treated lysates from PC12 cells.
Topics: Amino Acid Sequence; Animals; Cell Extracts; Chromatography, Liquid; Enzymes; HSP90 Heat-Shock Proteins; Models, Molecular; Molecular Sequence Data; PC12 Cells; Peroxynitrous Acid; Protein Structure, Tertiary; Rats; Tandem Mass Spectrometry; Tryptophan; Tyrosine | 2011 |
Peroxynitrite induces HMGB1 release by cardiac cells in vitro and HMGB1 upregulation in the infarcted myocardium in vivo.
Topics: Animals; Apoptosis; Cells, Cultured; HMGB1 Protein; Male; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; Myoblasts, Cardiac; Myocardial Infarction; Necrosis; Peroxynitrous Acid; Rats; Rats, Wistar; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Toll-Like Receptor 4; Tyrosine; Up-Regulation | 2011 |
Nitrosative protein oxidation is modulated during early endotoxemia.
Topics: Animals; Biotin; Blood Pressure; Cysteine; Endotoxemia; Escherichia coli; Heart; HEK293 Cells; Humans; Hypotension; Immunoblotting; In Vitro Techniques; Lipopolysaccharides; Mass Spectrometry; Metalloporphyrins; Mice; Mice, Inbred C57BL; Models, Animal; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Peroxynitrous Acid; Protein Processing, Post-Translational; Proteins; Rats; Rats, Wistar; S-Nitroso-N-Acetylpenicillamine; Sensitivity and Specificity; Sepsis; Signal Transduction; Telemetry; Tyrosine | 2011 |
[Establishment and application of double-antibody sandwich ELISA for determination of 3-nitrotyrosine].
Topics: Animals; Antibodies, Monoclonal; Enzyme-Linked Immunosorbent Assay; Male; Myocardial Reperfusion Injury; Myocardium; Peroxynitrous Acid; Rats; Rats, Wistar; Sensitivity and Specificity; Tyrosine | 2009 |
Peroxynitrite-induced modification of H2A histone presents epitopes which are strongly bound by human anti-DNA autoantibodies: role of peroxynitrite-modified-H2A in SLE induction and progression.
Topics: Antibodies, Antinuclear; Autoantibodies; Chromatography, High Pressure Liquid; Enzyme-Linked Immunosorbent Assay; Epitopes; Histones; Humans; Lupus Erythematosus, Systemic; Nitro Compounds; Peroxynitrous Acid; Tyrosine | 2011 |
Endotoxin mediated-iNOS induction causes insulin resistance via ONOO⁻ induced tyrosine nitration of IRS-1 in skeletal muscle.
Topics: Animals; Endotoxemia; Endotoxins; Insulin Receptor Substrate Proteins; Insulin Resistance; Mice; Muscle, Skeletal; Nitric Oxide Synthase Type II; Nitrogen; Obesity; Peroxynitrous Acid; Phosphatidylinositol 3-Kinases; Rats; Sepsis; Signal Transduction; Tyrosine | 2010 |
Treatment of diabetic rats with a peroxynitrite decomposition catalyst prevents induction of renal COX-2.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Cells, Cultured; Creatinine; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Diabetes Mellitus, Experimental; Dinoprostone; Humans; Kidney; Male; Metalloporphyrins; Peroxynitrous Acid; Rats; Rats, Wistar; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha; Tyrosine | 2011 |
Differential effects of NADPH oxidase and xanthine oxidase inhibition on sympathetic reinnervation in postinfarct rat hearts.
Topics: Acetophenones; Allopurinol; Animals; Arrhythmias, Cardiac; Coronary Vessels; Ethidium; Male; Molsidomine; Myocardial Infarction; Myocardium; NADPH Oxidases; Nerve Growth Factor; Oxidative Stress; Peroxynitrous Acid; Rats; Rats, Wistar; Superoxides; Sympathetic Nervous System; Tyrosine; Xanthine Oxidase | 2011 |
Detection of peroxynitrite accumulation in Arabidopsis thaliana during the hypersensitive defense response.
Topics: Aniline Compounds; Arabidopsis; Bacterial Proteins; Boron Compounds; Fluoresceins; Molsidomine; Nitric Oxide; Peroxynitrous Acid; Photometry; Plant Diseases; Plant Leaves; Protein Processing, Post-Translational; Pseudomonas syringae; Signal Transduction; Tyrosine; Uric Acid | 2011 |
[The correlation of asymmetrical dimethylarginine level and oxidative stress to the onset of Alzheimer's disease].
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Arginine; Female; Humans; Male; Malondialdehyde; Middle Aged; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidative Stress; Peptide Fragments; Peroxynitrous Acid; Reactive Oxygen Species; Tyrosine | 2010 |
The extract from hop cones (Humulus lupulus) as a modulator of oxidative stress in blood platelets.
Topics: Antioxidants; Blood Platelets; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Flavonoids; Humans; Humulus; Lipid Peroxidation; Oxidation-Reduction; Oxidative Stress; Peroxynitrous Acid; Phenols; Plant Extracts; Protein Carbonylation; Resveratrol; Stilbenes; Thiobarbituric Acid Reactive Substances; Tyrosine | 2011 |
Activation of MEK1/ERK1/2/iNOS/sGC/PKG pathway associated with peroxynitrite formation contributes to hypotension and vascular hyporeactivity in endotoxemic rats.
Topics: Animals; Aorta, Thoracic; Blood Pressure; Cyclic GMP-Dependent Protein Kinases; Endotoxemia; Endotoxins; Enzyme Activation; Enzyme Inhibitors; Guanylate Cyclase; Heart Rate; Hypotension; Male; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase 3; Nitric Oxide Synthase Type II; Nitrites; Norepinephrine; Oxidative Stress; Peroxynitrous Acid; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Soluble Guanylyl Cyclase; Tyrosine | 2011 |
Melatonin improves mitochondrial respiratory chain activity and liver morphology in ob/ob mice.
Topics: Animals; Blotting, Western; Body Weight; Electron Transport Chain Complex Proteins; Fatty Liver; Histocytochemistry; Liver; Male; Melatonin; Mice; Mice, Inbred C57BL; Mice, Obese; Mitochondria, Liver; Nitrates; Oxidative Stress; Peroxynitrous Acid; Protein Subunits; Tyrosine | 2011 |
Comparison of fluorescence reagents for simultaneous determination of hydroxylated phenylalanine and nitrated tyrosine by high-performance liquid chromatography with fluorescence detection.
Topics: Chromatography, High Pressure Liquid; Fluorescent Dyes; Humans; Hydrogen Peroxide; Hydrogen-Ion Concentration; Limit of Detection; Peroxynitrous Acid; Phenylalanine; Reproducibility of Results; Solid Phase Extraction; Spectrometry, Fluorescence; Tyrosine | 2012 |
In-channel amperometric detection for microchip electrophoresis using a wireless isolated potentiostat.
Topics: Anions; Ascorbic Acid; Electrophoresis, Microchip; Glutathione; Peroxynitrous Acid; Trimethyl Ammonium Compounds; Tyrosine | 2011 |
Role of superoxide-nitric oxide interactions in the accelerated age-related loss of muscle mass in mice lacking Cu,Zn superoxide dismutase.
Topics: Aging; Animals; Blotting, Western; Carbonic Anhydrase III; Electric Stimulation; Ethidium; Fluoresceins; Fluorescence; Isometric Contraction; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Muscle, Skeletal; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Peroxiredoxins; Peroxynitrous Acid; Reactive Oxygen Species; Superoxide Dismutase; Superoxide Dismutase-1; Superoxides; Tyrosine | 2011 |
Inactivation and reactivation of the mitochondrial α-ketoglutarate dehydrogenase complex.
Topics: Alzheimer Disease; Brain; Cell Line; Citric Acid Cycle; Enzyme Activation; Humans; Ketoglutarate Dehydrogenase Complex; Mitochondria; Mitochondrial Proteins; Peroxynitrous Acid; Tyrosine | 2011 |
Clovamide-rich extract from Trifolium pallidum reduces oxidative stress-induced damage to blood platelets and plasma.
Topics: Adult; Blood Platelets; Blood Proteins; Humans; Lipids; Oxidative Stress; Peroxynitrous Acid; Plant Components, Aerial; Plant Extracts; Plasma; Protein Carbonylation; Thiobarbituric Acid Reactive Substances; Trifolium; Tyrosine; Young Adult | 2011 |
Cytokine toxicity in insulin-producing cells is mediated by nitro-oxidative stress-induced hydroxyl radical formation in mitochondria.
Topics: Animals; Antioxidants; Caspase 3; Cell Line; Clone Cells; Cytokines; Enzyme Inhibitors; Fluoresceins; Hydrogen Peroxide; Hydroxyl Radical; Insulin; Insulin-Secreting Cells; Mitochondria; Nitric Oxide; Nitric Oxide Synthase Type II; Nitrites; Oxidation-Reduction; Oxidative Stress; Peroxynitrous Acid; Rats; Rats, Inbred Lew; Tyrosine | 2011 |
Hypertonic saline and reduced peroxynitrite formation in experimental pancreatitis.
Topics: Alanine Transaminase; Animals; Blotting, Western; Gene Expression; Lipid Peroxidation; Liver; Male; Nitric Oxide Synthase Type II; Oxidative Stress; Pancreatitis; Peroxynitrous Acid; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Saline Solution, Hypertonic; Time Factors; Tyrosine | 2011 |
Generation of novel recombinant antibodies against nitrotyrosine by antibody phage display.
Topics: Amino Acid Sequence; Animals; Antibodies; Antibody Specificity; Antigens; Binding Sites; Biotinylation; Enzyme-Linked Immunosorbent Assay; Humans; Immunoblotting; Immunoconjugates; Mice; Molecular Sequence Data; Peptide Library; Peroxynitrous Acid; Protein Binding; Protein Processing, Post-Translational; Recombinant Proteins; Small Molecule Libraries; Tyrosine | 2011 |
Effect of peptide-based captopril analogues on angiotensin converting enzyme activity and peroxynitrite-mediated tyrosine nitration.
Topics: Captopril; Crystallography, X-Ray; Dipeptides; Enzyme Inhibitors; Models, Molecular; Molecular Structure; Peptidyl-Dipeptidase A; Peroxynitrous Acid; Stereoisomerism; Structure-Activity Relationship; Tyrosine | 2011 |
High temperature triggers the metabolism of S-nitrosothiols in sunflower mediating a process of nitrosative stress which provokes the inhibition of ferredoxin-NADP reductase by tyrosine nitration.
Topics: Aldehyde Oxidoreductases; Arginine; Ferredoxin-NADP Reductase; Gene Expression Regulation, Plant; Helianthus; Hot Temperature; Hypocotyl; Lipid Peroxides; Nitrate Reductase; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Nitrosation; Peroxynitrous Acid; Photosynthesis; Proteomics; S-Nitrosoglutathione; S-Nitrosothiols; Stress, Physiological; Superoxides; Tyrosine | 2011 |
Role of oxidative/nitrative stress in hepatic encephalopathy induced by thioacetamide.
Topics: Animals; Carcinogens; Chromatography, High Pressure Liquid; Hepatic Encephalopathy; Liver; Male; Malondialdehyde; Nitric Oxide; Oxidative Stress; Peroxynitrous Acid; Rats; Rats, Wistar; Reactive Nitrogen Species; Spectrometry, Fluorescence; Stress, Physiological; Superoxide Dismutase; Superoxides; Thioacetamide; Thiobarbituric Acid Reactive Substances; Tyrosine | 2011 |
Is there a trigger role of peroxynitrite in the anti-arrhythmic effect of ischaemic preconditioning and peroxynitrite infusion?
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Arterial Occlusive Diseases; Coronary Vessels; Dogs; Female; Heart Ventricles; Hemodynamics; Hydrogen-Ion Concentration; Infusions, Intra-Arterial; Ischemic Preconditioning, Myocardial; Male; Myocardial Reperfusion Injury; Nitrates; Nitrites; Peroxynitrous Acid; Superoxides; Time Factors; Tyrosine; Uric Acid | 2011 |
Nitrogen dioxide solubility and permeation in lipid membranes.
Topics: Air Pollutants; Animals; Gases; In Vitro Techniques; Membrane Lipids; Models, Biological; Nitro Compounds; Nitrogen Dioxide; Permeability; Peroxynitrous Acid; Reactive Nitrogen Species; Solubility; Solvents; Thermodynamics; Tyrosine | 2011 |
Neuroprotective mechanisms of cerium oxide nanoparticles in a mouse hippocampal brain slice model of ischemia.
Topics: Animals; Apoptosis; Brain Ischemia; Cerium; Disease Models, Animal; Free Radical Scavengers; Hippocampus; Mice; Nanoparticles; Neuroprotective Agents; Nitric Oxide; Oxidative Stress; Peroxynitrous Acid; Superoxides; Tyrosine | 2011 |
Human internal thoracic artery grafts exhibit severe morphological and functional damage and spasmic vasomotion due to oxidative stress.
Topics: Aged; Aldehydes; Analysis of Variance; Female; Histological Techniques; Humans; Immunohistochemistry; Male; Mammary Arteries; Middle Aged; Oxidative Stress; Peroxynitrous Acid; Poly(ADP-ribose) Polymerases; Spasm; Tyrosine; Vascular Grafting; Vasomotor System | 2011 |
Inhibition of peroxynitrite- and peroxidase-mediated protein tyrosine nitration by imidazole-based thiourea and selenourea derivatives.
Topics: Animals; Cattle; Crystallography, X-Ray; Imidazoles; Models, Molecular; Molecular Structure; Nitrates; Organoselenium Compounds; Peroxidase; Peroxynitrous Acid; Serum Albumin, Bovine; Stereoisomerism; Thiourea; Tyrosine; Urea | 2011 |
Nitrocapsanthin and nitrofucoxanthin, respective products of capsanthin and fucoxanthin reaction with peroxynitrite.
Topics: Animals; Anticarcinogenic Agents; Burkitt Lymphoma; Cell Line, Tumor; Female; Free Radical Scavengers; Humans; Mice; Mice, Inbred ICR; Pancreatic Neoplasms; Papilloma; Peroxynitrous Acid; Skin Neoplasms; Tyrosine; Xanthophylls | 2011 |
Nitration of tyrosine 10 critically enhances amyloid β aggregation and plaque formation.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloidosis; Animals; Biophysics; Brain; Disease Models, Animal; Drug Combinations; Electric Stimulation; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Hippocampus; Humans; Immunoprecipitation; In Vitro Techniques; Long-Term Potentiation; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Neurons; Nitric Oxide Synthase Type II; Patch-Clamp Techniques; Peptide Fragments; Peroxynitrous Acid; Plaque, Amyloid; Presenilin-1; Tyrosine | 2011 |
Beetroot betalain inhibits peroxynitrite-mediated tyrosine nitration and DNA strand cleavage.
Topics: Beta vulgaris; Betalains; DNA Breaks; Free Radical Scavengers; Nitrates; Peroxynitrous Acid; Reactive Oxygen Species; Tyrosine | 2012 |
Measurement of 3-nitro-tyrosine in human plasma and urine by gas chromatography-tandem mass spectrometry.
Topics: Gas Chromatography-Mass Spectrometry; Humans; Nitrites; Peroxynitrous Acid; Solubility; Tandem Mass Spectrometry; Tyrosine | 2012 |
Estradiol attenuates high glucose-induced endothelial nitrotyrosine: role for neuronal nitric oxide synthase.
Topics: Diabetes Mellitus; Endothelium, Vascular; Enzyme Inhibitors; Estradiol; Female; Glucose; Human Umbilical Vein Endothelial Cells; Humans; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Oxidation-Reduction; Oxidative Stress; Peroxynitrous Acid; Signal Transduction; Superoxides; Tyrosine | 2012 |
Investigation of local primary structure effects on peroxynitrite-mediated tyrosine nitration using targeted mass spectrometry.
Topics: Amino Acid Sequence; Molecular Sequence Data; Oligopeptides; Peroxynitrous Acid; Protein Processing, Post-Translational; Proteins; Serum Albumin, Bovine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tyrosine | 2012 |
Ouabain increases iNOS-dependent nitric oxide generation which contributes to the hypertrophic effect of the glycoside: possible role of peroxynitrite formation.
Topics: Animals; Cardiotonic Agents; Cell Shape; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Induction; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Hypertrophy, Left Ventricular; L-Lactate Dehydrogenase; Male; Myocytes, Cardiac; Nitric Oxide; Nitric Oxide Synthase Type II; Ouabain; p38 Mitogen-Activated Protein Kinases; Peroxynitrous Acid; Phosphorylation; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction; Superoxides; Time Factors; Tyrosine; Up-Regulation | 2012 |
Protein tyrosine nitration of 15-hydroxy prostaglandin dehydrogenase in the human mast cell line LAD2.
Topics: Cell Line; Humans; Hydroxyprostaglandin Dehydrogenases; Mast Cells; Nitric Oxide; Nitric Oxide Donors; Peroxynitrous Acid; Protein Processing, Post-Translational; S-Nitrosoglutathione; Tyrosine | 2012 |
Tyrosine nitration of PA700 links proteasome activation to endothelial dysfunction in mouse models with cardiovascular risk factors.
Topics: Animals; Blotting, Western; Cardiovascular Diseases; Cells, Cultured; Cysteine Proteinase Inhibitors; Diabetes Mellitus, Experimental; Dyslipidemias; Endothelium, Vascular; Enzyme Activation; Human Umbilical Vein Endothelial Cells; Humans; Hypertension; Leupeptins; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitrosation; Peroxynitrous Acid; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Subunits; Receptors, LDL; Risk Factors; RNA Interference; Thioredoxins; Tyrosine | 2012 |
Rapid and sensitive determination of protein-nitrotyrosine by ELISA: Application to human plasma.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Animals; Blood Proteins; Cattle; Detergents; Enzyme-Linked Immunosorbent Assay; Female; Humans; Limit of Detection; Middle Aged; Obesity; Oxidation-Reduction; Peroxynitrous Acid; Plasma; Polysorbates; Preservation, Biological; Protein Stability; Reference Standards; Sensitivity and Specificity; Serum; Serum Albumin, Bovine; Temperature; Time Factors; Tyrosine; Young Adult | 2012 |
Chronic hypoxia increases peroxynitrite, MMP9 expression, and collagen accumulation in fetal guinea pig hearts.
Topics: Acetylcysteine; Animals; Body Weight; Collagen; Female; Fetal Heart; Guinea Pigs; Hypoxia; Lipid Peroxidation; Matrix Metalloproteinase 9; Nitric Oxide Synthase Type II; Organ Size; Peroxynitrous Acid; Pregnancy; Tyrosine | 2012 |
A non-damaging method to analyze the configuration and dynamics of nitrotyrosines in proteins.
Topics: Cytochromes c; Nitrates; Nuclear Magnetic Resonance, Biomolecular; Peroxynitrous Acid; Proteins; Tyrosine | 2012 |
Catalytic peroxynitrite decomposition improves reperfusion injury after heart transplantation.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Biomarkers; Coronary Circulation; Disease Models, Animal; Endothelium, Vascular; Energy Metabolism; Heart Transplantation; Immunohistochemistry; Male; Metalloporphyrins; Myocardial Reperfusion Injury; Myocardium; Oxidative Stress; Peroxynitrous Acid; Poly Adenosine Diphosphate Ribose; Rats; Rats, Inbred Lew; Time Factors; Tyrosine; Vasodilation; Ventricular Function, Left; Ventricular Pressure | 2012 |
Protein tyrosine nitration of mitochondrial carbamoyl phosphate synthetase 1 and its functional consequences.
Topics: Allosteric Regulation; Amino Acid Sequence; Animals; Carbamoyl-Phosphate Synthase (Ammonia); Mice; Mitochondria, Liver; Mitochondrial Proteins; Models, Molecular; Molecular Sequence Data; Nitrates; Peroxynitrous Acid; Protein Structure, Secondary; Protein Structure, Tertiary; Tyrosine | 2012 |
The expression of iNOS and nitrotyrosine in colitis and colon cancer in humans.
Topics: Colitis; Colonic Neoplasms; HT29 Cells; Humans; Immunohistochemistry; NF-kappa B; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Real-Time Polymerase Chain Reaction; Tumor Cells, Cultured; Tyrosine | 2012 |
Cerebral myogenic reactivity and blood flow in type 2 diabetic rats: role of peroxynitrite in hypoxia-mediated loss of myogenic tone.
Topics: Actins; Animals; Cell Hypoxia; Cerebrovascular Circulation; Diabetes Mellitus, Type 2; Disease Models, Animal; Hyperemia; Male; Metalloporphyrins; Middle Cerebral Artery; Muscle, Smooth, Vascular; Peroxynitrous Acid; Rats; Rats, Wistar; Tyrosine | 2012 |
Identification of nitration sites by peroxynitrite on p16 protein.
Topics: Amino Acid Sequence; Chromatography, High Pressure Liquid; Cyclin-Dependent Kinase Inhibitor p16; Electrophoresis, Polyacrylamide Gel; Humans; Molecular Sequence Data; Nitrates; Peroxynitrous Acid; Recombinant Proteins; Sequence Analysis, Protein; Tandem Mass Spectrometry; Tyrosine | 2012 |
Oxidative damage to pre-eclamptic placenta: immunohistochemical expression of VEGF, nitrotyrosine residues and von Willebrand factor.
Topics: Adult; Case-Control Studies; Endothelium, Vascular; Female; Humans; Immunohistochemistry; Oxidative Stress; Peroxynitrous Acid; Placenta; Pre-Eclampsia; Pregnancy; Tissue Distribution; Trophoblasts; Tyrosine; Vascular Endothelial Growth Factor A; von Willebrand Factor | 2012 |
ACE2 deficiency enhances angiotensin II-mediated aortic profilin-1 expression, inflammation and peroxynitrite production.
Topics: Angiotensin II; Angiotensin-Converting Enzyme 2; Animals; Aorta; Blotting, Western; Chemokine CCL2; Ethidium; Inflammation; Interleukin-1beta; Interleukin-6; Mice; Mice, Knockout; NADPH Oxidases; Peptidyl-Dipeptidase A; Peroxynitrous Acid; Profilins; Real-Time Polymerase Chain Reaction; Tyrosine | 2012 |
Antioxidant protects against increases in low molecular weight hyaluronan and inflammation in asphyxiated newborn pigs resuscitated with 100% oxygen.
Topics: Acetylcysteine; Analysis of Variance; Animals; Animals, Newborn; Antioxidants; Asphyxia; Bronchoalveolar Lavage; DNA Primers; Enzyme-Linked Immunosorbent Assay; Hyaluronic Acid; Interleukin-1beta; Lung; Oxidative Stress; Oxygen Inhalation Therapy; Peroxynitrous Acid; Real-Time Polymerase Chain Reaction; Sus scrofa; Tumor Necrosis Factor-alpha; Tyrosine | 2012 |
Tyrosine nitration of voltage-dependent anion channels in cardiac ischemia-reperfusion: reduction by peroxynitrite scavenging.
Topics: Animals; Guinea Pigs; Mass Spectrometry; Mitochondrial Proteins; Myocardial Reperfusion Injury; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Peroxynitrous Acid; Resveratrol; Stilbenes; Superoxides; Tyrosine; Voltage-Dependent Anion Channels | 2012 |
Cigarette smoke and LDL cooperate in reducing nitric oxide bioavailability in endothelial cells via effects on both eNOS and NADPH oxidase.
Topics: Biological Availability; Human Umbilical Vein Endothelial Cells; Humans; Lipoproteins, LDL; Male; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Peroxynitrous Acid; RNA, Messenger; RNA, Small Interfering; Tobacco Smoke Pollution; Tyrosine | 2012 |
Enhancement of 26S proteasome functionality connects oxidative stress and vascular endothelial inflammatory response in diabetes mellitus.
Topics: Animals; Blood Glucose; Cells, Cultured; Cysteine Proteinase Inhibitors; Diabetes Mellitus, Experimental; Endothelium, Vascular; Enzyme Activation; Free Radical Scavengers; Gene Expression Regulation; Green Fluorescent Proteins; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Inflammation Mediators; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; NF-kappa B; Oxidative Stress; Peroxynitrous Acid; Proteasome Endopeptidase Complex; Proteasome Inhibitors; RNA Interference; Time Factors; Tyrosine; Ubiquitination | 2012 |
Acute O-GlcNAcylation prevents inflammation-induced vascular dysfunction.
Topics: Acetylglucosamine; Acylation; Animals; Aorta, Thoracic; Aortic Diseases; beta-N-Acetylhexosaminidases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Immunohistochemistry; Inflammation; Inflammation Mediators; Male; Myography; Nitric Oxide Synthase Type II; Oxidative Stress; Peroxynitrous Acid; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; Time Factors; Tissue Culture Techniques; Tumor Necrosis Factor-alpha; Tyrosine; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2012 |
Fine tuning the reactivity of corrole-based catalytic antioxidants.
Topics: Antioxidants; Catalysis; Electrochemical Techniques; Kinetics; Manganese; Metalloporphyrins; Molecular Structure; Oxidation-Reduction; Peroxynitrous Acid; Porphyrins; Spectrum Analysis; Structure-Activity Relationship; Superoxide Dismutase; Thermodynamics; Tyrosine; Water | 2012 |
Anti-oxidative, anti-tumor-promoting, and anti-carcinogensis activities of nitroastaxanthin and nitrolutein, the reaction products of astaxanthin and lutein with peroxynitrite.
Topics: Animals; Anticarcinogenic Agents; Antigens, Viral; Antineoplastic Agents; Antioxidants; Cell Transformation, Neoplastic; Female; Lutein; Mice; Mice, Inbred ICR; Papilloma; Peroxynitrous Acid; Skin Neoplasms; Tyrosine; Xanthophylls | 2012 |
Supraspinal peroxynitrite modulates pain signaling by suppressing the endogenous opioid pathway.
Topics: Analysis of Variance; Animals; Carrageenan; CD11b Antigen; Cell Line, Transformed; Chromatography, Liquid; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Electrochemical Techniques; Enkephalin, Methionine; Glial Fibrillary Acidic Protein; Humans; Hyperalgesia; Injections, Spinal; Male; Medulla Oblongata; Metalloporphyrins; Microinjections; Neuroglia; Neurons; Opioid Peptides; Pain; Pain Measurement; Peroxynitrous Acid; Phosphopyruvate Hydratase; Protein Binding; Radioligand Assay; Rats; Rats, Sprague-Dawley; Signal Transduction; Tyrosine | 2012 |
Reactive nitrogen oxide species-induced post-translational modifications in human hemoglobin and the association with cigarette smoking.
Topics: Amino Acid Sequence; Chromatography, High Pressure Liquid; Cysteine; Hemoglobins; Humans; Methionine; Molecular Sequence Data; Oxidation-Reduction; Peptides; Peroxynitrous Acid; Protein Processing, Post-Translational; Reactive Nitrogen Species; Smoking; Spectrometry, Mass, Electrospray Ionization; Sulfinic Acids; Tyrosine | 2012 |
Relationship of nitric oxide synthase induction to peroxynitrite-mediated oxidative damage during the first week after experimental traumatic brain injury.
Topics: Analysis of Variance; Animals; Brain; Brain Injuries; Disease Models, Animal; Functional Laterality; Gene Expression Regulation; Mice; Nitric Oxide Synthase; Oxidative Stress; Peroxynitrous Acid; Protein Isoforms; RNA, Messenger; Time Factors; Tyrosine | 2012 |
Role of peroxynitrite-modified H2A histone in the induction and progression of rheumatoid arthritis.
Topics: Adult; Arthritis, Rheumatoid; Autoantibodies; C-Reactive Protein; Disease Progression; Histones; Humans; Immunoglobulin G; Peroxynitrous Acid; Rheumatoid Factor; Tyrosine | 2012 |
Reaction of human cytochrome P450 3A4 with peroxynitrite: nitrotyrosine formation on the proximal side impairs its interaction with NADPH-cytochrome P450 reductase.
Topics: Cytochrome P-450 CYP3A; Dithionite; Humans; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Peptides; Peroxynitrous Acid; Protein Conformation; Tyrosine | 2012 |
The inhibitory effect of S-nitrosoglutathione on blood-brain barrier disruption and peroxynitrite formation in a rat model of experimental stroke.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Edema; Carrier Proteins; Disease Models, Animal; E-Selectin; Endothelial Cells; Evans Blue; Functional Laterality; Infarction, Middle Cerebral Artery; Male; Matrix Metalloproteinase 9; Neoplasm Proteins; Neurons; Neuroprotective Agents; NF-kappaB-Inducing Kinase; Nitric Oxide; Nitrites; Nucleocytoplasmic Transport Proteins; Peroxynitrous Acid; Phosphopyruvate Hydratase; Protein Serine-Threonine Kinases; Protein Transport; Rats; Rats, Sprague-Dawley; S-Nitrosoglutathione; Statistics, Nonparametric; Time Factors; Tyrosine; Zonula Occludens-1 Protein | 2012 |
Microwave-assisted synthesis of hydroxyphenyl nitrones with protective action against oxidative stress.
Topics: Anti-Inflammatory Agents; Antioxidants; Blood-Brain Barrier; Cell Survival; Dose-Response Relationship, Drug; Humans; Microwaves; Molecular Structure; Neuroblastoma; Neuroprotective Agents; Nitrogen Oxides; Oxidative Stress; Oxidopamine; Peroxynitrous Acid; Structure-Activity Relationship; Tyrosine | 2012 |
Neuroprotective effects of Cyperus rotundus on SIN-1 induced nitric oxide generation and protein nitration: ameliorative effect against apoptosis mediated neuronal cell damage.
Topics: Apoptosis; Blotting, Western; Caspase 3; Catalase; Cell Death; Cell Line, Tumor; Cyperus; Cytoprotection; DNA Damage; Dose-Response Relationship, Drug; HSP70 Heat-Shock Proteins; Humans; Lipid Peroxidation; Molsidomine; Neurons; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Plant Extracts; Plants, Medicinal; Proto-Oncogene Proteins c-bcl-2; Rhizome; Superoxide Dismutase; Tyrosine | 2013 |
Catalpol decreases peroxynitrite formation and consequently exerts cardioprotective effects against ischemia/reperfusion insult.
Topics: Animals; Antioxidants; Apoptosis; Cardiotonic Agents; Disease Models, Animal; Down-Regulation; Enzyme Activation; Free Radical Scavengers; Injections, Intraperitoneal; Iridoid Glucosides; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Necrosis; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Peroxynitrous Acid; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Time Factors; Tyrosine | 2013 |
Protein tyrosine nitration in pea roots during development and senescence.
Topics: Cell Death; Cytosol; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Enzyme Assays; Isocitrate Dehydrogenase; Isoenzymes; Microscopy, Confocal; Nitric Oxide; Oxidation-Reduction; Oxidative Stress; Peroxynitrous Acid; Pisum sativum; Plant Roots; Plant Stems; Proteome; Superoxide Dismutase; Time Factors; Tyrosine | 2013 |
Nitration of Hsp90 induces cell death.
Topics: Amyotrophic Lateral Sclerosis; Animals; Cell Death; Disease Models, Animal; fas Receptor; HSP90 Heat-Shock Proteins; Humans; Motor Neurons; Peroxynitrous Acid; Protein Processing, Post-Translational; Rats; Spinal Cord Injuries; Tyrosine | 2013 |
Protein tyrosine nitration and thiol oxidation by peroxynitrite-strategies to prevent these oxidative modifications.
Topics: Animals; Cattle; Cytochrome P-450 Enzyme System; Humans; Intramolecular Oxidoreductases; Oxidation-Reduction; Peroxynitrous Acid; Protein Processing, Post-Translational; Sf9 Cells; Spodoptera; Sulfhydryl Compounds; Tyrosine | 2013 |
Endothelial NO and O₂·⁻ production rates differentially regulate oxidative, nitroxidative, and nitrosative stress in the microcirculation.
Topics: Computer Simulation; Endothelial Cells; Endothelium, Vascular; Humans; Microcirculation; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidation-Reduction; Oxidative Stress; Oxygen; Peroxynitrous Acid; Superoxide Dismutase; Superoxides; Tyrosine | 2013 |
Peroxynitrite induced structural changes result in the generation of neo-epitopes on human serum albumin.
Topics: Animals; Electrophoresis, Polyacrylamide Gel; Epitopes; Female; Humans; Immunoglobulin G; Injections, Intramuscular; Nitrates; Oxidation-Reduction; Peroxynitrous Acid; Protein Carbonylation; Protein Conformation; Rabbits; Serum Albumin; Spectroscopy, Fourier Transform Infrared; Tyrosine | 2013 |
Antioxidative effects of extracts from Trifolium species on blood platelets exposed to oxidative stress.
Topics: Antioxidants; Blood Platelets; Cells, Cultured; Humans; Hydrogen Peroxide; Lipid Peroxidation; Oxidants; Oxidative Stress; Peroxynitrous Acid; Plant Components, Aerial; Plant Extracts; Thiobarbituric Acid Reactive Substances; Trifolium; Tyrosine | 2013 |
Inhibition of peroxisomal hydroxypyruvate reductase (HPR1) by tyrosine nitration.
Topics: Amino Acid Sequence; Arabidopsis; Evolution, Molecular; Glutathione; Hydrogen Peroxide; Hydroxypyruvate Reductase; Models, Molecular; Molecular Sequence Data; Nitrates; Oxidation-Reduction; Peroxisomes; Peroxynitrous Acid; Pisum sativum; Plant Leaves; Proteome; Tyrosine | 2013 |
Peroxynitrite is a key mediator of the cardioprotection afforded by ischemic postconditioning in vivo.
Topics: Animals; Cardiotonic Agents; Cytoprotection; Heart; Ischemic Postconditioning; Male; Metalloporphyrins; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Peroxynitrous Acid; Rats; Rats, Wistar; Tyrosine | 2013 |
Determination of nitration degrees for the birch pollen allergen Bet v 1.
Topics: Antigens, Plant; Betula; Calibration; Chromatography, High Pressure Liquid; Peroxynitrous Acid; Plant Proteins; Pollen; Protein Processing, Post-Translational; Recombinant Proteins; Tyrosine | 2013 |
Methylglyoxal modulates endothelial nitric oxide synthase-associated functions in EA.hy926 endothelial cells.
Topics: Antioxidants; Biopterins; Cell Line; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Inhibitors; Humans; Nitric Oxide Synthase Type III; Peroxynitrous Acid; Phosphorylation; Protein Multimerization; Pyruvaldehyde; Superoxides; Time Factors; Tyrosine | 2013 |
Studies on peroxynitrite-modified H1 histone: implications in systemic lupus erythematosus.
Topics: Anilino Naphthalenesulfonates; Animals; Antibodies, Antinuclear; Antigen-Antibody Complex; Autoantibodies; Cross Reactions; Electrophoretic Mobility Shift Assay; Enzyme-Linked Immunosorbent Assay; Female; Fluorescent Dyes; Histones; Humans; Immunization; Immunoglobulin G; Lupus Erythematosus, Systemic; Peroxynitrous Acid; Rabbits; Tyrosine | 2014 |
Capacity of HSYA to inhibit nitrotyrosine formation induced by focal ischemic brain injury.
Topics: Animals; Brain Ischemia; Chalcone; Gene Expression; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Quinones; Rats; Rats, Sprague-Dawley; Tyrosine | 2013 |
Effects of Mn (II) on peroxynitrite nitrifying fibrinogen.
Topics: Animals; Blood Coagulation; Blood Coagulation Tests; Cattle; Electrophoresis, Polyacrylamide Gel; Fibrinogen; Glycoproteins; Manganese; Nitrogen; Peroxynitrous Acid; Spectrometry, Fluorescence; Thrombin; Time Factors; Tyrosine | 2014 |
Dual regulation of cytosolic ascorbate peroxidase (APX) by tyrosine nitration and S-nitrosylation.
Topics: Amino Acid Sequence; Amino Acids; Ascorbate Peroxidases; Chromatography, Liquid; Cytosol; Electrophoresis, Polyacrylamide Gel; Hydrogen Peroxide; Lipid Peroxidation; Mass Spectrometry; Models, Molecular; Molecular Sequence Data; Nitrosation; Oxidative Stress; Peptides; Peroxynitrous Acid; Pisum sativum; Plant Proteins; Protein Multimerization; Recombinant Proteins; S-Nitrosoglutathione; Sodium Chloride; Stress, Physiological; Tyrosine | 2014 |
Contribution of RhoA/Rho-kinase/MEK1/ERK1/2/iNOS pathway to ischemia/reperfusion-induced oxidative/nitrosative stress and inflammation leading to distant and target organ injury in rats.
Topics: Amides; Animals; Catalase; Glutathione; Inflammation; Kidney; Male; Malondialdehyde; MAP Kinase Kinase 1; MAP Kinase Signaling System; Muscle, Skeletal; NADPH Oxidases; Nitric Oxide Synthase Type II; Oxidative Stress; Peroxidase; Peroxynitrous Acid; Pyridines; Rats; Rats, Wistar; Reperfusion Injury; rho-Associated Kinases; rhoA GTP-Binding Protein; Superoxide Dismutase; Tyrosine | 2014 |
Peroxynitrite disrupts endothelial caveolae leading to eNOS uncoupling and diminished flow-mediated dilation in coronary arterioles of diabetic patients.
Topics: Aged; Animals; Arterioles; beta-Cyclodextrins; Caveolae; Caveolin 1; Cells, Cultured; Diabetes Mellitus; Endothelial Cells; Endothelium, Vascular; Female; Humans; Male; Mice; Mice, Knockout; Middle Aged; Nitric Oxide; Nitric Oxide Synthase Type III; Peroxynitrous Acid; Pterins; Regional Blood Flow; Tyrosine; Vasodilation | 2014 |
Requirement of NOX2 expression in both retina and bone marrow for diabetes-induced retinal vascular injury.
Topics: Animals; Blood-Retinal Barrier; Bone Marrow; Cell Adhesion; Chimera; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Gene Expression; Genotype; Intercellular Adhesion Molecule-1; Leukocyte Common Antigens; Leukocytes; Male; Membrane Glycoproteins; Mice; Mice, Knockout; NADPH Oxidase 2; NADPH Oxidases; Oxidative Stress; Peroxynitrous Acid; Retina; Tyrosine; Vascular Endothelial Growth Factor A | 2013 |
Identification of nitrated tyrosine residues of protein kinase G-Iα by mass spectrometry.
Topics: Animals; Baculoviridae; Cyclic GMP-Dependent Protein Kinase Type I; Gene Expression; Humans; Kinetics; Mutation; Nitrates; Nitric Oxide; Peptide Fragments; Peroxynitrous Acid; Phenylalanine; Recombinant Proteins; Sf9 Cells; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spodoptera; Tandem Mass Spectrometry; Trypsin; Tyrosine | 2014 |
Nitration of tyrosine 247 inhibits protein kinase G-1α activity by attenuating cyclic guanosine monophosphate binding.
Topics: Adult; Animals; Aorta; Cardiovascular Diseases; Catalytic Domain; Cell Differentiation; Cell Proliferation; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinase Type I; Female; HEK293 Cells; Humans; Male; Mass Spectrometry; Middle Aged; Models, Molecular; Myocytes, Smooth Muscle; Nitrogen; Peroxynitrous Acid; Protein Binding; Sheep; Tyrosine; Young Adult | 2014 |
Nitration of the birch pollen allergen Bet v 1.0101: efficiency and site-selectivity of liquid and gaseous nitrating agents.
Topics: Amino Acid Sequence; Antigens, Plant; Betula; Escherichia coli; Gene Expression; Kinetics; Models, Molecular; Molecular Sequence Data; Nitrogen Dioxide; Ozone; Peptides; Peroxynitrous Acid; Pollen; Protein Structure, Secondary; Recombinant Proteins; Tetranitromethane; Tyrosine | 2014 |
Structural and molecular basis of the peroxynitrite-mediated nitration and inactivation of Trypanosoma cruzi iron-superoxide dismutases (Fe-SODs) A and B: disparate susceptibilities due to the repair of Tyr35 radical by Cys83 in Fe-SODB through intramolec
Topics: Animals; Binding Sites; Blotting, Western; Catalytic Domain; Chagas Disease; Crystallography, X-Ray; Cysteine; Electron Spin Resonance Spectroscopy; Electron Transport; Enzyme Activation; Host-Parasite Interactions; Isoenzymes; Kinetics; Models, Molecular; Molecular Dynamics Simulation; Mutagenesis, Site-Directed; Nitrates; Peroxynitrous Acid; Protein Binding; Protein Structure, Secondary; Protozoan Proteins; Reactive Oxygen Species; Superoxide Dismutase; Trypanosoma cruzi; Tyrosine | 2014 |
Caffeic acid phenethyl ester (CAPE): scavenger of peroxynitrite in vitro and in sepsis models.
Topics: Animals; Caffeic Acids; Cells, Cultured; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Free Radical Scavengers; Interferon-gamma; Lipopolysaccharides; Macrophage Activation; Macrophages; Male; Mice, Inbred BALB C; Nitric Oxide; Peroxynitrous Acid; Phenylethyl Alcohol; Sepsis; Tyrosine | 2014 |
Low serum ferroxidase I activity is associated with mortality in heart failure and related to both peroxynitrite-induced cysteine oxidation and tyrosine nitration of ceruloplasmin.
Topics: Aged; Aged, 80 and over; Biomarkers; C-Reactive Protein; Case-Control Studies; Ceruloplasmin; Cohort Studies; Cysteine; Female; Follow-Up Studies; Heart Failure; Humans; Male; Natriuretic Peptide, Brain; Norepinephrine; Oxidation-Reduction; Peroxynitrous Acid; Prognosis; Proportional Hazards Models; Survival Rate; Tyrosine | 2014 |
Nitration transforms a sensitive peroxiredoxin 2 into a more active and robust peroxidase.
Topics: Animals; Catalytic Domain; Echinococcus granulosus; Enzyme Activation; Erythrocytes; Escherichia coli; Escherichia coli Proteins; Homeodomain Proteins; Humans; Hydrogen Peroxide; Nitrogen; Oxidation-Reduction; Oxidative Stress; Peroxynitrous Acid; Protein Processing, Post-Translational; Protein Structure, Tertiary; Recombinant Proteins; Signal Transduction; Thioredoxins; Tyrosine | 2014 |
Microchip electrophoresis with amperometric detection method for profiling cellular nitrosative stress markers.
Topics: Animals; Cell Line; Electrophoresis, Microchip; Equipment Design; Glutathione; Hydrogen Peroxide; Macrophages; Mice; Nitric Oxide; Nitrites; Oxidation-Reduction; Peroxynitrous Acid; Tyrosine | 2014 |
Evaluation of a method for nitrotyrosine site identification and relative quantitation using a stable isotope-labeled nitrated spike-in standard and high resolution fourier transform MS and MS/MS analysis.
Topics: Angiotensin I; Animals; Cattle; Cell Line; Chromatography, High Pressure Liquid; Fourier Analysis; Isotope Labeling; Mass Spectrometry; Nitrogen Isotopes; Peroxynitrous Acid; Rats; Serum Albumin, Bovine; Tandem Mass Spectrometry; Tyrosine | 2014 |
Blood-brain barrier disruption induced by hemoglobin in vivo: Involvement of up-regulation of nitric oxide synthase and peroxynitrite formation.
Topics: Analysis of Variance; Animals; Blood-Brain Barrier; Brain Edema; Cerebral Hemorrhage; Claudin-5; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Hemoglobins; Male; Motor Activity; Nitric Oxide; Nitric Oxide Synthase; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Time Factors; Tyrosine; Up-Regulation; Zonula Occludens-1 Protein | 2014 |
Copper futures: ceruloplasmin and heart failure.
Topics: Ceruloplasmin; Cysteine; Female; Heart Failure; Humans; Male; Peroxynitrous Acid; Tyrosine | 2014 |
Tyrosine nitration in peptides by peroxynitrite generated in situ in a light-controlled platform: effects of pH and thiols.
Topics: Carbon Dioxide; Glutathione; Hydrogen-Ion Concentration; Light; Peroxynitrous Acid; Sulfhydryl Compounds; Tyrosine | 2014 |
Protection against peroxynitrite reactions by flavonoids.
Topics: Antioxidants; Flavonoids; Nitrates; Oxidation-Reduction; Peroxynitrous Acid; Tyrosine | 2014 |
ONOOH does not react with H2: Potential beneficial effects of H2 as an antioxidant by selective reaction with hydroxyl radicals and peroxynitrite.
Topics: Antioxidants; Hydrogen; Hydroxyl Radical; Oxidation-Reduction; Oxidative Stress; Peroxynitrous Acid; Tyrosine | 2014 |
Detection of in vivo protein tyrosine nitration in petite mutant of Saccharomyces cerevisiae: consequence of its formation and significance.
Topics: Peroxynitrous Acid; Protein Processing, Post-Translational; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Tyrosine | 2014 |
Mitochondrial DNA acquires immunogenicity on exposure to nitrosative stress in patients with vitiligo.
Topics: Adolescent; Adult; Autoantibodies; Autoimmune Diseases; Autoimmunity; Child; DNA, Mitochondrial; Female; Humans; Immunoglobulin G; Male; Mitochondria; Nitric Oxide; Nitric Oxide Synthase; Nitrosation; Peroxynitrous Acid; Tyrosine; Vitiligo; Young Adult | 2014 |
Differential inhibition of Arabidopsis superoxide dismutases by peroxynitrite-mediated tyrosine nitration.
Topics: Amino Acid Sequence; Arabidopsis; Peroxynitrous Acid; Plant Proteins; Sequence Alignment; Superoxide Dismutase; Tyrosine | 2015 |
Nitric oxide availability is increased in contracting skeletal muscle from aged mice, but does not differentially decrease muscle superoxide.
Topics: Aging; Animals; Blotting, Western; Cells, Cultured; Cytosol; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Mitochondria; Mitochondria, Muscle; Muscle Contraction; Muscle Fibers, Skeletal; Muscle, Skeletal; Nitric Oxide; Peroxiredoxins; Peroxynitrous Acid; Superoxides; Tyrosine | 2015 |
The impact of calcium ion on structure and aggregation propensity of peroxynitrite-modified lens crystallins: new insights into the pathogenesis of cataract disorders.
Topics: Animals; Benzothiazoles; Calcium; Cattle; Crystallins; Hydrophobic and Hydrophilic Interactions; Lens, Crystalline; Oxidants; Peroxynitrous Acid; Protein Aggregates; Protein Carbonylation; Protein Stability; Proteolysis; Spectrometry, Fluorescence; Thiazoles; Tryptophan; Tyrosine | 2015 |
Interaction between hydrogen sulfide-induced sulfhydration and tyrosine nitration in the KATP channel complex.
Topics: Animals; Calcium Chloride; CHO Cells; Cricetulus; Cysteine; Dose-Response Relationship, Drug; Ileum; KATP Channels; Mice; Molsidomine; Muscle Contraction; Muscle, Smooth; Mutation; Peroxynitrous Acid; Protein Processing, Post-Translational; Signal Transduction; Sulfides; Sulfonylurea Receptors; Transfection; Tyrosine | 2015 |
Leghemoglobin is nitrated in functional legume nodules in a tyrosine residue within the heme cavity by a nitrite/peroxide-dependent mechanism.
Topics: Glycine max; Heme; Hydrogen Peroxide; Leghemoglobin; Nitrates; Nitric Oxide; Nitrites; Nitrogen Dioxide; Oxidative Stress; Peroxynitrous Acid; Phaseolus; Protein Processing, Post-Translational; Tyrosine | 2015 |
Preparation of hydrophilic C60(OH)10/2-hydroxypropyl-β-cyclodextrin nanoparticles for the treatment of a liver injury induced by an overdose of acetaminophen.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Acetaminophen; Animals; Antioxidants; Benzothiazoles; beta-Cyclodextrins; Biphenyl Compounds; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Drug Overdose; Electron Spin Resonance Spectroscopy; Free Radical Scavengers; Fullerenes; Glutathione; Hydrophobic and Hydrophilic Interactions; Hydroxylation; Liver; Male; Mice, Inbred C57BL; Nanoparticles; Nitric Oxide; Oxidative Stress; Particle Size; Peroxynitrous Acid; Picrates; Protective Agents; Solubility; Static Electricity; Sulfonic Acids; Tyrosine | 2015 |
Myeloperoxidase scavenges peroxynitrite: A novel anti-inflammatory action of the heme enzyme.
Topics: Aniline Compounds; Anti-Inflammatory Agents; Catechin; Fluoresceins; Halogenation; Humans; Hydrogen Peroxide; Hydrogen-Ion Concentration; Kinetics; Molsidomine; Nitrites; Oxidants; Oxidation-Reduction; Peroxidase; Peroxynitrous Acid; Tyrosine | 2015 |
Protective effect of molecular hydrogen against oxidative stress caused by peroxynitrite derived from nitric oxide in rat retina.
Topics: Animals; Apoptosis; Cell Survival; Hydrogen; In Situ Nick-End Labeling; Male; Membrane Potential, Mitochondrial; Neuroprotective Agents; Nitric Oxide; Nitrosation; Organ Culture Techniques; Oxidative Stress; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Retina; S-Nitroso-N-Acetylpenicillamine; Tyrosine | 2015 |
Resveratrol prevents protein nitration and release of endonucleases from mitochondria during acetaminophen hepatotoxicity.
Topics: Acetaminophen; Animals; Apoptosis Inducing Factor; Chemical and Drug Induced Liver Injury; DNA Fragmentation; Drug Overdose; Endonucleases; Hepatocytes; JNK Mitogen-Activated Protein Kinases; Liver; Male; Mice; Mice, Inbred C57BL; Mitochondria; Oxidative Stress; Peroxynitrous Acid; Protein Binding; Resveratrol; Stilbenes; Tyrosine | 2015 |
TPEN prevents rapid pacing-induced calcium overload and nitration stress in HL-1 myocytes.
Topics: Animals; Apoptosis; Atrial Fibrillation; Calcium; Cardiac Pacing, Artificial; Cell Line; Cell Survival; Cytoprotection; Dose-Response Relationship, Drug; Ethylamines; Mice; Myocytes, Cardiac; Peroxynitrous Acid; Pyridines; Reactive Nitrogen Species; Signal Transduction; Tyrosine | 2015 |
NADPH Oxidase-Derived Peroxynitrite Drives Inflammation in Mice and Human Nonalcoholic Steatohepatitis via TLR4-Lipid Raft Recruitment.
Topics: Animals; Boronic Acids; Humans; Inflammation; Liver; Male; Membrane Microdomains; Mice; Mice, Inbred C57BL; Mice, Obese; Mice, Transgenic; NADPH Oxidases; NF-kappa B; Non-alcoholic Fatty Liver Disease; Peroxynitrous Acid; Signal Transduction; Specific Pathogen-Free Organisms; Toll-Like Receptor 4; Tyrosine | 2015 |
Protein tyrosine phosphatase 1B inhibitory activity of alkaloids from Rhizoma Coptidis and their molecular docking studies.
Topics: Alkaloids; Coptis; Hypoglycemic Agents; Molecular Docking Simulation; Peroxynitrous Acid; Plant Extracts; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Rhizome; Tyrosine | 2015 |
Peroxynitrite and fibrinolytic system-The effects of peroxynitrite on t-PA-induced plasmin activity.
Topics: Amino Acid Sequence; Enzyme Activation; Fibrinolysin; Fibrinolysis; Humans; Models, Molecular; Molecular Sequence Data; Oxidative Stress; Peroxynitrous Acid; Plasminogen; Protein Binding; Protein Conformation; Sequence Alignment; Tissue Plasminogen Activator; Tyrosine | 2015 |
Antioxidant action of six Trifolium species in blood platelet experimental system in vitro.
Topics: Antioxidants; Blood Platelets; Dose-Response Relationship, Drug; Humans; Lipid Peroxides; Oxidative Stress; Peroxynitrous Acid; Phenols; Phytotherapy; Plant Components, Aerial; Plant Extracts; Plants, Medicinal; Thiobarbituric Acid Reactive Substances; Trifolium; Tyrosine | 2015 |
Role of peroxynitrite induced structural changes on H2B histone by physicochemical method.
Topics: Chromatography, High Pressure Liquid; Histones; Hydrophobic and Hydrophilic Interactions; Peroxynitrous Acid; Protein Binding; Protein Conformation; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis; Tyrosine | 2016 |
Intermittent Hypoxia-Induced Carotid Body Chemosensory Potentiation and Hypertension Are Critically Dependent on Peroxynitrite Formation.
Topics: Animals; Azoles; Blood Pressure; Carotid Body; Diastole; Hypertension; Hypoxia; Isoindoles; Male; Neuronal Plasticity; Organoselenium Compounds; Peroxynitrous Acid; Rats, Sprague-Dawley; Systole; Tyrosine | 2016 |
Novel Roles for Peroxynitrite in Angiotensin II and CaMKII Signaling.
Topics: Angiotensin II; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Line; Methionine; Myocytes, Cardiac; Neurons; Oxidation-Reduction; Peroxynitrous Acid; Phosphorylation; Rats; Reactive Oxygen Species; Signal Transduction; Tyrosine | 2016 |
Oxidative Stress in the Developing Rat Brain due to Production of Reactive Oxygen and Nitrogen Species.
Topics: Age Factors; Animals; Animals, Newborn; Brain; Glycosylation; Hydrogen Peroxide; Lipid Peroxidation; Lysine; Microscopy, Fluorescence; Oxidative Stress; Peroxynitrous Acid; Protein Processing, Post-Translational; Rats, Wistar; Reactive Nitrogen Species; Reactive Oxygen Species; Superoxides; Tyrosine | 2016 |
Hearing impairment, cochlear morphology, and peroxynitrite (ONOO(-)) formation in adult and aging NOS II knockout mice.
Topics: Aging; Animals; Cochlea; Female; Hearing Loss; Immunohistochemistry; Mice, Knockout; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Tyrosine | 2016 |
Peroxynitrite-induced structural perturbations in human IgG: A physicochemical study.
Topics: Arthritis, Rheumatoid; Calorimetry, Differential Scanning; Circular Dichroism; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Humans; Immunoglobulin G; Inflammation; Light; Microscopy, Fluorescence; Oxygen; Peroxynitrous Acid; Protein Structure, Secondary; Scattering, Radiation; Sepharose; Spectrophotometry; Spectroscopy, Fourier Transform Infrared; Temperature; Tryptophan; Tyrosine | 2016 |
Mechanism of the Reaction of Human Manganese Superoxide Dismutase with Peroxynitrite: Nitration of Critical Tyrosine 34.
Topics: Blotting, Western; Catalytic Domain; Humans; Kinetics; Models, Molecular; Nitrates; Nitric Oxide; Oxidation-Reduction; Peroxynitrous Acid; Proteomics; Superoxide Dismutase; Tyrosine; Umbelliferones | 2016 |
[Effect of Resveratrol Preconditioning on Myocardial Dysfunction after Cardiac Arrest in Rats].
Topics: Animals; Disease Models, Animal; Heart; Heart Arrest; Ischemic Preconditioning; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Resveratrol; Stilbenes; Tyrosine | 2016 |
The susceptibility of plasma coagulation factor XI to nitration and peroxynitrite action.
Topics: Amino Acid Sequence; Animals; Blotting, Western; Conserved Sequence; Electrophoresis, Polyacrylamide Gel; Evolution, Molecular; Factor XI; Fluorescent Dyes; Humans; Immunoblotting; Immunoprecipitation; Ligands; Molecular Docking Simulation; Nitrosation; Partial Thromboplastin Time; Peroxynitrous Acid; Plasma; Sequence Alignment; Substrate Specificity; Thrombin; Tyrosine | 2016 |
BACE1 molecular docking and anti-Alzheimer's disease activities of ginsenosides.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Binding Sites; Butyrylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Ginsenosides; Molecular Docking Simulation; Oxidative Stress; Peroxynitrous Acid; Protease Inhibitors; Protein Binding; Protein Conformation; Structure-Activity Relationship; Tyrosine | 2016 |
Age-dependent changes in the glutamate-nitric oxide pathway in the hippocampus of the triple transgenic model of Alzheimer's disease: implications for neurometabolic regulation.
Topics: Aging; Alzheimer Disease; Animals; Disease Models, Animal; Energy Metabolism; Glutamic Acid; Hippocampus; Mice, Transgenic; Microelectrodes; Mitochondria; Neurotransmitter Agents; Nitric Oxide; Oxidative Phosphorylation; Oxygen Consumption; Peroxynitrous Acid; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Tyrosine | 2016 |
Targeting nitrative stress for attenuating cisplatin-induced downregulation of cochlear LIM domain only 4 and ototoxicity.
Topics: Adaptor Proteins, Signal Transducing; Animals; Antineoplastic Agents; Apoptosis; Cells, Cultured; Cisplatin; Cochlea; Disease Models, Animal; Down-Regulation; Evoked Potentials, Auditory, Brain Stem; Hearing Loss; LIM Domain Proteins; Manganese Compounds; Membrane Proteins; Mice; Mice, Inbred CBA; Peroxynitrous Acid; Serpins; Signal Transduction; Tyrosine | 2016 |
Activation of mTOR/IκB-α/NF-κB pathway contributes to LPS-induced hypotension and inflammation in rats.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arterial Pressure; Cyclooxygenase 2; Epoprostenol; Gene Expression Regulation, Enzymologic; Heart Rate; Hypotension; I-kappa B Proteins; Inflammation; Lipopolysaccharides; Male; Nitric Oxide; Nitric Oxide Synthase Type II; Peroxidase; Peroxynitrous Acid; Rats; Rats, Wistar; Ribosomal Protein S6; Signal Transduction; TOR Serine-Threonine Kinases; Transcription Factor RelA; Tumor Necrosis Factor-alpha; Tyrosine | 2017 |
Nitration of Tyrosine Residue Y10 of Aβ
Topics: Amyloid beta-Peptides; Cell Line, Tumor; Cell Survival; Circular Dichroism; Humans; Hydrogen Peroxide; Microscopy, Atomic Force; Microscopy, Electron, Transmission; Nitrites; Oxidation-Reduction; Peptide Fragments; Peroxynitrous Acid; Protein Aggregates; Spectrometry, Fluorescence; Tyrosine | 2017 |
Low-Dose Endotoxin Induces Late Preconditioning, Increases Peroxynitrite Formation, and Activates STAT3 in the Rat Heart.
Topics: Animals; Endotoxins; Ischemic Preconditioning, Myocardial; Lactate Dehydrogenases; Lipopolysaccharides; Male; Myocardial Ischemia; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Peroxynitrous Acid; Rats; STAT3 Transcription Factor; Tyrosine | 2017 |
CCL2 nitration is a negative regulator of chemokine-mediated inflammation.
Topics: Animals; Binding Sites; Cell Movement; Chemokine CCL2; Chemokines; Inflammation; Leukocytes; Mice; Monocytes; Oxidative Stress; Peroxynitrous Acid; Reactive Nitrogen Species; Receptors, CCR2; Tyrosine | 2017 |
Tyrosine oxidation and nitration in transmembrane peptides is connected to lipid peroxidation.
Topics: Amidines; Amino Acid Sequence; Cell Membrane; Free Radicals; Hemin; Lipid Peroxidation; Liposomes; Molecular Dynamics Simulation; Oxidation-Reduction; Oxygen; Peptides; Peroxynitrous Acid; Tyrosine | 2017 |
Triosephosphate isomerase tyrosine nitration induced by heme-NaNO
Topics: Acetophenones; Anthracenes; Antioxidants; Circular Dichroism; Flavonoids; Heme; Hydrogen Peroxide; Indicators and Reagents; Kinetics; Molsidomine; Oxidants; Oxidation-Reduction; Peroxynitrous Acid; Phytochemicals; Protein Processing, Post-Translational; Protein Structure, Secondary; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sodium Nitrite; Triose-Phosphate Isomerase; Tyrosine | 2017 |
Peptide-Functionalized Fluorescent Particles for In Situ Detection of Nitric Oxide via Peroxynitrite-Mediated Nitration.
Topics: Biosensing Techniques; Fluorescent Dyes; Human Umbilical Vein Endothelial Cells; Humans; Limit of Detection; Nitric Oxide; Peptides; Peroxynitrous Acid; Tyrosine | 2017 |
Peroxynitrite Footprint in Circulating Neutrophils of Abdominal Aortic Aneurysm Patients is Lower in Statin than in Non-statin Users.
Topics: Adult; Aged; Aged, 80 and over; Aortic Aneurysm, Abdominal; Biomarkers; Case-Control Studies; Female; Humans; Hydrogen Peroxide; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lymphocytes; Male; Middle Aged; Monocytes; Neutrophils; Peroxynitrous Acid; Tyrosine | 2017 |
Nitration of H2B histone elicits an immune response in experimental animals.
Topics: Animals; Autoantibodies; Autoantigens; Autoimmunity; Cross Reactions; Histones; Humans; Immunoglobulin G; Lupus Erythematosus, Systemic; Peroxynitrous Acid; Protein Binding; Rabbits; Tyrosine | 2017 |
Peroxynitrite-Induced Tyrosine Nitration Contributes to Matrix Metalloprotease-3 Activation: Relevance to Hyperglycemic Ischemic Brain Injury and Tissue Plasminogen Activator.
Topics: Animals; Brain; Brain Ischemia; Cerebral Hemorrhage; Disease Models, Animal; Male; Matrix Metalloproteinase 3; Peroxynitrous Acid; Rats, Wistar; Reperfusion Injury; Tissue Plasminogen Activator; Tyrosine | 2018 |
Exposure of tropoelastin to peroxynitrous acid gives high yields of nitrated tyrosine residues, di-tyrosine cross-links and altered protein structure and function.
Topics: Arteries; Atherosclerosis; Cadaver; Elastin; Extracellular Matrix; Humans; Immunohistochemistry; Inflammation; Macrophages; Nitro Compounds; Oxidation-Reduction; Peroxynitrous Acid; Protein Conformation; Tropoelastin; Tyrosine; Unfolded Protein Response | 2018 |
Phenelzine reduces the oxidative damage induced by peroxynitrite in plasma lipids and proteins.
Topics: Adult; Antioxidants; Blood Platelets; Blood Proteins; Free Radical Scavengers; Humans; Lipid Peroxidation; Osmolar Concentration; Oxidation-Reduction; Oxidative Stress; Peroxynitrous Acid; Phenelzine; Plasma; Protein Carbonylation; Thiobarbituric Acid Reactive Substances; Tyrosine; Young Adult | 2018 |
Designing antioxidant peptides based on the antioxidant properties of the amino acid side-chains.
Topics: Amino Acids; Antioxidants; Hydrophobic and Hydrophilic Interactions; Myoglobin; Peptides; Peroxides; Peroxynitrous Acid; Protein Engineering; Reactive Nitrogen Species; Reactive Oxygen Species; Structure-Activity Relationship; Tryptophan; Tyrosine | 2018 |
Proteomic analysis of peroxynitrite-induced protein nitration in isolated beef heart mitochondria.
Topics: Animals; Cattle; In Vitro Techniques; Mitochondria, Heart; Mitochondrial Proteins; Nitrogen; Peroxynitrous Acid; Proteomics; Tyrosine | 2018 |
Protective potential of thymoquinone against peroxynitrite induced modifications in histone H2A: In vitro studies.
Topics: Antioxidants; Arginine; Benzoquinones; Histones; Humans; Lysine; Nigella sativa; Oxidative Stress; Peroxynitrous Acid; Proline; Threonine; Tyrosine | 2018 |
DNA Methylation-a Potential Source of Mitochondria DNA Base Mismatch in the Development of Diabetic Retinopathy.
Topics: Animals; APOBEC Deaminases; Base Pair Mismatch; Base Sequence; Cytosine; Diabetic Retinopathy; DNA Methylation; DNA, Mitochondrial; Endothelial Cells; Humans; Mice, Inbred C57BL; Nucleic Acid Conformation; Peroxynitrous Acid; Superoxide Dismutase; Tyrosine | 2019 |
Inducible nitric oxide synthase-mediated injury in a mouse model of acute salivary gland dysfunction.
Topics: Acinar Cells; Animals; Calcium; Calcium Signaling; Enzyme Inhibitors; Female; Guanidines; Immunity, Innate; Mice, Inbred C57BL; Nitric Oxide Synthase Type II; Nitrosative Stress; Peroxynitrous Acid; Poly I-C; Saliva; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Submandibular Gland; Submandibular Gland Diseases; Tyrosine; Up-Regulation | 2018 |
Branched-chain amino acids promote endothelial dysfunction through increased reactive oxygen species generation and inflammation.
Topics: Amino Acids, Branched-Chain; Animals; Antioxidants; Aorta; E-Selectin; Endothelial Cells; Glucose; Humans; Inflammation; Intercellular Adhesion Molecule-1; Mechanistic Target of Rapamycin Complex 1; Mice; Mitochondria; NF-kappa B; Oxidative Stress; Peroxynitrous Acid; Reactive Oxygen Species; Signal Transduction; Tyrosine; Vasoconstrictor Agents | 2018 |
[Research on the Reaction Dynamics between Peroxynitrite and Tyrosine Catalyzed with Mimic Enzyme through Flow Injection Analyzer].
Topics: Catalysis; Free Radicals; Hydrogen-Ion Concentration; Kinetics; Nitrates; Oxidation-Reduction; Peroxynitrous Acid; Tyrosine | 2016 |
Blocking Tyr265 nitration of protein phosphatase 2A attenuates nitrosative stress-induced endothelial dysfunction in renal microvessels.
Topics: Animals; Cell Line; Endothelial Cells; Endothelium; Human Umbilical Vein Endothelial Cells; Humans; Kidney; Male; Mice; Mice, Inbred C57BL; Microvessels; Nitrosative Stress; Peroxynitrous Acid; Protein Phosphatase 2; Reactive Nitrogen Species; Superoxides; Transforming Growth Factor beta1; Tyrosine; Vascular Diseases | 2019 |
Tyrosine nitrations impaired intracellular trafficking of FSHR to the cell surface and FSH-induced Akt-FoxO3a signaling in human granulosa cells.
Topics: Adult; Cell Line; Female; Follicle Stimulating Hormone; Forkhead Box Protein O3; Granulosa Cells; Humans; Mutagenesis, Site-Directed; Oxidative Stress; Peroxynitrous Acid; Proto-Oncogene Proteins c-akt; Receptors, FSH; Tyrosine | 2019 |
Design of a Protein Motif Responsive to Tyrosine Nitration and an Encoded Turn-Off Sensor of Tyrosine Nitration.
Topics: Amino Acid Motifs; Amino Acid Sequence; Escherichia coli; Luminescence; Maltose-Binding Proteins; Peptides; Peroxynitrous Acid; Proof of Concept Study; Protein Binding; Protein Engineering; Protein Processing, Post-Translational; Recombinant Fusion Proteins; Terbium; Tyrosine | 2019 |
pH-Dependent Nitrotyrosine Formation in Ribonuclease A is Enhanced in the Presence of Polyethylene Glycol (PEG).
Topics: Animals; Cattle; Hydrogen-Ion Concentration; Kinetics; Molecular Docking Simulation; Peroxynitrous Acid; Polyethylene Glycols; Ribonuclease, Pancreatic; Tyrosine | 2019 |
Peroxynitrite is a novel risk factor and treatment target of glaucoma.
Topics: Adult; Aged; Animals; Case-Control Studies; Caveolin 1; Female; Glaucoma, Angle-Closure; Glaucoma, Open-Angle; Humans; Male; Metalloporphyrins; Mice, Knockout; Middle Aged; Peroxynitrous Acid; Risk Factors; Tyrosine | 2020 |
Peroxynitrite-Mediated Structural Changes in Histone H2A: Biochemical and Biophysical Analysis.
Topics: Animals; Histones; Humans; Peroxynitrous Acid; Protein Domains; Protein Folding; Protein Structure, Secondary; Tyrosine | 2020 |
NADPH oxidase subunit NOXO1 is a target for emphysema treatment in COPD.
Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Emphysema; Humans; Hypertension, Pulmonary; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide; Peroxynitrous Acid; Pulmonary Disease, Chronic Obstructive; Signal Transduction; Superoxides; Tobacco Smoke Pollution; Tyrosine | 2020 |
Genetically encoding thyronine for fluorescent detection of peroxynitrite.
Topics: Escherichia coli; Fluorescent Dyes; Green Fluorescent Proteins; HEK293 Cells; HeLa Cells; Humans; Hydrogen Peroxide; Kinetics; Limit of Detection; Oxidation-Reduction; Peroxynitrous Acid; RNA, Transfer; Thyronines; Tyrosine | 2020 |
The Impact of Hypertension and Metabolic Syndrome on Nitrosative Stress and Glutathione Metabolism in Patients with Morbid Obesity.
Topics: Adult; Area Under Curve; Female; Glutathione; Glutathione Disulfide; Humans; Hypertension; Metabolic Syndrome; Middle Aged; Nitric Oxide; Nitrosative Stress; Obesity, Morbid; Oxidation-Reduction; Peroxidase; Peroxynitrous Acid; ROC Curve; Sulfhydryl Compounds; Tyrosine | 2020 |
On the Liquid Chemistry of the Reactive Nitrogen Species Peroxynitrite and Nitrogen Dioxide Generated by Physical Plasmas.
Topics: Diabetes Complications; Humans; Hydrogen Peroxide; Nitrogen; Nitrogen Dioxide; Nitrosative Stress; Oxidation-Reduction; Peroxynitrous Acid; Protein Processing, Post-Translational; Reactive Nitrogen Species; Reactive Oxygen Species; Signal Transduction; Tyrosine; Wound Healing; Wounds and Injuries | 2020 |
Cardiolipin interactions with cytochrome c increase tyrosine nitration yields and site-specificity.
Topics: Animals; Binding Sites; Cardiolipins; Cytochromes c; Horses; Kinetics; Models, Molecular; Nitrates; Peroxynitrous Acid; Protein Conformation; Protein Processing, Post-Translational; Substrate Specificity; Tyrosine | 2021 |
Sustained IKKβ phosphorylation and NF-κB activation by superoxide-induced peroxynitrite-mediated nitrotyrosine modification of B56γ3 and PP2A inactivation.
Topics: I-kappa B Kinase; NF-kappa B; NF-KappaB Inhibitor alpha; Peroxynitrous Acid; Phosphorylation; Protein Phosphatase 2; Superoxides; Tyrosine | 2021 |
A Method for Analysis of Nitrotyrosine-Containing Proteins by Immunoblotting Coupled with Mass Spectrometry.
Topics: Animals; Cattle; Electrophoresis, Gel, Two-Dimensional; Immunoblotting; Mass Spectrometry; Mitochondria, Heart; Mitochondrial Proteins; Peroxynitrous Acid; Tyrosine | 2021 |
Protective Effect of Dinitrosyl Iron Complexes Bound with Hemoglobin on Oxidative Modification by Peroxynitrite.
Topics: Animals; Cattle; Electron Spin Resonance Spectroscopy; Humans; Iron; Methemoglobin; Nitrogen Oxides; Oxidation-Reduction; Peroxynitrous Acid; Tryptophan; Tyrosine | 2021 |
SIRT2 tyrosine nitration by peroxynitrite in response to renal ischemia/reperfusion injury.
Topics: Acute Kidney Injury; Animals; Humans; Ischemia; Kidney; Peroxynitrous Acid; Rats; Reperfusion Injury; Sirtuin 2; Tyrosine | 2021 |
Pheomelanin Effect on UVB Radiation-Induced Oxidation/Nitration of l-Tyrosine.
Topics: Iron; Melanins; Nitrites; Nitrosation; Oxidation-Reduction; Peroxynitrous Acid; Singlet Oxygen; Tyrosine; Ultraviolet Rays | 2021 |
Endothelial cell-derived tetrahydrobiopterin prevents aortic valve calcification.
Topics: Animals; Aortic Valve; Aortic Valve Stenosis; Apolipoproteins E; Biopterins; Calcinosis; Cells, Cultured; Core Binding Factor Alpha 1 Subunit; Endothelial Cells; GTP Cyclohydrolase; Humans; Mice; Peroxynitrous Acid; Tyrosine | 2022 |
A Fluorescent Cage for Supramolecular Sensing of 3-Nitrotyrosine in Human Blood Serum.
Topics: Humans; Peroxynitrous Acid; Reactive Nitrogen Species; Serum; Tyrosine | 2022 |
Dynamics of nitration during dark-induced leaf senescence in Arabidopsis reveals proteins modified by tryptophan nitration.
Topics: Arabidopsis; Nitric Oxide; Peroxynitrous Acid; Plant Senescence; Plants; RNA; Tryptophan; Tyrosine | 2022 |
Alpha-Ketoglutarate or 5-HMF: Single Compounds Effectively Eliminate Leukemia Cells via Caspase-3 Apoptosis and Antioxidative Pathways.
Topics: Antioxidants; Apoptosis; Caspase 3; Caspases; Humans; Jurkat Cells; Ketoglutaric Acids; Leukemia; Peroxynitrous Acid; Tyrosine | 2022 |
Impact of Protein Nitration on Influenza Virus Infectivity and Immunogenicity.
Topics: Animals; Anti-Infective Agents; Communicable Diseases; Hemagglutinins; Humans; Influenza, Human; Mice; Nitric Oxide; Orthomyxoviridae; Peroxynitrous Acid; Tyrosine; Virus Diseases | 2022 |
Probing Tyrosine Nitration with a Small Tb
Topics: Peroxynitrous Acid; Proteins; Tyrosine | 2023 |
2-Oxo-imidazole dipeptides inhibit peroxynitrite-dependent tyrosine nitration.
Topics: Anserine; Carnosine; Dipeptides; Imidazoles; Peroxynitrous Acid; Tyrosine | 2023 |