peroxynitrous acid has been researched along with sapropterin in 30 studies
| Studies (peroxynitrous acid) | Trials (peroxynitrous acid) | Recent Studies (post-2010) (peroxynitrous acid) | Studies (sapropterin) | Trials (sapropterin) | Recent Studies (post-2010) (sapropterin) |
|---|---|---|---|---|---|
| 3,303 | 21 | 1,230 | 2,362 | 93 | 614 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 19 (63.33) | 29.6817 |
| 2010's | 10 (33.33) | 24.3611 |
| 2020's | 1 (3.33) | 2.80 |
| Authors | Studies |
|---|---|
| Cheng, TH; Hong, HJ; Hsiao, G; Yen, MH | 1 |
| Deby, CM; Deby-Dupont, GP; Kohnen, SL; Lamy, ML; Mouithys-Mickalad, AA; Noels, AF | 1 |
| Cohen, RA; Shi, C; Zou, MH | 1 |
| Torreilles, F; Touchon, J | 1 |
| Almeida, A; Delgado-Esteban, M; Medina, JM | 1 |
| Dikalov, S; Harrison, DG; Kuzkaya, N; Weissmann, N | 1 |
| Esberg, LB; Ren, J | 1 |
| Geddes, TJ; Kuhn, DM | 1 |
| Geddes, TJ; Kuhn, DM; Sadidi, M; Sakowski, SA | 1 |
| Akamine, EH; Carvalho, MH; de Britto, LR; Fortes, ZB; Franco, Mdo C; Kawamoto, EM; Muscara, MN; Nigro, D; Scavone, C; Teixeira, SA; Tostes, RC | 1 |
| Hagiwara, T; Ishii, M; Kiuchi, Y; Miyasaka, Y; Negoro, T; Shimizu, S; Wajima, T | 1 |
| Chen, AF; Hong, H; Kaufman, DI; Kidd, GA; Majid, A | 1 |
| Chae, HJ; Chae, SW; Cheung, GS; Chung, HT; Ha, KC; Kim, DS; Kim, HM; Kim, HR; Kim, YM; Kwak, YG; Pae, HO | 1 |
| Brandacher, G; Hengster, P; Hermann, M; Maglione, M; Margreiter, R; Mark, W; Obrist, P; Schneeberger, S; Werner, ER; Werner-Felmayer, G | 1 |
| Antoniades, C; Cai, S; Channon, KM; de Bono, J; Lee, J; Leeson, P; Neubauer, S; Pillai, R; Ratnatunga, C; Refsum, H; Shirodaria, C; Warrick, N | 1 |
| Song, P; Wang, S; Wu, Y; Xu, J; Zhang, M; Zou, MH | 1 |
| McCarty, MF | 1 |
| Daiber, A; Jansen, T; Münzel, T; Schulz, E; Wenzel, P | 1 |
| Song, P; Wang, S; Wu, Y; Xu, J; Zou, MH | 1 |
| Davidge, ST; Sankaralingam, S; Xu, H | 1 |
| Berka, V; Chen, CA; Chen, W; Chen, YR; Druhan, LJ; Hemann, C; Tsai, AL; Zweier, JL | 1 |
| Brandacher, G; Cardini, B; Hengster, P; Hermann, M; Maglione, M; Margreiter, R; Mark, W; Oberhuber, R; Obrist, P; Pratschke, J; Schneeberger, S; Watschinger, K; Werner, ER; Werner-Felmayer, G | 1 |
| Song, P; Xu, J; Zhang, M; Zou, MH | 1 |
| Berbee, M; Boerma, M; Fu, Q; Hauer-Jensen, M; Kumar, KS; Pathak, R; Zhou, D | 1 |
| Kar, S; Kavdia, M | 1 |
| Chen, J; Tan, Z; Wang, J; Zhu, M | 1 |
| Gorren, AC; Kolesnik, B; Mayer, B; Neubauer, A; Schmidt, K; Stasch, JP; Werner, ER | 1 |
| Aykin-Burns, N; Berbée, M; Biju, PG; Boerma, M; Cheema, AK; Fu, Q; Garg, S; Ghosh, SP; Gupta, PK; Hauer-Jensen, M; Hendrickson, HP; Krager, KJ; Pathak, R; Pawar, SA; Sridharan, V; Wang, W | 1 |
| Alam, A; Cardnell, RJ; Graves, P; Mikkelsen, RB; Mukhopadhyay, ND; Rabender, CS; Sundaresan, G; Yakovlev, VA; Zweit, J | 1 |
| Cai, Z; Dong, N; Feng, J; Hui, H; Li, F; Liu, F; Liu, M; Liu, Z; Rao, Z; Shang, Y; Wang, Y; Xu, L; Yuan, Z | 1 |
3 review(s) available for peroxynitrous acid and sapropterin
| Article | Year |
|---|---|
Pathogenic theories and intrathecal analysis of the sporadic form of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Arginine; Biopterins; Brain; Brain Chemistry; Calcium; Cerebrospinal Fluid; Cerebrospinal Fluid Proteins; Humans; Inflammation; Isoenzymes; Models, Biological; Nerve Degeneration; Nerve Growth Factors; Nerve Tissue Proteins; Neurofibrillary Tangles; Nitric Oxide Synthase; Oxidative Stress; Peroxynitrous Acid; Phosphorylation; Protein Processing, Post-Translational; Synaptic Transmission; tau Proteins | 2002 |
Nitrotyrosine as a marker for peroxynitrite-induced neurotoxicity: the beginning or the end of the end of dopamine neurons?
Topics: Animals; Biomarkers; Biopterins; Dopamine; Humans; Neurons; Peroxynitrous Acid; Quinones; Tyrosine | 2004 |
Nitric oxide, tetrahydrobiopterin, oxidative stress, and endothelial dysfunction in hypertension.
Topics: Animals; Biopterins; Cyclic GMP-Dependent Protein Kinases; Endothelium, Vascular; Guanylate Cyclase; Humans; Hypertension; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Peroxynitrous Acid; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase | 2008 |
1 trial(s) available for peroxynitrous acid and sapropterin
| Article | Year |
|---|---|
5-methyltetrahydrofolate rapidly improves endothelial function and decreases superoxide production in human vessels: effects on vascular tetrahydrobiopterin availability and endothelial nitric oxide synthase coupling.
Topics: Acetylcholine; Antioxidants; Atherosclerosis; Biological Availability; Biopterins; Bradykinin; Coronary Artery Bypass; Coronary Artery Disease; Double-Blind Method; Endothelium, Vascular; Homocysteine; Humans; Nitric Oxide; Nitric Oxide Synthase Type III; Peroxynitrous Acid; Protein Binding; Superoxides; Tetrahydrofolates | 2006 |
26 other study(ies) available for peroxynitrous acid and sapropterin
| Article | Year |
|---|---|
Supplemention with tetrahydrobiopterin suppresses the development of hypertension in spontaneously hypertensive rats.
Topics: Acetylcholine; Animals; Antioxidants; Aorta; Biopterins; Blood Pressure; Culture Techniques; Dietary Supplements; Endothelium, Vascular; Hypertension; Male; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Superoxides; Vasodilation | 2001 |
Oxidation of tetrahydrobiopterin by peroxynitrite or oxoferryl species occurs by a radical pathway.
Topics: Biopterins; Chlorine; Electron Spin Resonance Spectroscopy; Free Radicals; Oxidation-Reduction; Oxides; Peroxynitrous Acid; Signal Transduction; Spectrophotometry, Ultraviolet; Time Factors | 2001 |
Oxidation of the zinc-thiolate complex and uncoupling of endothelial nitric oxide synthase by peroxynitrite.
Topics: Animals; Antioxidants; Biopterins; Cattle; Cell Line; Detergents; Diabetes Mellitus, Experimental; Dimerization; Endothelium, Vascular; Glucose; Male; Mice; Mice, Inbred NOD; Mice, Knockout; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidants; Oxidation-Reduction; Peroxynitrous Acid; Receptors, LDL; Recombinant Proteins; Sodium Dodecyl Sulfate; Zinc | 2002 |
Tetrahydrobiopterin deficiency increases neuronal vulnerability to hypoxia.
Topics: Adenosine Triphosphate; Animals; Antioxidants; Biopterins; Cell Death; Cell Hypoxia; Cells, Cultured; Cyclic GMP; Enzyme Inhibitors; GTP Cyclohydrolase; Hypoxanthines; Hypoxia, Brain; Mitochondria; Neurons; Nitric Oxide Synthase; Oxidative Stress; Peroxynitrous Acid; Rats; Rats, Wistar | 2002 |
Interactions of peroxynitrite, tetrahydrobiopterin, ascorbic acid, and thiols: implications for uncoupling endothelial nitric-oxide synthase.
Topics: Animals; Aorta; Ascorbic Acid; Biopterins; Cattle; Cells, Cultured; Endothelium, Vascular; Kinetics; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Peroxynitrous Acid; Spin Labels; Sulfhydryl Compounds | 2003 |
Role of nitric oxide, tetrahydrobiopterin and peroxynitrite in glucose toxicity-associated contractile dysfunction in ventricular myocytes.
Topics: Animals; Biopterins; Calcium; Cells, Cultured; Enzyme Inhibitors; Free Radical Scavengers; Glucose; Intracellular Membranes; Male; Myocardial Contraction; Myocytes, Cardiac; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Ventricular Dysfunction | 2003 |
Tetrahydrobiopterin prevents nitration of tyrosine hydroxylase by peroxynitrite and nitrogen dioxide.
Topics: Animals; Antioxidants; Biopterins; Cells, Cultured; Humans; Nitrogen Dioxide; Peroxynitrous Acid; Rats; Reactive Nitrogen Species; Tyrosine 3-Monooxygenase | 2003 |
Tetrahydrobiopterin improves endothelial dysfunction and vascular oxidative stress in microvessels of intrauterine undernourished rats.
Topics: Animals; Antioxidants; Biopterins; Blotting, Western; Caloric Restriction; Endothelium, Vascular; Female; Fetal Nutrition Disorders; Male; Microcirculation; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxidative Stress; Peroxynitrous Acid; Pregnancy; Rats; Rats, Wistar; RNA, Messenger; Superoxides; Tyrosine; Uterus; Vasodilation | 2004 |
Possible involvement of hydroxyl radical on the stimulation of tetrahydrobiopterin synthesis by hydrogen peroxide and peroxynitrite in vascular endothelial cells.
Topics: Animals; Biopterins; Cell-Free System; Cells, Cultured; Endothelium, Vascular; Hydrogen Peroxide; Hydroxyl Radical; Mice; Peroxynitrous Acid | 2005 |
Inhibition of brain GTP cyclohydrolase I and tetrahydrobiopterin attenuates cerebral infarction via reducing inducible NO synthase and peroxynitrite in ischemic stroke.
Topics: Animals; Biopterins; Brain; Cerebral Infarction; GTP Cyclohydrolase; Hypoxanthines; Male; Nitric Oxide Synthase; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Superoxides | 2005 |
Catalase protects cardiomyocytes via its inhibition of nitric oxide synthesis.
Topics: Animals; Apoptosis; Biopterins; Catalase; Cytokines; Heart Ventricles; Interferon-Stimulated Gene Factor 3; Interleukin-1; Myocytes, Cardiac; NF-kappa B; Nitric Oxide; Peroxynitrous Acid; Rats; Rats, Wistar; Reactive Oxygen Species; Tumor Necrosis Factor-alpha | 2006 |
Tetrahydrobiopterin attenuates microvascular reperfusion injury following murine pancreas transplantation.
Topics: Animals; Biopterins; Male; Mice; Mice, Inbred C57BL; Microcirculation; Pancreas Transplantation; Peroxynitrous Acid; Reperfusion Injury; Transplantation, Homologous; Tyrosine | 2006 |
Proteasome-dependent degradation of guanosine 5'-triphosphate cyclohydrolase I causes tetrahydrobiopterin deficiency in diabetes mellitus.
Topics: Animals; Antioxidants; Aorta; Biopterins; Cells, Cultured; Cyclic N-Oxides; Cysteine Proteinase Inhibitors; Diabetes Mellitus, Experimental; Endothelial Cells; Glucose; GTP Cyclohydrolase; Guanosine Triphosphate; Leupeptins; Mice; Mice, Inbred C57BL; Nitrogen; Organ Culture Techniques; Peroxynitrous Acid; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Reactive Oxygen Species; Spin Labels; Tyrosine; Ubiquitin; Umbilical Veins | 2007 |
Gamma-tocopherol may promote effective no synthase function by protecting tetrahydrobiopterin from peroxynitrite.
Topics: Animals; Biopterins; Clinical Trials as Topic; Coronary Disease; Diet; Endothelium; gamma-Tocopherol; Humans; Models, Biological; Models, Theoretical; Nuts; Peroxynitrous Acid; Risk | 2007 |
Tyrosine nitration of PA700 activates the 26S proteasome to induce endothelial dysfunction in mice with angiotensin II-induced hypertension.
Topics: Angiotensin II; Animals; Aorta; Biopterins; Blood Pressure; Cells, Cultured; Cysteine Proteinase Inhibitors; Endothelial Cells; Endothelium, Vascular; GTP Cyclohydrolase; Humans; Hypertension; In Vitro Techniques; Leupeptins; Mice; Mice, Inbred C57BL; Nitrates; Peroxynitrous Acid; Proteasome Endopeptidase Complex; Proteasome Inhibitors; RNA, Small Interfering; Transfection; Tyrosine; Vasodilation | 2009 |
Arginase contributes to endothelial cell oxidative stress in response to plasma from women with preeclampsia.
Topics: Arginase; Arginine; Biopterins; Endothelial Cells; Female; Humans; Molsidomine; NADPH Oxidases; NF-kappa B; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxidative Stress; Peroxynitrous Acid; Pre-Eclampsia; Pregnancy | 2010 |
Peroxynitrite induces destruction of the tetrahydrobiopterin and heme in endothelial nitric oxide synthase: transition from reversible to irreversible enzyme inhibition.
Topics: Biopterins; Boranes; Enzyme Stability; Heme; Hemin; Humans; Nitric Oxide Synthase Type III; Peroxynitrous Acid; Protein Binding; Protein Multimerization; Zinc | 2010 |
Donor pretreatment with tetrahydrobiopterin saves pancreatic isografts from ischemia reperfusion injury in a mouse model.
Topics: Animals; Biopterins; Cold Ischemia; Male; Mice; Mice, Inbred C57BL; Microcirculation; Models, Animal; Pancreas; Pancreas Transplantation; Peroxynitrous Acid; Reperfusion Injury; Tissue Donors; Transplantation, Isogeneic; Tyrosine | 2010 |
Activation of NAD(P)H oxidases by thromboxane A2 receptor uncouples endothelial nitric oxide synthase.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Apoptosis; Biopterins; Bridged Bicyclo Compounds, Heterocyclic; Cattle; Cell Survival; Cells, Cultured; Cyclic GMP; Cytochrome P-450 Enzyme System; Endothelial Cells; Enzyme Activation; Enzyme Inhibitors; Fatty Acids, Unsaturated; Intramolecular Oxidoreductases; Mice; Mice, Inbred C57BL; Mice, Knockout; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Peroxynitrous Acid; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Protein Transport; Receptors, Immunologic; Receptors, Thromboxane A2, Prostaglandin H2; RNA Interference; Signal Transduction; Superoxides; Time Factors; Tyrosine | 2011 |
Reduction of radiation-induced vascular nitrosative stress by the vitamin E analog γ-tocotrienol: evidence of a role for tetrahydrobiopterin.
Topics: Animals; Apoptosis; Biological Availability; Biopterins; Bone Marrow Cells; Chromans; Colony-Forming Units Assay; Endothelial Cells; Endothelium, Vascular; GTP Cyclohydrolase; Intracellular Signaling Peptides and Proteins; Lung; Male; Mice; Nitric Oxide Synthase; Oxidative Stress; Peroxynitrous Acid; Protein Binding; Radiation Dosage; Random Allocation; Transcription, Genetic; Vitamin E; Whole-Body Irradiation | 2011 |
Modeling of biopterin-dependent pathways of eNOS for nitric oxide and superoxide production.
Topics: Biocatalysis; Biopterins; Carbon Dioxide; Endothelial Cells; Enzyme Activation; Kinetics; Models, Chemical; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidation-Reduction; Oxidative Stress; Oxygen; Peroxynitrous Acid; Protein Binding; Superoxides | 2011 |
Propofol protects against high glucose-induced endothelial dysfunction in human umbilical vein endothelial cells.
Topics: Anesthetics, Intravenous; Antioxidants; Biopterins; Blotting, Western; Cells, Cultured; Chromatography, Liquid; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Glucose; GTP Cyclohydrolase; Human Umbilical Vein Endothelial Cells; Humans; Hyperglycemia; Mass Spectrometry; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Peroxynitrous Acid; Phosphorylation; Propofol; Protein Multimerization; Superoxides; Time Factors | 2012 |
Tetrahydrobiopterin protects soluble guanylate cyclase against oxidative inactivation.
Topics: Animals; Aorta; Biopterins; Cardiovascular Diseases; Cells, Cultured; Cyclic GMP; Endothelial Cells; Fibroblasts; Guanylate Cyclase; Heme; Nitric Oxide; Nitric Oxide Synthase; Nitroglycerin; Oxidation-Reduction; Oxidative Stress; Peroxynitrous Acid; Pterins; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Superoxides; Swine | 2012 |
Characterization of transgenic Gfrp knock-in mice: implications for tetrahydrobiopterin in modulation of normal tissue radiation responses.
Topics: Animals; Biopterins; Carrier Proteins; Female; Gene Expression; Gene Order; Gene Targeting; Glutathione; Leukocyte Count; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mitochondria; Models, Biological; Oxidative Stress; Peroxynitrous Acid; Protein Binding; Radiation, Ionizing; RNA, Messenger | 2014 |
The Role of Nitric Oxide Synthase Uncoupling in Tumor Progression.
Topics: Animals; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; beta Catenin; Biopterins; Cell Line, Tumor; Cyclic GMP-Dependent Protein Kinases; Disease Progression; Heterografts; Humans; Mice, Nude; Neoplasms; NF-kappa B; Nitric Oxide Synthase; Peroxynitrous Acid; Pterins; Superoxides; Transcription Factor 4; Transcription Factors | 2015 |
Endothelial cell-derived tetrahydrobiopterin prevents aortic valve calcification.
Topics: Animals; Aortic Valve; Aortic Valve Stenosis; Apolipoproteins E; Biopterins; Calcinosis; Cells, Cultured; Core Binding Factor Alpha 1 Subunit; Endothelial Cells; GTP Cyclohydrolase; Humans; Mice; Peroxynitrous Acid; Tyrosine | 2022 |