peroxynitrous acid has been researched along with morphine in 10 studies
| Studies (peroxynitrous acid) | Trials (peroxynitrous acid) | Recent Studies (post-2010) (peroxynitrous acid) | Studies (morphine) | Trials (morphine) | Recent Studies (post-2010) (morphine) |
|---|---|---|---|---|---|
| 3,303 | 21 | 1,230 | 44,270 | 5,200 | 8,695 |
| Protein | Taxonomy | peroxynitrous acid (IC50) | morphine (IC50) |
|---|---|---|---|
| Delta-type opioid receptor | Mus musculus (house mouse) | 0.2939 | |
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | 0.2278 | |
| Kappa-type opioid receptor | Mus musculus (house mouse) | 0.0828 | |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0385 | |
| Kappa-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0545 | |
| Mu-type opioid receptor | Homo sapiens (human) | 0.122 | |
| Delta-type opioid receptor | Homo sapiens (human) | 0.1199 | |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.9308 | |
| Kappa-type opioid receptor | Homo sapiens (human) | 0.655 | |
| Mu-type opioid receptor | Mus musculus (house mouse) | 0.3305 | |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.202 | |
| Beta-2 adrenergic receptor | Cavia porcellus (domestic guinea pig) | 0.25 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (60.00) | 29.6817 |
| 2010's | 4 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Abacioglu, N; Altug, S; Cakici, I; Tunctan, B; Uludag, O; Zengil, H | 1 |
| Pasternak, GW | 1 |
| Batinić-Haberle, I; Cuzzocrea, S; Ndengele, MM; Rebouças, JS; Salvemini, D; Spasojević, I | 1 |
| Salvemini, D | 1 |
| Cuzzocrea, S; Esposito, E; Li, D; Masini, E; Matuschak, GM; Mazzon, E; Mollace, V; Muscoli, C; Ndengele, MM; Petrache, I; Petrusca, DN; Salvemini, D; Vinci, MC | 1 |
| Neumann, W; Salvemini, D | 1 |
| Batinic-Haberle, I; Bryant, L; Cuzzocrea, S; Doyle, T; Little, J; Masini, E; Salvemini, D; Spasojevic, I | 1 |
| Bryant, L; Cuzzocrea, S; Doyle, T; Esposito, E; Salvemini, D | 1 |
| Discala, JF; Gruber, RB; Lewis, SJ; May, WJ; McLaughlin, D; Palmer, LA; Young, AP | 1 |
| Bryant, L; Cuzzocrea, S; Doyle, T; Esposito, E; Little, JW; Neumann, WL; Rausaria, S; Salvemini, D | 1 |
2 review(s) available for peroxynitrous acid and morphine
| Article | Year |
|---|---|
Peroxynitrite and opiate antinociceptive tolerance: a painful reality.
Topics: Analgesics, Opioid; Chronic Disease; Drug Resistance; Drug Tolerance; Glutamates; Homeostasis; Humans; Morphine; Oxidative Stress; Pain; Peroxynitrous Acid | 2009 |
Targeting peroxynitrite driven nitroxidative stress with synzymes: A novel therapeutic approach in chronic pain management.
Topics: Analgesics, Opioid; Animals; Antioxidants; Chronic Disease; Drug Delivery Systems; Drug Tolerance; Enzyme Therapy; Enzymes; Humans; Morphine; Oxidative Stress; Pain; Peroxynitrous Acid | 2010 |
8 other study(ies) available for peroxynitrous acid and morphine
| Article | Year |
|---|---|
Biological time-dependent difference in effect of peroxynitrite demonstrated by the mouse hot plate pain model.
Topics: Analgesics; Animals; Circadian Rhythm; Female; Male; Mice; Models, Biological; Morphine; Nitric Oxide; Nociceptors; Pain; Pain Measurement; Peroxynitrous Acid; Photoperiod | 2006 |
When it comes to opiates, just say NO.
Topics: Analgesics, Opioid; Animals; Drug Tolerance; Mice; Morphine; Nitric Oxide; Peroxynitrous Acid; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Tyrosine | 2007 |
Lipophilicity is a critical parameter that dominates the efficacy of metalloporphyrins in blocking the development of morphine antinociceptive tolerance through peroxynitrite-mediated pathways.
Topics: Analgesics; Animals; Drug Tolerance; Humans; Hydrophobic and Hydrophilic Interactions; Interleukin-1beta; Interleukin-6; Male; Metalloporphyrins; Mice; Morphine; Motor Activity; Oxidative Stress; Pain; Peroxynitrous Acid; Tumor Necrosis Factor-alpha | 2009 |
Spinal ceramide modulates the development of morphine antinociceptive tolerance via peroxynitrite-mediated nitroxidative stress and neuroimmune activation.
Topics: Analgesics, Opioid; Animals; Blotting, Western; Ceramides; Drug Tolerance; Glial Fibrillary Acidic Protein; I-kappa B Proteins; Immunohistochemistry; Male; Mice; Morphine; Neurons; Oxidative Stress; Oxidoreductases; Peroxynitrous Acid; Postural Balance; Serine C-Palmitoyltransferase; Sphingomyelin Phosphodiesterase; Sphingomyelins; Spinal Cord; Superoxide Dismutase | 2009 |
Supraspinal inactivation of mitochondrial superoxide dismutase is a source of peroxynitrite in the development of morphine antinociceptive tolerance.
Topics: Analgesics; Animals; Blood-Brain Barrier; Brain; DNA Damage; Drug Tolerance; Male; Manganese Compounds; Mice; Mice, Inbred Strains; Mitochondria; Morphine; Oxidation-Reduction; Oxidative Stress; Peroxynitrous Acid; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Superoxide Dismutase | 2009 |
NADPH-oxidase 2 activation promotes opioid-induced antinociceptive tolerance in mice.
Topics: Analgesics, Opioid; Animals; Drug Tolerance; Enzyme Activation; Inflammation; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphine; NADPH Oxidase 2; NADPH Oxidases; Pain; Peroxynitrous Acid; Spinal Cord; Superoxide Dismutase | 2013 |
Co-activation of μ- and δ-opioid receptors elicits tolerance to morphine-induced ventilatory depression via generation of peroxynitrite.
Topics: Analysis of Variance; Animals; Antidotes; Drug Tolerance; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Penicillamine; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Respiratory Insufficiency; Time Factors | 2013 |
Spinal mitochondrial-derived peroxynitrite enhances neuroimmune activation during morphine hyperalgesia and antinociceptive tolerance.
Topics: Analgesics; Analgesics, Opioid; Animals; Drug Interactions; Drug Tolerance; Hyperalgesia; Male; Mitochondria; Morphine; Neuroimmunomodulation; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Spinal Cord; Treatment Outcome | 2013 |