Page last updated: 2024-09-03

peroxynitrous acid and mocetinostat

peroxynitrous acid has been researched along with mocetinostat in 77 studies

Compound Research Comparison

Studies
(peroxynitrous acid)
Trials
(peroxynitrous acid)
Recent Studies (post-2010)
(peroxynitrous acid)
Studies
(mocetinostat)
Trials
(mocetinostat)
Recent Studies (post-2010) (mocetinostat)
3,303211,23021,7353908,606

Protein Interaction Comparison

ProteinTaxonomyperoxynitrous acid (IC50)mocetinostat (IC50)
Histone deacetylase 3Homo sapiens (human)0.7851
Nuclear receptor corepressor 1Homo sapiens (human)0.022
Cytochrome P450 3A4Homo sapiens (human)0.57
Cytochrome P450 2D6Homo sapiens (human)0.102
Cytochrome P450 2C19Homo sapiens (human)0.102
Histone deacetylase 4Homo sapiens (human)0.5717
Histone deacetylase 1Homo sapiens (human)0.3433
Histone deacetylase 7Homo sapiens (human)0.6725
Histone deacetylase 2Homo sapiens (human)0.3537
Histone deacetylase 11 Homo sapiens (human)0.6386
Histone deacetylase 8Homo sapiens (human)0.6725
Histone deacetylase 6Homo sapiens (human)0.5717
Histone deacetylase 5Homo sapiens (human)0.6725
Nuclear receptor corepressor 2Homo sapiens (human)0.045

Research

Studies (77)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's53 (68.83)29.6817
2010's22 (28.57)24.3611
2020's2 (2.60)2.80

Authors

AuthorsStudies
Augusto, O; Giorgio, S; Linares, E; Mortara, RA; Santos, CX; Yamada, AT1
Lass, A; Mayer, B; Pfeiffer, S; Schmidt, K1
Caputi, AP; Centorrino, T; Ciccolo, A; Cuzzocrea, S; Dugo, L; Mazzon, E; Sautebin, L; Serraino, I1
Aratani, Y; Fukuyama, N; Hirabayashi, H; Koyama, H; Maeda, N; Nakazawa, H; Shinohara, Y; Takizawa, S1
Espey, MG; Miranda, KM; Thomas, DD; Wink, DA; Xavier, S1
Baloglu, E; Gallyas, F; Haskó, G; Hoyt, DG; Jagtap, P; Liaudet, L; Lorigados, CB; Mabley, J; Marton, A; Salzman, AL; Soriano, FG; Southan, GJ; Sümegi, B; Szabó, C; Szabó, E; VanDuzer, J; Virág, L1
Galiñanes, M; Matata, BM1
Ikeda, M; Suzuki, M; Tabuchi, M; Tomita, T1
Hataishi, R; Hirano, S; Jones, RC; Kobayashi, H; Takahashi, Y; Zapol, WM1
Barbera, A; Caputi, AP; Centorrino, T; Chatterjee, PK; Ciccolo, A; Cuzzocrea, S; Dugo, L; Fulia, F; Mazzon, E; McDonald, MC; Serraino, I; Thiemermann, C1
Persson, K; Poljakovic, M1
Fraga, C; Mulligan, MS; Naidu, BV; Salzman, AL; Szabo, C; Verrier, ED1
Iho, S; Iwasaki, H; Kobayashi, C; Muramatsu, I; Nakamura, K; Nakao, K; Sasaki, Y; Takahashi, T; Takauji, R; Tanaka, Y1
Elstner, EF; Schempp, H; Toth, A; Weiser, D1
André d'Avignon, D; Byun, J; Heinecke, JW; Henderson, JP; Yeh, GC1
Fukushi, Y; Ichiba, T; Sakihama, Y; Shimoji, H; Tahara, S; Tamaki, R; Yamasaki, H1
Andrekopoulos, C; Joseph, J; Kalivendi, S; Kalyanaraman, B; Zhang, H1
Herold, S1
Dedon, PC; Tannenbaum, SR1
Autore, G; Britti, D; Cuzzocrea, S; Di Paola, R; Genovese, T; Marzocco, S; Pinto, A; Scollo, G; Sorrentino, R1
Deretic, V; Master, S; Rusnak, F; Timmins, GS1
Bergt, C; Brunzell, J; Byun, J; Chait, A; Geary, RL; Green, PS; Heinecke, JW; Kassim, SY; McDonald, TO; O'brien, K; Oram, JF; Pennathur, S; Shao, B; Singh, P1
Cinel, I; Cinel, L; Ercan, B; Kanik, A; Koksel, O; Oral, U; Ozdulger, A; Tamer, L1
Chang, WJ; Chen, JS; Chen, LW; Hsu, CM; Hwang, B; Wang, JS1
Bergt, C; Fu, X; Green, P; Heinecke, JW; Oda, MN; Oram, JF; Shao, B; Voss, JC1
Cuzzocrea, S; Genovese, T; Hooper, DC; Koprowski, H; Scott, GS1
Brandes, RP; Brandt, U; Dröse, S; Fleming, I; Keller, A; Mohamed, A1
Aoyagi, K; Cho, EJ; Rhyu, DY; Shibahara, N; Yokozawa, T1
Chen, M; Henderson, JD; Johnson, CP; Khanna, AK; Nilakantan, V; Pieper, GM; Roza, AM; Szabó, C; Zhou, J1
Batthyány, C; Cassina, A; Cerveñansky, C; Durán, R; Radi, R; Souza, JM1
Aksöyek, S; Avlan, D; Camdeviren, H; Ozturhan, H; Oztürk, C; Tamer, L; Taşkinlar, H1
Fujimura, T; Ikeda, K; Imai, T; Matsumoto, T; Murayama, K; Taka, H; Takamori, K; Tamaki, M; Watanabe, E; Yamakura, F1
Furtmüller, PG; Herold, S; Jakopitsch, C; Jantschko, W; Koppenol, WH; Obinger, C; Schwanninger, M; Zederbauer, M1
Chang, WJ; Chen, LW; Hsu, CM; Wang, JS2
Akgoz, M; Cigremis, Y; Erdogan, K; Gaffaroglu, M; Kart, A; Ozen, H; Ozugurlu, F; Turkoz, Y; Tuzcu, M1
Fontana, M; Montefoschi, G; Pecci, L; Rosei, MA; Schininá, ME1
Armstrong, MU; Gookin, JL; Jones, SL; Stauffer, SH; Zadrozny, LM1
Pimental, D; Reece, R; Xie, Z; Xu, J; Zou, MH1
Bezerra, MM; Brain, SD; Girão, VC; Greenacre, S; Keeble, J; Rocha, FA1
Ayan, E; Ayaz, L; Bayram Kaplan, M; Karabacak, T; Koksel, O; Ozdulger, A; Tamer, L1
Eaton, S; Klein, NJ; Pierro, A; Smith, VV; Stefanutti, G1
Bramanti, P; Cuzzocrea, S; Di Paola, R; Esposito, E; Genovese, T; Mazzon, E; Muià, C1
Spencer, JP; Whiteman, M1
Forlenza, M; Kachamakova, NM; Rombout, JH; Scharsack, JP; Taverne-Thiele, AJ; Wiegertjes, GF1
Dohare, P; Garg, P; Jain, V; Nath, C; Ray, M1
Belmadani, S; Elford, H; Gao, X; Potter, BJ; Wu, J; Xu, X; Zhang, C; Zhang, H1
Enkhbaatar, P; Herndon, DN; Maybauer, DM; Maybauer, MO; Murthy, KG; Nakano, Y; Salzman, AL; Szabó, C; Traber, DL; Traber, LD; Westphal, M1
Joseph, J; Kalyanaraman, B; Sikora, A; Xu, Y; Zhang, H; Zielonka, J1
Augusto, O; Di Mascio, P; Prado, FM; Vaz, SM1
Bramanti, P; Cuzzocrea, S; Di Paola, R; Esposito, E; Genovese, T; Mazzon, E; Murthy, K; Neville, L1
Abdulhamid, I; Abu-Soud, HM; Galijasevic, S; Lu, T; Maitra, D; Sliskovic, I1
Barros, MP; Bechara, EJ; Dyszy, FH; Faria, PA; Mano, CM; Nantes, IL; Nascimento, OR; Prieto, T1
Hurst, JK; Seth, N; Suquet, C; Warren, JJ1
Cox, RA; Hawkins, HK; Herndon, DN; Horvath, EM; Kiss, L; Maybauer, DM; Maybauer, MO; Salzman, AL; Southan, GJ; Szabó, C; Traber, DL; Traber, LD; Westphal, M1
Connelly, R; Cox, RA; Enkhbaatar, P; Esechie, A; Hamahata, A; Herndon, DN; Horvath, E; Lange, M; Nakano, Y; Szabo, C; Traber, DL; Traber, LD1
Lorigados, CB; Pacher, P; Soriano, FG; Szabó, C1
Edmé, JL; Hulo, S; Lancel, S; Nevière, R; Sobaszek, A; Tiesset, H; Viollet, B1
Bhabak, KP; Jayavelu, S; Mugesh, G; Satheeshkumar, K1
Ferrari, CK; França, EL; Honorio-França, AC; Souto, PC1
Adak, S; Bose, M; Mukherjee, S; Roy, J; Saha, R; Sen Santara, S1
Adak, S; Bose, M; Saha, R1
Adak, S; Bose, M; Roy, J; Saha, R; Santara, SS; Yadav, RK1
Ayaz, L; Canacankatan, N; Cuez, T; Gorur, A; Kacan, M; Kemal Buharalioglu, C; Korkmaz, B; Sahan Firat, S; Sari, AN; Sucu, N; Tamer Gumus, L; Tunctan, B; Unsal, D; Vezir, O1
Ding, Y; Wang, Q; Zhou, J; Zou, MH1
Chen, H; Duan, Q; Li, Y; Liang, X; Liu, H; Liu, L; Wang, D; Xie, K; Zhang, H1
Arnhold, J; Flemmig, J; Koyani, CN; Malle, E1
Kagan, VE; Kapralov, AA; Seo, W; Shurin, GV; Shurin, MR; Star, A1
Chen, Y; Deng, X; Ding, R; Feng, L; Fu, Z; Yang, S; Zeng, J1
Bauer, G; Heinzelmann, S1
Chen, J; Ding, Y; Lu, N; Tian, R; Yang, Z2
Buharalioglu, CK; Cecen, P; Gorur, A; Guden, DS; Kucukkavruk, SP; Malik, KU; Sahan-Firat, S; Sari, AN; Tamer-Gumus, L; Temiz-Resitoglu, M; Tunctan, B1
Beaudry, CM; Beckman, JS; Gallegos, MA; Hurst, JK; Padgitt-Cobb, L; Sirois, JJ1
Ding, Y; Lu, N; Peng, YY; Sui, Y; Tian, R1
Choromańska, B; Choromańska, K; Dadan, J; Maciejczyk, M; Myśliwiec, H; Myśliwiec, P; Wojskowicz, P; Zalewska, A; Łuba, M1
Marcinek, A; Michalski, R; Pierzchała, K; Pięta, J; Pięta, M; Rola, M; Sikora, A; Zielonka, J1

Reviews

2 review(s) available for peroxynitrous acid and mocetinostat

ArticleYear
Reactive nitrogen species in the chemical biology of inflammation.
    Archives of biochemistry and biophysics, 2004, Mar-01, Volume: 423, Issue:1

    Topics: Animals; DNA Damage; Humans; Inflammation; Oxygen; Peroxidase; Peroxynitrous Acid; Reactive Nitrogen Species

2004
Oxidative and nitrosative stress on phagocytes' function: from effective defense to immunity evasion mechanisms.
    Archivum immunologiae et therapiae experimentalis, 2011, Volume: 59, Issue:6

    Topics: Antioxidants; Candida albicans; Candida glabrata; Humans; Immune Evasion; Immunity, Innate; Macrophages; Malaria; Mycobacterium tuberculosis; Nitric Oxide; Oxidative Stress; Oxidoreductases; Peroxidase; Peroxynitrous Acid; Phagocytes; Reactive Oxygen Species; Respiratory Burst

2011

Other Studies

75 other study(ies) available for peroxynitrous acid and mocetinostat

ArticleYear
Role of peroxynitrite in macrophage microbicidal mechanisms in vivo revealed by protein nitration and hydroxylation.
    Free radical biology & medicine, 2001, Jun-01, Volume: 30, Issue:11

    Topics: Animals; Carbon Dioxide; Carbonates; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Electron Spin Resonance Spectroscopy; Free Radicals; Hydroxylation; Leishmania infantum; Leishmaniasis; Macrophage Activation; Macrophages; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Microscopy, Confocal; Microscopy, Fluorescence; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxidase; Peroxynitrous Acid; Tyrosine

2001
Protein tyrosine nitration in mouse peritoneal macrophages activated in vitro and in vivo: evidence against an essential role of peroxynitrite.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2001, Volume: 15, Issue:13

    Topics: Animals; Female; Free Radical Scavengers; Hydrogen Peroxide; Interferon-gamma; Lipopolysaccharides; Macrophage Activation; Macrophages, Peritoneal; Male; Metalloporphyrins; Mice; Mice, Inbred C57BL; Nitrates; Nitric Oxide; Nitrites; Peroxidase; Peroxynitrous Acid; Propionibacterium acnes; Proteins; Superoxides; Thioglycolates; Time Factors; Tyrosine

2001
Celecoxib, a selective cyclo-oxygenase-2 inhibitor reduces the severity of experimental colitis induced by dinitrobenzene sulfonic acid in rats.
    European journal of pharmacology, 2001, Nov-09, Volume: 431, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzenesulfonates; Body Weight; Celecoxib; Colitis; Colon; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cytokines; Immunohistochemistry; Intercellular Adhesion Molecule-1; Isoenzymes; Lipid Peroxidation; Male; Neutrophils; P-Selectin; Peroxidase; Peroxynitrous Acid; Poly(ADP-ribose) Polymerases; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Sprague-Dawley; Sulfonamides

2001
Deficiency of myeloperoxidase increases infarct volume and nitrotyrosine formation in mouse brain.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2002, Volume: 22, Issue:1

    Topics: Animals; Brain; Brain Infarction; Female; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Peroxidase; Peroxynitrous Acid; Reperfusion Injury; Time Factors; Tyrosine

2002
Direct real-time evaluation of nitration with green fluorescent protein in solution and within human cells reveals the impact of nitrogen dioxide vs. peroxynitrite mechanisms.
    Proceedings of the National Academy of Sciences of the United States of America, 2002, Mar-19, Volume: 99, Issue:6

    Topics: Buffers; Catalysis; Fluorescence; Green Fluorescent Proteins; Heme; Humans; Hydrogen Peroxide; Inhibitory Concentration 50; Luminescent Proteins; Nitrates; Nitric Oxide; Nitrogen Dioxide; Peroxidase; Peroxynitrous Acid; Rhodamines; Solutions; Superoxides; Time Factors; Tumor Cells, Cultured

2002
Novel phenanthridinone inhibitors of poly (adenosine 5'-diphosphate-ribose) synthetase: potent cytoprotective and antishock agents.
    Critical care medicine, 2002, Volume: 30, Issue:5

    Topics: Animals; Bleomycin; Cells, Cultured; Cytoprotection; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Interleukin-1; Kidney; Lipopolysaccharides; Lung; Malondialdehyde; Mice; Mice, Inbred BALB C; Nitrates; Nitrites; Peroxidase; Peroxynitrous Acid; Phenanthrenes; Poly(ADP-ribose) Polymerase Inhibitors; Rats; Rats, Wistar; Shock; Tumor Necrosis Factor-alpha

2002
Protein nitration is predominantly mediated by a peroxynitrite-dependent pathway in cultured human leucocytes.
    The Biochemical journal, 2002, Oct-15, Volume: 367, Issue:Pt 2

    Topics: Aniline Compounds; Cells, Cultured; Extracellular Space; Humans; Leukocytes; Metalloporphyrins; Nitrates; Peroxidase; Peroxynitrous Acid; Proteins; Spermine; Tetradecanoylphorbol Acetate; Tyrosine

2002
Concurrent formation of peroxynitrite with the expression of inducible nitric oxide synthase in the brain during middle cerebral artery occlusion and reperfusion in rats.
    Brain research, 2002, Sep-27, Volume: 951, Issue:1

    Topics: Animals; Cerebral Cortex; Cerebral Infarction; Cerebrovascular Circulation; Chemotaxis, Leukocyte; Disease Models, Animal; Hypoxia-Ischemia, Brain; Infarction, Middle Cerebral Artery; Male; Neutrophils; Nitric Oxide; Nitric Oxide Synthase; Peroxidase; Peroxynitrous Acid; Rats; Rats, Wistar; Reaction Time; Reperfusion Injury; Tyrosine

2002
Myeloperoxidase-associated tyrosine nitration after intratracheal administration of lipopolysaccharide in rats.
    Anesthesiology, 2002, Volume: 97, Issue:4

    Topics: Administration, Inhalation; Alkylating Agents; Animals; Antibody Specificity; Bronchoalveolar Lavage Fluid; Bronchodilator Agents; Cyclophosphamide; Immunohistochemistry; Leukocyte Count; Lipopolysaccharides; Lung; Male; Neutropenia; Neutrophils; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxidase; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Tyrosine

2002
Effects of calpain inhibitor I on multiple organ failure induced by zymosan in the rat.
    Critical care medicine, 2002, Volume: 30, Issue:10

    Topics: Animals; Calpain; Cell Movement; Cyclooxygenase 2; Dose-Response Relationship, Drug; Glycoproteins; Immunohistochemistry; Intestinal Mucosa; Intestines; Isoenzymes; Liver; Lung; Male; Malondialdehyde; Multiple Organ Failure; Neutrophils; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peritoneum; Peritonitis; Peroxidase; Peroxynitrous Acid; Poly Adenosine Diphosphate Ribose; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Tyrosine; Zymosan

2002
Urinary tract infection in iNOS-deficient mice with focus on bacterial sensitivity to nitric oxide.
    American journal of physiology. Renal physiology, 2003, Volume: 284, Issue:1

    Topics: Animals; Antibodies; Colony Count, Microbial; Escherichia coli; Escherichia coli Infections; Female; Genotype; Immunohistochemistry; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nephritis; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Peroxidase; Peroxynitrous Acid; Tyrosine; Urinary Tract Infections

2003
Critical role of reactive nitrogen species in lung ischemia-reperfusion injury.
    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2003, Volume: 22, Issue:7

    Topics: Animals; Bronchoalveolar Lavage Fluid; Capillary Permeability; Chemokines; Disease Models, Animal; Immunohistochemistry; Inflammation Mediators; Macrophages, Alveolar; Male; Models, Cardiovascular; NF-kappa B; Peroxidase; Peroxynitrous Acid; Rats; Rats, Long-Evans; Reactive Nitrogen Species; Reperfusion Injury; Respiratory Distress Syndrome; Severity of Illness Index; Statistics as Topic; Transcription Factor AP-1; Transcriptional Activation; Tyrosine

2003
Nicotine induces human neutrophils to produce IL-8 through the generation of peroxynitrite and subsequent activation of NF-kappaB.
    Journal of leukocyte biology, 2003, Volume: 74, Issue:5

    Topics: Humans; I-kappa B Proteins; Interleukin-8; Kinetics; Neutrophils; NF-kappa B; NF-KappaB Inhibitor alpha; NG-Nitroarginine Methyl Ester; Nicotine; Nitric Oxide; Peroxidase; Peroxynitrous Acid; Protein Transport; Reactive Oxygen Species; Smoking; Tumor Necrosis Factor-alpha

2003
Antioxidative properties of Iberis amara extracts in biochemical model reactions.
    Arzneimittel-Forschung, 2003, Volume: 53, Issue:8

    Topics: Adolescent; Adult; alpha-Linolenic Acid; Antioxidants; Brassicaceae; Chromatography, Gas; Ethylenes; Female; Humans; Hydroxyl Radical; In Vitro Techniques; Indicators and Reagents; Light; Lipid Peroxidation; Lipoproteins, LDL; Male; Models, Biological; Oxidation-Reduction; Peroxidase; Peroxynitrous Acid; Plant Extracts; Plants, Medicinal; Rose Bengal; Xanthine Oxidase

2003
8-Nitroxanthine, a product of myeloperoxidase, peroxynitrite, and activated human neutrophils, enhances generation of superoxide by xanthine oxidase.
    Archives of biochemistry and biophysics, 2003, Oct-01, Volume: 418, Issue:1

    Topics: Humans; Neutrophil Activation; Neutrophils; Peroxidase; Peroxynitrous Acid; Reperfusion Injury; Superoxides; Xanthine Oxidase; Xanthines

2003
Enzymatic nitration of phytophenolics: evidence for peroxynitrite-independent nitration of plant secondary metabolites.
    FEBS letters, 2003, Oct-23, Volume: 553, Issue:3

    Topics: Antioxidants; Ascorbic Acid; Coumaric Acids; Enzyme Inhibitors; Free Radicals; Horseradish Peroxidase; Nitrates; Nitrites; Nitrogen Dioxide; Peroxidase; Peroxynitrous Acid; Phenols; Plants; Potassium Cyanide; Spectrophotometry

2003
Bicarbonate enhances alpha-synuclein oligomerization and nitration: intermediacy of carbonate radical anion and nitrogen dioxide radical.
    The Biochemical journal, 2004, Mar-01, Volume: 378, Issue:Pt 2

    Topics: alpha-Synuclein; Anions; Bicarbonates; Cyclic N-Oxides; Dimerization; Free Radicals; Hydrogen Peroxide; Hydroxylation; Liposomes; Nerve Tissue Proteins; Nitric Oxide Donors; Nitrogen Dioxide; Nitrogen Oxides; Oxidation-Reduction; Peroxidase; Peroxynitrous Acid; Reactive Nitrogen Species; Spin Labels; Superoxide Dismutase; Superoxide Dismutase-1; Synucleins; Tyrosine

2004
Nitrotyrosine, dityrosine, and nitrotryptophan formation from metmyoglobin, hydrogen peroxide, and nitrite.
    Free radical biology & medicine, 2004, Mar-01, Volume: 36, Issue:5

    Topics: Hydrogen Peroxide; Methemoglobin; Metmyoglobin; Myoglobin; Nitrites; Peroxidase; Peroxynitrous Acid; Tryptophan; Tyrosine

2004
Methylguanidine reduces the development of non septic shock induced by zymosan in mice.
    Life sciences, 2004, Aug-06, Volume: 75, Issue:12

    Topics: Analysis of Variance; Animals; Disease Models, Animal; Exudates and Transudates; Immunohistochemistry; Intestinal Mucosa; Intestines; Kidney; Lipid Peroxidation; Lung; Male; Methylguanidine; Mice; Neutrophils; Pancreas; Peritonitis; Peroxidase; Peroxynitrous Acid; Poly(ADP-ribose) Polymerases; Shock; Tyrosine; Zymosan

2004
Nitric oxide generated from isoniazid activation by KatG: source of nitric oxide and activity against Mycobacterium tuberculosis.
    Antimicrobial agents and chemotherapy, 2004, Volume: 48, Issue:8

    Topics: Antitubercular Agents; Bacterial Proteins; Biotransformation; Catalase; Free Radical Scavengers; Isoniazid; Mycobacterium bovis; Mycobacterium tuberculosis; Nitric Oxide; Oxidoreductases; Peroxidase; Peroxynitrous Acid; Prodrugs; Spin Trapping; Tyrosine

2004
Human atherosclerotic intima and blood of patients with established coronary artery disease contain high density lipoprotein damaged by reactive nitrogen species.
    The Journal of biological chemistry, 2004, Oct-08, Volume: 279, Issue:41

    Topics: Arteries; Arteriosclerosis; Coronary Artery Disease; Coronary Vessels; Dose-Response Relationship, Drug; Epitopes; Gas Chromatography-Mass Spectrometry; Humans; Immunohistochemistry; Inflammation; Lipid Peroxides; Lipoproteins, HDL; Mass Spectrometry; Nitric Oxide; Nitrogen; Oxygen; Peroxidase; Peroxynitrous Acid; Reactive Nitrogen Species; Taurine; Time Factors; Tunica Intima; Tyrosine

2004
N-acetylcysteine inhibits peroxynitrite-mediated damage in oleic acid-induced lung injury.
    Pulmonary pharmacology & therapeutics, 2004, Volume: 17, Issue:5

    Topics: Acetylcysteine; Animals; Female; Lung; Malondialdehyde; Microscopy; Oleic Acid; Peroxidase; Peroxynitrous Acid; Rats; Rats, Wistar; Tyrosine

2004
Inducible nitric oxide synthase inhibitor reverses exacerbating effects of hypertonic saline on lung injury in burn.
    Shock (Augusta, Ga.), 2004, Volume: 22, Issue:5

    Topics: Animals; Burns; Dose-Response Relationship, Drug; Enzyme Inhibitors; Femoral Vein; Hot Temperature; Lung; Lung Diseases; Lung Injury; Neutrophils; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxygen; Peroxidase; Peroxynitrous Acid; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; Rhodamines; Saline Solution, Hypertonic; Sodium Chloride; Time Factors

2004
Tyrosine 192 in apolipoprotein A-I is the major site of nitration and chlorination by myeloperoxidase, but only chlorination markedly impairs ABCA1-dependent cholesterol transport.
    The Journal of biological chemistry, 2005, Feb-18, Volume: 280, Issue:7

    Topics: Amino Acid Sequence; Animals; Antioxidants; Apolipoprotein A-I; ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Chlorine; Cholesterol; Cricetinae; Electron Spin Resonance Spectroscopy; Humans; Hydrogen Peroxide; Hydrophobic and Hydrophilic Interactions; Nitrates; Nitrogen; Oxidation-Reduction; Peptides; Peroxidase; Peroxynitrous Acid; Spectrometry, Mass, Electrospray Ionization; Tyrosine

2005
Uric acid protects against secondary damage after spinal cord injury.
    Proceedings of the National Academy of Sciences of the United States of America, 2005, Mar-01, Volume: 102, Issue:9

    Topics: Animals; Cells, Cultured; Immunohistochemistry; Lipid Peroxidation; Male; Mice; Neurons; Neutrophils; Peroxidase; Peroxynitrous Acid; Spinal Cord Injuries; Uric Acid

2005
Analysis of dichlorodihydrofluorescein and dihydrocalcein as probes for the detection of intracellular reactive oxygen species.
    Free radical research, 2004, Volume: 38, Issue:12

    Topics: Angiotensin II; Animals; Aorta; Cells, Cultured; Cytoplasm; Electron Spin Resonance Spectroscopy; Electron Transport Complex I; Fluoresceins; Fluorescent Dyes; Half-Life; Mitochondria; Myocytes, Smooth Muscle; Oxidative Stress; Peroxidase; Peroxynitrous Acid; Rats; Reactive Oxygen Species

2004
Glycyrrhizae Radix attenuates peroxynitrite-induced renal oxidative damage through inhibition of protein nitration.
    Free radical research, 2005, Volume: 39, Issue:2

    Topics: Animals; Blood Urea Nitrogen; Chromium; Free Radical Scavengers; Glycyrrhiza; Kidney; Male; Mitochondria; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Oxidative Stress; Peroxidase; Peroxynitrous Acid; Plant Extracts; Rats; Rats, Wistar; Reactive Oxygen Species; Tyrosine

2005
Protective mechanisms of a metalloporphyrinic peroxynitrite decomposition catalyst, WW85, in rat cardiac transplants.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 314, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Apoptosis; Catalysis; Cyclosporine; Gene Expression; Graft Rejection; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Malondialdehyde; Metalloporphyrins; Myocardium; Neutrophils; Peroxidase; Peroxynitrous Acid; Poly Adenosine Diphosphate Ribose; Rats; Rats, Inbred Lew; Rats, Wistar; Tyrosine

2005
Time course and site(s) of cytochrome c tyrosine nitration by peroxynitrite.
    Biochemistry, 2005, Jun-07, Volume: 44, Issue:22

    Topics: Amino Acid Sequence; Animals; Cytochromes c; Electron Transport; Horses; Mitochondria, Heart; Molecular Sequence Data; Peroxidase; Peroxynitrous Acid; Potassium Cyanide; Rats; Sodium Cyanide; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tetranitromethane; Time Factors; Tyrosine

2005
Protective effect of trapidil against oxidative organ damage in burn injury.
    Burns : journal of the International Society for Burn Injuries, 2005, Volume: 31, Issue:7

    Topics: Animals; Burns; Lipid Peroxidation; Malondialdehyde; Oxidative Stress; Peroxidase; Peroxynitrous Acid; Protective Agents; Random Allocation; Rats; Rats, Wistar; Trapidil; Tumor Necrosis Factor-alpha; Tyrosine

2005
Nitrated and oxidized products of a single tryptophan residue in human Cu,Zn-superoxide dismutase treated with either peroxynitrite-carbon dioxide or myeloperoxidase-hydrogen peroxide-nitrite.
    Journal of biochemistry, 2005, Volume: 138, Issue:1

    Topics: Amino Acids; Chromatography, High Pressure Liquid; Humans; Hydrogen Peroxide; Hydrogen-Ion Concentration; Kinetics; Magnetic Resonance Spectroscopy; Mass Spectrometry; Oxidation-Reduction; Peptide Fragments; Peroxidase; Peroxynitrous Acid; Spectrometry, Fluorescence; Superoxide Dismutase; Tryptophan

2005
Peroxynitrite efficiently mediates the interconversion of redox intermediates of myeloperoxidase.
    Biochemical and biophysical research communications, 2005, Nov-25, Volume: 337, Issue:3

    Topics: Flow Injection Analysis; Iron; Nitrogen Oxides; Oxidation-Reduction; Peroxidase; Peroxynitrous Acid

2005
Thermal injury-induced peroxynitrite production and pulmonary inducible nitric oxide synthase expression depend on JNK/AP-1 signaling.
    Critical care medicine, 2006, Volume: 34, Issue:1

    Topics: Animals; Base Sequence; Biopsy, Needle; Blotting, Western; Burns; Disease Models, Animal; Immunohistochemistry; Intercellular Adhesion Molecule-1; Lung; Male; MAP Kinase Kinase 4; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Neutrophil Infiltration; Nitric Oxide Synthase; Peroxidase; Peroxynitrous Acid; Probability; Random Allocation; Reference Values; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sensitivity and Specificity; Signal Transduction; Transcription Factor AP-1; Vascular Cell Adhesion Molecule-1

2006
The effects of chronic exposure to ethanol and cigarette smoke on the formation of peroxynitrite, level of nitric oxide, xanthine oxidase and myeloperoxidase activities in rat kidney.
    Molecular and cellular biochemistry, 2006, Volume: 291, Issue:1-2

    Topics: Animals; Epithelial Cells; Ethanol; Immunohistochemistry; Inhalation Exposure; Kidney; Kidney Glomerulus; Kidney Tubules, Proximal; Leukocytes, Mononuclear; Male; Nitric Oxide; Peroxidase; Peroxynitrous Acid; Rats; Rats, Wistar; Smoking; Tyrosine; Xanthine Oxidase

2006
Oxidative and nitrative modifications of enkephalins by reactive nitrogen species.
    Free radical research, 2006, Volume: 40, Issue:7

    Topics: Animals; Cattle; Chromatography, High Pressure Liquid; Dimerization; Enkephalin, Leucine; Humans; Nitrites; Oxidation-Reduction; Peroxidase; Peroxynitrous Acid; Photochemistry; Reactive Nitrogen Species; Singlet Oxygen; Sodium Bicarbonate; Spectrometry, Mass, Electrospray Ionization

2006
Neutrophils do not mediate the pathophysiological sequelae of Cryptosporidium parvum infection in neonatal piglets.
    Infection and immunity, 2006, Volume: 74, Issue:10

    Topics: Animals; Antibodies; CD18 Antigens; Cryptosporidiosis; Cryptosporidium parvum; Diarrhea; Disease Models, Animal; Ileum; Immunoglobulin G; Intestinal Mucosa; Lipid Peroxidation; Neutrophils; Peroxidase; Peroxynitrous Acid; Prostaglandins; Superoxides; Swine

2006
Uncoupling of endothelial nitric oxidase synthase by hypochlorous acid: role of NAD(P)H oxidase-derived superoxide and peroxynitrite.
    Arteriosclerosis, thrombosis, and vascular biology, 2006, Volume: 26, Issue:12

    Topics: Animals; Atherosclerosis; Cells, Cultured; Endothelium, Vascular; Female; Humans; Hypochlorous Acid; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; NADPH Oxidase 2; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidants; Oxygen; Peroxidase; Peroxynitrous Acid; Phosphoproteins; Superoxides; Tyrosine; Uncoupling Agents

2006
Neutrophils-derived peroxynitrite contributes to acute hyperalgesia and cell influx in zymosan arthritis.
    Naunyn-Schmiedeberg's archives of pharmacology, 2007, Volume: 374, Issue:4

    Topics: Acute Disease; Animals; Arthritis, Experimental; Hindlimb; Hyperalgesia; Injections, Intra-Articular; Knee Joint; Male; Neutrophils; Nitric Oxide; Peroxidase; Peroxynitrous Acid; Rats; Rats, Wistar; Reactive Nitrogen Species; Synovial Fluid; Tyrosine; Uric Acid; Zymosan

2007
Interleukin-1 mediates thermal injury-induced lung damage through C-Jun NH2-terminal kinase signaling.
    Critical care medicine, 2007, Volume: 35, Issue:4

    Topics: Animals; Anthracenes; Burns; Chemokine CXCL2; Intercellular Adhesion Molecule-1; Interleukin-1; JNK Mitogen-Activated Protein Kinases; Lung; Lung Diseases; Mice; Mice, Knockout; Monokines; Neutrophils; Nitric Oxide Synthase Type II; Peroxidase; Peroxynitrous Acid; Receptors, Interleukin-1 Type I; Receptors, Interleukin-8B; Receptors, Tumor Necrosis Factor, Type I; RNA, Messenger; Signal Transduction; Vascular Cell Adhesion Molecule-1

2007
Efficiency of lornoxicam in lung and trachea injury caused by peroxynitrite.
    Pulmonary pharmacology & therapeutics, 2008, Volume: 21, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bronchoalveolar Lavage Fluid; Female; Lung; Male; Malondialdehyde; Peroxidase; Peroxynitrous Acid; Piroxicam; Rats; Respiratory Distress Syndrome; Trachea; Tracheal Diseases; Tyrosine

2008
Peroxynitrite decomposition catalyst FeTMPyP provides partial protection against intestinal ischemia and reperfusion injury in infant rats.
    Pediatric research, 2007, Volume: 62, Issue:1

    Topics: Animals; Animals, Suckling; Endothelial Cells; Glutathione; Intercellular Adhesion Molecule-1; Intestinal Mucosa; Intestines; Ischemia; Malondialdehyde; Metalloporphyrins; Nitrates; Nitrites; P-Selectin; Peroxidase; Peroxynitrous Acid; Random Allocation; Rats; Reperfusion Injury; Vascular Cell Adhesion Molecule-1

2007
Beneficial effects of FeTSPP, a peroxynitrite decomposition catalyst, in a mouse model of spinal cord injury.
    Free radical biology & medicine, 2007, Sep-01, Volume: 43, Issue:5

    Topics: Animals; Catalysis; Disease Models, Animal; DNA; I-kappa B Proteins; Interleukin-1beta; Interleukin-2; Lipid Peroxidation; Male; Metalloporphyrins; Mice; Mitochondria; Neutrophil Infiltration; NF-kappa B; Peroxidase; Peroxynitrous Acid; Phosphorylation; Poly(ADP-ribose) Polymerases; Protein Transport; Proto-Oncogene Proteins c-bcl-2; RNA; Spinal Cord Injuries; T-Lymphocytes; Tumor Necrosis Factor-alpha; Tyrosine

2007
Loss of 3-chlorotyrosine by inflammatory oxidants: implications for the use of 3-chlorotyrosine as a bio-marker in vivo.
    Biochemical and biophysical research communications, 2008, Jun-20, Volume: 371, Issue:1

    Topics: Animals; Biomarkers; HL-60 Cells; Humans; Hypochlorous Acid; Inflammation; Macrophage Activation; Macrophages; Mice; Neutrophils; Nitrites; Oxidants; Peroxidase; Peroxynitrous Acid; Reactive Oxygen Species; Tyrosine

2008
Differential contribution of neutrophilic granulocytes and macrophages to nitrosative stress in a host-parasite animal model.
    Molecular immunology, 2008, Volume: 45, Issue:11

    Topics: Animals; B-Lymphocytes; Carps; Cell Death; Gene Expression Regulation, Enzymologic; Host-Parasite Interactions; Macrophages; Melarsoprol; Models, Animal; Neutrophils; Nitric Oxide; Nitric Oxide Synthase Type II; Nitrites; Parasitemia; Parasites; Peroxidase; Peroxynitrous Acid; Reactive Nitrogen Species; Spleen; Stress, Physiological; Trypanosoma; Trypanosomiasis; Tyrosine

2008
Dose dependence and therapeutic window for the neuroprotective effects of curcumin in thromboembolic model of rat.
    Behavioural brain research, 2008, Nov-21, Volume: 193, Issue:2

    Topics: Animals; Behavior, Animal; Brain Edema; Brain Ischemia; Cerebrovascular Circulation; Curcumin; Disease Models, Animal; Dose-Response Relationship, Drug; Glutathione Peroxidase; Immunohistochemistry; Infarction, Middle Cerebral Artery; Male; Motor Activity; Neuroprotective Agents; Nitrates; Nitric Oxide; Nitrites; Peroxidase; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Treatment Outcome

2008
Role of TNF-alpha-induced reactive oxygen species in endothelial dysfunction during reperfusion injury.
    American journal of physiology. Heart and circulatory physiology, 2008, Volume: 295, Issue:6

    Topics: Animals; Antibodies; Coronary Circulation; Coronary Vessels; Disease Models, Animal; Endothelium, Vascular; Female; Male; Mice; Microcirculation; Muscle, Smooth, Vascular; Myocardial Reperfusion Injury; NADPH Oxidases; Neutropenia; Nitric Oxide; Oxidative Stress; Peroxidase; Peroxynitrous Acid; Reactive Oxygen Species; RNA, Messenger; Superoxides; Tumor Necrosis Factor-alpha; Vasodilation; Xanthine Oxidase

2008
Lung-protective effects of the metalloporphyrinic peroxynitrite decomposition catalyst WW-85 in interleukin-2 induced toxicity.
    Biochemical and biophysical research communications, 2008, Dec-19, Volume: 377, Issue:3

    Topics: Animals; Capillary Leak Syndrome; Capillary Permeability; Catalysis; Hemodynamics; Interleukin-2; Lung; Lymph; Malondialdehyde; Neoplasms; Nitric Oxide; Nitric Oxide Synthase Type II; Peroxidase; Peroxynitrous Acid; Pulmonary Gas Exchange; Recombinant Proteins; Sheep; Tyrosine

2008
The effect of neighboring methionine residue on tyrosine nitration and oxidation in peptides treated with MPO, H2O2, and NO2(-) or peroxynitrite and bicarbonate: role of intramolecular electron transfer mechanism?
    Archives of biochemistry and biophysics, 2009, Apr-15, Volume: 484, Issue:2

    Topics: Acetylation; Bicarbonates; Electron Spin Resonance Spectroscopy; Electron Transport; Hydrogen Peroxide; Kinetics; Methionine; Nitrates; Peptides; Peroxidase; Peroxynitrous Acid; Reactive Nitrogen Species; Tyrosine

2009
Oxidation and nitration of ribonuclease and lysozyme by peroxynitrite and myeloperoxidase.
    Archives of biochemistry and biophysics, 2009, Apr-15, Volume: 484, Issue:2

    Topics: Animals; Cattle; Chickens; Chromatography, High Pressure Liquid; Egg White; Free Radicals; Hydrogen Peroxide; Inflammation; Muramidase; Peroxidase; Peroxynitrous Acid; Pronase; Proteins; Ribonucleases; Spectrometry, Mass, Electrospray Ionization; Spleen; Tyrosine

2009
Effects of a metalloporphyrinic peroxynitrite decomposition catalyst, ww-85, in a mouse model of spinal cord injury.
    Free radical research, 2009, Volume: 43, Issue:7

    Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Cytokines; Disease Models, Animal; Immunoenzyme Techniques; In Situ Nick-End Labeling; Lipid Peroxidation; Male; Mice; Motor Activity; Neutrophil Infiltration; NF-kappa B; Peroxidase; Peroxynitrous Acid; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Spinal Cord Injuries; Thiobarbituric Acid Reactive Substances; Tyrosine

2009
Myeloperoxidase interaction with peroxynitrite: chloride deficiency and heme depletion.
    Free radical biology & medicine, 2009, Aug-15, Volume: 47, Issue:4

    Topics: Alkalosis; Allosteric Regulation; Breast Feeding; Chlorides; Chromatography, High Pressure Liquid; Female; Heme; Humans; Immunity, Cellular; In Vitro Techniques; Infant; Leukocytes; Oxidative Stress; Peroxidase; Peroxynitrous Acid; Protein Binding; Smoking

2009
Superoxide radical protects liposome-contained cytochrome c against oxidative damage promoted by peroxynitrite and free radicals.
    Free radical biology & medicine, 2009, Sep-15, Volume: 47, Issue:6

    Topics: Cytochromes c; Electron Spin Resonance Spectroscopy; Heme; Lipid Peroxidation; Nitrosation; Oxidation-Reduction; Oxidative Stress; Peroxidase; Peroxynitrous Acid; Protein Processing, Post-Translational; Protein Structure, Secondary; Spectrophotometry; Superoxides; Tryptophan; Unilamellar Liposomes

2009
Comparative study of HOCl-inflicted damage to bacterial DNA ex vivo and within cells.
    Archives of biochemistry and biophysics, 2010, Jan-15, Volume: 493, Issue:2

    Topics: Azides; DNA Breaks, Single-Stranded; DNA Fragmentation; DNA, Bacterial; Dose-Response Relationship, Drug; Escherichia coli K12; Humans; Hypochlorous Acid; Neutrophils; Oxidants; Peroxidase; Peroxynitrous Acid; Phagocytosis; Plasmids; Uracil

2010
The peroxynitrite catalyst WW-85 improves pulmonary function in ovine septic shock.
    Shock (Augusta, Ga.), 2011, Volume: 35, Issue:2

    Topics: Acute Lung Injury; Animals; Catalysis; Disease Models, Animal; Female; Lung; Malondialdehyde; Nitrates; Peroxidase; Peroxynitrous Acid; Pulmonary Gas Exchange; Respiratory Function Tests; Sheep; Shock, Septic

2011
Beneficial pulmonary effects of a metalloporphyrinic peroxynitrite decomposition catalyst in burn and smoke inhalation injury.
    American journal of physiology. Lung cellular and molecular physiology, 2011, Volume: 300, Issue:2

    Topics: Animals; Burns; Capillary Permeability; Catalysis; Disease Models, Animal; Female; Hemodynamics; Interleukin-8; Lung; Metalloporphyrins; Peroxidase; Peroxynitrous Acid; Poly(ADP-ribose) Polymerases; Pulmonary Circulation; Sheep; Smoke Inhalation Injury; Tyrosine; Vascular Endothelial Growth Factor A

2011
Effects of a potent peroxynitrite decomposition catalyst in murine models of endotoxemia and sepsis.
    Shock (Augusta, Ga.), 2011, Volume: 35, Issue:6

    Topics: Animals; Endotoxemia; Lipopolysaccharides; Malondialdehyde; Metalloporphyrins; Mice; Nitrates; Nitrites; Peroxidase; Peroxynitrous Acid; Sepsis

2011
AMP-activated protein kinase deficiency reduces ozone-induced lung injury and oxidative stress in mice.
    Respiratory research, 2011, May-19, Volume: 12

    Topics: AMP-Activated Protein Kinases; Animals; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Enzyme Activation; Extravascular Lung Water; Inflammation Mediators; Lung; Lung Injury; Male; Malondialdehyde; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxidative Stress; Ozone; Peroxidase; Peroxynitrous Acid; Phosphorylation; Pneumonia; Pulmonary Alveoli; Sodium-Potassium-Exchanging ATPase; Time Factors

2011
Inhibition of peroxynitrite- and peroxidase-mediated protein tyrosine nitration by imidazole-based thiourea and selenourea derivatives.
    Organic & biomolecular chemistry, 2011, Nov-07, Volume: 9, Issue:21

    Topics: Animals; Cattle; Crystallography, X-Ray; Imidazoles; Models, Molecular; Molecular Structure; Nitrates; Organoselenium Compounds; Peroxidase; Peroxynitrous Acid; Serum Albumin, Bovine; Stereoisomerism; Thiourea; Tyrosine; Urea

2011
Protection against peroxynitrite by pseudoperoxidase from Leishmania major.
    Free radical biology & medicine, 2012, Nov-15, Volume: 53, Issue:10

    Topics: Amino Acid Sequence; Animals; Cell Line; Cell Membrane; Female; Hydrogen Peroxide; Leishmania major; Leishmaniasis, Cutaneous; Macrophage Activation; Macrophages; Membrane Proteins; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Molsidomine; Peroxidase; Peroxynitrous Acid; Protozoan Proteins

2012
Mutation of Val90 to His in the pseudoperoxidase from Leishmania major enhances peroxidase activity.
    Biochimica et biophysica acta, 2013, Volume: 1834, Issue:3

    Topics: Amino Acid Sequence; Amino Acid Substitution; Binding Sites; Biocatalysis; Electrophoresis, Polyacrylamide Gel; Histidine; Hydrogen Peroxide; Kinetics; Leishmania major; Models, Molecular; Molecular Sequence Data; Mutant Proteins; Mutation; Oxidation-Reduction; Peroxidase; Peroxynitrous Acid; Protein Structure, Tertiary; Protozoan Proteins; Sequence Homology, Amino Acid; Spectrophotometry; Valine

2013
Effect of distal His mutation on the peroxynitrite reactivity of Leishmania major peroxidase.
    Biochimica et biophysica acta, 2013, Volume: 1834, Issue:10

    Topics: Biocatalysis; Electron Spin Resonance Spectroscopy; Enzyme Assays; Escherichia coli; Gene Expression; Histidine; Hydrogen Peroxide; Kinetics; Leishmania major; Mutation; Oxidation-Reduction; Peroxidase; Peroxynitrous Acid; Protozoan Proteins; Recombinant Proteins

2013
Contribution of RhoA/Rho-kinase/MEK1/ERK1/2/iNOS pathway to ischemia/reperfusion-induced oxidative/nitrosative stress and inflammation leading to distant and target organ injury in rats.
    European journal of pharmacology, 2014, Jan-15, Volume: 723

    Topics: Amides; Animals; Catalase; Glutathione; Inflammation; Kidney; Male; Malondialdehyde; MAP Kinase Kinase 1; MAP Kinase Signaling System; Muscle, Skeletal; NADPH Oxidases; Nitric Oxide Synthase Type II; Oxidative Stress; Peroxidase; Peroxynitrous Acid; Pyridines; Rats; Rats, Wistar; Reperfusion Injury; rho-Associated Kinases; rhoA GTP-Binding Protein; Superoxide Dismutase; Tyrosine

2014
Hypochlorous acid via peroxynitrite activates protein kinase Cθ and insulin resistance in adipocytes.
    Journal of molecular endocrinology, 2015, Volume: 54, Issue:1

    Topics: 3T3-L1 Cells; Adipocytes; Animals; Glucose Transporter Type 4; Hypochlorous Acid; I-kappa B Kinase; Insulin Receptor Substrate Proteins; Insulin Resistance; Isoenzymes; JNK Mitogen-Activated Protein Kinases; Mice; Peroxidase; Peroxynitrous Acid; Phosphorylation; Protein Kinase C; Protein Kinase C-theta; Protein Processing, Post-Translational; Protein Transport; Signal Transduction

2015
Combination therapy with nitric oxide and molecular hydrogen in a murine model of acute lung injury.
    Shock (Augusta, Ga.), 2015, Volume: 43, Issue:5

    Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Gases; Hydrogen; Lipopolysaccharides; Lung; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Nitric Oxide; Oxygen; Peroxidase; Peroxynitrous Acid; Sepsis; Time Factors

2015
Myeloperoxidase scavenges peroxynitrite: A novel anti-inflammatory action of the heme enzyme.
    Archives of biochemistry and biophysics, 2015, Apr-01, Volume: 571

    Topics: Aniline Compounds; Anti-Inflammatory Agents; Catechin; Fluoresceins; Halogenation; Humans; Hydrogen Peroxide; Hydrogen-Ion Concentration; Kinetics; Molsidomine; Nitrites; Oxidants; Oxidation-Reduction; Peroxidase; Peroxynitrous Acid; Tyrosine

2015
Payload drug vs. nanocarrier biodegradation by myeloperoxidase- and peroxynitrite-mediated oxidations: pharmacokinetic implications.
    Nanoscale, 2015, May-21, Volume: 7, Issue:19

    Topics: Animals; Antibiotics, Antineoplastic; Biocatalysis; Cell Line, Tumor; Cell Survival; Doxorubicin; Drug Carriers; Humans; Hydrogen-Ion Concentration; Mice; Nanotubes, Carbon; Oxidation-Reduction; Peroxidase; Peroxynitrous Acid

2015
P2X7R blockade prevents NLRP3 inflammasome activation and brain injury in a rat model of intracerebral hemorrhage: involvement of peroxynitrite.
    Journal of neuroinflammation, 2015, Oct-17, Volume: 12

    Topics: Animals; Apoptosis Regulatory Proteins; Brain Edema; Brain Injuries; CARD Signaling Adaptor Proteins; Carrier Proteins; Caspase 1; Cerebral Hemorrhage; Cytokines; Disease Models, Animal; Male; Membrane Glycoproteins; NADPH Oxidase 2; NADPH Oxidases; Nitric Oxide Synthase Type II; NLR Family, Pyrin Domain-Containing 3 Protein; Peroxidase; Peroxynitrous Acid; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2X7; Time Factors; Up-Regulation

2015
Site-specific Effects of DUOX1-Related Peroxidase on Intercellular Apoptosis Signaling.
    Anticancer research, 2015, Volume: 35, Issue:11

    Topics: Animals; Apoptosis; Blotting, Western; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Dipeptides; Dual Oxidases; Fibroblasts; Flow Cytometry; Humans; Hypochlorous Acid; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; NADH, NADPH Oxidoreductases; NADPH Oxidase 1; NADPH Oxidases; Nitric Oxide; Oxidants; Peroxidase; Peroxynitrous Acid; Rats; RNA, Small Interfering; Signal Transduction; Stomach Neoplasms; Superoxide Dismutase; Superoxides; Transforming Growth Factor beta

2015
NADPH oxidase-dependent degradation of single-walled carbon nanotubes in macrophages.
    Journal of materials science. Materials in medicine, 2017, Volume: 28, Issue:1

    Topics: Biocompatible Materials; Cell Line; Humans; Immunoglobulin G; Macrophages; Microscopy, Electron, Transmission; NADPH Oxidases; Nanotechnology; Nanotubes, Carbon; Neutrophils; Oxidation-Reduction; Oxygen; Peroxidase; Peroxynitrous Acid; Reactive Oxygen Species

2017
Effects of serum albumin on the degradation and cytotoxicity of single-walled carbon nanotubes.
    Biophysical chemistry, 2017, Volume: 222

    Topics: Adsorption; Animals; Cattle; Hydrophobic and Hydrophilic Interactions; Nanotubes, Carbon; Peroxidase; Peroxynitrous Acid; Protein Binding; Serum Albumin; Serum Albumin, Bovine

2017
Activation of mTOR/IκB-α/NF-κB pathway contributes to LPS-induced hypotension and inflammation in rats.
    European journal of pharmacology, 2017, May-05, Volume: 802

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arterial Pressure; Cyclooxygenase 2; Epoprostenol; Gene Expression Regulation, Enzymologic; Heart Rate; Hypotension; I-kappa B Proteins; Inflammation; Lipopolysaccharides; Male; Nitric Oxide; Nitric Oxide Synthase Type II; Peroxidase; Peroxynitrous Acid; Rats; Rats, Wistar; Ribosomal Protein S6; Signal Transduction; TOR Serine-Threonine Kinases; Transcription Factor RelA; Tumor Necrosis Factor-alpha; Tyrosine

2017
Oxidative Release of Copper from Pharmacologic Copper Bis(thiosemicarbazonato) Compounds.
    Inorganic chemistry, 2018, Aug-06, Volume: 57, Issue:15

    Topics: Coordination Complexes; Copper; Horseradish Peroxidase; Hydrogen Peroxide; Hypochlorous Acid; Ligands; Oxidation-Reduction; Peroxidase; Peroxynitrous Acid; Thiosemicarbazones

2018
Fibrinogen binding-dependent cytotoxicity and degradation of single-walled carbon nanotubes.
    Journal of materials science. Materials in medicine, 2018, Jul-17, Volume: 29, Issue:8

    Topics: Adsorption; Biocompatible Materials; Cell Line; Fibrinogen; Humans; Inflammation; Macrophages; Microscopy, Atomic Force; Nanotubes, Carbon; Oxidation-Reduction; Peroxidase; Peroxynitrous Acid; Protein Binding

2018
The Impact of Hypertension and Metabolic Syndrome on Nitrosative Stress and Glutathione Metabolism in Patients with Morbid Obesity.
    Oxidative medicine and cellular longevity, 2020, Volume: 2020

    Topics: Adult; Area Under Curve; Female; Glutathione; Glutathione Disulfide; Humans; Hypertension; Metabolic Syndrome; Middle Aged; Nitric Oxide; Nitrosative Stress; Obesity, Morbid; Oxidation-Reduction; Peroxidase; Peroxynitrous Acid; ROC Curve; Sulfhydryl Compounds; Tyrosine

2020
Boronate-Based Oxidant-Responsive Derivatives of Acetaminophen as Proinhibitors of Myeloperoxidase.
    Chemical research in toxicology, 2023, 08-21, Volume: 36, Issue:8

    Topics: Acetaminophen; Humans; Hydrogen Peroxide; Hypochlorous Acid; Oxidants; Oxidation-Reduction; Peroxidase; Peroxynitrous Acid

2023