Page last updated: 2024-09-03

peroxynitrous acid and melatonin

peroxynitrous acid has been researched along with melatonin in 22 studies

Compound Research Comparison

Studies
(peroxynitrous acid)
Trials
(peroxynitrous acid)
Recent Studies (post-2010)
(peroxynitrous acid)
Studies
(melatonin)
Trials
(melatonin)
Recent Studies (post-2010) (melatonin)
3,303211,23023,2681,4519,627

Protein Interaction Comparison

ProteinTaxonomyperoxynitrous acid (IC50)melatonin (IC50)
MyeloperoxidaseHomo sapiens (human)3
Ribosyldihydronicotinamide dehydrogenase [quinone]Homo sapiens (human)3.3323
Metabotropic glutamate receptor 1Rattus norvegicus (Norway rat)0.0004
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)0.0005
Melatonin receptor type 1AHomo sapiens (human)0.0025
Melatonin receptor type 1BHomo sapiens (human)0.0035

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's14 (63.64)29.6817
2010's6 (27.27)24.3611
2020's2 (9.09)2.80

Authors

AuthorsStudies
Caputi, AP; Cuzzocrea, S; De Sarro, A; Dugo, L; Fulia, F; Serraino, I1
Manchester, LC; Qi, W; Reiter, RJ; Tan, DX1
Cakýcý, Y; Kanzýk, Y; Sariahmetoglu, M; Townshend, A; Wheatley, RA1
Charão, CC; Creczynski-Pasa, TB; de Cordova, CA; de Lima, VR; Morfim, MP; Teixeira, A1
Li, Q; Ling, YL; Zhou, JL; Zhu, XG1
Autore, G; Cuzzocrea, S; d'Emmanuele di Villa Bianca, R; Di Paola, R; Marzocco, S; Pinto, A; Sorrentino, R1
Cuzzocrea, S; Salvemini, D; Thiemermann, C1
Desole, MS; Esposito, G; Marchetti, B; Miele, E; Migheli, R; Mura, MP; Rocchitta, G; Serra, PA1
Aydogan, S; Goktas, A; Yerer, MB1
Chen, JG; Liu, YH; Shu, BH; Wang, JZ; Xu, YF; Yin, J; Zhang, YJ1
Ducrocq, C; Houée-Levin, C; Peyrot, F1
Kirsch, M; Lehnig, M1
Ducrocq, C; Peyrot, F1
Fatokun, AA; Smith, RA; Stone, TW1
Bramanti, P; Cuzzocrea, S; Esposito, E; Mazzon, E; Paterniti, I1
Chen, YX; Fukunaga, K; Han, F; Hong, ZH; Liu, LL; Lou, YJ; Lu, YM; Tao, RR; Zhang, GS1
Fernández-Moreira, D; García Ruiz, I; García-Consuegra, I; Gómez-Izquierdo, E; Muñoz-Yagüe, T; Solís-Herruzo, JA; Solís-Muñoz, P1
Chen, YX; Fukunaga, K; Han, F; Huang, JY; Ji, YL; Liao, MH; Lu, YM; Qin, ZH; Tao, RR; Zhang, GS1
Costa, RC; Harasimowicz, J; Marques, KL; Prior, JA; Rodrigues, SS; Santos, JL; Silva, AF1
Gibbons, NC; Lüdemann, J; Martinez, A; Rokos, H; Salem, MA; Schallreuter, KU; Slominski, R1
Bozdağ, Z; Bozdayi, MA; Demir, M; Ince, O; Kalyoncu, Ş; Taysi, S; Tuncer, M; Ulusal, H; Yilmaz, B1
Cai, Y; Cao, Y; Li, R; Li, W; Liu, H1

Reviews

4 review(s) available for peroxynitrous acid and melatonin

ArticleYear
Biochemical reactivity of melatonin with reactive oxygen and nitrogen species: a review of the evidence.
    Cell biochemistry and biophysics, 2001, Volume: 34, Issue:2

    Topics: Animals; Anions; Antioxidants; Humans; Hydrogen Peroxide; Hypochlorous Acid; Melatonin; Models, Biological; Models, Chemical; Nitric Oxide; Oxygen; Peroxynitrous Acid; Reactive Nitrogen Species; Reactive Oxygen Species

2001
Potential therapeutic effect of antioxidant therapy in shock and inflammation.
    Current medicinal chemistry, 2004, Volume: 11, Issue:9

    Topics: Animals; Antioxidants; Free Radical Scavengers; Glutathione; Humans; Inflammation; Melatonin; Oxidative Stress; Peroxynitrous Acid; Poly(ADP-ribose) Polymerase Inhibitors; Reactive Nitrogen Species; Reactive Oxygen Species; Shock; Structure-Activity Relationship; Superoxide Dismutase

2004
Melatonin and nitric oxide.
    Journal of endocrinological investigation, 2006, Volume: 29, Issue:3

    Topics: Aging; Animals; Antioxidants; Free Radical Scavengers; Humans; Lipid Peroxidation; Melatonin; Nitric Oxide; Nitric Oxide Synthase; Oxidants; Oxidative Stress; Peroxynitrous Acid

2006
Potential role of tryptophan derivatives in stress responses characterized by the generation of reactive oxygen and nitrogen species.
    Journal of pineal research, 2008, Volume: 45, Issue:3

    Topics: Animals; Antioxidants; Carcinogens; Humans; Kynuramine; Kynurenine; Melatonin; Mutagens; Nitric Oxide Donors; Nitrogen Dioxide; Nitroso Compounds; Oxidation-Reduction; Peroxynitrous Acid; Reactive Nitrogen Species; Reactive Oxygen Species; Serotonin; Stress, Physiological; Tryptophan

2008

Other Studies

18 other study(ies) available for peroxynitrous acid and melatonin

ArticleYear
Effect of melatonin on cellular energy depletion mediated by peroxynitrite and poly (ADP-ribose) synthetase activation in an acute model of inflammation.
    Journal of pineal research, 2001, Volume: 31, Issue:1

    Topics: Acute Disease; Animals; Carrageenan; Disease Models, Animal; DNA Damage; Energy Metabolism; Enzyme Activation; Inflammation; Macrophages; Male; Melatonin; NAD; Peroxynitrous Acid; Pleurisy; Poly(ADP-ribose) Polymerases; Rats; Rats, Sprague-Dawley

2001
Evaluation of the antioxidant effect of melatonin by flow injection analysis-luminol chemiluminescence.
    Pharmacological research, 2003, Volume: 48, Issue:4

    Topics: Antioxidants; Flow Injection Analysis; Hydrogen Peroxide; Hydroxyl Radical; Luminescent Measurements; Luminol; Melatonin; Peroxynitrous Acid; Serotonin; Sodium Hypochlorite; Solutions; Superoxides; Tryptophan; Water

2003
Melatonin protects against pro-oxidant enzymes and reduces lipid peroxidation in distinct membranes induced by the hydroxyl and ascorbyl radicals and by peroxynitrite.
    Journal of pineal research, 2003, Volume: 35, Issue:4

    Topics: Cell Membrane; Free Radicals; Lipid Metabolism; Lipid Peroxidation; Melatonin; Oxidants; Peroxynitrous Acid

2003
Melatonin reduces peroxynitrite-induced injury in aortic smooth muscle cells.
    Acta pharmacologica Sinica, 2004, Volume: 25, Issue:2

    Topics: Animals; Aorta; Cell Survival; Cells, Cultured; DNA Damage; Free Radical Scavengers; Malondialdehyde; Melatonin; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Tyrosine

2004
Melatonin prevents lipopolysaccharide-induced hyporeactivity in rat.
    Journal of pineal research, 2004, Volume: 36, Issue:3

    Topics: Animals; Aorta; Endothelium, Vascular; In Vitro Techniques; Lipopolysaccharides; Male; Melatonin; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Phenylephrine; Poly(ADP-ribose) Polymerases; Rats; Rats, Wistar; Reactive Oxygen Species; Shock, Septic; Vasoconstriction

2004
Role of endogenous melatonin in the oxidative homeostasis of the extracellular striatal compartment: a microdialysis study in PC12 cells in vitro and in the striatum of freely moving rats.
    Journal of pineal research, 2005, Volume: 39, Issue:4

    Topics: Animals; Corpus Striatum; Dehydroascorbic Acid; Dopamine; Homeostasis; Light; Male; Melatonin; Microdialysis; Molsidomine; PC12 Cells; Peroxynitrous Acid; Rats; Rats, Wistar

2005
Melatonin arrests peroxynitrite-induced tau hyperphosphorylation and the overactivation of protein kinases in rat brain.
    Journal of pineal research, 2006, Volume: 41, Issue:2

    Topics: Animals; Glycogen Synthase Kinase 3; Hippocampus; Male; Melatonin; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Peroxynitrous Acid; Phosphorylation; Rats; Rats, Wistar; Superoxide Dismutase; tau Proteins; Uric Acid

2006
Melatonin nitrosation promoted by NO*2; comparison with the peroxynitrite reaction.
    Free radical research, 2006, Volume: 40, Issue:9

    Topics: Free Radicals; Gamma Rays; Hydrogen-Ion Concentration; Melatonin; Molecular Structure; Nitrogen Dioxide; Nitrosation; Oxidation-Reduction; Peroxynitrous Acid

2006
15N-CIDNP investigations during tryptophan, N-acetyl-L-tryptophan, and melatonin nitration with reactive nitrogen species.
    Free radical research, 2007, Volume: 41, Issue:5

    Topics: Magnetic Resonance Spectroscopy; Melatonin; Molecular Structure; Nitrates; Nitrogen; Peroxynitrous Acid; Photochemistry; Reactive Nitrogen Species; Tryptophan

2007
Prolonged exposures of cerebellar granule neurons to S-nitroso-N-acetylpenicillamine (SNAP) induce neuronal damage independently of peroxynitrite.
    Brain research, 2008, Sep-16, Volume: 1230

    Topics: Animals; Cell Death; Cell Survival; Cerebellum; Cyclosporine; Cytoplasmic Granules; Data Interpretation, Statistical; Free Radical Scavengers; Hemoglobins; Hydroquinones; Melatonin; Mitochondrial Membranes; Neurons; Nitric Oxide Donors; Peroxynitrous Acid; Poly Adenosine Diphosphate Ribose; Rats; Rats, Sprague-Dawley; S-Nitroso-N-Acetylpenicillamine; Superoxide Dismutase; Uric Acid

2008
Melatonin reduces hyperalgesia associated with inflammation.
    Journal of pineal research, 2010, Volume: 49, Issue:4

    Topics: Animals; Cyclooxygenase 2; Disease Models, Animal; Hyperalgesia; Immunohistochemistry; Inflammation; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Melatonin; Mitogen-Activated Protein Kinases; NF-kappa B; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Signal Transduction; Superoxides; Tyrosine

2010
Melatonin ameliorates ischemic-like injury-evoked nitrosative stress: Involvement of HtrA2/PED pathways in endothelial cells.
    Journal of pineal research, 2011, Volume: 50, Issue:3

    Topics: Animals; Apoptosis Regulatory Proteins; Brain Ischemia; Cell Line; Cell Survival; Endothelial Cells; Flow Cytometry; High-Temperature Requirement A Serine Peptidase 2; Humans; Immunoblotting; Immunoprecipitation; Intracellular Signaling Peptides and Proteins; Male; Melatonin; Membrane Potential, Mitochondrial; Microscopy, Confocal; Mitochondrial Proteins; Nerve Tissue Proteins; Peroxynitrous Acid; Phosphoproteins; Rats; Rats, Wistar; RNA-Binding Proteins; Serine Endopeptidases; Serine-Arginine Splicing Factors; Signal Transduction

2011
Melatonin improves mitochondrial respiratory chain activity and liver morphology in ob/ob mice.
    Journal of pineal research, 2011, Volume: 51, Issue:1

    Topics: Animals; Blotting, Western; Body Weight; Electron Transport Chain Complex Proteins; Fatty Liver; Histocytochemistry; Liver; Male; Melatonin; Mice; Mice, Inbred C57BL; Mice, Obese; Mitochondria, Liver; Nitrates; Oxidative Stress; Peroxynitrous Acid; Protein Subunits; Tyrosine

2011
Regulation of the ischemia-induced autophagy-lysosome processes by nitrosative stress in endothelial cells.
    Journal of pineal research, 2011, Volume: 51, Issue:1

    Topics: Animals; Autophagy; Brain; Brain Ischemia; Cell Line; Endothelial Cells; Glucose; Humans; Immunohistochemistry; Intracranial Embolism; Lysosomes; Male; Melatonin; Microscopy, Fluorescence; Microspheres; Microvessels; Nerve Tissue Proteins; Nitrosation; Oxygen; Peroxynitrous Acid; Rats; Rats, Wistar; Stress, Physiological

2011
Chemiluminometric evaluation of melatonin and selected melatonin precursors' interaction with reactive oxygen and nitrogen species.
    Analytical biochemistry, 2012, Jan-01, Volume: 420, Issue:1

    Topics: 5-Hydroxytryptophan; Automation, Laboratory; Chemistry Techniques, Analytical; Equipment Design; Free Radical Scavengers; Hydrogen Peroxide; Hydroxyl Radical; Luminescence; Luminol; Melatonin; Peroxynitrous Acid; Reactive Oxygen Species; Tryptophan

2012
Blunted epidermal L-tryptophan metabolism in vitiligo affects immune response and ROS scavenging by Fenton chemistry, part 1: Epidermal H2O2/ONOO(-)-mediated stress abrogates tryptophan hydroxylase and dopa decarboxylase activities, leading to low seroton
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2012, Volume: 26, Issue:6

    Topics: Adult; Calcium Channels, L-Type; Cells, Cultured; Dopa Decarboxylase; Epidermis; Humans; Hydrogen Peroxide; Melatonin; Middle Aged; Oxidation-Reduction; Peroxynitrous Acid; Reactive Oxygen Species; Serotonin; Tryptophan; Tryptophan Hydroxylase; Vitiligo

2012
Melatonin attenuates ovarian ischemia reperfusion injury in rats by decreasing oxidative stress index and peroxynitrite
    Turkish journal of medical sciences, 2020, 10-22, Volume: 50, Issue:6

    Topics: Animals; Female; Melatonin; Ovarian Torsion; Ovary; Oxidative Stress; Peroxynitrous Acid; Rats; Rats, Wistar; Reperfusion Injury

2020
Melatonin Attenuates Peroxynitrite-Induced Meiosis Dysfunction in Porcine Oocytes.
    Reproductive sciences (Thousand Oaks, Calif.), 2021, Volume: 28, Issue:5

    Topics: Animals; Female; Meiosis; Melatonin; Oocytes; Peroxynitrous Acid; Reactive Oxygen Species; Sus scrofa

2021