peroxynitrous acid has been researched along with linsidomine in 209 studies
| Studies (peroxynitrous acid) | Trials (peroxynitrous acid) | Recent Studies (post-2010) (peroxynitrous acid) | Studies (linsidomine) | Trials (linsidomine) | Recent Studies (post-2010) (linsidomine) |
|---|---|---|---|---|---|
| 3,303 | 21 | 1,230 | 1,441 | 35 | 94 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (0.96) | 18.2507 |
| 2000's | 165 (78.95) | 29.6817 |
| 2010's | 40 (19.14) | 24.3611 |
| 2020's | 2 (0.96) | 2.80 |
| Authors | Studies |
|---|---|
| Fink, MP; Menconi, MJ; Unno, N | 1 |
| Hiramoto, K; Kikugawa, K; Tomiyama, S | 1 |
| Kim, MS; Lee, HS; Lee, J; Lee, KM; Moon, BS; Park, R; So, HS | 1 |
| Dawson, R; Mehta, TR | 1 |
| Hewett, SJ; Trackey, JL; Uliasz, TF | 1 |
| Trakranrungsie, N; Will, JA | 1 |
| Brochet, B; Deloire-Grassin, MS; Petry, KG; Touil, T; Vital, C | 1 |
| Choi, CR; Choi, JW; Jang, ES; Ju, C; Kim, HC; Kim, WK; Ko, KH; Shin, CY | 1 |
| Choi, JW; Jang, ES; Kim, HC; Kim, WK; Ko, KH; Ryu, JH; Shin, CY | 1 |
| Khramtsov, VV; Sergeeva, SV; Slepneva, IA | 1 |
| Ahmed, Z; Connelly, PW; Draganov, D; Emili, A; Kuksis, A; La Du, BN; Maguire, GF; Ravandi, A | 1 |
| Cooke, CL; Davidge, ST | 1 |
| Kato, Y; Maruyama, W; Naoi, M; Sato, Y; Shamoto-Nagai, M; Tanaka, M; Yamamoto, T; Yi, H | 1 |
| de Groot, H; Kirsch, M | 1 |
| Daiber, A; Frein, D; Namgaladze, D; Ullrich, V | 1 |
| Mak, IT; Weglicki, WB; Zhang, J | 1 |
| Masuda, M; Nishino, H; Ohshima, H | 1 |
| Kamisaki, Y; Maeda, S; Saeki, M; Wada, K | 1 |
| Folkerts, G; Habernickel, J; Muijsers, RB; Nijkamp, FP; Postma, DS; van der Veeken, A | 1 |
| da Rocha, FA; de Brum-Fernandes, AJ | 1 |
| Hisatsune, T; Kaieda, I; Kaji, T; Kaminogawa, S | 1 |
| Li, CQ; Trudel, LJ; Wogan, GN | 1 |
| Azarov, VI; Harmatina, OIu; Moĭbenko, OO | 1 |
| Kamisaki, Y; Maeda, S; Saeki, M | 1 |
| Motohashi, N; Saito, Y | 1 |
| Hayakawa, A; Hayashi, S; Kobayashi, T; Liu, DG; Nagasaka, T; Nakao, A; Negita, M; Yokoyama, I | 1 |
| Cairo, G; Campanella, A; Minotti, G; Recalcati, S; Ronchi, R | 1 |
| Choi, CR; Choi, JW; Jang, ES; Kim, HC; Kim, WK; Ko, KH; Ryu, JR; Shin, CY | 1 |
| Cornish, AS; Jijon, H; Madsen, KL; Yachimec, C | 1 |
| Laude, K; Richard, V; Thuillez, C | 1 |
| Choi, JJ; Kim, HC; Kim, WK; Ko, KH; Kong, MY; Lee, SJ | 1 |
| Choi, JS; Chung, HY; Kim, AR; Kim, JE; Zou, Y | 1 |
| Haskew, RE; Kimelberg, HK; Mongin, AA | 1 |
| Freels, JL; Habib, M; Hoyt, JC; Lantz, RC; Nelson, DK; Numanami, H; Robbins, RA | 1 |
| Rosenberg, PA; Zhang, Y | 2 |
| Graier, WF; Groschner, K; Malli, R; Schmidt, K; Thyagarajan, B | 1 |
| Josephs, M; Katan, M; Rodrigues-Lima, F | 1 |
| Brimer, CM; Hooper, DC; Kean, RB; Koprowski, H; Mikheeva, T; Scott, GS; Spitsin, SV; Zborek, A | 1 |
| Bao, F; Liu, D | 2 |
| Choi, SH; Kang, KW; Kim, SG | 1 |
| Hooper, DC; Kean, RB; Koprowski, H; Mikheeva, T; Scott, GS; Spitsin, SV | 1 |
| Drapier, JC; Soum, E | 1 |
| Bao, F; DeWitt, DS; Liu, D; Prough, DS | 2 |
| Kil, IS; Kim, SY; Lee, JH; Park, JW; Yang, ES | 1 |
| Barnes, PJ; Donnelly, LE; Fenwick, PS; Jones, GE; Nabeyrat, E | 1 |
| Clements, MK; Hanson, AJ; Nelson-Overton, LK; Quinn, MT; Rohn, TT; Siemsen, DW; Swain, SD | 1 |
| Denicola, A; Radi, R; Thomson, L | 1 |
| Fukuda, S; Takakura, K; Takeuchi, K; Xiaohong, W; Yasuda, Y | 1 |
| McConnell, P; Reasor, MJ; Van Dyke, K | 1 |
| Buoncristiani, U; Canestrari, F; Davenport, A; Ferraro, B; Frei, B; Galli, F; Kingdon, E; Moore, KP; Rice-Evans, C | 1 |
| Aoyagi, K; Cho, EJ; Rhyu, DY; Yokozawa, T | 1 |
| Bai, P; Bakondi, E; Csernoch, L; Gergely, P; Gönczi, M; Hunyadi, J; Kovács, L; Pacher, P; Szabó, C; Szabó, E; Virág, L | 1 |
| Frangos, JA; McKittrick, J; Muyco, J; Suzuki, R | 1 |
| Acosta, F; Díaz, R; Ellis, AE; Padilla, D; Real, F; Ruiz de Galarreta, CM | 1 |
| Akhter, S; Green, JR; Mutus, B; Root, P; Thatcher, GJ | 1 |
| Alloatti, G; Bedendi, I; Gallo, MP; Levi, RC; Malan, D; Marcantoni, A | 1 |
| He, BP; Sopper, M; Strong, M | 1 |
| Aldini, G; Carini, M; Facino, RM; Piccoli, A; Rossoni, G | 1 |
| Buhler, DR; Frei, B; Miranda, CL; Stevens, JF | 1 |
| Fukuda, S; Takakura, K; Takeuchi, K; Xiaohong, W | 1 |
| Atmane, N; Dairou, J; Dupret, JM; Rodrigues-Lima, F | 1 |
| Cobbs, CS; Harkins, LE; Samanta, M; Van Meir, EG; Wesemann, DR; Whisenhunt, TR | 1 |
| Giuntini, J; Giusti, L; Lucacchini, A; Mazzoni, MR | 1 |
| Hisatomi, T; Ishibashi, T; Ito, S; Kimoto, T; Rao, NA; Wu, GS | 1 |
| Hiramoto, K; Kikugawa, K; Ohkawa, T | 1 |
| Deeb, RS; Gamss, C; Hajjar, DP; Lindenbaum, R; Mittar, D; Resnick, MJ; Upmacis, RK | 1 |
| Ohshima, H; Saleem, M | 1 |
| Chen, L; Fuller, CM; Kleyman, TR; Matalon, S | 1 |
| Crow, JP; Nielsen, VG | 1 |
| Maleque, MA; Motley, ED; Richardson, SM | 1 |
| Cao, Z; Li, Y | 2 |
| Crow, JP; Nielsen, VG; Parks, DA; Zhou, F | 1 |
| Kimelberg, HK | 1 |
| Arai, H; Nakamura, K | 1 |
| Choi, JB; Igarashi, Y; Kashiwagi, A; Kawamori, R; Maegawa, H; Mineki, R; Murayama, K; Nomiyama, T; Ogihara, T; Taka, H; Tanaka, Y; Uchida, T; Uchino, H; Watada, H | 1 |
| Arai, T; Maruyama, K; Ohuchi, T; Shibata, Y; Sugawara, F; Yoshida, K | 1 |
| Crow, JP; Mogal, A; Nielsen, VG; Parks, DA; Zhou, F | 1 |
| Dal Rio, FP; Haslett, C; Megson, IL; Rossi, AG; Shaw, CA; Taylor, EL | 1 |
| Chan, SH; Hsu, KS; Huang, CC | 1 |
| Donohue, TM; Haorah, J; Krutik, VM; Osna, NA | 1 |
| Kim, SG; Kim, SO | 1 |
| Dikalov, S; Greilberger, J; Oettl, K; Reibnegger, G | 1 |
| Muyderman, H; Nilsson, M; Sims, NR | 1 |
| Huang, XL; Pan, BX; Zhao, GL; Zhao, KS | 1 |
| Han, BH; Ju, C; Kim, HC; Kim, HS; Kim, WK; Oh, YJ | 1 |
| Gu, Y; Lewis, DF; Wang, Y; Zhang, Y; Zhao, S | 1 |
| Camargo, C; López-Alarcón, C; Núñez-Vergara, LJ; Olea-Azar, C; Speisky, H; Squella, JA | 1 |
| Aizenman, E; Jimenez, DA; Levitan, ES; Li, J; Rosenberg, PA; Wang, H; Zhang, Y | 1 |
| Acquaviva, R; Avola, R; Barcellona, ML; Campisi, A; Li Volti, G; Mangiameli, S; Murabito, P; Musumeci, I; Raciti, G; Vanella, A | 1 |
| Gutiérrez-Martin, Y; Gutiérrez-Merino, C; Henao, F; Martin-Romero, FJ | 2 |
| Adapala, NS; Chan, MM; Fong, D | 1 |
| Cho, EJ; Ikeshiro, Y; Kashiwada, Y; Satoh, A; Yokozawa, T | 1 |
| Bachschmid, M; Schildknecht, S; Ullrich, V | 1 |
| Brugnara, C; De Franceschi, L; Di Stasi, AM; Mallozzi, C | 1 |
| Abiru, S; Eguchi, K; Ishibashi, H; Komori, A; Maeda, Y; Migita, K; Nakamura, M; Takii, Y; Yatsuhashi, H; Yokoyama, T | 1 |
| Dairou, J; Dupret, JM; Rodrigues-Lima, F | 1 |
| Choi, JW; Choi, MS; Ko, KH; Park, GH; Ryu, MK; Yoo, BK | 1 |
| Choi, JW; Choi, MS; Jeon, MJ; Ko, KH; Park, GH; Ryu, MK; Yoo, oK | 1 |
| Acquaviva, R; Avola, R; Barcellona, ML; Campisi, A; Li Volti, G; Raciti, G; Vanella, L | 1 |
| Desole, MS; Esposito, G; Marchetti, B; Miele, E; Migheli, R; Mura, MP; Rocchitta, G; Serra, PA | 1 |
| Austin, RC; Dickhout, JG; Hossain, GS; Lhoták, S; Pozza, LM; Zhou, J | 1 |
| Clemens, DL; Donohue, TM; Osna, NA | 1 |
| Bramey, T; De Groot, H; Kirsch, M; Petrat, F | 1 |
| Alexander, JS; Gu, Y; Lewis, DF; Wang, Y; Zhang, Y; Zhao, S | 1 |
| Barbar, EJ; Deeb, RS; Gross, SS; Hajjar, DP; Hao, G; Lainé, M; Qiu, JH; Resnick, B; Upmacis, RK | 1 |
| Hader, W; Yang, C; Zhang, X | 1 |
| Aureliano, M; Gutiérrez-Merino, C; Ramos, S; Tiago, T | 1 |
| Cherenkevich, SN; Kulahava, TA; Kvacheva, ZB; Semenkova, GN; Timoshenko, AV | 1 |
| Cheng, ML; Chiu, DT; Ho, HY; Wei, TT | 1 |
| Aureliano, M; Gutiérrez-Merino, C; Martín-Romero, FJ; Simão, S; Tiago, T | 1 |
| Doke, N; Kawakita, K; Saito, S; Yamamoto-Katou, A; Yoshioka, H | 1 |
| Moon, HK; Park, JW; Yang, ES | 1 |
| Cha, YN; Li, MH; Surh, YJ | 2 |
| El Bohi, K; Fujita, S; Ishizuka, M; Kazusaka, A; Muzandu, K; Sakamoto, KQ; Shaban, Z | 1 |
| Bar-Shai, M; Reznick, AZ | 1 |
| Pollard, SE; Spencer, JP; Whiteman, M | 1 |
| Christopher, TA; Coletti, C; Gao, E; Hu, A; Koch, W; Lopez, BL; Ma, XL; Tao, L; Wang, Y | 1 |
| Akerström, S; Falk, KI; Hardestam, J; Klingström, J; Lundkvist, A; Mirazimi, A; Rottenberg, M; Simon, M; Stoltz, M | 1 |
| Christopher, T; Gao, E; Jiao, X; Koch, W; Lau, WB; Lopez, B; Ma, XL; RamachandraRao, SP; Sharma, K; Southan, G; Tao, L; Williams, W; Yuan, Y | 1 |
| Bar-Shai, M; Hasnis, E; Reznick, AZ; Wiener-Megnazi, Z | 1 |
| Arundine, M; Jones, M; Lau, A; Sun, HS; Tymianski, M | 1 |
| Hegde, KR; Varma, SD | 1 |
| Carbonneau, MA; Fouret, G; Leger, CL; Torres-Rasgado, E | 1 |
| Angelos, MG; Aune, SE; Falk, JA; Kuppusamy, P; Kutala, VK | 1 |
| Hall, ED; Singh, IN; Sullivan, PG | 1 |
| Cha, YN; Jang, JH; Li, MH; Na, HK; Surh, YJ | 1 |
| Dairou, J; Dupret, JM; Haddad, I; Mary, J; Noiran, J; Petit, E; Pluvinage, B; Rodrigues-Lima, F; Vinh, J | 1 |
| Jin, S; Kawanokuchi, J; Mizuno, T; Sonobe, Y; Suzumura, A; Takeuchi, H; Wang, J | 1 |
| Delaney, JC; Delaney, S; Essigmann, JM | 1 |
| Aoki, T; Arai, T; Kamisuki, S; Kimoto, K; Kobayashi, S; Kuramochi, K; Kuroiwa, K; Nakazaki, A; Shibata, Y; Sugawara, F; Watanabe, N | 1 |
| Black, SA; Ferguson, SS; Pholpramool, C; Pinthong, M; Ribeiro, FM; Rylett, RJ | 1 |
| Lei, T; Liu, ZW; Yang, Z; Zhang, T | 1 |
| Kohr, MJ; Velayutham, M; Wang, H; Wheeler, DG; Ziolo, MT; Zweier, JL | 1 |
| Burdo, J; Maher, P; Schubert, D | 1 |
| Beconi, MT; Rodriguez, PC | 1 |
| Cui, J; Jang, MH; Piao, X; Piao, XL | 1 |
| Cho, EJ; Jang, MH; Piao, XL | 1 |
| Davies, MJ; Kennett, EC | 1 |
| Cepinskas, G; Inculet, R; Mehta, S; Shelton, JL; Wang, L | 1 |
| Ashki, N; Bao, F; Hayes, KC | 1 |
| Kang, KS; Park, JC; Rhyu, DY; Sekiya, M; Tanaka, T; Yokozawa, T | 1 |
| Asatryan, L; Gallaher, TK; Hamilton, RT; Hsiai, TK; Isas, JM; Nilsen, JT; Sawamura, T | 1 |
| Klassen, SS; Rabkin, SW | 1 |
| Akamatsu, K; Furukawa, K; Hayata, A; Hirano, T; Ichikawa, T; Ichinose, M; Kanda, M; Koarai, A; Matsunaga, K; Minakata, Y; Nakanishi, M; Sugiura, H; Yanagisawa, S | 1 |
| Aoki, K; Kato, S; Saso, N; Sato, H; Sugiyama, Y | 1 |
| Aldinucci, C; Blanco Garcia, J; Buonocore, G; Maiorca, SM; Palmi, M; Pessina, GP; Valoti, M | 1 |
| Hotter, G; Jung, M; Sola, A; Viñas, JL | 1 |
| Arai, T; Fujieda, S; Kobayashi, S; Kuramochi, K; Nakajima, M; Nakazaki, A; Ohnishi, K; Saitoh, Y; Sugawara, F; Takeuchi, T; Watanabe, N | 1 |
| Jia, Z; Li, Y; Misra, BR; Misra, HP; Vitto, MJ; Zhu, H | 1 |
| Belaaouaj, A; Crouch, EC; Gao, Z; Kirk, M; Matalon, S; McDonald, B; Shrestha, K; Smith, K; Waldheuser, S | 1 |
| Arai, T; Konishi, K; Watanabe, N | 1 |
| Cubero, FJ; Nieto, N; Urtasun, R; Vera, M | 1 |
| Cho, EJ; Cui, J; Jang, MH; Piao, XL | 1 |
| Boos, N; Hottiger, M; Poveda, L; Wuertz, K | 1 |
| Bachschmid, MM; Daiber, A; Kamuf, J; Müller, J; Schildknecht, S; Ullrich, V | 1 |
| Hall, ED; Singh, IN; Xiong, Y | 1 |
| Huang, K; Zhou, J | 1 |
| Davidge, ST; Sankaralingam, S; Xu, H | 1 |
| Barbosa-Sicard, E; Brandes, RP; Braun, T; Fleming, I; Frömel, T; Hammock, BD; Keserü, B; Krüger, M; Morisseau, C | 1 |
| Chen, W; Jia, Z; Li, Y; Misra, HP; Zhou, K; Zhu, H | 1 |
| Chen, W; Jia, Z; Li, J; Li, Y; Misra, HP; Zhou, K; Zhu, H | 1 |
| Antunes, E; Cardoso, MH; De Nucci, G; Lilla, S; Marcondes, S; Morganti, RP; Murad, F | 1 |
| Gao, X; Kadowitz, PJ; Murthy, SN; Raghavamenon, AC; Sathishkumar, K; Uppu, RM | 1 |
| Lodhia, P; Luong, MW; Rabkin, SW | 1 |
| Jia, Z; Li, Y; Misra, HP; Zhu, H | 1 |
| Burns, ST; Doerge, DR; Hinson, JA; Holthoff, JH; Mayeux, PR; Woodling, KA | 1 |
| Domingo de Miguel, E; Iraburu, MJ; López-Zabalza, MJ; Mòdol, T; Natal, C; Pérez de Obanos, MP | 1 |
| Chen, CC; Hsu, YJ; Lee, TM | 1 |
| Delledonne, M; Gaupels, F; Spiazzi-Vandelle, E; Yang, D | 1 |
| Aggarwal, S; Black, SM; Datar, S; Fineman, JR; Fratz, S; Gross, CM; Kalkan, G; Kumar, S; Oishi, P; Schreiber, C | 1 |
| Aureliano, M; Gutierrez-Merino, C; Marques-da-Silva, D; Samhan-Arias, AK; Tiago, T | 1 |
| Fujimoto, S; Higashi, Y; Nagasawa, K; Nishida, K; Nishiura, T; Okuda, H; Tanaka, A | 1 |
| Beaugé, L; DiPolo, R | 1 |
| Andersson, B; Andersson, H; Golovliov, I; Lindgren, H; Sjöstedt, A; Tancred, L; Telepnev, MV | 1 |
| Lai, R; Li, S; Lin, W; Tchantchou, F; Wen, J; Zhang, Y | 1 |
| Dhammu, TS; Gilg, AG; Im, YB; Khan, M; Sakakima, H; Shunmugavel, A; Singh, AK; Singh, I | 1 |
| Chen, W; Han, Q; Li, A; Li, J; Li, Y; Ye, L | 1 |
| Agbani, E; Coats, P; Wadsworth, RM | 1 |
| Altiok, S; Celis, E; Cheng, P; Gabrilovich, D; Lu, T; Pisarev, V; Ramakrishnan, R; Sherman, S; Sporn, MB; Youn, JI | 1 |
| Arnould, T; Boudjeltia, KZ; Caesens-Koenig, L; Calay, D; Mattart, L; Michiels, C; Raes, M; Roebroeck, L; Roebroek, L; Simon, D; Tevel, V; Van Steenbrugge, M | 1 |
| Barcikowska, M; Buizza, L; Buoso, E; Butterfield, DA; Cenini, G; Ferrari-Toninelli, G; Govoni, S; Lanni, C; Memo, M; Prandelli, C; Racchi, M; Styczynska, M; Szybinska, A; Uberti, D | 1 |
| Markowicz Bastos, DH; Matsumoto, RLT; Mendonça, S; Moura de Oliveira, D; Souza, MF | 1 |
| Chung, HT; Kim, KM; Park, YC; Song, JD | 1 |
| Badejo, AM; Bhartiya, M; Bueno, FR; Casey, DB; Kadowitz, PJ; Murthy, SN; Nossaman, BD; Pankey, EA; Uppu, RM | 1 |
| Carail, M; Caris-Veyrat, C; Graham, DL; Lowe, GM | 1 |
| Black, SA; Cuddy, LK; Ferguson, SS; Gordon, AC; Jaworski, E; Rylett, RJ | 1 |
| Kim, H; Kim, YA; Kong, CS; Lee, C; Lee, HS; Lee, JI; Park, HY; Seo, Y | 1 |
| Adak, S; Bose, M; Mukherjee, S; Roy, J; Saha, R; Sen Santara, S | 1 |
| Bédiar-Boulaneb, F; Belguendouz, H; Hartani, D; Lahlou-Boukoffa, OS; Lahmar-Belguendouz, K; Touil-Boukoffa, C | 1 |
| Hemanth Kumar, K; Khanum, F; Pal, A; Tamatam, A | 1 |
| Calcerrada, P; Cassina, A; de Bem, AF; Fiuza, B; Peluffo, G; Piacenza, L; Radi, R; Rocha, JB; Straliotto, MR; Subelzú, N | 1 |
| Boguen, R; Sánchez, R; Treulen, F; Uribe, P; Villegas, JV | 2 |
| Akbarali, HI; Gade, A; Hashimoto, A; Kang, M | 1 |
| Arnhold, J; Flemmig, J; Koyani, CN; Malle, E | 1 |
| Álvarez, J; Cabrillana, ME; Fornés, MW; Sánchez, R; Uribe, P; Villegas, JV | 1 |
| Gao, W; Gao, Z; Li, H; Zhao, J | 1 |
| Chakraborty, S; Datta, S; Ghosh, S; Panja, C | 1 |
| Chew, CY; Chung, TH; Lam, CH; Tan, KT; Wu, YP | 1 |
| Lanner, JT; Persson, M; Rassier, DE; Steinz, MM; Westerblad, H | 1 |
| Escalante, B; Flores-Tamez, V; Rios, A | 1 |
| Alvarsson, M; Mahdi, A; Pernow, J; Tengbom, J; Wernly, B; Zhou, Z | 1 |
| Albuck, AL; Evans, WR; Katakam, PVG; Kolli, L; Mostany, R; Sakamuri, SSVP; Sperling, JA; Sure, VN | 1 |
209 other study(ies) available for peroxynitrous acid and linsidomine
| Article | Year |
|---|---|
Nitric oxide-induced hyperpermeability of human intestinal epithelial monolayers is augmented by inhibition of the amiloride-sensitive Na(+)-H+ antiport: potential role of peroxynitrous acid.
Topics: Amiloride; Cell Membrane Permeability; Colonic Neoplasms; Deferoxamine; Humans; Intestinal Mucosa; Membrane Potentials; Molsidomine; Nitrates; Nitric Oxide; Nitrous Acid; Peroxynitrous Acid; Sodium-Hydrogen Exchangers; Superoxides; Tumor Cells, Cultured | 1997 |
Effective inhibition by beta-carotene of cellular DNA breaking induced by peroxynitrous acid.
Topics: Antioxidants; Ascorbic Acid; beta Carotene; Chromans; Dimethyl Sulfoxide; DNA; DNA Damage; Dose-Response Relationship, Drug; Electrophoresis, Agar Gel; Free Radical Scavengers; Furans; HL-60 Cells; Humans; Mannitol; Microscopy, Fluorescence; Molsidomine; Nitrous Acid; Peroxynitrous Acid; Solubility; Sorbic Acid; Time Factors | 1999 |
Danchunhwan water extract prevents apoptotic death by peroxynitrite and nitric oxide in human dopaminergic neuroblastoma SH-SY5Y cells.
Topics: Antioxidants; Apoptosis; Caspase 3; Caspases; Dopamine; Drug Interactions; Drugs, Chinese Herbal; Glutathione; Humans; Molsidomine; Neuroblastoma; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Oxidative Stress; Peroxynitrous Acid; Phytotherapy; Plant Extracts; Salvia miltiorrhiza; Tumor Cells, Cultured | 2001 |
Taurine is a weak scavenger of peroxynitrite and does not attenuate sodium nitroprusside toxicity to cells in culture.
Topics: Animals; Cell Death; Cell Division; Cell Survival; Dose-Response Relationship, Drug; Free Radical Scavengers; Free Radicals; Molsidomine; Nitric Oxide Donors; Nitroprusside; PC12 Cells; Peroxynitrous Acid; Rats; Rhodamines; Taurine; Time Factors | 2001 |
SIN-1-induced cytotoxicity in mixed cortical cell culture: peroxynitrite-dependent and -independent induction of excitotoxic cell death.
Topics: Animals; Astrocytes; Catalase; Cell Death; Cells, Cultured; Cerebral Cortex; Free Radical Scavengers; Mice; Molsidomine; Neurons; Neurotoxins; Peroxynitrous Acid; Superoxide Dismutase; Tyrosine | 2001 |
Comparative vasodilation of peroxynitrite and 3-morpholinosydnonimine.
Topics: Adenine; Animals; Benzoates; Cattle; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Enzyme Inhibitors; Female; Guanylate Cyclase; Imidazoles; In Vitro Techniques; Mammary Arteries; Molsidomine; Muscle Relaxation; Muscle, Smooth, Vascular; Oxadiazoles; Oxazines; Oxidants; Peroxynitrous Acid; Vasodilation; Vasodilator Agents | 2001 |
In vivo damage of CNS myelin and axons induced by peroxynitrite.
Topics: Animals; Axons; Central Nervous System; Male; Molsidomine; Myelin Sheath; Nitric Oxide Donors; Peroxynitrous Acid; Rats; Rats, Wistar | 2001 |
Dehydroepiandrosterone inhibits the death of immunostimulated rat C6 glioma cells deprived of glucose.
Topics: Adjuvants, Immunologic; Animals; Astrocytes; Brain; Brain Ischemia; Cell Death; Cytokines; Dehydroepiandrosterone; Enzyme Inhibitors; Free Radical Scavengers; Glioma; Glucose; Herbicides; Humans; Interferon-gamma; Lipopolysaccharides; Metalloporphyrins; Molsidomine; Neurons; Nitric Oxide; Oxidative Stress; Paraquat; Peroxynitrous Acid; Superoxide Dismutase; Tumor Cells, Cultured; Tyrosine | 2001 |
Glucocorticoids exacerbate peroxynitrite mediated potentiation of glucose deprivation-induced death of rat primary astrocytes.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Astrocytes; Cell Death; Cells, Cultured; Dexamethasone; Glucocorticoids; Glucose; Hormone Antagonists; Interferon-gamma; Membrane Potentials; Mifepristone; Mitochondria; Molsidomine; Nitric Oxide Donors; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley | 2001 |
Effect of selenolipoic acid on peroxynitrite-dependent inactivation of NADPH-cytochrome P450 reductase.
Topics: Animals; Enzyme Inhibitors; Free Radical Scavengers; In Vitro Techniques; Kinetics; Microsomes, Liver; Molsidomine; NADP; NADPH-Ferrihemoprotein Reductase; Nitric Oxide Donors; Peroxynitrous Acid; Rats; Sulfhydryl Compounds; Thioctic Acid | 2001 |
Multiple substrates for paraoxonase-1 during oxidation of phosphatidylcholine by peroxynitrite.
Topics: Aryldialkylphosphatase; Enzyme Inhibitors; Esterases; Humans; Hydrolysis; Lipoproteins; Models, Chemical; Molsidomine; Oxygen; Peroxynitrous Acid; Phosphatidylcholines; Phosphatidylethanolamines; Protein Binding; Proteolipids; Spectrometry, Mass, Electrospray Ionization; Substrate Specificity; Time Factors | 2002 |
Peroxynitrite increases iNOS through NF-kappaB and decreases prostacyclin synthase in endothelial cells.
Topics: Animals; Cattle; Cells, Cultured; Cyclooxygenase 2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Endothelium, Vascular; Intramolecular Oxidoreductases; Isoenzymes; Molsidomine; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Prostaglandin-Endoperoxide Synthases | 2002 |
Selective nitration of mitochondrial complex I by peroxynitrite: involvement in mitochondria dysfunction and cell death of dopaminergic SH-SY5Y cells.
Topics: Adenosine Triphosphate; Apoptosis; Cell Death; Cysteine Proteinase Inhibitors; Dopamine; Electron Transport Complex I; Humans; Mitochondria; Molsidomine; NADH, NADPH Oxidoreductases; Nitric Oxide Donors; Oligopeptides; Peroxynitrous Acid; Subcellular Fractions; Tumor Cells, Cultured; Tyrosine | 2002 |
Formation of peroxynitrite from reaction of nitroxyl anion with molecular oxygen.
Topics: Animals; Anions; Antioxidants; Cattle; Dose-Response Relationship, Drug; Hydrogen Peroxide; Hydrogen-Ion Concentration; Models, Chemical; Molsidomine; NAD; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitrites; Nitrogen Oxides; Oxygen; Peroxynitrous Acid; Rhodamines; Superoxide Dismutase | 2002 |
Oxidation and nitrosation in the nitrogen monoxide/superoxide system.
Topics: Animals; Biochemical Phenomena; Biochemistry; Cattle; Chelating Agents; Chromatography, High Pressure Liquid; Chromogenic Compounds; Disulfides; Dose-Response Relationship, Drug; Free Radicals; Hydrazines; Hydrogen Peroxide; Models, Chemical; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitrogen; Nitrogen Oxides; Oxygen; Peroxynitrous Acid; Protein Binding; Resorcinols; Spectrophotometry; Spectrum Analysis, Raman; Spermine; Sulfhydryl Compounds; Superoxides; Time Factors; Ultraviolet Rays; Xanthine Oxidase; Zinc | 2002 |
Protective effects of dihydropyridine Ca-blockers against endothelial cell oxidative injury due to combined nitric oxide and superoxide.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Cattle; Cell Survival; Cells, Cultured; Chromans; Dose-Response Relationship, Drug; Endothelium, Vascular; Glutathione; Lipid Peroxidation; Molsidomine; Nicardipine; Nifedipine; Nisoldipine; Nitric Oxide; Oxidative Stress; Peroxynitrous Acid; Superoxides; Thiobarbituric Acid Reactive Substances | 2002 |
Formation of 8-nitroguanosine in cellular RNA as a biomarker of exposure to reactive nitrogen species.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Biomarkers; Carcinoma; Cattle; Deoxyguanosine; Guanine; Humans; Lung Neoplasms; Molsidomine; Peroxynitrous Acid; RNA, Neoplasm; Tumor Cells, Cultured | 2002 |
Insulin-like growth factor-1 protects peroxynitrite-induced cell death by preventing cytochrome c-induced caspase-3 activation.
Topics: Apoptosis; Caspase 3; Caspases; Cytochrome c Group; Dopamine; Drug Interactions; Enzyme Activation; Humans; Insulin-Like Growth Factor I; Molsidomine; Peroxynitrous Acid; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-bcl-2; Tumor Cells, Cultured | 2002 |
Intra-luminal exposure of murine airways to peroxynitrite causes inflammation but not hyperresponsiveness.
Topics: Acetylcholine; Animals; Bronchi; Bronchial Hyperreactivity; Inflammation; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Molsidomine; Peroxynitrous Acid; Trachea; Tyrosine | 2002 |
Evidence that peroxynitrite affects human osteoblast proliferation and differentiation.
Topics: Alkaline Phosphatase; Catalase; Cell Differentiation; Cell Division; Cells, Cultured; Humans; Interferon-gamma; Interleukin-1; Molsidomine; Nitric Oxide Donors; Nitrites; Osteoblasts; Peroxynitrous Acid; Recombinant Proteins; Superoxide Dismutase; Thymidine; Tumor Necrosis Factor-alpha; Tyrosine | 2002 |
3-Morpholinosydnonimine hydrochloride induces p53-dependent apoptosis in murine primary neural cells: a critical role for p21(ras)-MAPK-p19(ARF) pathway.
Topics: Animals; Apoptosis; Cyclin-Dependent Kinase Inhibitor p16; Mice; Mice, Inbred ICR; Mitogen-Activated Protein Kinases; Molsidomine; Neurons; Nitric Oxide Donors; Peroxynitrous Acid; Proto-Oncogene Proteins p21(ras); Signal Transduction; Tumor Suppressor Protein p14ARF; Tumor Suppressor Protein p53 | 2002 |
Genotoxicity, mitochondrial damage, and apoptosis in human lymphoblastoid cells exposed to peroxynitrite generated from SIN-1.
Topics: Apoptosis; Cell Survival; Cells, Cultured; Comet Assay; DNA; DNA Damage; Drug Antagonism; Free Radical Scavengers; Humans; Hypoxanthine Phosphoribosyltransferase; Lymphocytes; Mitochondria; Molsidomine; Mutagens; Peroxynitrous Acid; Thymidine Kinase; Vasodilator Agents | 2002 |
[Effects of nitric oxide donor SIN-1 on calcium transport in rat cardiac sarcoplasmic reticulum].
Topics: Animals; Calcium; Calcium Channels; Ion Transport; Molsidomine; Myocardium; Nitric Oxide; Nitric Oxide Donors; Peroxynitrous Acid; Rats; Sarcoplasmic Reticulum; Superoxides | 2001 |
Vanadate protects human neuroblastoma SH-SY5Y cells against peroxynitrite-induced cell death.
Topics: Cell Death; Crk-Associated Substrate Protein; Cyclosporine; Enzyme Inhibitors; Humans; Molsidomine; Neuroblastoma; Nitric Oxide Donors; Okadaic Acid; Peroxynitrous Acid; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Protein Tyrosine Phosphatases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-crk; Retinoblastoma-Like Protein p130; Signal Transduction; Tumor Cells, Cultured; Vanadates | 2002 |
Induction of SOS response in Salmonella typhimurium TA4107/pSK1002 by peroxynitrite-generating agent, N-morpholino sydnonimine.
Topics: Kinetics; Molsidomine; Oxidative Stress; Peroxynitrous Acid; Plasmids; Salmonella typhimurium; SOS Response, Genetics | 2002 |
Prevention of free-radical induced apoptosis by induction of human recombinant Cu, Zn-SOD in pig endothelial cells.
Topics: Animals; Apoptosis; Endothelium, Vascular; Free Radicals; Humans; Molsidomine; Nitric Oxide Donors; Peroxynitrous Acid; Reactive Oxygen Species; Superoxide Dismutase; Swine; Transplantation, Heterologous | 2002 |
Nitric oxide and peroxynitrite activate the iron regulatory protein-1 of J774A.1 macrophages by direct disassembly of the Fe-S cluster of cytoplasmic aconitase.
Topics: Aconitate Hydratase; Animals; Cell Line; Cell-Free System; Cytoplasm; Escherichia coli; Ferrous Compounds; Ferrozine; Iron Regulatory Protein 1; Iron Regulatory Protein 2; Iron-Regulatory Proteins; Iron-Sulfur Proteins; Macrophages; Mice; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Peroxynitrous Acid; Protein Processing, Post-Translational; Recombinant Proteins; RNA-Binding Proteins; Superoxides | 2002 |
Adenosine and purine nucleosides protect rat primary astrocytes from peroxynitrite-potentiated, glucose deprivation-induced death: preservation of intracellular ATP level.
Topics: Adenosine; Adenosine Triphosphate; Animals; Astrocytes; Cell Death; Cells, Cultured; Dose-Response Relationship, Drug; Drug Synergism; Glioma; Glucose; Intracellular Fluid; L-Lactate Dehydrogenase; Molsidomine; Nitric Oxide Donors; Peroxynitrous Acid; Purine Nucleosides; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley | 2002 |
Peroxynitrite enhances the ability of Salmonella dublin to invade T84 monolayers.
Topics: Cell Division; Cells, Cultured; Enzyme Inhibitors; Epithelial Cells; Humans; Intestines; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitrogen; Nitrogen Oxides; omega-N-Methylarginine; Peroxynitrous Acid; Salmonella; Salmonella typhimurium; Spermine | 2002 |
Peroxynitrite triggers a delayed resistance of coronary endothelial cells against ischemia-reperfusion injury.
Topics: Acetylcholine; Animals; Coronary Vessels; Endothelium, Vascular; Enzyme Inhibitors; Free Radical Scavengers; Free Radicals; Ischemic Preconditioning, Myocardial; Male; Methionine; Molsidomine; Myocardial Reperfusion Injury; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Penicillamine; Peroxynitrous Acid; Rats; Rats, Wistar; Selenomethionine; Uric Acid | 2002 |
Ciclopirox prevents peroxynitrite toxicity in astrocytes by maintaining their mitochondrial function: a novel mechanism for cytoprotection by ciclopirox.
Topics: Adenosine Triphosphate; Animals; Astrocytes; Cell Cycle; Cell Death; Cells, Cultured; Ciclopirox; Flow Cytometry; Glutathione; Hydrogen Peroxide; Hydroxyl Radical; L-Lactate Dehydrogenase; Membrane Potentials; Mitochondria; Molsidomine; Neuroprotective Agents; Nitric Oxide; Oxidation-Reduction; Peroxynitrous Acid; Pyridones; Rats; Rats, Sprague-Dawley; Rhodamines; Serum Albumin, Bovine; Superoxides; Tyrosine | 2002 |
Peroxynitrite scavenging activity of sinapic acid (3,5-dimethoxy-4-hydroxycinnamic acid) isolated from Brassica juncea.
Topics: Brassica; Coumaric Acids; Free Radical Scavengers; Lipid Peroxidation; Lipoproteins, LDL; Molsidomine; Nitrates; Nitric Oxide; Oxidation-Reduction; Peroxynitrous Acid; Serum Albumin, Bovine; Superoxides; Tyrosine | 2002 |
Peroxynitrite enhances astrocytic volume-sensitive excitatory amino acid release via a src tyrosine kinase-dependent mechanism.
Topics: Adenosine Triphosphate; Animals; Astrocytes; Cell Size; Cells, Cultured; Enzyme Inhibitors; Excitatory Amino Acids; Intracellular Fluid; Ion Channels; Molsidomine; Nitric Oxide Donors; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; src-Family Kinases; Superoxide Dismutase | 2002 |
Enhanced activity of human IL-10 after nitration in reducing human IL-1 production by stimulated peripheral blood mononuclear cells.
Topics: Adjuvants, Immunologic; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Deferoxamine; Dithiothreitol; Down-Regulation; Humans; Hydrogen Peroxide; Interleukin-1; Interleukin-10; Leukocytes, Mononuclear; Molsidomine; Peroxynitrous Acid; Reducing Agents | 2002 |
The essential nutrient pyrroloquinoline quinone may act as a neuroprotectant by suppressing peroxynitrite formation.
Topics: Animals; Brain; Cell Survival; Dose-Response Relationship, Drug; Fetus; Molsidomine; Neurons; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Donors; Oxidative Stress; Peroxynitrous Acid; PQQ Cofactor; Quinolones; Quinones; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Stroke; Superoxides | 2002 |
Nitric oxide inhibits capacitative Ca2+ entry by suppression of mitochondrial Ca2+ handling.
Topics: Barium; Calcium; Cell Line; Cyclic GMP; Diethylamines; Dose-Response Relationship, Drug; Humans; Intracellular Membranes; Membrane Potentials; Mitochondria; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; Oxadiazoles; Oxygen Consumption; Peroxynitrous Acid; Quinoxalines; Thapsigargin; Time Factors | 2002 |
Irreversible inactivation of magnesium-dependent neutral sphingomyelinase 1 (NSM1) by peroxynitrite, a nitric oxide-derived oxidant.
Topics: Animals; Cysteine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hydrogen Peroxide; Magnesium; Mice; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Oxidants; Oxidative Stress; Peroxynitrous Acid; Reducing Agents; Sphingomyelin Phosphodiesterase | 2002 |
Comparison of uric acid and ascorbic acid in protection against EAE.
Topics: Albumins; Animals; Antioxidants; Ascorbic Acid; Blood-Brain Barrier; Cell Line; Encephalomyelitis, Autoimmune, Experimental; Free Radicals; Immunohistochemistry; Iron; Lipid Peroxidation; Mice; Molsidomine; Myelin Sheath; Nitric Oxide; Oxygen; Peroxynitrous Acid; Rhodamines; Time Factors; Tyrosine; Uric Acid | 2002 |
Peroxynitrite generated in the rat spinal cord induces neuron death and neurological deficits.
Topics: Animals; Cell Death; Dyskinesia, Drug-Induced; Male; Microdialysis; Molsidomine; Nerve Degeneration; Neurons; Nitric Oxide Donors; Oxidative Stress; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Cord Injuries | 2002 |
Peroxynitrite activates NF-E2-related factor 2/antioxidant response element through the pathway of phosphatidylinositol 3-kinase: the role of nitric oxide synthase in rat glutathione S-transferase A2 induction.
Topics: Amino Acids, Sulfur; Animals; Antioxidants; Cell Nucleus; Cytosol; DNA-Binding Proteins; Enzyme Induction; Glutathione Transferase; Liver Neoplasms, Experimental; Molsidomine; NF-E2-Related Factor 2; Nitric Oxide Synthase; Oxidative Stress; Peroxynitrous Acid; Phosphatidylinositol 3-Kinases; Rats; Response Elements; RNA, Messenger; S-Nitroso-N-Acetylpenicillamine; Trans-Activators; Tumor Cells, Cultured | 2002 |
Therapeutic intervention in experimental allergic encephalomyelitis by administration of uric acid precursors.
Topics: Administration, Oral; Animals; Biotransformation; Chromatography, High Pressure Liquid; Drug Evaluation, Preclinical; Encephalomyelitis, Autoimmune, Experimental; Enzyme Induction; Enzyme Inhibitors; Female; Humans; Inosine; Inosine Monophosphate; Mice; Molsidomine; Monocytes; Multiple Sclerosis; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidation-Reduction; Oxidative Stress; Oxonic Acid; Peroxynitrous Acid; Urate Oxidase; Uric Acid; Xanthines | 2002 |
Nitric oxide and peroxynitrite promote complete disruption of the [4Fe-4S] cluster of recombinant human iron regulatory protein 1.
Topics: Aconitate Hydratase; Blotting, Western; Conserved Sequence; Electrophoretic Mobility Shift Assay; Ferrozine; Humans; Iron Regulatory Protein 1; Iron-Sulfur Proteins; Mercaptoethanol; Molsidomine; Nitrates; Nitric Oxide; Peroxynitrous Acid; Recombinant Proteins; Superoxide Dismutase; Tyrosine | 2003 |
Peroxynitrite generated in the rat spinal cord induces oxidation and nitration of proteins: reduction by Mn (III) tetrakis (4-benzoic acid) porphyrin.
Topics: 2,4-Dinitrophenol; Animals; Drug Interactions; Enzyme Inhibitors; Free Radical Scavengers; Immunohistochemistry; Male; Metalloporphyrins; Microdialysis; Molsidomine; Neurons; Oxidation-Reduction; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Cord Injuries; Time Factors; Tyrosine | 2003 |
Peroxynitrite generated in the rat spinal cord induces apoptotic cell death and activates caspase-3.
Topics: Animals; Apoptosis; Caspase 3; Caspases; DNA Fragmentation; Immunohistochemistry; In Situ Nick-End Labeling; Male; Microdialysis; Microscopy, Electron; Molsidomine; Nitric Oxide Donors; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Cord Injuries | 2003 |
Human sensitive to apoptosis gene protein inhibits peroxynitrite-induced DNA damage.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Antioxidants; Cysteine; Deoxyguanosine; DNA Damage; Dose-Response Relationship, Drug; Ethylmaleimide; Humans; Molsidomine; Peroxynitrous Acid; RNA-Binding Proteins; Sulfhydryl Reagents; Ubiquitin-Protein Ligases | 2003 |
Mitogen-activated protein kinases mediate peroxynitrite-induced cell death in human bronchial epithelial cells.
Topics: Bronchi; Cell Death; Cell Line; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epithelial Cells; Flavonoids; Humans; MAP Kinase Signaling System; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Peroxynitrous Acid; Respiratory Mucosa; Superoxides | 2003 |
Inhibition of actin polymerization by peroxynitrite modulates neutrophil functional responses.
Topics: Actins; Chemotaxis; Dimerization; Dose-Response Relationship, Drug; Humans; Molsidomine; Neutrophil Activation; Neutrophils; Nitric Oxide Donors; Peroxynitrous Acid; Phagocytosis; Reactive Oxygen Species; Respiratory Burst; Tyrosine | 2003 |
The trypanothione-thiol system in Trypanosoma cruzi as a key antioxidant mechanism against peroxynitrite-mediated cytotoxicity.
Topics: Animals; Antioxidants; Biochemistry; Blotting, Western; Chromatography, High Pressure Liquid; Disulfides; Dose-Response Relationship, Drug; Glutathione; Macrophages; Models, Chemical; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitrogen; Oxygen; Peroxynitrous Acid; Sulfhydryl Compounds; Time Factors; Trypanosoma cruzi; Tyrosine | 2003 |
Deactivation of norepinephrine by peroxynitrite as a new pathogenesis in the hypotension of septic shock.
Topics: Anesthesia; Animals; Aorta, Thoracic; Binding, Competitive; Blood Pressure; Hydrogen-Ion Concentration; Hypotension; In Vitro Techniques; Male; Molsidomine; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Oxidation-Reduction; Peroxynitrous Acid; Rats; Rats, Wistar; Shock, Septic; Vasoconstrictor Agents | 2003 |
Three model systems measure oxidation/nitration damage caused by peroxynitrite.
Topics: Antioxidants; DNA Damage; DNA, Superhelical; Escherichia coli; Fruit; Luciferases; Luminescent Measurements; Luminol; Molsidomine; Mutation; Nitrates; Oxidants; Oxidation-Reduction; Peroxynitrous Acid; Phenols; Plasmids; Solutions; Tea | 2003 |
Peroxynitrite-induced oxidation of plasma lipids is enhanced in stable hemodialysis patients.
Topics: Adult; Aged; Aged, 80 and over; F2-Isoprostanes; Female; Humans; Kidney Failure, Chronic; Lipids; Male; Membranes, Artificial; Middle Aged; Molsidomine; Nitric Oxide Donors; Oxidation-Reduction; Peroxynitrous Acid; Renal Dialysis; Tocopherols; Uric Acid | 2003 |
Protective activity of (-)-epicatechin 3-O-gallate against peroxynitrite-mediated renal damage.
Topics: Animals; Antioxidants; Caspases; Catechin; Cell Cycle; Cell Line; Cell Survival; DNA Fragmentation; Dose-Response Relationship, Drug; Flow Cytometry; Glutathione; Glutathione Peroxidase; Kidney; Lipid Peroxides; Lipopolysaccharides; LLC-PK1 Cells; Male; Molsidomine; Peroxynitrous Acid; Rats; Rats, Wistar; Reactive Oxygen Species; Reperfusion Injury; Rhodamines; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Time Factors; Tyrosine | 2003 |
Role of intracellular calcium mobilization and cell-density-dependent signaling in oxidative-stress-induced cytotoxicity in HaCaT keratinocytes.
Topics: Buffers; Calcium; Calcium Signaling; Caspases; Cell Count; Cells, Cultured; Chelating Agents; Cytotoxins; Egtazic Acid; Extracellular Space; Humans; Keratinocytes; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Oxidative Stress; Peroxynitrous Acid; Poly(ADP-ribose) Polymerases | 2003 |
Reactive oxygen species inhibited by titanium oxide coatings.
Topics: Aluminum; Animals; Coated Materials, Biocompatible; Cytokines; Macrophages; Mice; Molsidomine; Peroxynitrous Acid; Phenylacetates; Reactive Oxygen Species; Silicones; Titanium | 2003 |
Toxicity of nitric oxide and peroxynitrite to Photobacterium damselae subsp. piscicida.
Topics: Analysis of Variance; Culture Media; Glucose; Molsidomine; Nitric Oxide; Peroxynitrous Acid; Photobacterium; S-Nitroso-N-Acetylpenicillamine | 2003 |
Peroxynitrite and NO+ donors form colored nitrite adducts with sinapinic acid: potential applications.
Topics: Coumaric Acids; Kinetics; Molsidomine; Nitric Oxide Donors; Nitrites; Nitrous Acid; Peroxynitrous Acid; Rhodamines; S-Nitrosoglutathione | 2003 |
Cyclic AMP and cyclic GMP independent stimulation of ventricular calcium current by peroxynitrite donors in guinea pig myocytes.
Topics: Animals; Calcium; Calcium Channels; Calcium Signaling; Cyclic AMP; Cyclic GMP; Guinea Pigs; Heart Ventricles; Metalloporphyrins; Molsidomine; Myocytes, Cardiac; Nitric Oxide; Nitric Oxide Donors; Peroxynitrous Acid; Pyrogallol; Superoxide Dismutase; Up-Regulation | 2003 |
In vitro reactive nitrating species toxicity in dissociated spinal motor neurons from NFL (-/-) and hNFL (+/+) transgenic mice.
Topics: Animals; Cell Death; Cells, Cultured; Humans; In Vitro Techniques; Mice; Mice, Inbred C57BL; Mice, Transgenic; Molsidomine; Motor Neurons; Neurofilament Proteins; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Nitroso Compounds; Peroxynitrous Acid; Spinal Cord; Superoxide Dismutase; Triazenes | 2003 |
Procyanidins from grape seeds protect endothelial cells from peroxynitrite damage and enhance endothelium-dependent relaxation in human artery: new evidences for cardio-protection.
Topics: 6-Ketoprostaglandin F1 alpha; Antioxidants; Biflavonoids; Catechin; Cell Survival; Cells, Cultured; Endothelin-1; Endothelium; Endothelium, Vascular; Fluoresceins; Fluorescent Dyes; Free Radicals; Humans; In Vitro Techniques; Lipid Peroxidation; Mammary Arteries; Molsidomine; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Peroxynitrous Acid; Proanthocyanidins; Seeds; Vasoconstriction; Vitis | 2003 |
Inhibition of peroxynitrite-mediated LDL oxidation by prenylated flavonoids: the alpha,beta-unsaturated keto functionality of 2'-hydroxychalcones as a novel antioxidant pharmacophore.
Topics: Antioxidants; Bicarbonates; Chalcone; Chalcones; Chromatography, High Pressure Liquid; Flavonoids; Humans; Humulus; Lipid Metabolism; Lipid Peroxidation; Lipoproteins, LDL; Magnetic Resonance Spectroscopy; Molecular Structure; Molsidomine; Oxidation-Reduction; Peroxynitrous Acid; Propiophenones; Spectrophotometry | 2003 |
Peroxynitrite decreases dopamine's vasoconstrictive activity.
Topics: Animals; Aorta, Thoracic; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Molsidomine; Muscle Contraction; Muscle, Smooth, Vascular; Peroxynitrous Acid; Rats; Vasoconstriction | 2003 |
Peroxynitrite irreversibly inactivates the human xenobiotic-metabolizing enzyme arylamine N-acetyltransferase 1 (NAT1) in human breast cancer cells: a cellular and mechanistic study.
Topics: Arylamine N-Acetyltransferase; Breast Neoplasms; Cysteine; Dithiothreitol; Enzyme Inhibitors; Glutathione; Humans; Isoenzymes; Kinetics; Molsidomine; Oxidation-Reduction; Peroxynitrous Acid; Recombinant Proteins; Tumor Cells, Cultured | 2004 |
Inactivation of wild-type p53 protein function by reactive oxygen and nitrogen species in malignant glioma cells.
Topics: Cell Line, Tumor; Doxycycline; Glioblastoma; Humans; Molsidomine; Peroxynitrous Acid; Reactive Nitrogen Species; Reactive Oxygen Species; Transcriptional Activation; Transfection; Tumor Suppressor Protein p53 | 2003 |
Modulation of A1 adenosine receptor signaling by peroxynitrite.
Topics: Animals; Central Nervous System; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine 5'-O-(3-Thiotriphosphate); Male; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Peroxynitrous Acid; Rats; Rats, Wistar; Receptor, Adenosine A1; Signal Transduction; Sulfur Radioisotopes; Tritium | 2004 |
Peroxynitrite-induced apoptosis in photoreceptor cells.
Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Blotting, Western; Caspase 3; Caspase Inhibitors; Caspases; Cysteine Proteinase Inhibitors; DNA; Immunohistochemistry; In Situ Nick-End Labeling; Molsidomine; Nitric Oxide Donors; Peroxynitrous Acid; Photoreceptor Cells, Vertebrate; Rats; Rats, Inbred Lew; Uric Acid | 2004 |
Effects of oxygen on the reactivity of nitrogen oxide species including peroxynitrite.
Topics: Anaerobiosis; Electron Spin Resonance Spectroscopy; Glutathione; Molsidomine; Morpholines; Nitric Oxide; Nitrogen Oxides; Nitrosamines; Nitrous Oxide; Oxygen; Peroxynitrous Acid; S-Nitrosoglutathione; Solutions; Tyrosine | 2004 |
Involvement of the mitogen-activated protein kinase cascade in peroxynitrite-mediated arachidonic acid release in vascular smooth muscle cells.
Topics: Animals; Arachidonic Acid; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Chelating Agents; Dinoprostone; Enzyme Inhibitors; Group IV Phospholipases A2; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Molsidomine; Muscle, Smooth, Vascular; Nitric Oxide; p38 Mitogen-Activated Protein Kinases; Peroxynitrous Acid; Phospholipases A; Rats | 2004 |
Xanthine oxidase converts nitric oxide to nitroxyl that inactivates the enzyme.
Topics: Animals; Cattle; Dose-Response Relationship, Drug; Hemoglobins; Molsidomine; Nitric Oxide; Nitrites; Nitrogen Oxides; Oxygen; Peroxynitrous Acid; Protein Binding; Reactive Nitrogen Species; Spermine; Xanthine; Xanthine Oxidase | 2004 |
Mutations in the extracellular loop of alpha-rENaC alter sensitivity to amiloride and reactive species.
Topics: Amiloride; Animals; Diuretics; Epithelial Sodium Channels; Molsidomine; Mutation; Oocytes; Patch-Clamp Techniques; Peroxynitrous Acid; Reactive Oxygen Species; RNA, Messenger; Sodium Channels; Xenopus laevis | 2004 |
Peroxynitrite decreases rabbit tissue factor activity in vitro.
Topics: Animals; Blood Coagulation; Brain Chemistry; Humans; In Vitro Techniques; Molsidomine; Nitric Oxide Donors; Peroxynitrous Acid; Rabbits; Reperfusion Injury; Superoxide Dismutase; Superoxides; Thrombelastography; Thromboplastin | 2004 |
3-Morpholinosyndnonimine inhibits 5-hydroxytryptamine-induced phosphorylation of nitric oxide synthase in endothelial cells.
Topics: Animals; Cattle; Dose-Response Relationship, Drug; Endothelium, Vascular; Feedback, Physiological; Molsidomine; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Peroxynitrous Acid; Phosphorylation; Serotonin; Serotonin Antagonists | 2003 |
Potent inhibition of peroxynitrite-induced DNA strand breakage by ethanol: possible implications for ethanol-mediated cardiovascular protection.
Topics: Bacteriophage phi X 174; Bicarbonates; Central Nervous System Depressants; DNA Damage; DNA, Viral; Ethanol; Heart Diseases; Molsidomine; Oxidation-Reduction; Oxygen Consumption; Peroxynitrous Acid; Plasmids; Rhodamines | 2004 |
Peroxynitrite inactivates tissue plasminogen activator.
Topics: Antioxidants; Blotting, Western; Dose-Response Relationship, Drug; Humans; Molsidomine; Nitric Oxide; Peroxynitrous Acid; Recombinant Proteins; Superoxide Dismutase; Superoxides; Thrombelastography; Tissue Plasminogen Activator | 2004 |
Increased release of excitatory amino acids by the actions of ATP and peroxynitrite on volume-regulated anion channels (VRACs) in astrocytes.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Astrocytes; Cell Size; Cells, Cultured; Culture Media; Excitatory Amino Acids; Ion Channels; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Osmolar Concentration; Peroxynitrous Acid; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Rats; Rats, Sprague-Dawley | 2004 |
Effect of L-ascorbic acid on the oxidative modification of apolipoprotein E in human very-low-density lipoprotein.
Topics: Amidines; Antioxidants; Apolipoproteins E; Ascorbic Acid; Heparin; Humans; Lipid Peroxidation; Lipoproteins, VLDL; Molsidomine; Oxidants; Peroxides; Peroxynitrous Acid | 2004 |
Reduction of insulin-stimulated glucose uptake by peroxynitrite is concurrent with tyrosine nitration of insulin receptor substrate-1.
Topics: 3T3-L1 Cells; Animals; Binding Sites; Dose-Response Relationship, Drug; Glucose; Insulin; Insulin Receptor Substrate Proteins; Mice; Molsidomine; Nitrates; Peroxynitrous Acid; Phosphoproteins; Protein Binding; Rats; Tyrosine | 2004 |
Protective properties of neoechinulin A against SIN-1-induced neuronal cell death.
Topics: Alkaloids; Animals; Antioxidants; Apoptosis; Caspase 3; Caspases; Dose-Response Relationship, Drug; Molsidomine; Neurons; Oxidative Stress; PC12 Cells; Peroxynitrous Acid; Piperazines; Rats; Reactive Oxygen Species | 2004 |
Peroxynitrite decreases hemostasis in human plasma in vitro.
Topics: Blood Coagulation Factors; Blotting, Western; Coagulants; Dose-Response Relationship, Drug; Factor X; Hemostasis; Humans; In Vitro Techniques; Molsidomine; Nitric Oxide Donors; Partial Thromboplastin Time; Peroxynitrous Acid; Plasma; Protein C; Prothrombin Time; Superoxide Dismutase; Thrombelastography; Tyrosine | 2004 |
GEA 3162 decomposes to co-generate nitric oxide and superoxide and induces apoptosis in human neutrophils via a peroxynitrite-dependent mechanism.
Topics: Apoptosis; Cell Separation; Electrochemistry; Electron Spin Resonance Spectroscopy; Fluorescent Dyes; Humans; In Vitro Techniques; Molsidomine; Neutrophils; Nitric Oxide; Nitric Oxide Donors; Peroxynitrous Acid; Rhodamines; Superoxides; Triazoles | 2004 |
3-Morpholinylsydnonimine inhibits glutamatergic transmission in rat rostral ventrolateral medulla via peroxynitrite formation and adenosine release.
Topics: Adenosine; Animals; Calcium Channels, N-Type; Glutamic Acid; In Vitro Techniques; Male; Medulla Oblongata; Molsidomine; Nitric Oxide Donors; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Synaptic Transmission | 2004 |
Peroxynitrite alters the catalytic activity of rodent liver proteasome in vitro and in vivo.
Topics: Animals; Catalysis; Cysteine Endopeptidases; Dose-Response Relationship, Drug; Liver; Mice; Mice, Inbred C57BL; Molsidomine; Multienzyme Complexes; Peroxynitrous Acid; Proteasome Endopeptidase Complex; Rats; S-Nitroso-N-Acetylpenicillamine | 2004 |
PKC downstream of Pl3-kinase regulates peroxynitrite formation for Nrf2-mediated GSTA2 induction.
Topics: Animals; Cell Line; Chromones; DNA-Binding Proteins; Enzyme Activation; Glutathione Transferase; Hepatocytes; Hydroquinones; Immunoblotting; Molsidomine; Morpholines; NF-E2-Related Factor 2; Peroxynitrous Acid; Phosphatidylinositol 3-Kinases; Protein Kinase C; Rats; Reactive Oxygen Species; Tetradecanoylphorbol Acetate; Trans-Activators | 2004 |
Interference of 7,8-dihydroneopterin with peroxynitrite-mediated reactions.
Topics: Electron Spin Resonance Spectroscopy; Free Radical Scavengers; Hydroxylation; Luminescent Measurements; Molsidomine; Neopterin; Oxidation-Reduction; Peroxynitrous Acid; Piperidines; Salicylic Acid; Spectrometry, Fluorescence; Superoxides; Tyrosine | 2004 |
Highly selective and prolonged depletion of mitochondrial glutathione in astrocytes markedly increases sensitivity to peroxynitrite.
Topics: Adenosine Triphosphate; Animals; Astrocytes; Brain; Cell Death; Cells, Cultured; Citrate (si)-Synthase; Cyclosporine; Cytoplasm; Electron Transport; Electron Transport Complex I; Ethacrynic Acid; Glutathione; Intracellular Membranes; L-Lactate Dehydrogenase; Membrane Potentials; Mitochondria; Molsidomine; Oxidative Stress; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley | 2004 |
Caspase-1 and poly (ADP-ribose) polymerase inhibitors may protect against peroxynitrite-induced neurotoxicity independent of their enzyme inhibitor activity.
Topics: Adenosine Triphosphate; Amino Acid Chloromethyl Ketones; Animals; Caspase Inhibitors; Cells, Cultured; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Kinetics; Molsidomine; Neurons; Peroxynitrous Acid; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Rats; Rats, Sprague-Dawley | 2004 |
Calcium mobilization is required for peroxynitrite-mediated enhancement of spontaneous transient outward currents in arteriolar smooth muscle cells.
Topics: Animals; Boron Compounds; Caffeine; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Electrophysiology; Female; Male; Membrane Potentials; Models, Biological; Molsidomine; Muscle, Smooth; Myocytes, Smooth Muscle; Nifedipine; Patch-Clamp Techniques; Peroxynitrous Acid; Potassium; Rats; Rats, Wistar; Ryanodine; Signal Transduction; Time Factors | 2004 |
Intracellular pH-dependent peroxynitrite-evoked synergistic death of glucose-deprived astrocytes.
Topics: Amiloride; Ammonium Chloride; Anaerobiosis; Animals; Astrocytes; Brain Ischemia; Caspases; Cyclosporine; Glucose; Glutathione; Hydrogen-Ion Concentration; Intracellular Fluid; Intracellular Membranes; L-Lactate Dehydrogenase; Membrane Potentials; Mitochondria; Molsidomine; Oxidation-Reduction; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Sodium Acetate; Sodium-Hydrogen Exchangers | 2004 |
Heme oxygenase-1 mediates up-regulation of adhesion molecule expression induced by peroxynitrite in endothelial cells.
Topics: Cell Adhesion Molecules; Cells, Cultured; E-Selectin; Endothelial Cells; Gene Expression; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Membrane Proteins; Molsidomine; Nitric Oxide Donors; Oxidative Stress; P-Selectin; Peroxynitrous Acid; RNA, Messenger; Umbilical Veins; Vascular Cell Adhesion Molecule-1 | 2004 |
Protecting against peroxynitrite-mediated cytotoxicity in vascular smooth muscle cells via upregulating endogenous glutathione biosynthesis by 3H-1,2-dithiole-3-thione.
Topics: Animals; Antineoplastic Agents; Buthionine Sulfoximine; Cell Survival; Cells, Cultured; Dipeptides; Dose-Response Relationship, Drug; Drug Antagonism; Drug Combinations; Glutathione; Molsidomine; Muscle, Smooth, Vascular; Peroxynitrous Acid; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiones; Thiophenes; Up-Regulation | 2004 |
Reactivity of 1,4-dihydropyridines toward SIN-1-derived peroxynitrite.
Topics: Deuterium; Dihydropyridines; Electron Spin Resonance Spectroscopy; Gas Chromatography-Mass Spectrometry; Indicators and Reagents; Kinetics; Magnetic Resonance Spectroscopy; Molsidomine; Oxidation-Reduction; Peroxynitrous Acid; Solutions; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared | 2004 |
Peroxynitrite-induced neuronal apoptosis is mediated by intracellular zinc release and 12-lipoxygenase activation.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Arachidonate 12-Lipoxygenase; Caspase 3; Caspases; Cells, Cultured; Chelating Agents; Enzyme Activation; Ethylenediamines; Free Radicals; Glutathione; Membrane Potentials; Microscopy, Fluorescence; Mitochondria; Molsidomine; Neurons; p38 Mitogen-Activated Protein Kinases; Peroxynitrous Acid; Rats; Spectrometry, Fluorescence; Zinc | 2004 |
Propofol attenuates peroxynitrite-mediated DNA damage and apoptosis in cultured astrocytes: an alternative protective mechanism.
Topics: Anesthetics, Intravenous; Animals; Apoptosis; Astrocytes; Blotting, Western; Caspase 3; Caspases; Cells, Cultured; Comet Assay; DNA; DNA Damage; Enzyme Activation; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; L-Lactate Dehydrogenase; Molsidomine; Oxidative Stress; Peroxynitrous Acid; Propofol; Rats; Rats, Wistar; Tetrazolium Salts; Thiazoles | 2004 |
Fluorescence measurements of steady state peroxynitrite production upon SIN-1 decomposition: NADH versus dihydrodichlorofluorescein and dihydrorhodamine 123.
Topics: Fluoresceins; Molsidomine; NAD; Peroxynitrous Acid; Rhodamines; Spectrometry, Fluorescence | 2004 |
Alteration of cytosolic free calcium homeostasis by SIN-1: high sensitivity of L-type Ca2+ channels to extracellular oxidative/nitrosative stress in cerebellar granule cells.
Topics: Animals; Calcium; Calcium Channels, L-Type; Cell Survival; Cells, Cultured; Cerebellum; Cytosol; Dose-Response Relationship, Drug; Homeostasis; Molsidomine; Oxidative Stress; Peroxynitrous Acid; Rats; Rats, Wistar | 2005 |
Curcumin overcomes the inhibitory effect of nitric oxide on Leishmania.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Curcumin; Leishmania donovani; Leishmania major; Mice; Mice, Inbred BALB C; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitroso Compounds; Penicillamine; Peroxynitrous Acid | 2005 |
Protective role of Coptidis Rhizoma alkaloids against peroxynitrite-induced damage to renal tubular epithelial cells.
Topics: Alkaloids; Animals; Cell Survival; Coptis chinensis; DNA Fragmentation; Drugs, Chinese Herbal; Kidney Tubules; LLC-PK1 Cells; Molecular Structure; Molsidomine; Peroxynitrous Acid; Swine; Urothelium | 2005 |
Peroxynitrite provides the peroxide tone for PGHS-2-dependent prostacyclin synthesis in vascular smooth muscle cells.
Topics: Animals; Cattle; Cells, Cultured; Cyclooxygenase 2; Epoprostenol; Hydrogen Peroxide; Molsidomine; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitric Oxide; Nitric Oxide Synthase; Nitrogen Oxides; Peroxynitrous Acid; Spermine; Superoxides | 2005 |
Protein phosphatase 1alpha is tyrosine-phosphorylated and inactivated by peroxynitrite in erythrocytes through the src family kinase fgr.
Topics: Down-Regulation; Enzyme Activation; Erythrocytes; Humans; K Cl- Cotransporters; Molsidomine; Peroxynitrous Acid; Phosphoprotein Phosphatases; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-hck; src-Family Kinases; Symporters; Tyrosine | 2005 |
Peroxynitrite-mediated matrix metalloproteinase-2 activation in human hepatic stellate cells.
Topics: Cell Line; Collagenases; Enzyme Activation; Hepatocytes; Humans; I-kappa B Proteins; Matrix Metalloproteinase 1; Matrix Metalloproteinase 13; Matrix Metalloproteinase 2; Matrix Metalloproteinases, Membrane-Associated; Metalloendopeptidases; Mitogen-Activated Protein Kinases; Molsidomine; NF-kappa B; NF-KappaB Inhibitor alpha; Nitrates; Penicillamine; Peroxynitrous Acid; Phosphorylation; RNA, Messenger; Tissue Inhibitor of Metalloproteinase-1 | 2005 |
Impairment of the activity of the xenobiotic-metabolizing enzymes arylamine N-acetyltransferases 1 and 2 (NAT1/NAT2) by peroxynitrite in mouse skeletal muscle cells.
Topics: Acetyl Coenzyme A; Acetyltransferases; Amino Acid Transport System A; Amino Acid Transport Systems; Animals; Arylamine N-Acetyltransferase; Cell Line; Glutathione; Humans; Isoenzymes; Mice; Molsidomine; Muscle Fibers, Skeletal; Muscle, Skeletal; Nitric Oxide Donors; Peroxynitrous Acid; Xenobiotics | 2005 |
Adenosine and purine nucleosides prevent the disruption of mitochondrial transmembrane potential by peroxynitrite in rat primary astrocytes.
Topics: Adenosine; Animals; Astrocytes; Brain Ischemia; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Glucose; Intracellular Membranes; Membrane Potentials; Mitochondria; Molsidomine; Peroxynitrous Acid; Purine Nucleosides; Rats; Rats, Sprague-Dawley; Sodium-Potassium-Exchanging ATPase | 2005 |
Mitogen-activated protein kinases (MAPKs) mediate SIN-1/ glucose deprivation-induced death in rat primary astrocytes.
Topics: Adenosine Triphosphate; Animals; Anthracenes; Astrocytes; Brain Ischemia; Cell Culture Techniques; Cell Death; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Glucose; Imidazoles; L-Lactate Dehydrogenase; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Molsidomine; Nitric Oxide Donors; p38 Mitogen-Activated Protein Kinases; Peroxynitrous Acid; Pyridines; Rats; Rats, Sprague-Dawley | 2005 |
Propofol inhibits caspase-3 in astroglial cells: role of heme oxygenase-1.
Topics: Animals; Antioxidants; Astrocytes; Blotting, Western; Caspase 3; Caspase Inhibitors; Caspases; Cell Survival; Cells, Cultured; Enzyme Activation; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Molsidomine; Nitric Oxide Donors; Peroxynitrous Acid; Propofol; Rats; Rats, Wistar | 2005 |
Role of endogenous melatonin in the oxidative homeostasis of the extracellular striatal compartment: a microdialysis study in PC12 cells in vitro and in the striatum of freely moving rats.
Topics: Animals; Corpus Striatum; Dehydroascorbic Acid; Dopamine; Homeostasis; Light; Male; Melatonin; Microdialysis; Molsidomine; PC12 Cells; Peroxynitrous Acid; Rats; Rats, Wistar | 2005 |
Peroxynitrite causes endoplasmic reticulum stress and apoptosis in human vascular endothelium: implications in atherogenesis.
Topics: Animals; Aorta; Apolipoproteins E; Apoptosis; Atherosclerosis; Calcium; Cells, Cultured; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Endothelium, Vascular; Female; Homeostasis; Humans; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Oxidative Stress; Peroxynitrous Acid; Superoxides; Tyrosine; Umbilical Veins | 2005 |
Peroxynitrite generated at the level produced by spinal cord injury induces peroxidation of membrane phospholipids in normal rat cord: reduction by a metalloporphyrin.
Topics: Aldehydes; Animals; Cell Membrane; Free Radical Scavengers; Lipid Peroxidation; Male; Malondialdehyde; Metalloporphyrins; Molsidomine; Nitric Oxide Donors; Peroxynitrous Acid; Phospholipids; Rats; Rats, Sprague-Dawley; Spinal Cord Injuries | 2005 |
Ethanol metabolism alters interferon gamma signaling in recombinant HepG2 cells.
Topics: Blotting, Western; Cell Line; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Ethanol; Humans; Interferon-gamma; Intracellular Signaling Peptides and Proteins; Molsidomine; Nitric Oxide Donors; Oxidation-Reduction; Peroxynitrous Acid; Phosphorylation; Repressor Proteins; Signal Transduction; STAT1 Transcription Factor; Suppressor of Cytokine Signaling 1 Protein; Suppressor of Cytokine Signaling Proteins | 2005 |
Initiation of a superoxide-dependent chain oxidation of lactate dehydrogenase-bound NADH by oxidants of low and high reactivity.
Topics: Animals; Hydrogen Peroxide; Kinetics; L-Lactate Dehydrogenase; Molsidomine; NAD; NADP; Oxidants; Oxidation-Reduction; Oxygen; Peroxynitrous Acid; Spectrometry, Fluorescence; Superoxide Dismutase; Superoxides; Swine | 2005 |
Effects of peroxynitrite and superoxide radicals on endothelial monolayer permeability: potential role of peroxynitrite in preeclampsia.
Topics: Cell Membrane Permeability; Cells, Cultured; Electric Impedance; Endothelium, Vascular; Female; Focal Adhesion Protein-Tyrosine Kinases; Horseradish Peroxidase; Humans; Intercellular Junctions; Molsidomine; Nitric Oxide Donors; Oxidative Stress; Peroxynitrous Acid; Pre-Eclampsia; Pregnancy; Superoxide Dismutase; Umbilical Cord | 2005 |
Heme catalyzes tyrosine 385 nitration and inactivation of prostaglandin H2 synthase-1 by peroxynitrite.
Topics: Amino Acid Sequence; Animals; Apoenzymes; Binding Sites; Catalysis; Chromatography, Ion Exchange; Cyclooxygenase 1; Electrophoresis, Polyacrylamide Gel; Free Radical Scavengers; Heme; Hemin; Holoenzymes; Hydroxyl Radical; Male; Models, Chemical; Molecular Sequence Data; Molsidomine; Peroxynitrous Acid; Seminal Vesicles; Sheep; Tyrosine | 2006 |
Therapeutic action of cannabinoid on axonal injury induced by peroxynitrite.
Topics: Adrenalectomy; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Axons; Brain Diseases; Cannabinoids; Corpus Callosum; Corticosterone; Disease Models, Animal; Dronabinol; Drug Therapy, Combination; Enzyme Inhibitors; Immunohistochemistry; Male; Molsidomine; Morpholines; Peroxynitrous Acid; Pyrazoles; Rats; Rats, Wistar | 2006 |
Peroxynitrite induces F-actin depolymerization and blockade of myosin ATPase stimulation.
Topics: Actins; Animals; Calorimetry, Differential Scanning; Enzyme Activation; Molsidomine; Myosins; Oxidation-Reduction; Peroxynitrous Acid; Protein Denaturation; Protein Folding; Rabbits; Temperature; Tyrosine | 2006 |
Effects of peroxynitrite and lipopolysaccharide on mitotic activity of C6 glioma cells.
Topics: Animals; Apoptosis; Cell Line, Tumor; Escherichia coli; Glioma; Lipopolysaccharides; Luminescent Measurements; Mitogens; Mitosis; Molsidomine; Nitric Oxide Donors; Peroxynitrous Acid; Rats | 2006 |
Green tea polyphenol epigallocatechin-3-gallate protects cells against peroxynitrite-induced cytotoxicity: modulatory effect of cellular G6PD status.
Topics: Apoptosis; Camellia sinensis; Catechin; Cell Line; Cell Survival; Fibroblasts; Glucosephosphate Dehydrogenase; Glucosephosphate Dehydrogenase Deficiency; Glutathione; Humans; Molsidomine; Oxidation-Reduction; Peroxynitrous Acid; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Tumor Suppressor Protein p53 | 2006 |
Inhibition of skeletal muscle S1-myosin ATPase by peroxynitrite.
Topics: Actins; Adenosine Diphosphate; Adenosine Triphosphatases; Animals; Catalysis; Cysteine; Dose-Response Relationship, Drug; Enzyme Stability; Magnesium; Molsidomine; Myosin Subfragments; Oxidation-Reduction; Peroxynitrous Acid; Protein Folding; Rabbits; Skeletal Muscle Myosins; Temperature; Time Factors; Tyrosine | 2006 |
Peroxynitrite generation and tyrosine nitration in defense responses in tobacco BY-2 cells.
Topics: Algal Proteins; Aniline Compounds; Antibodies, Anti-Idiotypic; Cells, Cultured; Cyclic GMP; Fluoresceins; Fungal Proteins; Molsidomine; Nicotiana; Nitric Oxide; Peroxynitrous Acid; Phytophthora; Proteins; Reactive Oxygen Species; Superoxides; Tyrosine; Uric Acid | 2006 |
Protection of peroxynitrite-induced DNA damage by dietary antioxidants.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Catechin; Deoxyguanosine; Diet; DNA; DNA Damage; Free Radical Scavengers; Humans; Molsidomine; Peroxynitrous Acid; Resveratrol; Stilbenes; Triterpenes; U937 Cells; Ursolic Acid | 2006 |
Carbon monoxide protects PC12 cells from peroxynitrite-induced apoptotic death by preventing the depolarization of mitochondrial transmembrane potential.
Topics: Animals; Apoptosis; Carbon Monoxide; Cells, Cultured; Heme Oxygenase-1; Intracellular Membranes; Membrane Potentials; Mitochondrial Membranes; Models, Biological; Molsidomine; PC12 Cells; Peroxynitrous Acid; Rats; Tin Compounds | 2006 |
Effect of lycopene and beta-carotene on peroxynitrite-mediated cellular modifications.
Topics: Animals; Antioxidants; beta Carotene; Carotenoids; Cell Line; Cell Survival; Comet Assay; Cricetinae; Cricetulus; DNA Damage; Lycopene; Molsidomine; Nitric Oxide Donors; Peroxynitrous Acid; Tyrosine | 2006 |
Reactive nitrogen species induce nuclear factor-kappaB-mediated protein degradation in skeletal muscle cells.
Topics: Animals; Antioxidants; Cells, Cultured; Metalloendopeptidases; Molsidomine; Muscle Cells; Muscle Fibers, Skeletal; Muscle Proteins; Muscle, Skeletal; Myosin Heavy Chains; NF-kappa B; Nitric Oxide Donors; Penicillamine; Peroxynitrous Acid; Proteasome Endopeptidase Complex; Rats; Reactive Nitrogen Species; Tyrosine; Ubiquitin | 2006 |
Modulation of peroxynitrite-induced fibroblast injury by hesperetin: a role for intracellular scavenging and modulation of ERK signalling.
Topics: Cells, Cultured; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Hesperidin; Humans; Molsidomine; Nitric Oxide Donors; Peroxynitrous Acid; Signal Transduction; Tyrosine | 2006 |
Thioredoxin reduces post-ischemic myocardial apoptosis by reducing oxidative/nitrative stress.
Topics: Animals; Apoptosis; Male; Mice; Molsidomine; Myocardial Ischemia; Myocardium; Myocytes, Cardiac; Nitric Oxide; Oxidative Stress; Peroxynitrous Acid; Superoxides; Thioredoxins; Tyrosine | 2006 |
Nitric oxide and peroxynitrite have different antiviral effects against hantavirus replication and free mature virions.
Topics: Animals; Antiviral Agents; Blotting, Western; Brain; Cells, Cultured; Chlorocebus aethiops; Hantavirus Infections; Humans; In Vitro Techniques; Mice; Mice, Inbred C57BL; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type II; Orthohantavirus; Peroxynitrous Acid; Reverse Transcriptase Polymerase Chain Reaction; S-Nitroso-N-Acetylpenicillamine; Vero Cells; Virion; Virus Replication | 2006 |
Peroxynitrite induces HO-1 expression via PI3K/Akt-dependent activation of NF-E2-related factor 2 in PC12 cells.
Topics: Animals; Enzyme Activation; Gene Expression Regulation; Heme Oxygenase-1; Membrane Potentials; Molsidomine; NF-E2-Related Factor 2; Nuclear Proteins; PC12 Cells; Peroxynitrous Acid; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats | 2006 |
Nitrative inactivation of thioredoxin-1 and its role in postischemic myocardial apoptosis.
Topics: Amino Acid Substitution; Animals; Apoptosis; Cardiotonic Agents; Cyclic N-Oxides; Free Radical Scavengers; Humans; Imidazoles; Male; MAP Kinase Kinase Kinase 5; MAP Kinase Signaling System; Metalloporphyrins; Mice; Molsidomine; Mutagenesis, Site-Directed; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; NADP; Oxidation-Reduction; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Peroxynitrous Acid; Thioredoxins | 2006 |
The role of reactive nitrogen species and cigarette smoke in activation of transcription factor NF-kappaB and implication to inflammatory processes.
Topics: Animals; Cell Line; Cells, Cultured; Humans; Inflammation; Lymphocytes; Molsidomine; NF-kappa B; Nicotiana; Nitric Oxide Donors; Penicillamine; Peroxynitrous Acid; Rats; Smoke | 2006 |
Inhibition of caspase-mediated apoptosis by peroxynitrite in traumatic brain injury.
Topics: Animals; Apoptosis; Blotting, Western; Brain Injuries; Caspases; Cells, Cultured; Cerebral Cortex; Cytochromes c; Disease Models, Animal; Embryo, Mammalian; Enzyme Inhibitors; Immunohistochemistry; In Situ Nick-End Labeling; Male; Mice; Molsidomine; N-Methylaspartate; Neural Inhibition; Neurons; Nitric Oxide Donors; Peroxynitrous Acid; Physical Stimulation; Rats; Rats, Sprague-Dawley; Staurosporine | 2006 |
Lens thiol depletion by peroxynitrite. Protective effect of pyruvate.
Topics: Animals; Decarboxylation; Glutathione; Lens, Crystalline; Molsidomine; Nitric Oxide Donors; Peroxynitrous Acid; Pyruvates; Rats; Sulfhydryl Compounds | 2007 |
Peroxynitrite mild nitration of albumin and LDL-albumin complex naturally present in plasma and tyrosine nitration rate-albumin impairs LDL nitration.
Topics: Antioxidants; Atherosclerosis; Humans; Lipoproteins, LDL; Molsidomine; Nitric Oxide Donors; Nitrogen Dioxide; Oxidation-Reduction; Peroxynitrous Acid; Serum Albumin; Tyrosine | 2007 |
Inhibition of peroxynitrite precursors, NO and O2, at the onset of reperfusion improves myocardial recovery.
Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Free Radical Scavengers; Male; Molsidomine; Myocardial Contraction; Myocardial Reperfusion Injury; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxygen Consumption; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Recovery of Function; Sodium-Potassium-Exchanging ATPase; Superoxide Dismutase; Treatment Outcome; Ventricular Function, Left | 2007 |
Peroxynitrite-mediated oxidative damage to brain mitochondria: Protective effects of peroxynitrite scavengers.
Topics: Aldehydes; Animals; Cell Respiration; Cerebral Cortex; Cyclic N-Oxides; Dose-Response Relationship, Drug; Electron Transport Complex I; Free Radical Scavengers; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Mitochondria; Molsidomine; Nitric Oxide Donors; Oxidative Stress; Oxygen Consumption; Penicillamine; Peroxynitrous Acid; Protein Carbonylation; Spin Labels; Tyrosine | 2007 |
Carbon monoxide produced by heme oxygenase-1 in response to nitrosative stress induces expression of glutamate-cysteine ligase in PC12 cells via activation of phosphatidylinositol 3-kinase and Nrf2 signaling.
Topics: Animals; Carbon Monoxide; Catalytic Domain; Cell Survival; Glutamate-Cysteine Ligase; Heme Oxygenase (Decyclizing); Molsidomine; NF-E2-Related Factor 2; Nitric Oxide Donors; PC12 Cells; Peroxynitrous Acid; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Protoporphyrins; Rats; RNA, Small Interfering; Signal Transduction; Stress, Physiological | 2007 |
Nitration of a critical tyrosine residue in the allosteric inhibitor site of muscle glycogen phosphorylase impairs its catalytic activity.
Topics: Allosteric Regulation; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Glycogen Phosphorylase, Muscle Form; Mice; Models, Molecular; Molsidomine; Muscle Fibers, Skeletal; Muscle, Skeletal; Nitric Oxide Donors; Peroxynitrous Acid; Protein Structure, Tertiary; Tyrosine | 2007 |
Interferon-beta is neuroprotective against the toxicity induced by activated microglia.
Topics: Animals; Cells, Cultured; Coculture Techniques; Cytokines; Excitatory Amino Acid Agonists; Female; Glutamic Acid; Interferon Type I; Interleukin-1beta; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Microglia; Molsidomine; N-Methylaspartate; Neurons; Neuroprotective Agents; Nitric Oxide; Peroxynitrous Acid; Pregnancy; Recombinant Proteins; Superoxides; Tumor Necrosis Factor-alpha | 2007 |
Chemical-biological fingerprinting: probing the properties of DNA lesions formed by peroxynitrite.
Topics: Chromatography, High Pressure Liquid; DNA Damage; Escherichia coli; Guanine; Molsidomine; Mutation; Peroxynitrous Acid; SOS Response, Genetics; Spectrometry, Mass, Electrospray Ionization | 2007 |
Structure-activity relationships of neoechinulin A analogues with cytoprotection against peroxynitrite-induced PC12 cell death.
Topics: Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Cell Death; Cell Survival; Cytoprotection; Indicators and Reagents; Indole Alkaloids; Luminol; Molsidomine; NADPH Dehydrogenase; Neurons; Neuroprotective Agents; Oxidation-Reduction; PC12 Cells; Peroxynitrous Acid; Piperazines; Rats; Reactive Nitrogen Species; Structure-Activity Relationship | 2007 |
Activity and subcellular trafficking of the sodium-coupled choline transporter CHT is regulated acutely by peroxynitrite.
Topics: Animals; Biotinylation; Cell Culture Techniques; Cell Line; Cell Line, Tumor; Cell Membrane; Choline; Cholinergic Agents; Culture Media; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation; Hemicholinium 3; Humans; Inhibitory Concentration 50; Kidney; Kinetics; L-Lactate Dehydrogenase; Luminescence; Membrane Potentials; Membrane Transport Proteins; Molsidomine; Neuroblastoma; Nitrogen; Oxidative Stress; Peroxynitrous Acid; Protein Transport; Rats; Sodium; Subcellular Fractions; Time Factors; Transfection; Tyrosine | 2008 |
Peroxynitrite donor impairs excitability of hippocampal CA1 neurons by inhibiting voltage-gated potassium currents.
Topics: Animals; Free Radical Scavengers; Hippocampus; In Vitro Techniques; Male; Metalloporphyrins; Molsidomine; Neurons; Nitric Oxide Donors; Peroxynitrous Acid; Potassium Channels, Voltage-Gated; Rats; Rats, Wistar | 2007 |
Targeting of phospholamban by peroxynitrite decreases beta-adrenergic stimulation in cardiomyocytes.
Topics: Animals; Calcium-Binding Proteins; Isoproterenol; Mice; Molsidomine; Myocardial Contraction; Myocytes, Cardiac; Peroxynitrous Acid; Phosphorylation; Protein Phosphatase 1; Protein Phosphatase 2; Receptors, Adrenergic, beta; Serine | 2008 |
Glutathione production is regulated via distinct pathways in stressed and non-stressed cortical neurons.
Topics: Animals; Cell Survival; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Flavonols; Glutathione; MAP Kinase Signaling System; Molsidomine; Neurons; Neuroprotective Agents; NF-E2-Related Factor 2; Nitric Oxide Donors; Nitro Compounds; Oxidative Stress; Peroxynitrous Acid; Phosphorylation; Proto-Oncogene Proteins c-myc; Rats; Rats, Sprague-Dawley; Signal Transduction | 2008 |
Peroxynitrite participates in mechanisms involved in capacitation of cryopreserved cattle.
Topics: Acrosome Reaction; Animals; Cattle; Cryopreservation; Cyclic AMP-Dependent Protein Kinases; Female; Follicular Fluid; Genistein; Heparin; Indoles; Male; Maleimides; Molsidomine; Peroxynitrous Acid; Protein Kinase C; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Semen Preservation; Sperm Capacitation; Spermatozoa | 2009 |
Lignans from the fruits of Forsythia suspensa.
Topics: Animals; Antioxidants; Chromatography, High Pressure Liquid; Forsythia; Fruit; Furans; Glucosides; Lignans; LLC-PK1 Cells; Magnetic Resonance Spectroscopy; Molecular Structure; Molsidomine; Nitric Oxide Donors; Oxidative Stress; Peroxynitrous Acid; Plant Extracts; Swine | 2008 |
Cytoprotective effect of baicalein against peroxynitrite-induced toxicity in LLC-PK(1) cells.
Topics: Animals; Antioxidants; Cell Survival; Enzyme Inhibitors; Flavanones; Free Radical Scavengers; L-Lactate Dehydrogenase; LLC-PK1 Cells; Molsidomine; Peroxynitrous Acid; Swine | 2008 |
Degradation of extracellular matrix by peroxynitrite/peroxynitrous acid.
Topics: Animals; Bicarbonates; Cells, Cultured; Extracellular Matrix; Hydrogen-Ion Concentration; Molecular Structure; Molsidomine; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Peroxynitrous Acid; Rats; Swine; Tyrosine | 2008 |
Human neutrophil-pulmonary microvascular endothelial cell interactions in vitro: differential effects of nitric oxide vs. peroxynitrite.
Topics: 12E7 Antigen; Antibodies, Monoclonal; Antigens, CD; CD18 Antigens; Cell Adhesion; Cell Adhesion Molecules; Cell Communication; Cell Movement; Cells, Cultured; Cytokines; Endothelial Cells; Humans; Imines; Metalloporphyrins; Molsidomine; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Platelet Endothelial Cell Adhesion Molecule-1 | 2008 |
The peroxynitrite donor 3-morpholinosydnonimine induces reversible changes in electrophysiological properties of neurons of the guinea-pig spinal cord.
Topics: Action Potentials; Animals; Axons; Cell Membrane; Dose-Response Relationship, Drug; Extracellular Fluid; Female; Guinea Pigs; Molsidomine; Nerve Degeneration; Neural Conduction; Neurons; Nitric Oxide; Nitric Oxide Donors; Nitro Compounds; Peroxynitrous Acid; Sodium Channels; Spinal Cord; Spinal Cord Injuries; Tyrosine | 2008 |
Active compounds isolated from traditional Chinese prescription Wen-Pi-Tang protecting against peroxynitrite-induced LLC-PK(1) cell damage.
Topics: Animals; Apoptosis; Catechin; Cell Line; Drugs, Chinese Herbal; Epithelial Cells; Free Radicals; Kidney Tubules; Medicine, Chinese Traditional; Molsidomine; Nitric Oxide Donors; Peroxynitrous Acid; Swine | 2008 |
LDL protein nitration: implication for LDL protein unfolding.
Topics: Animals; Aorta; Apolipoprotein B-100; Cattle; Cells, Cultured; Cysteine; Dose-Response Relationship, Drug; Endothelial Cells; Endothelium, Vascular; Humans; Lipid Peroxidation; Lipid Peroxides; Lipoproteins, LDL; Models, Chemical; Molsidomine; Oxidation-Reduction; Peroxynitrous Acid; Protein Conformation; Protein Denaturation; Protein Processing, Post-Translational; Protein Structure, Secondary; Proteins; Reproducibility of Results; Tyrosine | 2008 |
The metalloporphyrin FeTPPS but not by cyclosporin A antagonizes the interaction of peroxynitrate and hydrogen peroxide on cardiomyocyte cell death.
Topics: Animals; Cell Death; Cell Survival; Cells, Cultured; Chick Embryo; Cyclosporine; Drug Interactions; Free Radical Scavengers; Hydrogen Peroxide; Metalloporphyrins; Mitochondria; Molsidomine; Myocytes, Cardiac; Nitric Oxide; Peroxynitrous Acid; Reactive Oxygen Species; Superoxides | 2009 |
Peroxynitrite augments fibroblast-mediated tissue remodeling via myofibroblast differentiation.
Topics: Actins; Antibodies; Cell Differentiation; Cell Nucleus; Cells, Cultured; Collagen Type I; Desmin; Fetus; Fibroblasts; Fibronectins; Humans; Leupeptins; Lung; Molsidomine; Myoblasts; Neutralization Tests; NF-kappa B; Peroxynitrous Acid; Protein Transport; Transforming Growth Factor beta | 2008 |
Nitric oxide and peroxynitrite regulate transporter transcription in rat liver slices.
Topics: Animals; Aspartate Aminotransferases; Carrier Proteins; Gadolinium; In Vitro Techniques; Interleukin-1beta; Liver; Male; Molsidomine; Nitrates; Nitric Oxide; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spermine; Transcription, Genetic; Tumor Necrosis Factor-alpha | 2008 |
Physiopathological effects of the NO donor 3-morpholinosydnonimine on rat cortical synaptosomes.
Topics: Adenosine Triphosphate; Animals; Antioxidants; Cerebral Cortex; Chromans; In Vitro Techniques; L-Lactate Dehydrogenase; Membrane Potential, Mitochondrial; Mitochondria; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Oxidation-Reduction; Oxygen Consumption; Peroxynitrous Acid; Phosphatidylserines; Rats; Reactive Oxygen Species; Synaptosomes; Water | 2009 |
Cisplatin upregulates mitochondrial nitric oxide synthase and peroxynitrite formation to promote renal injury.
Topics: Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Caspase 3; Cisplatin; Coloring Agents; Cytochromes c; Cytoskeleton; Immunohistochemistry; Kidney Diseases; Male; Mitochondria; Molsidomine; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Peroxynitrous Acid; Phalloidine; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2009 |
Synthesis and biological activities of neoechinulin A derivatives: new aspects of structure-activity relationships for neoechinulin A.
Topics: Animals; Antioxidants; Brain Chemistry; Cell Survival; Indicators and Reagents; Indole Alkaloids; Lipid Peroxidation; Magnetic Resonance Spectroscopy; Molsidomine; Nitrates; PC12 Cells; Peroxynitrous Acid; Piperazines; Protective Agents; Rats; Structure-Activity Relationship; Tyrosine | 2008 |
Alpha-lipoic acid potently inhibits peroxynitrite-mediated DNA strand breakage and hydroxyl radical formation: implications for the neuroprotective effects of alpha-lipoic acid.
Topics: Animals; Antioxidants; DNA Breaks, Double-Stranded; Electron Spin Resonance Spectroscopy; Humans; Hydroxyl Radical; Molsidomine; Neuroprotective Agents; Nitric Oxide Donors; Oxidative Stress; Oxygen Consumption; Peroxynitrous Acid; Thioctic Acid | 2009 |
Modification of surfactant protein D by reactive oxygen-nitrogen intermediates is accompanied by loss of aggregating activity, in vitro and in vivo.
Topics: Amino Acid Sequence; Animals; Bronchoalveolar Lavage Fluid; Humans; Mice; Molsidomine; Nitrogen Dioxide; Peroxynitrous Acid; Protein Structure, Quaternary; Protein Structure, Tertiary; Pulmonary Surfactant-Associated Protein D; Rats; Recombinant Proteins; Tandem Mass Spectrometry; Tyrosine | 2009 |
SIN-1 cytotoxicity to PC12 cells is mediated by thiol-sensitive short-lived substances generated through SIN-1 decomposition in culture medium.
Topics: Animals; Caspase 3; Cell Death; Cells, Cultured; Enzyme Inhibitors; Molsidomine; Oxidative Stress; PC12 Cells; Peroxynitrous Acid; Rats; Sulfhydryl Compounds; Superoxide Dismutase | 2009 |
Reactive nitrogen species switch on early extracellular matrix remodeling via induction of MMP1 and TNFalpha.
Topics: Actins; Animals; Apoptosis; Carbon Tetrachloride; Cell Line; Cell Proliferation; Cells, Cultured; Collagen; Collagen Type I; Collagen Type I, alpha 1 Chain; Disease Models, Animal; Extracellular Matrix; Female; Humans; Liver; Liver Cirrhosis; Matrix Metalloproteinase 1; Molsidomine; Nitric Oxide Donors; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Reactive Nitrogen Species; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 2009 |
Cytoprotective effect of lignans from Forsythia suspensa against peroxynitrite-induced LLC-PK1 cell damage.
Topics: Animals; Cytoprotection; Forsythia; Lignans; LLC-PK1 Cells; Molecular Structure; Molsidomine; Peroxynitrous Acid; Plant Extracts; Swine | 2009 |
Peroxynitrite induces gene expression in intervertebral disc cells.
Topics: Active Transport, Cell Nucleus; Adolescent; Adult; Cell Nucleus; Cells, Cultured; Female; Gene Expression; Humans; Immunohistochemistry; Interleukin-10; Interleukin-1beta; Interleukin-6; Interleukin-8; Intervertebral Disc; Intervertebral Disc Displacement; Male; Middle Aged; Molsidomine; Nitric Oxide Donors; Peroxynitrous Acid; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factor RelA; Tumor Necrosis Factor-alpha; Tyrosine | 2009 |
Chemical model systems for cellular nitros(yl)ation reactions.
Topics: Animals; Cattle; Glutathione; In Vitro Techniques; Isocitrate Dehydrogenase; Models, Chemical; Molsidomine; Nitric Oxide; Nitrosation; Peroxynitrous Acid; Phenol; Superoxide Dismutase; Swine | 2009 |
Tempol protection of spinal cord mitochondria from peroxynitrite-induced oxidative damage.
Topics: Animals; Antioxidants; Cell Respiration; Cyclic N-Oxides; Female; Mitochondria; Molsidomine; Nitric Oxide Donors; Nitroso Compounds; Oxidative Stress; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Spin Labels; Spinal Cord; Tyrosine | 2009 |
Peroxynitrite mediates muscle insulin resistance in mice via nitration of IRbeta/IRS-1 and Akt.
Topics: Animals; Dietary Fats; Gene Expression Regulation, Enzymologic; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Male; Mice; Mice, Inbred C57BL; Molsidomine; Muscle, Skeletal; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Proto-Oncogene Proteins c-akt; Receptor, Insulin; Signal Transduction | 2009 |
Arginase contributes to endothelial cell oxidative stress in response to plasma from women with preeclampsia.
Topics: Arginase; Arginine; Biopterins; Endothelial Cells; Female; Humans; Molsidomine; NADPH Oxidases; NF-kappa B; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxidative Stress; Peroxynitrous Acid; Pre-Eclampsia; Pregnancy | 2010 |
Inhibition of the soluble epoxide hydrolase by tyrosine nitration.
Topics: Animals; Cells, Cultured; Endothelial Cells; Enzyme Inhibitors; Epoxide Hydrolases; Humans; Mice; Mice, Inbred C57BL; Mice, Obese; Molsidomine; Mutagenesis, Site-Directed; Oxidative Stress; Peroxynitrous Acid; Tyrosine | 2009 |
Ethyl pyruvate inhibits peroxynitrite-induced DNA damage and hydroxyl radical generation: implications for neuroprotection.
Topics: DNA Damage; Electron Spin Resonance Spectroscopy; Hydroxyl Radical; Molsidomine; Neuroprotective Agents; Peroxynitrous Acid; Pyruvates | 2010 |
Inhibition of peroxynitrite-mediated DNA strand cleavage and hydroxyl radical formation by aspirin at pharmacologically relevant concentrations: implications for cancer intervention.
Topics: Anticarcinogenic Agents; Aspirin; Bacteriophage phi X 174; DNA Cleavage; Humans; Hydroxyl Radical; Molsidomine; Neoplasms; Peroxynitrous Acid; Plasmids | 2009 |
The role of superoxide anion in the inhibitory effect of SIN-1 in thrombin-activated human platelet adhesion.
Topics: Blood Platelets; Blood Proteins; Cell Adhesion; Enzyme Inhibitors; Fibrinogen; Free Radical Scavengers; Guanylate Cyclase; Humans; Molsidomine; Nitrates; Peroxynitrous Acid; Solubility; Superoxides; Thrombin; Tyrosine | 2010 |
Determination of glutathione, mitochondrial transmembrane potential, and cytotoxicity in H9c2 cardiomyoblasts exposed to reactive oxygen and nitrogen species.
Topics: Animals; Antioxidants; Benzimidazoles; Carbocyanines; Cell Line; Cell Survival; Fluorescent Dyes; Glutathione; Hydrazines; Membrane Potential, Mitochondrial; Mice; Molsidomine; Myocytes, Cardiac; Nitric Oxide Donors; Oxidative Stress; Peroxynitrous Acid; Reactive Nitrogen Species; Reactive Oxygen Species | 2010 |
P38 MAP kinase in valve interstitial cells is activated by angiotensin II or nitric oxide/peroxynitrite, but reduced by Toll-like receptor-2 stimulation.
Topics: Angiotensin II; Animals; Aortic Valve; Enzyme Activation; Molsidomine; Nitric Oxide; p38 Mitogen-Activated Protein Kinases; Peroxynitrous Acid; Phosphorylation; Receptors, Angiotensin; Signal Transduction; Swine; Toll-Like Receptor 2 | 2009 |
Potent inhibition of peroxynitrite-induced DNA strand breakage and hydroxyl radical formation by dimethyl sulfoxide at very low concentrations.
Topics: Cytoprotection; Dimethyl Sulfoxide; DNA Breaks; Electron Spin Resonance Spectroscopy; Free Radical Scavengers; Hydroxyl Radical; Molsidomine; Oxygen Consumption; Peroxynitrous Acid; Plasmids; Time Factors | 2010 |
Resveratrol, a dietary polyphenolic phytoalexin, is a functional scavenger of peroxynitrite.
Topics: Animals; Cell Line; Cell Survival; Epithelial Cells; Free Radical Scavengers; Kidney Tubules, Collecting; Mice; Molsidomine; Peroxynitrous Acid; Reactive Nitrogen Species; Resveratrol; Serum Albumin, Bovine; Stilbenes | 2010 |
Apoptosis of hepatic stellate cells mediated by specific protein nitration.
Topics: Animals; Apoptosis; Caspase 3; Caspase 9; Cell Line; DNA Fragmentation; Hepatic Stellate Cells; Humans; Inflammation; Intracellular Signaling Peptides and Proteins; Liver Cirrhosis; Molsidomine; Nitric Oxide; Peroxynitrous Acid; Protein-Tyrosine Kinases; Rats; Signal Transduction; src-Family Kinases; Syk Kinase; Tyrosine | 2011 |
Differential effects of NADPH oxidase and xanthine oxidase inhibition on sympathetic reinnervation in postinfarct rat hearts.
Topics: Acetophenones; Allopurinol; Animals; Arrhythmias, Cardiac; Coronary Vessels; Ethidium; Male; Molsidomine; Myocardial Infarction; Myocardium; NADPH Oxidases; Nerve Growth Factor; Oxidative Stress; Peroxynitrous Acid; Rats; Rats, Wistar; Superoxides; Sympathetic Nervous System; Tyrosine; Xanthine Oxidase | 2011 |
Detection of peroxynitrite accumulation in Arabidopsis thaliana during the hypersensitive defense response.
Topics: Aniline Compounds; Arabidopsis; Bacterial Proteins; Boron Compounds; Fluoresceins; Molsidomine; Nitric Oxide; Peroxynitrous Acid; Photometry; Plant Diseases; Plant Leaves; Protein Processing, Post-Translational; Pseudomonas syringae; Signal Transduction; Tyrosine; Uric Acid | 2011 |
Attenuated vasodilatation in lambs with endogenous and exogenous activation of cGMP signaling: role of protein kinase G nitration.
Topics: Administration, Inhalation; Animals; Animals, Newborn; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinase Type I; Cyclic GMP-Dependent Protein Kinases; Disease Models, Animal; Endothelial Cells; Enzyme Activation; Free Radical Scavengers; Hypertension, Pulmonary; Metalloporphyrins; Molsidomine; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitric Oxide; Nitric Oxide Donors; Peroxynitrous Acid; Polyethylene Glycols; Protein Processing, Post-Translational; Pulmonary Artery; Pulmonary Circulation; Second Messenger Systems; Sheep; Spermine; Superoxide Dismutase; Vasodilation; Vasodilator Agents | 2011 |
Early disruption of the actin cytoskeleton in cultured cerebellar granule neurons exposed to 3-morpholinosydnonimine-oxidative stress is linked to alterations of the cytosolic calcium concentration.
Topics: Actin Cytoskeleton; Animals; Calcium; Calcium Channel Agonists; Calcium Channels, L-Type; Cells, Cultured; Cerebellum; Molsidomine; Neurons; Nifedipine; Oxidative Stress; Peroxynitrous Acid; Pyrroles; Rats; Rats, Wistar | 2011 |
Peroxynitrite treatment reduces adenosine uptake via the equilibrative nucleoside transporter in rat astrocytes.
Topics: Adenosine; Animals; Astrocytes; Blotting, Western; Immunohistochemistry; Molsidomine; Nitric Oxide Donors; Nucleoside Transport Proteins; Oxidants; Oxidative Stress; Peroxynitrous Acid; Rats; Rats, Wistar | 2011 |
In dialyzed squid axons oxidative stress inhibits the Na+/Ca2+ exchanger by impairing the Cai2+-regulatory site.
Topics: Adenosine Triphosphate; Animals; Axons; Calcium; Chelating Agents; Decapodiformes; Dialysis; Egtazic Acid; Hydrogen Peroxide; Hydrogen-Ion Concentration; Loligo; Molsidomine; Nitric Oxide Donors; Oxidative Stress; Peroxynitrous Acid; Phenanthrolines; Sodium-Calcium Exchanger | 2011 |
Administration of a nitric oxide donor inhibits mglA expression by intracellular Francisella tularensis and counteracts phagosomal escape and subversion of TNF-α secretion.
Topics: Animals; Asialoglycoproteins; Bacterial Proteins; Blotting, Western; Cell Line; Cell Survival; Francisella tularensis; Lectins, C-Type; Macrophages; Membrane Proteins; Mice; Molsidomine; Nitric Oxide Donors; Peroxynitrous Acid; Real-Time Polymerase Chain Reaction; RNA; S-Nitroso-N-Acetylpenicillamine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tularemia; Tumor Necrosis Factor-alpha | 2011 |
Protein kinase C mediates peroxynitrite toxicity to oligodendrocytes.
Topics: Acetophenones; Animals; Benzopyrans; Carbazoles; Cells, Cultured; Chlorides; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Indoles; Isoenzymes; Maleimides; Molsidomine; Oligodendroglia; Peroxynitrous Acid; Protein Kinase C; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction; Tetradecanoylphorbol Acetate; Zinc Compounds | 2011 |
S-nitrosoglutathione reduces oxidative injury and promotes mechanisms of neurorepair following traumatic brain injury in rats.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Injuries; Brain-Derived Neurotrophic Factor; Glutathione; Intercellular Adhesion Molecule-1; Lipid Peroxidation; Male; Molsidomine; Nerve Regeneration; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Donors; Oxidative Stress; Peroxynitrous Acid; Random Allocation; Rats; Rats, Sprague-Dawley; Receptor, trkB; S-Nitrosoglutathione; Synaptophysin; Thiobarbituric Acid Reactive Substances | 2011 |
Myricetin affords protection against peroxynitrite-mediated DNA damage and hydroxyl radical formation.
Topics: Animals; Astrocytes; Bacteriophage phi X 174; Cells, Cultured; DNA Damage; DNA, Viral; Electron Spin Resonance Spectroscopy; Flavonoids; Hydroxyl Radical; Molsidomine; Oxygen; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley | 2011 |
Threshold of peroxynitrite cytotoxicity in bovine pulmonary artery endothelial and smooth muscle cells.
Topics: Animals; Apoptosis; Caspase 3; Cattle; Endothelial Cells; Endothelium, Vascular; L-Lactate Dehydrogenase; MAP Kinase Kinase 4; Molsidomine; Myocytes, Smooth Muscle; Necrosis; Nitric Oxide Donors; Oxidants; p38 Mitogen-Activated Protein Kinases; Peroxynitrous Acid; Poly(ADP-ribose) Polymerases; Pulmonary Artery | 2011 |
Tumor-infiltrating myeloid cells induce tumor cell resistance to cytotoxic T cells in mice.
Topics: Animals; Carcinoma, Lewis Lung; Cell Line, Tumor; Female; Humans; Inflammation Mediators; Interleukin-1beta; Lymphocytes, Tumor-Infiltrating; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Molsidomine; Myeloid Cells; Neoplasms, Experimental; Peroxynitrous Acid; T-Lymphocytes, Cytotoxic; Tumor Escape | 2011 |
The peroxynitrite donor 3-morpholinosydnonimine activates Nrf2 and the UPR leading to a cytoprotective response in endothelial cells.
Topics: Autophagy; Cell Line; Cell Nucleus; Cell Survival; Cytoprotection; DNA Fragmentation; Endothelial Cells; Gene Expression Profiling; Gene Expression Regulation; Heme Oxygenase-1; Humans; Molsidomine; NAD(P)H Dehydrogenase (Quinone); NF-E2-Related Factor 2; Oxidants; Peroxynitrous Acid; Protein Transport; RNA Interference; Signal Transduction; Transcription Factor CHOP; Transcription, Genetic; Unfolded Protein Response | 2012 |
Conformational altered p53 as an early marker of oxidative stress in Alzheimer's disease.
Topics: Adult; Age of Onset; Alzheimer Disease; Biomarkers; Case-Control Studies; Demography; Female; Glutathione Peroxidase; Glutathione Reductase; Humans; Lymphocytes; Male; Middle Aged; Molsidomine; Mutation; Nitrosation; Oxidation-Reduction; Oxidative Stress; Peroxynitrous Acid; Protein Conformation; Protein Unfolding; Superoxide Dismutase; Tumor Suppressor Protein p53 | 2012 |
Effects of maté tea intake on ex vivo LDL peroxidation induced by three different pathways.
Topics: Antioxidants; Beverages; Cholesterol, LDL; Copper Sulfate; Female; Humans; Ilex paraguariensis; Lipoxygenase; Molsidomine; Peroxynitrous Acid; Plant Leaves; Plant Preparations | 2009 |
Protein kinase CK2 mediates peroxynitrite-induced heme oxygenase-1 expression in articular chondrocytes.
Topics: Animals; Apoptosis; Cartilage, Articular; Casein Kinase II; Cells, Cultured; Chondrocytes; Enzyme Induction; Female; Heme Oxygenase-1; Molsidomine; NF-E2-Related Factor 2; Peroxynitrous Acid; Phosphorylation; Rats; Rats, Sprague-Dawley | 2012 |
Peroxynitrite has potent pulmonary vasodilator activity in the rat.
Topics: Animals; Dose-Response Relationship, Drug; Male; Molsidomine; Nitric Oxide Donors; Nitroprusside; Oxadiazoles; Penicillamine; Peroxynitrous Acid; Pulmonary Artery; Quinoxalines; Rats; Rats, Sprague-Dawley; Vasodilation; Vasodilator Agents | 2012 |
(13Z)- and (9Z)-lycopene isomers are major intermediates in the oxidative degradation of lycopene by cigarette smoke and Sin-1.
Topics: Adolescent; Adult; Antioxidants; Carotenoids; Chromatography, High Pressure Liquid; Humans; Lipoproteins, LDL; Lycopene; Middle Aged; Molsidomine; Nicotiana; Oxidation-Reduction; Peroxynitrous Acid; Reactive Oxygen Species; Smoke; Solutions; Stereoisomerism | 2012 |
Peroxynitrite donor SIN-1 alters high-affinity choline transporter activity by modifying its intracellular trafficking.
Topics: Cell Line, Transformed; Cell Line, Tumor; Choline; Clathrin; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Endocytosis; Endosomes; Hemicholinium 3; Humans; Leupeptins; Luminescent Proteins; Lysosomes; Membrane Transport Proteins; Molsidomine; Mutation; Neuroblastoma; Nitric Oxide; Nitric Oxide Donors; Peroxynitrous Acid; Protein Transport; rab5 GTP-Binding Proteins; Time Factors; Transfection; Tritium; Ubiquitination | 2012 |
Evaluation of novel antioxidant triterpenoid saponins from the halophyte Salicornia herbacea.
Topics: Antioxidants; Chenopodiaceae; Molecular Conformation; Molsidomine; Peroxynitrous Acid; Salt-Tolerant Plants; Saponins; Triterpenes | 2012 |
Protection against peroxynitrite by pseudoperoxidase from Leishmania major.
Topics: Amino Acid Sequence; Animals; Cell Line; Cell Membrane; Female; Hydrogen Peroxide; Leishmania major; Leishmaniasis, Cutaneous; Macrophage Activation; Macrophages; Membrane Proteins; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Molsidomine; Peroxidase; Peroxynitrous Acid; Protozoan Proteins | 2012 |
[Effects of peroxynitrite derived from nitric oxide on cultured bovine ocular explants].
Topics: Animals; Cattle; Cells, Cultured; Drug Evaluation, Preclinical; Eye; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Organ Culture Techniques; Oxidants; Peroxynitrous Acid | 2013 |
Neuroprotective effects of Cyperus rotundus on SIN-1 induced nitric oxide generation and protein nitration: ameliorative effect against apoptosis mediated neuronal cell damage.
Topics: Apoptosis; Blotting, Western; Caspase 3; Catalase; Cell Death; Cell Line, Tumor; Cyperus; Cytoprotection; DNA Damage; Dose-Response Relationship, Drug; HSP70 Heat-Shock Proteins; Humans; Lipid Peroxidation; Molsidomine; Neurons; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Plant Extracts; Plants, Medicinal; Proto-Oncogene Proteins c-bcl-2; Rhizome; Superoxide Dismutase; Tyrosine | 2013 |
Impact of SIN-1-derived peroxynitrite flux on endothelial cell redox homeostasis and bioenergetics: protective role of diphenyl diselenide via induction of peroxiredoxins.
Topics: Animals; Aorta; Benzene Derivatives; Cattle; Endothelial Cells; Energy Metabolism; Homeostasis; Membrane Potential, Mitochondrial; Mitochondria; Molsidomine; Organoselenium Compounds; Oxidation-Reduction; Peroxiredoxins; Peroxynitrous Acid | 2015 |
Peroxynitrite-mediated nitrosative stress decreases motility and mitochondrial membrane potential in human spermatozoa.
Topics: Adult; Benzimidazoles; Carbocyanines; Cell Survival; Fluorescent Dyes; Humans; Male; Membrane Potential, Mitochondrial; Molsidomine; Oxidative Stress; Peroxynitrous Acid; Rhodamines; Semen Analysis; Spectrometry, Fluorescence; Sperm Motility; Spermatozoa | 2015 |
Interaction between hydrogen sulfide-induced sulfhydration and tyrosine nitration in the KATP channel complex.
Topics: Animals; Calcium Chloride; CHO Cells; Cricetulus; Cysteine; Dose-Response Relationship, Drug; Ileum; KATP Channels; Mice; Molsidomine; Muscle Contraction; Muscle, Smooth; Mutation; Peroxynitrous Acid; Protein Processing, Post-Translational; Signal Transduction; Sulfides; Sulfonylurea Receptors; Transfection; Tyrosine | 2015 |
Myeloperoxidase scavenges peroxynitrite: A novel anti-inflammatory action of the heme enzyme.
Topics: Aniline Compounds; Anti-Inflammatory Agents; Catechin; Fluoresceins; Halogenation; Humans; Hydrogen Peroxide; Hydrogen-Ion Concentration; Kinetics; Molsidomine; Nitrites; Oxidants; Oxidation-Reduction; Peroxidase; Peroxynitrous Acid; Tyrosine | 2015 |
Nitrosative stress by peroxynitrite impairs ATP production in human spermatozoa.
Topics: Adenosine Triphosphate; Antimetabolites; Deoxyglucose; Glycolysis; Humans; Male; Membrane Potential, Mitochondrial; Mitochondria; Molsidomine; Oxidative Phosphorylation; Oxidative Stress; Peroxynitrous Acid; Rotenone; Sperm Motility; Spermatozoa; Uncoupling Agents | 2017 |
Thiol oxidation by nitrosative stress: Cellular localization in human spermatozoa.
Topics: Fluorescent Dyes; Humans; Male; Molsidomine; Oxidation-Reduction; Peroxynitrous Acid; Semen Analysis; Sperm Motility; Spermatozoa; Sulfhydryl Compounds | 2016 |
Triosephosphate isomerase tyrosine nitration induced by heme-NaNO
Topics: Acetophenones; Anthracenes; Antioxidants; Circular Dichroism; Flavonoids; Heme; Hydrogen Peroxide; Indicators and Reagents; Kinetics; Molsidomine; Oxidants; Oxidation-Reduction; Peroxynitrous Acid; Phytochemicals; Protein Processing, Post-Translational; Protein Structure, Secondary; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sodium Nitrite; Triose-Phosphate Isomerase; Tyrosine | 2017 |
Reactive nitrogen species control apoptosis and autophagy in K562 cells: implication of TAp73α induction in controlling autophagy.
Topics: Apoptosis; Autophagy; Humans; K562 Cells; Molsidomine; Nitroso Compounds; Peroxynitrous Acid; Reactive Nitrogen Species; Tumor Protein p73 | 2018 |
Imaging and Quantification of Secreted Peroxynitrite at the Cell Surface by a Streptavidin-Biotin-Controlled Binding Probe.
Topics: Animals; Biotin; Carbocyanines; Cell Membrane; Enzyme Activators; Fluorescent Dyes; Gene Expression; Interferon-gamma; Lipopolysaccharides; Mice; Microscopy, Confocal; Microscopy, Fluorescence; Molsidomine; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Phosphatidylinositol 4,5-Diphosphate; RAW 264.7 Cells; Streptavidin; Tetradecanoylphorbol Acetate | 2018 |
Force generated by myosin cross-bridges is reduced in myofibrils exposed to ROS/RNS.
Topics: Actins; Animals; Isometric Contraction; Molsidomine; Myofibrils; Myosins; Nitric Oxide Donors; Oxidants; Oxidative Stress; Peroxynitrous Acid; Psoas Muscles; Rabbits; Tissue Culture Techniques | 2019 |
Peroxynitrite-Induced Intracellular Ca2+ Depression in Cardiac Myocytes: Role of Sarco/Endoplasmic Reticulum Ca2+ Pump.
Topics: Animals; Caffeine; Calcium; Endoplasmic Reticulum; Intracellular Space; Male; Membrane Transport Proteins; Molsidomine; Myocardial Contraction; Myocytes, Cardiac; Peroxynitrous Acid; Phosphorylation; Rats, Wistar; Tetracaine | 2019 |
Red Blood Cell Peroxynitrite Causes Endothelial Dysfunction in Type 2 Diabetes Mellitus via Arginase.
Topics: Animals; Aorta; Arginase; Diabetes Mellitus, Type 2; Endothelium, Vascular; Erythrocytes; Female; Humans; Male; Middle Aged; Models, Biological; Molsidomine; Peroxynitrous Acid; Rats, Sprague-Dawley; Rats, Wistar | 2020 |
Peroxynitrite decomposition catalyst enhances respiratory function in isolated brain mitochondria.
Topics: Animals; Brain; Catalysis; Cell Respiration; Membrane Potential, Mitochondrial; Metalloporphyrins; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; Molsidomine; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Peroxynitrous Acid; Reactive Oxygen Species; Superoxides | 2021 |