Compounds > peroxynitrous acid
Page last updated: 2024-09-03

peroxynitrous acid and indomethacin

peroxynitrous acid has been researched along with indomethacin in 4 studies

Compound Research Comparison

Studies
(peroxynitrous acid)		Trials
(peroxynitrous acid)		Recent Studies (post-2010)
(peroxynitrous acid)		Studies
(indomethacin)		Trials
(indomethacin)		Recent Studies (post-2010) (indomethacin)
3,303211,23029,5271,8383,396

Protein Interaction Comparison

ProteinTaxonomyperoxynitrous acid (IC50)indomethacin (IC50)
Chain A, membrane-associated prostaglandin E synthase-2Macaca fascicularis (crab-eating macaque)1000
Prostaglandin-H2 D-isomeraseMus musculus (house mouse)1.1
Multidrug resistance-associated protein 4Homo sapiens (human)5.8
Prostaglandin G/H synthase 1 Bos taurus (cattle)0.9994
Prostaglandin G/H synthase 2 Bos taurus (cattle)0.7764
Cytochrome c oxidase subunit 2Homo sapiens (human)0.34
Prostaglandin G/H synthase 1Ovis aries (sheep)0.5605
Neuronal acetylcholine receptor subunit alpha-4Rattus norvegicus (Norway rat)0.004
Interleukin-8Homo sapiens (human)0.05
Neuronal acetylcholine receptor subunit beta-2Rattus norvegicus (Norway rat)0.004
Aldo-keto reductase family 1 member B1Homo sapiens (human)6
Aldo-keto reductase family 1 member B1Bos taurus (cattle)5
Prostaglandin G/H synthase 1Mus musculus (house mouse)0.011
Prostaglandin G/H synthase 1Homo sapiens (human)0.4848
Sodium- and chloride-dependent GABA transporter 1Rattus norvegicus (Norway rat)0.2
Thromboxane-A synthase Homo sapiens (human)0.1
Indoleamine 2,3-dioxygenase 1Mus musculus (house mouse)0.082
Nitric oxide synthase, inducibleMus musculus (house mouse)4.5
Substance-P receptorCavia porcellus (domestic guinea pig)5.7
Sodium- and chloride-dependent GABA transporter 2Rattus norvegicus (Norway rat)0.2
Sodium- and chloride-dependent GABA transporter 3Rattus norvegicus (Norway rat)0.2
Prostaglandin G/H synthase 2Homo sapiens (human)1.5128
Prostaglandin G/H synthase 2 Rattus norvegicus (Norway rat)0.5504
Aldo-keto reductase family 1 member C3Homo sapiens (human)3.4486
Sodium- and chloride-dependent betaine transporterRattus norvegicus (Norway rat)0.2
C-X-C chemokine receptor type 3Homo sapiens (human)0.05
Aldo-keto reductase family 1 member C2 Homo sapiens (human)8.97
Prostaglandin G/H synthase 2Ovis aries (sheep)3.4647
Prostaglandin G/H synthase 2Mus musculus (house mouse)0.4233
Solute carrier family 22 member 6Homo sapiens (human)3
Sigma intracellular receptor 2Rattus norvegicus (Norway rat)0.49
Rho-associated protein kinase 2Rattus norvegicus (Norway rat)7.7
Prostaglandin G/H synthase 1 Rattus norvegicus (Norway rat)0.5461
P2Y purinoceptor 12Rattus norvegicus (Norway rat)0.96

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (75.00)29.6817
2010's1 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Dansette, PM; Fontana, E; Poli, SM1
Bubolz, AH; Gutterman, DD; Liu, Y; Newman, DK; Newman, PJ; Shi, Y1
Cuzzocrea, S; Di Paola, R; Esposito, E; Matuschak, GM; Mazzon, E; Ndengele, MM; Salvemini, D1
Bachri, MS; Choi, J; Choi, JS; Kim, WB; Lee, BI; Lee, JD; Lee, KR; Lee, KT; Nugroho, A; Park, HJ1

Reviews

1 review(s) available for peroxynitrous acid and indomethacin

ArticleYear
Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.
    Current drug metabolism, 2005, Volume: 6, Issue:5

    Topics: Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; Isoenzymes; Structure-Activity Relationship; Terminology as Topic

2005

Other Studies

3 other study(ies) available for peroxynitrous acid and indomethacin

ArticleYear
Peroxynitrite reduces the endothelium-derived hyperpolarizing factor component of coronary flow-mediated dilation in PECAM-1-knockout mice.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2006, Volume: 290, Issue:1

    Topics: Animals; Azoles; Biological Factors; Coronary Vessels; Gene Deletion; Hydrogen Peroxide; Indomethacin; Isoindoles; Male; Mice; Mice, Knockout; NG-Nitroarginine Methyl Ester; Nitric Oxide; Organoselenium Compounds; Peroxynitrous Acid; Platelet Endothelial Cell Adhesion Molecule-1; Prostaglandins; Tyrosine; Vasodilation

2006
Cyclooxygenases 1 and 2 contribute to peroxynitrite-mediated inflammatory pain hypersensitivity.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2008, Volume: 22, Issue:9

    Topics: Animals; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Drug Synergism; Edema; Hot Temperature; Hyperalgesia; Indomethacin; Male; Metalloporphyrins; NF-kappa B; Nitrobenzenes; Pain; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Sulfonamides

2008
Anti-ulcerogenic effect and HPLC analysis of the caffeoylquinic acid-rich extract from Ligularia stenocephala.
    Biological & pharmaceutical bulletin, 2010, Volume: 33, Issue:3

    Topics: Animals; Anti-Ulcer Agents; Asteraceae; Bethanechol; Chromatography, High Pressure Liquid; Ethanol; Gastric Juice; Hydrochloric Acid; Indomethacin; Male; Mice; Mice, Inbred ICR; Peroxynitrous Acid; Plant Extracts; Plant Leaves; Quinic Acid; Species Specificity; Stomach Ulcer

2010