Page last updated: 2024-09-03

peroxynitrous acid and cyclic gmp

peroxynitrous acid has been researched along with cyclic gmp in 50 studies

Compound Research Comparison

Studies (peroxynitrous acid)	Trials (peroxynitrous acid)	Recent Studies (post-2010) (peroxynitrous acid)	Studies (cyclic gmp)	Trials (cyclic gmp)	Recent Studies (post-2010) (cyclic gmp)
3,303	21	1,230	22,346	333	4,062

Protein Interaction Comparison

Protein	Taxonomy	cyclic gmp (IC50)
Phosphodiesterase	Bos taurus (cattle)	0.1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Homo sapiens (human)	2.4
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	Homo sapiens (human)	2.4

Research

Studies (50)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	36 (72.00)	29.6817
2010's	13 (26.00)	24.3611
2020's	1 (2.00)	2.80

Authors

Authors	Studies
Hara, A; Higo, A; Katsura, M; Ohgi, T; Ohkuma, S; Shirotani, K; Tarumi, C	1
Haramaki, N; Ikeda, H; Imaizumi, T; Murohara, T; Takajo, Y	1
Cohen, RA; Shi, C; Zou, MH	1
Bruckdorfer, KR; Low, SY; Naseem, KM; Sabetkar, M	1
Barrett, KE; Resta-Lenert, S	1
Du, Y; Kern, TS; Miller, CM; Smith, MA	1
Cohen, RA; Hou, XY; Nagata, D; Shi, CM; Walsh, K; Zou, MH	1
Coupland, K; Daniels, I; Long, RG; Murray, IA; Smith, JA	1
Almeida, A; Delgado-Esteban, M; Medina, JM	1
Chan, JY; Chan, SH; Ou, CC; Wang, LL	1
Graier, WF; Groschner, K; Malli, R; Schmidt, K; Thyagarajan, B	1
Befus, AD; Forsythe, P	1
Jordán, J; Llorens, S; Nava, E	1
Caroni, P; Drexler, H; Heineke, J; Hilfiker, A; Kempf, T; Kraft, T; Lohmann, SM; Morawietz, H; Scheubel, RJ; Wollert, KC	1
Alloatti, G; Bedendi, I; Gallo, MP; Levi, RC; Malan, D; Marcantoni, A	1
Abou-Mohamed, G; Caldwell, RB; Caldwell, RW; Do, K; El-Remessy, AB; Jin, L; Johnson, JA; Kaesemeyer, WH	1
Brunner, F; Wölkart, G	1
Chan, JY; Chan, SH; Chang, AY	1
Gorren, AC; Mayer, B; Rehn, M; Schmidt, K; Wippel, R	1
Cassano, T; Cuomo, V; Kendrick, KM; Steardo, L; Trabace, L; Tucci, P	1
Ambrósio, AF; Araújo, IM; Carvalho, CM; Verdasca, MJ	1
Behr-Roussel, D; Kumar H S, A; Melichar, VO; Rodrigo, J; Rupin, A; Schmidt, HH; Uttenthal, LO; Verbeuren, TJ; Zabel, U	1
Figueroa, S; González, MP; Oset-Gasque, MJ; Pérez-Rodríguez, R; Vicente, S	1
Chan, JY; Chan, SH; Chang, AY; Cheng, HL; Li, FC; Tsai, CY	1
Kennedy, RH; Liu, MY; Liu, SJ; Yu, XW	1
Bel-Hadj, S; Calderone, A; Clement, R; Drapeau, J; El-Helou, V; Gosselin, H	1
Doke, N; Kawakita, K; Saito, S; Yamamoto-Katou, A; Yoshioka, H	1
Delamere, NA; Shahidullah, M	1
Boor, PJ; Chu, ET; Dwivedi, S; Fitchett, K; Li, J; Wang, L; Xu, Y; Yang, Y	1
Brown, LA; Hart, CM; Polikandriotis, JA; Rupnow, HL	1
Kagota, S; Kubota, Y; Kunitomo, M; Nakamura, K; Nejime, N; Shinozuka, K; Tada, Y; Yamaguchi, Y	1
Huang, J; Lin, SC; Nadershahi, A; Sarkar, R; Watts, SW	1
Beck, FX; Fraek, ML; Neuhofer, W	1
Dong, DL; Wang, WH; Yang, BF; Yue, P	1
Arif, R; Barnucz, E; Hirschberg, K; Karck, M; Korkmaz, S; Loganathan, S; Neugebauer, P; Radovits, T; Seidel, B; Szabó, G	1
Barnucz, E; Hirschberg, K; Karck, M; Korkmaz, S; Loganathan, S; Neugebauer, P; Páli, S; Radovits, T; Seidel, B; Szabó, G; Veres, G; Zöllner, S	1
Song, P; Xu, J; Zhang, M; Zou, MH	1
Aggarwal, S; Black, SM; Datar, S; Fineman, JR; Fratz, S; Gross, CM; Kalkan, G; Kumar, S; Oishi, P; Schreiber, C	1
Caballero, S; Grant, MB; Jarajapu, YP; Li, Q; Lo, MC; Nakagawa, T; Verma, A	1
Ahmed, KA; Akaike, T; Fujii, S; Ihara, H; Kasamatsu, S; Okamoto, T; Rahaman, MM; Sawa, T; Yoshitake, J	1
Thurmond, DC; Wiseman, DA	1
Gorren, AC; Kolesnik, B; Mayer, B; Neubauer, A; Schmidt, K; Stasch, JP; Werner, ER	1
Barnucz, E; Hegedüs, P; Hirschberg, K; Karck, M; Korkmaz, S; Li, S; Loganathan, S; Mikles, B; Páli, S; Radovits, T; Szabó, G; Weymann, A	1
Black, S; El-Remessy, AB; Ergul, A; Johnson, M; Kumar, S; Owen, MP; Puttabyatappa, Y; Stallone, JN; White, RE	1
Aggarwal, S; Black, SM; Fineman, JR; Gross, CM; Jonigk, D; Kumar, S; Ludewig, B; Rafikov, R	1
Imamura, T; Iwasaki, H; Okamura, T; Shimosato, T; Tawa, M	1
Schmidtko, A	1
Cai, ZX; Chen, YW; Cheng, C; Guo, HS; Le, WD; Li, S; Wang, C; Wei, M; Yang, ZF	1
Barkhuizen, M; Blanco, CE; De Vente, J; Gavilanes, AW; Steinbusch, HW; Van de Berg, WD	1
Chan, YC; Chang, CH; Chu, YS; Fan, CS; Hsu, JW; Wu, CL	1

Reviews

3 review(s) available for peroxynitrous acid and cyclic gmp

Article	Year
The nitric oxide pathway in the cardiovascular system. Journal of physiology and biochemistry, 2002, Volume: 58, Issue:3 Topics: Animals; Arginine; Cardiovascular System; Cyclic GMP; Guanylate Cyclase; Humans; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Peroxynitrous Acid	2002
The good and bad effects of cysteine S-nitrosylation and tyrosine nitration upon insulin exocytosis: a balancing act. Current diabetes reviews, 2012, Jul-01, Volume: 8, Issue:4 Topics: Apoptosis; Cyclic GMP; Cysteine; Diabetes Mellitus; Exocytosis; Female; Humans; Insulin-Secreting Cells; Male; Nitric Oxide; Oxidation-Reduction; Peroxynitrous Acid; Protein Processing, Post-Translational; Signal Transduction; Tyrosine	2012
Nitric oxide-mediated pain processing in the spinal cord. Handbook of experimental pharmacology, 2015, Volume: 227 Topics: Animals; Cyclic GMP; Humans; Nitric Oxide; Pain; Peroxynitrous Acid; Signal Transduction; Spinal Cord	2015

Other Studies

47 other study(ies) available for peroxynitrous acid and cyclic gmp

Article	Year
Peroxynitrite affects Ca2+ influx through voltage-dependent calcium channels. Journal of neurochemistry, 2001, Volume: 76, Issue:2 Topics: Anesthetics, Local; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Radioisotopes; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Fluorescent Dyes; Free Radical Scavengers; Ion Transport; Mice; Mice, Inbred Strains; Neurons; Peroxynitrous Acid; Potassium Chloride; Tetrodotoxin; Thiobarbiturates	2001
Augmented oxidative stress of platelets in chronic smokers. Mechanisms of impaired platelet-derived nitric oxide bioactivity and augmented platelet aggregability. Journal of the American College of Cardiology, 2001, Nov-01, Volume: 38, Issue:5 Topics: Administration, Oral; Adult; Antioxidants; Ascorbic Acid; Biological Availability; Blood Platelets; Case-Control Studies; Chronic Disease; Cyclic GMP; Free Radical Scavengers; Glutathione; Humans; Male; Nitric Oxide; Oxidation-Reduction; Oxidative Stress; Peroxynitrous Acid; Platelet Aggregation; Smoking; Time Factors; Tyrosine	2001
High glucose via peroxynitrite causes tyrosine nitration and inactivation of prostacyclin synthase that is associated with thromboxane/prostaglandin H(2) receptor-mediated apoptosis and adhesion molecule expression in cultured human aortic endothelial cel Diabetes, 2002, Volume: 51, Issue:1 Topics: Aorta; Apoptosis; Cell Adhesion Molecules; Cells, Cultured; Cyclic GMP; DNA Fragmentation; Endothelium, Vascular; Glucose; Humans; Nitrates; Peroxynitrous Acid; Prostaglandin-Endoperoxide Synthases; Receptors, Prostaglandin; Receptors, Thromboxane A2, Prostaglandin H2; Superoxides; Tyrosine	2002
The role of protein nitration in the inhibition of platelet activation by peroxynitrite. FEBS letters, 2002, Jan-30, Volume: 511, Issue:1-3 Topics: Blood Platelets; Cyclic GMP; Dose-Response Relationship, Drug; Humans; Nitrates; Nitric Oxide; Peroxynitrous Acid; Phosphorylation; Platelet Activation; Platelet Aggregation; Proteins; Signal Transduction; Thrombin; Time Factors; Tyrosine	2002
Enteroinvasive bacteria alter barrier and transport properties of human intestinal epithelium: role of iNOS and COX-2. Gastroenterology, 2002, Volume: 122, Issue:4 Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Biological Transport; Caco-2 Cells; Chlorides; Cyclic AMP; Cyclic GMP; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cystic Fibrosis Transmembrane Conductance Regulator; Diarrhea; Dinoprostone; Electric Impedance; Enzyme Inhibitors; Epithelial Cells; Escherichia coli Infections; Gene Expression Regulation, Enzymologic; Guanylate Cyclase; HT29 Cells; Humans; Intestinal Mucosa; Isoenzymes; Membrane Proteins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrobenzenes; Peroxynitrous Acid; Prostaglandin-Endoperoxide Synthases; Salmonella Infections; Sodium-Potassium-Chloride Symporters; Solute Carrier Family 12, Member 2; Sulfonamides; Up-Regulation; Water-Electrolyte Balance	2002
Diabetes-induced nitrative stress in the retina, and correction by aminoguanidine. Journal of neurochemistry, 2002, Volume: 80, Issue:5 Topics: Animals; Cattle; Cells, Cultured; Cyclic GMP; Diabetes Complications; Diabetes Mellitus; Diabetic Retinopathy; Endothelium, Vascular; Glucose; Guanidines; Hyperglycemia; Immunohistochemistry; Male; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidative Stress; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Retina; Streptozocin; Tyrosine	2002
Modulation by peroxynitrite of Akt- and AMP-activated kinase-dependent Ser1179 phosphorylation of endothelial nitric oxide synthase. The Journal of biological chemistry, 2002, Sep-06, Volume: 277, Issue:36 Topics: Adenoviridae; AMP-Activated Protein Kinases; Animals; Arginine; Blotting, Western; Cattle; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; Enzyme Activation; Genes, Dominant; Multienzyme Complexes; Mutation; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxygen; Peroxynitrous Acid; Phosphorylation; Precipitin Tests; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Serine; Time Factors; Transfection; Up-Regulation; Zinc	2002
Increased activity and expression of iNOS in human duodenal enterocytes from patients with celiac disease. American journal of physiology. Gastrointestinal and liver physiology, 2002, Volume: 283, Issue:2 Topics: Blotting, Western; Celiac Disease; Cyclic GMP; Duodenum; Enterocytes; Humans; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Peroxynitrous Acid	2002
Tetrahydrobiopterin deficiency increases neuronal vulnerability to hypoxia. Journal of neurochemistry, 2002, Volume: 82, Issue:5 Topics: Adenosine Triphosphate; Animals; Antioxidants; Biopterins; Cell Death; Cell Hypoxia; Cells, Cultured; Cyclic GMP; Enzyme Inhibitors; GTP Cyclohydrolase; Hypoxanthines; Hypoxia, Brain; Mitochondria; Neurons; Nitric Oxide Synthase; Oxidative Stress; Peroxynitrous Acid; Rats; Rats, Wistar	2002
Contribution of peroxynitrite to fatal cardiovascular depression induced by overproduction of nitric oxide in rostral ventrolateral medulla of the rat. Neuropharmacology, 2002, Volume: 43, Issue:5 Topics: Animals; Blotting, Western; Cardiovascular Diseases; Cyclic GMP; Depression, Chemical; Guanylate Cyclase; Hemodynamics; Male; Medulla Oblongata; Microinjections; Muscle Tonus; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Survival Analysis; Time Factors	2002
Nitric oxide inhibits capacitative Ca2+ entry by suppression of mitochondrial Ca2+ handling. British journal of pharmacology, 2002, Volume: 137, Issue:6 Topics: Barium; Calcium; Cell Line; Cyclic GMP; Diethylamines; Dose-Response Relationship, Drug; Humans; Intracellular Membranes; Membrane Potentials; Mitochondria; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; Oxadiazoles; Oxygen Consumption; Peroxynitrous Acid; Quinoxalines; Thapsigargin; Time Factors	2002
Inhibition of calpain is a component of nitric oxide-induced down-regulation of human mast cell adhesion. Journal of immunology (Baltimore, Md. : 1950), 2003, Jan-01, Volume: 170, Issue:1 Topics: Calpain; Cell Adhesion; Cyclic GMP; Dipeptides; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Fibronectins; Humans; Leupeptins; Mast Cells; Nitric Oxide; Nitric Oxide Donors; Peroxynitrous Acid; Protein Binding; S-Nitroso-N-Acetylpenicillamine; S-Nitrosoglutathione; Tumor Cells, Cultured	2003
Downregulation of cytoskeletal muscle LIM protein by nitric oxide: impact on cardiac myocyte hypertrophy. Circulation, 2003, Mar-18, Volume: 107, Issue:10 Topics: Animals; Cell Size; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinase Type I; Cyclic GMP-Dependent Protein Kinases; Cytokines; Cytoskeletal Proteins; Down-Regulation; Endothelin-1; Gene Expression Regulation; Heart Failure; Humans; LIM Domain Proteins; Muscle Proteins; Myocytes, Cardiac; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oligonucleotides, Antisense; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Sarcomeres; Superoxides	2003
Cyclic AMP and cyclic GMP independent stimulation of ventricular calcium current by peroxynitrite donors in guinea pig myocytes. Journal of cellular physiology, 2003, Volume: 197, Issue:2 Topics: Animals; Calcium; Calcium Channels; Calcium Signaling; Cyclic AMP; Cyclic GMP; Guinea Pigs; Heart Ventricles; Metalloporphyrins; Molsidomine; Myocytes, Cardiac; Nitric Oxide; Nitric Oxide Donors; Peroxynitrous Acid; Pyrogallol; Superoxide Dismutase; Up-Regulation	2003
Roles of superoxide, peroxynitrite, and protein kinase C in the development of tolerance to nitroglycerin. The Journal of pharmacology and experimental therapeutics, 2004, Volume: 308, Issue:1 Topics: Animals; Cattle; Cells, Cultured; Cyclic GMP; Drug Tolerance; Enzyme Activation; Nitroglycerin; Peroxynitrous Acid; Protein Kinase C; Rats; Rats, Sprague-Dawley; Superoxides	2004
Peroxynitrite-induced cardiac depression: role of myofilament desensitization and cGMP pathway. Cardiovascular research, 2003, Nov-01, Volume: 60, Issue:2 Topics: 1-Methyl-3-isobutylxanthine; Amiloride; Animals; Calcium; Calcium Channel Blockers; Cyclic GMP; Enzyme Inhibitors; Female; Homeostasis; Male; Myocardial Contraction; Myocardium; Nicardipine; Oxidants; Perfusion; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Sodium-Potassium-Exchanging ATPase	2003
Contribution of cGMP but not peroxynitrite to negative feedback regulation of penile erection elicited by nitric oxide in the hippocampal formation of the rat. Neuropharmacology, 2004, Volume: 46, Issue:1 Topics: Aminoquinolines; Animals; Cyclic GMP; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Activators; Enzyme Inhibitors; Feedback; Hippocampus; Indazoles; Male; Microinjections; Nitric Oxide; Penile Erection; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Venous Pressure	2004
Interference of the polyphenol epicatechin with the biological chemistry of nitric oxide- and peroxynitrite-mediated reactions. Biochemical pharmacology, 2004, Apr-01, Volume: 67, Issue:7 Topics: Catechin; Cyclic GMP; Flavonoids; HL-60 Cells; Humans; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidation-Reduction; Peroxynitrous Acid; Phenols; Polyphenols; Signal Transduction; Tyrosine	2004
The effects of nitric oxide on striatal serotoninergic transmission involve multiple targets: an in vivo microdialysis study in the awake rat. Brain research, 2004, May-22, Volume: 1008, Issue:2 Topics: Animals; Cyclic GMP; Enzyme Inhibitors; Free Radical Scavengers; Guanylate Cyclase; Male; Microdialysis; N-Methylaspartate; Neostriatum; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Peroxynitrous Acid; Rats; Rats, Wistar; Serotonin; Signal Transduction; Superoxides; Synaptic Transmission	2004
Nitric oxide inhibits complex I following AMPA receptor activation via peroxynitrite. Neuroreport, 2004, Sep-15, Volume: 15, Issue:13 Topics: Analysis of Variance; Animals; Antihypertensive Agents; Benzothiadiazines; Cells, Cultured; Cyclic GMP; Drug Interactions; Embryo, Mammalian; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; Immunohistochemistry; Kainic Acid; Microtubule-Associated Proteins; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Peroxynitrous Acid; Proton Pumps; Quinoxalines; Rats; Receptors, AMPA; Tyrosine	2004
Reduced cGMP signaling associated with neointimal proliferation and vascular dysfunction in late-stage atherosclerosis. Proceedings of the National Academy of Sciences of the United States of America, 2004, Nov-23, Volume: 101, Issue:47 Topics: Animals; Aorta, Thoracic; Arteriosclerosis; Cell Adhesion Molecules; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Guanylate Cyclase; Lipids; Microfilament Proteins; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Phosphoproteins; Phosphoric Diester Hydrolases; Phosphorylation; Rabbits; Signal Transduction; Superoxide Dismutase	2004
Nitric oxide donors induce calcium-mobilisation from internal stores but do not stimulate catecholamine secretion by bovine chromaffin cells in resting conditions. Cell calcium, 2005, Volume: 37, Issue:2 Topics: Animals; Calcium; Calcium Channels; Calcium Channels, N-Type; Catecholamines; Cattle; Chromaffin Cells; Cyclic GMP; Inositol 1,4,5-Trisphosphate Receptors; Nitric Oxide; Nitric Oxide Donors; Peroxynitrous Acid; Receptors, Cytoplasmic and Nuclear	2005
Phasic cardiovascular responses to mevinphos are mediated through differential activation of cGMP/PKG cascade and peroxynitrite via nitric oxide generated in the rat rostral ventrolateral medulla by NOS I and II isoforms. Neuropharmacology, 2005, Volume: 48, Issue:1 Topics: Animals; Blood Pressure; Blotting, Western; Cardiovascular Physiological Phenomena; Cholinesterase Inhibitors; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Heart Rate; Male; Medulla Oblongata; Mevinphos; Microinjections; Nerve Tissue Proteins; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Rats; Spectrum Analysis; Superoxides; Time Factors; Tyrosine	2005
Both cGMP and peroxynitrite mediate chronic interleukin-6-induced negative inotropy in adult rat ventricular myocytes. The Journal of physiology, 2005, Jul-15, Volume: 566, Issue:Pt 2 Topics: Animals; Cell Separation; Cyclic GMP; Depression, Chemical; Guanylate Cyclase; Interleukin-6; Male; Myocardial Contraction; Myocytes, Cardiac; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Sarcoplasmic Reticulum; Signal Transduction; Stimulation, Chemical; Superoxides	2005
Nitric oxide-mediated inhibition of DNA synthesis was attenuated in hypertrophied neonatal rat ventricular myocytes. Nitric oxide : biology and chemistry, 2006, Volume: 14, Issue:4 Topics: Animals; Animals, Newborn; Cyclic GMP; DNA; Heart Ventricles; Hypertrophy; Hypertrophy, Left Ventricular; Mitogen-Activated Protein Kinases; Muscle Cells; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; p38 Mitogen-Activated Protein Kinases; Penicillamine; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Ventricular Myosins	2006
Peroxynitrite generation and tyrosine nitration in defense responses in tobacco BY-2 cells. Plant & cell physiology, 2006, Volume: 47, Issue:6 Topics: Algal Proteins; Aniline Compounds; Antibodies, Anti-Idiotypic; Cells, Cultured; Cyclic GMP; Fluoresceins; Fungal Proteins; Molsidomine; Nicotiana; Nitric Oxide; Peroxynitrous Acid; Phytophthora; Proteins; Reactive Oxygen Species; Superoxides; Tyrosine; Uric Acid	2006
NO donors inhibit Na,K-ATPase activity by a protein kinase G-dependent mechanism in the nonpigmented ciliary epithelium of the porcine eye. British journal of pharmacology, 2006, Volume: 148, Issue:6 Topics: Animals; Aqueous Humor; Arginine; Ciliary Body; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitrites; Peroxynitrous Acid; Sodium-Potassium-Exchanging ATPase; Swine	2006
Manipulating glutathione-S-transferases may prevent the development of tolerance to nitroglycerin. Cardiovascular toxicology, 2006, Volume: 6, Issue:2 Topics: Animals; Apoptosis; Blotting, Western; Cell Line; Cyclic GMP; Drug Tolerance; Endothelial Cells; Glutathione Transferase; Mice; Microscopy, Confocal; Muscle, Smooth; Nitric Oxide; Nitric Oxide Synthase Type III; Nitroglycerin; Oxidative Stress; Peroxynitrous Acid; Signal Transduction; Transfection; Vasodilator Agents	2006
Chronic ethanol ingestion increases nitric oxide production in the lung. Alcohol (Fayetteville, N.Y.), 2007, Volume: 41, Issue:5 Topics: Alcohol Drinking; Angiotensin-Converting Enzyme Inhibitors; Animals; Cells, Cultured; Central Nervous System Depressants; Cyclic GMP; Endothelium, Vascular; Ethanol; Hydrogen Peroxide; Lisinopril; Lung; Male; Models, Animal; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Peroxynitrous Acid; Proteins; Rats; Rats, Sprague-Dawley; Renin-Angiotensin System	2007
Peroxynitrite is Involved in the dysfunction of vasorelaxation in SHR/NDmcr-cp rats, spontaneously hypertensive obese rats. Journal of cardiovascular pharmacology, 2007, Volume: 50, Issue:6 Topics: Acetylcholine; Amlodipine; Animals; Aorta, Thoracic; Blood Glucose; Blood Pressure; Blotting, Western; Cholesterol; Cyclic GMP; Dose-Response Relationship, Drug; Heart Rate; Hypertension; Imidazoles; In Vitro Techniques; Insulin; Male; Nitric Oxide Synthase Type III; Nitroprusside; Obesity; Peroxynitrous Acid; Rats; Rats, Inbred SHR; Rats, Mutant Strains; Triglycerides; Vasodilation	2007
Role of redox signaling and poly (adenosine diphosphate-ribose) polymerase activation in vascular smooth muscle cell growth inhibition by nitric oxide and peroxynitrite. Journal of vascular surgery, 2008, Volume: 47, Issue:3 Topics: Animals; Antioxidants; Apoptosis; Cell Proliferation; Cell Survival; Cells, Cultured; Cyclic GMP; DNA Replication; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitric Oxide; Nitric Oxide Donors; Oxidation-Reduction; Peroxynitrous Acid; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Rats; Signal Transduction; Superoxides; Time Factors; Tyrosine; Vasodilation	2008
Nitric oxide decreases expression of osmoprotective genes via direct inhibition of TonEBP transcriptional activity. Pflugers Archiv : European journal of physiology, 2009, Volume: 457, Issue:4 Topics: Active Transport, Cell Nucleus; Animals; Cell Line; Cell Survival; Cyclic GMP; Dogs; Gene Expression Regulation; Genes, Reporter; NFATC Transcription Factors; Nitric Oxide; Nitric Oxide Donors; Peroxynitrous Acid; Transcription, Genetic; Water-Electrolyte Balance	2009
Hydrogen peroxide stimulates the Ca(2+)-activated big-conductance K channels (BK) through cGMP signaling pathway in cultured human endothelial cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2008, Volume: 22, Issue:1-4 Topics: Cells, Cultured; Cyclic GMP; Endothelial Cells; Humans; Hydrogen Peroxide; Ion Channel Gating; Large-Conductance Calcium-Activated Potassium Channels; Microscopy, Confocal; NG-Nitroarginine Methyl Ester; Peroxynitrous Acid	2008
Dose-dependent effects of a selective phosphodiesterase-5-inhibitor on endothelial dysfunction induced by peroxynitrite in rat aorta. European journal of pharmacology, 2009, Aug-01, Volume: 615, Issue:1-3 Topics: Acetylcholine; Animals; Aorta, Thoracic; Cyclic GMP; Dose-Response Relationship, Drug; Endothelium, Vascular; Imidazoles; Immunohistochemistry; In Situ Nick-End Labeling; In Vitro Techniques; Male; Nitroprusside; Oxidative Stress; Peroxynitrous Acid; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Piperazines; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Sulfones; Triazines; Vardenafil Dihydrochloride; Vasodilation; Vasodilator Agents	2009
Pharmacological activation of soluble guanylate cyclase protects the heart against ischemic injury. Circulation, 2009, Aug-25, Volume: 120, Issue:8 Topics: Adrenergic beta-Agonists; Animals; Benzoates; Cardiotonic Agents; Cyclic AMP; Cyclic GMP; Cyclooxygenase 2; Dogs; Female; Gene Expression; Guanylate Cyclase; Heart Function Tests; Isoproterenol; L-Lactate Dehydrogenase; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Survival Rate; Thiobarbituric Acid Reactive Substances; Transforming Growth Factor beta1	2009
Activation of NAD(P)H oxidases by thromboxane A2 receptor uncouples endothelial nitric oxide synthase. Arteriosclerosis, thrombosis, and vascular biology, 2011, Volume: 31, Issue:1 Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Apoptosis; Biopterins; Bridged Bicyclo Compounds, Heterocyclic; Cattle; Cell Survival; Cells, Cultured; Cyclic GMP; Cytochrome P-450 Enzyme System; Endothelial Cells; Enzyme Activation; Enzyme Inhibitors; Fatty Acids, Unsaturated; Intramolecular Oxidoreductases; Mice; Mice, Inbred C57BL; Mice, Knockout; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Peroxynitrous Acid; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Protein Transport; Receptors, Immunologic; Receptors, Thromboxane A2, Prostaglandin H2; RNA Interference; Signal Transduction; Superoxides; Time Factors; Tyrosine	2011
Attenuated vasodilatation in lambs with endogenous and exogenous activation of cGMP signaling: role of protein kinase G nitration. Journal of cellular physiology, 2011, Volume: 226, Issue:12 Topics: Administration, Inhalation; Animals; Animals, Newborn; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinase Type I; Cyclic GMP-Dependent Protein Kinases; Disease Models, Animal; Endothelial Cells; Enzyme Activation; Free Radical Scavengers; Hypertension, Pulmonary; Metalloporphyrins; Molsidomine; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitric Oxide; Nitric Oxide Donors; Peroxynitrous Acid; Polyethylene Glycols; Protein Processing, Post-Translational; Pulmonary Artery; Pulmonary Circulation; Second Messenger Systems; Sheep; Spermine; Superoxide Dismutase; Vasodilation; Vasodilator Agents	2011
Blockade of NADPH oxidase restores vasoreparative function in diabetic CD34+ cells. Investigative ophthalmology & visual science, 2011, Jul-07, Volume: 52, Issue:8 Topics: Acetophenones; Adult; Animals; Antigens, CD34; Benzodioxoles; Chemokine CXCL12; Cyclic GMP; Diabetic Retinopathy; Disease Models, Animal; Endothelium, Vascular; Enzyme Inhibitors; Female; Glycoproteins; Humans; Indans; Male; Mice; Middle Aged; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase Type III; Peroxynitrous Acid; Reperfusion Injury; Reverse Transcriptase Polymerase Chain Reaction; Superoxides; Young Adult	2011
Regulation by mitochondrial superoxide and NADPH oxidase of cellular formation of nitrated cyclic GMP: potential implications for ROS signalling. The Biochemical journal, 2012, Jan-15, Volume: 441, Issue:2 Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Animals; Cell Line, Tumor; Cyclic GMP; Hydrogen Peroxide; Lipopolysaccharides; Mitochondria; NADPH Oxidases; Nitrogen Oxides; Peroxynitrous Acid; Rats; Reactive Nitrogen Species; Reactive Oxygen Species; Rotenone; Signal Transduction; Superoxides	2012
Tetrahydrobiopterin protects soluble guanylate cyclase against oxidative inactivation. Molecular pharmacology, 2012, Volume: 82, Issue:3 Topics: Animals; Aorta; Biopterins; Cardiovascular Diseases; Cells, Cultured; Cyclic GMP; Endothelial Cells; Fibroblasts; Guanylate Cyclase; Heme; Nitric Oxide; Nitric Oxide Synthase; Nitroglycerin; Oxidation-Reduction; Oxidative Stress; Peroxynitrous Acid; Pterins; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Superoxides; Swine	2012
Nitric oxide- and heme-independent activation of soluble guanylate cyclase attenuates peroxynitrite-induced endothelial dysfunction in rat aorta. Journal of cardiovascular pharmacology and therapeutics, 2013, Volume: 18, Issue:1 Topics: Animals; Aorta, Thoracic; Benzoates; Cyclic GMP; DNA Breaks; Endothelium, Vascular; Guanylate Cyclase; Heme; In Vitro Techniques; Male; Nitric Oxide; Oxidative Stress; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Vasodilation	2013
Peroxynitrite mediates testosterone-induced vasodilation of microvascular resistance vessels. The Journal of pharmacology and experimental therapeutics, 2013, Volume: 345, Issue:1 Topics: Androgens; Animals; Blotting, Western; Cyclic GMP; Electron Spin Resonance Spectroscopy; In Vitro Techniques; Male; Microvessels; Nitric Oxide; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Superoxides; Testosterone; Vascular Resistance; Vasodilation; Xanthine Oxidase	2013
Nitration of tyrosine 247 inhibits protein kinase G-1α activity by attenuating cyclic guanosine monophosphate binding. The Journal of biological chemistry, 2014, Mar-14, Volume: 289, Issue:11 Topics: Adult; Animals; Aorta; Cardiovascular Diseases; Catalytic Domain; Cell Differentiation; Cell Proliferation; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinase Type I; Female; HEK293 Cells; Humans; Male; Mass Spectrometry; Middle Aged; Models, Molecular; Myocytes, Smooth Muscle; Nitrogen; Peroxynitrous Acid; Protein Binding; Sheep; Tyrosine; Young Adult	2014
Effects of peroxynitrite on relaxation through the NO/sGC/cGMP pathway in isolated rat iliac arteries. Journal of vascular research, 2014, Volume: 51, Issue:6 Topics: Animals; Antioxidants; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Activators; Guanylate Cyclase; Iliac Artery; Male; Nitric Oxide; Oxidation-Reduction; Peroxynitrous Acid; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Second Messenger Systems; Soluble Guanylyl Cyclase; Vasodilation; Vasodilator Agents	2014
Double-Edged Roles of Nitric Oxide Signaling on APP Processing and Amyloid-β Production In Vitro: Preliminary Evidence from Sodium Nitroprusside. Neurotoxicity research, 2016, Volume: 29, Issue:1 Topics: ADAM Proteins; ADAM10 Protein; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Carbazoles; Cell Line, Tumor; Cyclic GMP; Cyclic N-Oxides; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation; Humans; Imidazoles; Membrane Proteins; Neuroblastoma; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Peroxynitrous Acid; Signal Transduction; Superoxides; Transfection	2016
Nitric Oxide Production in the Striatum and Cerebellum of a Rat Model of Preterm Global Perinatal Asphyxia. Neurotoxicity research, 2017, Volume: 31, Issue:3 Topics: Animals; Apoptosis; Asphyxia Neonatorum; Astrocytes; Caspase 3; Cerebellum; Corpus Striatum; Cyclic GMP; Female; Male; Nitric Oxide; Nitric Oxide Synthase Type I; Peroxynitrous Acid; Postpartum Period; Pregnancy; Rats	2017
Cyclosporin A Inhibits the Activation of Membrane-Bound Guanylate Cyclase GC-A of Atrial Natriuretic Factor via NAD(P)H Oxidase. Chemical & pharmaceutical bulletin, 2022, Volume: 70, Issue:11 Topics: Animals; Atrial Natriuretic Factor; Cyclic GMP; Cyclosporine; Diamide; Guanylate Cyclase; Humans; NADPH Oxidases; Peroxynitrous Acid; Superoxides; Swine; Vitamin K 3	2022