Page last updated: 2024-09-03

peroxynitrous acid and aspirin

peroxynitrous acid has been researched along with aspirin in 9 studies

Compound Research Comparison

Studies
(peroxynitrous acid)
Trials
(peroxynitrous acid)
Recent Studies (post-2010)
(peroxynitrous acid)
Studies
(aspirin)
Trials
(aspirin)
Recent Studies (post-2010) (aspirin)
3,303211,23048,9476,81713,778

Protein Interaction Comparison

ProteinTaxonomyperoxynitrous acid (IC50)aspirin (IC50)
Prostaglandin G/H synthase 1 Bos taurus (cattle)0.35
Integrin beta-3Homo sapiens (human)5
Prostaglandin G/H synthase 1Ovis aries (sheep)0.8252
Seed linoleate 13S-lipoxygenase-1Glycine max (soybean)1.375
Integrin alpha-IIbHomo sapiens (human)5
Prostaglandin G/H synthase 1Homo sapiens (human)2.271
Substance-P receptorCavia porcellus (domestic guinea pig)2.4
Prostaglandin G/H synthase 2Homo sapiens (human)2.15
Urotensin-2 receptorRattus norvegicus (Norway rat)0.3
4-aminobutyrate aminotransferase, mitochondrialRattus norvegicus (Norway rat)2.4
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)0.35
Prostaglandin G/H synthase 2Ovis aries (sheep)2.4081

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's6 (66.67)29.6817
2010's2 (22.22)24.3611
2020's1 (11.11)2.80

Authors

AuthorsStudies
Bradley, NJ; Bruckdorfer, KR; Jacobs, M; Khan, J; Low, SY; Naseem, KM; Sabetkar, M1
Filep, JG; József, L; Petasis, NA; Serhan, CN; Zouki, C1
Korda, M; Madajka, M; Malinski, T; White, J1
Whittle, BJ1
Colantuono, G; Khan, M; Kumbala, D; Kuppusamy, P; Kutala, VK; Mandal, R; Potaraju, V1
Chen, W; Jia, Z; Li, J; Li, Y; Misra, HP; Zhou, K; Zhu, H1
Davì, G; La Barba, S; Lapenna, D; Santilli, F1
Bauer, G1
Bortner, CD; Sinha, BK; Tokar, EJ1

Reviews

2 review(s) available for peroxynitrous acid and aspirin

ArticleYear
Nitric oxide-modulating agents for gastrointestinal disorders.
    Expert opinion on investigational drugs, 2005, Volume: 14, Issue:11

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Enteritis; Esophagus; Fissure in Ano; Gastric Emptying; Gastrointestinal Diseases; Gastrointestinal Motility; Humans; Naproxen; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type II; Peroxynitrous Acid

2005
Oxidative stress-related mechanisms affecting response to aspirin in diabetes mellitus.
    Free radical biology & medicine, 2015, Volume: 80

    Topics: Aldehyde Reductase; Aspirin; Blood Platelets; Diabetes Mellitus, Type 2; F2-Isoprostanes; Glucose; Glycosylation; Humans; Lipid Peroxides; Nitric Oxide; Oxidative Stress; Peroxynitrous Acid; Platelet Activation; Platelet Aggregation Inhibitors; Thrombosis; Thromboxane A2

2015

Other Studies

7 other study(ies) available for peroxynitrous acid and aspirin

ArticleYear
The nitration of platelet cytosolic proteins during agonist-induced activation of platelets.
    FEBS letters, 2000, May-04, Volume: 473, Issue:1

    Topics: Aspirin; Blood Platelets; Blood Proteins; Blotting, Western; Cell Adhesion Molecules; Collagen; Cyclooxygenase Inhibitors; Cytosol; Enzyme-Linked Immunosorbent Assay; Humans; Membrane Proteins; Microfilament Proteins; Molecular Weight; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide Synthase; Nitrous Acid; Oxidants; Peroxynitrous Acid; Phosphoproteins; Platelet Activation; Thrombin; Tyrosine

2000
Lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 inhibit peroxynitrite formation, NF-kappa B and AP-1 activation, and IL-8 gene expression in human leukocytes.
    Proceedings of the National Academy of Sciences of the United States of America, 2002, Oct-01, Volume: 99, Issue:20

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Cell Nucleus; Cell Survival; Dose-Response Relationship, Drug; Humans; Hydroxyeicosatetraenoic Acids; Interleukin-8; Leukocytes; Lipoxins; Lymphocytes; Neutrophils; NF-kappa B; Peroxynitrous Acid; Ribonucleases; Superoxides; Transcription Factor AP-1

2002
Effect of aspirin on constitutive nitric oxide synthase and the biovailability of NO.
    Thrombosis research, 2003, Jun-15, Volume: 110, Issue:5-6

    Topics: Animals; Arginine; Aspirin; Cells, Cultured; Dose-Response Relationship, Drug; Endothelial Cells; Humans; Nitric Oxide; Nitric Oxide Synthase; PC12 Cells; Peroxynitrous Acid; Rats; Superoxides; Umbilical Veins

2003
Prevention of postischemic myocardial reperfusion injury by the combined treatment of NCX-4016 and Tempol.
    Journal of cardiovascular pharmacology, 2006, Volume: 48, Issue:3

    Topics: Animals; Aspirin; Creatine Kinase; Cyclic N-Oxides; L-Lactate Dehydrogenase; Myocardial Ischemia; Myocardial Reperfusion Injury; Nitric Oxide; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Spin Labels; Superoxide Dismutase; Superoxides; Uric Acid

2006
Inhibition of peroxynitrite-mediated DNA strand cleavage and hydroxyl radical formation by aspirin at pharmacologically relevant concentrations: implications for cancer intervention.
    Biochemical and biophysical research communications, 2009, Dec-04, Volume: 390, Issue:1

    Topics: Anticarcinogenic Agents; Aspirin; Bacteriophage phi X 174; DNA Cleavage; Humans; Hydroxyl Radical; Molsidomine; Neoplasms; Peroxynitrous Acid; Plasmids

2009
Increasing the endogenous NO level causes catalase inactivation and reactivation of intercellular apoptosis signaling specifically in tumor cells.
    Redox biology, 2015, Volume: 6

    Topics: Apoptosis; Aspirin; Catalase; Cell Line, Tumor; fas Receptor; Gene Expression Regulation, Neoplastic; Humans; Hydrogen Peroxide; Hypochlorous Acid; Metalloporphyrins; Neoplasms; Nitrates; Nitric Oxide; Peroxynitrous Acid; Proton Pumps; Signal Transduction; Singlet Oxygen

2015
Molecular Mechanisms of Cytotoxicity of NCX4040, the Non-Steroidal Anti-Inflammatory NO-Donor, in Human Ovarian Cancer Cells.
    International journal of molecular sciences, 2022, Aug-03, Volume: 23, Issue:15

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Aspirin; Carcinoma, Ovarian Epithelial; Doxorubicin; Female; Humans; Nitro Compounds; Ovarian Neoplasms; Peroxynitrous Acid; Reactive Nitrogen Species; Reactive Oxygen Species

2022