Page last updated: 2024-09-03

peroxynitrous acid and acetylcysteine

peroxynitrous acid has been researched along with acetylcysteine in 27 studies

Compound Research Comparison

Studies
(peroxynitrous acid)
Trials
(peroxynitrous acid)
Recent Studies (post-2010)
(peroxynitrous acid)
Studies
(acetylcysteine)
Trials
(acetylcysteine)
Recent Studies (post-2010) (acetylcysteine)
3,303211,23014,5801,0465,960

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's15 (55.56)29.6817
2010's12 (44.44)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Gieche, J; Grune, T; Klotz, LO; Rudeck, M; Sies, H1
Besner, JG; Bouchard, JF; Cabassi, A; de Champlain, J; Dumont, EC; Girouard, H; Lamontagne, D; Le Jossec, M1
D'Alfonso, C; Failli, P; Generini, S; Giovannelli, L; Matucci-Cerinic, M; Orsi, S; Palmieri, L; Pignone, A; Rosso, AD; Stanflin, N; Zilletti, L1
Kastenbauer, S; Klein, M; Koedel, U; Pfister, HW1
Cheema, SS; Lopes, EC; Turner, BJ1
Cinel, I; Cinel, L; Ercan, B; Kanik, A; Koksel, O; Oral, U; Ozdulger, A; Tamer, L1
Cook, CC; Hinson, JA; Light, KE; Pierce, DR1
Brüne, B; Köhl, R; Zhou, J1
Chang, T; Meng, QH; Wang, H; Wu, L1
Alvarez-Barrientos, A; Fernández, AP; Lamas, S; León-Gómez, E; Navarro-Antolín, J; Redondo-Horcajo, M; Rodrigo, J; Zaragoza, C1
Carbonell, LF; Cuevas, S; Díaz, J; Fenoy, F; Hernández, I; Quesada, T; Salom, MG; Valero, F1
Celedón, G; González, G; Lissi, EA; Pino, J1
Corstjens, H; Declercq, L; Hellemans, L; Maes, D; Sente, I1
Burke, AS; Hinson, JA; James, LP; Kurten, RC; Redeker, K1
Kumar, S; Sitasawad, SL1
Abdelsaid, MA; Al-Shabrawey, M; El-Remessy, AB; Matragoon, S; Pillai, BA; Prakash, R1
Jaeschke, H; Saito, C; Zwingmann, C1
McCarty, MF1
Alleyne, CH; Dhandapani, KM; Laird, MD; Singh, N; Sukumari-Ramesh, S; Vender, JR1
Evans, LC; Liu, H; Pinkas, GA; Thompson, LP1
Akgul, Y; Cheong, N; Dannevig, I; Liao, J; Longoria, C; Mahendroo, M; Mija, DS; Nakstad, B; Ramgopal, M; Saugstad, OD; Savani, RC; Wyckoff, MH; Østerholt, HC1
Adamus, J; Dębski, D; Kalyanaraman, B; Marcinek, A; Michałowski, B; Sikora, A; Smulik, R; Zielonka, J1
Belhomme, M; Buzzacott, P; Guerrero, F; Lambrechts, K; Mazur, A; Theron, M; Wang, Q1
Lee, CT; Wang, JY; Yu, LE1
Eder, C; Miralles, F; Schilling, T; Spencer, NG1
Brooks, AD; Ercan, UK; Joshi, SG; Sen, B1
Chang, WH; Chen, LW; Chen, PH; Tsay, TB; Yang, MC1

Reviews

1 review(s) available for peroxynitrous acid and acetylcysteine

ArticleYear
Practical prevention of cardiac remodeling and atrial fibrillation with full-spectrum antioxidant therapy and ancillary strategies.
    Medical hypotheses, 2010, Volume: 75, Issue:2

    Topics: Acetylcysteine; Antioxidants; Apoptosis; Atrial Fibrillation; Fibrosis; Heart Failure; Humans; Mitochondria; Myocardial Infarction; Myocardium; Myocytes, Cardiac; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxidative Stress; Peroxynitrous Acid; Superoxides

2010

Other Studies

26 other study(ies) available for peroxynitrous acid and acetylcysteine

ArticleYear
Protein oxidation and proteolysis by the nonradical oxidants singlet oxygen or peroxynitrite.
    Free radical biology & medicine, 2001, Jun-01, Volume: 30, Issue:11

    Topics: Acetylcysteine; Animals; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Ferritins; Free Radicals; Hydrogen Peroxide; Liver; Multienzyme Complexes; Naphthols; Nitric Oxide; Oxidation-Reduction; Peroxynitrous Acid; Proteasome Endopeptidase Complex; Proteins; Rats; Singlet Oxygen; Tyrosine

2001
Effects of chronic N-acetylcysteine treatment on the actions of peroxynitrite on aortic vascular reactivity in hypertensive rats.
    Journal of hypertension, 2001, Volume: 19, Issue:7

    Topics: Acetylcholine; Acetylcysteine; Animals; Aorta; Drug Synergism; Free Radical Scavengers; Glutathione; Glutathione Disulfide; Hypertension; In Vitro Techniques; Isoproterenol; Male; Malondialdehyde; Nitrates; Nitroprusside; Peroxynitrous Acid; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Time Factors; Tyrosine; Vasodilation; Vasodilator Agents; Vasomotor System

2001
Effect of N-acetyl-L-cysteine on peroxynitrite and superoxide anion production of lung alveolar macrophages in systemic sclerosis.
    Nitric oxide : biology and chemistry, 2002, Volume: 7, Issue:4

    Topics: Acetylcysteine; Bronchoalveolar Lavage Fluid; Female; Humans; Immunohistochemistry; Lung; Macrophages, Alveolar; Male; Middle Aged; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Scleroderma, Systemic; Superoxides

2002
Meningitis-associated hearing loss: protection by adjunctive antioxidant therapy.
    Annals of neurology, 2003, Volume: 54, Issue:4

    Topics: Acetylcysteine; Animals; Anti-Bacterial Agents; Antioxidants; Audiometry; Ceftriaxone; Cell Count; Cochlea; Disease Models, Animal; Drug Interactions; Evans Blue; Evoked Potentials, Auditory, Brain Stem; Hearing Loss; Labyrinthitis; Male; Meningitis, Pneumococcal; Metalloporphyrins; Peroxynitrous Acid; Rats; Rats, Wistar; Spiral Ganglion; Time Factors

2003
Inducible superoxide dismutase 1 aggregation in transgenic amyotrophic lateral sclerosis mouse fibroblasts.
    Journal of cellular biochemistry, 2004, Apr-01, Volume: 91, Issue:5

    Topics: Acetylcysteine; Amyotrophic Lateral Sclerosis; Animals; Animals, Newborn; Blotting, Western; Cell Survival; Chelating Agents; Chlorides; Copper; Detergents; Disease Models, Animal; Ditiocarb; Fibroblasts; Humans; Immunohistochemistry; Mice; Mice, Transgenic; Minocycline; Mutation; Oxidative Stress; Paraquat; Peroxynitrous Acid; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Binding; Solubility; Spinal Cord; Superoxide Dismutase; Superoxide Dismutase-1; Zinc Compounds

2004
N-acetylcysteine inhibits peroxynitrite-mediated damage in oleic acid-induced lung injury.
    Pulmonary pharmacology & therapeutics, 2004, Volume: 17, Issue:5

    Topics: Acetylcysteine; Animals; Female; Lung; Malondialdehyde; Microscopy; Oleic Acid; Peroxidase; Peroxynitrous Acid; Rats; Rats, Wistar; Tyrosine

2004
Are oxidative mechanisms primary in ethanol induced Purkinje neuron death of the neonatal rat?
    Neuroscience letters, 2006, May-29, Volume: 400, Issue:1-2

    Topics: Acetylcysteine; Animals; Animals, Newborn; Cell Count; Cell Death; Cerebellum; Drug Interactions; Enzyme-Linked Immunosorbent Assay; Female; Free Radical Scavengers; Male; Peroxynitrous Acid; Pregnancy; Purkinje Cells; Rats; Rats, Sprague-Dawley; Time Factors; Tyrosine

2006
Reactive oxygen species attenuate nitric-oxide-mediated hypoxia-inducible factor-1alpha stabilization.
    Free radical biology & medicine, 2006, Apr-15, Volume: 40, Issue:8

    Topics: Acetylcysteine; Active Transport, Cell Nucleus; Apoptosis; Catalase; Cell Extracts; Cell Line; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Naphthoquinones; Nitric Oxide; Peroxynitrous Acid; Protein Biosynthesis; Reactive Oxygen Species; Time Factors; Transcriptional Activation

2006
Fructose-induced peroxynitrite production is mediated by methylglyoxal in vascular smooth muscle cells.
    Life sciences, 2006, Nov-25, Volume: 79, Issue:26

    Topics: Acetylcysteine; Animals; Cell Line; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fructose; Glutathione; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Peroxynitrous Acid; Pyruvaldehyde; Superoxide Dismutase; Superoxides; Time Factors

2006
Role of peroxynitrite in endothelial damage mediated by Cyclosporine A.
    Free radical biology & medicine, 2007, Feb-01, Volume: 42, Issue:3

    Topics: Acetylcysteine; Animals; Antioxidants; Aorta; Cattle; Cell Membrane; Cell Survival; Cells, Cultured; Cyclosporine; Endothelial Cells; Immunosuppressive Agents; Mice; Mice, Inbred C57BL; Nitric Oxide; Peroxynitrous Acid; Superoxide Dismutase; Tyrosine

2007
N-acetylcysteine exerts protective effects and prevents lung redox imbalance and peroxynitrite generation in endotoxemic rats.
    Medicinal chemistry (Shariqah (United Arab Emirates)), 2007, Volume: 3, Issue:1

    Topics: Acetylcysteine; Animals; Coloring Agents; Endotoxemia; Enzyme Inhibitors; Free Radical Scavengers; Lactic Acid; Lipopolysaccharides; Lung; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxidation-Reduction; Peroxynitrous Acid; Platelet Count; Rats; Rats, Wistar; Rhodamines; Sulfhydryl Compounds; Thiobarbituric Acid Reactive Substances

2007
Peroxynitrite oxidizes erythrocyte membrane band 3 protein and diminishes its anion transport capacity.
    Free radical research, 2007, Volume: 41, Issue:3

    Topics: Acetylcysteine; Anion Exchange Protein 1, Erythrocyte; Anions; Catechin; Erythrocytes; Hemoglobins; Humans; Ion Transport; Nitrates; Oxidants; Oxidation-Reduction; Peroxynitrous Acid; Tyrosine

2007
Prevention of oxidative damage that contributes to the loss of bioenergetic capacity in ageing skin.
    Experimental gerontology, 2007, Volume: 42, Issue:9

    Topics: Acetylcysteine; Catalase; Creatine Kinase; Energy Metabolism; Female; Free Radical Scavengers; Humans; Hydrogen Peroxide; Linear Models; Organometallic Compounds; Oxidative Stress; Peroxynitrous Acid; Pyruvaldehyde; Reactive Oxygen Species; Salicylates; Skin; Skin Aging

2007
Mechanisms of chloroform-induced hepatotoxicity: oxidative stress and mitochondrial permeability transition in freshly isolated mouse hepatocytes.
    Journal of toxicology and environmental health. Part A, 2007, Volume: 70, Issue:22

    Topics: Acetylcysteine; Alanine Transaminase; Animals; Antioxidants; Cells, Cultured; Chloroform; Cyclosporine; Female; Glutathione; Hepatocytes; Membrane Potential, Mitochondrial; Mice; Mice, Inbred Strains; Mitochondria, Liver; Nitric Oxide Synthase; Oxidative Stress; Peroxynitrous Acid; Reactive Oxygen Species; Tyrosine

2007
N-acetylcysteine prevents glucose/glucose oxidase-induced oxidative stress, mitochondrial damage and apoptosis in H9c2 cells.
    Life sciences, 2009, Mar-13, Volume: 84, Issue:11-12

    Topics: Acetylcysteine; Animals; Apoptosis; Blotting, Western; Cell Line; Cytochromes c; Dose-Response Relationship, Drug; Glucose; Glucose Oxidase; Hyperglycemia; Membrane Potential, Mitochondrial; Mitochondria, Heart; Myocytes, Cardiac; Oxidative Stress; Peroxynitrous Acid; Reactive Oxygen Species

2009
Early intervention of tyrosine nitration prevents vaso-obliteration and neovascularization in ischemic retinopathy.
    The Journal of pharmacology and experimental therapeutics, 2010, Volume: 332, Issue:1

    Topics: Acetylcysteine; Animals; Animals, Newborn; Apoptosis; Blotting, Western; Catechin; Cells, Cultured; Disease Models, Animal; Endothelial Cells; Glutathione; Hyperoxia; Hypoxia; Ischemia; Lipid Peroxidation; Metalloporphyrins; Mice; Mice, Inbred C57BL; Peroxynitrous Acid; Protective Agents; Retinal Neovascularization; Retinal Vessels; Tyrosine

2010
Novel mechanisms of protection against acetaminophen hepatotoxicity in mice by glutathione and N-acetylcysteine.
    Hepatology (Baltimore, Md.), 2010, Volume: 51, Issue:1

    Topics: Acetaminophen; Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Drug Overdose; Energy Metabolism; Glutathione; Male; Mice; Mice, Inbred C3H; Mitochondria, Liver; Peroxynitrous Acid; Reactive Oxygen Species; Up-Regulation

2010
Astrocyte-derived glutathione attenuates hemin-induced apoptosis in cerebral microvascular cells.
    Glia, 2010, Nov-15, Volume: 58, Issue:15

    Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Animals; Antioxidants; Apoptosis; Ascorbic Acid; Astrocytes; Brain; Caspase 3; Cells, Cultured; Curcumin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glutathione; Hemin; Humans; L-Lactate Dehydrogenase; Mice; Microvessels; Neuroprotective Agents; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Time Factors

2010
Chronic hypoxia increases peroxynitrite, MMP9 expression, and collagen accumulation in fetal guinea pig hearts.
    Pediatric research, 2012, Volume: 71, Issue:1

    Topics: Acetylcysteine; Animals; Body Weight; Collagen; Female; Fetal Heart; Guinea Pigs; Hypoxia; Lipid Peroxidation; Matrix Metalloproteinase 9; Nitric Oxide Synthase Type II; Organ Size; Peroxynitrous Acid; Pregnancy; Tyrosine

2012
Antioxidant protects against increases in low molecular weight hyaluronan and inflammation in asphyxiated newborn pigs resuscitated with 100% oxygen.
    PloS one, 2012, Volume: 7, Issue:6

    Topics: Acetylcysteine; Analysis of Variance; Animals; Animals, Newborn; Antioxidants; Asphyxia; Bronchoalveolar Lavage; DNA Primers; Enzyme-Linked Immunosorbent Assay; Hyaluronic Acid; Interleukin-1beta; Lung; Oxidative Stress; Oxygen Inhalation Therapy; Peroxynitrous Acid; Real-Time Polymerase Chain Reaction; Sus scrofa; Tumor Necrosis Factor-alpha; Tyrosine

2012
Nitroxyl (HNO) reacts with molecular oxygen and forms peroxynitrite at physiological pH. Biological Implications.
    The Journal of biological chemistry, 2014, Dec-19, Volume: 289, Issue:51

    Topics: Acetylcysteine; Algorithms; Animals; Boron Compounds; Boronic Acids; Captopril; Cattle; Chromatography, High Pressure Liquid; Coumarins; Cysteine; Dithiothreitol; Humans; Hydrogen Sulfide; Hydrogen-Ion Concentration; Kinetics; Mass Spectrometry; Models, Chemical; Nitrogen Oxides; Oxidation-Reduction; Oxygen; Peroxynitrous Acid; Serum Albumin; Spectrophotometry; Sulfhydryl Compounds

2014
Antioxidants, endothelial dysfunction, and DCS: in vitro and in vivo study.
    Journal of applied physiology (Bethesda, Md. : 1985), 2015, Dec-15, Volume: 119, Issue:12

    Topics: Acetylcysteine; Angiotensin II; Animals; Antioxidants; Ascorbic Acid; Cell Death; Cell Survival; Cells, Cultured; Decompression Sickness; Diving; Endothelium, Vascular; Glutathione; Male; Nitric Oxide; Oxidative Stress; Peptidyl-Dipeptidase A; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Superoxides; Thiobarbituric Acid Reactive Substances

2015
Nitroxide antioxidant as a potential strategy to attenuate the oxidative/nitrosative stress induced by hydrogen peroxide plus nitric oxide in cultured neurons.
    Nitric oxide : biology and chemistry, 2016, Apr-01, Volume: 54

    Topics: Acetylcysteine; Animals; Antioxidants; Catalase; Cyclic N-Oxides; Hydrogen Peroxide; L-Lactate Dehydrogenase; Neurons; Nitric Oxide; Nitric Oxide Donors; Nitrites; Oxidative Stress; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Reactive Nitrogen Species; Reactive Oxygen Species; S-Nitroso-N-Acetylpenicillamine; Superoxide Dismutase; Thiourea; Uric Acid

2016
Mechanisms Underlying Interferon-γ-Induced Priming of Microglial Reactive Oxygen Species Production.
    PloS one, 2016, Volume: 11, Issue:9

    Topics: Acetylcysteine; Adenosine Triphosphate; Animals; Cell Line; Enzyme Inhibitors; Gene Expression Regulation; Glutathione; Glycoproteins; Imidazoles; Interferon-gamma; Membrane Glycoproteins; Mice; Microglia; NADPH Oxidase 2; NADPH Oxidases; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Peroxynitrous Acid; Phenanthrolines; Potassium Channels, Inwardly Rectifying; Pyridines; Reactive Oxygen Species; Signal Transduction

2016
Escherichia coli cellular responses to exposure to atmospheric-pressure dielectric barrier discharge plasma-treated N-acetylcysteine solution.
    Journal of applied microbiology, 2018, Volume: 125, Issue:2

    Topics: Acetylcysteine; DNA Damage; Escherichia coli; Gene Expression; Humans; Nitrosative Stress; Oxidative Stress; Peroxynitrous Acid; Plasma

2018
Lactobacillus salivarius reverse antibiotic-induced lung defense impairment in a ventilator model.
    Journal of translational medicine, 2018, 08-13, Volume: 16, Issue:1

    Topics: Acetylcysteine; Animals; Anti-Bacterial Agents; DNA; Hormones, Ectopic; Intercellular Signaling Peptides and Proteins; Intestinal Mucosa; Ligilactobacillus salivarius; Lung; Macrophages, Alveolar; Mice, Inbred C57BL; Myeloid Differentiation Factor 88; Neutrophil Infiltration; NF-kappa B; Pancreatitis-Associated Proteins; Peroxynitrous Acid; Phagocytosis; Pneumonia; Protein Binding; Pseudomonas aeruginosa; Reactive Oxygen Species; Toll-Like Receptor 4; Ventilators, Mechanical

2018