Page last updated: 2024-09-03

peroxynitrous acid and acetaminophen

peroxynitrous acid has been researched along with acetaminophen in 39 studies

Compound Research Comparison

Studies
(peroxynitrous acid)
Trials
(peroxynitrous acid)
Recent Studies (post-2010)
(peroxynitrous acid)
Studies
(acetaminophen)
Trials
(acetaminophen)
Recent Studies (post-2010) (acetaminophen)
3,303211,23020,6962,8488,242

Protein Interaction Comparison

ProteinTaxonomyperoxynitrous acid (IC50)acetaminophen (IC50)
MyoglobinHomo sapiens (human)2.3

Research

Studies (39)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's18 (46.15)29.6817
2010's13 (33.33)24.3611
2020's8 (20.51)2.80

Authors

AuthorsStudies
Goldberg, E; Merrill, GF1
Farhood, A; Ho, YS; Jaeschke, H; Knight, TR1
Golfetti, R; Merrill, G; Rork, T; Spiler, N; VanDyke, K1
Golfetti, R; Merrill, G; Rork, T1
Bajt, ML; Jaeschke, H; Knight, TR1
Bajt, ML; Farhood, A; Jaeschke, H; Knight, TR1
Hinson, JA; Jaeschke, H; James, LP; Knight, TR; McCullough, SS1
Merrill, GF; Rork, TH; Spiler, NM; Van Dyke, K1
Bajt, ML; Cover, C; Jaeschke, H; Knight, TR; Lemasters, JJ; Mansouri, A; Pessayre, D1
Bajt, ML; Jaeschke, H1
Hadzimichalis, NM; Kappil, MA; Merrill, GF; Rork, TH1
Lei, XG; Zhu, JH1
Aregullin, M; Lei, XG; McClung, JP; Roneker, CA; Zhu, JH1
Hirose, M; Ishii, Y; Ito, R; Iwasaki, Y; Katsumata, T; Nakazawa, H; Nishikawa, A; Ogara, A; Saito, K; Umemura, T1
Boelsterli, UA; Goh, CW; Latchoumycandane, C; Ong, MM1
Bachschmid, MM; Cohen, RA; Daiber, A; Ghisla, S; Schildknecht, S1
Bajt, ML; Farhood, A; Jaeschke, H; Lemasters, JJ1
Adiguzel, K; Akgoz, M; Cigremis, Y; Karaman, M; Kart, A; Ozen, H; Turel, H1
Jaeschke, H; Saito, C; Zwingmann, C1
Chiron, S; Fenet, H; Gomez, E1
Jaeschke, H; Lemasters, JJ; Saito, C1
Baines, CP; Jaeschke, H; Lebofsky, M; Lemasters, JJ; Ramachandran, A1
Bajt, ML; Farhood, A; Jaeschke, H; Lebofsky, M; Lemasters, JJ; Ramachandran, A; Yan, HM1
Boelsterli, UA; LoGuidice, A1
Jaeschke, H; McGill, MR; Ramachandran, A1
Jones, GR1
Alder, NN; Boelsterli, UA; Chamberland, SR; Imaizumi, N; Lee, KK1
Anraku, M; Hirayama, F; Iohara, D; Irie, T; Ishitsuka, Y; Uekama, K; Umezaki, Y1
Bajt, ML; Du, K; Jaeschke, H; McGill, MR; Xie, Y1
Alhoshan, MS; El-Toni, AM; Fan, Y; Lei, Z; Li, D; Sun, C; Wang, S; Zhang, F1
Fei, J; Jiang, WL; Li, CY; Li, Y; Wang, WX; Zhao, YT1
Chen, J; Cui, M; Deng, D; Gu, Y; Ling, C; Wang, P; Xia, L1
Chen, Y; Han, X; Li, B; Wei, P; Yi, T; Yuan, W; Zhang, M; Zhao, M; Zhuang, H1
Cheng, D; Gong, X; Lv, Y; Wu, Q; Yuan, J; Yuan, L; Zhang, X1
Deng, Y; Feng, G1
Chau, JHC; Kwok, RTK; Lam, JWY; Lam, KWK; Lee, MMS; Tang, BZ; Yu, EY; Zhang, R1
Jin, HW; Wang, G; Wang, J; Xu, BX; Xu, ST; Xu, YW; Zhen, L1
Adelusi, OB; Jaeschke, H; Lemasters, JJ; Ramachandran, A1
Marcinek, A; Michalski, R; Pierzchała, K; Pięta, J; Pięta, M; Rola, M; Sikora, A; Zielonka, J1

Reviews

3 review(s) available for peroxynitrous acid and acetaminophen

ArticleYear
The role of oxidant stress and reactive nitrogen species in acetaminophen hepatotoxicity.
    Toxicology letters, 2003, Oct-15, Volume: 144, Issue:3

    Topics: Acetaminophen; Adenosine Triphosphate; Analgesics, Non-Narcotic; Animals; Apoptosis; Humans; Lipid Peroxidation; Liver; Mitochondria; Models, Animal; Necrosis; Oxidative Stress; Peroxynitrous Acid; Reactive Nitrogen Species

2003
Intracellular signaling mechanisms of acetaminophen-induced liver cell death.
    Toxicological sciences : an official journal of the Society of Toxicology, 2006, Volume: 89, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Apoptosis; Cell Death; DNA Fragmentation; Hepatocytes; Liver; Necrosis; Peroxynitrous Acid; Signal Transduction

2006
Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity.
    Drug metabolism reviews, 2012, Volume: 44, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Antioxidants; Apoptosis; Cell Death; Chemical and Drug Induced Liver Injury; DNA Fragmentation; Humans; Inflammation; Liver; Mitochondria; Necrosis; Oxidants; Oxidative Stress; Peroxynitrous Acid; Reactive Oxygen Species

2012

Other Studies

36 other study(ies) available for peroxynitrous acid and acetaminophen

ArticleYear
Antioxidant properties of acetaminophen and cardioprotection.
    Basic research in cardiology, 2001, Volume: 96, Issue:5

    Topics: Acetaminophen; Action Potentials; Analgesics, Non-Narcotic; Animals; Antioxidants; Cardiotonic Agents; Female; GABA Modulators; Guinea Pigs; Heart Conduction System; Hydroxyl Radical; In Vitro Techniques; Male; Myocardial Ischemia; Myocardium; Pentobarbital; Peroxynitrous Acid; Ventricular Premature Complexes

2001
Peroxynitrite is a critical mediator of acetaminophen hepatotoxicity in murine livers: protection by glutathione.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 303, Issue:2

    Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Antidotes; Chemical and Drug Induced Liver Injury; Glutathione; Immunohistochemistry; Injections, Intravenous; Liver; Male; Mice; Mice, Inbred C3H; Mitochondria, Liver; Necrosis; Peroxynitrous Acid; Serum Albumin, Bovine; Tyrosine

2002
Acetaminophen in the post-ischemia reperfused myocardium.
    Experimental biology and medicine (Maywood, N.J.), 2002, Volume: 227, Issue:11

    Topics: Acetaminophen; Animals; Creatine Kinase; Female; Guinea Pigs; Heart; Male; Myocardial Ischemia; Myocardial Reperfusion; Peroxynitrous Acid; Uric Acid

2002
Chronically administered acetaminophen and the ischemia/reperfused myocardium.
    Experimental biology and medicine (Maywood, N.J.), 2003, Volume: 228, Issue:6

    Topics: Acetaminophen; Animals; Cardiotonic Agents; Coronary Circulation; Creatine Kinase; Female; Guinea Pigs; Heart; Luminescent Measurements; Male; Microscopy, Electron; Myocardial Ischemia; Myocardial Reperfusion Injury; Peroxynitrous Acid; Time Factors; Ventricular Function, Left

2003
Scavenging peroxynitrite with glutathione promotes regeneration and enhances survival during acetaminophen-induced liver injury in mice.
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 307, Issue:1

    Topics: Acetaminophen; Animals; Disease Models, Animal; Glutathione; Glutathione Disulfide; Immunohistochemistry; Liver Regeneration; Male; Mice; Mice, Inbred C3H; Peroxynitrous Acid; Respiratory Distress Syndrome; Survival Rate

2003
Acetaminophen toxicity in mice lacking NADPH oxidase activity: role of peroxynitrite formation and mitochondrial oxidant stress.
    Free radical research, 2003, Volume: 37, Issue:12

    Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Endothelium, Vascular; Glutathione; Glutathione Disulfide; Hepatocytes; Hydrogen Peroxide; Macrophages; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria, Liver; NADPH Oxidase 2; NADPH Oxidases; Oxidative Stress; Peroxynitrous Acid; Superoxides; Tyrosine

2003
Acetaminophen in the hypoxic and reoxygenated guinea pig myocardium.
    Experimental biology and medicine (Maywood, N.J.), 2004, Volume: 229, Issue:11

    Topics: Acetaminophen; Animals; Cardiotonic Agents; Guinea Pigs; Heart; Hypoxia; Microscopy, Electron, Transmission; Myocardial Contraction; Myocardium; Organ Culture Techniques; Peroxynitrous Acid

2004
Peroxynitrite-induced mitochondrial and endonuclease-mediated nuclear DNA damage in acetaminophen hepatotoxicity.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 315, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Apoptosis; Cell Nucleus; Chemical and Drug Induced Liver Injury; DNA Damage; DNA Fragmentation; DNA, Mitochondrial; Endonucleases; In Situ Hybridization; In Situ Nick-End Labeling; Male; Mice; Mice, Inbred C3H; Mitochondria, Liver; Peroxynitrous Acid; Subcellular Fractions; Tumor Necrosis Factor-alpha

2005
Acetaminophen attenuates peroxynitrite-activated matrix metalloproteinase-2-mediated troponin I cleavage in the isolated guinea pig myocardium.
    Journal of molecular and cellular cardiology, 2006, Volume: 40, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Guinea Pigs; Male; Matrix Metalloproteinase 2; Myocardium; Myocytes, Cardiac; Perfusion; Peroxynitrous Acid; Troponin I

2006
Double null of selenium-glutathione peroxidase-1 and copper, zinc-superoxide dismutase enhances resistance of mouse primary hepatocytes to acetaminophen toxicity.
    Experimental biology and medicine (Maywood, N.J.), 2006, Volume: 231, Issue:5

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Benzoquinones; Cell Death; Cells, Cultured; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Hepatocytes; Imines; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide; Peroxynitrous Acid; Superoxide Dismutase; Tyrosine

2006
Mice deficient in Cu,Zn-superoxide dismutase are resistant to acetaminophen toxicity.
    The Biochemical journal, 2006, Nov-01, Volume: 399, Issue:3

    Topics: Acetaminophen; Alanine Transaminase; Animals; Benzoquinones; Biotransformation; Body Weight; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Drug Resistance; Enzyme Induction; Glutathione; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Imines; Liver Failure; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxidation-Reduction; Oxidative Stress; Peroxynitrous Acid; Superoxide Dismutase; Tyrosine

2006
Quantification of nitrated tryptophan in proteins and tissues by high-performance liquid chromatography with electrospray ionization tandem mass spectrometry.
    Journal of pharmaceutical and biomedical analysis, 2007, May-09, Volume: 44, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Cattle; Chromatography, High Pressure Liquid; Isomerism; Liver; Male; Mice; Mice, Inbred Strains; Molecular Structure; Nitrates; Peroxynitrous Acid; Protein Binding; Proteins; Reproducibility of Results; Sensitivity and Specificity; Serum Albumin, Bovine; Specific Pathogen-Free Organisms; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Tryptophan

2007
Mitochondrial protection by the JNK inhibitor leflunomide rescues mice from acetaminophen-induced liver injury.
    Hepatology (Baltimore, Md.), 2007, Volume: 45, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Apoptosis; bcl-X Protein; Enzyme Inhibitors; Immunity, Innate; Isoxazoles; Leflunomide; Liver; Male; MAP Kinase Kinase 4; Mice; Mice, Inbred C57BL; Mitochondria; Necrosis; Peroxynitrous Acid; Proto-Oncogene Proteins c-bcl-2

2007
Acetaminophen inhibits prostanoid synthesis by scavenging the PGHS-activator peroxynitrite.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2008, Volume: 22, Issue:1

    Topics: Acetaminophen; Animals; Cattle; Cells, Cultured; Chromatography, High Pressure Liquid; Cyclooxygenase 1; Enzyme Activators; Free Radical Scavengers; Male; Peroxynitrous Acid; Prostaglandins; Sheep; Spectrometry, Fluorescence

2008
Mitochondrial bax translocation accelerates DNA fragmentation and cell necrosis in a murine model of acetaminophen hepatotoxicity.
    The Journal of pharmacology and experimental therapeutics, 2008, Volume: 324, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; bcl-2-Associated X Protein; Chemical and Drug Induced Liver Injury; Disease Models, Animal; DNA Fragmentation; Liver Diseases; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria, Liver; Necrosis; Peroxynitrous Acid

2008
The effects of acute acetaminophen toxicity on hepatic mRNA expression of SOD, CAT, GSH-Px, and levels of peroxynitrite, nitric oxide, reduced glutathione, and malondialdehyde in rabbit.
    Molecular and cellular biochemistry, 2009, Volume: 323, Issue:1-2

    Topics: Acetaminophen; Animals; Catalase; Glutathione; Glutathione Peroxidase; Lipid Peroxidation; Liver; Male; Malondialdehyde; Nitric Oxide; Nitrites; Peroxynitrous Acid; Rabbits; RNA; Superoxide Dismutase

2009
Novel mechanisms of protection against acetaminophen hepatotoxicity in mice by glutathione and N-acetylcysteine.
    Hepatology (Baltimore, Md.), 2010, Volume: 51, Issue:1

    Topics: Acetaminophen; Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Drug Overdose; Energy Metabolism; Glutathione; Male; Mice; Mice, Inbred C3H; Mitochondria, Liver; Peroxynitrous Acid; Reactive Oxygen Species; Up-Regulation

2010
Nitration processes of acetaminophen in nitrifying activated sludge.
    Environmental science & technology, 2010, Jan-01, Volume: 44, Issue:1

    Topics: Acetaminophen; Horseradish Peroxidase; Nitrates; Peroxynitrous Acid; Sewage

2010
c-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicity.
    Toxicology and applied pharmacology, 2010, Volume: 246, Issue:1-2

    Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Anthracenes; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Enzyme Activation; Enzyme Induction; JNK Mitogen-Activated Protein Kinases; Liver; Male; Mice; Mice, Inbred C57BL; Mitochondria, Liver; Nitric Oxide Synthase; Oxidative Stress; Peroxynitrous Acid; Phosphorylation; Reverse Transcriptase Polymerase Chain Reaction; Subcellular Fractions; Translocation, Genetic

2010
Cyclophilin D deficiency protects against acetaminophen-induced oxidant stress and liver injury.
    Free radical research, 2011, Volume: 45, Issue:2

    Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Cyclophilins; Cytochrome P-450 Enzyme System; DNA Fragmentation; Glutathione; Humans; Immunohistochemistry; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria, Liver; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Necrosis; Oxidative Stress; Peptidyl-Prolyl Isomerase F; Peroxynitrous Acid

2011
Apoptosis-inducing factor modulates mitochondrial oxidant stress in acetaminophen hepatotoxicity.
    Toxicological sciences : an official journal of the Society of Toxicology, 2011, Volume: 122, Issue:2

    Topics: Acetaminophen; Animals; Apoptosis Inducing Factor; Blotting, Western; Chemical and Drug Induced Liver Injury; DNA Fragmentation; Drug Overdose; Glutathione Disulfide; Hepatocytes; Immunohistochemistry; In Situ Nick-End Labeling; Liver; Male; Mice; Mitochondria, Liver; Necrosis; Oxidative Stress; Peroxynitrous Acid; Reactive Oxygen Species

2011
Acetaminophen overdose-induced liver injury in mice is mediated by peroxynitrite independently of the cyclophilin D-regulated permeability transition.
    Hepatology (Baltimore, Md.), 2011, Sep-02, Volume: 54, Issue:3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cyclophilins; Drug Overdose; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Peptidyl-Prolyl Isomerase F; Peroxynitrous Acid; Porphyrins

2011
The Alzheimer pandemic: is paracetamol to blame?
    Inflammation & allergy drug targets, 2014, Volume: 13, Issue:1

    Topics: Acetaminophen; Alzheimer Disease; Amyloid beta-Protein Precursor; Analgesics, Non-Narcotic; Animals; Autoantigens; Brain; History, 19th Century; History, 20th Century; History, 21st Century; Humans; Metabolic Detoxication, Phase I; Microglia; Pandemics; Peroxynitrous Acid

2014
Targeting mitochondria with methylene blue protects mice against acetaminophen-induced liver injury.
    Hepatology (Baltimore, Md.), 2015, Volume: 61, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Benzoquinones; Cell Death; Cells, Cultured; Chemical and Drug Induced Liver Injury; Drug Evaluation, Preclinical; Electron Transport Complex II; Enzyme Inhibitors; Hepatocytes; Imines; Liver; Male; Methylene Blue; Mice, Inbred C57BL; Mitochondria, Liver; Necrosis; Peroxynitrous Acid; Succinate Dehydrogenase

2015
Preparation of hydrophilic C60(OH)10/2-hydroxypropyl-β-cyclodextrin nanoparticles for the treatment of a liver injury induced by an overdose of acetaminophen.
    Biomaterials, 2015, Volume: 45

    Topics: 2-Hydroxypropyl-beta-cyclodextrin; Acetaminophen; Animals; Antioxidants; Benzothiazoles; beta-Cyclodextrins; Biphenyl Compounds; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Drug Overdose; Electron Spin Resonance Spectroscopy; Free Radical Scavengers; Fullerenes; Glutathione; Hydrophobic and Hydrophilic Interactions; Hydroxylation; Liver; Male; Mice, Inbred C57BL; Nanoparticles; Nitric Oxide; Oxidative Stress; Particle Size; Peroxynitrous Acid; Picrates; Protective Agents; Solubility; Static Electricity; Sulfonic Acids; Tyrosine

2015
Resveratrol prevents protein nitration and release of endonucleases from mitochondria during acetaminophen hepatotoxicity.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2015, Volume: 81

    Topics: Acetaminophen; Animals; Apoptosis Inducing Factor; Chemical and Drug Induced Liver Injury; DNA Fragmentation; Drug Overdose; Endonucleases; Hepatocytes; JNK Mitogen-Activated Protein Kinases; Liver; Male; Mice; Mice, Inbred C57BL; Mitochondria; Oxidative Stress; Peroxynitrous Acid; Protein Binding; Resveratrol; Stilbenes; Tyrosine

2015
Peroxynitrite Activatable NIR-II Fluorescent Molecular Probe for Drug-Induced Hepatotoxicity Monitoring.
    Analytical chemistry, 2019, 04-02, Volume: 91, Issue:7

    Topics: Acetaminophen; Animals; Biosensing Techniques; Cell Line, Tumor; Cell Survival; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Female; Fluorescence; Fluorescent Dyes; Humans; Infrared Rays; Mice; Mice, Nude; Peroxynitrous Acid

2019
A hepatocyte-targeting near-infrared ratiometric fluorescent probe for monitoring peroxynitrite during drug-induced hepatotoxicity and its remediation.
    Chemical communications (Cambridge, England), 2019, Nov-26, Volume: 55, Issue:95

    Topics: Acetaminophen; Animals; Cell Line, Tumor; Chemical and Drug Induced Liver Injury; Fluorescent Dyes; Hepatocytes; Humans; Infrared Rays; Mice; Mice, Inbred BALB C; Molecular Structure; Optical Imaging; Peroxynitrous Acid

2019
A novel highly selective fluorescent probe with new chalcone fluorophore for monitoring and imaging endogenous peroxynitrite in living cells and drug-damaged liver tissue.
    Talanta, 2020, Aug-01, Volume: 215

    Topics: Acetaminophen; Animals; Cell Survival; Chalcone; Fluorescent Dyes; Humans; Injections, Intraperitoneal; Liver; Male; MCF-7 Cells; Mice; Molecular Structure; Optical Imaging; Particle Size; Peroxynitrous Acid; Surface Properties; Tumor Cells, Cultured

2020
Real-time monitoring and accurate diagnosis of drug-induced hepatotoxicity in vivo by ratio-fluorescence and photoacoustic imaging of peroxynitrite.
    Nanoscale, 2020, May-14, Volume: 12, Issue:18

    Topics: Acetaminophen; Animals; Carbocyanines; Chemical and Drug Induced Liver Injury; Female; Fluorescence Resonance Energy Transfer; Fluorescent Dyes; Infrared Rays; Liver; Metal Nanoparticles; Mice; Mice, Inbred BALB C; Peroxynitrous Acid; Photoacoustic Techniques; Up-Regulation

2020
High-Selectivity Fluorescent Reporter toward Peroxynitrite in a Coexisting Nonalcoholic Fatty Liver and Drug-Induced Liver Diseases Model.
    Analytical chemistry, 2020, 08-18, Volume: 92, Issue:16

    Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Coumarins; Cytochrome P-450 CYP2E1; Diet, High-Fat; Fatty Acids; Fluorescent Dyes; Hep G2 Cells; Humans; Limit of Detection; Liver; Mice; Microscopy, Fluorescence; Mitochondria; Non-alcoholic Fatty Liver Disease; Peroxynitrous Acid

2020
Visualization of ONOO
    Analytical chemistry, 2020, 11-03, Volume: 92, Issue:21

    Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Electron Transport; Fluorescent Dyes; HeLa Cells; Humans; Liver; Mice; Optical Imaging; Peroxynitrous Acid; Signal-To-Noise Ratio; Viscosity

2020
A ratiometric theranostic system for visualization of ONOO
    Biomaterials science, 2022, Feb-15, Volume: 10, Issue:4

    Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Liver; Mice; Mice, Inbred C57BL; Peroxynitrous Acid; Pharmaceutical Preparations; Precision Medicine

2022
Peroxynitrite-Promoted Persulfide Prodrugs with Protective Potential against Paracetamol Poisoning.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2022, Jun-27, Volume: 28, Issue:36

    Topics: Acetaminophen; Chromatography, Liquid; Peroxynitrous Acid; Prodrugs; Sulfides; Tandem Mass Spectrometry

2022
The role of Iron in lipid peroxidation and protein nitration during acetaminophen-induced liver injury in mice.
    Toxicology and applied pharmacology, 2022, 06-15, Volume: 445

    Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Injury, Chronic; Deferoxamine; Hepatocytes; Iron; Lipid Peroxidation; Liver; Male; Mice; Mice, Inbred C57BL; Minocycline; Mitochondria, Liver; Oxidative Stress; Peroxynitrous Acid

2022
Boronate-Based Oxidant-Responsive Derivatives of Acetaminophen as Proinhibitors of Myeloperoxidase.
    Chemical research in toxicology, 2023, 08-21, Volume: 36, Issue:8

    Topics: Acetaminophen; Humans; Hydrogen Peroxide; Hypochlorous Acid; Oxidants; Oxidation-Reduction; Peroxidase; Peroxynitrous Acid

2023