peroxynitrous acid has been researched along with acetaminophen in 39 studies
Studies (peroxynitrous acid) | Trials (peroxynitrous acid) | Recent Studies (post-2010) (peroxynitrous acid) | Studies (acetaminophen) | Trials (acetaminophen) | Recent Studies (post-2010) (acetaminophen) |
---|---|---|---|---|---|
3,303 | 21 | 1,230 | 20,696 | 2,848 | 8,242 |
Protein | Taxonomy | peroxynitrous acid (IC50) | acetaminophen (IC50) |
---|---|---|---|
Myoglobin | Homo sapiens (human) | 2.3 |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 18 (46.15) | 29.6817 |
2010's | 13 (33.33) | 24.3611 |
2020's | 8 (20.51) | 2.80 |
Authors | Studies |
---|---|
Goldberg, E; Merrill, GF | 1 |
Farhood, A; Ho, YS; Jaeschke, H; Knight, TR | 1 |
Golfetti, R; Merrill, G; Rork, T; Spiler, N; VanDyke, K | 1 |
Golfetti, R; Merrill, G; Rork, T | 1 |
Bajt, ML; Jaeschke, H; Knight, TR | 1 |
Bajt, ML; Farhood, A; Jaeschke, H; Knight, TR | 1 |
Hinson, JA; Jaeschke, H; James, LP; Knight, TR; McCullough, SS | 1 |
Merrill, GF; Rork, TH; Spiler, NM; Van Dyke, K | 1 |
Bajt, ML; Cover, C; Jaeschke, H; Knight, TR; Lemasters, JJ; Mansouri, A; Pessayre, D | 1 |
Bajt, ML; Jaeschke, H | 1 |
Hadzimichalis, NM; Kappil, MA; Merrill, GF; Rork, TH | 1 |
Lei, XG; Zhu, JH | 1 |
Aregullin, M; Lei, XG; McClung, JP; Roneker, CA; Zhu, JH | 1 |
Hirose, M; Ishii, Y; Ito, R; Iwasaki, Y; Katsumata, T; Nakazawa, H; Nishikawa, A; Ogara, A; Saito, K; Umemura, T | 1 |
Boelsterli, UA; Goh, CW; Latchoumycandane, C; Ong, MM | 1 |
Bachschmid, MM; Cohen, RA; Daiber, A; Ghisla, S; Schildknecht, S | 1 |
Bajt, ML; Farhood, A; Jaeschke, H; Lemasters, JJ | 1 |
Adiguzel, K; Akgoz, M; Cigremis, Y; Karaman, M; Kart, A; Ozen, H; Turel, H | 1 |
Jaeschke, H; Saito, C; Zwingmann, C | 1 |
Chiron, S; Fenet, H; Gomez, E | 1 |
Jaeschke, H; Lemasters, JJ; Saito, C | 1 |
Baines, CP; Jaeschke, H; Lebofsky, M; Lemasters, JJ; Ramachandran, A | 1 |
Bajt, ML; Farhood, A; Jaeschke, H; Lebofsky, M; Lemasters, JJ; Ramachandran, A; Yan, HM | 1 |
Boelsterli, UA; LoGuidice, A | 1 |
Jaeschke, H; McGill, MR; Ramachandran, A | 1 |
Jones, GR | 1 |
Alder, NN; Boelsterli, UA; Chamberland, SR; Imaizumi, N; Lee, KK | 1 |
Anraku, M; Hirayama, F; Iohara, D; Irie, T; Ishitsuka, Y; Uekama, K; Umezaki, Y | 1 |
Bajt, ML; Du, K; Jaeschke, H; McGill, MR; Xie, Y | 1 |
Alhoshan, MS; El-Toni, AM; Fan, Y; Lei, Z; Li, D; Sun, C; Wang, S; Zhang, F | 1 |
Fei, J; Jiang, WL; Li, CY; Li, Y; Wang, WX; Zhao, YT | 1 |
Chen, J; Cui, M; Deng, D; Gu, Y; Ling, C; Wang, P; Xia, L | 1 |
Chen, Y; Han, X; Li, B; Wei, P; Yi, T; Yuan, W; Zhang, M; Zhao, M; Zhuang, H | 1 |
Cheng, D; Gong, X; Lv, Y; Wu, Q; Yuan, J; Yuan, L; Zhang, X | 1 |
Deng, Y; Feng, G | 1 |
Chau, JHC; Kwok, RTK; Lam, JWY; Lam, KWK; Lee, MMS; Tang, BZ; Yu, EY; Zhang, R | 1 |
Jin, HW; Wang, G; Wang, J; Xu, BX; Xu, ST; Xu, YW; Zhen, L | 1 |
Adelusi, OB; Jaeschke, H; Lemasters, JJ; Ramachandran, A | 1 |
Marcinek, A; Michalski, R; Pierzchała, K; Pięta, J; Pięta, M; Rola, M; Sikora, A; Zielonka, J | 1 |
3 review(s) available for peroxynitrous acid and acetaminophen
Article | Year |
---|---|
The role of oxidant stress and reactive nitrogen species in acetaminophen hepatotoxicity.
Topics: Acetaminophen; Adenosine Triphosphate; Analgesics, Non-Narcotic; Animals; Apoptosis; Humans; Lipid Peroxidation; Liver; Mitochondria; Models, Animal; Necrosis; Oxidative Stress; Peroxynitrous Acid; Reactive Nitrogen Species | 2003 |
Intracellular signaling mechanisms of acetaminophen-induced liver cell death.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Apoptosis; Cell Death; DNA Fragmentation; Hepatocytes; Liver; Necrosis; Peroxynitrous Acid; Signal Transduction | 2006 |
Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Antioxidants; Apoptosis; Cell Death; Chemical and Drug Induced Liver Injury; DNA Fragmentation; Humans; Inflammation; Liver; Mitochondria; Necrosis; Oxidants; Oxidative Stress; Peroxynitrous Acid; Reactive Oxygen Species | 2012 |
36 other study(ies) available for peroxynitrous acid and acetaminophen
Article | Year |
---|---|
Antioxidant properties of acetaminophen and cardioprotection.
Topics: Acetaminophen; Action Potentials; Analgesics, Non-Narcotic; Animals; Antioxidants; Cardiotonic Agents; Female; GABA Modulators; Guinea Pigs; Heart Conduction System; Hydroxyl Radical; In Vitro Techniques; Male; Myocardial Ischemia; Myocardium; Pentobarbital; Peroxynitrous Acid; Ventricular Premature Complexes | 2001 |
Peroxynitrite is a critical mediator of acetaminophen hepatotoxicity in murine livers: protection by glutathione.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Antidotes; Chemical and Drug Induced Liver Injury; Glutathione; Immunohistochemistry; Injections, Intravenous; Liver; Male; Mice; Mice, Inbred C3H; Mitochondria, Liver; Necrosis; Peroxynitrous Acid; Serum Albumin, Bovine; Tyrosine | 2002 |
Acetaminophen in the post-ischemia reperfused myocardium.
Topics: Acetaminophen; Animals; Creatine Kinase; Female; Guinea Pigs; Heart; Male; Myocardial Ischemia; Myocardial Reperfusion; Peroxynitrous Acid; Uric Acid | 2002 |
Chronically administered acetaminophen and the ischemia/reperfused myocardium.
Topics: Acetaminophen; Animals; Cardiotonic Agents; Coronary Circulation; Creatine Kinase; Female; Guinea Pigs; Heart; Luminescent Measurements; Male; Microscopy, Electron; Myocardial Ischemia; Myocardial Reperfusion Injury; Peroxynitrous Acid; Time Factors; Ventricular Function, Left | 2003 |
Scavenging peroxynitrite with glutathione promotes regeneration and enhances survival during acetaminophen-induced liver injury in mice.
Topics: Acetaminophen; Animals; Disease Models, Animal; Glutathione; Glutathione Disulfide; Immunohistochemistry; Liver Regeneration; Male; Mice; Mice, Inbred C3H; Peroxynitrous Acid; Respiratory Distress Syndrome; Survival Rate | 2003 |
Acetaminophen toxicity in mice lacking NADPH oxidase activity: role of peroxynitrite formation and mitochondrial oxidant stress.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Endothelium, Vascular; Glutathione; Glutathione Disulfide; Hepatocytes; Hydrogen Peroxide; Macrophages; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria, Liver; NADPH Oxidase 2; NADPH Oxidases; Oxidative Stress; Peroxynitrous Acid; Superoxides; Tyrosine | 2003 |
Acetaminophen in the hypoxic and reoxygenated guinea pig myocardium.
Topics: Acetaminophen; Animals; Cardiotonic Agents; Guinea Pigs; Heart; Hypoxia; Microscopy, Electron, Transmission; Myocardial Contraction; Myocardium; Organ Culture Techniques; Peroxynitrous Acid | 2004 |
Peroxynitrite-induced mitochondrial and endonuclease-mediated nuclear DNA damage in acetaminophen hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Apoptosis; Cell Nucleus; Chemical and Drug Induced Liver Injury; DNA Damage; DNA Fragmentation; DNA, Mitochondrial; Endonucleases; In Situ Hybridization; In Situ Nick-End Labeling; Male; Mice; Mice, Inbred C3H; Mitochondria, Liver; Peroxynitrous Acid; Subcellular Fractions; Tumor Necrosis Factor-alpha | 2005 |
Acetaminophen attenuates peroxynitrite-activated matrix metalloproteinase-2-mediated troponin I cleavage in the isolated guinea pig myocardium.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Guinea Pigs; Male; Matrix Metalloproteinase 2; Myocardium; Myocytes, Cardiac; Perfusion; Peroxynitrous Acid; Troponin I | 2006 |
Double null of selenium-glutathione peroxidase-1 and copper, zinc-superoxide dismutase enhances resistance of mouse primary hepatocytes to acetaminophen toxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Benzoquinones; Cell Death; Cells, Cultured; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Hepatocytes; Imines; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide; Peroxynitrous Acid; Superoxide Dismutase; Tyrosine | 2006 |
Mice deficient in Cu,Zn-superoxide dismutase are resistant to acetaminophen toxicity.
Topics: Acetaminophen; Alanine Transaminase; Animals; Benzoquinones; Biotransformation; Body Weight; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Drug Resistance; Enzyme Induction; Glutathione; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Imines; Liver Failure; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxidation-Reduction; Oxidative Stress; Peroxynitrous Acid; Superoxide Dismutase; Tyrosine | 2006 |
Quantification of nitrated tryptophan in proteins and tissues by high-performance liquid chromatography with electrospray ionization tandem mass spectrometry.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Cattle; Chromatography, High Pressure Liquid; Isomerism; Liver; Male; Mice; Mice, Inbred Strains; Molecular Structure; Nitrates; Peroxynitrous Acid; Protein Binding; Proteins; Reproducibility of Results; Sensitivity and Specificity; Serum Albumin, Bovine; Specific Pathogen-Free Organisms; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Tryptophan | 2007 |
Mitochondrial protection by the JNK inhibitor leflunomide rescues mice from acetaminophen-induced liver injury.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Apoptosis; bcl-X Protein; Enzyme Inhibitors; Immunity, Innate; Isoxazoles; Leflunomide; Liver; Male; MAP Kinase Kinase 4; Mice; Mice, Inbred C57BL; Mitochondria; Necrosis; Peroxynitrous Acid; Proto-Oncogene Proteins c-bcl-2 | 2007 |
Acetaminophen inhibits prostanoid synthesis by scavenging the PGHS-activator peroxynitrite.
Topics: Acetaminophen; Animals; Cattle; Cells, Cultured; Chromatography, High Pressure Liquid; Cyclooxygenase 1; Enzyme Activators; Free Radical Scavengers; Male; Peroxynitrous Acid; Prostaglandins; Sheep; Spectrometry, Fluorescence | 2008 |
Mitochondrial bax translocation accelerates DNA fragmentation and cell necrosis in a murine model of acetaminophen hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; bcl-2-Associated X Protein; Chemical and Drug Induced Liver Injury; Disease Models, Animal; DNA Fragmentation; Liver Diseases; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria, Liver; Necrosis; Peroxynitrous Acid | 2008 |
The effects of acute acetaminophen toxicity on hepatic mRNA expression of SOD, CAT, GSH-Px, and levels of peroxynitrite, nitric oxide, reduced glutathione, and malondialdehyde in rabbit.
Topics: Acetaminophen; Animals; Catalase; Glutathione; Glutathione Peroxidase; Lipid Peroxidation; Liver; Male; Malondialdehyde; Nitric Oxide; Nitrites; Peroxynitrous Acid; Rabbits; RNA; Superoxide Dismutase | 2009 |
Novel mechanisms of protection against acetaminophen hepatotoxicity in mice by glutathione and N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Drug Overdose; Energy Metabolism; Glutathione; Male; Mice; Mice, Inbred C3H; Mitochondria, Liver; Peroxynitrous Acid; Reactive Oxygen Species; Up-Regulation | 2010 |
Nitration processes of acetaminophen in nitrifying activated sludge.
Topics: Acetaminophen; Horseradish Peroxidase; Nitrates; Peroxynitrous Acid; Sewage | 2010 |
c-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicity.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Anthracenes; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Enzyme Activation; Enzyme Induction; JNK Mitogen-Activated Protein Kinases; Liver; Male; Mice; Mice, Inbred C57BL; Mitochondria, Liver; Nitric Oxide Synthase; Oxidative Stress; Peroxynitrous Acid; Phosphorylation; Reverse Transcriptase Polymerase Chain Reaction; Subcellular Fractions; Translocation, Genetic | 2010 |
Cyclophilin D deficiency protects against acetaminophen-induced oxidant stress and liver injury.
Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Cyclophilins; Cytochrome P-450 Enzyme System; DNA Fragmentation; Glutathione; Humans; Immunohistochemistry; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria, Liver; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Necrosis; Oxidative Stress; Peptidyl-Prolyl Isomerase F; Peroxynitrous Acid | 2011 |
Apoptosis-inducing factor modulates mitochondrial oxidant stress in acetaminophen hepatotoxicity.
Topics: Acetaminophen; Animals; Apoptosis Inducing Factor; Blotting, Western; Chemical and Drug Induced Liver Injury; DNA Fragmentation; Drug Overdose; Glutathione Disulfide; Hepatocytes; Immunohistochemistry; In Situ Nick-End Labeling; Liver; Male; Mice; Mitochondria, Liver; Necrosis; Oxidative Stress; Peroxynitrous Acid; Reactive Oxygen Species | 2011 |
Acetaminophen overdose-induced liver injury in mice is mediated by peroxynitrite independently of the cyclophilin D-regulated permeability transition.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cyclophilins; Drug Overdose; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Peptidyl-Prolyl Isomerase F; Peroxynitrous Acid; Porphyrins | 2011 |
The Alzheimer pandemic: is paracetamol to blame?
Topics: Acetaminophen; Alzheimer Disease; Amyloid beta-Protein Precursor; Analgesics, Non-Narcotic; Animals; Autoantigens; Brain; History, 19th Century; History, 20th Century; History, 21st Century; Humans; Metabolic Detoxication, Phase I; Microglia; Pandemics; Peroxynitrous Acid | 2014 |
Targeting mitochondria with methylene blue protects mice against acetaminophen-induced liver injury.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Benzoquinones; Cell Death; Cells, Cultured; Chemical and Drug Induced Liver Injury; Drug Evaluation, Preclinical; Electron Transport Complex II; Enzyme Inhibitors; Hepatocytes; Imines; Liver; Male; Methylene Blue; Mice, Inbred C57BL; Mitochondria, Liver; Necrosis; Peroxynitrous Acid; Succinate Dehydrogenase | 2015 |
Preparation of hydrophilic C60(OH)10/2-hydroxypropyl-β-cyclodextrin nanoparticles for the treatment of a liver injury induced by an overdose of acetaminophen.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Acetaminophen; Animals; Antioxidants; Benzothiazoles; beta-Cyclodextrins; Biphenyl Compounds; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Drug Overdose; Electron Spin Resonance Spectroscopy; Free Radical Scavengers; Fullerenes; Glutathione; Hydrophobic and Hydrophilic Interactions; Hydroxylation; Liver; Male; Mice, Inbred C57BL; Nanoparticles; Nitric Oxide; Oxidative Stress; Particle Size; Peroxynitrous Acid; Picrates; Protective Agents; Solubility; Static Electricity; Sulfonic Acids; Tyrosine | 2015 |
Resveratrol prevents protein nitration and release of endonucleases from mitochondria during acetaminophen hepatotoxicity.
Topics: Acetaminophen; Animals; Apoptosis Inducing Factor; Chemical and Drug Induced Liver Injury; DNA Fragmentation; Drug Overdose; Endonucleases; Hepatocytes; JNK Mitogen-Activated Protein Kinases; Liver; Male; Mice; Mice, Inbred C57BL; Mitochondria; Oxidative Stress; Peroxynitrous Acid; Protein Binding; Resveratrol; Stilbenes; Tyrosine | 2015 |
Peroxynitrite Activatable NIR-II Fluorescent Molecular Probe for Drug-Induced Hepatotoxicity Monitoring.
Topics: Acetaminophen; Animals; Biosensing Techniques; Cell Line, Tumor; Cell Survival; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Female; Fluorescence; Fluorescent Dyes; Humans; Infrared Rays; Mice; Mice, Nude; Peroxynitrous Acid | 2019 |
A hepatocyte-targeting near-infrared ratiometric fluorescent probe for monitoring peroxynitrite during drug-induced hepatotoxicity and its remediation.
Topics: Acetaminophen; Animals; Cell Line, Tumor; Chemical and Drug Induced Liver Injury; Fluorescent Dyes; Hepatocytes; Humans; Infrared Rays; Mice; Mice, Inbred BALB C; Molecular Structure; Optical Imaging; Peroxynitrous Acid | 2019 |
A novel highly selective fluorescent probe with new chalcone fluorophore for monitoring and imaging endogenous peroxynitrite in living cells and drug-damaged liver tissue.
Topics: Acetaminophen; Animals; Cell Survival; Chalcone; Fluorescent Dyes; Humans; Injections, Intraperitoneal; Liver; Male; MCF-7 Cells; Mice; Molecular Structure; Optical Imaging; Particle Size; Peroxynitrous Acid; Surface Properties; Tumor Cells, Cultured | 2020 |
Real-time monitoring and accurate diagnosis of drug-induced hepatotoxicity in vivo by ratio-fluorescence and photoacoustic imaging of peroxynitrite.
Topics: Acetaminophen; Animals; Carbocyanines; Chemical and Drug Induced Liver Injury; Female; Fluorescence Resonance Energy Transfer; Fluorescent Dyes; Infrared Rays; Liver; Metal Nanoparticles; Mice; Mice, Inbred BALB C; Peroxynitrous Acid; Photoacoustic Techniques; Up-Regulation | 2020 |
High-Selectivity Fluorescent Reporter toward Peroxynitrite in a Coexisting Nonalcoholic Fatty Liver and Drug-Induced Liver Diseases Model.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Coumarins; Cytochrome P-450 CYP2E1; Diet, High-Fat; Fatty Acids; Fluorescent Dyes; Hep G2 Cells; Humans; Limit of Detection; Liver; Mice; Microscopy, Fluorescence; Mitochondria; Non-alcoholic Fatty Liver Disease; Peroxynitrous Acid | 2020 |
Visualization of ONOO
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Electron Transport; Fluorescent Dyes; HeLa Cells; Humans; Liver; Mice; Optical Imaging; Peroxynitrous Acid; Signal-To-Noise Ratio; Viscosity | 2020 |
A ratiometric theranostic system for visualization of ONOO
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Liver; Mice; Mice, Inbred C57BL; Peroxynitrous Acid; Pharmaceutical Preparations; Precision Medicine | 2022 |
Peroxynitrite-Promoted Persulfide Prodrugs with Protective Potential against Paracetamol Poisoning.
Topics: Acetaminophen; Chromatography, Liquid; Peroxynitrous Acid; Prodrugs; Sulfides; Tandem Mass Spectrometry | 2022 |
The role of Iron in lipid peroxidation and protein nitration during acetaminophen-induced liver injury in mice.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Injury, Chronic; Deferoxamine; Hepatocytes; Iron; Lipid Peroxidation; Liver; Male; Mice; Mice, Inbred C57BL; Minocycline; Mitochondria, Liver; Oxidative Stress; Peroxynitrous Acid | 2022 |
Boronate-Based Oxidant-Responsive Derivatives of Acetaminophen as Proinhibitors of Myeloperoxidase.
Topics: Acetaminophen; Humans; Hydrogen Peroxide; Hypochlorous Acid; Oxidants; Oxidation-Reduction; Peroxidase; Peroxynitrous Acid | 2023 |