Page last updated: 2024-09-03

perospirone and haloperidol

perospirone has been researched along with haloperidol in 13 studies

Compound Research Comparison

Studies
(perospirone)
Trials
(perospirone)
Recent Studies (post-2010)
(perospirone)
Studies
(haloperidol)
Trials
(haloperidol)
Recent Studies (post-2010) (haloperidol)
111242620,3301,7533,294

Protein Interaction Comparison

ProteinTaxonomyperospirone (IC50)haloperidol (IC50)
Adenylate cyclase type 1 Rattus norvegicus (Norway rat)2.3
Voltage-dependent L-type calcium channel subunit alpha-1CCavia porcellus (domestic guinea pig)1.7
Voltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)1.5
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)1.6765
Potassium channel subfamily K member 2Homo sapiens (human)5.5
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)1.836
ATP-dependent translocase ABCB1Homo sapiens (human)5.3
Muscarinic acetylcholine receptor M1Rattus norvegicus (Norway rat)0.054
Muscarinic acetylcholine receptor M3Rattus norvegicus (Norway rat)0.054
Muscarinic acetylcholine receptor M4Rattus norvegicus (Norway rat)0.054
Cytochrome P450 3A4Homo sapiens (human)0.055
5-hydroxytryptamine receptor 1AHomo sapiens (human)1.5
5-hydroxytryptamine receptor 2CRattus norvegicus (Norway rat)0.1754
Muscarinic acetylcholine receptor M5Rattus norvegicus (Norway rat)0.054
Muscarinic acetylcholine receptor M5Homo sapiens (human)3.89
Alpha-2A adrenergic receptorHomo sapiens (human)4.973
Beta-2 adrenergic receptorRattus norvegicus (Norway rat)2.3
Muscarinic acetylcholine receptor M2Rattus norvegicus (Norway rat)0.054
Muscarinic acetylcholine receptor M1Homo sapiens (human)5.5
Cytochrome P450 2C9 Homo sapiens (human)4.69
Angiotensin-converting enzymeOryctolagus cuniculus (rabbit)7
D(2) dopamine receptorHomo sapiens (human)0.0897
5-hydroxytryptamine receptor 2ARattus norvegicus (Norway rat)0.1467
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)0.0852
Alpha-2B adrenergic receptorHomo sapiens (human)1.354
Alpha-2C adrenergic receptorHomo sapiens (human)1.845
DRattus norvegicus (Norway rat)0.1103
D(3) dopamine receptorRattus norvegicus (Norway rat)0.0067
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)4.3045
D(2) dopamine receptorBos taurus (cattle)0.1332
D(1A) dopamine receptorHomo sapiens (human)0.0575
D(4) dopamine receptorHomo sapiens (human)0.0978
D(1B) dopamine receptorHomo sapiens (human)0.005
Adenylate cyclase type 3Rattus norvegicus (Norway rat)2.3
Alpha-1D adrenergic receptorRattus norvegicus (Norway rat)0.0852
Sodium-dependent noradrenaline transporter Homo sapiens (human)1.836
Histamine H2 receptorHomo sapiens (human)1.166
Alpha-1D adrenergic receptorHomo sapiens (human)0.084
D(1B) dopamine receptorRattus norvegicus (Norway rat)0.0067
Adenylate cyclase type 2Rattus norvegicus (Norway rat)2.3
Adenylate cyclase type 4Rattus norvegicus (Norway rat)2.3
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.1815
5-hydroxytryptamine receptor 2CHomo sapiens (human)3.347
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)0.018
5-hydroxytryptamine receptor 1DRattus norvegicus (Norway rat)0.018
D(4) dopamine receptorRattus norvegicus (Norway rat)0.0067
5-hydroxytryptamine receptor 1FRattus norvegicus (Norway rat)0.018
5-hydroxytryptamine receptor 2BRattus norvegicus (Norway rat)0.1754
Sodium-dependent serotonin transporterHomo sapiens (human)3.386
Histamine H1 receptorHomo sapiens (human)2.781
Mu-type opioid receptorHomo sapiens (human)2.443
D(3) dopamine receptorHomo sapiens (human)0.0065
Sodium channel protein type 1 subunit alphaHomo sapiens (human)7
Sodium channel protein type 4 subunit alphaHomo sapiens (human)7
Adenylate cyclase type 8Rattus norvegicus (Norway rat)2.3
5-hydroxytryptamine receptor 2BHomo sapiens (human)2.05
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)0.0852
Cytochrome P450 2J2Homo sapiens (human)4.69
D(2) dopamine receptorRattus norvegicus (Norway rat)0.0129
N-acetyltransferase EisMycobacterium tuberculosis H37Rv0.39
Sodium channel protein type 7 subunit alphaHomo sapiens (human)7
Voltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)1.5
Adenylate cyclase type 6Rattus norvegicus (Norway rat)2.3
Adenylate cyclase type 5Rattus norvegicus (Norway rat)1.425
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)0.2634
Voltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)1.5
Voltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)1.5
Sodium channel protein type 5 subunit alphaHomo sapiens (human)7
Sodium channel protein type 9 subunit alphaHomo sapiens (human)7
Adenylyl cyclase 7 Rattus norvegicus (Norway rat)2.3
DBos taurus (cattle)0.2509
Sodium channel protein type 2 subunit alphaHomo sapiens (human)7
Sigma non-opioid intracellular receptor 1Homo sapiens (human)0.07
Sodium channel protein type 3 subunit alphaHomo sapiens (human)7
Sigma non-opioid intracellular receptor 1Rattus norvegicus (Norway rat)0.0013
Sodium channel protein type 11 subunit alphaHomo sapiens (human)7
Sodium channel protein type 8 subunit alphaHomo sapiens (human)7
Sodium channel protein type 10 subunit alphaHomo sapiens (human)7

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's9 (69.23)18.2507
2000's3 (23.08)29.6817
2010's1 (7.69)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Andrieux, M; Besançon, R; Giros, B; Martres, MP; Pilon, C; Schwartz, JC; Sokoloff, P1
Ikeda, K; Ishibashi, T; Ishida, K; Kato, T; Nakamura, M; Ohno, Y1
Hirose, A; Kato, T; Maruoka, Y; Nakamura, M; Ohno, Y; Tatsuno, T1
Antoku, F; Ishizumi, K; Kojima, A; Saji, I; Yoshigi, M1
Ishibashi, T; Ishida, K; Nakamura, M; Ohno, Y; Okada, K1
Ikeda, K; Ishibashi, T; Ishida, K; Nakamura, M; Ohno, Y; Tojima, R; Yasui, J1
Ishibashi, T; Ishida, K; Nakamura, M; Ohno, Y1
Ishibashi, T; Ishida-Tokuda, K; Nakamura, M; Ohno, Y1
Matsumoto, K; Nakamura, M; Ohno, Y; Sakamoto, H1
Ito, C; Ojima, T; Sakurai, E; Watanabe, T; Yanai, K1
Egashira, N; Fujiwara, M; Harada, S; Iwasaki, K; Matsushita, M; Mishima, K; Nishimura, R; Okuno, R1
Dierks, T; Irisawa, S; Isotani, T; Kikuchi, M; Kinoshita, T; Koenig, T; Okugawa, G; Strik, W; Yagyu, T; Yamada, K; Yoshimura, M1
Fukui, N; Ono, S; Saito, M; Someya, T; Sugai, T; Suzuki, Y; Tsuneyama, N; Watanabe, J1

Trials

1 trial(s) available for perospirone and haloperidol

ArticleYear
A pharmaco-EEG study on antipsychotic drugs in healthy volunteers.
    Psychopharmacology, 2007, Volume: 191, Issue:4

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chlorpromazine; Cross-Over Studies; Dibenzothiazepines; Electroencephalography; Fourier Analysis; Haloperidol; Humans; Indoles; Isoindoles; Male; Olanzapine; Quetiapine Fumarate; Reference Values; Risperidone; Single-Blind Method; Thiazoles; Time Factors

2007

Other Studies

12 other study(ies) available for perospirone and haloperidol

ArticleYear
Pharmacology of human dopamine D3 receptor expressed in a mammalian cell line: comparison with D2 receptor.
    European journal of pharmacology, 1992, Apr-10, Volume: 225, Issue:4

    Topics: Animals; Chlorides; CHO Cells; Cricetinae; Dopamine; Dopamine Agents; Dopamine Antagonists; Guanylyl Imidodiphosphate; Humans; Lithium; Lithium Chloride; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D3; Sodium Chloride; Sulpiride; Transfection

1992
Effects of chronic treatments with SM-9018, a potential atypical neuroleptic, on behavioral dopaminergic and serotonergic sensitivities in rats.
    General pharmacology, 1995, Volume: 26, Issue:3

    Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Dopamine; Haloperidol; Indoles; Isoindoles; Male; Motor Activity; Posture; Rats; Rats, Sprague-Dawley; Serotonin; Stereotyped Behavior; Thiazoles

1995
Effects of SM-9018, a potential atypical neuroleptic, on the central monoaminergic system in rats.
    Japanese journal of pharmacology, 1993, Volume: 62, Issue:4

    Topics: Animals; Antipsychotic Agents; Biogenic Monoamines; Brain Chemistry; Chromatography, High Pressure Liquid; Dopamine; Electrochemistry; Haloperidol; In Vitro Techniques; Indoles; Isoindoles; Kinetics; Male; Norepinephrine; Rats; Rats, Sprague-Dawley; Serotonin; Thiazoles

1993
Succinimide derivatives. II. Synthesis and antipsychotic activity of N-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]-1,2-cis- cyclohexanedicarboximide (SM-9018) and related compounds.
    Chemical & pharmaceutical bulletin, 1995, Volume: 43, Issue:12

    Topics: Animals; Antipsychotic Agents; Behavior, Animal; Catalepsy; Central Nervous System Depressants; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Haloperidol; In Vitro Techniques; Indoles; Isoindoles; Mice; Motor Activity; Neostriatum; Psychotropic Drugs; Rats; Serotonin Antagonists; Spiro Compounds; Stereotyped Behavior; Structure-Activity Relationship; Succinimides; Thiazoles

1995
Effects of subchronic treatments with SM-9018, a novel 5-HT2 and D2 antagonist, on dopamine and 5-HT receptors in rats.
    Progress in neuro-psychopharmacology & biological psychiatry, 1995, Volume: 19, Issue:6

    Topics: Animals; Antipsychotic Agents; Binding, Competitive; Haloperidol; Indoles; Isoindoles; Male; Raclopride; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Serotonin; Salicylamides; Serotonin Antagonists; Thiazoles; Up-Regulation

1995
Contrasting effects of SM-9018, a potential atypical antipsychotic, and haloperidol on c-fos mRNA expression in the rat striatum.
    European journal of pharmacology, 1996, May-15, Volume: 303, Issue:3

    Topics: Animals; Antipsychotic Agents; Corpus Striatum; Gene Expression; Genes, fos; Haloperidol; Indoles; Isoindoles; Male; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; RNA, Messenger; Serotonin Antagonists; Thiazoles

1996
Effects of SM-9018, a novel 5-HT2 and D2 receptor antagonist, on electrically-evoked [3H]acetylcholine release from rat striatal slices.
    General pharmacology, 1996, Volume: 27, Issue:7

    Topics: Acetylcholine; Animals; Antipsychotic Agents; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Electric Stimulation; Haloperidol; In Vitro Techniques; Indoles; Isoindoles; Male; Neostriatum; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Serotonin Antagonists; Thiazoles

1996
Effects of perospirone (SM-9018), a potential atypical neuroleptic, on dopamine D1 receptor-mediated vacuous chewing movement in rats: a role of 5-HT2 receptor blocking activity.
    Pharmacology, biochemistry, and behavior, 1997, Volume: 57, Issue:4

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Antipsychotic Agents; Avoidance Learning; Dopamine Agonists; Dopamine Antagonists; Dyskinesia, Drug-Induced; Haloperidol; Indoles; Isoindoles; Male; Mastication; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Thiazoles

1997
Anxiolytic-like effects of perospirone, a novel serotonin-2 and dopamine-2 antagonist (SDA)-type antipsychotic agent.
    Pharmacology, biochemistry, and behavior, 1998, Volume: 60, Issue:4

    Topics: Aggression; Animals; Anti-Anxiety Agents; Antipsychotic Agents; Diazepam; Dopamine Antagonists; Dose-Response Relationship, Drug; Haloperidol; Indoles; Interpersonal Relations; Isoindoles; Male; Rats; Serotonin Antagonists; Thiazoles

1998
Effects of serotonin-dopamine antagonists on prepulse inhibition and neurotransmitter contents in the rat cortex.
    Neuroscience letters, 2004, Aug-12, Volume: 366, Issue:2

    Topics: Animals; Antipsychotic Agents; Cerebral Cortex; Cognition; Dopamine; Dopamine Antagonists; Haloperidol; Indoles; Isoindoles; Male; Neurotransmitter Agents; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reflex, Startle; Risperidone; Serotonin; Serotonin Antagonists; Thiazoles

2004
Perospirone, a novel antipsychotic drug, inhibits marble-burying behavior via 5-HT1A receptor in mice: implications for obsessive-compulsive disorder.
    Journal of pharmacological sciences, 2005, Volume: 99, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Haloperidol; Indoles; Isoindoles; Male; Mice; Mice, Inbred ICR; Motor Activity; Obsessive-Compulsive Disorder; Piperazines; Receptor, Serotonin, 5-HT1A; Risperidone; Serotonin Antagonists; Serotonin Receptor Agonists; Thiazoles

2005
Improvement in QTc prolongation induced by zotepine following a switch to perospirone.
    Psychiatry and clinical neurosciences, 2012, Volume: 66, Issue:3

    Topics: Antipsychotic Agents; Dibenzothiepins; Electrocardiography; Female; Haloperidol; Heart Rate; Humans; Isoindoles; Long QT Syndrome; Middle Aged; Schizophrenia; Thiazoles; Water-Electrolyte Imbalance

2012