Page last updated: 2024-08-21

perillyl alcohol and temozolomide

perillyl alcohol has been researched along with temozolomide in 8 studies

Research

Studies (8)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (12.50)	29.6817
2010's	6 (75.00)	24.3611
2020's	1 (12.50)	2.80

Authors

Authors	Studies
da Fonseca, CO; Fischer, J; Futuro, D; Gattass, CR; Nagel, J; Quirico-Santos, T; Schwartsmann, G	1
Chen, TC; Cho, HY; Goldkorn, A; Hofman, FM; Jhaveri, N; Lee, DJ; Leong, MN; Louie, SG; Petasis, NA; Schönthal, AH; Torres, S; Tseng, J; Wang, W; Xu, T	1
Barath, M; Chen, TC; Cho, HY; Hofman, FM; Schönthal, AH; Sharma, N; Wang, W	1
Chen, TC; Guo, W; Li, Y; Lv, L; Song, X; Wang, W; Wang, X; Wei, L; Xie, L	1
Chen, TC; Song, X; Wang, W; Wang, X; Xie, L; Zeng, Q	1
Chang, M; Chen, TC; Geng, X; Song, X; Wang, X; Xie, L	1
Chang, M; Chen, TC; Geng, X; Song, X; Wang, W; Wang, X; Xie, L	1
Chen, TC; Cho, HY; Fu, J; Hofman, FM; Minea, RO; Ou, M; Schönthal, AH; Stathopoulos, A; Swenson, SD; Tang, L; Thein, TZ; Wang, W	1

Trials

1 trial(s) available for perillyl alcohol and temozolomide

Article	Year
Preliminary results from a phase I/II study of perillyl alcohol intranasal administration in adults with recurrent malignant gliomas. Surgical neurology, 2008, Volume: 70, Issue:3 Topics: Administration, Intranasal; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Blood-Brain Barrier; Brain Neoplasms; Dacarbazine; Disease Progression; Drug Administration Schedule; Enzyme Inhibitors; Female; Glioma; Humans; Magnetic Resonance Imaging; Male; Monoterpenes; Neoplasm Recurrence, Local; Oncogene Protein p21(ras); Signal Transduction; Survival Rate; Temozolomide; Transforming Growth Factor beta; Treatment Outcome	2008

Article

Year

Preliminary results from a phase I/II study of perillyl alcohol intranasal administration in adults with recurrent malignant gliomas.

Surgical neurology, 2008, Volume: 70, Issue:3

Topics: Administration, Intranasal; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Blood-Brain Barrier; Brain Neoplasms; Dacarbazine; Disease Progression; Drug Administration Schedule; Enzyme Inhibitors; Female; Glioma; Humans; Magnetic Resonance Imaging; Male; Monoterpenes; Neoplasm Recurrence, Local; Oncogene Protein p21(ras); Signal Transduction; Survival Rate; Temozolomide; Transforming Growth Factor beta; Treatment Outcome

2008

Other Studies

7 other study(ies) available for perillyl alcohol and temozolomide

Article	Year
Perillyl alcohol for the treatment of temozolomide-resistant gliomas. Molecular cancer therapeutics, 2012, Volume: 11, Issue:11 Topics: Administration, Intranasal; Animals; Brain Neoplasms; Cell Death; Cell Line, Tumor; Cell Proliferation; Cytokines; Dacarbazine; Drug Resistance, Neoplasm; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Glioma; Humans; Mice; Monoterpenes; Nelfinavir; Neoplasm Invasiveness; Neovascularization, Pathologic; Pyrazoles; Sulfonamides; Temozolomide; Xenograft Model Antitumor Assays	2012
A novel temozolomide-perillyl alcohol conjugate exhibits superior activity against breast cancer cells in vitro and intracranial triple-negative tumor growth in vivo. Molecular cancer therapeutics, 2014, Volume: 13, Issue:5 Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Dacarbazine; Disease Models, Animal; DNA Modification Methylases; DNA Repair Enzymes; Drug Combinations; Drug Resistance, Neoplasm; Humans; Mice; Monoterpenes; Temozolomide; Triple Negative Breast Neoplasms; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays	2014
Therapeutic effect of TMZ-POH on human nasopharyngeal carcinoma depends on reactive oxygen species accumulation. Oncotarget, 2016, Jan-12, Volume: 7, Issue:2 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dacarbazine; Drug Synergism; Enzyme Activation; Female; G2 Phase Cell Cycle Checkpoints; Humans; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Mice, Inbred BALB C; Mice, Nude; Monoterpenes; Nasopharyngeal Neoplasms; Poly(ADP-ribose) Polymerases; Reactive Oxygen Species; Temozolomide; Tumor Burden; Xenograft Model Antitumor Assays	2016
Temozolomide-perillyl alcohol conjugate induced reactive oxygen species accumulation contributes to its cytotoxicity against non-small cell lung cancer. Scientific reports, 2016, Mar-07, Volume: 6 Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dacarbazine; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Monoterpenes; Reactive Oxygen Species; Temozolomide	2016
Temozolomide-perillyl alcohol conjugate downregulates O Cell death & disease, 2018, 02-09, Volume: 9, Issue:2 Topics: A549 Cells; Antineoplastic Agents, Alkylating; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; DNA Modification Methylases; DNA Repair Enzymes; Down-Regulation; Humans; Lung Neoplasms; Monoterpenes; Proteasome Endopeptidase Complex; Temozolomide; Tumor Suppressor Proteins; Ubiquitination	2018
Temozolomide-Perillyl alcohol conjugate impairs Mitophagy flux by inducing lysosomal dysfunction in non-small cell lung Cancer cells and sensitizes them to irradiation. Journal of experimental & clinical cancer research : CR, 2018, Oct-16, Volume: 37, Issue:1 Topics: Antineoplastic Agents, Alkylating; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Humans; Lung Neoplasms; Lysosomes; Mitophagy; Monoterpenes; Radiation-Sensitizing Agents; Temozolomide	2018
Inhibition of autophagy and induction of glioblastoma cell death by NEO214, a perillyl alcohol-rolipram conjugate. Autophagy, 2023, Volume: 19, Issue:12 Topics: Autophagy; Cell Death; Chloroquine; Glioblastoma; Glioma; Humans; Lysosomes; Monoterpenes; Rolipram; Sirolimus; Temozolomide; TOR Serine-Threonine Kinases	2023