Page last updated: 2024-08-21

perillyl alcohol and limonene

perillyl alcohol has been researched along with limonene in 33 studies

Research

Studies (33)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's11 (33.33)18.2507
2000's7 (21.21)29.6817
2010's12 (36.36)24.3611
2020's3 (9.09)2.80

Authors

AuthorsStudies
Hohl, RJ; Lewis, K1
Esson, K; Gelb, MH; Ghomashchi, F; Gould, MN; Tamanoi, F; Yokoyama, K1
Gould, MN; Haag, JD1
Chen, GZ; Luján, HD; Mowatt, MR; Nash, TE1
O'Shaughnessy, JA1
Borg-Karlson, AK; Karlson, J; Linder, S; Ringborg, U; Shoshan, MC; Unelius, R; Wilking, N1
Branch, SK; Broitman, SA; Cerda, S; Wilkinson, J1
Burke, YD; Crowell, PL; Siar Ayoubi, A1
Hohl, RJ; Lewis, KA1
Bardon, S; Martel, P; Picard, K1
Crowell, PL1
Miyazawa, M; Shimada, T; Shindo, M2
Daneri-Navarro, A; Del Toro-Arreola, A; Del Toro-Arreola, S; Flores-Torales, E; Guadalupe Ramirez-Dueñas, M; Torres-Lozano, C; Tostado-Pelayo, K1
Bauer, U; Duetz, WA; Holtackers, R; Lüscher, D; van Beilen, JB; Witholt, B1
Bisson, JF; d'Alessio, P; Menut, C1
Fukumoto, S; Yokogoshi, H; Zhou, W1
Kim, D; Ortiz de Montellano, PR1
Bühler, B; Cornelissen, S; Deshmukh, AT; Liu, S; Schmid, A1
Antonovici, M; Hauer, B; Pleiss, J; Seifert, A1
Amiot, A; Duelund, L; Fillon, A; Mouritsen, OG1
Bühler, B; Cornelissen, S; Julsing, MK; Riechert, O; Schmid, A; Volmer, J1
Adams, PD; Alonso-Gutierrez, J; Batth, TS; Chan, R; Keasling, JD; Lee, TS; Petzold, CJ1
Béné, MC; Bisson, JF; d'Alessio, PA1
Bene, MC; Bisson, JF; d'Alessio, PA; Mirshahi, M1
Wróblewska, A1
Göen, T; Schmidt, L1
Fujiwara, Y; Ito, M1
Cardoso-Teixeira, AC; Coelho-de-Souza, AN; Ferreira-da-Silva, FW; Leal-Cardoso, JH; Oliveira-Abreu, K; Peixoto-Neves, D; Pereira-Gonçalves, Á1
Adu-Frimpong, M; Mukhtar, YM; Xu, X; Yu, J1
Almeida, RS; Araújo-Filho, HG; Douglas Melo Coutinho, H; Gandhi, SR; Grougnet, R; Guedes da Silva Almeida, JR; Heimfarth, L; Martins, N; Pereira, EWM; Picot, L; Quintans, JSS; Quintans-Júnior, LJ; Santos Passos, FR; Siqueira-Lima, P; Souza Monteiro, B; Viana Dos Santos, MR1
Dong, X; Sun, C; Xie, C; Zhang, R1
da Silva, CEH; de Andrade, SF; Gosmann, G1

Reviews

4 review(s) available for perillyl alcohol and limonene

ArticleYear
Antitumorigenic effects of limonene and perillyl alcohol against pancreatic and breast cancer.
    Advances in experimental medicine and biology, 1996, Volume: 401

    Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents; Breast Neoplasms; Cyclohexenes; Dietary Fats, Unsaturated; Drug Screening Assays, Antitumor; Humans; Limonene; Monoterpenes; Pancreatic Neoplasms; Terpenes

1996
Prevention and therapy of cancer by dietary monoterpenes.
    The Journal of nutrition, 1999, Volume: 129, Issue:3

    Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents; Cyclohexenes; Diet; Limonene; Monoterpenes; Neoplasms, Experimental; Rats; Terpenes

1999
Biochemical significance of limonene and its metabolites: future prospects for designing and developing highly potent anticancer drugs.
    Bioscience reports, 2018, 12-21, Volume: 38, Issue:6

    Topics: Cyclohexenes; Drug Design; Humans; Limonene; Methyl Ethers; Monoterpenes; Neoplasms

2018
Limonene and Perillyl Alcohol Derivatives: Synthesis and Anticancer Activity.
    Mini reviews in medicinal chemistry, 2021, Volume: 21, Issue:14

    Topics: Antineoplastic Agents; Carbohydrates; Cell Survival; Humans; Limonene; Monoterpenes; Neoplasms; Structure-Activity Relationship; Thiosemicarbazones

2021

Other Studies

29 other study(ies) available for perillyl alcohol and limonene

ArticleYear
Differential effects of monoterpenes and lovastatin on RAS processing.
    The Journal of biological chemistry, 1995, Jul-21, Volume: 270, Issue:29

    Topics: Cells, Cultured; Cyclohexenes; Humans; Limonene; Lovastatin; Methionine; Monoterpenes; ras Proteins; Terpenes

1995
The inhibition of protein prenyltransferases by oxygenated metabolites of limonene and perillyl alcohol.
    Cancer letters, 1995, May-08, Volume: 91, Issue:2

    Topics: Animals; Brain; Cattle; Cyclohexenes; Enzyme Inhibitors; Fungal Proteins; GTP-Binding Proteins; In Vitro Techniques; Kinetics; Limonene; Monoterpenes; Oxidation-Reduction; Protein Prenylation; Saccharomyces cerevisiae; Structure-Activity Relationship; Terpenes; Transferases

1995
Mammary carcinoma regression induced by perillyl alcohol, a hydroxylated analog of limonene.
    Cancer chemotherapy and pharmacology, 1994, Volume: 34, Issue:6

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Body Weight; Cyclohexenes; Dose-Response Relationship, Drug; Eating; Female; Limonene; Mammary Neoplasms, Experimental; Monoterpenes; Rats; Rats, Wistar; Terpenes; Time Factors

1994
Isoprenylation of proteins in the protozoan Giardia lamblia.
    Molecular and biochemical parasitology, 1995, Volume: 72, Issue:1-2

    Topics: Acetylcysteine; Animals; Cholesterol; Cyclohexenes; Dolichols; Giardia lamblia; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Limonene; Lipid Metabolism; Lovastatin; Mevalonic Acid; Monoterpenes; Protein Prenylation; Proto-Oncogene Proteins p21(ras); Protozoan Proteins; Terpenes; Ubiquinone

1995
Chemoprevention of breast cancer.
    JAMA, 1996, May-01, Volume: 275, Issue:17

    Topics: Anticarcinogenic Agents; Antineoplastic Agents, Hormonal; Biomarkers, Tumor; Breast Neoplasms; Carcinoma in Situ; Carcinoma, Ductal, Breast; Clinical Trials as Topic; Combined Modality Therapy; Cyclohexenes; Dehydroepiandrosterone; Estrogen Antagonists; Female; Genistein; Humans; Isoflavones; Limonene; Middle Aged; Monoterpenes; Neoplasm Recurrence, Local; Neoplasms, Hormone-Dependent; Retinoids; Tamoxifen; Terpenes

1996
Inhibition of tumor cell growth by monoterpenes in vitro: evidence of a Ras-independent mechanism of action.
    Anti-cancer drugs, 1996, Volume: 7, Issue:4

    Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Benzodiazepines; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cell Transformation, Neoplastic; Collagenases; Cyclohexenes; Enzyme Inhibitors; Farnesyltranstransferase; Fibroblasts; Genes, ras; Limonene; Monoterpenes; Oligopeptides; Pancreatic Neoplasms; Promoter Regions, Genetic; ras Proteins; Rats; Terpenes; Transferases

1996
Effects of monoterpenes and mevinolin on murine colon tumor CT-26 in vitro and its hepatic "metastases" in vivo.
    Advances in experimental medicine and biology, 1996, Volume: 401

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Colonic Neoplasms; Cyclohexenes; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Limonene; Liver Neoplasms; Lovastatin; Mice; Mice, Inbred BALB C; Monoterpenes; Protein Prenylation; Terpenes; Tumor Cells, Cultured

1996
Modulation of RAS expression in human malignant cells by dietary supplements.
    Nutrition (Burbank, Los Angeles County, Calif.), 1997, Volume: 13, Issue:10

    Topics: Antineoplastic Agents; Cyclohexenes; Dietary Supplements; Fatty Acids, Omega-3; Garlic; Gene Expression Regulation, Neoplastic; Genes, ras; Humans; Limonene; Monoterpenes; Neoplasms; Plants, Medicinal; Tea; Terpenes

1997
Monoterpenes inhibit cell growth, cell cycle progression, and cyclin D1 gene expression in human breast cancer cell lines.
    Nutrition and cancer, 1998, Volume: 32, Issue:1

    Topics: Antineoplastic Agents; Breast Neoplasms; Cell Cycle; Cell Division; Cyclin D1; Cyclohexenes; Disease Progression; Female; Gene Expression Regulation, Neoplastic; Humans; Limonene; Monoterpenes; Terpenes; Tumor Cells, Cultured

1998
Sex differences in the metabolism of (+)- and (-)-limonene enantiomers to carveol and perillyl alcohol derivatives by cytochrome p450 enzymes in rat liver microsomes.
    Chemical research in toxicology, 2002, Volume: 15, Issue:1

    Topics: Animals; Cyclohexane Monoterpenes; Cyclohexenes; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Gas Chromatography-Mass Spectrometry; In Vitro Techniques; Isoenzymes; Limonene; Male; Microsomes, Liver; Monoterpenes; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Sex Factors; Stereoisomerism; Terpenes

2002
Metabolism of (+)- and (-)-limonenes to respective carveols and perillyl alcohols by CYP2C9 and CYP2C19 in human liver microsomes.
    Drug metabolism and disposition: the biological fate of chemicals, 2002, Volume: 30, Issue:5

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cells, Cultured; Cyclohexane Monoterpenes; Cyclohexenes; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System; Gas Chromatography-Mass Spectrometry; Humans; In Vitro Techniques; Insecta; Limonene; Microsomes, Liver; Mixed Function Oxygenases; Monoterpenes; Oxidation-Reduction; Protective Agents; Rats; Recombinant Proteins; Stereoisomerism; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Terpenes

2002
Effect of D-limonene on immune response in BALB/c mice with lymphoma.
    International immunopharmacology, 2005, Volume: 5, Issue:5

    Topics: Animals; Chemotaxis; Cyclohexenes; Dinitrofluorobenzene; Escherichia coli; Female; Hypersensitivity, Delayed; Immunization; Immunologic Factors; In Vitro Techniques; Leukemia L5178; Limonene; Lymphocyte Activation; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; Monoterpenes; Nitric Oxide; T-Lymphocyte Subsets; Terpenes

2005
Biocatalytic production of perillyl alcohol from limonene by using a novel Mycobacterium sp. cytochrome P450 alkane hydroxylase expressed in Pseudomonas putida.
    Applied and environmental microbiology, 2005, Volume: 71, Issue:4

    Topics: Amino Acid Sequence; Cyclohexenes; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Industrial Microbiology; Limonene; Molecular Sequence Data; Monoterpenes; Mycobacterium; Pseudomonas putida; Sequence Analysis, DNA; Terpenes

2005
Anti-inflammatory senescence actives 5203-L molecule to promote healthy aging and prolongation of lifespan.
    Rejuvenation research, 2008, Volume: 11, Issue:2

    Topics: Affect; Animals; Cells, Cultured; Cyclohexenes; Female; Health; Humans; Intercellular Adhesion Molecule-1; Limonene; Longevity; Monoterpenes; Motor Activity; Pain; Rats; Rats, Wistar; Stress, Physiological; Terpenes; Toxicity Tests; Tumor Necrosis Factor-alpha

2008
Components of lemon essential oil attenuate dementia induced by scopolamine.
    Nutritional neuroscience, 2009, Volume: 12, Issue:2

    Topics: Animals; Avoidance Learning; Brain Chemistry; Corpus Striatum; Cyclohexenes; Dementia; Dopamine; Habituation, Psychophysiologic; Hippocampus; Limonene; Male; Memory; Monoterpenes; Motor Activity; Plant Oils; Rats; Rats, Wistar; Scopolamine; Terpenes

2009
Tricistronic overexpression of cytochrome P450cam, putidaredoxin, and putidaredoxin reductase provides a useful cell-based catalytic system.
    Biotechnology letters, 2009, Volume: 31, Issue:9

    Topics: Biotransformation; Camphor; Camphor 5-Monooxygenase; Cyclohexenes; Escherichia coli; Ferredoxins; Gene Dosage; Gene Expression; Limonene; Monoterpenes; NADH, NADPH Oxidoreductases; Pseudomonas putida; Recombinant Proteins; Terpenes

2009
Cell physiology rather than enzyme kinetics can determine the efficiency of cytochrome P450-catalyzed C-H-oxyfunctionalization.
    Journal of industrial microbiology & biotechnology, 2011, Volume: 38, Issue:9

    Topics: Biocatalysis; Biotransformation; Cyclohexenes; Cytochrome P-450 Enzyme System; Cytochromes; Hydroxylation; Kinetics; Limonene; Monoterpenes; Pseudomonas putida; Recombinant Proteins; Terpenes

2011
An efficient route to selective bio-oxidation catalysts: an iterative approach comprising modeling, diversification, and screening, based on CYP102A1.
    Chembiochem : a European journal of chemical biology, 2011, Jun-14, Volume: 12, Issue:9

    Topics: Bacterial Proteins; Biocatalysis; Computer Simulation; Cyclohexenes; Cytochrome P-450 Enzyme System; Genetic Engineering; Hydroxylation; Limonene; Models, Molecular; Molecular Structure; Monoterpenes; Mutation; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Terpenes

2011
Influence of the active compounds of Perilla frutescens leaves on lipid membranes.
    Journal of natural products, 2012, Feb-24, Volume: 75, Issue:2

    Topics: Cell Membrane; Cyclohexenes; Dimyristoylphosphatidylcholine; Limonene; Membrane Lipids; Models, Molecular; Molecular Structure; Monoterpenes; Perilla frutescens; Plant Leaves; Plants, Medicinal; Terpenes

2012
Whole-cell-based CYP153A6-catalyzed (S)-limonene hydroxylation efficiency depends on host background and profits from monoterpene uptake via AlkL.
    Biotechnology and bioengineering, 2013, Volume: 110, Issue:5

    Topics: Bacterial Outer Membrane Proteins; Bioreactors; Cyclohexenes; Cytochrome P-450 Enzyme System; Escherichia coli; Hydroxylation; Isoenzymes; Limonene; Monoterpenes; Pseudomonas putida; Terpenes

2013
Metabolic engineering of Escherichia coli for limonene and perillyl alcohol production.
    Metabolic engineering, 2013, Volume: 19

    Topics: Antineoplastic Agents; Cyclohexenes; Cytochrome P-450 Enzyme System; Escherichia coli; Escherichia coli Proteins; Hydroxylation; Limonene; Metabolic Engineering; Mevalonic Acid; Monoterpenes; Terpenes

2013
Anti-stress effects of d-limonene and its metabolite perillyl alcohol.
    Rejuvenation research, 2014, Volume: 17, Issue:2

    Topics: Animals; Behavior, Animal; Cyclohexenes; Feeding Behavior; Female; Limonene; Monoterpenes; Rats, Wistar; Stress, Physiological; Terpenes; Time Factors

2014
Skin repair properties of d-Limonene and perillyl alcohol in murine models.
    Anti-inflammatory & anti-allergy agents in medicinal chemistry, 2014, Volume: 13, Issue:1

    Topics: Administration, Cutaneous; Angiogenesis Inhibitors; Animals; Cells, Cultured; Citrus sinensis; Cyclohexenes; Cytokines; Dermatitis, Irritant; Disease Models, Animal; Endothelium; Female; Fruit; Gene Expression Regulation; Humans; Inflammation Mediators; Limonene; Mice; Mice, Hairless; Microtubules; Monoterpenes; P-Selectin; Phorbol Esters; Phytotherapy; Skin; Terpenes; Wound Healing

2014
The epoxidation of limonene over the TS-1 and Ti-SBA-15 catalysts.
    Molecules (Basel, Switzerland), 2014, Nov-28, Volume: 19, Issue:12

    Topics: Catalysis; Cyclohexane Monoterpenes; Cyclohexenes; Epoxy Compounds; Limonene; Monoterpenes; Oxidation-Reduction; Silicates; Silicon Dioxide; Temperature; Terpenes; Time Factors; Titanium

2014
R-Limonene metabolism in humans and metabolite kinetics after oral administration.
    Archives of toxicology, 2017, Volume: 91, Issue:3

    Topics: Administration, Oral; Adult; Cyclohexane Monoterpenes; Cyclohexenes; Female; Gas Chromatography-Mass Spectrometry; Half-Life; Humans; Limonene; Male; Monoterpenes; Terpenes

2017
Molecular cloning and characterization of a Perilla frutescens cytochrome P450 enzyme that catalyzes the later steps of perillaldehyde biosynthesis.
    Phytochemistry, 2017, Volume: 134

    Topics: Cloning, Molecular; Cyclohexenes; Cytochrome P-450 Enzyme System; Diphosphates; Diterpenes; Gene Library; Limonene; Monoterpenes; Oils, Volatile; Perilla frutescens; Recombinant Proteins; Terpenes

2017
Hydroxyl Group and Vasorelaxant Effects of Perillyl Alcohol, Carveol, Limonene on Aorta Smooth Muscle of Rats.
    Molecules (Basel, Switzerland), 2018, Jun-13, Volume: 23, Issue:6

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Aorta, Thoracic; Cyclohexane Monoterpenes; Cyclohexenes; Isometric Contraction; Limonene; Molecular Structure; Monoterpenes; Muscle, Smooth, Vascular; Phenylephrine; Phorbol 12,13-Dibutyrate; Rats; Structure-Activity Relationship; Terpenes; Vasodilator Agents

2018
Limonene, a food additive, and its active metabolite perillyl alcohol improve regeneration and attenuate neuropathic pain after peripheral nerve injury: Evidence for IL-1β, TNF-α, GAP, NGF and ERK involvement.
    International immunopharmacology, 2020, Volume: 86

    Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Food Additives; GTPase-Activating Proteins; Humans; Interleukin-1beta; Limonene; Male; Mice; Monoterpenes; Motor Neurons; Nerve Growth Factor; Neuralgia; Peripheral Nerve Injuries; Regeneration; Tumor Necrosis Factor-alpha

2020
Effectiveness of recombinant Escherichia coli on the production of (R)-(+)-perillyl alcohol.
    BMC biotechnology, 2021, 01-08, Volume: 21, Issue:1

    Topics: Bioreactors; Escherichia coli; Limonene; Metabolic Engineering; Mevalonic Acid; Monoterpenes

2021