perifosine has been researched along with miltefosine in 24 studies
| Studies (perifosine) | Trials (perifosine) | Recent Studies (post-2010) (perifosine) | Studies (miltefosine) | Trials (miltefosine) | Recent Studies (post-2010) (miltefosine) |
|---|---|---|---|---|---|
| 245 | 31 | 140 | 1,330 | 83 | 769 |
| Protein | Taxonomy | perifosine (IC50) | miltefosine (IC50) |
|---|---|---|---|
| RAC-alpha serine/threonine-protein kinase | Homo sapiens (human) | 9.6 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (16.67) | 18.2507 |
| 2000's | 9 (37.50) | 29.6817 |
| 2010's | 10 (41.67) | 24.3611 |
| 2020's | 1 (4.17) | 2.80 |
| Authors | Studies |
|---|---|
| Croft, SL; Kayser, O; Lemke, A; Seifert, K | 1 |
| Castanys, S; Castanys-Muñoz, E; Gamarro, F; Pérez-Victoria, JM | 1 |
| Bajorath, J; Batista, J; Braxmeier, T; Friedrichson, T; Jennings, G; Schlechtingen, G | 1 |
| Alam, MM; Hong, J; Joh, EH; Kim, B; Kim, DH; Kim, Y; Lee, YS; Oh, YI | 1 |
| Alam, MM; Joh, EH; Kim, B; Kim, DH; Lee, YS; Park, H | 1 |
| Engel, J; Hilgard, P; Klenner, T; Kutscher, B; Nössner, G; Stekar, J | 1 |
| Arndt, D; Fichtner, I; Stahn, R; Zeisig, R | 1 |
| Bartelink, H; Ruiter, GA; van Blitterswijk, WJ; Verheij, M; Zerp, SF | 2 |
| Berger, MR; Eibl, H; Konstantinov, SM | 1 |
| Ruiter, GA; van Blitterswijk, WJ; Verheij, M; Zerp, SF | 1 |
| Boeck, G; Grunicke, H; Hofmann, J; Knebel, NG; Rybczynska, M; Spitaler, M | 1 |
| Agresta, M; D'Arrigo, P; Fasoli, E; Losi, D; Pedrocchi-Fantoni, G; Riva, S; Servi, S; Tessaro, D | 1 |
| Mravljak, J; Pecar, S; Zeisig, R | 1 |
| Alder-Baerens, N; Castanys, S; Castanys-Muñoz, E; Gamarro, F; Pomorski, T | 1 |
| Cabrera-Serra, MG; Piñero, JE; Valladares, B | 1 |
| Bhatt, AP; Bhende, PM; Damania, B; Dittmer, DP; Roy, D; Sin, SH | 1 |
| van Blitterswijk, WJ; Verheij, M | 1 |
| Gradziel, CS; Redfield, AG; Roberts, MF; Stec, B; Wang, Y | 1 |
| Dakir, EL; Dakir, el H; López-Abán, J; Mollinedo, F; Muro, A; Varela-M, RE; Yepes, E | 1 |
| Cabello, J; Mohler, WA; Mollinedo, F; Reis-Sobreiro, M; Rodríguez-Matellán, AG; Sáenz-Narciso, B; Sánchez-Blanco, A | 1 |
| Gajate, C; Legarda-Ceballos, AL; López-Abán, J; Mollinedo, F; Muro, A; Rojas-Caraballo, J; Ruano, AL; Yepes, E | 1 |
| López-Arencibia, A; Lorenzo-Morales, J; Maciver, SK; Martín-Navarro, C; Piñero, JE; Reyes-Batlle, M; Sifaoui, I; Wagner, C | 1 |
| Gaillard, B; Lebeau, L; Pons, F; Remy, JS | 1 |
2 review(s) available for perifosine and miltefosine
| Article | Year |
|---|---|
Alkyl-lysophospholipids as anticancer agents and enhancers of radiation-induced apoptosis.
Topics: Antineoplastic Agents; Phosphodiesterase Inhibitors; Phospholipid Ethers; Phospholipids; Phosphorylcholine; Signal Transduction | 2001 |
Anticancer mechanisms and clinical application of alkylphospholipids.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Membrane; Endocytosis; Humans; Neoplasms; Organophosphates; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Phospholipid Ethers; Phosphorylcholine; Proto-Oncogene Proteins c-akt; Quaternary Ammonium Compounds; Signal Transduction | 2013 |
22 other study(ies) available for perifosine and miltefosine
| Article | Year |
|---|---|
Antileishmanial structure-activity relationships of synthetic phospholipids: in vitro and in vivo activities of selected derivatives.
Topics: Animals; Antiprotozoal Agents; Cell Line, Tumor; Cell Survival; Cricetinae; Humans; Inhibitory Concentration 50; Leishmania donovani; Lethal Dose 50; Molecular Structure; Phospholipids; Structure-Activity Relationship | 2007 |
Characterization of an ABCG-like transporter from the protozoan parasite Leishmania with a role in drug resistance and transbilayer lipid movement.
Topics: Aminoquinolines; Animals; Antiprotozoal Agents; ATP-Binding Cassette Transporters; Base Sequence; Biological Transport, Active; Chloroquine; DNA, Protozoan; Drug Resistance; Fluorescent Dyes; Genes, Protozoan; Humans; Leishmania infantum; Leishmaniasis, Visceral; Lipid Bilayers; Phosphorylcholine; Protozoan Proteins; Recombinant Proteins; Transformation, Genetic | 2008 |
Computational screening for membrane-directed inhibitors of mast cell activation.
Topics: Animals; Cell Degranulation; Cell Line, Tumor; Cell Membrane; Computational Biology; Computer Simulation; Drug Evaluation, Preclinical; Mast Cells; Models, Molecular; Molecular Conformation; Rats | 2010 |
Synthesis and biological evaluation of cyclopentane-linked alkyl phosphocholines as potential anticancer agents that act by inhibiting Akt phosphorylation.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cyclopentanes; Humans; Inhibitory Concentration 50; Phosphorylation; Phosphorylcholine; Proto-Oncogene Proteins c-akt; Stereoisomerism | 2012 |
Synthesis, characterization and Akt phosphorylation inhibitory activity of cyclopentanecarboxylate-substituted alkylphosphocholines.
Topics: Antineoplastic Agents; Carboxylic Acids; Cell Line, Tumor; Cell Proliferation; Cyclopentanes; Humans; Neoplasms; Phospholipid Ethers; Phosphorylation; Phosphorylcholine; Proto-Oncogene Proteins c-akt | 2013 |
D-21266, a new heterocyclic alkylphospholipid with antitumour activity.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Body Weight; Dose-Response Relationship, Drug; Female; Mammary Neoplasms, Experimental; Phosphorylcholine; Rats; Rats, Sprague-Dawley; Tumor Cells, Cultured | 1997 |
Physical properties and pharmacological activity in vitro and in vivo of optimised liposomes prepared from a new cancerostatic alkylphospholipid.
Topics: Animals; Breast Neoplasms; Cell Division; Female; Humans; Liposomes; Metallothionein 3; Mice; Mice, Nude; Phosphorylcholine; Tumor Cells, Cultured | 1998 |
Alkyl-lysophospholipids activate the SAPK/JNK pathway and enhance radiation-induced apoptosis.
Topics: Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Endothelium, Vascular; Gamma Rays; Humans; JNK Mitogen-Activated Protein Kinases; Jurkat Cells; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 12; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phospholipid Ethers; Phosphorylcholine; Protein Kinases; Signal Transduction; U937 Cells | 1999 |
BCR-ABL influences the antileukaemic efficacy of alkylphosphocholines.
Topics: Apoptosis; Cell Adhesion; Cell Survival; Dose-Response Relationship, Drug; Fusion Proteins, bcr-abl; HL-60 Cells; Humans; Molecular Structure; Phosphorylcholine; Structure-Activity Relationship; Tumor Cells, Cultured | 1999 |
Effects of miltefosine on various biochemical parameters in a panel of tumor cell lines with different sensitivities.
Topics: Antineoplastic Agents; Apoptosis; Biological Transport; Cell Cycle; Cholesterol; Drug Screening Assays, Antitumor; Endocytosis; Humans; Phospholipids; Phosphorylcholine; Tumor Cells, Cultured | 2001 |
Anti-cancer alkyl-lysophospholipids inhibit the phosphatidylinositol 3-kinase-Akt/PKB survival pathway.
Topics: Antineoplastic Agents; Apoptosis; Dose-Response Relationship, Drug; Growth Inhibitors; HeLa Cells; Humans; Mitogen-Activated Protein Kinase 12; Mitogen-Activated Protein Kinases; Neoplasms, Glandular and Epithelial; Phosphatidylinositol 3-Kinases; Phospholipid Ethers; Phosphorylation; Phosphorylcholine; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction | 2003 |
Synthesis and antiproliferative activity of alkylphosphocholines.
Topics: Animals; Antineoplastic Agents; Cell Division; Cell Line; HeLa Cells; Hemolysis; Humans; Inhibitory Concentration 50; Jurkat Cells; K562 Cells; Macrophages; Mice; Molecular Structure; Phospholipase D; Phosphorylcholine; Structure-Activity Relationship; Tetrazolium Salts; Thymidine | 2003 |
Synthesis and biological evaluation of spin-labeled alkylphospholipid analogs.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cyclic N-Oxides; Drug Screening Assays, Antitumor; Hemolysis; Humans; Liposomes; Micelles; Organophosphates; Phospholipids; Phosphorylcholine; Solutions; Spin Labels; Structure-Activity Relationship; Surface-Active Agents | 2005 |
A novel ATP-binding cassette transporter from Leishmania is involved in transport of phosphatidylcholine analogues and resistance to alkyl-phospholipids.
Topics: Animals; Antiprotozoal Agents; ATP-Binding Cassette Transporters; Biological Transport; Cell Membrane; Dimerization; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Green Fluorescent Proteins; Leishmania infantum; Phosphatidylcholines; Phospholipid Ethers; Phosphorylcholine; Saccharomyces cerevisiae; Transformation, Genetic | 2007 |
In vivo activity of perifosine against Leishmania amazonensis.
Topics: Administration, Oral; Animals; Antiprotozoal Agents; Female; Leishmania mexicana; Leishmaniasis, Cutaneous; Mice; Mice, Inbred BALB C; Phospholipid Ethers; Phosphorylcholine; Survival Analysis | 2008 |
Dual inhibition of PI3K and mTOR inhibits autocrine and paracrine proliferative loops in PI3K/Akt/mTOR-addicted lymphomas.
Topics: Animals; Antineoplastic Agents; Apoptosis; Autocrine Communication; Cell Line, Tumor; Cell Proliferation; Cytokines; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; Lymphoma, Primary Effusion; Mice; Mice, Inbred NOD; Mice, SCID; Paracrine Communication; Phosphoinositide-3 Kinase Inhibitors; Phosphorylcholine; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Quinolines; Rosiglitazone; Thiazolidinediones; TOR Serine-Threonine Kinases; Xenograft Model Antitumor Assays | 2010 |
Cytotoxic amphiphiles and phosphoinositides bind to two discrete sites on the Akt1 PH domain.
Topics: Antineoplastic Agents; Binding Sites; Humans; Micelles; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Phosphatidylinositols; Phosphorylcholine; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Spin Labels | 2014 |
In vitro and in vivo anti-schistosomal activity of the alkylphospholipid analog edelfosine.
Topics: Animals; Antineoplastic Agents; Antiparasitic Agents; Apoptosis; Female; Mice; Phospholipid Ethers; Phosphorylcholine; Schistosoma mansoni; Schistosomiasis mansoni | 2014 |
Caenorhabditis elegans as a platform to study the mechanism of action of synthetic antitumor lipids.
Topics: Animals; Antineoplastic Agents; Apoptosis; Caenorhabditis elegans; Cell Line, Tumor; Cholesterol; Drug Resistance; Embryo, Nonmammalian; Embryonic Development; Humans; Insulin-Like Growth Factor I; Larva; Membrane Microdomains; Phospholipid Ethers; Phosphorylcholine | 2014 |
The alkylphospholipid edelfosine shows activity against Strongyloides venezuelensis and induces apoptosis-like cell death.
Topics: Animals; Antineoplastic Agents; Apoptosis; Dose-Response Relationship, Drug; Female; Larva; Mice; Phospholipid Ethers; Phosphorylcholine; Strongyloides; Strongyloidiasis | 2016 |
Perifosine Mechanisms of Action in Leishmania Species.
Topics: Adenosine Triphosphate; Antiprotozoal Agents; Apoptosis; Gene Expression; Inhibitory Concentration 50; Leishmania donovani; Leishmania mexicana; Membrane Potential, Mitochondrial; Mitochondria; Phosphatidylserines; Phosphorylation; Phosphorylcholine; Proto-Oncogene Proteins c-akt; Protozoan Proteins | 2017 |
Synthesis and Evaluation of Antitumor Alkylphospholipid Prodrugs.
Topics: Administration, Intravenous; Antineoplastic Agents; Cell Line, Tumor; Drug Screening Assays, Antitumor; Drug Stability; Hemolysis; Humans; Maximum Tolerated Dose; Neoplasms; Organophosphates; Phosphorylcholine; Prodrugs; Quaternary Ammonium Compounds | 2020 |