perifosine has been researched along with etoposide in 4 studies
| Studies (perifosine) | Trials (perifosine) | Recent Studies (post-2010) (perifosine) | Studies (etoposide) | Trials (etoposide) | Recent Studies (post-2010) (etoposide) |
|---|---|---|---|---|---|
| 245 | 31 | 140 | 18,306 | 3,693 | 4,900 |
| Protein | Taxonomy | perifosine (IC50) | etoposide (IC50) |
|---|---|---|---|
| nuclear receptor coactivator 1 isoform 1 [Homo sapiens] | Homo sapiens (human) | 1.153 | |
| nuclear receptor coactivator 3 isoform a | Homo sapiens (human) | 1.4284 | |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Oryctolagus cuniculus (rabbit) | 3.187 | |
| Caspase-3 | Homo sapiens (human) | 1 | |
| DNA topoisomerase 2-beta | Homo sapiens (human) | 0.4299 | |
| Solute carrier organic anion transporter family member 1B3 | Homo sapiens (human) | 4.18 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cappellini, A; Mantovani, I; Martelli, AM; Nyåkern, M | 1 |
| Broaddus, WC; Fillmore, HL; Kadian, R; Kumar, A; Tye, GW; Van Meter, TE | 1 |
| Li, Z; Nakamura, K; Oh, DY; Thiele, CJ | 1 |
| Ding, HM; Gu, ZP; Li, D; Wang, ZY; Wei, JJ; Yan, SC; Yang, YJ; Yao, C | 1 |
4 other study(ies) available for perifosine and etoposide
| Article | Year |
|---|---|
Synergistic induction of apoptosis in human leukemia T cells by the Akt inhibitor perifosine and etoposide through activation of intrinsic and Fas-mediated extrinsic cell death pathways.
Topics: Apoptosis; Drug Combinations; Drug Synergism; Enzyme Activation; Etoposide; fas Receptor; Humans; Jurkat Cells; Phosphorylcholine; Proto-Oncogene Proteins c-akt; Signal Transduction | 2006 |
The alkylphospholipid perifosine induces apoptosis and p21-mediated cell cycle arrest in medulloblastoma.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Cycle; Cell Line, Tumor; Cell Survival; Cerebellar Neoplasms; Child; Cyclin-Dependent Kinase Inhibitor p21; Etoposide; Humans; Isoenzymes; Medulloblastoma; Phosphorylcholine; Proto-Oncogene Proteins c-akt; RNA, Small Interfering; Transfection | 2009 |
Perifosine-induced inhibition of Akt attenuates brain-derived neurotrophic factor/TrkB-induced chemoresistance in neuroblastoma in vivo.
Topics: Brain Neoplasms; Brain-Derived Neurotrophic Factor; Cell Line, Tumor; Drug Resistance, Neoplasm; Etoposide; Humans; Neuroblastoma; Phosphorylation; Phosphorylcholine; Proto-Oncogene Proteins c-akt; Receptor, trkB; Tetracycline | 2011 |
Perifosine induces cell apoptosis in human osteosarcoma cells: new implication for osteosarcoma therapy?
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Doxorubicin; Drug Synergism; Enzyme-Linked Immunosorbent Assay; Etoposide; Humans; JNK Mitogen-Activated Protein Kinases; Mechanistic Target of Rapamycin Complex 1; Multiprotein Complexes; Osteosarcoma; Phosphorylcholine; Proto-Oncogene Proteins c-akt; Signal Transduction; TOR Serine-Threonine Kinases; Tumor Suppressor Protein p53 | 2013 |