perifosine has been researched along with edelfosine in 20 studies
| Studies (perifosine) | Trials (perifosine) | Recent Studies (post-2010) (perifosine) | Studies (edelfosine) | Trials (edelfosine) | Recent Studies (post-2010) (edelfosine) |
|---|---|---|---|---|---|
| 245 | 31 | 140 | 454 | 7 | 85 |
| 245 | 31 | 140 | 20 | 0 | 11 |
| Protein | Taxonomy | perifosine (IC50) | edelfosine (IC50) |
|---|---|---|---|
| Platelet-activating factor receptor | Cavia porcellus (domestic guinea pig) | 1.8 | |
| RAC-alpha serine/threonine-protein kinase | Homo sapiens (human) | 3.5 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (10.00) | 18.2507 |
| 2000's | 9 (45.00) | 29.6817 |
| 2010's | 9 (45.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Castanys, S; Castanys-Muñoz, E; Gamarro, F; Pérez-Victoria, JM | 1 |
| Alam, MM; Joh, EH; Kim, B; Kim, DH; Lee, YS; Park, H | 1 |
| Bartelink, H; Ruiter, GA; van Blitterswijk, WJ; Verheij, M; Zerp, SF | 2 |
| Grosman, N | 1 |
| Ruiter, GA; van Blitterswijk, WJ; Verheij, M; Zerp, SF | 1 |
| Gajate, C; Mollinedo, F | 1 |
| Alder-Baerens, N; Castanys, S; Castanys-Muñoz, E; Gamarro, F; Pomorski, T | 1 |
| Klarenbeek, JB; Perrissoud, D; Solary, E; van Blitterswijk, WJ; van der Luit, AH; Verheij, M; Vink, SR | 1 |
| Klarenbeek, JB; van Blitterswijk, WJ; van der Luit, AH; Verheij, M; Vink, SR | 1 |
| Bartelink, H; Budde, M; de Jong, D; Koolwijk, P; Peters, E; Ruiter, GA; van Blitterswijk, WJ; van der Luit, AH; Verheij, M; Vink, SR; Zerp, SF | 1 |
| Cabrera-Serra, MG; Piñero, JE; Valladares, B | 1 |
| Carrasco, MP; Jiménez-López, JM; Marco, C; Ríos-Marco, P; Segovia, JL | 1 |
| Chae, S; Kim, B; Kim, DH; Kim, Y; Lucas, A; Rivera-Pabon, O | 1 |
| van Blitterswijk, WJ; Verheij, M | 1 |
| Burgeiro, A; Carvalho, FS; Mollinedo, F; Oliveira, PJ; Pereira, CV; Pereira, GC | 1 |
| Dakir, EL; Dakir, el H; López-Abán, J; Mollinedo, F; Muro, A; Varela-M, RE; Yepes, E | 1 |
| Cabello, J; Mohler, WA; Mollinedo, F; Reis-Sobreiro, M; Rodríguez-Matellán, AG; Sáenz-Narciso, B; Sánchez-Blanco, A | 1 |
| Gajate, C; Legarda-Ceballos, AL; López-Abán, J; Mollinedo, F; Muro, A; Rojas-Caraballo, J; Ruano, AL; Yepes, E | 1 |
| Bajorath, J; Batista, J; Braxmeier, T; Friedrichson, T; Jennings, G; Schlechtingen, G | 1 |
2 review(s) available for perifosine and edelfosine
| Article | Year |
|---|---|
Alkyl-lysophospholipids as anticancer agents and enhancers of radiation-induced apoptosis.
Topics: Antineoplastic Agents; Phosphodiesterase Inhibitors; Phospholipid Ethers; Phospholipids; Phosphorylcholine; Signal Transduction | 2001 |
Anticancer mechanisms and clinical application of alkylphospholipids.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Membrane; Endocytosis; Humans; Neoplasms; Organophosphates; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Phospholipid Ethers; Phosphorylcholine; Proto-Oncogene Proteins c-akt; Quaternary Ammonium Compounds; Signal Transduction | 2013 |
18 other study(ies) available for perifosine and edelfosine
| Article | Year |
|---|---|
Characterization of an ABCG-like transporter from the protozoan parasite Leishmania with a role in drug resistance and transbilayer lipid movement.
Topics: Aminoquinolines; Animals; Antiprotozoal Agents; ATP-Binding Cassette Transporters; Base Sequence; Biological Transport, Active; Chloroquine; DNA, Protozoan; Drug Resistance; Fluorescent Dyes; Genes, Protozoan; Humans; Leishmania infantum; Leishmaniasis, Visceral; Lipid Bilayers; Phosphorylcholine; Protozoan Proteins; Recombinant Proteins; Transformation, Genetic | 2008 |
Synthesis, characterization and Akt phosphorylation inhibitory activity of cyclopentanecarboxylate-substituted alkylphosphocholines.
Topics: Antineoplastic Agents; Carboxylic Acids; Cell Line, Tumor; Cell Proliferation; Cyclopentanes; Humans; Neoplasms; Phospholipid Ethers; Phosphorylation; Phosphorylcholine; Proto-Oncogene Proteins c-akt | 2013 |
Alkyl-lysophospholipids activate the SAPK/JNK pathway and enhance radiation-induced apoptosis.
Topics: Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Endothelium, Vascular; Gamma Rays; Humans; JNK Mitogen-Activated Protein Kinases; Jurkat Cells; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 12; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phospholipid Ethers; Phosphorylcholine; Protein Kinases; Signal Transduction; U937 Cells | 1999 |
Effect of the anti-neoplastic agents edelfosine (ET-18-OCH3), ilmofosine (BM 41.440) and the hexadecylphosphocholine analogues D-20133 and D-21266 on histamine release from isolated rat mast cells.
Topics: Animals; Antineoplastic Agents; Calcimycin; Histamine Release; Ionophores; Male; Mast Cells; Phorbol Esters; Phospholipid Ethers; Phosphorylcholine; Piperidines; Rats; Rats, Wistar | 1999 |
Anti-cancer alkyl-lysophospholipids inhibit the phosphatidylinositol 3-kinase-Akt/PKB survival pathway.
Topics: Antineoplastic Agents; Apoptosis; Dose-Response Relationship, Drug; Growth Inhibitors; HeLa Cells; Humans; Mitogen-Activated Protein Kinase 12; Mitogen-Activated Protein Kinases; Neoplasms, Glandular and Epithelial; Phosphatidylinositol 3-Kinases; Phospholipid Ethers; Phosphorylation; Phosphorylcholine; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction | 2003 |
Edelfosine and perifosine induce selective apoptosis in multiple myeloma by recruitment of death receptors and downstream signaling molecules into lipid rafts.
Topics: Apoptosis; Caspase 8; Cell Line, Tumor; Cell Proliferation; fas Receptor; Fas-Associated Death Domain Protein; Humans; Membrane Microdomains; Multiple Myeloma; Phospholipid Ethers; Phosphorylcholine; Signal Transduction; Structure-Activity Relationship | 2007 |
A novel ATP-binding cassette transporter from Leishmania is involved in transport of phosphatidylcholine analogues and resistance to alkyl-phospholipids.
Topics: Animals; Antiprotozoal Agents; ATP-Binding Cassette Transporters; Biological Transport; Cell Membrane; Dimerization; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Green Fluorescent Proteins; Leishmania infantum; Phosphatidylcholines; Phospholipid Ethers; Phosphorylcholine; Saccharomyces cerevisiae; Transformation, Genetic | 2007 |
A new class of anticancer alkylphospholipids uses lipid rafts as membrane gateways to induce apoptosis in lymphoma cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Endocytosis; HeLa Cells; Humans; Lymphoma; Membrane Microdomains; Mice; Phosphatidylcholines; Phospholipid Ethers; Phospholipids; Phosphorylcholine; Sphingomyelins; Time Factors | 2007 |
Lipid rafts and metabolic energy differentially determine uptake of anti-cancer alkylphospholipids in lymphoma versus carcinoma cells.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Squamous Cell; Cell Line, Tumor; Drug Resistance, Neoplasm; Humans; KB Cells; Lymphoma; Membrane Microdomains; Mice; Phospholipid Ethers; Phospholipids; Phosphorylcholine | 2007 |
Alkylphospholipids inhibit capillary-like endothelial tube formation in vitro: antiangiogenic properties of a new class of antitumor agents.
Topics: Alkylation; Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Apoptosis; Capillaries; Cattle; Cell Line, Tumor; Cells, Cultured; Dose-Response Relationship, Drug; Endothelial Cells; Endothelium, Vascular; Humans; Indicators and Reagents; Phosphodiesterase Inhibitors; Phospholipid Ethers; Phospholipids; Phosphorylcholine | 2008 |
In vivo activity of perifosine against Leishmania amazonensis.
Topics: Administration, Oral; Animals; Antiprotozoal Agents; Female; Leishmania mexicana; Leishmaniasis, Cutaneous; Mice; Mice, Inbred BALB C; Phospholipid Ethers; Phosphorylcholine; Survival Analysis | 2008 |
Disruption of cellular cholesterol transport and homeostasis as a novel mechanism of action of membrane-targeted alkylphospholipid analogues.
Topics: Antineoplastic Agents; Biological Transport; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Membrane; Cholesterol; Drug Delivery Systems; Endoplasmic Reticulum; Gene Expression Regulation, Neoplastic; Homeostasis; Humans; Liver Neoplasms; Membrane Microdomains; Phospholipid Ethers; Phosphorylcholine; Reverse Transcriptase Polymerase Chain Reaction | 2010 |
Targeting the PI3K/Akt cell survival pathway to induce cell death of HIV-1 infected macrophages with alkylphospholipid compounds.
Topics: Anti-HIV Agents; Cell Death; Cell Line; Cells, Cultured; HIV Infections; HIV-1; Humans; Macrophages; Phosphatidylinositol 3-Kinases; Phospholipid Ethers; Phosphorylcholine; Proto-Oncogene Proteins c-akt; Signal Transduction | 2010 |
Edelfosine and perifosine disrupt hepatic mitochondrial oxidative phosphorylation and induce the permeability transition.
Topics: Animals; Antineoplastic Agents; Hydrogen Peroxide; Male; Membrane Potential, Mitochondrial; Mitochondrial Membranes; Oxidative Phosphorylation; Permeability; Phospholipid Ethers; Phosphorylcholine; Rats, Wistar | 2013 |
In vitro and in vivo anti-schistosomal activity of the alkylphospholipid analog edelfosine.
Topics: Animals; Antineoplastic Agents; Antiparasitic Agents; Apoptosis; Female; Mice; Phospholipid Ethers; Phosphorylcholine; Schistosoma mansoni; Schistosomiasis mansoni | 2014 |
Caenorhabditis elegans as a platform to study the mechanism of action of synthetic antitumor lipids.
Topics: Animals; Antineoplastic Agents; Apoptosis; Caenorhabditis elegans; Cell Line, Tumor; Cholesterol; Drug Resistance; Embryo, Nonmammalian; Embryonic Development; Humans; Insulin-Like Growth Factor I; Larva; Membrane Microdomains; Phospholipid Ethers; Phosphorylcholine | 2014 |
The alkylphospholipid edelfosine shows activity against Strongyloides venezuelensis and induces apoptosis-like cell death.
Topics: Animals; Antineoplastic Agents; Apoptosis; Dose-Response Relationship, Drug; Female; Larva; Mice; Phospholipid Ethers; Phosphorylcholine; Strongyloides; Strongyloidiasis | 2016 |
Computational screening for membrane-directed inhibitors of mast cell activation.
Topics: Animals; Cell Degranulation; Cell Line, Tumor; Cell Membrane; Computational Biology; Computer Simulation; Drug Evaluation, Preclinical; Mast Cells; Models, Molecular; Molecular Conformation; Rats | 2010 |