Compounds > perifosine
Page last updated: 2024-09-04

perifosine and dactolisib

perifosine has been researched along with dactolisib in 6 studies

Compound Research Comparison

Studies
(perifosine)		Trials
(perifosine)		Recent Studies (post-2010)
(perifosine)		Studies
(dactolisib)		Trials
(dactolisib)		Recent Studies (post-2010) (dactolisib)
2453114044414405

Protein Interaction Comparison

ProteinTaxonomyperifosine (IC50)dactolisib (IC50)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformRattus norvegicus (Norway rat)0.0053
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformHomo sapiens (human)0.0692
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alphaHomo sapiens (human)0.034
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit betaHomo sapiens (human)0.044
Bile salt export pumpHomo sapiens (human)7.9
Cytochrome P450 1A2Homo sapiens (human)0.079
Cytochrome P450 2D6Homo sapiens (human)0.079
Phosphatidylinositol 3-kinase regulatory subunit alphaHomo sapiens (human)0.1532
Cytochrome P450 2C19Homo sapiens (human)0.014
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformHomo sapiens (human)0.0267
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoformHomo sapiens (human)0.3474
Serine/threonine-protein kinase mTORHomo sapiens (human)0.0233
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Homo sapiens (human)0.1022
Tyrosine-protein kinase JAK3Homo sapiens (human)1
Serine-protein kinase ATMHomo sapiens (human)0.007
Regulatory-associated protein of mTORHomo sapiens (human)0.044
Phosphatidylinositol 3-kinase catalytic subunit type 3Homo sapiens (human)0.45
Phosphoinositide 3-kinase regulatory subunit 5Homo sapiens (human)0.1205
Target of rapamycin complex subunit LST8Homo sapiens (human)0.044
Histone deacetylase 6Homo sapiens (human)0.002
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoformRattus norvegicus (Norway rat)0.01

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's6 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Davis, MI; Khan, J; Li, SQ; Patel, PR; Shen, M; Sun, H; Thomas, CJ1
Aiche, S; Bassermann, F; Becker, W; Canevari, G; Casale, E; Depaolini, SR; Ehrlich, HC; Felder, ER; Feuchtinger, A; Garz, AK; Gohlke, BO; Götze, K; Greif, PA; Hahne, H; Heinzlmeir, S; Helm, D; Huenges, J; Jeremias, I; Kayser, G; Klaeger, S; Koch, H; Koenig, PA; Kramer, K; Kuster, B; Médard, G; Meng, C; Petzoldt, S; Polzer, H; Preissner, R; Qiao, H; Reinecke, M; Reiter, K; Rueckert, L; Ruland, J; Ruprecht, B; Schlegl, J; Schmidt, T; Schneider, S; Schoof, M; Spiekermann, K; Tõnisson, N; Vick, B; Vooder, T; Walch, A; Wilhelm, M; Wu, Z; Zecha, J; Zolg, DP1
Bhatt, AP; Bhende, PM; Damania, B; Dittmer, DP; Roy, D; Sin, SH1
Civallero, M; Cosenza, M; Marcheselli, L; Pozzi, S; Sacchi, S1
Boratyn, E; Durbas, M; Horwacik, I; Kamycka, E; Rokita, H1
Cartagena-Rivera, AX; Chadwick, RS; Logue, JS1

Other Studies

6 other study(ies) available for perifosine and dactolisib

ArticleYear
Identification of potent Yes1 kinase inhibitors using a library screening approach.
    Bioorganic & medicinal chemistry letters, 2013, Aug-01, Volume: 23, Issue:15

    Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship

2013
The target landscape of clinical kinase drugs.
    Science (New York, N.Y.), 2017, 12-01, Volume: 358, Issue:6367

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cytokines; Drug Discovery; fms-Like Tyrosine Kinase 3; Humans; Leukemia, Myeloid, Acute; Lung Neoplasms; Mice; Molecular Targeted Therapy; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proteomics; Xenograft Model Antitumor Assays

2017
Dual inhibition of PI3K and mTOR inhibits autocrine and paracrine proliferative loops in PI3K/Akt/mTOR-addicted lymphomas.
    Blood, 2010, Jun-03, Volume: 115, Issue:22

    Topics: Animals; Antineoplastic Agents; Apoptosis; Autocrine Communication; Cell Line, Tumor; Cell Proliferation; Cytokines; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; Lymphoma, Primary Effusion; Mice; Mice, Inbred NOD; Mice, SCID; Paracrine Communication; Phosphoinositide-3 Kinase Inhibitors; Phosphorylcholine; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Quinolines; Rosiglitazone; Thiazolidinediones; TOR Serine-Threonine Kinases; Xenograft Model Antitumor Assays

2010
NVP-BEZ235 alone and in combination in mantle cell lymphoma: an effective therapeutic strategy.
    Expert opinion on investigational drugs, 2012, Volume: 21, Issue:11

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Bone Marrow; Cell Line, Tumor; Cell Proliferation; Everolimus; Flow Cytometry; G1 Phase Cell Cycle Checkpoints; Humans; Imidazoles; Indoles; Lymphoma, Mantle-Cell; Phosphorylation; Phosphorylcholine; Protein Kinases; Quinolines; Sirolimus

2012
GD2 ganglioside specific antibody treatment downregulates PI3K/Akt/mTOR signaling network in human neuroblastoma cell lines.
    International journal of oncology, 2015, Volume: 47, Issue:3

    Topics: Antibodies, Monoclonal; Apoptosis; Cell Line, Tumor; Drug Synergism; Gangliosides; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Neuroblastoma; Phosphatidylinositol 3-Kinases; Phosphorylcholine; Proto-Oncogene Proteins c-akt; Quinolines; Quinoxalines; Signal Transduction; Sulfonamides; TOR Serine-Threonine Kinases

2015
c-Src activity is differentially required by cancer cell motility modes.
    Oncogene, 2018, Volume: 37, Issue:16

    Topics: Actins; Amino Acid Substitution; Butadienes; Cell Adhesion; Cell Movement; Dasatinib; Humans; Imidazoles; Mutant Proteins; Neoplasms; Nitriles; Phosphorylcholine; Protein Kinase Inhibitors; Proto-Oncogene Proteins pp60(c-src); Quinolines; Tumor Cells, Cultured

2018