perhexiline and propranolol

perhexiline has been researched along with propranolol in 22 studies

Research

Studies (22)

Timeframe	Studies, this research(%)	All Research%
pre-1990	10 (45.45)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (9.09)	29.6817
2010's	9 (40.91)	24.3611
2020's	1 (4.55)	2.80

Authors

Authors	Studies
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Glen, RC; Lowe, R; Mitchell, JB	1
Ekins, S; Williams, AJ; Xu, JJ	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Atzpodien, EA; Csato, M; Doessegger, L; Fischer, H; Lenz, B; Schmitt, G; Singer, T	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y	1
Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M	1
Cho, YW; Ito, H; Matsukawa, H; Okabe, E; Sakamoto, H	1
Beaughard, M; Cosnier, D; Labrid, C; Piris, P	1
Short, D	1
Horowitz, JD; Mashford, ML	1
Caponnetto, S; Iannetti, M; Masperone, MA; Pastorini, C; Perugini, P	1
Caponnetto, S; Iannetti, M; Masperone, MA; Oriani, G; Pastorini, C; Perugini, P	1
Armstrong, ML; Brand, D; Emmett, AJ; Hodge, JL; Kellaway, GS; Mestitz, P; Reefman, M; Wallace, DC	1
Armstrong, ML	1
Cho, YW; Fujisawa, T; Higashi, H; Ito, H; Okabe, E	1
Hashimoto, K; O'Hara, N; Ono, H	1
Arrivet, E; Bichet, N; Fabre, N; Prenez, A; Roome, NO; Trancard, J; Vericat, JA	1

Reviews

1 review(s) available for perhexiline and propranolol

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Trials

3 trial(s) available for perhexiline and propranolol

Article	Year
[Effects of perhexiline maleate in angina pectoris: preliminary clinical and experimental results of a comparative study]. Bollettino della Societa italiana di cardiologia, 1975, Volume: 20, Issue:11 Topics: Angina Pectoris; Clinical Trials as Topic; Drug Evaluation; Humans; Perhexiline; Piperidines; Placebos; Propranolol	1975
A multicentre trial of perhexiline maleate, beta-blocker and placebo in angina pectoris. The Medical journal of Australia, 1974, Sep-14, Volume: 2, Issue:11 Topics: Adrenergic beta-Antagonists; Adult; Aged; Alanine Transaminase; Angina Pectoris; Aspartate Aminotransferases; Clinical Trials as Topic; Female; Humans; Male; Middle Aged; Nitroglycerin; Perhexiline; Placebos; Practolol; Propranolol; Vasodilator Agents	1974
Proceedings: A comparative study of perhexiline, beta-adrenergic blocking agents and placebos in the management of angina pectoris. Postgraduate medical journal, 1973, Volume: 49 Topics: Angina Pectoris; Clinical Trials as Topic; Humans; Perhexiline; Piperidines; Placebos; Practolol; Propranolol; Vasodilator Agents	1973

Other Studies

18 other study(ies) available for perhexiline and propranolol

Article	Year
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
Predicting phospholipidosis using machine learning. Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5 Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
In silico assay for assessing phospholipidosis potential of small druglike molecules: training, validation, and refinement using several data sets. Journal of medicinal chemistry, 2012, Jan-12, Volume: 55, Issue:1 Topics: Animals; Cattle; Cells, Cultured; Computer Simulation; Cornea; Drug-Related Side Effects and Adverse Reactions; Fibroblasts; Lipidoses; Lysosomal Storage Diseases; Models, Molecular; Pharmaceutical Preparations; Phospholipids; Structure-Activity Relationship; Thermodynamics	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships. Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16 Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone	2016
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology. Disease models & mechanisms, 2023, 03-01, Volume: 16, Issue:3 Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries	2023
Cardiovascular effects of isoproterenol and possible antagonistic actions of propranolol and perhexiline. Japanese circulation journal, 1978, Volume: 42, Issue:4 Topics: Adrenergic beta-Antagonists; Animals; Blood Pressure; Cardiac Output; Dogs; Female; Heart Rate; Hemodynamics; In Vitro Techniques; Isoproterenol; Male; Myocardial Contraction; Perhexiline; Piperidines; Propranolol; Rabbits	1978
Activity of bepridil and other anti-anginals on cardiovascular modifications engendered by conditioned anxiety in the dog. Archives internationales de pharmacodynamie et de therapie, 1978, Volume: 235, Issue:1 Topics: Amines; Amiodarone; Angina Pectoris; Animals; Anxiety; Behavior, Animal; Benzylamines; Conditioning, Operant; Dipyridamole; Dogs; Female; Hemodynamics; Humans; Male; Nitroglycerin; Pentaerythritol Tetranitrate; Perhexiline; Propranolol; Pyrrolidines	1978
The management of the patient with angina. American heart journal, 1977, Volume: 94, Issue:2 Topics: Angina Pectoris; Anticoagulants; Clofibrate; Coronary Artery Bypass; Diazepam; Digoxin; Humans; Isosorbide Dinitrate; Nitroglycerin; Oxprenolol; Perhexiline; Prenylamine; Propranolol; Verapamil	1977
Perhexiline maleate in the treatment of severe angina pectoris. The Medical journal of Australia, 1979, Jun-02, Volume: 1, Issue:11 Topics: Alprenolol; Angina Pectoris; Drug Therapy, Combination; Electrocardiography; Female; Humans; Male; Middle Aged; Perhexiline; Piperidines; Propranolol	1979
Effects of sustained isometric handgrip on ventricular systolic time intervals in patients with ischemic heart disease. Inotropic state of the left ventricle during treatment with perhexiline maleate and with propranolol. Japanese heart journal, 1977, Volume: 18, Issue:4 Topics: Aged; Blood Pressure; Coronary Disease; Electrocardiography; Female; Hand; Heart Rate; Humans; Isometric Contraction; Male; Middle Aged; Perhexiline; Physical Exertion; Piperidines; Placebos; Propranolol	1977
Effects of perhexiline on myocardial phosphorylase activity, myocardial catecholamine content and heart rate. Japanese circulation journal, 1981, Volume: 45, Issue:6 Topics: Animals; Catecholamines; Heart Rate; Isoproterenol; Male; Myocardium; Norepinephrine; Perhexiline; Phosphorylase Kinase; Piperidines; Propranolol; Rats	1981
Effects of perhexiline on hemodynamics in anesthetized open-chest dogs. Japanese heart journal, 1981, Volume: 22, Issue:6 Topics: Anesthesia; Animals; Blood Circulation; Blood Flow Velocity; Blood Pressure; Cardiac Output; Dogs; Dose-Response Relationship, Drug; Female; Heart Rate; Hemodynamics; Male; Norepinephrine; Perhexiline; Phentolamine; Piperidines; Propranolol; Verapamil	1981
A new hepatoma cell line for toxicity testing at repeated doses. Cell biology and toxicology, 2003, Volume: 19, Issue:2 Topics: Acetaminophen; Aspirin; Carcinoma, Hepatocellular; Cell Line, Tumor; Dose-Response Relationship, Drug; Humans; Liver Neoplasms; Perhexiline; Propranolol; Toxicity Tests	2003