perhexiline has been researched along with perhexiline maleate in 65 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 44 (67.69) | 18.7374 |
| 1990's | 5 (7.69) | 18.2507 |
| 2000's | 6 (9.23) | 29.6817 |
| 2010's | 8 (12.31) | 24.3611 |
| 2020's | 2 (3.08) | 2.80 |
| Authors | Studies |
|---|---|
| Myers, JB | 1 |
| Beaugrand, M; Callard, P; Lageron, A | 1 |
| Maurer, R; Satz, N; Spycher, MA; Streuli, R; Täuber, M | 1 |
| Antman, EM; Beamer, AD; Benfell, K; Cantillon, CO; Cole, PL; Hartley, LH; Kelly, RA; McGowan, N; Smith, TW | 1 |
| Ingham, G; Kerr, GD | 1 |
| Chevron, M; Dayan, J; Deguingand, S; Truzman, C | 1 |
| Gueble-Val, F; Guenet, L; Le Gall, JY; Le Treut, A; Leray, G; Shacoori, V | 1 |
| Chevaleraud, JP; Hamard, H | 1 |
| Candide, C; Lageron, A; Mazière, C; Mazière, JC; Polonovski, J | 1 |
| Foster, BJ; Grotzinger, KR; Hamilton, TC; McKoy, WM; Rubinstein, LV | 1 |
| Collado, PS; Esteller, A; Gonzalez, J; Mariscal, MA; Muñoz, ME | 1 |
| Batt, AM; Decolin, D; Siest, G; Ziegler, JM | 1 |
| Goble, AJ; Horowitz, JD; Louis, WJ; Macdonald, PS; Sia, ST | 1 |
| Amoah, AG; Gould, BJ; Lockhart, JD; Parke, DV | 1 |
| Cooper, JD; Lockhart, JD; Matenga, J; Paul, R; Pilcher, J; Turnell, DC | 1 |
| Cooper, JD; Lockhart, D; Pilcher, J; Turnell, DC | 1 |
| Meng, HP; Zhang, BH | 1 |
| Carabott, F; Heathfield, KW | 1 |
| Dawes, P; Moulder, C | 1 |
| Lowe, JB; White, HD | 1 |
| Bousser, MG; Laplane, D | 1 |
| Gordon, AS; Gordon, M | 1 |
| Gautier, M; Lageron, A; Scotto, J | 1 |
| Idle, JR; Lockhart, JD; Oates, NS; Shah, RR; Smith, RL | 1 |
| Albouz, S; Baumann, N; Boutry, JM; Escourolle, R; Harpin, ML; Hauw, JJ; Mussini, JM; Pollet, S | 1 |
| Albouz, S; Bajolet, A; Baumann, N; Caulet, T; Pluot, M; Turpin, JC | 1 |
| Lorentz, IT; Shortall, M | 1 |
| Glaubiger, D; Ramu, A; Shan, TC | 1 |
| Gwynne, JF; Hay, DR | 1 |
| Fuks, Z; Gatt, S; Glaubiger, D; Ramu, A | 1 |
| Cooper, RG; Evans, DA; Whibley, EJ | 1 |
| Fielder, AR; Garner, A; Gibson, JM; Millac, P | 1 |
| Linares Rodríguez, A; Recarte Alvarez, J; Rodrigo Sáez, L; Valerdiz Casasola, S | 1 |
| Coulter, DM | 1 |
| Malicier, D; Rouzioux, JM | 1 |
| Méthé, M; Miller, D; Szlachcic, J; Taeymans, Y; Théroux, P; Waters, DD | 1 |
| Rees, JR | 1 |
| Dunn, D; Pieterse, AS; Rowland, R | 1 |
| Ikram, H; Maslowski, AH | 1 |
| Evreux, JC; Léry, N; Paliard, P | 1 |
| Seeff, LB | 1 |
| Goble, AJ; Horowitz, JD; White, HD | 1 |
| Colman, J; Mandelcorn, M; Murphy, J | 1 |
| Bendirdjian, JP; Bichara, M; Fillastre, JP; Foucher, B; Viotte, G | 1 |
| Boucard, M; François, C; Michel, H; Sablier, G; Sentein, P; Vic, P | 1 |
| Albouz, S; Baumann, N; Bourdon, R; Boutry, JM; Dubois, G; Hauw, JJ | 1 |
| Girre, A; Rault, B; Saiag, B; Shacoori, V | 1 |
| Colen, A; Dernier, J; Mancaux, A; Williame, E | 1 |
| Breit, SN; Bursill, JA; Campbell, TJ; Qiu, MR; Singleton, CB; Tie, H; Valenzuela, SM; Walker, BD; Wyse, KR | 1 |
| Kumamoto, T | 1 |
| Kohama, T; Koishi, R; Serizawa, N; Yoshimura, C | 1 |
| Inglis, S; Stewart, S | 1 |
| Coller, JK; Davies, BJ; Herbert, MK; Horowitz, JD; Inglis, SC; James, HM; Milne, RW; Morris, RG; Sallustio, BC; Somogyi, AA | 1 |
| Berson, A; Descatoire, V; Pessayre, D; Robin, MA | 1 |
| Biedermann, T; Goetz, F; Lang, F; Matzner, N; Shumilina, E; Xuan, NT; Zemtsova, IM | 1 |
| Lai, B | 1 |
| Frenneaux, MP; Gilutz, H; Horowitz, JD | 1 |
| Ishiguro, N; Ito, M; Katagiri, T; Kawai, T; Kitoh, H; Masuda, A; Matsushita, M; Ohno, K; Yamamoto, R | 1 |
| Achiwa, M; Horowitz, JD; Ishiguro, N; Kadono, I; Kaneko, H; Kitoh, H; Matsushita, M; Mishima, K; Ohno, K; Sallustio, BC | 1 |
| Cammue, BP; Chaltin, P; De Brucker, K; Delattin, N; Marchand, A; Meert, E; Thevissen, K; Vandamme, K | 1 |
| Florio, T; Garbati, P; Longo, L; Pagano, A; Penna, I; Pioggia, G; Rossi, F; Vella, S | 1 |
| Chong, CR; Horowitz, JD; Sallustio, B | 1 |
| Bolasco, G; Bresciani, A; Guidi, A; Lalli, C; Monteagudo, E; Nibbio, M; Perlas, E; Ruberti, G | 1 |
| Campiani, G; Gemma, S; Gimmelli, R; Guidi, A; Prasanth Saraswati, A; Relitti, N; Ruberti, G; Saccoccia, F; Sirignano, C; Taglialatela-Scafati, O | 1 |
| Bresciani, A; Cicero, DO; Di Pietro, G; Fustaino, V; Gimmelli, R; Guidi, A; Lentini, S; Petrella, G; Ruberti, G; Saccoccia, F | 1 |
7 review(s) available for perhexiline and perhexiline maleate
| Article | Year |
|---|---|
Polyneuropathy during perhexiline maleate therapy.
Topics: Electromyography; Humans; Neural Conduction; Perhexiline; Peripheral Nervous System Diseases; Polyneuropathies | 1981 |
Enhancement of doxorubicin and vinblastine sensitivity in anthracycline-resistant P388 cells.
Topics: Animals; Calcium Channel Blockers; Cell Line; Doxorubicin; Drug Resistance; Leukemia P388; Leukemia, Experimental; Membrane Lipids; Mice; Perhexiline; Vinblastine | 1983 |
[Hepatitis caused by drugs. 5].
Topics: Chemical and Drug Induced Liver Injury; Chlorpromazine; Deoxyepinephrine; Erythromycin; Gold; Humans; Hypoglycemic Agents; Oxacillin; Oxyphenisatin Acetate; Perhexiline; Phenylbutazone; Prognosis; Propylthiouracil | 1982 |
Drug-induced chronic liver disease, with emphasis on chronic active hepatitis.
Topics: Biopsy; Chemical and Drug Induced Liver Injury; Chlorpromazine; Dantrolene; Diagnosis, Differential; Fat Necrosis; Female; Hepatitis, Viral, Human; Humans; Liver Cirrhosis, Biliary; Male; Methotrexate; Methyldopa; Middle Aged; Nitrofurantoin; Oxyphenisatin Acetate; Perhexiline | 1981 |
[Amphiphilic cationic drug myopathy, drug-induced lysosomal storage lipidosis].
Topics: Aminoquinolines; Amiodarone; Animals; Anti-Arrhythmia Agents; Antimalarials; Autophagy; Cations; Chloroquine; Diagnosis, Differential; Humans; Hydroxychloroquine; Lysosomes; Muscle, Skeletal; Muscular Diseases; Perhexiline; Prognosis; Vacuoles | 2001 |
Metabolic therapeutics in angina pectoris: history revisited with perhexiline.
Topics: Acetanilides; Angina Pectoris; Calcium Channel Blockers; Cardiovascular Agents; Carnitine O-Palmitoyltransferase; Drug Monitoring; Epoxy Compounds; Fatty Acids; Half-Life; Humans; Metabolic Clearance Rate; Nurse's Role; Nursing Assessment; Patient Education as Topic; Patient Selection; Perhexiline; Piperazines; Randomized Controlled Trials as Topic; Ranolazine; Treatment Outcome; Trimetazidine; Vasodilator Agents | 2006 |
Drugs that Affect Cardiac Metabolism: Focus on Perhexiline.
Topics: Angina Pectoris; Animals; Cardiovascular Agents; Fatty Acids; Glucose; Humans; Mitochondria; Myocardium; Perhexiline | 2016 |
2 trial(s) available for perhexiline and perhexiline maleate
| Article | Year |
|---|---|
Efficacy and safety of perhexiline maleate in refractory angina. A double-blind placebo-controlled clinical trial of a novel antianginal agent.
Topics: Aged; Angina Pectoris; Clinical Trials as Topic; Double-Blind Method; Exercise Test; Female; Half-Life; Humans; Male; Middle Aged; Perhexiline; Prospective Studies | 1990 |
[Drug monitoring and liver diseases induced by perhexiline maleate].
Topics: Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; France; Humans; Perhexiline; Piperidines | 1981 |
56 other study(ies) available for perhexiline and perhexiline maleate
| Article | Year |
|---|---|
Prevalence of perhexiline maleate neurotoxicosis.
Topics: Humans; Nervous System Diseases; Perhexiline | 1979 |
[The liver and perhexiline maleate].
Topics: Chemical and Drug Induced Liver Injury; Humans; Liver; Perhexiline; Piperidines | 1979 |
Perhexiline maleate-induced hepatitis.
Topics: Angina Pectoris; Biopsy; Chemical and Drug Induced Liver Injury; Debrisoquin; Humans; Liver; Male; Microscopy, Electron; Middle Aged; Perhexiline; Time Factors | 1991 |
Torsade de pointes associated with perhexiline maleate therapy.
Topics: Aged; Electrocardiography; Humans; Male; Perhexiline; Torsades de Pointes | 1990 |
Application of the SOS chromotest to 10 pharmaceutical agents.
Topics: 5-Amino-3-((5-nitro-2-furyl)vinyl)-1,2,4-oxadiazole; DDT; Diethylstilbestrol; DNA Repair; Escherichia coli; Hydroxybenzoates; Metronidazole; Mutagenicity Tests; Mutagens; Nitrofurans; Perhexiline; Phenacetin; Quercetin; SOS Response, Genetics; Ticrynafen; Urethane | 1987 |
Inhibition of (Na+,K+)-ATPase and Mg++-ATPase by a lysosomotropic drug: perhexiline maleate.
Topics: Animals; Brain; Ca(2+) Mg(2+)-ATPase; Lysosomes; Perhexiline; Rats; Rats, Inbred Strains; Sodium-Potassium-Exchanging ATPase | 1988 |
[Optic neuropathies].
Topics: Anti-Bacterial Agents; Antineoplastic Agents; Antitubercular Agents; Central Nervous System Agents; Clioquinol; Humans; Optic Atrophy; Optic Nerve Diseases; Optic Neuritis; Papilledema; Perhexiline | 1985 |
The effects of perhexiline maleate on low density lipoprotein processing and cholesterol metabolism in cultured human fibroblasts.
Topics: Cells, Cultured; Cholesterol; Fibroblasts; Humans; Iodine Radioisotopes; Lipoproteins, LDL; Perhexiline; Sterol O-Acyltransferase | 1988 |
Modulation of induced resistance to adriamycin in two human breast cancer cell lines with tamoxifen or perhexiline maleate.
Topics: Breast Neoplasms; Cell Line; Doxorubicin; Drug Interactions; Drug Resistance; Fluorouracil; Humans; Melphalan; Methotrexate; Perhexiline; Tamoxifen; Tumor Stem Cell Assay; Vinblastine | 1988 |
Impairment of sulfobromophthalein biliary excretion and inhibition of glutathione S-transferase activity induced by perhexiline maleate in rats.
Topics: Animals; Bile; Glutathione; Glutathione Transferase; Kinetics; Liver; Male; Perhexiline; Rats; Rats, Inbred Strains; Sulfobromophthalein | 1988 |
Interactions of perhexiline maleate and arylalkylamine derivatives with cytochrome P-450 and in-vitro hydroxylation.
Topics: Animals; Benzhydryl Compounds; Cyclohexanes; Cytochrome P-450 Enzyme System; Hydroxylation; Kinetics; Male; Microsomes, Liver; Perhexiline; Phenethylamines; Phenobarbital; Rats; Rats, Inbred Strains | 1986 |
Perhexiline maleate treatment for severe angina pectoris--correlations with pharmacokinetics.
Topics: Adult; Aged; Angina Pectoris; Angina, Unstable; Drug Administration Schedule; Female; Humans; Kinetics; Male; Middle Aged; Perhexiline; Prospective Studies; Time Factors | 1986 |
Further studies on the pharmacokinetics of perhexiline maleate in humans.
Topics: Adult; Female; Half-Life; Humans; Kinetics; Male; Perhexiline | 1986 |
Investigations of long-term treatment with perhexiline maleate using therapeutic monitoring and electromyography.
Topics: Adult; Aged; Angina Pectoris; Electromyography; Female; Humans; Male; Middle Aged; Monitoring, Physiologic; Perhexiline | 1985 |
Therapeutic monitoring of the anti-anginal drug perhexiline maleate.
Topics: Angina Pectoris; Humans; Male; Perhexiline | 1985 |
[Cardiovascular effects of N-ethyl perhexiline maleate in animals].
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Dogs; Guinea Pigs; Heart Rate; Hemodynamics; Myocardium; Oxygen Consumption; Perhexiline; Rabbits; Rats | 1985 |
Adverse effects of perhexiline.
Topics: Adult; Aged; Angina Pectoris; Female; Humans; Liver Cirrhosis; Male; Perhexiline; Peripheral Nervous System Diseases; Piperidines | 1982 |
Perhexiline hepatitis and HLA-B8.
Topics: Angina Pectoris; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Female; Genes; Hepatitis, Alcoholic; HLA Antigens; HLA-B Antigens; Humans; Middle Aged; Perhexiline; Piperidines | 1982 |
Antianginal efficacy of perhexiline maleate in patients refractory to beta-adrenoreceptor blockade.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Angina Pectoris; Double-Blind Method; Drug Resistance; Humans; Male; Middle Aged; Perhexiline; Piperidines | 1983 |
Perhexiline maleate as a cause of reversible parkinsonism and peripheral neuropathy.
Topics: Aged; Angina Pectoris; Female; Humans; Parkinson Disease, Secondary; Perhexiline; Peripheral Nervous System Diseases; Piperidines | 1981 |
Effects of Pexid on liver cell cultures. Ultrastructural and histoenzymological studies.
Topics: Cells, Cultured; Gangliosides; Glycogen; Humans; Inclusion Bodies; Lipid Metabolism; Liver; Microscopy, Electron; Perhexiline; Piperidines | 1981 |
Impaired oxidation of debrisoquine in patients with perhexiline neuropathy.
Topics: Adult; Aged; Alcohol Drinking; Angina Pectoris; Debrisoquin; Female; Humans; Isoquinolines; Liver Function Tests; Male; Middle Aged; Oxidation-Reduction; Perhexiline; Peripheral Nervous System Diseases; Piperidines; Smoking | 1982 |
Perhexiline maleate induced lipidosis in human peripheral nerve and tissue culture: ultrastructural and biochemical changes.
Topics: Cells, Cultured; Fibroblasts; Humans; Lipidoses; Perhexiline; Peripheral Nerves; Peripheral Nervous System Diseases; Piperidines | 1981 |
[Study of thesaurismosis induced by perhexiline maleate. Confirmation of experimental data].
Topics: Cerebellar Ataxia; Female; Humans; Lipidoses; Middle Aged; Neuromuscular Diseases; Perhexiline; Peripheral Nerves; Peripheral Nervous System Diseases; Piperidines; Schwann Cells | 1983 |
Perhexilene neuropathy: a report of two cases.
Topics: Angina Pectoris; Female; Humans; Leg; Male; Middle Aged; Neural Conduction; Pain; Paresthesia; Perhexiline; Peripheral Nervous System Diseases | 1983 |
Cirrhosis of the liver following therapy with perhexiline maleate.
Topics: Humans; Liver; Liver Cirrhosis; Male; Middle Aged; Perhexiline; Piperidines | 1983 |
Reversal of acquired resistance to doxorubicin in P388 murine leukemia cells by perhexiline maleate.
Topics: Animals; Biological Transport; Cell Division; Cell Survival; Daunorubicin; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance; Kinetics; Leukemia P388; Leukemia, Experimental; Mice; Mice, Inbred Strains; Perhexiline; Vinblastine | 1984 |
Polymorphic hydroxylation of perhexiline maleate in man.
Topics: Adult; Alleles; Female; Humans; Hydroxylation; Male; Middle Aged; Perhexiline; Phenotype; Polymorphism, Genetic | 1984 |
Severe ocular side effects of perhexilene maleate: case report.
Topics: Conjunctiva; Epithelium; Fluorescein Angiography; Humans; Male; Microscopy, Electron; Middle Aged; Papilledema; Perhexiline; Vision Disorders | 1984 |
Study of reasons for cessation of therapy with perhexiline maleate, sodium valproate and labetalol in the intensified adverse reaction reporting scheme.
Topics: Data Collection; Ethanolamines; Humans; Labetalol; Perhexiline; Piperidines; Surveys and Questionnaires; Valproic Acid | 1981 |
[Calling into question medical responsibility in a death following prolonged treatment with perhexiline maleate].
Topics: France; Humans; Liver Cirrhosis; Long-Term Care; Male; Malpractice; Middle Aged; Perhexiline; Piperidines | 1982 |
[Usefulness of 24-hour electrocardiographic monitoring in the treatment of patients with Prinzmetal's angina].
Topics: Angina Pectoris, Variant; Calcium Channel Blockers; Coronary Vasospasm; Electrocardiography; Humans; Nitrates; Perhexiline | 1983 |
Perhexiline: good for refractory angina but take care!
Topics: Angina Pectoris; Humans; Perhexiline; Piperidines; Premedication | 1983 |
Perhexiline maleate induced cirrhosis.
Topics: Aged; Angina Pectoris; Female; Humans; Liver; Liver Cirrhosis; Perhexiline; Piperidines | 1983 |
Unstable angina and perhexilene maleate.
Topics: Angina Pectoris; Humans; Perhexiline; Piperidines | 1981 |
Liver disease induced by perhexiline maleate.
Topics: Chemical and Drug Induced Liver Injury; Perhexiline; Piperidines | 1982 |
Papilledema without peripheral neuropathy in a patient taking perhexiline maleate.
Topics: Adult; Angina Pectoris; Fluorescein Angiography; Humans; Male; Papilledema; Perhexiline; Piperidines; Visual Fields | 1982 |
Changes in the lysosomes and mitochondria isolated from the liver, kidney and heart of rats treated with perhexiline maleate.
Topics: Acetylglucosaminidase; Animals; Heart; In Vitro Techniques; Kidney; Liver; Lysosomes; Male; Mitochondria; Mitochondria, Heart; Mitochondria, Liver; Perhexiline; Piperidines; Rats; Rats, Inbred Strains | 1982 |
[Comparative hepatic toxicity of perhexiline maleate and griseofulvin in mice].
Topics: Animals; Chemical and Drug Induced Liver Injury; Griseofulvin; Liver; Male; Mice; Perhexiline; Piperidines; Time Factors | 1981 |
Lipid and lysosomal enzymes in human fibroblasts cultured with perhexiline maleate.
Topics: Cells, Cultured; Cholesterol; Fibroblasts; Gangliosides; Humans; Lipid Metabolism; Lysosomes; Perhexiline; Phospholipids; Piperidines | 1981 |
Stimulatory effect of perhexiline maleate on the basal and LHRH-stimulated luteinizing hormone release from rat pituitary cell aggregates in vitro.
Topics: Animals; Cells, Cultured; Dose-Response Relationship, Drug; Gonadotropin-Releasing Hormone; Luteinizing Hormone; Male; Perhexiline; Pituitary Gland, Anterior; Rats; Rats, Wistar | 1995 |
[Neuropathies due to perhexiline maleate and their electromyographic diagnosis].
Topics: Aged; Electromyography; Humans; Neural Conduction; Paresthesia; Perhexiline; Peripheral Nervous System Diseases; Vasodilator Agents | 1980 |
Inhibition of HERG channels stably expressed in a mammalian cell line by the antianginal agent perhexiline maleate.
Topics: Algorithms; Animals; Anti-Arrhythmia Agents; Cardiovascular Agents; Cation Transport Proteins; CHO Cells; Cricetinae; Electric Stimulation; Ether-A-Go-Go Potassium Channels; In Vitro Techniques; Membrane Potentials; Oocytes; Patch-Clamp Techniques; Perhexiline; Piperidines; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Xenopus laevis | 1999 |
Leustroducsin B activates nuclear factor-kappaB via the acidic sphingomyelinase pathway in human bone marrow-derived stromal cell line KM-102.
Topics: Acetylcysteine; Antioxidants; Bone Marrow Cells; Bridged-Ring Compounds; Cell Line; Clone Cells; Desipramine; Genes, Reporter; Humans; Interleukin-11; Interleukin-8; Lactones; Mutagenesis, Site-Directed; NF-kappa B; Norbornanes; Organophosphorus Compounds; Perhexiline; Phosphodiesterase Inhibitors; Point Mutation; Promoter Regions, Genetic; Protein Processing, Post-Translational; Pyrones; Signal Transduction; Sphingomyelin Phosphodiesterase; Stromal Cells; Thiocarbamates; Thiones; Transcriptional Activation | 2002 |
Effect of CYP2D6 metabolizer status on the disposition of the (+) and (-) enantiomers of perhexiline in patients with myocardial ischaemia.
Topics: Biological Availability; Cardiovascular Agents; Cytochrome P-450 CYP2D6; Genotype; Humans; Metabolic Clearance Rate; Myocardial Ischemia; Perhexiline; Phenotype; Polymorphism, Genetic; Prospective Studies; Retrospective Studies; Sensitivity and Specificity; Stereoisomerism | 2007 |
Steatohepatitis-inducing drugs trigger cytokeratin cross-links in hepatocytes. Possible contribution to Mallory-Denk body formation.
Topics: Amiodarone; Animals; Calcium; Fatty Liver; GTP-Binding Proteins; Hepatocytes; Hexestrol; Inclusion Bodies; Keratin-8; Male; Malondialdehyde; Perhexiline; Protein Glutamine gamma Glutamyltransferase 2; Proteins; Rats; Rats, Sprague-Dawley; Transglutaminases | 2008 |
Ca2+-dependent functions in peptidoglycan-stimulated mouse dendritic cells.
Topics: Animals; Calcium; Calcium Channel Blockers; Cells, Cultured; Cytokines; Dendritic Cells; Dose-Response Relationship, Drug; Drug Combinations; Electrophysiology; Female; Femur; Fluorescent Dyes; Fura-2; Imidazoles; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Neurotoxins; Patch-Clamp Techniques; Peptidoglycan; Perhexiline; Phagocytosis; Potassium Channels, Voltage-Gated; Scorpion Venoms; Staphylococcus aureus; Tibia; Toll-Like Receptor 2 | 2009 |
Hypoglycaemia after treatment with perhexiline maleate: a case report.
Topics: Aged, 80 and over; Blood Glucose; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Electrocardiography; Follow-Up Studies; Humans; Hypoglycemia; Male; Myocardial Infarction; Perhexiline; Risk Assessment; Severity of Illness Index | 2011 |
A case series of concomitant treatment of perhexiline with amiodarone.
Topics: Adult; Aged; Aged, 80 and over; Amiodarone; Blood Glucose; Carnitine O-Palmitoyltransferase; Databases, Factual; Drug Interactions; Drug Therapy, Combination; Female; gamma-Glutamyltransferase; Humans; Male; Middle Aged; Perhexiline; Prevalence; Retrospective Studies; Vasodilator Agents | 2012 |
Clinically applicable antianginal agents suppress osteoblastic transformation of myogenic cells and heterotopic ossifications in mice.
Topics: Activin Receptors, Type I; Animals; Bone Morphogenetic Protein 2; Calcium Channel Blockers; Cell Line; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Fendiline; Inhibitor of Differentiation Protein 1; Mice; Mice, Mutant Strains; Muscle Cells; Mutation; Myositis Ossificans; Ossification, Heterotopic; Osteoblasts; Perhexiline; Promoter Regions, Genetic; Smad Proteins | 2013 |
Perhexiline maleate in the treatment of fibrodysplasia ossificans progressiva: an open-labeled clinical trial.
Topics: Adolescent; Adult; Alkaline Phosphatase; Female; Humans; Male; Myositis Ossificans; Osteocalcin; Perhexiline; Radiography; Young Adult | 2013 |
Repurposing as a means to increase the activity of amphotericin B and caspofungin against Candida albicans biofilms.
Topics: Amphotericin B; Androstenes; Animals; Antifungal Agents; Biofilms; Caenorhabditis elegans; Candida albicans; Caspofungin; Drug Repositioning; Drug Synergism; Echinocandins; Lipopeptides; Microbial Sensitivity Tests; Osteoblasts; Perhexiline; Toremifene | 2014 |
Perhexiline maleate enhances antitumor efficacy of cisplatin in neuroblastoma by inducing over-expression of NDM29 ncRNA.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; ATP-Binding Cassette Transporters; Cell Line, Tumor; Cell Survival; Cisplatin; Drug Synergism; Gene Expression Regulation, Neoplastic; Humans; Mice, Inbred NOD; Mice, SCID; Neuroblastoma; Perhexiline; Reverse Transcriptase Polymerase Chain Reaction; RNA, Untranslated; Survival Analysis; Tumor Burden; Xenograft Model Antitumor Assays | 2015 |
Discovery and Characterization of Novel Anti-schistosomal Properties of the Anti-anginal Drug, Perhexiline and Its Impact on Schistosoma mansoni Male and Female Reproductive Systems.
Topics: Animals; Disease Models, Animal; Drug Resistance; Female; Genitalia; Half-Life; Humans; Life Cycle Stages; Male; Mice; Mice, Inbred C57BL; Perhexiline; Praziquantel; Schistosoma mansoni; Schistosomiasis mansoni; Schistosomicides | 2016 |
(+)-(R)- and (-)-(S)-Perhexiline maleate: Enantioselective synthesis and functional studies on Schistosoma mansoni larval and adult stages.
Topics: Animals; Larva; Molecular Structure; Perhexiline; Schistosoma mansoni; Stereoisomerism; Structure-Activity Relationship | 2020 |
Drug effects on metabolic profiles of Schistosoma mansoni adult male parasites detected by 1H-NMR spectroscopy.
Topics: Adult; Animals; Anthelmintics; Drug Monitoring; Female; Humans; Male; Metabolome; Mice, Inbred ICR; Perhexiline; Praziquantel; Proton Magnetic Resonance Spectroscopy; Schistosoma mansoni; Schistosomiasis mansoni | 2020 |