perhexiline and amiodarone

perhexiline has been researched along with amiodarone in 41 studies

Research

Studies (41)

Timeframe	Studies, this research(%)	All Research%
pre-1990	14 (34.15)	18.7374
1990's	3 (7.32)	18.2507
2000's	8 (19.51)	29.6817
2010's	15 (36.59)	24.3611
2020's	1 (2.44)	2.80

Authors

Authors	Studies
Keserü, GM	1
Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J	1
Jia, L; Sun, H	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Glen, RC; Lowe, R; Mitchell, JB	1
Ekins, S; Williams, AJ; Xu, JJ	1
Sen, S; Sinha, N	1
Arduini, A; Ceccarelli, SM; Chomienne, O; Gubler, M	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Atzpodien, EA; Csato, M; Doessegger, L; Fischer, H; Lenz, B; Schmitt, G; Singer, T	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y	1
Rivier, JL	1
Beaughard, M; Cosnier, D; Labrid, C; Piris, P	1
Bady, B; Bourrat, C; Carrier, H; Girard, PF; Trillet, M	1
De'Thomatis, M; Falciola, N; Gallesio, R	1
Bregetzer, J	1
Boucher, M; Duchene-Marullaz, D	1
Bickert, P; Rullière, R	1
Combes, P; Fargnoli, JM; Richard, M	1
Lauterburg, BH	1
Charlier, R	1
Bouhour, JB; Godin, JF; Nicolas, G	1
Vacheron, A	1
Cheucle-Beaughard, M; Duchene-Marullaz, P; Michelin, MT	1
Lüllmann-Rauch, R	1
Horowitz, JD; Kennedy, JA; Unger, SA	1
Chirkov, YY; Chirkova, LP; Horowitz, JD; Kennedy, JA; Murphy, GA; Willoughby, SR	1
Horowitz, JD; Kennedy, JA	1
Kumamoto, T	1
Sanyal, AJ; Stravitz, RT	1
Berson, A; Descatoire, V; Pessayre, D; Robin, MA	1
Balgi, AD; Donohue, E; Fonseca, BD; Lajoie, P; Nabi, IR; Proud, CG; Roberge, M; Tsang, TC	1
Chirkov, YY; Horowitz, JD; Kennedy, JA; Sverdlov, AL	1
Frenneaux, MP; Gilutz, H; Horowitz, JD	1
Larrain, S; Rinella, ME	1
Guo, GL; Schumacher, JD	1
Sia, P; Simon, S; Tan, Y	1

Reviews

12 review(s) available for perhexiline and amiodarone

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
[Toxic neurologic manifestations during angina pectoris treatment (perhexiline maleate and amiotadone hydrochloride)]. International journal of neurology, 1978, Volume: 11, Issue:4 Topics: Amiodarone; Angina Pectoris; Benzofurans; Cerebrospinal Fluid Proteins; Electromyography; Humans; Inclusion Bodies; Lipid Metabolism; Microscopy, Electron; Movement Disorders; Muscles; Nervous System Diseases; Paresthesia; Perhexiline; Peripheral Nerves; Peripheral Nervous System Diseases; Pigments, Biological; Piperidines; Polyradiculoneuropathy; Schwann Cells; Skin; Tremor	1978
[Medical therapy of chronic coronary insufficiency]. Bollettino della Societa italiana di cardiologia, 1978, Volume: 23, Issue:5 Topics: Amiodarone; Angina Pectoris; Chronic Disease; Coronary Disease; Digitalis Glycosides; Humans; Lidoflazine; Oxyfedrine; Perhexiline; Practolol; Prenylamine; Verapamil	1978
[Drug damage to the liver: role of reactive metabolites and pharmacokinetics]. Schweizerische medizinische Wochenschrift, 1985, Sep-21, Volume: 115, Issue:38 Topics: Acetaminophen; Amiodarone; Chemical and Drug Induced Liver Injury; Drug-Related Side Effects and Adverse Reactions; Erythromycin; Glutathione; Halothane; Humans; Isoniazid; Liver; Perhexiline; Valproic Acid	1985
[Physiopathology of angina and long term antianginal medication. Current concepts]. La Nouvelle presse medicale, 1974, Nov-02, Volume: 3, Issue:37 Topics: Adrenergic beta-Antagonists; Amiodarone; Angina Pectoris; Blood Flow Velocity; Cardiac Output; Coronary Circulation; Follow-Up Studies; Heart; Heart Rate; Humans; Long-Term Care; Maleates; Nitrates; Oxygen Consumption; Perhexiline; Vasodilator Agents	1974
[Strategy of the medical treatment of angina pectoris]. Archives des maladies du coeur et des vaisseaux, 1983, Volume: 76 Spec No Topics: Adrenergic beta-Antagonists; Adult; Aged; Aging; Amiodarone; Angina Pectoris; Calcium Channel Blockers; Humans; Life Style; Middle Aged; Nitroglycerin; Perhexiline; Risk; Socioeconomic Factors	1983
Experimentally induced lipidosis in rat retinal pigment epithelium. A brief review. Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. Albrecht von Graefe's archive for clinical and experimental ophthalmology, 1981, Volume: 215, Issue:4 Topics: Amiodarone; Animals; Chloroquine; Chlorphentermine; Imipramine; Lipidoses; Microscopy, Electron; Perhexiline; Pigment Epithelium of Eye; Rats	1981
[Amphiphilic cationic drug myopathy, drug-induced lysosomal storage lipidosis]. Ryoikibetsu shokogun shirizu, 2001, Issue:36 Topics: Aminoquinolines; Amiodarone; Animals; Anti-Arrhythmia Agents; Antimalarials; Autophagy; Cations; Chloroquine; Diagnosis, Differential; Humans; Hydroxychloroquine; Lysosomes; Muscle, Skeletal; Muscular Diseases; Perhexiline; Prognosis; Vacuoles	2001
Drug-induced steatohepatitis. Clinics in liver disease, 2003, Volume: 7, Issue:2 Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Antineoplastic Agents, Hormonal; Calcium Channel Blockers; Fatty Liver; Hexestrol; Humans; Perhexiline	2003
Modulation of myocardial metabolism: an emerging therapeutic principle. Current opinion in cardiology, 2010, Volume: 25, Issue:4 Topics: Acetanilides; Amiodarone; Cardiovascular Agents; Heart Failure; Humans; Hypertrophy, Left Ventricular; Myocardial Ischemia; Myocardial Perfusion Imaging; Myocardial Reperfusion; Myocardium; Perhexiline; Piperazines; Ranolazine; Trimetazidine; Vasodilator Agents	2010
A myriad of pathways to NASH. Clinics in liver disease, 2012, Volume: 16, Issue:3 Topics: Amiodarone; Anti-Retroviral Agents; Bacterial Infections; Cannabis; Diet; Fatty Liver; Genetic Diseases, Inborn; Glucocorticoids; Humans; Hypothyroidism; Insulin Resistance; Intestinal Diseases; Lipid Metabolism; Metabolic Syndrome; Methotrexate; Non-alcoholic Fatty Liver Disease; Occupational Diseases; Perhexiline	2012
Mechanistic review of drug-induced steatohepatitis. Toxicology and applied pharmacology, 2015, Nov-15, Volume: 289, Issue:1 Topics: Amiodarone; Animals; Camptothecin; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Fatty Liver; Hepatocytes; Humans; Irinotecan; Lipid Metabolism; Liver; Methotrexate; Mitochondria, Liver; Organoplatinum Compounds; Oxaliplatin; Perhexiline; Tamoxifen; Tetracycline; Valproic Acid	2015

Other Studies

29 other study(ies) available for perhexiline and amiodarone

Article	Year
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods. Bioorganic & medicinal chemistry letters, 2003, Aug-18, Volume: 13, Issue:16 Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship	2003
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model. Journal of medicinal chemistry, 2008, Jan-24, Volume: 51, Issue:2 Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase	2008
Support vector machines classification of hERG liabilities based on atom types. Bioorganic & medicinal chemistry, 2008, Jun-01, Volume: 16, Issue:11 Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve	2008
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
Predicting phospholipidosis using machine learning. Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5 Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model. European journal of medicinal chemistry, 2011, Volume: 46, Issue:2 Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship	2011
Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research. Journal of medicinal chemistry, 2011, May-12, Volume: 54, Issue:9 Topics: Animals; Carnitine; Carnitine O-Palmitoyltransferase; Catalytic Domain; Diabetes Mellitus, Type 2; Energy Metabolism; Enzyme Activators; Ethylene Oxide; Heart Failure; Humans; Insulin Resistance; Isoenzymes; Lipid Metabolism; Myocardial Ischemia; Organ Specificity; Protein Conformation; Sequence Homology, Amino Acid; Stereoisomerism	2011
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
In silico assay for assessing phospholipidosis potential of small druglike molecules: training, validation, and refinement using several data sets. Journal of medicinal chemistry, 2012, Jan-12, Volume: 55, Issue:1 Topics: Animals; Cattle; Cells, Cultured; Computer Simulation; Cornea; Drug-Related Side Effects and Adverse Reactions; Fibroblasts; Lipidoses; Lysosomal Storage Diseases; Models, Molecular; Pharmaceutical Preparations; Phospholipids; Structure-Activity Relationship; Thermodynamics	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships. Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16 Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone	2016
[General practicioner in face of angina pectoris (author's transl)]. Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1977, Feb-08, Volume: 66, Issue:6 Topics: Adrenergic beta-Antagonists; Amiodarone; Angina Pectoris; Diet, Reducing; Exercise Therapy; Family Practice; Humans; Isosorbide Dinitrate; Nitroglycerin; Perhexiline	1977
Activity of bepridil and other anti-anginals on cardiovascular modifications engendered by conditioned anxiety in the dog. Archives internationales de pharmacodynamie et de therapie, 1978, Volume: 235, Issue:1 Topics: Amines; Amiodarone; Angina Pectoris; Animals; Anxiety; Behavior, Animal; Benzylamines; Conditioning, Operant; Dipyridamole; Dogs; Female; Hemodynamics; Humans; Male; Nitroglycerin; Pentaerythritol Tetranitrate; Perhexiline; Propranolol; Pyrrolidines	1978
[Various new anti-angina medications]. Revue de l'infirmiere, 1977, Volume: 27, Issue:2 Topics: Amiodarone; Angina Pectoris; Benzofurans; Humans; Isosorbide Dinitrate; Perhexiline; Piperidines	1977
Comparative effects of amiodarone, perhexiline and bepridil on the cardiac rhythms of the unanesthetized dog in chronic heart block. Archives internationales de pharmacodynamie et de therapie, 1978, Volume: 233, Issue:1 Topics: Amines; Amiodarone; Animals; Benzofurans; Benzylamines; Dogs; Female; Heart Block; Heart Rate; Male; Perhexiline; Piperidines; Pyrrolidines; Time Factors	1978
[2 new anti-angina drugs: amiodarone and perhexiline maleate. Advantages and adverse effects]. La Revue du praticien, 1976, Dec-21, Volume: 26, Issue:59 Topics: Amiodarone; Angina Pectoris; Benzofurans; Humans; Perhexiline; Piperidines	1976
[Other drugs used in angina pectoris]. Soins. Cardiologie, 1985, Issue:34 Topics: Amiodarone; Angina Pectoris; Humans; Molsidomine; Perhexiline; Prenylamine; Sydnones; Vasodilator Agents	1985
[The classic anti-anginal agents and molsidomine]. Archives des maladies du coeur et des vaisseaux, 1983, Volume: 76 Spec No Topics: Amiodarone; Angina Pectoris; Angina Pectoris, Variant; Humans; Kinetics; Molsidomine; Oxadiazoles; Perhexiline; Stroke Volume; Sydnones; Thyroid Diseases	1983
Comparative effects of amiodarone, bepridil and perhexiline on coronary venous flow and several cardiovascular parameters. Archives internationales de pharmacodynamie et de therapie, 1980, Volume: 245, Issue:2 Topics: Amines; Amiodarone; Animals; Benzofurans; Benzylamines; Bepridil; Coronary Circulation; Denervation; Dogs; Female; Heart; Heart Rate; Hemodynamics; Male; Oxygen Consumption; Perhexiline; Piperidines; Pyrrolidines; Time Factors	1980
Inhibition of carnitine palmitoyltransferase-1 in rat heart and liver by perhexiline and amiodarone. Biochemical pharmacology, 1996, Jul-26, Volume: 52, Issue:2 Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Cardiovascular Agents; Carnitine O-Palmitoyltransferase; Male; Mitochondria, Heart; Mitochondria, Liver; Perhexiline; Rats; Rats, Sprague-Dawley; Subtilisins	1996
Inhibition of long-chain fatty acid metabolism does not affect platelet aggregation responses. European journal of pharmacology, 1998, Sep-04, Volume: 356, Issue:2-3 Topics: Adult; Aged; Amiodarone; Blood Platelets; Cardiovascular Agents; Carnitine O-Palmitoyltransferase; Case-Control Studies; Enzyme Inhibitors; Epoxy Compounds; Fatty Acids; Female; Humans; Male; Middle Aged; Perhexiline; Platelet Aggregation; Trimetazidine; Vasodilator Agents	1998
Effect of trimetazidine on carnitine palmitoyltransferase-1 in the rat heart. Cardiovascular drugs and therapy, 1998, Volume: 12, Issue:4 Topics: Amiodarone; Animals; Carnitine O-Palmitoyltransferase; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Mitochondria, Heart; Myocardial Ischemia; Myocardium; Perhexiline; Rats; Rats, Sprague-Dawley; Trimetazidine	1998
Steatohepatitis-inducing drugs trigger cytokeratin cross-links in hepatocytes. Possible contribution to Mallory-Denk body formation. Toxicology in vitro : an international journal published in association with BIBRA, 2008, Volume: 22, Issue:6 Topics: Amiodarone; Animals; Calcium; Fatty Liver; GTP-Binding Proteins; Hepatocytes; Hexestrol; Inclusion Bodies; Keratin-8; Male; Malondialdehyde; Perhexiline; Protein Glutamine gamma Glutamyltransferase 2; Proteins; Rats; Rats, Sprague-Dawley; Transglutaminases	2008
Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling. PloS one, 2009, Sep-22, Volume: 4, Issue:9 Topics: Acetophenones; Amiodarone; Antinematodal Agents; Automation; Autophagy; Benzopyrans; Cardiovascular Agents; Drug Evaluation, Preclinical; Enzyme Inhibitors; Humans; Mechanistic Target of Rapamycin Complex 1; Models, Chemical; Multiprotein Complexes; Niclosamide; Nutritional Sciences; Perhexiline; Proteins; Signal Transduction; TOR Serine-Threonine Kinases; Transcription Factors	2009
A case series of concomitant treatment of perhexiline with amiodarone. Therapeutic drug monitoring, 2012, Volume: 34, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Amiodarone; Blood Glucose; Carnitine O-Palmitoyltransferase; Databases, Factual; Drug Interactions; Drug Therapy, Combination; Female; gamma-Glutamyltransferase; Humans; Male; Middle Aged; Perhexiline; Prevalence; Retrospective Studies; Vasodilator Agents	2012
Optic neuropathy secondary to perhexiline and amiodarone. BMJ case reports, 2021, Jan-27, Volume: 14, Issue:1 Topics: Aged; Amiodarone; Fluorescein Angiography; Humans; Male; Optic Nerve Diseases; Perhexiline; Recurrence; Tomography, Optical Coherence; Vasodilator Agents	2021