Page last updated: 2024-09-03

perchlorate and thyroxine

perchlorate has been researched along with thyroxine in 39 studies

Compound Research Comparison

Studies
(perchlorate)
Trials
(perchlorate)
Recent Studies (post-2010)
(perchlorate)
Studies
(thyroxine)
Trials
(thyroxine)
Recent Studies (post-2010) (thyroxine)
768339638,9891,4106,550

Protein Interaction Comparison

ProteinTaxonomyperchlorate (IC50)thyroxine (IC50)
TransthyretinHomo sapiens (human)2.1939
UDP-glucuronosyltransferase 1A1 Homo sapiens (human)5.25
Solute carrier organic anion transporter family member 4C1Homo sapiens (human)8
Bile acid receptorHomo sapiens (human)7.86

Research

Studies (39)

TimeframeStudies, this research(%)All Research%
pre-19903 (7.69)18.7374
1990's0 (0.00)18.2507
2000's16 (41.03)29.6817
2010's18 (46.15)24.3611
2020's2 (5.13)2.80

Authors

AuthorsStudies
ENNECKER, C; KESSLER, FJ; KRUSKEMPER, HL1
TONG, W1
SCHOENBAUM, E; SELLERS, EA1
Bradford, CM; Carr, JA; Rinchard, J; Theodorakis, C1
Sato, K1
Degitz, SJ; Helbing, CC; Holcombe, GW; Kosian, PA; Tietge, J; Veldhoen, N; Zhang, F1
Beck, B; Blount, BC; Braverman, LE; Firek, A; He, X; Magnani, B; Pearce, EN; Pino, S; Seeley, M1
Carr, JA; Hu, F; Mukhi, S; Patiño, R; Sharma, B1
Blount, BC; Caldwell, KL; Osterloh, JD; Pirkle, JL; Valentin-Blasini, L1
Mukhi, S; Patiño, R; Torres, L1
Beccaria, L; Beck-Peccoz, P; Carletto, M; Cortinovis, F; Fugazzola, L; Longari, V; Mannavola, D; Persani, L; Vannucchi, G; Vigone, MC; Weber, G1
Howd, R; Miller, MD; Steinmaus, C1
Amitai, Y; Blount, BC; Fisher, N; Israeli, A; Leventhal, A; Lewis, M; Sack, J; Valentin-Blasini, L; Wasser, J; Winston, G1
Gilbert, ME; Sui, L1
Gibbs, JP; Van Landingham, C1
Bernardini, N; Botta, R; Calebiro, D; de Filippis, T; Fausto, AM; Giorgi, F; Ippolito, C; Lisi, S; Madsen, P; Marcocci, C; Marinò, M; Mattii, L; Persani, L; Petersen, CM; Pinchera, A; Taddei, AR1
Braunbeck, T; Grim, KC; Iguchi, T; Ohta, Y; Tietge, J; Tooi, O; Touart, L; Wolf, DC; Wolfe, M1
Andersen, ME; Campbell, JL; Fisher, JW; McLanahan, ED1
Braverman, LE; Pearce, EN1
Ferguson, DC; Gilbert, ME; Sharlin, DS; Taylor, MA; Zoeller, RT1
Colin, IM; Gérard, AC; Humblet, K; Poncin, S; Van Eeckoudt, S1
Calil-Silveira, J; Nunes, MT; Serrano-Nascimento, C2
Bestwick, JP; Braverman, LE; Burns, R; Dall'amico, D; He, X; Jooman, M; Lazarus, JH; Leung, AM; Maina, A; Parkes, AB; Pearce, EN; Smith, DF; Smyth, PP1
Degitz, SJ; Hornung, MW; Korte, LM; Kosian, PA; Linnum, AL; Olson, JM; Tietge, JE1
Padmanabhan, H1
Fisher, JW; Kannan, K; Kunisue, T1
Alevizaki, M; Alexiou, M; Braverman, LE; He, X; Ilias, I; Koukkou, E; Markou, KB; Pearce, EN1
Braverman, LE; He, X; Jahreis, KA; Leung, AM; Pearce, EN; Roussilhes, A; Schuller, KE1
Alwis, U; Blount, BC; Gold, EB; Kim, K; Lee, JS; O'Neill Rasor, M; Srivastav, A1
Patiño, R; Sharma, P1
Abraham, L; Hixon, JG; Proctor, DM; Suh, M1
Chen, HX; Ding, MH; Li, YG; Liu, Q; Peng, KL1
Charnley, G; Lewandowski, TA; Peterson, MK1
Adams, EM; Buck, CL; Cresko, WA; Dillon, DM; Gardell, AM; Petersen, AM; Postlethwait, JH; von Hippel, FA1
George, NI; Lumen, A1
Ghassabian, A; Kohn, B; McMullen, J; Trasande, L1
Chen, L; Huang, Y; Jiang, G; King, L; Li, W; Li, Y; Liang, X; Liu, L; Peng, X; Wang, P; Wang, Q; Xia, L1
Fisher, J; Gilbert, M; Housand, C; Mattie, D; Moreau, M; Nong, A1

Reviews

4 review(s) available for perchlorate and thyroxine

ArticleYear
[Drug (amiodarone)-induced thyroid disease].
    Nihon rinsho. Japanese journal of clinical medicine, 2005, Volume: 63 Suppl 10

    Topics: Amiodarone; Hormone Replacement Therapy; Humans; Hypothyroidism; Perchlorates; Prednisolone; Thyrotoxicosis; Thyroxine

2005
Environmental pollutants and the thyroid.
    Best practice & research. Clinical endocrinology & metabolism, 2009, Volume: 23, Issue:6

    Topics: Animals; Benzhydryl Compounds; Dioxins; Environmental Exposure; Environmental Pollutants; Female; Fetus; Halogenated Diphenyl Ethers; Humans; Hydrocarbons, Chlorinated; Iodide Peroxidase; Isoflavones; Lead; Liver; Nitrates; Perchlorates; Phenols; Polychlorinated Biphenyls; Pregnancy; Styrenes; Symporters; Thiocyanates; Thyroid Gland; Thyroxine; Triclosan

2009
Amiodarone and thyroid dysfunction.
    Southern medical journal, 2010, Volume: 103, Issue:9

    Topics: Amiodarone; Anti-Arrhythmia Agents; Antithyroid Agents; Continuity of Patient Care; Glucocorticoids; Hormone Replacement Therapy; Humans; Hypothyroidism; Iodine Radioisotopes; Methimazole; Perchlorates; Plasmapheresis; Risk Factors; Thyroid Gland; Thyroid Hormones; Thyroidectomy; Thyrotoxicosis; Thyroxine; Ultrasonography

2010
The effects of perchlorate, nitrate, and thiocyanate on free thyroxine for potentially sensitive subpopulations of the 2001-2002 and 2007-2008 National Health and Nutrition Examination Surveys.
    Journal of exposure science & environmental epidemiology, 2014, Volume: 24, Issue:6

    Topics: Environmental Pollutants; Female; Humans; Iodine; Male; Nitrates; Nutrition Surveys; Perchlorates; Pregnancy; Regression Analysis; Risk Factors; Thiocyanates; Thyroid Gland; Thyroxine; United States

2014

Trials

1 trial(s) available for perchlorate and thyroxine

ArticleYear
Effects of six months of daily low-dose perchlorate exposure on thyroid function in healthy volunteers.
    The Journal of clinical endocrinology and metabolism, 2006, Volume: 91, Issue:7

    Topics: Adult; Aged; Double-Blind Method; Female; Humans; Iodine; Iodine Radioisotopes; Male; Middle Aged; Perchlorates; Prospective Studies; Thyroglobulin; Thyroid Gland; Thyrotropin; Thyroxine; Triiodothyronine

2006

Other Studies

34 other study(ies) available for perchlorate and thyroxine

ArticleYear
[Effect of triiodothyronine & thyroxin on perchlorate goiter].
    Acta endocrinologica, 1958, Volume: 29, Issue:4

    Topics: Goiter; Perchlorates; Thyroxine; Triiodothyronine

1958
THYROTROPIN STIMULATION OF THYROXINE SYNTHESIS IN ISOLATED THYROID CELLS TREATED WITH PERCHLORATE.
    Endocrinology, 1964, Volume: 75

    Topics: Animals; Cattle; Chlorides; Diiodotyrosine; Metabolism; Perchlorates; Pharmacology; Pituitary Hormones, Anterior; Research; Thyroid Gland; Thyrotropin; Thyroxine

1964
FURTHER STUDIES ON THE GOITROGENIC ACTION OF THYROXINE ADMINISTERED WITH PROPYLTHIOURACIL, METHIMAZOLE OR PERCHLORATE.
    Acta endocrinologica, 1965, Volume: 49

    Topics: Antithyroid Agents; Body Weight; Iodine Isotopes; Methimazole; Organ Size; Perchlorates; Pharmacology; Pituitary Gland; Pituitary Hormones, Anterior; Propylthiouracil; Rats; Research; Thyroid Function Tests; Thyroid Gland; Thyrotropin; Thyrotropin-Releasing Hormone; Thyroxine; Toxicology

1965
Perchlorate affects thyroid function in eastern mosquitofish (Gambusia holbrooki) at environmentally relevant concentrations.
    Environmental science & technology, 2005, Jul-15, Volume: 39, Issue:14

    Topics: Animals; Biomarkers; Cyprinodontiformes; Dose-Response Relationship, Drug; Female; Perchlorates; Sensitivity and Specificity; Thyroid Gland; Thyroxine

2005
Evaluation of gene expression endpoints in the context of a Xenopus laevis metamorphosis-based bioassay to detect thyroid hormone disruptors.
    Aquatic toxicology (Amsterdam, Netherlands), 2006, Jan-05, Volume: 76, Issue:1

    Topics: Animals; Antithyroid Agents; Biological Assay; Brain; DNA-Binding Proteins; Fresh Water; Gene Expression Regulation, Developmental; Hindlimb; Larva; Metamorphosis, Biological; Methimazole; Perchlorates; Propylthiouracil; Random Allocation; Receptors, Thyroid Hormone; Reverse Transcriptase Polymerase Chain Reaction; Thyroid Hormones; Thyroxine; Time Factors; Transcription Factors; Triiodothyronine; Xenopus laevis; Xenopus Proteins

2006
The colloidal thyroxine (T4) ring as a novel biomarker of perchlorate exposure in the African clawed frog Xenopus laevis.
    Toxicological sciences : an official journal of the Society of Toxicology, 2006, Volume: 93, Issue:2

    Topics: Animals; Biomarkers; Colloids; Environmental Monitoring; Female; Growth; Immunohistochemistry; Male; Perchlorates; Thyroid Gland; Thyroxine; Water Pollutants, Chemical; Xenopus laevis

2006
Urinary perchlorate and thyroid hormone levels in adolescent and adult men and women living in the United States.
    Environmental health perspectives, 2006, Volume: 114, Issue:12

    Topics: Adolescent; Adult; Age Factors; Environmental Monitoring; Female; Humans; Logistic Models; Male; Perchlorates; Socioeconomic Factors; Thyroid Hormones; Thyrotropin; Thyroxine; United States

2006
Effects of larval-juvenile treatment with perchlorate and co-treatment with thyroxine on zebrafish sex ratios.
    General and comparative endocrinology, 2007, Volume: 150, Issue:3

    Topics: Age Factors; Analysis of Variance; Animals; Dose-Response Relationship, Drug; Drug Interactions; Environmental Pollutants; Female; Gonads; Larva; Male; Perchlorates; Sex Differentiation; Sex Ratio; Statistics, Nonparametric; Thyroid Gland; Thyroxine; Zebrafish

2007
Thyroid scintigraphy and perchlorate test after recombinant human TSH: a new tool for the differential diagnosis of congenital hypothyroidism during infancy.
    European journal of nuclear medicine and molecular imaging, 2007, Volume: 34, Issue:9

    Topics: Child; Child, Preschool; Congenital Hypothyroidism; Female; Humans; Infant; Iodides; Iodine Radioisotopes; Male; Perchlorates; Radionuclide Imaging; Recombinant Proteins; Thyroid Neoplasms; Thyrotropin; Thyroxine; Time Factors

2007
Impact of smoking and thiocyanate on perchlorate and thyroid hormone associations in the 2001-2002 national health and nutrition examination survey.
    Environmental health perspectives, 2007, Volume: 115, Issue:9

    Topics: Cotinine; Creatinine; Environmental Pollutants; Female; Humans; Iodine; Male; Nutrition Surveys; Perchlorates; Smoking; Thiocyanates; Thyrotropin; Thyroxine

2007
Gestational exposure to high perchlorate concentrations in drinking water and neonatal thyroxine levels.
    Thyroid : official journal of the American Thyroid Association, 2007, Volume: 17, Issue:9

    Topics: Adult; Blood Donors; Environmental Exposure; Female; Fetal Blood; Gestational Age; Humans; Infant, Newborn; Israel; Male; Perchlorates; Pregnancy; Thyroxine; Water Pollution, Chemical

2007
Developmental exposure to perchlorate alters synaptic transmission in hippocampus of the adult rat.
    Environmental health perspectives, 2008, Volume: 116, Issue:6

    Topics: Animals; Dose-Response Relationship, Drug; Female; Hippocampus; Male; Perchlorates; Pregnancy; Rats; Rats, Long-Evans; Synaptic Transmission; Thyroid Gland; Thyrotropin; Thyroxine; Triiodothyronine

2008
Urinary perchlorate excretion does not predict thyroid function among pregnant women.
    Thyroid : official journal of the American Thyroid Association, 2008, Volume: 18, Issue:7

    Topics: Chile; Female; Humans; Perchlorates; Predictive Value of Tests; Pregnancy; Regression Analysis; Thyroid Gland; Thyrotropin; Thyroxine

2008
Sortilin is a putative postendocytic receptor of thyroglobulin.
    Endocrinology, 2009, Volume: 150, Issue:1

    Topics: Adaptor Proteins, Vesicular Transport; Animals; Chlorocebus aethiops; COS Cells; Endocytosis; Female; Haplorhini; Methimazole; Mice; Mice, Inbred C57BL; Perchlorates; Rats; Thyroglobulin; Thyroid Gland; Thyroxine

2009
Thyroid histopathology assessments for the amphibian metamorphosis assay to detect thyroid-active substances.
    Toxicologic pathology, 2009, Volume: 37, Issue:4

    Topics: Animals; Atrophy; Biological Assay; Histocytochemistry; Hyperplasia; Hypertrophy; Larva; Metamorphosis, Biological; Perchlorates; Thyroid Gland; Thyroxine; Xenobiotics; Xenopus laevis

2009
Competitive inhibition of thyroidal uptake of dietary iodide by perchlorate does not describe perturbations in rat serum total T4 and TSH.
    Environmental health perspectives, 2009, Volume: 117, Issue:5

    Topics: Animals; Biological Transport; Iodides; Male; Perchlorates; Rats; Thyroid Gland; Thyrotropin; Thyroxine; Water Pollutants, Chemical

2009
The nature of the compensatory response to low thyroid hormone in the developing brain.
    Journal of neuroendocrinology, 2010, Volume: 22, Issue:3

    Topics: Animals; Antithyroid Agents; Brain; Female; Hypothyroidism; Iodide Peroxidase; Male; Methimazole; Monocarboxylic Acid Transporters; Neurogranin; Perchlorates; Propylthiouracil; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Thyrotropin; Thyroxine

2010
Oxidative stress: a required condition for thyroid cell proliferation.
    The American journal of pathology, 2010, Volume: 176, Issue:3

    Topics: Acetylcysteine; Animals; Cell Nucleus; Cell Proliferation; Cyclin D1; Female; Goiter; Organ Size; Oxidative Stress; Perchlorates; Peroxiredoxins; Proliferating Cell Nuclear Antigen; Propylthiouracil; Prostaglandin D2; Rats; Rats, Wistar; Thyroid Gland; Thyroxine

2010
Posttranscriptional regulation of sodium-iodide symporter mRNA expression in the rat thyroid gland by acute iodide administration.
    American journal of physiology. Cell physiology, 2010, Volume: 298, Issue:4

    Topics: Animals; Antithyroid Agents; Gene Expression Regulation; Iodides; Male; Methimazole; Perchlorates; Polyadenylation; Rats; Rats, Wistar; RNA, Messenger; Symporters; Thyroid Gland; Thyrotropin; Thyroxine; Triiodothyronine

2010
Perchlorate and thiocyanate exposure and thyroid function in first-trimester pregnant women.
    The Journal of clinical endocrinology and metabolism, 2010, Volume: 95, Issue:7

    Topics: Adult; Autoantibodies; Chromatography, Ion Exchange; Cross-Sectional Studies; Enzyme-Linked Immunosorbent Assay; Female; Health Surveys; Humans; Immunoassay; Iodine; Italy; Mass Spectrometry; Maternal Exposure; Maternal-Fetal Exchange; Perchlorates; Pregnancy; Pregnancy Trimester, First; Prospective Studies; Regression Analysis; Smoking; Thiocyanates; Thyroid Function Tests; Thyroid Gland; Thyrotropin; Thyroxine; Wales

2010
Inhibition of thyroid hormone release from cultured amphibian thyroid glands by methimazole, 6-propylthiouracil, and perchlorate.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:1

    Topics: Animals; Antithyroid Agents; Cattle; Coculture Techniques; Dose-Response Relationship, Drug; Female; Larva; Male; Methimazole; Organ Culture Techniques; Perchlorates; Pituitary Gland; Propylthiouracil; Thyroid Gland; Thyrotropin; Thyroxine; Xenopus laevis

2010
Modulation of thyroid hormone concentrations in serum of rats coadministered with perchlorate and iodide-deficient diet.
    Archives of environmental contamination and toxicology, 2011, Volume: 61, Issue:1

    Topics: Animals; Chromatography, Liquid; Environmental Pollutants; Iodides; Male; Perchlorates; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tandem Mass Spectrometry; Thyroxine

2011
Iodide treatment acutely increases pendrin (SLC26A4) mRNA expression in the rat thyroid and the PCCl3 thyroid cell line by transcriptional mechanisms.
    Molecular and cellular endocrinology, 2012, Mar-05, Volume: 350, Issue:1

    Topics: Animals; Antithyroid Agents; Cell Line; Cell Proliferation; Cell Survival; Chloride-Bicarbonate Antiporters; Dactinomycin; Iodides; Male; Methimazole; Perchlorates; Pituitary Gland; Protein Synthesis Inhibitors; Rats; Rats, Wistar; RNA, Messenger; Sulfate Transporters; Thyroid Gland; Thyrotropin; Thyroxine; Transcription, Genetic; Triiodothyronine

2012
Perchlorate and thiocyanate exposure and thyroid function in first-trimester pregnant women from Greece.
    Clinical endocrinology, 2012, Volume: 77, Issue:3

    Topics: Adult; Environmental Exposure; Female; Fetal Development; Greece; Humans; Iodides; Iodine; Perchlorates; Pregnancy; Pregnancy Trimester, First; Thiocyanates; Thyroid Function Tests; Thyroid Gland; Thyrotropin; Thyroxine; Triiodothyronine

2012
Environmental perchlorate and thiocyanate exposures and infant serum thyroid function.
    Thyroid : official journal of the American Thyroid Association, 2012, Volume: 22, Issue:9

    Topics: Adult; Boston; Breast Feeding; Cross-Sectional Studies; Environmental Exposure; Female; Humans; Infant; Iodine; Milk, Human; Perchlorates; Pregnancy; Prenatal Exposure Delayed Effects; Thiocyanates; Thyroid Function Tests; Thyroid Gland; Thyrotropin; Thyroxine; Young Adult

2012
Thyroid hormones and thyroid disease in relation to perchlorate dose and residence near a superfund site.
    Journal of exposure science & environmental epidemiology, 2013, Volume: 23, Issue:4

    Topics: Adult; California; Dose-Response Relationship, Drug; Drinking Water; Environmental Exposure; Female; Hazardous Waste Sites; Humans; Middle Aged; Perchlorates; Residence Characteristics; Thyroid Diseases; Thyroid Hormones; Thyrotropin; Thyroxine; Young Adult

2013
Regulation of gonadal sex ratios and pubertal development by the thyroid endocrine system in zebrafish (Danio rerio).
    General and comparative endocrinology, 2013, Apr-01, Volume: 184

    Topics: Animals; Antithyroid Agents; Endocrine System; Female; Gonads; Male; Methimazole; Ovary; Perchlorates; Puberty; Sex Ratio; Testis; Thyroxine; Zebrafish

2013
Dose-Response Relationship Between Orally Administered Ammonium Perchlorate and Urine Perchlorate Concentrations in Rats: Possible Biomarker to Quantify Environmental Ammonium Perchlorate Exposure on Thyroid Homeostasis.
    Archives of environmental & occupational health, 2015, Volume: 70, Issue:5

    Topics: Administration, Oral; Animals; Biomarkers; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Environmental Exposure; Homeostasis; Male; Mass Spectrometry; Perchlorates; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley; Thyroid Gland; Thyrotropin; Thyroxine; Triiodothyronine

2015
Iodine supplementation and drinking-water perchlorate mitigation.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2015, Volume: 80

    Topics: Dietary Supplements; Dose-Response Relationship, Drug; Drinking Water; Female; Fetus; Humans; Iodine; Models, Biological; Perchlorates; Pregnancy; Thyroxine

2015
Exogenous iodide ameliorates perchlorate-induced thyroid phenotypes in threespine stickleback.
    General and comparative endocrinology, 2017, 03-01, Volume: 243

    Topics: Animals; Iodides; Perchlorates; Phenotype; Sexual Maturation; Smegmamorpha; Thyroid Dysgenesis; Thyroid Epithelial Cells; Thyroid Gland; Thyroxine

2017
Evaluation of the risk of perchlorate exposure in a population of late-gestation pregnant women in the United States: Application of probabilistic biologically-based dose response modeling.
    Toxicology and applied pharmacology, 2017, 05-01, Volume: 322

    Topics: Adult; Drinking Water; Environmental Exposure; Female; Humans; Models, Statistical; Perchlorates; Pregnancy; Pregnancy Trimester, Third; Risk Assessment; Thyroxine; United States; Water Pollutants, Chemical; Water Supply

2017
Identifying Subpopulations Vulnerable to the Thyroid-Blocking Effects of Perchlorate and Thiocyanate.
    The Journal of clinical endocrinology and metabolism, 2017, 07-01, Volume: 102, Issue:7

    Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Child; Cross-Sectional Studies; Environmental Exposure; Female; Humans; Linear Models; Male; Middle Aged; Multivariate Analysis; Perchlorates; Retrospective Studies; Risk Assessment; Sex Factors; Thiocyanates; Thyroid Function Tests; Thyroid Gland; Thyrotropin; Thyroxine; Vulnerable Populations; Young Adult

2017
Environmental exposure to perchlorate, nitrate and thiocyanate, and thyroid function in Chinese adults: A community-based cross-sectional study.
    Environment international, 2023, Volume: 171

    Topics: Bayes Theorem; China; Cross-Sectional Studies; East Asian People; Environmental Exposure; Female; Humans; Iodine; Male; Middle Aged; Nitrates; Perchlorates; Thiocyanates; Thyroid Gland; Thyrotropin; Thyroxine; Triiodothyronine

2023
Towards translating in vitro measures of thyroid hormone system disruption to in vivo responses in the pregnant rat via a biologically based dose response (BBDR) model.
    Toxicology and applied pharmacology, 2023, Nov-15, Volume: 479

    Topics: Animals; Drinking Water; Female; Perchlorates; Pregnancy; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Thyroid Hormones; Thyrotropin; Thyroxine

2023