Page last updated: 2024-09-03

perchlorate and propylthiouracil

perchlorate has been researched along with propylthiouracil in 13 studies

Compound Research Comparison

Studies
(perchlorate)
Trials
(perchlorate)
Recent Studies (post-2010)
(perchlorate)
Studies
(propylthiouracil)
Trials
(propylthiouracil)
Recent Studies (post-2010) (propylthiouracil)
76833964,359120591

Protein Interaction Comparison

ProteinTaxonomyperchlorate (IC50)propylthiouracil (IC50)
MyeloperoxidaseHomo sapiens (human)2.81
Thyroid peroxidaseHomo sapiens (human)3.38

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19905 (38.46)18.7374
1990's0 (0.00)18.2507
2000's3 (23.08)29.6817
2010's5 (38.46)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
INGBAR, SH; RICHARDS, JB1
BLORSTAD, O; VOGT, JH1
SLINGERLAND, DW1
DOLGOVA, V; SERAFIMOV, N; SESTAKOV, G1
SCHOENBAUM, E; SELLERS, EA1
Degitz, SJ; Helbing, CC; Holcombe, GW; Kosian, PA; Tietge, J; Veldhoen, N; Zhang, F1
James-Walke, NL; McMillen, BA; Taylor, DA; Williams, HL1
Bailey, CM; Degitz, SJ; Gunderson, MP; Helbing, CC; Holcombe, GW; Ji, L; Korte, JJ; Kosian, PA; Lesperance, M; Mu, R; Skirrow, RC; Tietge, J; Veldhoen, N; Zhang, F1
Ferguson, DC; Gilbert, ME; Sharlin, DS; Taylor, MA; Zoeller, RT1
Colin, IM; GĂ©rard, AC; Humblet, K; Poncin, S; Van Eeckoudt, S1
Butterworth, BC; Degitz, SJ; Haselman, JT; Holcombe, GW; Hornung, MW; Korte, JJ; Kosian, PA; Tietge, JE; Wolfe, M1
Degitz, SJ; Hornung, MW; Korte, LM; Kosian, PA; Linnum, AL; Olson, JM; Tietge, JE1
Baumann, L; Braunbeck, T; Schmidt, F; Wolf, R1

Other Studies

13 other study(ies) available for perchlorate and propylthiouracil

ArticleYear
The effects of propylthiouracil and perchlorate on the biogenesis of thyroid hormone.
    Endocrinology, 1959, Volume: 65, Issue:2

    Topics: Chlorine; Hormones; Perchlorates; Propylthiouracil; Thiouracil; Thyroid Gland; Thyroid Hormones

1959
Combined treatment of thyrotoxicosis with perchlorate and propylthiouracil.
    Acta medica Scandinavica, 1962, Volume: 171

    Topics: Combined Modality Therapy; Hyperthyroidism; Manipulation, Osteopathic; Perchlorates; Propylthiouracil; Thiouracil; Thyrotoxicosis

1962
Effect of perchlorate on iodide in the thyroids of rats receiving propylthiouracil.
    Endocrinology, 1963, Volume: 73

    Topics: Animals; Iodides; Perchlorates; Propylthiouracil; Rats; Thyroid Gland

1963
[THYROID I-131 FIXATION AND PERCHLORATE LIBERATION IN HYPOTHERMIA IN DOGS TREATED WITH PROPYLTHIOURACIL].
    Godisen zbornik na Medicinskiot fakultet vo Skopje, 1963, Volume: 10

    Topics: Dogs; Hypothermia; Iodides; Iodine; Iodine Isotopes; Metabolism; Perchlorates; Pharmacology; Propylthiouracil; Radioisotopes; Research; Thyroid Gland

1963
FURTHER STUDIES ON THE GOITROGENIC ACTION OF THYROXINE ADMINISTERED WITH PROPYLTHIOURACIL, METHIMAZOLE OR PERCHLORATE.
    Acta endocrinologica, 1965, Volume: 49

    Topics: Antithyroid Agents; Body Weight; Iodine Isotopes; Methimazole; Organ Size; Perchlorates; Pharmacology; Pituitary Gland; Pituitary Hormones, Anterior; Propylthiouracil; Rats; Research; Thyroid Function Tests; Thyroid Gland; Thyrotropin; Thyrotropin-Releasing Hormone; Thyroxine; Toxicology

1965
Evaluation of gene expression endpoints in the context of a Xenopus laevis metamorphosis-based bioassay to detect thyroid hormone disruptors.
    Aquatic toxicology (Amsterdam, Netherlands), 2006, Jan-05, Volume: 76, Issue:1

    Topics: Animals; Antithyroid Agents; Biological Assay; Brain; DNA-Binding Proteins; Fresh Water; Gene Expression Regulation, Developmental; Hindlimb; Larva; Metamorphosis, Biological; Methimazole; Perchlorates; Propylthiouracil; Random Allocation; Receptors, Thyroid Hormone; Reverse Transcriptase Polymerase Chain Reaction; Thyroid Hormones; Thyroxine; Time Factors; Transcription Factors; Triiodothyronine; Xenopus laevis; Xenopus Proteins

2006
The effect of oral consumption of perchlorate, alone and in combination with ethanol, on plasma thyroid hormone and brain catecholamine concentrations in the rat.
    Basic & clinical pharmacology & toxicology, 2006, Volume: 99, Issue:5

    Topics: Alcohol-Induced Disorders, Nervous System; Animals; Animals, Outbred Strains; Brain; Brain Chemistry; Catecholamines; Chromatography, High Pressure Liquid; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combinations; Environmental Pollutants; Ethanol; Female; Perchlorates; Propylthiouracil; Rats; Thyroid Hormones

2006
Identification of gene expression indicators for thyroid axis disruption in a Xenopus laevis metamorphosis screening assay. Part 1. Effects on the brain.
    Aquatic toxicology (Amsterdam, Netherlands), 2007, May-31, Volume: 82, Issue:4

    Topics: Animals; Biomarkers; Brain; Environmental Monitoring; Gene Expression Regulation, Developmental; Larva; Methimazole; Oligonucleotide Array Sequence Analysis; Perchlorates; Propylthiouracil; Reverse Transcriptase Polymerase Chain Reaction; Thyroid Hormones; Time Factors; Water Pollutants, Chemical; Xenopus laevis

2007
The nature of the compensatory response to low thyroid hormone in the developing brain.
    Journal of neuroendocrinology, 2010, Volume: 22, Issue:3

    Topics: Animals; Antithyroid Agents; Brain; Female; Hypothyroidism; Iodide Peroxidase; Male; Methimazole; Monocarboxylic Acid Transporters; Neurogranin; Perchlorates; Propylthiouracil; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Thyrotropin; Thyroxine

2010
Oxidative stress: a required condition for thyroid cell proliferation.
    The American journal of pathology, 2010, Volume: 176, Issue:3

    Topics: Acetylcysteine; Animals; Cell Nucleus; Cell Proliferation; Cyclin D1; Female; Goiter; Organ Size; Oxidative Stress; Perchlorates; Peroxiredoxins; Proliferating Cell Nuclear Antigen; Propylthiouracil; Prostaglandin D2; Rats; Rats, Wistar; Thyroid Gland; Thyroxine

2010
Early temporal effects of three thyroid hormone synthesis inhibitors in Xenopus laevis.
    Aquatic toxicology (Amsterdam, Netherlands), 2010, Jun-01, Volume: 98, Issue:1

    Topics: Animals; Antithyroid Agents; Cell Count; Larva; Methimazole; Perchlorates; Propylthiouracil; Thyroid Gland; Thyroid Hormones; Xenopus laevis

2010
Inhibition of thyroid hormone release from cultured amphibian thyroid glands by methimazole, 6-propylthiouracil, and perchlorate.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:1

    Topics: Animals; Antithyroid Agents; Cattle; Coculture Techniques; Dose-Response Relationship, Drug; Female; Larva; Male; Methimazole; Organ Culture Techniques; Perchlorates; Pituitary Gland; Propylthiouracil; Thyroid Gland; Thyrotropin; Thyroxine; Xenopus laevis

2010
Ultrastructural Alterations in Thyrocytes of Zebrafish ( Danio rerio) after Exposure to Propylthiouracil and Perchlorate.
    Toxicologic pathology, 2017, Volume: 45, Issue:5

    Topics: Animals; Perchlorates; Propylthiouracil; Thyroid Epithelial Cells; Thyroid Gland; Water Pollutants, Chemical; Zebrafish

2017