Compounds > peptide elongation factor 2
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peptide elongation factor 2 and guanosine triphosphate

peptide elongation factor 2 has been researched along with guanosine triphosphate in 58 studies

Research

Studies (58)

TimeframeStudies, this research(%)All Research%
pre-199018 (31.03)18.7374
1990's25 (43.10)18.2507
2000's7 (12.07)29.6817
2010's6 (10.34)24.3611
2020's2 (3.45)2.80

Authors

AuthorsStudies
Guillot, D; Lavergne, JP; Reboud, AM; Reboud, JP; Sontag, B1
Nilsson, L; Nygård, O10
Endo, Y; Furutani, M; Igarashi, K; Ito, K; Kashiwagi, K1
Ryazanov, AG; Spirin, AS1
Davydova, EK; Ovchinnikov, LP1
Lavergne, JP; Marzouki, A; Reboud, AM; Reboud, JP2
Carlberg, U; Nilsson, A; Nygård, O1
Davydova, EK; Ryazanov, AG1
Bermek, E; Nurten, R; Ozdemirli, M; Sayhan, O1
Conquet, F; Lavergne, JP; Reboud, AM; Reboud, JP1
Nilsson, L; Nygård, O; Westermann, P1
Nairn, AC; Palfrey, HC1
Asano, K; Nilsson, L; Nygård, O; Poulsen, FM; Svensson, B1
Abraham, AK; Burns, G; Vedeler, A1
Iwasaki, K; Kikuchi, M; Ogata, K; Terao, K; Uchiumi, T1
Bermek, E; Nurten, R1
Aktar, NB; Bermek, E; Nurten, R1
Creppy, EE; Dirheimer, G; Ennamany, R; Lavergne, JP; Reboud, JP1
Gonzalo, P; Guillot, D; Reboud, JP; Sontag, B1
Dumont-Miscopein, A; Guillot, D; Lavergne, JP; Reboud, JP; Sontag, B1
Holmberg, L; Nygård, O1
Guillot, D; Lavergne, JP; Reboud, JP1
Amatruda, MR; Bocchini, V; De Vendittis, E; Masullo, M1
Davydova, EK; Malinin, NL; Ovchinnikov, LP1
Di Pietro, A; Guillot, D; Lavergne, JP; Penin, F; Reboud, JP; Sontag, B1
Di Pietro, A; Divita, G; Guillot, D; Reboud, AM; Reboud, JP; Sontag, B1
Guillot, D; Reboud, JP; Vard, C1
Bodley, JW; Rao, S1
Bocchini, V; Masullo, M; Raimo, G; Scarano, G1
Fabrizio, P; Laggerbauer, B; Lane, WS; Lauber, J; Lührmann, R1
Marshall, CJ; Mittnacht, S; Olson, MF; Paterson, H1
Buckingham, RH; Ehrenberg, M; Grentzmann, G; Heurgué-Hamard, V; Karimi, R; Leboeuf, C; MacDougall, J; Mora, L1
Domínguez, JM; Gómez-Lorenzo, MG; Martín, JJ1
Cavicchioli, R; Thomas, T1
Ahuja, D; Joullié, MM; Morimoto, H; SirDeshpande, BV; Toogood, PL; Vera, MD; Williams, PG1
Gonzalo, P; Jault, JM; Lavergne, JP; Reboud, JP; Sontag, B1
Armstrong, S; Merrill, AR; Yates, SP1
Andersen, GR; Frank, J; Merrill, AR; Nilsson, J; Nissen, P; Taylor, DJ1
Demeshkina, N; Hirokawa, G; Kaji, A; Kaji, H1
Frank, J; Gursky, R; Kjeldgaard, M; Nilsson, J; Nissen, P; Sengupta, J1
Kaul, G; Pattan, G; Rafeequi, T1
Abeyrathne, PD; Grant, T; Grigorieff, N; Koh, CS; Korostelev, AA1
Alkalaeva, E; Egorova, T; Ivanov, A; Shatsky, IN; Shuvalov, A; Shuvalova, E; Susorov, D; Zakharov, N1
Girodat, D; Kato, K; Kumakura, Y; Ose, T; Tanaka, I; Tanzawa, T; Uchiumi, T; Wieden, HJ; Yao, M1
Demeshkina, N; Hashem, Y; Mancera-Martinez, E; Melnikov, S; Myasnikov, A; Pellegrino, S; Simonetti, A; Yusupov, M; Yusupova, G1
Blanchard, SC; Budkevich, TV; Bürger, J; Dabrowski, M; Flis, J; Hilal, T; Holm, M; Loerke, J; Mielke, T; Rundlet, EJ; Spahn, CMT1
Miyoshi, T; Nomura, T; Takeya, K; Uchiumi, T1
Ou, Z; Petrov, A1

Reviews

2 review(s) available for peptide elongation factor 2 and guanosine triphosphate

ArticleYear
Phosphorylation of elongation factor 2: a key mechanism regulating gene expression in vertebrates.
    The New biologist, 1990, Volume: 2, Issue:10

    Topics: Adrenal Gland Neoplasms; Amino Acid Sequence; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Elongation Factor 2 Kinase; Globins; Guanosine Triphosphate; Interphase; Mitosis; Molecular Sequence Data; Nerve Growth Factors; Oogenesis; Peptide Chain Elongation, Translational; Peptide Elongation Factor 2; Peptide Elongation Factors; Pheochromocytoma; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinases; Protein Processing, Post-Translational; Rabbits; Sequence Homology, Nucleic Acid; Signal Transduction; Transcription, Genetic; Tumor Cells, Cultured; Vertebrates; Xenopus laevis

1990
Eukaryotic elongation factor-2 (eEF2): its regulation and peptide chain elongation.
    Cell biochemistry and function, 2011, Volume: 29, Issue:3

    Topics: Animals; Calcium; Calmodulin; Cattle; Elongation Factor 2 Kinase; Eukaryota; Female; Gene Expression Regulation; Guanosine Triphosphate; Humans; Lactation; Milk Proteins; Mitogen-Activated Protein Kinases; Peptide Elongation Factor 2; Phosphorylation; Protein Biosynthesis; Ribosomes; RNA, Messenger; Signal Transduction; Synthetic Biology; TOR Serine-Threonine Kinases

2011

Other Studies

56 other study(ies) available for peptide elongation factor 2 and guanosine triphosphate

ArticleYear
Binding of GDP to a ribosomal protein after elongation factor-2 dependent GTP hydrolysis.
    Biochimica et biophysica acta, 1992, Oct-20, Volume: 1132, Issue:3

    Topics: Amino Acid Sequence; Animals; Electrophoresis, Gel, Two-Dimensional; Guanosine Diphosphate; Guanosine Triphosphate; Hydrolysis; In Vitro Techniques; Molecular Sequence Data; Peptide Elongation Factor 2; Peptide Elongation Factors; Rats; Ribosomal Proteins; Ribosomes; RNA, Transfer, Phe

1992
Reduced puromycin sensitivity of translocated polysomes after the addition of elongation factor 2 and non-hydrolysable GTP analogues.
    FEBS letters, 1992, Aug-31, Volume: 309, Issue:1

    Topics: Animals; Guanosine Triphosphate; Kinetics; Models, Biological; Peptide Elongation Factor 2; Peptide Elongation Factors; Polyribosomes; Puromycin; Rabbits; Reticulocytes

1992
Comparison of the modes of action of a Vero toxin (a Shiga-like toxin) from Escherichia coli, of ricin, and of alpha-sarcin.
    Archives of biochemistry and biophysics, 1992, Feb-14, Volume: 293, Issue:1

    Topics: Animals; Bacterial Toxins; Endoribonucleases; Fungal Proteins; Globins; Guanosine Triphosphate; In Vitro Techniques; Peptide Chain Elongation, Translational; Peptide Elongation Factor 1; Peptide Elongation Factor 2; Peptide Elongation Factors; Protein Biosynthesis; Rabbits; Ribosomes; Ricin; RNA, Transfer, Amino Acyl; Shiga Toxin 1

1992
ADP-ribosylated elongation factor 2 (ADP-ribosyl-EF-2) is unable to promote translocation within the ribosome.
    FEBS letters, 1990, Feb-26, Volume: 261, Issue:2

    Topics: Adenosine Diphosphate Ribose; Animals; Binding, Competitive; Biological Transport; Diphtheria Toxin; Guanosine Triphosphate; Peptide Elongation Factor 2; Peptide Elongation Factors; Poly U; Puromycin; Rabbits; Ribosomes; RNA, Transfer, Phe

1990
Kinetic determination of the effects of ADP-ribosylation on the interaction of eukaryotic elongation factor 2 with ribosomes.
    The Journal of biological chemistry, 1990, Apr-15, Volume: 265, Issue:11

    Topics: Adenosine Diphosphate Ribose; Animals; Carcinoma, Ehrlich Tumor; Diphtheria Toxin; Guanosine Triphosphate; Kinetics; Mice; NAD; Peptide Elongation Factor 2; Peptide Elongation Factors; Phosphoproteins; Ribosomes; Ricin

1990
Modification of the reactivity of three amino-acid residues in elongation factor 2 during its binding to ribosomes and translocation.
    Biochimica et biophysica acta, 1990, Apr-06, Volume: 1048, Issue:2-3

    Topics: Adenosine Diphosphate Ribose; Animals; Guanine Nucleotides; Guanosine Diphosphate; Guanosine Triphosphate; Liver; Mutation; NAD; Peptide Elongation Factor 2; Peptide Elongation Factors; Peptide Mapping; Phosphoproteins; Phosphorylation; Protein Binding; Rats; Ribosomes; Trypsin

1990
Modification of the accessibility of ribosomal proteins after elongation factor 2 binding to rat liver ribosomes and during translocation.
    Biochimica et biophysica acta, 1990, Apr-06, Volume: 1048, Issue:2-3

    Topics: Animals; Electrophoresis, Gel, Two-Dimensional; Guanosine Diphosphate; Guanosine Triphosphate; Liver; Models, Biological; Peptide Elongation Factor 2; Peptide Elongation Factors; Phosphoproteins; Protein Binding; Rats; Ribosomal Proteins; Ribosomes; Trypsin

1990
Functional properties of phosphorylated elongation factor 2.
    European journal of biochemistry, 1990, Aug-17, Volume: 191, Issue:3

    Topics: Animals; Catalysis; Electrophoresis, Gel, Two-Dimensional; Guanosine Triphosphate; Hydrolysis; Kinetics; NAD; Peptide Elongation Factor 2; Peptide Elongation Factors; Phosphoproteins; Phosphorylation; Protein Biosynthesis; Rabbits; Rats; Rats, Inbred Strains; Reticulocytes; Ribosomes

1990
Characterization of the ribosomal properties required for formation of a GTPase active complex with the eukaryotic elongation factor 2.
    European journal of biochemistry, 1989, Feb-15, Volume: 179, Issue:3

    Topics: Animals; Binding Sites; GTP Phosphohydrolase-Linked Elongation Factors; Guanosine Triphosphate; Hydrolysis; Kinetics; Peptide Elongation Factor 2; Peptide Elongation Factors; Phosphoric Monoester Hydrolases; Rats; Ribosomal Proteins; Ribosomes

1989
Mechanism of elongation factor 2 (EF-2) inactivation upon phosphorylation. Phosphorylated EF-2 is unable to catalyze translocation.
    FEBS letters, 1989, Jul-17, Volume: 251, Issue:1-2

    Topics: Animals; Calcium; Calmodulin; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Peptide Elongation Factor 2; Peptide Elongation Factors; Phosphorylation; Poly U; Protein Kinases; Puromycin; Rabbits; Ribosomes; RNA, Transfer, Phe; Structure-Activity Relationship

1989
On the nature of cellular ADP-ribosyltransferase from rat liver specific for elongation factor 2.
    Biochemical and biophysical research communications, 1986, Sep-30, Volume: 139, Issue:3

    Topics: Adenosine Diphosphate Ribose; ADP Ribose Transferases; Animals; Diphtheria Toxin; Electrophoresis, Polyacrylamide Gel; Guanosine Triphosphate; Kinetics; Liver; Pentosyltransferases; Peptide Elongation Factor 2; Peptide Elongation Factors; Rats

1986
Structural and functional studies of the interaction of the eukaryotic elongation factor EF-2 with GTP and ribosomes.
    European journal of biochemistry, 1988, Jan-15, Volume: 171, Issue:1-2

    Topics: Affinity Labels; Animals; Binding Sites; Guanosine Triphosphate; Kinetics; Peptide Elongation Factor 2; Peptide Elongation Factors; Peptide Fragments; Protein Binding; Rats; Ribosomes; Structure-Activity Relationship; Trypsin

1988
Role of acidic phosphoproteins in the partial reconstitution of the active 60 S ribosomal subunit.
    FEBS letters, 1987, May-25, Volume: 216, Issue:1

    Topics: Animals; Guanosine Triphosphate; Liver; Maleic Anhydrides; Peptide Elongation Factor 2; Peptide Elongation Factors; Phosphoproteins; Phosphorylation; Protein Biosynthesis; Rats; Ribosomal Proteins; Ribosomes

1987
Characterisation of the ribosomal binding site for eukaryotic elongation factor 2 by chemical cross-linking.
    Biochimica et biophysica acta, 1987, Dec-08, Volume: 910, Issue:3

    Topics: Animals; Binding Sites; Cross-Linking Reagents; Electrophoresis, Polyacrylamide Gel; Guanosine Triphosphate; Peptide Elongation Factor 2; Peptide Elongation Factors; Rats; Ribosomal Proteins; Ribosomes

1987
Identification of the major Mr 100,000 substrate for calmodulin-dependent protein kinase III in mammalian cells as elongation factor-2.
    The Journal of biological chemistry, 1987, Dec-25, Volume: 262, Issue:36

    Topics: Adenosine Diphosphate Ribose; Amino Acid Sequence; Amino Acids; Animals; Calmodulin; Guanosine Triphosphate; Molecular Weight; Peptide Elongation Factor 2; Peptide Elongation Factors; Peptide Mapping; Phosphorylation; Protein Kinases; Rats

1987
Reduced turnover of the elongation factor EF-1 X ribosome complex after treatment with the protein synthesis inhibitor II from barley seeds.
    Biochimica et biophysica acta, 1986, Oct-16, Volume: 868, Issue:1

    Topics: Animals; GTP Phosphohydrolase-Linked Elongation Factors; Guanosine Triphosphate; Hordeum; Macromolecular Substances; Peptide Chain Elongation, Translational; Peptide Elongation Factor 1; Peptide Elongation Factor 2; Peptide Elongation Factors; Peptidyl Transferases; Plant Extracts; Plant Lectins; Rabbits; Rats; Reticulocytes; Ribosomes; Ricin; Seeds

1986
The mechanism of the protein-synthesis elongation cycle in eukaryotes. Effect of ricin on the ribosomal interaction with elongation factors.
    European journal of biochemistry, 1986, Nov-17, Volume: 161, Issue:1

    Topics: Animals; Binding Sites; GTP Phosphohydrolase-Linked Elongation Factors; Guanosine Triphosphate; Hydrolysis; Peptide Chain Elongation, Translational; Peptide Elongation Factor 1; Peptide Elongation Factor 2; Peptide Elongation Factors; Protein Biosynthesis; Rats; Reticulocytes; Ribosomes; Ricin

1986
Nucleotide binding to elongation factor 2 inactivated by diphtheria toxin.
    FEBS letters, 1986, Nov-24, Volume: 208, Issue:2

    Topics: Adenosine Diphosphate Ribose; Diphtheria Toxin; Guanine Nucleotides; Guanosine Triphosphate; In Vitro Techniques; Peptide Elongation Factor 2; Peptide Elongation Factors; Ribosomes; Triticum

1986
The ribosomal binding site for eukaryotic elongation factor EF-2 contains 5 S ribosomal RNA.
    Biochimica et biophysica acta, 1987, Jan-28, Volume: 908, Issue:1

    Topics: Animals; Binding Sites; Cross-Linking Reagents; Guanosine Triphosphate; Liver; Peptide Elongation Factor 2; Peptide Elongation Factors; Rats; Ribosomal Proteins; Ribosomes; RNA, Ribosomal

1987
Cross-linking of elongation factor 2 to rat-liver ribosomal proteins by 2-iminothiolane.
    European journal of biochemistry, 1986, Apr-01, Volume: 156, Issue:1

    Topics: Animals; Binding Sites; Carboxymethylcellulose Sodium; Chromatography; Cross-Linking Reagents; Electrophoresis, Polyacrylamide Gel; Guanosine Triphosphate; Imidoesters; Liver; Peptide Elongation Factor 2; Peptide Elongation Factors; Protein Binding; Rats; Ribosomal Proteins; Swine

1986
Reduced ribosomal binding of eukaryotic elongation factor 2 following ADP-ribosylation. Difference in binding selectivity between polyribosomes and reconstituted monoribosomes.
    Biochimica et biophysica acta, 1985, Feb-20, Volume: 824, Issue:2

    Topics: Adenosine Diphosphate Ribose; Animals; Diphtheria Toxin; Guanosine Diphosphate; Guanosine Triphosphate; NAD; Nucleoside Diphosphate Sugars; Peptide Elongation Factor 2; Peptide Elongation Factors; Protein Binding; Rabbits; Rats; Ribosomes; Structure-Activity Relationship

1985
Localization of the sites of ADP-ribosylation and GTP binding in the eukaryotic elongation factor EF-2.
    European journal of biochemistry, 1985, Apr-15, Volume: 148, Issue:2

    Topics: Adenosine Diphosphate Ribose; Affinity Labels; Binding Sites; Chymotrypsin; Guanosine Triphosphate; Hydrolysis; Nucleoside Diphosphate Sugars; Peptide Elongation Factor 2; Peptide Elongation Factors; Peptide Fragments; Structure-Activity Relationship; Succinimides; Trypsin

1985
Interactions of elongation factor 2 (EF-2) with guanine nucleotides and ribosomes. Binding of periodate-oxidized guanine nucleotides to EF-2.
    European journal of biochemistry, 1980, Volume: 103, Issue:3

    Topics: Animals; Guanine Nucleotides; Guanosine Diphosphate; Guanosine Triphosphate; Kinetics; Liver; Oxidation-Reduction; Peptide Elongation Factor 2; Peptide Elongation Factors; Periodic Acid; Rats; Ribosomes

1980
Nucleotide-mediated interactions of eukaryotic elongation factor EF-2 with ribosomes.
    European journal of biochemistry, 1984, Apr-02, Volume: 140, Issue:1

    Topics: Animals; Binding Sites; Centrifugation, Density Gradient; Electrophoresis, Polyacrylamide Gel; Guanine Nucleotides; Guanosine Triphosphate; Microsomes, Liver; Peptide Elongation Factor 2; Peptide Elongation Factors; Rats; Ribosomes

1984
Affinity labelling of the eukaryotic elongation factor EF-2 with the guanosine nucleotide analogue 5'-p-fluorosulfonylbenzoylguanosine.
    Biochimica et biophysica acta, 1984, May-15, Volume: 782, Issue:1

    Topics: Affinity Labels; Animals; Binding, Competitive; Guanosine; Guanosine Triphosphate; Magnesium; Microsomes, Liver; Peptide Elongation Factor 2; Peptide Elongation Factors; Protein Binding; Rats; Ribosomes

1984
Functional groups of elongation factor 2 involved in interactions with guanosine nucleotides and ribosomes.
    FEBS letters, 1983, Apr-18, Volume: 154, Issue:2

    Topics: Adenosine Diphosphate Ribose; Ethylmaleimide; Guanine Nucleotides; Guanosine Triphosphate; Peptide Elongation Factor 2; Peptide Elongation Factors; Ribosomes; Trinitrobenzenesulfonic Acid

1983
Mode of action of bolesatine, a cytotoxic glycoprotein from Boletus satanas Lenz. Mechanistic approaches.
    Toxicology, 1995, Jun-26, Volume: 100, Issue:1-3

    Topics: Adenosine Triphosphate; Animals; Basidiomycota; Fungal Proteins; Guanosine Triphosphate; Hydrolysis; In Vitro Techniques; Liver; Mycotoxins; Nerve Tissue Proteins; Peptide Elongation Factor 2; Peptide Elongation Factors; Phenylalanine; Poly U; Protein Synthesis Inhibitors; Rats; Ribosomes

1995
Fluorometric assay of GTPase activity: application to the couple elongation factor eEF-2-ribosome.
    Analytical biochemistry, 1995, Feb-10, Volume: 225, Issue:1

    Topics: GTP Phosphohydrolase-Linked Elongation Factors; Guanosine Triphosphate; Kinetics; Peptide Elongation Factor 2; Peptide Elongation Factors; Phosphorus Radioisotopes; Radioisotope Dilution Technique; Ribosomes; Sensitivity and Specificity; Spectrometry, Fluorescence; Time Factors

1995
Interaction of phosphorylated elongation factor EF-2 with nucleotides and ribosomes.
    FEBS letters, 1994, Dec-19, Volume: 356, Issue:2-3

    Topics: Adenosine Triphosphate; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Guanosine Diphosphate; Guanosine Triphosphate; Isoelectric Focusing; Kinetics; Liver; Nucleotides; Peptide Elongation Factor 2; Peptide Elongation Factors; Phosphoproteins; Phosphorylation; Rats; Ribosomes; Spectrometry, Fluorescence

1994
Interaction sites of ribosome-bound eukaryotic elongation factor 2 in 18S and 28S rRNA.
    Biochemistry, 1994, Dec-20, Volume: 33, Issue:50

    Topics: Animals; Base Sequence; Binding Sites; Carcinoma, Ehrlich Tumor; CME-Carbodiimide; Cross-Linking Reagents; Guanosine Triphosphate; Mice; Micrococcal Nuclease; Molecular Sequence Data; Nucleic Acid Conformation; Peptide Elongation Factor 2; Peptide Elongation Factors; Ribosomes; RNA, Ribosomal, 18S; RNA, Ribosomal, 28S; Sulfuric Acid Esters

1994
Trp221 is involved in the protective effect of elongation factor eEF-2 on the ricin/alpha-sarcin site of the ribosome.
    The Journal of biological chemistry, 1993, Dec-15, Volume: 268, Issue:35

    Topics: Animals; Binding Sites; Endoribonucleases; Fungal Proteins; Guanosine Triphosphate; Oxidation-Reduction; Peptide Elongation Factor 2; Peptide Elongation Factors; Rats; Ricin; RNA, Ribosomal, 28S; Tryptophan

1993
Cloning and sequencing of the gene encoding thermostable elongation factor 2 in Sulfolobus solfataricus.
    Gene, 1993, Dec-22, Volume: 136, Issue:1-2

    Topics: Amino Acid Sequence; Base Sequence; Binding Sites; Cloning, Molecular; Codon; DNA, Bacterial; Genes, Bacterial; Guanosine Triphosphate; Hot Temperature; Molecular Sequence Data; Peptide Elongation Factor 2; Peptide Elongation Factors; Regulatory Sequences, Nucleic Acid; Sequence Homology, Amino Acid; Sulfolobus

1993
Ribosomes terminated in vitro are in a tight association with non-phosphorylated elongation factor 2 (eEF-2) and GDP.
    European journal of biochemistry, 1993, Jul-15, Volume: 215, Issue:2

    Topics: Animals; Cell-Free System; Electrophoresis, Gel, Two-Dimensional; Guanosine Diphosphate; Guanosine Triphosphate; Peptide Chain Termination, Translational; Peptide Elongation Factor 2; Peptide Elongation Factors; Phosphorylation; Protein Biosynthesis; Rabbits; Reticulocytes; Ribosomes

1993
GTP binding to elongation factor eEF-2 unmasks a tryptophan residue required for biological activity.
    The Journal of biological chemistry, 1993, Oct-05, Volume: 268, Issue:28

    Topics: Amino Acid Sequence; Animals; Bromosuccinimide; Guanosine Diphosphate; Guanosine Triphosphate; Humans; Liver; Molecular Sequence Data; Oxidation-Reduction; Peptide Elongation Factor 2; Peptide Elongation Factors; Rats; Sequence Homology, Amino Acid; Spectrometry, Fluorescence; Tryptophan

1993
Intrinsic tryptophan fluorescence of rat liver elongation factor eEF-2 to monitor the interaction with guanylic and adenylic nucleotides and related conformational changes.
    Biochemistry, 1993, Mar-02, Volume: 32, Issue:8

    Topics: Adenine Nucleotides; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Guanine Nucleotides; Guanosine Diphosphate; Guanosine Triphosphate; Kinetics; Mathematics; Peptide Elongation Factor 2; Peptide Elongation Factors; Protein Conformation; Rats; Spectrometry, Fluorescence; Tryptophan

1993
Photoaffinity labeling of elongation factor-2 with 8-azido derivatives of GTP and ATP.
    European journal of biochemistry, 1996, Feb-15, Volume: 236, Issue:1

    Topics: Adenosine Triphosphate; Affinity Labels; Amino Acid Sequence; Azides; Binding Sites; Binding, Competitive; Guanosine Triphosphate; Light; Molecular Sequence Data; Peptide Elongation Factor 2; Peptide Elongation Factors; Peptide Fragments

1996
Expression, purification, and characterization of the G domain of Saccharomyces cerevisiae elongation factor 2.
    Protein expression and purification, 1996, Volume: 8, Issue:1

    Topics: Cloning, Molecular; DNA Primers; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Gene Expression; GTP-Binding Proteins; Guanosine Diphosphate; Guanosine Triphosphate; Isopropyl Thiogalactoside; Peptide Elongation Factor 2; Peptide Elongation Factors; Polymerase Chain Reaction; Protein Biosynthesis; Protein Denaturation; Recombinant Proteins; Ribosomes; Saccharomyces cerevisiae

1996
The site for GTP hydrolysis on the archaeal elongation factor 2 is unmasked by aliphatic alcohols.
    Biochimie, 1996, Volume: 78, Issue:10

    Topics: Adenosine Diphosphate Ribose; Alcohols; Barium Compounds; Binding Sites; Cations, Divalent; Chlorides; Ethylene Glycol; Ethylene Glycols; GTP Phosphohydrolase-Linked Elongation Factors; GTP-Binding Proteins; Guanosine Diphosphate; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Hydrogen-Ion Concentration; Hydrolysis; Peptide Elongation Factor 2; Peptide Elongation Factors; Sulfolobus; Temperature

1996
An evolutionarily conserved U5 snRNP-specific protein is a GTP-binding factor closely related to the ribosomal translocase EF-2.
    The EMBO journal, 1997, Jul-01, Volume: 16, Issue:13

    Topics: Amino Acid Sequence; Animals; Base Sequence; Caenorhabditis elegans; Cell Survival; Conserved Sequence; Cross-Linking Reagents; DNA, Complementary; Evolution, Molecular; Genes, Lethal; GTP-Binding Proteins; Guanosine Triphosphate; HeLa Cells; Humans; Mice; Molecular Sequence Data; Mutagenesis; Peptide Elongation Factor 2; Peptide Elongation Factor G; Peptide Elongation Factors; Phenotype; Ribonucleoprotein, U5 Small Nuclear; RNA Precursors; RNA Splicing; Subcellular Fractions; Ultraviolet Rays

1997
Ras signalling is required for inactivation of the tumour suppressor pRb cell-cycle control protein.
    Current biology : CB, 1997, Mar-01, Volume: 7, Issue:3

    Topics: Animals; Antibodies, Monoclonal; Carrier Proteins; Cell Cycle; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p16; DNA Replication; Enzyme Activation; Fibroblasts; Guanosine Triphosphate; Humans; Immunoglobulin G; Mice; Mice, Knockout; Peptide Elongation Factor 2; Peptide Elongation Factors; Proto-Oncogene Proteins p21(ras); Rats; Retinoblastoma Protein; Signal Transduction; Tumor Cells, Cultured

1997
Ribosome release factor RF4 and termination factor RF3 are involved in dissociation of peptidyl-tRNA from the ribosome.
    The EMBO journal, 1998, Feb-02, Volume: 17, Issue:3

    Topics: Bacterial Proteins; Carboxylic Ester Hydrolases; Culture Media; DNA Transposable Elements; Escherichia coli; Gene Expression Regulation, Bacterial; Genes, Bacterial; Guanosine Triphosphate; Mutation; Peptide Chain Termination, Translational; Peptide Elongation Factor 2; Peptide Elongation Factors; Peptide Termination Factors; Proteins; Ribosomal Proteins; Ribosomes; RNA, Transfer, Amino Acyl; Suppression, Genetic; Temperature

1998
Sordarin inhibits fungal protein synthesis by blocking translocation differently to fusidic acid.
    The Journal of biological chemistry, 1999, Aug-06, Volume: 274, Issue:32

    Topics: Antifungal Agents; Candida albicans; Dose-Response Relationship, Drug; Fusidic Acid; GTP Phosphohydrolase-Linked Elongation Factors; Guanosine Triphosphate; Hydrolysis; Indenes; Models, Biological; Peptide Chain Elongation, Translational; Peptide Elongation Factor 2; Peptide Elongation Factors; Protein Synthesis Inhibitors; Puromycin; Ribosomes; Ricin

1999
Effect of temperature on stability and activity of elongation factor 2 proteins from Antarctic and thermophilic methanogens.
    Journal of bacteriology, 2000, Volume: 182, Issue:5

    Topics: Alcohols; Cations; Escherichia coli; Gene Expression Regulation, Bacterial; Guanosine Diphosphate; Guanosine Triphosphate; Hydrolysis; Methanosarcina; Methanosarcinaceae; Peptide Elongation Factor 2; Protein Folding; Recombinant Fusion Proteins; Temperature

2000
Inhibition of protein synthesis by didemnin B: how EF-1alpha mediates inhibition of translocation.
    Biochemistry, 2000, Apr-18, Volume: 39, Issue:15

    Topics: Animals; Antineoplastic Agents; Depsipeptides; Diphtheria Toxin; Fusidic Acid; Guanosine Diphosphate; Guanosine Triphosphate; Hydrolysis; Inhibitory Concentration 50; Models, Biological; Peptide Elongation Factor 1; Peptide Elongation Factor 2; Peptides, Cyclic; Potassium Chloride; Protein Binding; Protein Biosynthesis; Protein Synthesis Inhibitors; Rabbits; Ribosomes; Solutions; Thermodynamics

2000
Evidence for a second nucleotide binding site in rat elongation factor eEF-2 specific for adenylic nucleotides.
    Biochemistry, 2000, Nov-07, Volume: 39, Issue:44

    Topics: Adenine Nucleotides; Adenosine Diphosphate; Adenosine Triphosphate; Affinity Labels; Amino Acid Sequence; Animals; Binding, Competitive; Chickens; Cricetinae; Cricetulus; Energy Transfer; Fluorescent Dyes; Guanosine Diphosphate; Guanosine Triphosphate; Humans; Molecular Sequence Data; ortho-Aminobenzoates; Peptide Elongation Factor 2; Protein Binding; Rats; Spectrometry, Fluorescence

2000
Insight into the catalytic mechanism of Pseudomonas aeruginosa exotoxin A. Studies of toxin interaction with eukaryotic elongation factor-2.
    The Journal of biological chemistry, 2002, Nov-29, Volume: 277, Issue:48

    Topics: ADP Ribose Transferases; Bacterial Toxins; Catalysis; Catalytic Domain; Energy Transfer; Exotoxins; Fluorescence; Guanosine Diphosphate; Guanosine Triphosphate; Mutagenesis, Site-Directed; NAD; Peptide Elongation Factor 2; Protein Binding; Pseudomonas aeruginosa Exotoxin A; Virulence Factors

2002
Structures of modified eEF2 80S ribosome complexes reveal the role of GTP hydrolysis in translocation.
    The EMBO journal, 2007, May-02, Volume: 26, Issue:9

    Topics: Adenosine Diphosphate; Ascomycota; Cryoelectron Microscopy; Guanosine Triphosphate; Hydrolysis; Models, Molecular; Molecular Sequence Data; Peptide Elongation Factor 2; Peptide Elongation Factor G; Protein Structure, Tertiary; Ribosomes; RNA Transport; RNA, Messenger; RNA, Transfer

2007
Novel activity of eukaryotic translocase, eEF2: dissociation of the 80S ribosome into subunits with ATP but not with GTP.
    Nucleic acids research, 2007, Volume: 35, Issue:14

    Topics: Adenosine Triphosphate; Centrifugation, Density Gradient; Guanosine Triphosphate; Light; Peptide Elongation Factor 2; Peptide Initiation Factors; Ribosomes; Scattering, Radiation

2007
Visualization of the eEF2-80S ribosome transition-state complex by cryo-electron microscopy.
    Journal of molecular biology, 2008, Sep-26, Volume: 382, Issue:1

    Topics: Aluminum Compounds; Cryoelectron Microscopy; Fluorides; Fungal Proteins; Guanosine Diphosphate; Guanosine Triphosphate; Hydrolysis; Models, Molecular; Peptide Elongation Factor 2; Protein Structure, Tertiary; Ribosomes

2008
Ensemble cryo-EM uncovers inchworm-like translocation of a viral IRES through the ribosome.
    eLife, 2016, 05-09, Volume: 5

    Topics: Cryoelectron Microscopy; Dicistroviridae; Guanosine Triphosphate; Image Processing, Computer-Assisted; Internal Ribosome Entry Sites; Macromolecular Substances; Nucleic Acid Conformation; Peptide Elongation Factor 2; Protein Biosynthesis; Ribosomes; RNA, Messenger; RNA, Viral; Saccharomyces cerevisiae

2016
Eukaryotic translation elongation factor 2 (eEF2) catalyzes reverse translocation of the eukaryotic ribosome.
    The Journal of biological chemistry, 2018, 04-06, Volume: 293, Issue:14

    Topics: Animals; Escherichia coli; Eukaryota; Eukaryotic Cells; Guanosine Triphosphate; Humans; Models, Molecular; Peptide Chain Elongation, Translational; Peptide Elongation Factor 2; Peptide Elongation Factor G; Peptide Elongation Factors; Protein Binding; Protein Biosynthesis; Rabbits; Recombinant Proteins; Ribosomes; RNA, Messenger; RNA, Transfer; RNA, Transfer, Amino Acyl

2018
The C-terminal helix of ribosomal P stalk recognizes a hydrophobic groove of elongation factor 2 in a novel fashion.
    Nucleic acids research, 2018, 04-06, Volume: 46, Issue:6

    Topics: Amino Acid Sequence; Archaeal Proteins; Guanosine Diphosphate; Guanosine Triphosphate; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Peptide Elongation Factor 2; Protein Binding; Protein Conformation; Pyrococcus horikoshii; Ribosomal Proteins; Ribosomes; Sequence Homology, Amino Acid

2018
Structural Insights into the Role of Diphthamide on Elongation Factor 2 in mRNA Reading-Frame Maintenance.
    Journal of molecular biology, 2018, 08-17, Volume: 430, Issue:17

    Topics: Cryoelectron Microscopy; Guanosine Triphosphate; Histidine; Hydrolysis; Models, Molecular; Peptide Elongation Factor 2; Protein Biosynthesis; Protein Conformation; Ribosomes; RNA, Messenger; RNA, Transfer; Saccharomyces cerevisiae

2018
tRNA Translocation by the Eukaryotic 80S Ribosome and the Impact of GTP Hydrolysis.
    Cell reports, 2018, 12-04, Volume: 25, Issue:10

    Topics: Animals; Bacteria; Guanosine Triphosphate; Humans; Hydrolysis; Internal Ribosome Entry Sites; Mammals; Models, Molecular; Peptide Elongation Factor 2; Protein Domains; Ribosomes; RNA, Messenger; RNA, Transfer

2018
The natural bicyclic hexapeptide RA-VII is a novel inhibitor of the eukaryotic translocase eEF2.
    Biochemical and biophysical research communications, 2022, 07-30, Volume: 615

    Topics: Animals; Eukaryota; Eukaryotic Cells; Guanosine Triphosphate; Peptide Elongation Factor 2; Peptides, Cyclic

2022
Sordarin bound eEF2 unlocks spontaneous forward and reverse translocation on CrPV IRES.
    Nucleic acids research, 2023, 07-21, Volume: 51, Issue:13

    Topics: Guanosine Triphosphate; Internal Ribosome Entry Sites; Peptide Elongation Factor 2; Protein Biosynthesis; RNA, Viral

2023