Page last updated: 2024-08-26

peptide elongation factor 2 and diphthamide

peptide elongation factor 2 has been researched along with diphthamide in 54 studies

Research

Studies (54)

Timeframe	Studies, this research(%)	All Research%
pre-1990	15 (27.78)	18.7374
1990's	8 (14.81)	18.2507
2000's	8 (14.81)	29.6817
2010's	18 (33.33)	24.3611
2020's	5 (9.26)	2.80

Authors

Authors	Studies
Fendrick, JL; Iglewski, WJ; Moehring, JM; Moehring, TJ	1
Foley, BT; Moehring, JM; Moehring, TJ	1
Bodley, JW; Donovan, MG; Veldman, SA	1
Bodley, JW; Miller, SP; Perentesis, JP	1
Davydova, EK	1
Carson, DA; Kubota, M; Olavi, E; Wasson, DB; Willis, EH; Yamanaka, H	1
Kohno, K; Omura, F; Uchida, T	1
Kohno, K; Uchida, T	1
Bodley, JW; Chen, JY	1
Carson, DA; Kajander, EO; Yamanaka, H	1
Moehring, JM; Moehring, TJ	2
Bodley, JW; Oppenheimer, NJ	1
Bodley, JW; Dunlop, PC	1
Bodley, JW; Dunlop, PC; VanNess, BG	1
Adolph, KW; Bodley, JW; Dunlop, PC; Pappenheimer, AM	1
Danley, DE; Moehring, JM; Moehring, TJ	1
Bodley, JW; Howard, JB; Van Ness, BG	1
Barrowclough, B; Bodley, JW; Van Ness, BG	1
Kimata, Y; Kohno, K	1
Bodley, JW; Perentesis, JP; Phan, LD	1
Iwawaki, T; Kimata, Y; Kohno, K; Saito, M	1
Merrill, AR; Prentice, GA	1
Leppla, SH; Liu, S	1
Fink, GR; Kuremsky, JG; Leppla, SH; Liu, S; Milne, GT	1
Kohno, K; Miyagawa, K; Nobukuni, Y	1
Andersen, GR; Jørgensen, R; Merrill, AR	1
Brdar, B; Ivankovic, M; Matulic, M; Reich, E; Rubelj, I	1
Batavia, MP; Gupta, PK; Leppla, SH; Liu, S	1
Cross, SH; Edgar, R; Harrison, J; Jackson, IJ; McKie, L; Peters, J; Vizor, L; Webb, TR	1
Brummelkamp, TR; Carette, JE; Cochran, BH; Godarova, A; Guimaraes, CP; Kotecki, M; Park, AS; Ploegh, HL; Spooner, E; Varadarajan, M; Wuethrich, I	1
Gupta, PK; Leppla, SH; Liu, S	1
Kim, J; Lin, H; Su, X; Zhu, X	1
Jäger, D; Müller-Werdan, U; Werdan, K	1
Altmann, M; Bütikofer, P; Greganova, E	1
Bachran, C; Crown, D; Fattah, R; Gupta, P; Leppla, SH; Liu, S; Miller-Randolph, S; Singh, R; Wang, H; Wein, AN; Zhang, Y	1
Bera, TK; Chertov, O; Colantonio, S; Pastan, I; Wayne, AS; Wei, H; Xiang, L	1
Argüelles, S; Ayala, A; Camandola, S; Cutler, RG; Mattson, MP	1
Abdel-Fattah, W; Klassen, R; Schaffrath, R; Stark, MJ	1
Birzele, F; Brinkmann, U; da Silva Mateus Seidl, AR; Ducret, A; Gerg, M; Haas, AK; Kux van Geijtenbeek, S; Michel, S; Niederfellner, G; Pastan, I; Racek, T; Rueger, R; Stahl, S	1
Billod, JM; Blomberg, A; Eriksson, LA; Saenz-Mendez, P	1
Fleck, O; Knapp, K; Villahermosa, D	1
Demeshkina, N; Hashem, Y; Mancera-Martinez, E; Melnikov, S; Myasnikov, A; Pellegrino, S; Simonetti, A; Yusupov, M; Yusupova, G	1
Eriksson, LA; Hörberg, J; Saenz-Mendez, P	1
Baker, BJ; Caceres, EF; Ettema, TJG; Miller, CS; Narrowe, AB; Spang, A; Stairs, CW	1
Dong, M; Lin, H; Zhang, Y	1
Miura, M; Tsuda-Sakurai, K	1
Adrian, L; Arend, M; Brinkmann, U; Hawer, H; Mayer, K; Schaffrath, R; Ütkür, K	1
Dong, M; Ealick, SE; Fenwick, MK; Lin, H	1
Kimura, M; Miura, M; Tsuda-Sakurai, K	1
Chandrasekaran, S; Coleman, R; Crane, BR; Dzikovski, B; Fenwick, MK; Freed, JH; Lancaster, KM; Lin, H; Majer, SH; Su, D; Zhang, Y	1
Lin, H; Lin, Z; Wang, M; Zhang, Y; Zhu, J	1
Cao, C; Dever, TE; Ivanov, IP; Kim, JR; Kinzy, TG; Shin, BS	1
Brinkmann, U; Klassen, R; Mayer, K; Schaffrath, R; Schmidt, S; Ütkür, K	1

Reviews

6 review(s) available for peptide elongation factor 2 and diphthamide

Article	Year
Protein toxin inhibitors of protein synthesis. BioFactors (Oxford, England), 1992, Volume: 3, Issue:3 Topics: Histidine; Peptide Elongation Factor 2; Peptide Elongation Factors; Poly(ADP-ribose) Polymerases; Protein Synthesis Inhibitors; Toxins, Biological	1992
[Analyses of cell function using diphtheria toxin]. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 1998, Volume: 43, Issue:1 Topics: Amino Acid Sequence; Animals; Chimera; Diphtheria Toxin; Endocytosis; Heparin-binding EGF-like Growth Factor; Histidine; Humans; Intercellular Signaling Peptides and Proteins; Mice; Mice, Transgenic; Molecular Sequence Data; Mutation; Peptide Elongation Factor 2; Peptide Elongation Factors; Poly(ADP-ribose) Polymerases; Receptors, Cell Surface	1998
The life and death of translation elongation factor 2. Biochemical Society transactions, 2006, Volume: 34, Issue:Pt 1 Topics: Amino Acid Sequence; Bacterial Proteins; Fungal Proteins; Histidine; Models, Molecular; Molecular Sequence Data; Peptide Elongation Factor 2; Protein Biosynthesis; Protein Conformation; RNA, Transfer	2006
Unique modifications of translation elongation factors. The FEBS journal, 2011, Volume: 278, Issue:15 Topics: Animals; Eukaryotic Initiation Factor-5; Histidine; Humans; Lysine; Peptide Elongation Factor 1; Peptide Elongation Factor 2; Phosphatidylethanolamines; Protein Processing, Post-Translational	2011
The diphthamide modification pathway from Saccharomyces cerevisiae--revisited. Molecular microbiology, 2014, Volume: 94, Issue:6 Topics: Evolution, Molecular; Histidine; Peptide Elongation Factor 2; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins	2014
The hidden nature of protein translational control by diphthamide: the secrets under the leather. Journal of biochemistry, 2019, Jan-01, Volume: 165, Issue:1 Topics: Animals; Biological Evolution; Cell Proliferation; Diphtheria; Diphtheria Toxin; Histidine; Humans; Internal Ribosome Entry Sites; Peptide Chain Elongation, Translational; Peptide Elongation Factor 2; Protein Processing, Post-Translational; Stem Cells	2019

Other Studies

48 other study(ies) available for peptide elongation factor 2 and diphthamide

Article	Year
Characterization of the endogenous ADP-ribosylation of wild-type and mutant elongation factor 2 in eukaryotic cells. European journal of biochemistry, 1992, Apr-01, Volume: 205, Issue:1 Topics: Adenosine Diphosphate Ribose; Animals; Cell Line; Cell Transformation, Viral; CHO Cells; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Cricetinae; Diphtheria Toxin; Electrophoresis, Polyacrylamide Gel; Histidine; Kinetics; Mutation; Peptide Elongation Factor 2; Peptide Elongation Factors; Phosphoric Diester Hydrolases; Poly(ADP-ribose) Polymerases; Precipitin Tests; Snake Venoms; Trypsin	1992
A mutation in codon 717 of the CHO-K1 elongation factor 2 gene prevents the first step in the biosynthesis of diphthamide. Somatic cell and molecular genetics, 1992, Volume: 18, Issue:3 Topics: Adenine; Amino Acid Sequence; Animals; Arginine; Base Sequence; CHO Cells; Codon; Cricetinae; Glycine; Guanine; Histidine; Homozygote; Molecular Sequence Data; Mutation; Peptide Elongation Factor 2; Peptide Elongation Factors; Polymorphism, Restriction Fragment Length	1992
A screening procedure for the intracellular expression of native proteins by Saccharomyces cerevisiae: discrimination of diphtheria toxin-resistant mutants. Yeast (Chichester, England), 1992, Volume: 8, Issue:8 Topics: Collodion; Diphtheria Toxin; Drug Resistance, Microbial; Fungal Proteins; Histidine; Mutagenesis; Peptide Elongation Factor 2; Peptide Elongation Factors; Poly(ADP-ribose) Polymerases; Saccharomyces cerevisiae	1992
[The ADP-ribosylation site and RNA-binding center are located in different regions of the elongation factor EF-2]. Doklady Akademii nauk SSSR, 1986, Volume: 289, Issue:2 Topics: Adenosine Diphosphate Ribose; Amino Acid Sequence; Animals; Binding Sites; Histidine; Nucleoside Diphosphate Sugars; Peptide Elongation Factor 2; Peptide Elongation Factors; Rabbits; RNA	1986
Heterogeneity of the toxic mechanisms of methylthioadenosine in methylthioadenosine phosphorylase deficient murine lymphoma cells. Advances in experimental medicine and biology, 1989, Volume: 253B Topics: Adenosine; Animals; Deoxyadenosines; Diphtheria Toxin; Histidine; Lymphoma; Mice; Mice, Mutant Strains; Pentosyltransferases; Peptide Elongation Factor 2; Peptide Elongation Factors; Purine-Nucleoside Phosphorylase; S-Adenosylmethionine; Thionucleosides; Tumor Cells, Cultured	1989
The histidine residue of codon 715 is essential for function of elongation factor 2. European journal of biochemistry, 1989, Mar-01, Volume: 180, Issue:1 Topics: Adenosine Diphosphate Ribose; Animals; Codon; DNA; Drug Resistance; Histidine; L Cells; Mice; Mutation; Peptide Elongation Factor 2; Peptide Elongation Factors; Promoter Regions, Genetic; Protein Biosynthesis; RNA, Messenger; Toxins, Biological	1989
Highly frequent single amino acid substitution in mammalian elongation factor 2 (EF-2) results in expression of resistance to EF-2-ADP-ribosylating toxins. The Journal of biological chemistry, 1987, Sep-05, Volume: 262, Issue:25 Topics: Adenosine Diphosphate Ribose; ADP Ribose Transferases; Animals; Bacterial Toxins; Cell Line; Cloning, Molecular; Cricetinae; Diphtheria Toxin; DNA; Drug Resistance; Exotoxins; Gene Expression Regulation; Histidine; Peptide Elongation Factor 2; Peptide Elongation Factors; Plasmids; Polymorphism, Restriction Fragment Length; Protein Processing, Post-Translational; Pseudomonas aeruginosa Exotoxin A; Virulence Factors	1987
Biosynthesis of diphthamide in Saccharomyces cerevisiae. Partial purification and characterization of a specific S-adenosylmethionine:elongation factor 2 methyltransferase. The Journal of biological chemistry, 1988, Aug-25, Volume: 263, Issue:24 Topics: Adenosine Diphosphate Ribose; Chromatography, High Pressure Liquid; Diphtheria Toxin; Drug Resistance; Histidine; Kinetics; Methylation; Methyltransferases; Mutation; Peptide Elongation Factor 2; Peptide Elongation Factors; Protein Processing, Post-Translational; Saccharomyces cerevisiae	1988
Modulation of diphthamide synthesis by 5'-deoxy-5'-methylthioadenosine in murine lymphoma cells. Biochimica et biophysica acta, 1986, Sep-19, Volume: 888, Issue:2 Topics: Adenosine; Adenosine Diphosphate Ribose; Animals; Cell Line; Deoxyadenosines; Diphtheria Toxin; Histidine; Lymphoma; Mice; Peptide Elongation Factor 2; Peptide Elongation Factors; Purine-Nucleoside Phosphorylase; S-Adenosylmethionine; Thionucleosides	1986
The post-translational trimethylation of diphthamide studied in vitro. The Journal of biological chemistry, 1988, Mar-15, Volume: 263, Issue:8 Topics: Amino Acids; Animals; Cell Line; Cytosol; Histidine; Methionine; Methylation; Methyltransferases; Peptide Elongation Factor 2; Peptide Elongation Factors; Protein Processing, Post-Translational; Species Specificity	1988
Diphtheria toxin. Site and configuration of ADP-ribosylation of diphthamide in elongation factor 2. The Journal of biological chemistry, 1981, Aug-25, Volume: 256, Issue:16 Topics: Adenosine Diphosphate Ribose; Animals; Bacterial Toxins; Brain; Cattle; Diphtheria Toxin; Histidine; Magnetic Resonance Spectroscopy; NAD+ Nucleosidase; Nucleoside Diphosphate Sugars; Peptide Chain Elongation, Translational; Peptide Elongation Factor 2; Peptide Elongation Factors; Ribonucleosides; Spleen; Swine	1981
Biosynthetic labeling of diphthamide in Saccharomyces cerevisiae. The Journal of biological chemistry, 1983, Apr-25, Volume: 258, Issue:8 Topics: Amino Acids; Chemical Phenomena; Chemistry; Histidine; Hydrolysis; Methionine; Peptide Elongation Factor 2; Peptide Elongation Factors; Saccharomyces cerevisiae	1983
Diphthamide in elongation factor 2: ADP-ribosylation, purification, and properties. Methods in enzymology, 1984, Volume: 106 Topics: Adenosine Diphosphate Ribose; Diphtheria Toxin; Histidine; NAD; Nucleoside Diphosphate Sugars; Peptide Elongation Factor 2; Peptide Elongation Factors; Phosphorus Radioisotopes; Protein Processing, Post-Translational; Radioisotope Dilution Technique	1984
Diphthamide: in vitro biosynthesis. Methods in enzymology, 1984, Volume: 106 Topics: Amino Acids; Animals; Carbon Radioisotopes; Cell Line; Cricetinae; Cricetulus; Female; Histidine; Kinetics; Ovary; Peptide Elongation Factor 2; Peptide Elongation Factors; Protein Processing, Post-Translational; Radioisotope Dilution Technique; S-Adenosylmethionine	1984
Occurrence of diphthamide in archaebacteria. Journal of bacteriology, 1983, Volume: 153, Issue:3 Topics: Adenosine Diphosphate Ribose; Archaea; Bacteria; Histidine; Peptide Elongation Factor 2; Peptide Elongation Factors; Protein Processing, Post-Translational	1983
In vitro biosynthesis of diphthamide, studied with mutant Chinese hamster ovary cells resistant to diphtheria toxin. Molecular and cellular biology, 1984, Volume: 4, Issue:4 Topics: Animals; Cell Line; Cricetinae; Diphtheria Toxin; Drug Resistance; Female; Histidine; Methylation; Mutation; Peptide Elongation Factor 2; Peptide Elongation Factors; Peptide Fragments; Protein Processing, Post-Translational; S-Adenosylmethionine	1984
ADP-ribosylation of elongation factor 2 by diphtheria toxin. NMR spectra and proposed structures of ribosyl-diphthamide and its hydrolysis products. The Journal of biological chemistry, 1980, Nov-25, Volume: 255, Issue:22 Topics: Adenosine Diphosphate Ribose; Diphtheria Toxin; Histidine; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Nucleoside Diphosphate Sugars; Peptide Elongation Factor 2; Peptide Elongation Factors; Ribonucleosides	1980
Recognition of elongation factor 2 by diphtheria toxin is not solely defined by the presence of diphthamide. FEBS letters, 1980, Oct-20, Volume: 120, Issue:1 Topics: Adenosine Diphosphate Ribose; Animals; Diphtheria Toxin; Histidine; Kinetics; Liver; Molecular Weight; Peptide Elongation Factor 2; Peptide Elongation Factors; Rats; Trypsin	1980
Elongation factor 2 mutants deficient in diphthamide formation show temperature-sensitive cell growth. The Journal of biological chemistry, 1994, May-06, Volume: 269, Issue:18 Topics: Amino Acids; Base Sequence; Cell Division; DNA, Recombinant; Genes; Histidine; Hot Temperature; Molecular Sequence Data; Oligodeoxyribonucleotides; Peptide Elongation Factor 2; Peptide Elongation Factors	1994
Saccharomyces cerevisiae elongation factor 2. Mutagenesis of the histidine precursor of diphthamide yields a functional protein that is resistant to diphtheria toxin. The Journal of biological chemistry, 1993, Apr-25, Volume: 268, Issue:12 Topics: Base Sequence; Diphtheria Toxin; DNA, Fungal; Drug Resistance, Microbial; Fungal Proteins; Histidine; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Elongation Factor 2; Peptide Elongation Factors; Saccharomyces cerevisiae	1993
An enzyme-linked immunosorbent assay for the association of the catalytic domain of diphthamide-specific ribosyltransferases to eukaryotic elongation factor-2. Analytical biochemistry, 1999, Aug-01, Volume: 272, Issue:2 Topics: ADP Ribose Transferases; Bacterial Toxins; Binding Sites; Catalytic Domain; Enzyme-Linked Immunosorbent Assay; Exotoxins; Histidine; Kinetics; Niacinamide; Osmolar Concentration; Peptide Elongation Factor 2; Peptide Elongation Factors; Poly(ADP-ribose) Polymerases; Pseudomonas aeruginosa; Pseudomonas aeruginosa Exotoxin A; Virulence Factors	1999
Retroviral insertional mutagenesis identifies a small protein required for synthesis of diphthamide, the target of bacterial ADP-ribosylating toxins. Molecular cell, 2003, Volume: 12, Issue:3 Topics: ADP-Ribosylation Factors; Animals; Bacterial Infections; Bacterial Toxins; CHO Cells; Cricetinae; Eukaryotic Cells; Histidine; Immunity, Innate; Molecular Sequence Data; Molecular Weight; Mutagenesis, Insertional; Mutation; Peptide Elongation Factor 2; Protein Isoforms; Protein Processing, Post-Translational; Repressor Proteins; Retroviridae; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid	2003
Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2. Molecular and cellular biology, 2004, Volume: 24, Issue:21 Topics: Adenosine Diphosphate; Amino Acid Sequence; Animals; CHO Cells; Cloning, Molecular; Cricetinae; Diphtheria Toxin; Drug Resistance; Genes, Fungal; Genetic Complementation Test; Histidine; Humans; Iron-Sulfur Proteins; Mice; Minor Histocompatibility Antigens; Molecular Sequence Data; Molecular Structure; Mutation; Peptide Elongation Factor 2; Phylogeny; Protein Binding; Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Alignment; Tumor Suppressor Proteins	2004
Gene trap mutagenesis-based forward genetic approach reveals that the tumor suppressor OVCA1 is a component of the biosynthetic pathway of diphthamide on elongation factor 2. The Journal of biological chemistry, 2005, Mar-18, Volume: 280, Issue:11 Topics: Adenosine Diphosphate; Animals; Base Sequence; Blotting, Southern; Blotting, Western; CHO Cells; Coloring Agents; Cricetinae; Diphtheria Toxin; DNA, Complementary; Dose-Response Relationship, Drug; Genes, Tumor Suppressor; Genetic Techniques; Histidine; Humans; Mice; Minor Histocompatibility Antigens; Molecular Sequence Data; Mutagenesis; Mutation; Peptide Elongation Factor 2; Phenotype; Plasmids; Polymerase Chain Reaction; Proteins; Retroviridae; Sequence Homology, Nucleic Acid; Tetrazolium Salts; Thiazoles; Toxins, Biological; Tumor Suppressor Proteins	2005
Site-specific mutagenesis of the histidine precursor of diphthamide in the human elongation factor-2 gene confers resistance to diphtheria toxin. Mutation research, 2006, Oct-10, Volume: 609, Issue:1 Topics: Amino Acid Substitution; Cell Proliferation; Diphtheria Toxin; DNA Fragmentation; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; HeLa Cells; Histidine; Humans; Mutagenesis, Site-Directed; Peptide Elongation Factor 2; Transfection	2006
The diphthamide modification on elongation factor-2 renders mammalian cells resistant to ricin. Cellular microbiology, 2008, Volume: 10, Issue:8 Topics: Animals; Chemical Warfare Agents; CHO Cells; Cricetinae; Cricetulus; Drug Resistance; Histidine; Peptide Elongation Factor 2; Protein Processing, Post-Translational; Proteins; Ricin	2008
Diphthamide modification of eEF2 requires a J-domain protein and is essential for normal development. Journal of cell science, 2008, Oct-01, Volume: 121, Issue:Pt 19 Topics: Animals; Carrier Proteins; Chromosomes, Mammalian; Crosses, Genetic; Cytoskeleton; Diphtheria Toxin; Embryo, Mammalian; Embryonic Development; Eye Proteins; Female; Fibroblasts; Genetic Testing; Genotype; Histidine; Homeodomain Proteins; Male; Mice; Mice, Mutant Strains; Mutation; NIH 3T3 Cells; Paired Box Transcription Factors; PAX6 Transcription Factor; Peptide Elongation Factor 2; Protein Structure, Tertiary; Protein Transport; Repressor Proteins; RNA Splicing; Toes	2008
Haploid genetic screens in human cells identify host factors used by pathogens. Science (New York, N.Y.), 2009, Nov-27, Volume: 326, Issue:5957 Topics: Adenosine Diphosphate Ribose; ADP Ribose Transferases; Amino Acid Sequence; Antigens, Bacterial; Bacterial Toxins; Biosynthetic Pathways; Carboxylic Ester Hydrolases; Cell Line, Tumor; Diphtheria Toxin; Exotoxins; Genes; Genetic Testing; Haploidy; Histidine; Host-Pathogen Interactions; Humans; Influenza A Virus, H1N1 Subtype; Methyltransferases; Molecular Sequence Data; Monosaccharide Transport Proteins; Mutagenesis, Insertional; N-Acylneuraminate Cytidylyltransferase; Peptide Elongation Factor 2; Proteins; Pseudomonas aeruginosa Exotoxin A; Virulence Factors	2009
Characterization of a Chinese hamster ovary cell mutant having a mutation in elongation factor-2. PloS one, 2010, Feb-05, Volume: 5, Issue:2 Topics: Adenosine Diphosphate Ribose; Alleles; Amino Acid Sequence; Animals; Blotting, Western; Cell Survival; CHO Cells; Cricetinae; Cricetulus; Drug Resistance; Electrophoresis, Polyacrylamide Gel; Endocytosis; Fluorescence Resonance Energy Transfer; Genotype; Histidine; Molecular Sequence Data; Mutation; Peptide Elongation Factor 2; Protein Biosynthesis; Sequence Homology, Amino Acid; Toxins, Biological	2010
Reconstitution of diphthine synthase activity in vitro. Biochemistry, 2010, Nov-09, Volume: 49, Issue:44 Topics: Archaeal Proteins; Biosynthetic Pathways; Histidine; Methyltransferases; Peptide Elongation Factor 2; Protein Processing, Post-Translational; Pyrococcus horikoshii; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization	2010
Endogenous ADP-ribosylation of elongation factor-2 by interleukin-1β. Molecular and cellular biochemistry, 2011, Volume: 348, Issue:1-2 Topics: ADP Ribose Transferases; Animals; Animals, Newborn; Bacterial Toxins; Cells, Cultured; Exotoxins; Histidine; Humans; Interleukin-1beta; Myocytes, Cardiac; Peptide Elongation Factor 2; Protein Biosynthesis; Protein Processing, Post-Translational; Pseudomonas aeruginosa Exotoxin A; Rats; Recombinant Proteins; Virulence Factors	2011
Diphthamide modification on eukaryotic elongation factor 2 is needed to assure fidelity of mRNA translation and mouse development. Proceedings of the National Academy of Sciences of the United States of America, 2012, Aug-21, Volume: 109, Issue:34 Topics: Adenosine Diphosphate; Animals; Biotin; CHO Cells; Cricetinae; Fibroblasts; Gene Deletion; Histidine; Mice; Mice, Transgenic; Minor Histocompatibility Antigens; Peptide Elongation Factor 2; Peptides; Phenotype; Protein Biosynthesis; Tumor Suppressor Proteins	2012
A modified form of diphthamide causes immunotoxin resistance in a lymphoma cell line with a deletion of the WDR85 gene. The Journal of biological chemistry, 2013, Apr-26, Volume: 288, Issue:17 Topics: Carboxylic Ester Hydrolases; Cell Line, Tumor; Drug Resistance, Neoplasm; Gene Deletion; Histidine; Humans; Immunotoxins; Lymphoma; Methylation; Methyltransferases; Neoplasm Proteins; Peptide Elongation Factor 2; Proteins	2013
Elongation factor 2 diphthamide is critical for translation of two IRES-dependent protein targets, XIAP and FGF2, under oxidative stress conditions. Free radical biology & medicine, 2014, Volume: 67 Topics: Animals; Benzene Derivatives; Cell Survival; CHO Cells; Cricetulus; Fibroblast Growth Factor 2; Gene Expression Regulation; Histidine; Oxidative Stress; Peptide Elongation Factor 2; Protein Biosynthesis; Ribosomes; RNA, Messenger; X-Linked Inhibitor of Apoptosis Protein	2014
Loss of diphthamide pre-activates NF-κB and death receptor pathways and renders MCF7 cells hypersensitive to tumor necrosis factor. Proceedings of the National Academy of Sciences of the United States of America, 2015, Aug-25, Volume: 112, Issue:34 Topics: Apoptosis; Bacterial Proteins; Breast Neoplasms; Carbon-Nitrogen Ligases; Cell Line, Tumor; Diphtheria Toxin; Female; Gene Dosage; Gene Knockout Techniques; Histidine; Humans; Neoplasm Proteins; NF-kappa B; Peptide Elongation Factor 2; Protein Processing, Post-Translational; Receptors, Death Domain	2015
Structures, Properties, and Dynamics of Intermediates in eEF2-Diphthamide Biosynthesis. Journal of chemical information and modeling, 2016, 09-26, Volume: 56, Issue:9 Topics: Computer Simulation; Histidine; Molecular Dynamics Simulation; Mutagenesis; Peptide Elongation Factor 2; Protein Conformation; Saccharomyces cerevisiae	2016
A mutated dph3 gene causes sensitivity of Schizosaccharomyces pombe cells to cytotoxic agents. Current genetics, 2017, Volume: 63, Issue:6 Topics: Codon, Initiator; Cytotoxins; Gene Expression Regulation, Fungal; Genetic Engineering; Genetic Loci; Genetic Markers; Histidine; Hydroxyurea; Indenes; Methyl Methanesulfonate; Mutation; MutS Homolog 3 Protein; Peptide Elongation Factor 2; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Schizosaccharomyces; Schizosaccharomyces pombe Proteins	2017
Structural Insights into the Role of Diphthamide on Elongation Factor 2 in mRNA Reading-Frame Maintenance. Journal of molecular biology, 2018, 08-17, Volume: 430, Issue:17 Topics: Cryoelectron Microscopy; Guanosine Triphosphate; Histidine; Hydrolysis; Models, Molecular; Peptide Elongation Factor 2; Protein Biosynthesis; Protein Conformation; Ribosomes; RNA, Messenger; RNA, Transfer; Saccharomyces cerevisiae	2018
QM/MM Studies of Dph5 - A Promiscuous Methyltransferase in the Eukaryotic Biosynthetic Pathway of Diphthamide. Journal of chemical information and modeling, 2018, 07-23, Volume: 58, Issue:7 Topics: Aspartic Acid; Biosynthetic Pathways; Computer Simulation; Histidine; Methylation; Methyltransferases; Molecular Docking Simulation; Molecular Dynamics Simulation; Peptide Elongation Factor 2; Protein Binding; Protein Conformation; Protein Processing, Post-Translational; Saccharomyces cerevisiae Proteins; Static Electricity	2018
Complex Evolutionary History of Translation Elongation Factor 2 and Diphthamide Biosynthesis in Archaea and Parabasalids. Genome biology and evolution, 2018, 09-01, Volume: 10, Issue:9 Topics: Archaea; Biosynthetic Pathways; Evolution, Molecular; Genome, Archaeal; Histidine; Models, Molecular; Parabasalidea; Peptide Elongation Factor 2	2018
Methods for Studying the Radical SAM Enzymes in Diphthamide Biosynthesis. Methods in enzymology, 2018, Volume: 606 Topics: Alkyl and Aryl Transferases; Archaeal Proteins; Enzyme Assays; Histidine; Peptide Elongation Factor 2; Protein Processing, Post-Translational; Pyrococcus horikoshii; S-Adenosylmethionine	2018
Importance of diphthamide modified EF2 for translational accuracy and competitive cell growth in yeast. PloS one, 2018, Volume: 13, Issue:10 Topics: Amino Acid Substitution; Anisomycin; Caffeine; Cell Division; Cinnamates; Diphtheria Toxin; Gene Deletion; Gene Expression Regulation, Fungal; Histidine; Hygromycin B; Methyltransferases; Peptide Elongation Factor 1; Peptide Elongation Factor 2; Phenotype; Protein Biosynthesis; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sirolimus	2018
The Crystal Structure of Dph2 in Complex with Elongation Factor 2 Reveals the Structural Basis for the First Step of Diphthamide Biosynthesis. Biochemistry, 2019, 10-29, Volume: 58, Issue:43 Topics: Amino Acid Sequence; Archaeal Proteins; Arginine; Catalytic Domain; Crystallography, X-Ray; Deoxyadenosines; Histidine; Methanobrevibacter; Mutagenesis, Site-Directed; Oxidoreductases; Peptide Elongation Factor 2; Protein Binding; Protein Conformation; Protein Domains; Thionucleosides	2019
Diphthamide modification of eEF2 is required for gut tumor-like hyperplasia induced by oncogenic Ras. Genes to cells : devoted to molecular & cellular mechanisms, 2020, Volume: 25, Issue:2 Topics: Animals; Drosophila; Eating; Eukaryota; Gastrointestinal Neoplasms; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Genes, ras; Histidine; Hyperplasia; Male; Peptide Elongation Factor 2; Protein Processing, Post-Translational; Ribosomes; Transcriptome	2020
Dph3 Enables Aerobic Diphthamide Biosynthesis by Donating One Iron Atom to Transform a [3Fe-4S] to a [4Fe-4S] Cluster in Dph1-Dph2. Journal of the American Chemical Society, 2021, 06-30, Volume: 143, Issue:25 Topics: Dithionite; Histidine; Iron; Iron-Sulfur Proteins; Peptide Elongation Factor 2; Repressor Proteins; S-Adenosylmethionine; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins	2021
Diphthamide promotes TOR signaling by increasing the translation of proteins in the TORC1 pathway. Proceedings of the National Academy of Sciences of the United States of America, 2021, 09-14, Volume: 118, Issue:37 Topics: Histidine; Peptide Elongation Factor 2; Protein Processing, Post-Translational; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Signal Transduction; Transcription Factors	2021
eEF2 diphthamide modification restrains spurious frameshifting to maintain translational fidelity. Nucleic acids research, 2023, 07-21, Volume: 51, Issue:13 Topics: Animals; Bacterial Toxins; Codon, Terminator; Frameshifting, Ribosomal; Mammals; Peptide Elongation Factor 2; Protein Biosynthesis; Saccharomyces cerevisiae	2023
Biomolecules, 2023, Nov-16, Volume: 13, Issue:11 Topics: Histidine; Humans; Minor Histocompatibility Antigens; Mutation; Peptide Elongation Factor 2; S-Adenosylmethionine; Saccharomyces cerevisiae; Tumor Suppressor Proteins	2023