peplomycin and deglycobleomycin

peplomycin has been researched along with deglycobleomycin* in 1 studies

Other Studies

1 other study(ies) available for peplomycin and deglycobleomycin

Article	Year
Identification of the internal axial ligand of HO2-cobalt(III)-bleomycin: 1H[15N] HSQC NMR investigation of bleomycin, deglycobleomycin, and their hydroperoxide-cobalt(III) complexes. Biochemistry, 2003, Jun-03, Volume: 42, Issue:21 The identity of the axial ligand contributed by the drug in hydroperoxide-Co(III)-bleomycin and hydroperoxide-Co(III)-deglycobleomycin has been in doubt. With each structure, a combination of (1)H[(15)N] HSQC and HMBC and (1)H COSY and NOESY NMR spectroscopy was used to observe and completely assign the nonaromatic (15)N chemical shifts of natural abundance bleomycin in the two hydroperoxide-Co(III) structures. Together with the (15)N assignments from a published 1D (15)N spectrum, the results permitted the assignment of the primary amine nitrogen to an axial ligand position in both structures. Topics: Bleomycin; Cobalt; Ligands; Magnetic Resonance Spectroscopy; Models, Chemical; Nitrogen; Peplomycin; Protein Binding; Protons; Temperature	2003

Article

Year

Identification of the internal axial ligand of HO2-cobalt(III)-bleomycin: 1H[15N] HSQC NMR investigation of bleomycin, deglycobleomycin, and their hydroperoxide-cobalt(III) complexes.

Biochemistry, 2003, Jun-03, Volume: 42, Issue:21

The identity of the axial ligand contributed by the drug in hydroperoxide-Co(III)-bleomycin and hydroperoxide-Co(III)-deglycobleomycin has been in doubt. With each structure, a combination of (1)H[(15)N] HSQC and HMBC and (1)H COSY and NOESY NMR spectroscopy was used to observe and completely assign the nonaromatic (15)N chemical shifts of natural abundance bleomycin in the two hydroperoxide-Co(III) structures. Together with the (15)N assignments from a published 1D (15)N spectrum, the results permitted the assignment of the primary amine nitrogen to an axial ligand position in both structures.

Topics: Bleomycin; Cobalt; Ligands; Magnetic Resonance Spectroscopy; Models, Chemical; Nitrogen; Peplomycin; Protein Binding; Protons; Temperature

2003