peplomycin and cepharanthine

peplomycin has been researched along with cepharanthine* in 2 studies

Other Studies

2 other study(ies) available for peplomycin and cepharanthine

Article	Year
[Modification of the cytotoxic effect of peplomycin by cepharanthine]. Gan to kagaku ryoho. Cancer & chemotherapy, 1987, Volume: 14, Issue:12 The cytotoxicity of peplomycin modified by cepharanthine, was studied on in vitro cultured Chinese Hamster V-79 cells. Cepharanthine alone showed almost no cytotoxicity on this tumor system. It was revealed that cepharanthine enhanced the cell killing action of peplomycin and also promoted the recovering process from the effects of peplomycin. The enhancing effect increased with an increase of the concentration at the lower concentrations but there were limitations at the higher concentrations. The bi-phasic properties specific to peplomycin on the dose-survival curves were unchanged even in combination with cepharanthine was observed in the recovering process from the effects of peplomycin. From these results, cepharanthine seemed not to affect on the mechanism of action of peplomycin. Topics: Alkaloids; Antineoplastic Agents, Phytogenic; Benzylisoquinolines; Bleomycin; Cell Survival; Cells, Cultured; Drug Synergism; Peplomycin	1987
[PS (peplomycin-silicone) bullet catheter therapy for bladder tumor: combination of hyperthermic treatment and cepharanthine]. Gan to kagaku ryoho. Cancer & chemotherapy, 1984, Volume: 11, Issue:12 Pt 1 A peplomycin-silicone (PS) bullet containing 130 mg peplomycin, which was steadily released over a long period, was prepared. The PS bullet was then affixed to the top of a 3-way balloon catheter, to form a so called "PS bullet catheter". About 80% of the peplomycin was gradually released over 2 weeks from the PS bullet catheter. Using this device hyperthermic treatment using cepharanthine (biscoclaurin ++ alkaloid) in the irrigant was performed in 15 cases of superficial bladder tumor. Five daily hyperthermic treatments were carried out and all patients retained the PS bullet catheter in the urinary bladder for 2 weeks. Marked tumor regression was noted in 10 of the 15 cases. In addition, partial tumor regression occurred in 4 of the remaining 5 cases. None of these cases had irreversible side effects. This therapy had a good effect on superficial bladder tumor and it is considered that the PS bullet catheter would be useful for cancer therapy. Topics: Aged; Alkaloids; Benzylisoquinolines; Bleomycin; Delayed-Action Preparations; Female; Hot Temperature; Humans; Male; Middle Aged; Peplomycin; Silicones; Urinary Bladder; Urinary Bladder Neoplasms; Urinary Catheterization	1984

Article

Year

[Modification of the cytotoxic effect of peplomycin by cepharanthine].

Gan to kagaku ryoho. Cancer & chemotherapy, 1987, Volume: 14, Issue:12

The cytotoxicity of peplomycin modified by cepharanthine, was studied on in vitro cultured Chinese Hamster V-79 cells. Cepharanthine alone showed almost no cytotoxicity on this tumor system. It was revealed that cepharanthine enhanced the cell killing action of peplomycin and also promoted the recovering process from the effects of peplomycin. The enhancing effect increased with an increase of the concentration at the lower concentrations but there were limitations at the higher concentrations. The bi-phasic properties specific to peplomycin on the dose-survival curves were unchanged even in combination with cepharanthine was observed in the recovering process from the effects of peplomycin. From these results, cepharanthine seemed not to affect on the mechanism of action of peplomycin.

Topics: Alkaloids; Antineoplastic Agents, Phytogenic; Benzylisoquinolines; Bleomycin; Cell Survival; Cells, Cultured; Drug Synergism; Peplomycin

1987

[PS (peplomycin-silicone) bullet catheter therapy for bladder tumor: combination of hyperthermic treatment and cepharanthine].

Gan to kagaku ryoho. Cancer & chemotherapy, 1984, Volume: 11, Issue:12 Pt 1

A peplomycin-silicone (PS) bullet containing 130 mg peplomycin, which was steadily released over a long period, was prepared. The PS bullet was then affixed to the top of a 3-way balloon catheter, to form a so called "PS bullet catheter". About 80% of the peplomycin was gradually released over 2 weeks from the PS bullet catheter. Using this device hyperthermic treatment using cepharanthine (biscoclaurin ++ alkaloid) in the irrigant was performed in 15 cases of superficial bladder tumor. Five daily hyperthermic treatments were carried out and all patients retained the PS bullet catheter in the urinary bladder for 2 weeks. Marked tumor regression was noted in 10 of the 15 cases. In addition, partial tumor regression occurred in 4 of the remaining 5 cases. None of these cases had irreversible side effects. This therapy had a good effect on superficial bladder tumor and it is considered that the PS bullet catheter would be useful for cancer therapy.

Topics: Aged; Alkaloids; Benzylisoquinolines; Bleomycin; Delayed-Action Preparations; Female; Hot Temperature; Humans; Male; Middle Aged; Peplomycin; Silicones; Urinary Bladder; Urinary Bladder Neoplasms; Urinary Catheterization

1984