pentylenetetrazole has been researched along with valproic acid in 204 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 42 (20.59) | 18.7374 |
| 1990's | 30 (14.71) | 18.2507 |
| 2000's | 40 (19.61) | 29.6817 |
| 2010's | 68 (33.33) | 24.3611 |
| 2020's | 24 (11.76) | 2.80 |
| Authors | Studies |
|---|---|
| Alkskas, IA; Azam, F; Khokra, SL; Prakash, O | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Stone, WE | 1 |
| Dustman, RE; Fleming, DE; Shearer, DE | 1 |
| Frey, HH; Löscher, W | 1 |
| Bigler, ED; Fleming, DE; Shearer, DE | 1 |
| Mares, P; Stanková, L | 1 |
| Abramova, EM; Abrosimov, IIu; Karpova, MN; Kryzhanovskiĭ, GN; Pankov, OIu | 1 |
| de Angelis, L | 1 |
| Georgiev, VP; Kambourova, TS; Lazarova, MB | 1 |
| Abed, WT | 1 |
| Fredow, G; Löscher, W | 1 |
| Elmazar, MM; Hauck, RS; Nau, H | 2 |
| Czuczwar, SJ; Kleinrok, Z; Małek, U | 1 |
| Jankowicz, E; Kułak, W; Rudziński, P; Sobaniec, W; Sobaniec-Lotowska, M | 1 |
| Mares, P; Maresová, D; Maresová, S | 1 |
| Aburada, M; Hosoya, E; Iizuka, S; Ishige, A; Matsuzaki, Y; Sakamoto, K; Sekiguchi, K; Sugaya, E | 1 |
| Kent, AP; Webster, RA | 1 |
| Bender, AS; Hertz, L | 1 |
| Kryzhanovskiĭ, GN; Shandra, AA | 1 |
| Mares, P; Velísek, L | 1 |
| Durán, JA; Miñano, FJ; Sancibrián, M; Serrano, JS | 1 |
| Lloyd, KG | 1 |
| Vellucci, SV; Webster, RA | 1 |
| Bentley, M; Feely, M; Gent, JP; Haigh, JR | 1 |
| Kolokouris, N; Vamvakidès, A | 1 |
| Bourgeois, BF | 1 |
| Piredda, SG; Swinyard, EA; Woodhead, JH | 1 |
| Hinko, CN; Lee, JA; Moore, JA; Nicholson, JM; Scott, KR; Zalucky, TB | 1 |
| Pollack, GM; Shen, DD | 1 |
| Chweh, AY; Coleman, JC; Shenoy, AK; Swinyard, EA | 1 |
| Keane, PE; Morre, M | 1 |
| Hancock, S; Picker, M; Poling, A; Wallace, S | 1 |
| Dunn, R; Fielding, S; Kruse, H; Lal, H; Shearman, GT; Theurer, K | 1 |
| Kosoĭ, MIu | 1 |
| Morag, M; Myslobodsky, MS | 1 |
| Bendotti, C; Lazarova, M; Samanin, R | 2 |
| Petersen, EN | 1 |
| Keane, PE; Mendes, E; Morre, M; Santucci, V; Simiand, J | 1 |
| Löscher, W; Marescaux, C; Nau, H; Vergnes, M | 1 |
| Bizière, K; Calassi, R; Chambon, JP; Leyris, R; Maruani, J; Molimard, JC; Rodier, D; Roncucci, R; Sigault, G | 1 |
| Lajtha, A; Toth, E | 1 |
| Ciesielski, L; Mandel, P; Simler, S | 1 |
| Mares, P; Maresová, D; Schickerová, R | 1 |
| Kharlamov, AN; Raevskiĭ, KS | 1 |
| Löscher, W | 1 |
| Czuczwar, SJ; Kleinrok, Z; Turski, L; Turski, W | 1 |
| Bruni, J; Hammond, EJ; Wilder, BJ | 1 |
| Ciesielski, L; Klein, M; Mandel, P; Simler, S | 1 |
| Howe, GM; Howe, SJ; Tulloch, IF; Walter, DS | 1 |
| Brumleve, SJ; Chaturvedi, AK; Geiger, JD; Parmar, SS | 1 |
| Fassos, FF; Mucha, RF; Perl, FM | 1 |
| Adkison, KD; Dills, RL; Ojemann, GA; Rapport, RL; Shen, DD | 1 |
| Hönack, D; Löscher, W | 1 |
| Sayin, U; Timmerman, W; Westerink, BH | 1 |
| Asai, M; Massarini, A; Talavera, E; Vindrola, O; Zubieta, M | 1 |
| Kubová, H; Mares, P; Pohl, M; Zelízko, M | 1 |
| Adesioye, S; Ayuk, PB; Edafiogho, IO; John, D; Kodwin, P; Maxwell-Irving, T; Moore, JA; Nicholson, JM; Scott, KR | 1 |
| Duburs, G; Germane, SK; Karpova, MN; Klusha, VE; Pankov, OIu | 1 |
| Becker, A; Brosz, M; Grecksch, G | 1 |
| Brudniak, T; Czuczwar, SJ; Gasior, M; Kamiński, R; Kleinrok, Z | 1 |
| Scriba, GK | 1 |
| Andersen, PH; Burns, CM; Chang, H; Crider, AM; el-Assadi, AA; Hinko, CN; Ho, B; Kliem, MA; Klitgaard, H; Seo, TH; Steinmiller, CL; Tietz, EI; Venkatarangan, P | 1 |
| Chunngam, T; Patarapanich, C; Sooksawate, T; Tantisira, B; Tantisira, MH | 1 |
| David, J; Joseph, S; Joseph, T | 1 |
| Abdel-Hafez, AA; el-Gendy, MA; Hattori, M; Mahfouz, NM; Meselhy, MR; Mohamed, TA; Nakamura, N; Watanabe, H | 1 |
| Fischer, W; van der Goot, H | 1 |
| Armand, V; Heinemann, U; Louvel, J; Pumain, R | 1 |
| Czuczwar, SJ; Kleinrok, Z; Klonowski, P; Tutka, P | 1 |
| Gupta, YK; Malhotra, J | 1 |
| David, J; Joseph, T; Shantilal, P | 1 |
| Balakrishnan, S; Bhargava, VK; Pandhi, P | 1 |
| Beekman, M; Carter, RB; Gasior, M; Ungard, JT; Witkin, JM | 1 |
| Reddy, DS; Rogawski, MA | 2 |
| Ha, JH; Ha, JS; Huh, K; Kim, JA; Kim, JS; Lee, DU; Lee, JT; Yong, CS | 1 |
| David, J; Joseph, T; Kumaresan, S | 1 |
| Alexander, G; Chatterjie, N; Wang, H | 1 |
| Bough, KJ; Eagles, DA | 1 |
| Gupta, YK; Srivastava, AK | 1 |
| Arent, K; Kleinrok, Z; Tutka, P; Wielosz, M; Łuszczki, J | 1 |
| Borowicz, KK; Czuczwar, SJ; Kleinrok, Z; Kowalska, A; Swiader, M; Zadrozniak, M | 1 |
| Armijo, JA; Cuadrado, A; de las Cuevas, I; Valdizán, EM | 1 |
| Amat, G; Armijo, JA; Cuadrado, A | 1 |
| Ji, YH; Li, ZP; Lu, X; Zhang, XY; Zhong, MK | 1 |
| Ayala Guerrero, F; Barragán Mejía, G; Calderón Guzmán, D; Espitia Vázquez, I; Juárez Olguín, H; Labra Ruiz, N; Rodríguez Pérez, R; Santamaria del Angel, D | 1 |
| Biggio, G; Cutrignelli, A; Franco, M; Latrofa, A; Liso, G; Pisu, MG; Serra, M; Trapani, G | 1 |
| Bialer, M; Isoherranen, N; Levy, RH; White, HS; Woodhead, JH; Yagen, B | 1 |
| Bialer, M; Sobol, E; Yagen, B | 1 |
| Borowicz, KK; Czuczwar, SJ; Luszczki, JJ | 1 |
| Czuczwar, SJ; Dekundy, A; Kaminski, RM; Tochman, AM; Turski, WA | 1 |
| Arban, R; Brackenborough, K; Gerrard, P; Large, C; Maraia, G; Wilson, A; Winyard, L | 1 |
| Armijo, JA; Cuadrado, A | 1 |
| Armutcu, F; Gurel, A; Ilhan, A; Iraz, M; Kamisli, S | 1 |
| Czuczwar, SJ; Luszczki, JJ; Patsalos, PN; Ratnaraj, N | 2 |
| Bennani, Y; Bitner, RS; Chemburkar, SR; Chen, J; Curzon, P; Dart, MJ; Decker, MW; Durmuller, N; Fox, GB; Giardina, WJ; Grayson, GK; Harris, RR; Hui, JY; Jolly, R; Komater, VA; Ku, Y; Lockwood, M; Marsh, KC; Miner, HM; Nikkel, AL; Pan, JB; Pu, YM; Radek, RJ; Roux, S; Sullivan, JP; Wang, L; Waring, JF | 1 |
| Gupta, RK; Tandon, VR | 1 |
| Abe, K; Arai, T; Hasebe, N; Horiuchi, M; Kimura, M; Tokumura, M | 1 |
| Pillai, KK; Uma Devi, P; Vohora, D | 1 |
| Ilhan, A; Iraz, M; Kamisli, S; Yigitoglu, R | 1 |
| Calderon, A; Palencia, G; Sotelo, J | 1 |
| Bruno-Blanch, LE; Echeverría, GA; Ellena, J; Moon, SC; Punte, G | 1 |
| Bialer, M; Finnell, RH; Pessah, N; Shimshoni, JA; Wlodarczyk, B; Yagen, B | 1 |
| Czapp, M; Hoffmann, K; Löscher, W | 1 |
| Chakrabarti, A; Medhi, B; Sahai, AK; Sood, N | 1 |
| Park, JY; Park, MS; Sharma, G | 1 |
| Krzyzanowski, M; Luszczki, JJ; Swiader, MJ | 1 |
| Andres-Mach, MM; Czuczwar, SJ; Dudra-Jastrzebska, M; Luszczki, JJ; Patsalos, PN; Ratnaraj, N | 1 |
| Bialer, M; Finnell, RH; Schurig, V; Shimshoni, JA; Wlodarczyk, B; Yagen, B | 1 |
| Bialer, M; Fujiwara, M; Noyori, H; Okada, A; Shimshoni, JA; Yagen, B | 1 |
| Bialer, M; Devor, M; Kaufmann, D; Shimshoni, JA; Yagen, B | 1 |
| Ishihara, S; Ohno, Y; Sasa, M; Serikawa, T; Terada, R | 1 |
| Abdallah, DM; Abdel-Aziz, MT; Arafa, NM; Safar, MM | 1 |
| Arcieri, S; Coppola, G; D'Aniello, A; Messana, T; Pascotto, A; Signoriello, G; Verrotti, A | 1 |
| Abd El-Latif, HA; Abu Yossef, HA; Hassan, GS; Ragab, FA; Yahya, TA | 1 |
| Sathyanarayana Rao, KN; Subbalakshmi, NK | 1 |
| Abdallah, DM | 1 |
| Kim, D; Kim, YH; Lee, CJ; Lee, H; Lee, Y | 1 |
| Bialer, M; Finnell, RH; Hen, N; Kaufmann, D; Pessah, N; Wlodarczyk, B; Yagen, B | 1 |
| Xie, W; Yu, Y; Zhao, Y | 1 |
| El-Agamy, DS; Said, SA | 1 |
| Chen, L; Feng, Q; Ji, YH; Wang, Y; Weng, CC; Zhang, XY; Zhao, R; Zhu, HY | 1 |
| Desai, PV; Therisa, KK | 1 |
| Andres-Mach, M; Barcicka-Klosowska, B; Czuczwar, SJ; Florek-Luszczki, M; Haratym-Maj, A; Luszczki, JJ | 1 |
| Bialer, M; Finnell, RH; Hen, N; Pessah, N; Shimshoni, JA; Wlodarczyk, B; Yagen, B | 1 |
| Bialer, M; Shekh-Ahmad, T; Yavin, E | 1 |
| Azimi, M; Habibian, S; Kaboutari, J; Karimi, B; Shaker, M; Zendehdel, M | 1 |
| Gupta, YK; Katyal, J; Sarangal, V | 1 |
| Maciejak, P; Płaźnik, A; Sobolewska, A; Szyndler, J; Turzyńska, D | 1 |
| Afrikanova, T; Alen, J; Crawford, AD; De Borggraeve, W; de Witte, PA; Esguerra, CV; León-Tamariz, F; Maes, J; Orellana-Paucar, AM; Serruys, AS; Wilches-Arizábala, IM | 1 |
| El-Azab, MF; Moustafa, YM | 1 |
| Beattie, CE; Hall, CW; Pineda, R | 1 |
| Azhdari-Zarmehri, H; Golmohammadi, R; Mohammad-Zadeh, M; Pejhan, A | 1 |
| Borowicz, KK; Czuczwar, SJ; Piskorska, B; Stępniak, B | 1 |
| Abdel-Rahman, M; Arafa, NM; El-khadragy, MF; Kassab, RB | 1 |
| Chang, P; Chen, PE; Plant, N; Terbach, N; Walker, MC; Williams, RS | 1 |
| Bogo, MR; Bonan, CD; Nery, LR; Piato, AL; Schaefer, IC; Siebel, AM | 1 |
| Daniels, JS; Days, E; Denton, J; Du, Y; Kaufmann, K; Lindsley, CW; Malik, A; Morrison, RD; Niswender, CM; Pascual, C; Romaine, I; Sliwoski, G; Sulikowski, GA; Weaver, CD; Xie, XS; Yang, L; Zou, B | 1 |
| Bialer, M; Hen, N; Kubová, H; Mareš, P; Yagen, B | 1 |
| Chang, P; Walker, MC; Williams, RS | 1 |
| Avinash, H; Chandrashekar, BR; Mukunda, N; Naduvil Narayanan, S; Nayak, BS; Raghavendra Rao, K; Sadhana, N; Satish Kumar, MC; Snehunsu, A; Vijay Kapgal, K | 1 |
| Gmiro, VE; Serdiuk, SE; Veselkina, OS | 2 |
| Mehndiratta, M; Pillai, KK; Singh, E | 1 |
| Abdel-Aziz, AA; Abdel-Dayem, MA; El-Mowafy, AM; Elmarakby, AA; Pye, C; Said, SA | 1 |
| Nieoczym, D; Raszewski, G; Socała, K; Wlaź, P | 1 |
| Filipek, B; Kamiński, K; Obniska, J; Rapacz, A; Rybka, S | 1 |
| Jiang, W; Wang, Y; Wei, D; Wu, C; Wu, SX; Yang, F | 1 |
| Aizenman, CD; Gu, J; Hasan, M; James, EJ; Khakhalin, AS; Oupravanh, PM; Ramirez-Vizcarrondo, CM; Tan, Y; Truszkowski, TL | 1 |
| Babapour, V; Gavzan, H; Sardari, S; Sayyah, M | 1 |
| Ghosal, C; Joseph, A; Kamath, SU; Kandwal, M; Kumar, S; Naduvil Narayanan, S; Nayak, BS; Rao, KR; Sahoo, P; Snehunsu, A; Srinivasan, KK; Yadav, PK | 1 |
| Akula, KK; Boison, D; Coffman, SQ; Lusardi, TA; Masino, SA; Ruskin, DN | 1 |
| Feng, XZ; Lee, J; Li, L; Lu, L; Pfister, D; Sun, MZ; Wang, YL; Wang, YN; Zhao, SS; Zhao, X | 1 |
| Borowicz, KK; Popławska, M; Wróblewska, D | 1 |
| Díaz, FV; Rasgado, LA; Reyes, GC | 1 |
| Anisimova, VA; Grechko, OY; Kalitin, KY; Spasov, AA | 1 |
| Karpova, MN; Klishina, NV; Kuznetsova, LV; Zin'kovskii, KA | 1 |
| Löscher, W; Töllner, K; Twele, F | 1 |
| Behra, M; Bradsher, JN; Colón, LR; González-Sepúlveda, L; Miscalichi, N; Ortíz, JG; Pérez-Ríos, N; Rosa-Falero, C; Suárez-Pérez, E; Torrado, A; Torres-Hernández, BA | 1 |
| Deepakumari, HN; Jayanna, BK; Prashanth, MK; Revanasiddappa, HD; Veeresh, B | 1 |
| Blanco, MM; Cinini, SM; Lima, TZ; Mello, LE; Pontes, JC; Queiroz, CM | 1 |
| Goel, RK; Singh, T | 2 |
| Al-Shorbagy, MY; Nassar, NN | 1 |
| Abdel-Kawy, HS; El Serafy, OMH; Hasanin, AH; Hassan, OA; Raafat, MH; Sedky, AA | 1 |
| Aouam, K; Ben-Attia, M; Boughattas, NA; Dridi, I; Khedhaier, WBC; Reinberg, A | 1 |
| Gupta, YK; Joshi, D; Kaleekal, T; Kumar, R; Sarangi, SC | 1 |
| Ashour, RH; El-Beltagi, HM; Hamada, NM; Shalaby, AA | 1 |
| Song, DQ; Tang, S; Zhang, JP; Zheng, YM | 1 |
| Algul, S; Ergul Erkec, O; Kara, M | 1 |
| Gmiro, VE; Serdyuk, SE; Veselkina, OS | 1 |
| Kenawy, SA; Lotfy, DM; Mohamed, SH; Safar, MM | 1 |
| Arava, S; Gupta, YK; Joshi, D; Katyal, J | 1 |
| Jand, A; Mousavi-Hasanzadeh, M; Palizvan, MR; Rezaeian-Varmaziar, H; Shafaat, O | 1 |
| Abram, M; Andres-Mach, M; Esguerra, CV; Gawel, K; Jakubiec, M; Kamiński, K; Latacz, G; Lubelska, A; Nieoczym, D; Pieróg, M; Rapacz, A; Socała, K; Szewczyk, A; Szulczyk, B; Wlaź, P; Zagaja, M; Łuszczki, JJ | 1 |
| Chen, TC; Chen, Y; Fu, J; He, H; Peng, L; Wang, W; Zeng, S | 1 |
| Avagliano, C; Calignano, A; Citraro, R; Constanti, A; De Caro, C; De Sarro, G; di Cesare Mannelli, L; Ghelardini, C; Leo, A; Mainardi, P; Nesci, V; Russo, E; Striano, P | 1 |
| Dinda, AK; Gupta, YK; Kottarath, SK; Meenu, M; Reeta, KH | 1 |
| Goel, RK; Kaur, S; Sharma, NK | 1 |
| Czuczwar, SJ; Krzyżanowski, M; Świąder, K; Świąder, MJ; Wróbel, A; Zakrocka, I; Łuszczki, JJ | 1 |
| Abdelsameea, AA; Elgarhi, R; Salem, AE; Shehata, MM | 1 |
| Hu, L; Li, Q; Li, X; Li, Y; Li, Z; Lu, J; Tao, J; Wang, G; Wang, Y | 1 |
| Abram, M; Góra, M; Jakubiec, M; Kamiński, K; Obniska, J; Rapacz, A; Rybka, S; Sałat, K | 1 |
| Agarwal, A; Arora, R; Ganeshan N, S; Gupta, YK; Kaleekal, T; Kumar, R; Sarangi, SC | 1 |
| Kavaye Kandeda, A; Mbomo Ayissi, RE; Ngo Bum, E; Ojong, L; Okomolo Moto, FC; Omam Omam, JP | 1 |
| Hussain, M; Katyal, J; Rashid, H | 1 |
| Ho, YJ; Hung, CS; Jao, HT; Li, HH; Liao, WC; Lin, CL; Lin, PJ; Liu, CH; Liu, WY; Tseng, LH; Tung, H; Wang, WH | 1 |
| Abdel-Daim, MM; Almeer, R; Kamel, M; Najda, A; Nurzyńska-Wierdak, R; Singh, M; Singh, S; Singh, TG | 1 |
| Chang, H; Chang, SF; Tsai, CM | 1 |
| Amanvermez, R; Arslan, G; Gün, S; Rzayev, E; Tiryaki, ES | 1 |
| Feng, Y; Guo, J; Li, X; Lu, S; Pang, W; Wang, S; Yang, S; Zheng, R; Zhou, S | 1 |
| Ikeda, Y; Nagasaki, Y; Tajika, Y | 1 |
| Singh, S; Singh, TG | 1 |
| Li, Y; Li, Z; Lu, J; Wang, G; Wang, Y | 1 |
| Abnous, K; Gorji Valokola, M; Heydari, FS; Mehri, S; Roohbakhsh, A | 1 |
| Ayala-Guerrero, F; Castro-Domínguez, D; Gutiérrez-Chávez, CA; Mateos-Salgado, EL; Mexicano-Medina, G | 1 |
| Ahlatcı, A; Bektaş, M; Tülüce, Y; Yıldızhan, K | 1 |
| Bertoncello, KT; Bonan, CD | 1 |
| Dongxiao, QU; Guoyi, LI; Jie, T; Jiwei, C; Liji, C; Limin, Z; Qian, X; Yiqin, GE; Yonghua, X; Yudan, Z | 1 |
| Budzyńska, B; Gertsch, J; Kozioł, E; Lee, SM; Morozova, V; Pellegata, D; Skalicka-Woźniak, K; Skiba, A | 1 |
| Gorbach, T; Lytkin, D; Mishchenko, M; Shtrygol, D; Shtrygol, S; Taran, A; Tsyvunin, V | 1 |
1 review(s) available for pentylenetetrazole and valproic acid
| Article | Year |
|---|---|
[GABAergic theory of epilepsy].
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Benzodiazepines; Bicuculline; Brain; Dogs; Epilepsy; gamma-Aminobutyric Acid; Humans; Mice; Nerve Endings; Pentylenetetrazole; Phenobarbital; Phenytoin; Rats; Receptors, GABA-A; Synapses; Valproic Acid | 1986 |
1 trial(s) available for pentylenetetrazole and valproic acid
| Article | Year |
|---|---|
Effects of fluoxetine on the anticonvulsant action of valproate and ethosuximide in mouse model of myoclonic convulsions.
Topics: Animals; Anticonvulsants; Antidepressive Agents, Second-Generation; Avoidance Learning; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Epilepsies, Myoclonic; Ethosuximide; Fluorescent Antibody Technique; Fluoxetine; Male; Memory, Long-Term; Mice; Motor Activity; Pentylenetetrazole; Seizures; Selective Serotonin Reuptake Inhibitors; Valproic Acid | 2012 |
202 other study(ies) available for pentylenetetrazole and valproic acid
| Article | Year |
|---|---|
Synthesis of some novel N4-(naphtha[1,2-d]thiazol-2-yl)semicarbazides as potential anticonvulsants.
Topics: Animals; Anticonvulsants; Brain Chemistry; Glutathione Peroxidase; Malondialdehyde; Mice; Motor Activity; Rats; Seizures; Semicarbazides; Structure-Activity Relationship; Superoxide Dismutase | 2009 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Effects of alterations in the metabolism of gamma-aminobutyrate on convulsant potencies.
Topics: 3-Mercaptopropionic Acid; Aminobutyrates; Aminooxyacetic Acid; Animals; Bicuculline; Diacetyl; Drug Synergism; gamma-Aminobutyric Acid; Glycine; Hydrazines; Male; Mice; Pentylenetetrazole; Phenelzine; Picrotoxin; Pyridoxine; Reaction Time; Seizures; Thiones; Valproic Acid | 1977 |
Effects of dipropylacetic acid on late components of the photically evoked potential and afterdischarge in rat.
Topics: Animals; Evoked Potentials; Male; Pentylenetetrazole; Photic Stimulation; Rats; Valerates; Valproic Acid | 1978 |
Di-n-propylacetic acid--profile of anticonvulsant activity in mice.
Topics: Animals; Anticonvulsants; Bicuculline; Dose-Response Relationship, Drug; Electroshock; Ethosuximide; Female; Male; Mice; Pentylenetetrazole; Phenobarbital; Picrotoxin; Seizures; Strychnine; Trimethadione; Valerates; Valproic Acid | 1976 |
The photically evoked afterdischarge: a model for the study of drugs useful in the treatment of petit mal epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy, Absence; Evoked Potentials; Female; Pentylenetetrazole; Phenytoin; Rats; Sodium Chloride; Trimethadione; Valproic Acid | 1976 |
Influence of phenobarbital on ECoG phenomena induced by metrazol in rats during ontogenesis.
Topics: Aging; Animals; Cerebral Cortex; Clonazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Electrodes; Electroencephalography; Epilepsy; Ethosuximide; Injections, Intraperitoneal; Male; Pentylenetetrazole; Phenobarbital; Prohibitins; Rats; Rats, Wistar; Valproic Acid | 1992 |
[The antiepileptic effects of sodium valproate and the calcium antagonist riodipine when used jointly in a model of generalized korazol-induced epileptic activity].
Topics: Animals; Calcium Channel Blockers; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Synergism; Drug Therapy, Combination; Epilepsy, Generalized; Male; Nifedipine; Pentylenetetrazole; Rats; Rats, Wistar; Valproic Acid | 1992 |
The anxiogenic-like effects of pentylenetetrazole in mice treated chronically with carbamazepine or valproate.
Topics: Animals; Anxiety; Behavior, Animal; Carbamazepine; Female; Lorazepam; Mice; Pentylenetetrazole; Valproic Acid | 1992 |
Interactions between angiotensin II, diazepam, clonazepam and di-n-propylacetate in pentylenetetrazol kindling seizures in mice.
Topics: Angiotensin II; Animals; Clonazepam; Diazepam; Drug Interactions; Electric Stimulation; Ionophores; Kindling, Neurologic; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures; Valproic Acid | 1991 |
Anticonvulsant activity of di-n-propylacetate and brain monoamine metabolism in the rat.
Topics: Animals; Biogenic Monoamines; Brain; Catecholamines; Epilepsy; Female; gamma-Aminobutyric Acid; Homovanillic Acid; Hydroxyindoleacetic Acid; Male; Pentylenetetrazole; Probenecid; Rats; Rats, Inbred Strains; Serotonin; Valproic Acid | 1990 |
Effects of pharmacological manipulation of GABAergic neurotransmission in a new mutant hamster model of paroxysmal dystonia.
Topics: Animals; Baclofen; Carbamazepine; Cricetinae; Diazepam; Disease Models, Animal; Dystonia; gamma-Aminobutyric Acid; Mesocricetus; Mutation; Pentylenetetrazole; Phenobarbital; Phenytoin; Synaptic Transmission; Valproic Acid | 1991 |
On the development of alternative antiepileptic drugs. Lack of enantioselectivity of the anticonvulsant activity, in contrast to teratogenicity, of 2-n-propyl-4-pentenoic acid and 2-n-propyl-4-pentynoic acid, analogues of the anticonvulsant drug valproic
Topics: Animals; Anticonvulsants; Drug Design; Fatty Acids, Monounsaturated; Fatty Acids, Unsaturated; Female; Mice; Mice, Inbred Strains; Pentylenetetrazole; Pregnancy; Regression Analysis; Seizures; Stereoisomerism; Teratogens; Valproic Acid | 1991 |
Influence of calcium channel inhibitors upon the anticonvulsant efficacy of common antiepileptics against pentylenetetrazol-induced convulsions in mice.
Topics: Animals; Anticonvulsants; Calcium Channel Blockers; Diltiazem; Drug Therapy, Combination; Ethosuximide; Male; Mice; Nifedipine; Pentylenetetrazole; Phenobarbital; Reference Values; Seizures; Valproic Acid; Verapamil | 1990 |
Cardiazol-induced seizures and the concentration of lipid peroxides in the brain of rats under the influence of valproic acid and vitamin E.
Topics: Animals; Anticonvulsants; Antioxidants; Cerebral Cortex; Convulsants; Drug Therapy, Combination; Epilepsy; Hippocampus; Lipid Peroxides; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Valproic Acid; Vitamin E | 1989 |
Antimetrazol action and plasma levels of valproate in developing rats.
Topics: Aging; Animals; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures; Time Factors; Valproic Acid | 1989 |
Effect of anticonvulsants on pentylenetetrazol-induced power spectrum changes in electroencephalograms in rats.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Cyclic AMP; Electroencephalography; Ethosuximide; Male; Pentylenetetrazole; Phenobarbital; Rats; Rats, Inbred Strains; Seizures; Valproic Acid | 1987 |
The role of GABA and excitatory amino acids in the development of the leptazol-induced epileptogenic EEG.
Topics: Allylglycine; Amino Acids; Animals; Bicuculline; Cerebral Cortex; Clonazepam; Dose-Response Relationship, Drug; Electroencephalography; GABA Antagonists; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Seizures; Time Factors; Valproic Acid | 1986 |
Evidence for involvement of the astrocytic benzodiazepine receptor in the mechanism of action of convulsant and anticonvulsant drugs.
Topics: Animals; Anticonvulsants; Astrocytes; Barbiturates; Benzodiazepinones; Brain; Carbamazepine; Cells, Cultured; Convulsants; Diazepam; Ethosuximide; Mice; Neurons; Pentylenetetrazole; Phenobarbital; Picrotoxin; Receptors, GABA-A; Sesterterpenes; Trimethadione; Valproic Acid | 1988 |
[Effect of diazepam, carbamazepine, sodium valproate and their combinations with vitamin preparations on epileptic activity].
Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Drug Therapy, Combination; Male; Niacinamide; Pentylenetetrazole; Pyridoxal Phosphate; Rats; Seizures; Valproic Acid; Vitamin E; Vitamins | 1985 |
Influence of ethosuximide and dipropylacetate on metrazol-induced electrocorticographic changes during ontogenesis in rats.
Topics: Animals; Brain; Electroencephalography; Ethosuximide; Pentylenetetrazole; Rats; Rats, Inbred Strains; Theta Rhythm; Valproic Acid | 1986 |
Involvement of bicuculline-insensitive receptors in the hypothermic effect of GABA and its agonists.
Topics: Amino Acids; Amino Acids, Neutral; Animals; Bicuculline; Body Temperature; Drug Interactions; Female; gamma-Aminobutyric Acid; Hypothermia; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Time Factors; Valproic Acid | 1985 |
The effects of beta-carboline carboxylic acid ethyl ester and its free acid, administered ICV, on the anticonvulsant activity of diazepam and sodium valproate in the mouse.
Topics: Animals; Benzodiazepinones; Carbolines; Diazepam; Drug Interactions; Female; Mice; Mice, Inbred C3H; Pentylenetetrazole; Receptors, GABA-A; Seizures; Valproic Acid | 1986 |
Benzodiazepine cross-tolerance in mice extends to sodium valproate.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Clobazam; Clonazepam; Diazepam; Drug Tolerance; Lorazepam; Male; Mice; Pentylenetetrazole; Phenobarbital; Valproic Acid | 1986 |
[Synergic effect of GABA and glycine in the antagonism of convulsions caused by pentetrazole in rats. Study of glycine valproamide].
Topics: Animals; Drug Synergism; gamma-Aminobutyric Acid; Glycine; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures; Valproic Acid | 1986 |
Anticonvulsant potency and neurotoxicity of valproate alone and in combination with carbamazepine or phenobarbital.
Topics: Animals; Brain; Carbamazepine; Drug Interactions; Drug Therapy, Combination; Electroshock; Female; Mice; Mice, Inbred ICR; Neurotoxins; Pentylenetetrazole; Phenobarbital; Seizures; Valproic Acid | 1988 |
Effect of stimulus intensity on the profile of anticonvulsant activity of phenytoin, ethosuximide and valproate.
Topics: Animals; Anticonvulsants; Bicuculline; Electroshock; Ethosuximide; Male; Mice; Pentylenetetrazole; Phenytoin; Picrotoxin; Seizures; Valproic Acid | 1985 |
Spiro[4.5] and spiro[4.6] carboxylic acids: cyclic analogues of valproic acid. Synthesis and anticonvulsant evaluation.
Topics: Animals; Anticonvulsants; Bicuculline; Carboxylic Acids; Male; Mice; Pentylenetetrazole; Picrotoxin; Spiro Compounds; Structure-Activity Relationship; Valproic Acid | 1985 |
A timed intravenous pentylenetetrazol infusion seizure model for quantitating the anticonvulsant effect of valproic acid in the rat.
Topics: Animals; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Infusions, Parenteral; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures; Valproic Acid | 1985 |
An analysis of the in vivo interactions between chemical convulsants and anticonvulsants.
Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Mice; Pentylenetetrazole; Phenobarbital; Picrotoxin; Valproic Acid | 1985 |
Effect of valproate on brain GABA: comparison with various medium chain fatty acids.
Topics: Ammonia; Animals; Anticonvulsants; Brain Chemistry; Fatty Acids; gamma-Aminobutyric Acid; Male; Mice; Pentylenetetrazole; Valproic Acid | 1985 |
Discriminative stimulus properties of valproic acid in the pigeon.
Topics: Animals; Anticonvulsants; Columbidae; Dextroamphetamine; Discrimination Learning; Generalization, Psychological; Imipramine; Morphine; Pentylenetetrazole; Valproic Acid | 1985 |
Evidence that GABA mechanisms mediate the anxiolytic action of benzodiazepines: a study with valproic acid.
Topics: Animals; Anti-Anxiety Agents; Conflict, Psychological; Diazepam; Discrimination Learning; gamma-Aminobutyric Acid; Male; Pentylenetetrazole; Rats; Valproic Acid | 1980 |
[Anticonvulsant action of di-N-propylacetate combined with benzodiazepines, phenobarbital and phenytoin].
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Diazepam; Drug Therapy, Combination; Male; Mice; Pentylenetetrazole; Phenobarbital; Phenytoin; Seizures; Semicarbazides; Valproic Acid | 1981 |
Pharmacologic analysis of sodium valproate-induced suppression of secondary components of visual evoked potentials in albino rats.
Topics: Animals; Benzodiazepinones; Convulsants; Drug Interactions; Evoked Potentials, Visual; Female; gamma-Aminobutyric Acid; Male; Naloxone; Pentylenetetrazole; Photic Stimulation; Picrotoxin; Rats; Synaptic Transmission; Time Factors; Valproic Acid | 1981 |
The role of different types of adrenergic receptors in pentylenetetrazol-induced seizures and the effect of di-n-propylacetate in the rat.
Topics: Animals; Hydroxydopamines; Male; Oxidopamine; Pentylenetetrazole; Piperoxan; Rats; Receptors, Adrenergic; Seizures; Serotonin; Synaptic Transmission; Valproic Acid | 1983 |
DMCM: a potent convulsive benzodiazepine receptor ligand.
Topics: Animals; Carbolines; Convulsants; Diazepam; Drug Interactions; Female; Indoles; Lorazepam; Male; Mice; Pentylenetetrazole; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Seizures; Valproic Acid | 1983 |
Studies on the role of serotonin in different regions of the rat central nervous system on pentylenetetrazol-induced seizures and the effect of di-n-propylacetate.
Topics: 5,7-Dihydroxytryptamine; Animals; Anticonvulsants; Brain; Male; Metergoline; Methysergide; Neurons; Pentylenetetrazole; Rats; Seizures; Serotonin; Spinal Cord; Valproic Acid | 1983 |
The effects of analogues of valproic acid on seizures induced by pentylenetetrazol and GABA content in brain of mice.
Topics: Animals; Anticonvulsants; Brain Chemistry; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred Strains; Pentylenetetrazole; Seizures; Valproic Acid | 1983 |
Comparative evaluation of anticonvulsant and toxic potencies of valproic acid and 2-en-valproic acid in different animal models of epilepsy.
Topics: Animals; Anticonvulsants; Electroshock; Epilepsy; Fatty Acids, Monounsaturated; Fatty Acids, Unsaturated; Female; Gerbillinae; Lethal Dose 50; Male; Mice; Pentylenetetrazole; Pregnancy; Seizures; Species Specificity; Teratogens; Valproic Acid | 1984 |
Anticonvulsant activity of 4,9-dioxo-5,10-diazatetradecane (CM 40142), a new GABA derivative, in mice and photosensitive baboons).
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Behavior, Animal; Bicuculline; Electroshock; Female; gamma-Aminobutyric Acid; Male; Mice; Motor Activity; Papio; Pentylenetetrazole; Photic Stimulation; Seizures; Strychnine; Valproic Acid | 1984 |
Glycine potentiates the action of some anticonvulsant drugs in some seizure models.
Topics: 3-Mercaptopropionic Acid; Acoustic Stimulation; Animals; Anticonvulsants; Disease Models, Animal; Drug Synergism; Glycine; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Pentylenetetrazole; Phenobarbital; Phenytoin; Seizures; Valproic Acid | 1984 |
[Effect of sodium dipropylacetate on experimental convulsions produced by pentetrazole and picrotoxin].
Topics: Animals; Male; Mice; Pentylenetetrazole; Picrotoxin; Seizures; Valproic Acid | 1981 |
Effect of antiepileptic drugs on metrazol convulsions during ontogenesis in the rat.
Topics: Age Factors; Animals; Anticonvulsants; Clonazepam; Ethosuximide; Male; Pentylenetetrazole; Rats; Seizures; Valproic Acid | 1981 |
[Tranquilizing effect of n-dipropylacetate and other GABA-ergic substances in conflict situations].
Topics: Acetates; Aminooxyacetic Acid; Animals; Bicuculline; Caffeine; Conflict, Psychological; Male; Models, Psychological; Pantothenic Acid; Pentylenetetrazole; Piracetam; Pyrrolidinones; Rats; Tranquilizing Agents; Valproic Acid | 1980 |
Anticonvulsant activity of metabolites of valproic acid.
Topics: Animals; Anticonvulsants; Biotransformation; Electroshock; Male; Mice; Pentylenetetrazole; Valproic Acid | 1981 |
Effects of some antiepileptic drugs in pentetrazol-induced convulsions in mice lesioned with kainic acid.
Topics: Acetazolamide; Animals; Anticonvulsants; Carbamazepine; Diazepam; Dose-Response Relationship, Drug; Hippocampus; Injections, Intraventricular; Kainic Acid; Male; Mice; Pentylenetetrazole; Phenobarbital; Pyrrolidines; Seizures; Succinimides; Trimethadione; Valproic Acid | 1981 |
Effects of ethyl ester derivatives of valproic acid metabolites on pentylenetetrazol seizures in mice.
Topics: Animals; Drug Administration Schedule; Male; Mice; Mice, Inbred ICR; Pentylenetetrazole; Seizures; Valproic Acid | 1981 |
Anticonvulsant and antiaggressive properties of di-n-propyl acetate after repeated treatment.
Topics: Acoustic Stimulation; Aggression; Animals; Anticonvulsants; Brain; Female; gamma-Aminobutyric Acid; Humans; Male; Mice; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Seizures; Time Factors; Valproic Acid | 1982 |
The relationship between plasma concentration of valproic acid and its anticonvulsant and behavioural effects in the rat.
Topics: Administration, Oral; Amygdala; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Electroshock; Injections, Intraperitoneal; Kindling, Neurologic; Motor Skills; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures; Valproic Acid | 1982 |
Inhibitory mediation of catecholamines for anticonvulsant activity of sodium valproate.
Topics: Animals; Anticonvulsants; Catecholamines; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Valproic Acid | 1982 |
Withdrawal-like effects of pentylenetetrazol and valproate in the naive organism: a model of motivation produced by opiate withdrawal?
Topics: Animals; Avoidance Learning; Conditioning, Classical; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Morphine Dependence; Motivation; Naloxone; Neurologic Examination; Opioid-Related Disorders; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Taste; Valproic Acid | 1995 |
Distribution of unsaturated metabolites of valproate in human and rat brain--pharmacologic relevance?
Topics: Adolescent; Adult; Aged; Animals; Biological Transport; Blood-Brain Barrier; Brain; Brain Chemistry; Child; Epilepsy; Female; Humans; Male; Middle Aged; Pentylenetetrazole; Protein Binding; Rats; Rats, Sprague-Dawley; Seizures; Tissue Distribution; Valproic Acid | 1995 |
Comparison of anticonvulsant efficacy of valproate during prolonged treatment with one and three daily doses or continuous ("controlled release") administration in a model of generalized seizures in rats.
Topics: Animals; Delayed-Action Preparations; Epilepsy, Generalized; Female; Infusions, Intravenous; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; Time Factors; Valproic Acid | 1995 |
The significance of extracellular GABA in the substantia nigra of the rat during seizures and anticonvulsant treatments.
Topics: Animals; Anticonvulsants; gamma-Aminobutyric Acid; Male; Microdialysis; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; Substantia Nigra; Valproic Acid; Vigabatrin | 1995 |
Valproic acid-induced rapid changes of met-enkephalin levels in rat brain. Probable association with abstinence behavior and anticonvulsant activity.
Topics: Animals; Anticonvulsants; Brain Chemistry; Chromatography, Gel; Chromatography, High Pressure Liquid; Enkephalin, Methionine; Epilepsy, Tonic-Clonic; Injections, Intraperitoneal; Male; Pentylenetetrazole; Rats; Rats, Wistar; Substance Withdrawal Syndrome; Valproic Acid | 1994 |
Is the site of action of ethosuximide in the hindbrain?
Topics: Animals; Anticonvulsants; Brain Stem; Clonazepam; Decerebrate State; Electrocardiography; Electroencephalography; Ethosuximide; Male; Pentylenetetrazole; Rats; Rats, Wistar; Rhombencephalon; Seizures; Valproic Acid | 1994 |
Synthesis and evaluation of amino analogues of valproic acid.
Topics: Animals; Anticonvulsants; Electroshock; Injections, Intraperitoneal; Mice; Pentylenetetrazole; Seizures; Valproic Acid | 1994 |
[The antiepileptic effects of the combined action of the new 1,4-dihydropyridine derivative glutapyrone with sodium valproate and phenobarbital].
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Dihydropyridines; Drug Evaluation, Preclinical; Drug Therapy, Combination; Electroshock; Epilepsies, Partial; Epilepsy, Generalized; Glutamates; Male; Mice; Mice, Inbred ICR; Pentylenetetrazole; Phenobarbital; Rats; Rats, Wistar; Valproic Acid | 1993 |
Anticonvulsant and neurotoxic activities of twelve analogues of valproic acid.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred Strains; Nervous System Diseases; Pentylenetetrazole; Seizures; Structure-Activity Relationship; Valproic Acid | 1993 |
Antiepileptic drugs--their effects on kindled seizures and kindling-induced learning impairments.
Topics: Animals; Anticonvulsants; Avoidance Learning; Cognition; Dose-Response Relationship, Drug; Ethosuximide; Kindling, Neurologic; Learning Disabilities; Male; Pentylenetetrazole; Phenobarbital; Rats; Rats, Wistar; Seizures; Valproic Acid | 1995 |
Influence of nicardipine, nimodipine and flunarizine on the anticonvulsant efficacy of antiepileptics against pentylenetetrazol in mice.
Topics: Animals; Anticonvulsants; Calcium Channel Blockers; Clonazepam; Drug Interactions; Ethosuximide; Flunarizine; Male; Mice; Mice, Inbred Strains; Motor Activity; Nicardipine; Nimodipine; Pentylenetetrazole; Random Allocation; Seizures; Valproic Acid | 1996 |
3-Hydroxymethylphenytoin valproic acid ester, a new prodrug combining two anticonvulsant drugs.
Topics: Animals; Anticonvulsants; Convulsants; Electroshock; Mice; Pentylenetetrazole; Phenytoin; Prodrugs; Rats; Valproic Acid | 1996 |
Anticonvulsant activity of novel derivatives of 2- and 3-piperidinecarboxylic acid in mice and rats.
Topics: 4-Aminopyridine; Amygdala; Animals; Anticonvulsants; Brain; Convulsants; Kindling, Neurologic; Male; Mice; Mice, Inbred Strains; Molecular Structure; N-Methylaspartate; Neurotoxins; Nipecotic Acids; Pentylenetetrazole; Pipecolic Acids; Proline; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Phencyclidine; Seizures; Structure-Activity Relationship; Valproic Acid | 1996 |
Preliminary evaluation of the anticonvulsant activity of a valproic acid analog: N-(2-propylpentanoyl) urea.
Topics: Animals; Anticonvulsants; Bicuculline; Central Nervous System; Convulsants; Dose-Response Relationship, Drug; Electroshock; Lethal Dose 50; Male; Mice; Motor Activity; Pentylenetetrazole; Seizures; Sleep; Strychnine; Time Factors; Urea; Valproic Acid | 1997 |
Additive anticonvulsant effect of flunarizine and sodium valproate on electroshock and chemoshock induced seizures in mice.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Drug Interactions; Drug Synergism; Drug Therapy, Combination; Electroshock; Ethosuximide; Flunarizine; Male; Mice; Motor Activity; Pentylenetetrazole; Phenytoin; Seizures; Valproic Acid | 1998 |
Potent anticonvulsant paeonimetabolin-I derivatives obtained by incubation of paeoniflorin and thiol compounds with Lactobacillus brevis.
Topics: Animals; Anticonvulsants; Benzoates; Bridged-Ring Compounds; Dose-Response Relationship, Drug; Glucosides; Lactobacillus; Male; Mice; Monoterpenes; Pentylenetetrazole; Plants, Medicinal; Seizures; Stereoisomerism; Structure-Activity Relationship; Sulfhydryl Compounds; Valproic Acid | 1998 |
Effect of clobenpropit, a centrally acting histamine H3-receptor antagonist, on electroshock- and pentylenetetrazol-induced seizures in mice.
Topics: Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Differential Threshold; Electroshock; Histamine Antagonists; Imidazoles; Male; Mice; Motor Activity; Pentylenetetrazole; Seizures; Thiourea; Valproic Acid | 1998 |
Effects of new valproate derivatives on epileptiform discharges induced by pentylenetetrazole or low Mg2+ in rat entorhinal cortex-hippocampus slices.
Topics: Animals; Anticonvulsants; Convulsants; Entorhinal Cortex; Epilepsy; Female; Glucose; Hippocampus; In Vitro Techniques; Magnesium; Male; Pentylenetetrazole; Rats; Rats, Wistar; Structure-Activity Relationship; Valproic Acid; Xylitol | 1998 |
N(G)-nitro-L-arginine impairs the anticonvulsive action of ethosuximide against pentylenetetrazol.
Topics: Animals; Anticonvulsants; Arginine; Convulsants; Diazepam; Drug Interactions; Enzyme Inhibitors; Ethosuximide; Male; Mice; Nitroarginine; Pentylenetetrazole; Phenobarbital; Psychomotor Performance; Seizures; Valproic Acid | 1999 |
Effect of theophylline on diazepam and sodium valproate protection in pentylenetetrazole - kindled seizures in rats.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Drug Interactions; Male; Pentylenetetrazole; Protective Agents; Rats; Rats, Wistar; Seizures; Theophylline; Valproic Acid | 1997 |
Effect of sodium valproate and flunarizine administered alone and in combination on pentylenetetrazole model of absence seizures in rat.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Drug Synergism; Electroencephalography; Epilepsy, Absence; Flunarizine; Male; Pentylenetetrazole; Rats; Rats, Wistar; Valproic Acid | 1999 |
Anticonvulsant profile of nimodipine and nitrendipine against pentylenetetrazole induced seizures in rats.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Male; Nimodipine; Nitrendipine; Pentylenetetrazole; Rats; Seizures; Valproic Acid | 1999 |
Acute and chronic effects of the synthetic neuroactive steroid, ganaxolone, against the convulsive and lethal effects of pentylenetetrazol in seizure-kindled mice: comparison with diazepam and valproate.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Dose-Response Relationship, Drug; Kindling, Neurologic; Male; Mice; Motor Activity; Pentylenetetrazole; Pregnanolone; Seizures; Stereotypic Movement Disorder; Valproic Acid | 2000 |
Enhanced anticonvulsant activity of ganaxolone after neurosteroid withdrawal in a rat model of catamenial epilepsy.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Disease Models, Animal; Enzyme Inhibitors; Epilepsy; Female; Finasteride; Menstruation; Oxidoreductases; Pentylenetetrazole; Pregnanolone; Pseudopregnancy; Rats; Rats, Sprague-Dawley; Seizures; Steroids; Valproic Acid | 2000 |
4-Hydroxybenzaldehyde from Gastrodia elata B1. is active in the antioxidation and GABAergic neuromodulation of the rat brain.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Benzaldehydes; Brain; Convulsants; gamma-Aminobutyric Acid; Lipid Peroxidation; Male; Neurotransmitter Agents; Pentylenetetrazole; Plants, Medicinal; Rats; Rats, Sprague-Dawley; Seizures; Valproic Acid | 2000 |
Comparative profiles of sodium valproate and ethosuximide on electro-behavioural correlates in gamma-hydroxybutyrate and pentylenetetrazol induced absence seizures in rats.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Electroencephalography; Epilepsy, Absence; Ethosuximide; Male; Pentylenetetrazole; Rats; Rats, Wistar; Sodium Oxybate; Species Specificity; Valproic Acid | 2000 |
Enhanced anticonvulsant activity of neuroactive steroids in a rat model of catamenial epilepsy.
Topics: Allosteric Regulation; Animals; Anticonvulsants; Benzodiazepinones; Desoxycorticosterone; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy; Female; Menstrual Cycle; Pentylenetetrazole; Phenobarbital; Pregnanolone; Pseudopregnancy; Rats; Rats, Sprague-Dawley; Receptors, GABA; Steroids; Substance Withdrawal Syndrome; Valproic Acid | 2001 |
Synthesis of valproic acid amides of a melatonin derivative, a piracetam and amantadine for biological tests.
Topics: Amantadine; Animals; Melatonin; Pentylenetetrazole; Piracetam; Rodentia; Seizures; Valproic Acid | 2001 |
Comparison of the anticonvulsant efficacies and neurotoxic effects of valproic acid, phenytoin, and the ketogenic diet.
Topics: 3-Hydroxybutyric Acid; Animals; Anticonvulsants; Dietary Fats; Electroencephalography; Energy Intake; Male; Pentylenetetrazole; Phenytoin; Rats; Rats, Sprague-Dawley; Seizures; Treatment Outcome; Valproic Acid | 2001 |
Aspirin modulates the anticonvulsant effect of diazepam and sodium valproate in pentylenetetrazole and maximal electroshock induced seizures in mice.
Topics: Animals; Anticonvulsants; Aspirin; Diazepam; Male; Mice; Pentylenetetrazole; Prostaglandins; Seizures; Valproic Acid | 2001 |
Molsidomine enhances the protective activity of valproate against pentylenetetrazole-induced seizures in mice.
Topics: Animals; Anticonvulsants; Convulsants; Drug Synergism; Male; Mice; Molsidomine; Pentylenetetrazole; Seizures; Valproic Acid; Vasodilator Agents | 2002 |
Interaction of the neurosteroid alphaxalone with conventional antiepileptic drugs in different types of experimental seizures.
Topics: Aminophylline; Amygdala; Anesthetics; Animals; Anticonvulsants; Avoidance Learning; Convulsants; Drug Interactions; Electroshock; Kindling, Neurologic; Male; Memory Disorders; Mice; Movement Disorders; Pentylenetetrazole; Postural Balance; Pregnanediones; Rats; Rats, Wistar; Seizures; Valproic Acid | 2002 |
Synergistic interaction between valproate and lamotrigine against seizures induced by 4-aminopyridine and pentylenetetrazole in mice.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Lamotrigine; Male; Mice; Pentylenetetrazole; Seizures; Triazines; Valproic Acid | 2002 |
Is the interaction between felbamate and valproate against seizures induced by 4-aminopyridine and pentylenetetrazole in mice beneficial?
Topics: 4-Aminopyridine; Analysis of Variance; Animals; Brain; Chromatography, Liquid; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Felbamate; gamma-Aminobutyric Acid; Glutamic Acid; Male; Mice; Mice, Inbred Strains; Neurotoxicity Syndromes; Pentylenetetrazole; Phenylcarbamates; Propylene Glycols; Reaction Time; Seizures; Toxicity Tests; Valproic Acid | 2003 |
Dynamic release of amino acid transmitters induced by valproate in PTZ-kindled epileptic rat hippocampus.
Topics: Amino Acid Transport Systems; Amino Acids; Animals; Anticonvulsants; Epilepsy; Hippocampus; Kindling, Neurologic; Male; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Valproic Acid | 2004 |
Effect of valproic acid on levels of GABA and glutamic acid in pentylenetetrazole-damaged rat brain.
Topics: Animals; Anticonvulsants; Body Weight; Brain Chemistry; Convulsants; gamma-Aminobutyric Acid; Glutamic Acid; Male; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; Valproic Acid | 2003 |
Valproic acid-hydrophilic cyclodextrin complexes and valproic acid-solid dispersions: evaluation of their potential pharmaceutical use.
Topics: Algorithms; Animals; Anticonvulsants; Calorimetry, Differential Scanning; Chromatography, High Pressure Liquid; Convulsants; Cyclodextrins; Drug Carriers; Excipients; Female; Magnetic Resonance Spectroscopy; Male; Pentylenetetrazole; Polyethylene Glycols; Povidone; Rats; Rats, Sprague-Dawley; Seizures; Solubility; Spectrophotometry, Ultraviolet; Valproic Acid | 2004 |
Metabolism of a new antiepileptic drug, N-methyl-tetramethylcyclopropanecarboxamide, and anticonvulsant activity of its metabolites.
Topics: Amides; Animals; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Behavior, Animal; Biotransformation; Brain; Brain Chemistry; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Cyclopropanes; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP2C19; Dose-Response Relationship, Drug; Electroshock; Gas Chromatography-Mass Spectrometry; Humans; Hydroxylation; In Vitro Techniques; Male; Mice; Microsomes, Liver; Mixed Function Oxygenases; Pentylenetetrazole; Seizures; Valproic Acid | 2004 |
Tetramethylcyclopropyl analogue of a leading antiepileptic drug, valproic acid. Synthesis and evaluation of anticonvulsant activity of its amide derivatives.
Topics: Animals; Anticonvulsants; Convulsants; Cyclopropanes; Electroshock; Mice; Pentylenetetrazole; Polyunsaturated Alkamides; Rats; Seizures; Species Specificity; Structure-Activity Relationship; Urea; Valproic Acid | 2004 |
Isobolographic and subthreshold analysis of interactions among felbamate and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice.
Topics: Animals; Anticonvulsants; Behavior, Animal; Clonazepam; Disease Models, Animal; Drug Interactions; Drug Synergism; Drug Therapy, Combination; Epilepsies, Myoclonic; Ethosuximide; Felbamate; Female; Humans; Lethal Dose 50; Mice; Motor Activity; Neurotoxicity Syndromes; Pentylenetetrazole; Phenobarbital; Phenylcarbamates; Propylene Glycols; Seizures; Valproic Acid | 2004 |
Ethosuximide and valproate display high efficacy against lindane-induced seizures in mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Ethosuximide; GABA Agents; Hexachlorocyclohexane; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Mice; Pentylenetetrazole; Seizures; Valproic Acid | 2004 |
Evaluation of the effects of lamotrigine, valproate and carbamazepine in a rodent model of mania.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Bipolar Disorder; Carbamazepine; Central Nervous System Stimulants; Chlordiazepoxide; Dextroamphetamine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation; Drug Interactions; Drug Therapy, Combination; Lamotrigine; Mice; Motor Activity; Pentylenetetrazole; Psychomotor Agitation; Seizures; Triazines; Valproic Acid | 2005 |
Beneficial interaction between vigabatrin and valproate against seizures induced by pentylenetetrazole in mice.
Topics: Animals; Anticonvulsants; Brain; Convulsants; Drug Synergism; gamma-Aminobutyric Acid; Glutamic Acid; Male; Mice; Pentylenetetrazole; Valproic Acid; Vigabatrin | 2005 |
Antiepileptogenic and antioxidant effects of Nigella sativa oil against pentylenetetrazol-induced kindling in mice.
Topics: Adenosine Deaminase; Analysis of Variance; Animals; Anticonvulsants; Antioxidants; Dose-Response Relationship, Drug; Drug Interactions; Glutathione Peroxidase; Kindling, Neurologic; Male; Malondialdehyde; Mice; Nitric Oxide; Pentylenetetrazole; Plant Oils; Seizures; Time Factors; Valproic Acid; Xanthine Oxidase | 2005 |
Pharmacodynamic and/or pharmacokinetic characteristics of interactions between loreclezole and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice: an isobolographic analysis.
Topics: Animals; Anticonvulsants; Clonazepam; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Ethosuximide; Kindling, Neurologic; Linear Models; Male; Mice; Pentylenetetrazole; Phenobarbital; Seizures; Triazoles; Valproic Acid | 2005 |
Preclinical profiling and safety studies of ABT-769: a compound with potential for broad-spectrum antiepileptic activity.
Topics: Abnormalities, Drug-Induced; Amygdala; Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Drug Evaluation, Preclinical; Electroshock; Epilepsy; Epilepsy, Absence; Humans; Injections, Intravenous; Injections, Subcutaneous; Kindling, Neurologic; Male; Mice; Mitochondria, Liver; Pentylenetetrazole; Rats; Rats, Wistar; Species Specificity; Spiro Compounds; Valproic Acid | 2005 |
An experimental evaluation of anticonvulsant activity of Vitex-negundo.
Topics: Animals; Anticonvulsants; Drug Combinations; Drug Evaluation, Preclinical; Drug Interactions; Electroshock; Male; Pentylenetetrazole; Phenytoin; Phytotherapy; Plant Extracts; Plant Leaves; Plants, Medicinal; Rats; Rats, Wistar; Reference Standards; Seizures; Valproic Acid; Vitex | 2005 |
Absence of convulsive liability of doripenem, a new carbapenem antibiotic, in comparison with beta-lactam antibiotics.
Topics: Alanine; Animals; Anti-Bacterial Agents; Anticonvulsants; Carbapenems; Convulsants; Dogs; Doripenem; Drug Interactions; Electroencephalography; Injections, Intravenous; Injections, Intraventricular; Male; Meropenem; Mice; Mice, Inbred ICR; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; Thienamycins; Valproic Acid | 2006 |
Modulation of pentylenetetrazole-induced seizures and oxidative stress parameters by sodium valproate in the absence and presence of N-acetylcysteine.
Topics: Acetylcysteine; Alanine Transaminase; Animals; Anticonvulsants; Antioxidants; Aspartate Aminotransferases; Brain; Disease Models, Animal; Drug Therapy, Combination; Glutathione; Kidney; Liver; Mice; Oxidative Stress; Pentylenetetrazole; Seizures; Thiobarbituric Acid Reactive Substances; Valproic Acid | 2006 |
Pentylenetetrazol-induced kindling seizure attenuated by Ginkgo biloba extract (EGb 761) in mice.
Topics: Animals; Anticonvulsants; Brain; Brain Injuries; Convulsants; Ginkgo biloba; Housing, Animal; Kindling, Neurologic; Male; Mice; Models, Animal; Pentylenetetrazole; Plant Extracts; Reference Values; Valproic Acid | 2006 |
Characterization of the anticonvulsant, behavioral and pharmacokinetic interaction profiles of stiripentol in combination with clonazepam, ethosuximide, phenobarbital, and valproate using isobolographic analysis.
Topics: Animals; Anticonvulsants; Brain Chemistry; Clonazepam; Dioxolanes; Disease Models, Animal; Drug Interactions; Drug Therapy, Combination; Ethosuximide; Male; Mice; Neurotoxicity Syndromes; Pentylenetetrazole; Phenobarbital; Seizures; Valproic Acid | 2006 |
Thalidomide inhibits pentylenetetrazole-induced seizures.
Topics: Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Ethosuximide; Male; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; Severity of Illness Index; Valproic Acid | 2007 |
Crystal structure and anticonvulsant activity of (+/-)-1,2:4,5-di-O-isopropylidene-3,6-di-O-(2-propylpentanoyl)-myo-inositol.
Topics: Animals; Anticonvulsants; Carbohydrate Conformation; Crystallography, X-Ray; Electroshock; Inositol; Mice; Pentylenetetrazole; Valproic Acid | 2007 |
Anticonvulsant profile and teratogenicity of 3,3-dimethylbutanoylurea: a potential for a second generation drug to valproic acid.
Topics: Animals; Anticonvulsants; Behavior, Animal; Electrodes, Implanted; Half-Life; Hippocampus; Kindling, Neurologic; Male; Mice; Neural Tube Defects; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Teratogens; Urea; Valproic Acid | 2008 |
Increase in antiepileptic efficacy during prolonged treatment with valproic acid: role of inhibition of histone deacetylases?
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy, Generalized; Female; Histone Deacetylases; Hydroxamic Acids; Mice; Pentylenetetrazole; Protein Synthesis Inhibitors; Time Factors; Valproic Acid | 2008 |
Dose-finding study with nicotine as a proconvulsant agent in PTZ-induced seizure model in mice.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Fructose; Ganglionic Stimulants; Male; Mice; Nicotine; Pentylenetetrazole; Seizures; Topiramate; Valproic Acid | 2008 |
Synthesis and anticonvulsant evaluation of 6-amino-1,4-oxazepane-3,5-dione derivatives.
Topics: Animals; Anticonvulsants; Convulsants; Electroshock; Indicators and Reagents; Male; Mice; Mice, Inbred ICR; Oxazepines; Pentylenetetrazole; Valproic Acid | 2008 |
Interaction of tiagabine with valproate in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis for non-parallel dose-response relationship curves.
Topics: Animals; Anticonvulsants; Brain Chemistry; Convulsants; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Epilepsy; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Mice; Nipecotic Acids; Pentylenetetrazole; Random Allocation; Seizures; Tiagabine; Valproic Acid | 2009 |
Isobolographic characterization of the anticonvulsant interaction profiles of levetiracetam in combination with clonazepam, ethosuximide, phenobarbital and valproate in the mouse pentylenetetrazole-induced seizure model.
Topics: Animals; Anticonvulsants; Clonazepam; Convulsants; Disease Models, Animal; Drug Interactions; Drug Therapy, Combination; Ethosuximide; Levetiracetam; Male; Mice; Pentylenetetrazole; Phenobarbital; Piracetam; Seizures; Valproic Acid | 2009 |
Evaluation of stereoselective anticonvulsant, teratogenic, and pharmacokinetic profile of valnoctylurea (capuride): a chiral stereoisomer of valproic acid urea derivative.
Topics: Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Female; Half-Life; Male; Mice; Neural Tube Defects; Pentanoic Acids; Pentylenetetrazole; Pregnancy; Rats; Rats, Sprague-Dawley; Seizures; Stereoisomerism; Structure-Activity Relationship; Teratogens; Urea; Valproic Acid | 2010 |
Anticonvulsant profile and teratogenic evaluation of potent new analogues of a valproic acid urea derivative in NMRI mice.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Bone and Bones; Deep Sedation; Differential Threshold; Electric Stimulation; Electroshock; Female; Fetal Death; Mice; Mice, Inbred Strains; Motor Activity; Neural Tube Defects; Pentylenetetrazole; Pregnancy; Rats; Rats, Sprague-Dawley; Seizures; Structure-Activity Relationship; Teratogens; Urea; Valproic Acid | 2009 |
Synthesis and evaluation of antiallodynic and anticonvulsant activity of novel amide and urea derivatives of valproic acid analogues.
Topics: Amides; Animals; Anticonvulsants; Electroshock; Isomerism; Male; Mice; Pain; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Seizures; Spinal Nerves; Urea; Valproic Acid | 2009 |
Antiepileptogenic and anticonvulsive actions of levetiracetam in a pentylenetetrazole kindling model.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Injections, Intraperitoneal; Kindling, Neurologic; Levetiracetam; Male; Mice; Mice, Inbred Strains; Pentylenetetrazole; Piracetam; Seizures; Treatment Outcome; Valproic Acid | 2010 |
Magnesium supplementation enhances the anticonvulsant potential of valproate in pentylenetetrazol-treated rats.
Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Drug Synergism; gamma-Aminobutyric Acid; Glutathione; Lipid Peroxidation; Magnesium; Male; Nitric Oxide; Pentylenetetrazole; Rats; Rats, Wistar; Reaction Time; Seizures; Statistics, Nonparametric; Valproic Acid | 2010 |
Levetiracetam in submaximal subcutaneous pentylentetrazol-induced seizures in rats.
Topics: Animals; Anticonvulsants; Convulsants; Dose-Response Relationship, Drug; Electroshock; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; Injections, Subcutaneous; Levetiracetam; Male; Pentylenetetrazole; Piracetam; Rats; Rats, Wistar; Seizures; Valproic Acid | 2010 |
Synthesis and anticonvulsant activity of 4-oxo and 4-thioxo-8-bromobenzopyran derivatives.
Topics: Animals; Anticonvulsants; Benzopyrans; Electroshock; Indicators and Reagents; Lethal Dose 50; Male; Mice; Nervous System Diseases; Pentylenetetrazole; Phenytoin; Seizures; Stereoisomerism; Structure-Activity Relationship; Valproic Acid | 2010 |
An experimental study of the anticonvulsant effect of amlodipine in mice.
Topics: Amlodipine; Animals; Anticonvulsants; Calcium Channel Blockers; Convulsants; Disease Models, Animal; Electroshock; Female; Male; Mice; Mice, Inbred Strains; Pentylenetetrazole; Seizures; Time Factors; Valproic Acid | 2010 |
Anticonvulsant potential of the peroxisome proliferator-activated receptor γ agonist pioglitazone in pentylenetetrazole-induced acute seizures and kindling in mice.
Topics: Animals; Anticonvulsants; Kindling, Neurologic; Male; Mice; Pentylenetetrazole; Pioglitazone; PPAR gamma; Seizures; Thiazolidinediones; Valproic Acid | 2010 |
Improvement of pentylenetetrazol-induced learning deficits by valproic acid in the adult zebrafish.
Topics: Animals; Anticonvulsants; Avoidance Learning; Behavior, Animal; Brain; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Dyskinesia, Drug-Induced; Gene Expression Regulation; HSP70 Heat-Shock Proteins; Learning Disabilities; Locomotion; Muscarinic Antagonists; Neuroprotective Agents; Pentylenetetrazole; RNA, Messenger; Scopolamine; Seizures; Time Factors; Valproic Acid; Zebrafish | 2010 |
Comparative pharmacodynamic and pharmacokinetic analysis of two anticonvulsant halo derivatives of 2,2,3,3-tetramethylcyclopropanecarboxamide, an amide of a cyclic analog of valproic acid.
Topics: Abnormalities, Drug-Induced; Amides; Analgesics; Animals; Anticonvulsants; Cyclopropanes; Disease Models, Animal; Epilepsy; Humans; Mice; Neural Tube Defects; Pain; Pentylenetetrazole; Rats; Valproic Acid | 2010 |
[Effect of Chaihu Shugan Tang on excitability in different brain regions of pentylenetetrazole-kindled chronic epileptic rats].
Topics: 4-Chloro-7-nitrobenzofurazan; Animals; Aspartic Acid; Brain; Chronic Disease; Deoxyglucose; Disease Models, Animal; Drugs, Chinese Herbal; Epilepsy; Glutamic Acid; Hippocampus; Humans; Kindling, Neurologic; Male; Pentylenetetrazole; Random Allocation; Rats; Valproic Acid | 2010 |
Prevention of sodium valproate-induced hepatotoxicity by curcumin, rosiglitazone and N-acetylcysteine in rats.
Topics: Acetylcysteine; Animals; Anticonvulsants; Body Weight; Chemical and Drug Induced Liver Injury; Convulsants; Curcumin; Eating; Fatty Liver; Free Radical Scavengers; Hypoglycemic Agents; Liver; Liver Function Tests; Male; Mice; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Rosiglitazone; Seizures; Thiazolidinediones; Valproic Acid | 2010 |
Anticonvulsant activity of BmK AS, a sodium channel site 4-specific modulator.
Topics: Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Cells, Cultured; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Embryo, Mammalian; Exploratory Behavior; Male; Membrane Potentials; Motor Activity; Neurons; Patch-Clamp Techniques; Pentylenetetrazole; Peptides; Pilocarpine; Rats; Rats, Sprague-Dawley; Reaction Time; Scorpion Venoms; Seizures; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin; Valproic Acid | 2011 |
Study of epileptiform activity in cerebral ganglion of mud crab Scylla serrata.
Topics: Animals; Anticonvulsants; Brachyura; Convulsants; Disease Models, Animal; Epilepsy; gamma-Aminobutyric Acid; Ganglia, Invertebrate; Glutamic Acid; Neurons; Pentylenetetrazole; Valproic Acid | 2011 |
Effects of WIN 55,212-2 mesylate (a synthetic cannabinoid) on the protective action of clonazepam, ethosuximide, phenobarbital and valproate against pentylenetetrazole-induced clonic seizures in mice.
Topics: Animals; Anticonvulsants; Avoidance Learning; Benzoxazines; Brain; Cannabinoid Receptor Agonists; Clonazepam; Disease Models, Animal; Drug Synergism; Ethosuximide; Hand Strength; Male; Mice; Morpholines; Naphthalenes; Pentylenetetrazole; Phenobarbital; Seizures; Valproic Acid | 2011 |
Design and pharmacological activity of glycinamide and N-methoxy amide derivatives of analogs and constitutional isomers of valproic acid.
Topics: Amides; Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Electroshock; Female; Isomerism; Male; Mice; Neural Tube Defects; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Seizures; Structure-Activity Relationship; Valproic Acid | 2011 |
Synthesis and anticonvulsant evaluation of dimethylethanolamine analogues of valproic acid and its tetramethylcyclopropyl analogue.
Topics: Animals; Anticonvulsants; Brain Waves; Convulsants; Cyclopropanes; Deanol; Disease Models, Animal; Electroencephalography; Electroshock; Epilepsy; Hippocampus; Kindling, Neurologic; Male; Mice; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Valproic Acid | 2012 |
The antiepileptic effect of sodium valproate during different phases of the estrous cycle in PTZ-induced seizures in rats.
Topics: Animals; Anticonvulsants; Estrous Cycle; Female; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; Valproic Acid | 2012 |
Interaction of hydroalcoholic extract of Acorus calamus Linn. with sodium valproate and carbamazepine.
Topics: Acorus; Animals; Anticonvulsants; Carbamazepine; Convulsants; Dose-Response Relationship, Drug; Drug Interactions; Drug Synergism; Male; Pentylenetetrazole; Phytotherapy; Plant Extracts; Rats; Rats, Wistar; Seizures; Tissue Distribution; Valproic Acid | 2012 |
Kynurenic acid: a new effector of valproate action?
Topics: Animals; Anticonvulsants; Hippocampus; Kindling, Neurologic; Kynurenic Acid; Male; Neurons; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; Valproic Acid | 2011 |
Anticonvulsant activity of bisabolene sesquiterpenoids of Curcuma longa in zebrafish and mouse seizure models.
Topics: Analysis of Variance; Animals; Animals, Genetically Modified; Anticonvulsants; Chromatography, High Pressure Liquid; Convulsants; Curcuma; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Electroencephalography; Green Fluorescent Proteins; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Mice; Mice, Inbred C57BL; Movement; Pentylenetetrazole; Phytotherapy; Plant Extracts; Seizures; Valproic Acid; Zebrafish | 2012 |
Influence of calcium channel blockers on anticonvulsant and antinociceptive activities of valproic acid in pentylenetetrazole-kindled mice.
Topics: Analgesics; Animals; Anticonvulsants; Calcium Channel Blockers; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Injections, Intraperitoneal; Kindling, Neurologic; Male; Mice; Pain; Pain Measurement; Pain Threshold; Pentylenetetrazole; Seizures; Valproic Acid | 2012 |
Closed-loop neural stimulation for pentylenetetrazole-induced seizures in zebrafish.
Topics: Animals; Anticonvulsants; Brain Stem; Convulsants; Disease Models, Animal; Electric Stimulation Therapy; Female; Humans; Pentylenetetrazole; Prosencephalon; Rhombencephalon; Seizures; Vagus Nerve; Valproic Acid; Zebrafish | 2013 |
The role of ethanol on the anticonvulsant effect of valproic acid and cortical microvascular changes after epileptogenesis in mice.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Cerebrovascular Circulation; Drug Synergism; Drug Therapy, Combination; Epilepsy; Ethanol; Male; Mice; Mice, Inbred BALB C; Microvessels; Pentylenetetrazole; Valproic Acid | 2013 |
Evaluation of the possible epileptogenic activity of ciprofloxacin: the role of Nigella sativa on amino acids neurotransmitters.
Topics: Amino Acids; Animals; Anti-Bacterial Agents; Anticonvulsants; Antioxidants; Brain Chemistry; Chromatography, High Pressure Liquid; Ciprofloxacin; Convulsants; Epilepsy; Male; Neurotransmitter Agents; Nigella sativa; Pentylenetetrazole; Plant Extracts; Rats; Valproic Acid | 2013 |
Seizure control by ketogenic diet-associated medium chain fatty acids.
Topics: Animals; Anticonvulsants; Caprylates; Cell Line; Chemical and Drug Induced Liver Injury; Convulsants; Diet, Ketogenic; Dose-Response Relationship, Drug; Drug Resistance; Fatty Acids; Histone Deacetylases; Humans; Hypnotics and Sedatives; Male; Pentylenetetrazole; Pheromones; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus; Valproic Acid | 2013 |
Antiepileptic drugs prevent changes in adenosine deamination during acute seizure episodes in adult zebrafish.
Topics: Adenine Nucleotides; Adenosine; Adenosine Deaminase; Amines; Animals; Anticonvulsants; Brain; Cyclohexanecarboxylic Acids; Disease Models, Animal; Female; Gabapentin; gamma-Aminobutyric Acid; Gene Expression; Male; Pentylenetetrazole; Phenytoin; Seizures; Valproic Acid; Zebrafish | 2013 |
ML297 (VU0456810), the first potent and selective activator of the GIRK potassium channel, displays antiepileptic properties in mice.
Topics: Animals; Anticonvulsants; Calcium Signaling; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Electroshock; G Protein-Coupled Inwardly-Rectifying Potassium Channels; HEK293 Cells; High-Throughput Screening Assays; Humans; Injections, Intraperitoneal; Mice; Microsomes, Liver; Molecular Structure; Patch-Clamp Techniques; Pentylenetetrazole; Phenylurea Compounds; Pyrazoles; Rats; Receptors, Metabotropic Glutamate; Recombinant Proteins; Seizures; Valproic Acid | 2013 |
Derivatives of valproic acid are active against pentetrazol-induced seizures in immature rats.
Topics: Aging; Allylisopropylacetamide; Amides; Animals; Anticonvulsants; Convulsants; Epilepsy, Generalized; Male; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; Stereoisomerism; Valproic Acid | 2013 |
Seizure-induced reduction in PIP3 levels contributes to seizure-activity and is rescued by valproic acid.
Topics: Animals; Anticonvulsants; Cells, Cultured; GABA Antagonists; Hippocampus; Kainic Acid; Male; Neurons; Pentylenetetrazole; Phosphatidylinositol Phosphates; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Status Epilepticus; Valproic Acid | 2014 |
Evaluation of anti-epileptic property of Marsilea quadrifolia Linn. in maximal electroshock and pentylenetetrazole-induced rat models of epilepsy.
Topics: Animals; Convulsants; Disease Models, Animal; Electroshock; Epilepsy; Male; Marsileaceae; Pentylenetetrazole; Phytotherapy; Plant Preparations; Rats; Rats, Wistar; Seizures; Treatment Outcome; Valproic Acid | 2013 |
[Combined blockade of AMPA- and NMDA-receptors has maximum effect to eliminate development of pentylenetetrazole-induced kindling in rats].
Topics: Adamantane; Administration, Oral; Animals; Anticonvulsants; Drug Administration Schedule; Male; Pentylenetetrazole; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Cholinergic; Receptors, N-Methyl-D-Aspartate; Seizures; Severity of Illness Index; Valproic Acid | 2013 |
Characterization of a lamotrigine-resistant kindled model of epilepsy in mice: evaluation of drug resistance mechanisms.
Topics: Animals; Anticonvulsants; Calcium Channels; Carbamazepine; Disease Models, Animal; Drug Resistance; Epilepsy; Kindling, Neurologic; Lamotrigine; Male; Mice; Pentylenetetrazole; Time Factors; Triazines; Valproic Acid; Voltage-Gated Sodium Channels | 2014 |
Valproate-induced liver injury: modulation by the omega-3 fatty acid DHA proposes a novel anticonvulsant regimen.
Topics: Administration, Oral; Animals; Anticonvulsants; Chemical and Drug Induced Liver Injury; Docosahexaenoic Acids; Dose-Response Relationship, Drug; Male; Mice; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Valproic Acid | 2014 |
Effect of quercetin and rutin in some acute seizure models in mice.
Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Electric Stimulation; Levetiracetam; Male; Memory, Long-Term; Mice; Muscle Strength; Pentylenetetrazole; Piracetam; Psychomotor Performance; Quercetin; Rutin; Seizures; Time Factors; Valproic Acid | 2014 |
Synthesis, physicochemical, and anticonvulsant properties of new N-Mannich bases derived from pyrrolidine-2,5-dione and its 3-methyl analog.
Topics: Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Electroshock; Ethosuximide; Male; Mannich Bases; Mice; Molecular Structure; Motor Activity; Neurotoxicity Syndromes; Pentylenetetrazole; Pyrrolidines; Rotarod Performance Test; Seizures; Structure-Activity Relationship; Valproic Acid | 2014 |
Degeneration and regeneration of GABAergic interneurons in the dentate gyrus of adult mice in experimental models of epilepsy.
Topics: Animals; Chronic Disease; Dentate Gyrus; Epilepsy; GABAergic Neurons; Glutamate Decarboxylase; Green Fluorescent Proteins; Interneurons; Kindling, Neurologic; Lithium Compounds; Male; Mice, Transgenic; Nerve Degeneration; Nerve Regeneration; Neural Stem Cells; Neurogenesis; Pentylenetetrazole; Pilocarpine; Status Epilepticus; Valproic Acid | 2015 |
[Stimulation of gastric mucosa afferents by phenylephrine potentiates anticonvulsive and eliminates sedative action of sodium valproate in the pentylenetetrazol kindling model in rats].
Topics: Afferent Pathways; Animals; Anticonvulsants; Behavior, Animal; Dose-Response Relationship, Drug; Drug Interactions; Gastric Mucosa; Kindling, Neurologic; Male; Motor Activity; Pentylenetetrazole; Phenylephrine; Rats; Rats, Wistar; Seizures; Sympathomimetics; Valproic Acid; Wakefulness | 2014 |
Valproate-induced neurodevelopmental deficits in Xenopus laevis tadpoles.
Topics: Animals; Animals, Genetically Modified; Anticonvulsants; Avoidance Learning; Convulsants; Dendrites; Developmental Disabilities; Disease Models, Animal; Escape Reaction; Excitatory Amino Acid Agonists; Habituation, Psychophysiologic; Inhibitory Postsynaptic Potentials; Pentylenetetrazole; Reflex, Startle; Retinal Ganglion Cells; Seizures; Superior Colliculi; Valproic Acid; Vision Disorders; Xenopus laevis | 2015 |
Synergistic effect of docosahexaenoic acid on anticonvulsant activity of valproic acid and lamotrigine in animal seizure models.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Docosahexaenoic Acids; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Electroshock; Epilepsy; Kindling, Neurologic; Lamotrigine; Male; Mice; Pentylenetetrazole; Phenytoin; Rats; Rats, Wistar; Seizures; Triazines; Valproic Acid | 2015 |
1-Triacontanol cerotate; isolated from Marsilea quadrifolia Linn. ameliorates reactive oxidative damage in the frontal cortex and hippocampus of chronic epileptic rats.
Topics: Animals; Chronic Disease; Dose-Response Relationship, Drug; Epilepsy, Generalized; Fatty Alcohols; Frontal Lobe; Glutathione; Hippocampus; Malondialdehyde; Marsileaceae; Oxidative Stress; Pentylenetetrazole; Rats; Valproic Acid | 2015 |
Ketogenic diet prevents epileptogenesis and disease progression in adult mice and rats.
Topics: Adenosine; Animals; Anticonvulsants; Diet, Ketogenic; Disease Models, Animal; Disease Progression; DNA Methylation; Hippocampus; Kindling, Neurologic; Male; Mice; Pentylenetetrazole; Pilocarpine; Random Allocation; Rats, Wistar; Seizures; Status Epilepticus; Valproic Acid | 2015 |
Drug screening: zebrafish as a tool for studying epileptic-related chemical compounds.
Topics: Animals; Anticonvulsants; Drug Evaluation, Preclinical; GABA-A Receptor Antagonists; Motor Activity; Pentylenetetrazole; Valproic Acid; Zebrafish | 2015 |
Interactions between an antidepressant reboxetine and four classic antiepileptic drugs in the mouse model of myoclonic seizures.
Topics: Animals; Anticonvulsants; Antidepressive Agents; Avoidance Learning; Clonazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Epilepsies, Myoclonic; Ethosuximide; Male; Mice; Morpholines; Motor Skills; Pentylenetetrazole; Phenobarbital; Reboxetine; Valproic Acid | 2015 |
Modulation of brain glutamate dehydrogenase as a tool for controlling seizures.
Topics: Animals; Anticonvulsants; Brain; Deamination; Diazepam; Disease Models, Animal; Enzyme Inhibitors; Glutamate Dehydrogenase; Glutamic Acid; Ketoglutaric Acids; Male; Mice; Oxidation-Reduction; Oxygen Consumption; Pentylenetetrazole; Phenytoin; Seizures; Time Factors; Valproic Acid | 2015 |
Antiepileptic Activity of a New Derivative of Benzimidazole RU-1205.
Topics: Animals; Anticonvulsants; Benzimidazoles; Kindling, Neurologic; Male; Mice; Morpholines; Pentylenetetrazole; Seizures; Valproic Acid | 2016 |
Anticonvulsant Effects of Combined Treatment with Citicoline and Valproate on the Model of Acute Generalized Convulsions Induced by Pentylenetetrazole in Wistar Rats.
Topics: Animals; Anticonvulsants; Cytidine Diphosphate Choline; Disease Models, Animal; Drug Therapy, Combination; Male; Nootropic Agents; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; Valproic Acid | 2016 |
Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Resistance; Epilepsy; GABA Antagonists; Levetiracetam; Male; Mice; Pentylenetetrazole; Phenobarbital; Pilocarpine; Piracetam; Rats; Seizures; Status Epilepticus; Valproic Acid | 2016 |
Reversal of pentylenetetrazole-altered swimming and neural activity-regulated gene expression in zebrafish larvae by valproic acid and valerian extract.
Topics: Animals; Anti-Anxiety Agents; Antimanic Agents; Behavior, Animal; Biomarkers; Brain; Drug Therapy, Combination; Gene Expression Regulation; Genes, fos; Hypnotics and Sedatives; Larva; Pentylenetetrazole; Plant Extracts; Proto-Oncogene Proteins c-fos; Swimming; Valerian; Valproic Acid; Zebrafish | 2016 |
Synthesis and Anticonvulsant Activity of N-(Substituted)-1-methyl-2,4-dioxo-1,2-dihydroquinazoline-3(4H)-carboxamides.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroshock; Methaqualone; Mice; Pentylenetetrazole; Picrotoxin; Quinazolines; Seizures; Structure-Activity Relationship; Valproic Acid | 2016 |
Seizures triggered by pentylenetetrazol in marmosets made chronically epileptic with pilocarpine show greater refractoriness to treatment.
Topics: Animals; Anticonvulsants; Brain; Callithrix; Carbamazepine; Chronic Disease; Disease Models, Animal; Electrocorticography; Epilepsy; Female; Immunohistochemistry; Male; Neuropeptide Y; Pentylenetetrazole; Phenobarbital; Pilocarpine; Proto-Oncogene Proteins c-fos; Seizures; Valproic Acid | 2016 |
Evidence in support of using a neurochemistry approach to identify therapy for both epilepsy and associated depression.
Topics: Animals; Anticonvulsants; Brain; Depression; Depressive Disorder; Disease Models, Animal; Dopamine; Epilepsy; Glutamic Acid; Hindlimb Suspension; Kindling, Neurologic; Male; Mice; Neurochemistry; Norepinephrine; Pentylenetetrazole; Seizures; Serotonin; Treatment Outcome; Valproic Acid | 2016 |
Octreotide ameliorates inflammation and apoptosis in acute and kindled murine PTZ paradigms.
Topics: Animals; Anti-Inflammatory Agents; Anticonvulsants; Apoptosis; Caspase 3; Cerebral Cortex; Cytoprotection; Disease Models, Animal; Dopamine; Inflammation; Inflammation Mediators; Interleukin-10; Kindling, Neurologic; Male; Mice; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase Type II; Octreotide; Pentylenetetrazole; Peroxidase; Reaction Time; Seizures; Time Factors; Tumor Necrosis Factor-alpha; Valproic Acid | 2017 |
Adjuvant neuronal nitric oxide synthase inhibition for combined treatment of epilepsy and comorbid depression.
Topics: Animals; Anticonvulsants; Chemotherapy, Adjuvant; Depression; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epilepsy; Male; Mice; Nitric Oxide Synthase Type I; Pentylenetetrazole; Seizures; Treatment Outcome; Valproic Acid | 2017 |
Trimetazidine potentiates the antiepileptic activity and ameliorates the metabolic changes associated with pentylenetetrazole kindling in rats treated with valproic acid.
Topics: Animals; Anticonvulsants; Aorta; Biomarkers; Blood Glucose; Drug Synergism; Epilepsy; Hippocampus; Insulin; Insulin Resistance; Kindling, Neurologic; Liver; Male; Oxidative Stress; Pentylenetetrazole; Rats; Rats, Wistar; Trimetazidine; Valproic Acid | 2017 |
Circadian variation in anticonvulsant activity of valproic acid in mice.
Topics: Animals; Anticonvulsants; Circadian Rhythm; Drug Administration Schedule; Male; Mice; Pentylenetetrazole; Seizures; Valproic Acid | 2017 |
Pharmacokinetic and pharmacodynamic interaction of hydroalcoholic extract of Ocimum sanctum with valproate.
Topics: Animals; Anticonvulsants; Antioxidants; Avoidance Learning; Cognition; Disease Models, Animal; Drug Therapy, Computer-Assisted; Epilepsy; Male; Neuroprotective Agents; Ocimum sanctum; Oxidative Stress; Pentylenetetrazole; Plant Extracts; Rats; Rats, Wistar; Seizures; Valproic Acid | 2017 |
Calcitonin potentiates the anticonvulsant and antinociceptive effects of valproic acid and pregabalin in pentylenetetrazole-kindled mice.
Topics: Analgesics; Animals; Anticonvulsants; Brain; Calcitonin; Drug Synergism; gamma-Aminobutyric Acid; Mice; Pentylenetetrazole; Pregabalin; Seizures; Valproic Acid | 2018 |
[Establish and use of an epilepsy model in larval zebrafish].
Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Epilepsy; Larva; Nerve Tissue Proteins; Pentylenetetrazole; Proto-Oncogene Proteins c-fos; Seizures; Swimming; Valproic Acid; Zebrafish; Zebrafish Proteins | 2016 |
Evaluation of ghrelin, nesfatin-1 and irisin levels of serum and brain after acute or chronic pentylenetetrazole administrations in rats using sodium valproate.
Topics: Animals; Anticonvulsants; Biomarkers; Brain; Calcium-Binding Proteins; Disease Models, Animal; DNA-Binding Proteins; Epilepsy; Fibronectins; Ghrelin; Male; Nerve Tissue Proteins; Nucleobindins; Pentylenetetrazole; Random Allocation; Rats, Wistar; Seizures; Valproic Acid | 2018 |
[COMPARISON OF CHRONIC ANTICONVULSANT ACTIVITY AND SAFETY OF IEM-2062, SODIUM VALPROATE AND ME-MANTINE IN THE PENTYLENETETRAZOL KINDLING MODEL IN RATS].
Topics: Administration, Oral; Animals; Anticonvulsants; Convulsants; Cyclohexanes; Cyclohexylamines; Drug Administration Schedule; Kindling, Neurologic; Locomotion; Male; Memantine; Pentylenetetrazole; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Seizures; Valproic Acid | 2017 |
Effect of valproic acid alone or combined with low dose gamma irradiation in modulating PTZ-induced convulsions in rats involving AKT/m-TOR pathway.
Topics: Animals; Anticonvulsants; Convulsants; Gamma Rays; Gene Expression Regulation; Male; Pentylenetetrazole; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Seizures; TOR Serine-Threonine Kinases; Valproic Acid | 2018 |
Effects of enalapril and losartan alone and in combination with sodium valproate on seizures, memory, and cardiac changes in rats.
Topics: Animals; Anticonvulsants; Drug Therapy, Combination; Enalapril; Heart Diseases; Kindling, Neurologic; Losartan; Male; Memory; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; Treatment Outcome; Valproic Acid | 2019 |
The effect of co-administration of pentylenetetrazole with pilocarpine: New modified PTZ models of kindling and seizure.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Drug Resistance; Epilepsy; Kindling, Neurologic; Male; Miotics; Pentylenetetrazole; Phenytoin; Pilocarpine; Rats; Rats, Wistar; Seizures; Valproic Acid | 2019 |
N-Benzyl-(2,5-dioxopyrrolidin-1-yl)propanamide (AS-1) with Hybrid Structure as a Candidate for a Broad-Spectrum Antiepileptic Drug.
Topics: Animals; Anticonvulsants; Behavior, Animal; Dose-Response Relationship, Drug; Epilepsy; Ethosuximide; Lacosamide; Levetiracetam; Male; Mice; Pentylenetetrazole; Pyrrolidines; Seizures; Valproic Acid; Zebrafish | 2020 |
Sodium Valproate Reduces Neuronal Apoptosis in Acute Pentylenetetrzole-Induced Seizures via Inhibiting ER Stress.
Topics: Animals; Anticonvulsants; Apoptosis; Cinnamates; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Heat-Shock Proteins; Hippocampus; Male; Mice, Inbred C57BL; Neuroprotective Agents; Pentylenetetrazole; Seizures; Thiourea; Transcription Factor CHOP; Valproic Acid | 2019 |
Intestinal inflammation increases convulsant activity and reduces antiepileptic drug efficacy in a mouse model of epilepsy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Colitis; Convulsants; Dextran Sulfate; Disease Models, Animal; Epilepsy; Male; Mesalamine; Mice; Pentylenetetrazole; Valproic Acid | 2019 |
Evaluation of sodium valproate loaded nanoparticles in acute and chronic pentylenetetrazole induced seizure models.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Maze Learning; Oxidative Stress; Pentylenetetrazole; Rats, Wistar; Seizures; Valproic Acid | 2019 |
Exploring the ameliorative role of α7 neuronal nicotinic acetylcholine receptor modulation in epilepsy and associated comorbidities in post-PTZ-kindled mice.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Anticonvulsants; Corticosterone; Depression; Dose-Response Relationship, Drug; Epilepsy; Kindling, Neurologic; Male; Memory Disorders; Mice; Pentylenetetrazole; Phenytoin; Valproic Acid | 2020 |
Long-term vigabatrin treatment modifies pentylenetetrazole-induced seizures in mice: focused on GABA brain concentration.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Brain; Clonazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Ethosuximide; gamma-Aminobutyric Acid; Mice; Pentylenetetrazole; Seizures; Time Factors; Valproic Acid; Vigabatrin | 2020 |
Effects of Diclofenac Versus Meloxicam in Pentylenetetrazol-Kindled Mice.
Topics: Animals; Anticonvulsants; Diclofenac; Epilepsy; Kindling, Neurologic; Male; Meloxicam; Mice; Pentylenetetrazole; Seizures; Valproic Acid | 2020 |
Autophagy associated with the efficacy of valproic acid in PTZ-induced epileptic rats.
Topics: Animals; Anticonvulsants; Autophagy; Convulsants; Drug Resistance; Epilepsy; Male; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Valproic Acid | 2020 |
Synthesis, anticonvulsant, and antinociceptive activity of new 3-(3-methyl-2,5-dioxo-3-phenylpyrrolidin-1-yl)propanamides and 3-phenyl-butanamides.
Topics: Amides; Analgesics; Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Male; Mice; Pain; Pentylenetetrazole; Seizures; Structure-Activity Relationship; Valproic Acid | 2021 |
Pharmacodynamic and pharmacokinetic interactions of hydroalcoholic leaf extract of Centella asiatica with valproate and phenytoin in experimental models of epilepsy in rats.
Topics: Adjuvants, Pharmaceutic; Animals; Anticonvulsants; Behavior, Animal; Centella; Cognitive Dysfunction; Cytochrome P-450 Enzyme Inhibitors; Disease Models, Animal; Electroshock; Epilepsy; Glutathione; Herb-Drug Interactions; Malondialdehyde; Medicine, Ayurvedic; Methanol; Oxidative Stress; Pentylenetetrazole; Phenytoin; Plant Extracts; Plant Leaves; Rats, Wistar; Seizures; Valproic Acid | 2021 |
Pergularia daemia hydro-ethanolic extract protects against pentylenetetrazole kindling-induced seizures, oxidative stress, and neuroinflammation in mice.
Topics: Animals; Anti-Inflammatory Agents; Anticonvulsants; Antioxidants; Apocynaceae; Cameroon; Cognitive Dysfunction; Dose-Response Relationship, Drug; Epilepsy, Temporal Lobe; Kindling, Neurologic; Male; Mice; Neuroinflammatory Diseases; Neuroprotective Agents; Oxidative Stress; Pentylenetetrazole; Plant Extracts; Valproic Acid | 2021 |
Response to sertraline and antiepileptic drugs in pentylenetetrazole kindling in rats.
Topics: Animals; Anticonvulsants; Avoidance Learning; Cognition Disorders; Convulsants; Glutathione; Kindling, Neurologic; Levetiracetam; Male; Maze Learning; Oxidative Stress; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; Selective Serotonin Reuptake Inhibitors; Sertraline; Valproic Acid | 2021 |
Treatment with the combination of clavulanic acid and valproic acid led to recovery of neuronal and behavioral deficits in an epilepsy rat model.
Topics: Animals; Clavulanic Acid; Epilepsy; Kindling, Neurologic; Male; Pentylenetetrazole; Rats; Rats, Wistar; Valproic Acid | 2021 |
Anticonvulsive Effects of Chondroitin Sulfate on Pilocarpine and Pentylenetetrazole Induced Epileptogenesis in Mice.
Topics: Animals; Anticonvulsants; Chondroitin Sulfates; Male; Mice; Molecular Docking Simulation; Neuroprotective Agents; Oxidative Stress; Pentylenetetrazole; Pilocarpine; Seizures; Status Epilepticus; Valproic Acid | 2021 |
Transcranial photobiomodulation add-on therapy to valproic acid for pentylenetetrazole-induced seizures in peripubertal rats.
Topics: Animals; Anticonvulsants; Humans; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Seizures; Valproic Acid | 2022 |
4-Phenylbutyric Acid Plus Valproic Acid Exhibits the Therapeutic and Neuroprotective Effects in Acute Seizures Induced by Pentylenetetrazole.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Male; Neuroprotective Agents; Pentylenetetrazole; Phenylbutyrates; Rats; Seizures; Valproic Acid | 2022 |
Investigation into Antiepileptic Effect of Ganoderic Acid A and Its Mechanism in Seizure Rats Induced by Pentylenetetrazole.
Topics: Animals; Anticonvulsants; bcl-2-Associated X Protein; Caspase 3; Epilepsy; Heptanoic Acids; Lanosterol; Pentylenetetrazole; Proto-Oncogene Proteins c-bcl-2; Rats; Receptors, Calcium-Sensing; Seizures; Valproic Acid | 2022 |
Design of self-assembling anti-epileptic drug for long-acting drug delivery
Topics: Animals; Drug Delivery Systems; Esters; Mice; Pentylenetetrazole; Polyethylene Glycols; Valproic Acid | 2022 |
Imatinib Attenuates Pentylenetetrazole Kindled and Pilocarpine Induced Recurrent Spontaneous Seizures in Mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Imatinib Mesylate; Mice; Pentylenetetrazole; Pilocarpine; Seizures; Status Epilepticus; Valproic Acid | 2023 |
Overexpression of Homer1b/c induces valproic acid resistance in epilepsy.
Topics: Animals; Anticonvulsants; Epilepsy; Mice; Pentylenetetrazole; Rats; Receptor, Metabotropic Glutamate 5; Seizures; Valproic Acid | 2023 |
The blockade of transient receptor potential ankyrin 1 (TRPA1) protects against PTZ-induced seizure.
Topics: Animals; Ankyrins; Anticonvulsants; Epilepsy; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; TRPA1 Cation Channel; Valproic Acid | 2023 |
Effect of valproate on sleep patterns disturbed by epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Pentylenetetrazole; Quality of Life; Rats; Rats, Wistar; Seizures; Sleep; Valproic Acid | 2023 |
Valproic Acid Attenuated PTZ-induced Oxidative Stress, Inflammation, and Apoptosis in the SH-SY5Y Cells via Modulating the TRPM2 Channel.
Topics: Apoptosis; Humans; Inflammation; Neuroblastoma; Oxidative Stress; Pentylenetetrazole; TRPM Cation Channels; Valproic Acid | 2022 |
The Effect of Adenosine Signaling on Memory Impairment Induced by Pentylenetetrazole in Zebrafish.
Topics: Adenosine; Animals; Dipyridamole; Epilepsy; Pentylenetetrazole; Quality of Life; Seizures; Valproic Acid; Zebrafish | 2023 |
Efficacy and mechanisms of Dingxian pill combined with valproic acid on pentylenetetrazol-induced chronic epilepsy in rats.
Topics: Animals; Anticonvulsants; Epilepsy; Pentylenetetrazole; Rats; Seizures; Valproic Acid | 2023 |
Pharmacometabolic Effects of Pteryxin and Valproate on Pentylenetetrazole-Induced Seizures in Zebrafish Reveal Vagus Nerve Stimulation.
Topics: Acetylcholine; Animals; Anticonvulsants; Choline; Humans; Pentylenetetrazole; Seizures; Serotonin; Tandem Mass Spectrometry; Vagus Nerve Stimulation; Valproic Acid; Zebrafish | 2023 |
Effect of digoxin, sodium valproate, and celecoxib on the cerebral cyclooxygenase pathway and neuron-specific enolase under the pentylenetetrazole-induced kindling in mice.
Topics: Animals; Anticonvulsants; Celecoxib; Digoxin; Epilepsy; Mice; Neuroinflammatory Diseases; Pentylenetetrazole; Phosphopyruvate Hydratase; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Valproic Acid | 2023 |